EP1753491A1 - Dose-dispensing device - Google Patents

Dose-dispensing device

Info

Publication number
EP1753491A1
EP1753491A1 EP20050737427 EP05737427A EP1753491A1 EP 1753491 A1 EP1753491 A1 EP 1753491A1 EP 20050737427 EP20050737427 EP 20050737427 EP 05737427 A EP05737427 A EP 05737427A EP 1753491 A1 EP1753491 A1 EP 1753491A1
Authority
EP
Grant status
Application
Patent type
Prior art keywords
characterized
device according
scale
dose
rotational movement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20050737427
Other languages
German (de)
French (fr)
Inventor
Edgar Hommann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TecPharma Licensing AG
Original Assignee
TecPharma Licensing AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/3155Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M2005/3125Details specific display means, e.g. to indicate dose setting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M2005/3125Details specific display means, e.g. to indicate dose setting
    • A61M2005/3126Specific display means related to dosing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/3152Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033Spring-loaded one-shot injectors with or without automatic needle insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/3146Priming, e.g. purging, reducing backlash or clearance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/31556Accuracy improving means
    • A61M5/31558Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/31563Mechanically operated dose setting member interacting with a displaceable stop member
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202Devices for protection of the needle before use, e.g. caps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3287Accessories for bringing the needle into the body; Automatic needle insertion
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16HGEARING
    • F16H1/00Toothed gearings for conveying rotary motion
    • F16H1/28Toothed gearings for conveying rotary motion with gears having orbital motion
    • F16H1/32Toothed gearings for conveying rotary motion with gears having orbital motion in which the central axis of the gearing lies inside the periphery of an orbital gear

Abstract

A dose-dispensing device (200) for an administration appliance, in particular an injection appliance for administering doses of a substance, comprises: (a) a dose-adjusting device (10, 24, 26) for adjusting a dose of substance to be administered by means of a first rotary motion; and (b) a graduated scale (60) which can be rotated with a second rotary motion for reading the adjusted dose. The device is characterised in that (c) a gearing (10c, 24, 42, 210a, 210b, 52) couples the first rotary motion to the second rotary motion in such a way that the second rotary motion is slower than the first.

Description

metering

The present invention relates to a metering device with a scale for administering apparatus, particularly an injection, infusion, or inhalation device.

In the aforementioned devices, it is possible to set different dose sizes. It is desirable here that the set dose from the device can be read. For this, a scale can be attached to the device.

Object of the present invention is to provide a dosing device with scale, which allows a compact construction of the aforementioned devices.

The aforementioned object is solved by claims 1 and 11. FIG. Advantageous embodiments emerge from the dependent claims.

According to the present invention, a metering device is preferably provided for an injection device to administer a substance dosed. The substance is, in particular, a medicinal substance or a drug that is located in particular in a fluid, in particular liquid state. In the medical substance may for example be insulin.

The metering device preferably comprises a dose setting means for setting the dose to be administered the substance. The dose is preferably adjusted by a first rotary motion, which then sets a delivery stroke, which is effected by a drive device. The drive device acts for dispensing to a power take-off device. This output device includes a lift sleeve, which acts on the piston of an ampoule, in order to deliver the predetermined dose. The dose setting means comprising, for example, an axle rod and the lift sleeve, wherein the first rotational movement causes rotation of the rod axis. This rotary motion is then converted, for example, via an external thread of the axle rod which engages into an internal thread of the lift sleeve. The lift sleeve is preferably mounted so that they can not rotate and therefore performs a translational movement upon rotation of the female thread in the longitudinal direction. the dose setting then takes place by moving the lift sleeve in the longitudinal direction because the lift sleeve acts on the piston and covers a predetermined delivery stroke in the longitudinal direction or the axial direction, irrespective from which position starts from the lift sleeve. In this manner, a different amount depending on the position of the lift sleeve in the axial direction, which has been determined by the metering device, distributed to fluid. Was approximated to the piston before the delivery stroke of predetermined length is performed by the metering device, the lift sleeve, the more liquid will be distributed, as in the nichtangenäherten state.

The metering device according to the invention preferably further comprises a rotatable scale for reading the set dose. This scale is rotatable by a second rotation movement. The second rotation movement is preferably coupled to the first rotational movement, but preferably differs in its speed from the first. In particular, the second rotational movement is slower than the first rotational movement. This means that if, for example, by hand, a first rotary movement about a first angle is caused due to the coupling this has a second rotary motion about a second angle to the sequence that is less than the first angle. Preferably, the reduction is such that the speed of the scale by more than a factor of 2, 4, 6, 8, 10 or 20 is less than the speed of the first rotary motion, with which the dose setting is made. In this way, the scale can be made very compact. In particular, it is possible to cover with a single scale revolution the entire range of possible dosing. This allows a particularly compact design of the dosing device, since a translational and space-consuming movement of the scale to indicate the larger dosages, is not required. Preferably, the metering device according to the invention is designed so that the axes of rotation of the dose setting and the scale parallel to each other or are identical, in order to increase the compactness of the scale. In particular, the axes of rotation are designed so that they are identical or a rotation axis to rotate about the other.

The inventors have found that a particularly compact design of the metering device is achieved by a differential gear, in particular a pulley transmission curve, in particular cycloidal cam gear or so-called harmonic drive. In such transmissions, the rotations run into each other, allowing for increased compactness. Nevertheless, a high reduction ratio can be achieved, so as to make a translational movement of the scale necessary. Preferably, an annular cycle disk is provided, whose rotational movement represents the second rotational movement. The circular inner periphery of the cycle disk is provided with an eccentric contact that rotates with the first rotary motion and is preferably coupled to both an adjustment ring and with the rotating movement of the metering rod so that rotation of the adjustment ring with the first rotational movement, rotation of the metering rod also effected with the first rotational movement. Due to the contact between the eccentric and the inner circumference of the washer cycle, the cycle disc is rolled with its inscribed meshing external teeth on a preferably likewise cycloidal internal teeth of a ring surrounding the cycle disc. The number of cycloidal teeth ZI determines Zykloi- denscheibe and the number Z2 of the cycloid inner teeth of the outer ring, the reduction ratio i according to the following formula: i = (Z2 - Zl) / Z2.

Preferably, the scale of the metering device is designed so that it does not undergo translational movement along the longitudinal axis, but at a transit through the second rotational movement at a predetermined longitudinal position or the axial position of the rotation axis of the scale or remains in a predetermined longitudinal portion of the metering device and remains without longitudinal movement. The adjusting and the scale are preferably concentrically arranged to obtain an even further compact structure of the dosing device. This also allows the placement of a Prime knob at the rear end of the dosing device, so the outlet end of an injection device opposite end. This Prime button can then be preferably positioned so that it acts on the stroke adjusting rod of the metering mechanism. More preferably, the Prime button is arranged such that it is protected by the housing and only exposed his actuating surface. This can be prevented, for example, dropping the unit accidental priming. Preferably, the adjusting ring surrounds the scale and is directly connected or integral with the first axis of rotation of the first rotational movement. The connection preferably extends radially beyond the scale from the outside inwards towards the axis of rotation. "Background" is used in this application in the sense that the front end (distal end) of the injection device is used for ejecting a fluid. This front end opposite in the longitudinal direction of the injection device the rear end (proximal ale end), at which preferably the metering device according to the invention is attachable or attached.

Preferably, the adjustment is transparent or at least transparent at the locations at which it would obscure the scale for a viewer. The adjustment is so transparent in particular at least in the same longitudinal section of the dosing, in which the scale is. Specifically, in the transparent part of the adjustment ring a magnifying lens may be provided in order to improve the readability of the scale, which can be formed very closely dashed or labeled, due to the reduction.

The present invention is also directed to a delivery device for administering a fluid product, preferably for medical, including veterinary, therapeutic, diagnostic, pharmaceutical and / or cosmetic applications. Injection devices, especially injection pens and inhalers are preferred examples of administration devices. in particular, the delivery devices of the invention comprise the dosing device according to the invention to administer the substance dispensed.

The axes of the first and / or second rotary movement preferably match with the longitudinal axis of the administration device or preferably extend at least parallel to the longitudinal axis of the delivery device in order to achieve a compact structure.

Fig. 2 shows a possible embodiment of a front end of a delivery device.

Hereinafter, an embodiment of the invention will be described.

Figure la shows a cross section through a metering device and Figure 1b shows a cross section through a cycloid gear 40, which is used in the embodiment of figure la.

The metering mechanism 10 comprises an adjusting ring 10a. From this adjustment ring 10a is a bridge 10b is facing. This bridge 10b extends radially inwards, in particular perpendicular to one part of the ring, in the direction of the longitudinal axis 22 and the device 20. Before the bridge 10b, the longitudinal axis 22 reaches, it meets 10c on the eccentric sleeve. This sleeve 10c rotates eccentrically around the axis 22 of the injection device and its identical axis 22 of the metering device 100, which occupies the right portion of the displayed injection device 200 in Figure la.

Figure lb shows a cross-section through the cycloidal gear 40 that comes in the dosing device used. The eccentric sleeve 10c surrounds the longitudinal axis 22 of the axle rod 24, which is rotatable about the longitudinal axis of the 22nd

When rotating the eccentric sleeve 10c, the axis rod positively connected to the eccentric sleeve 24 rotates with. The right end in Figure la, the rear end which lies opposite to the end at which the injection device ejects a product or fluid. The ejection end (not shown in Figure la) is the front end.

The shaft rod 24 moves toward the front end in a smaller diameter portion 24a. This smaller portion 24a preferably has an external thread which is connected to the internal thread of a lift sleeve 26 in engagement. The lift sleeve is preferably mounted in a rotationally secure, so does not rotate with the axle rod 24th Upon rotation of the shaft rod 24 so the lift sleeve 26 moves forward or backward. In this way, the stroke is set which a piston 110 during actuation or triggering of the injection unit (see Fig. 2) acts which pushes out a fluid from a reservoir 120 at the front end of the injection device.

The needle assembly 150 shown in Fig. 2 can be attached to the front end 132 of the vial 130 after the needle assembly has been turned 150. The injection device is then ready for operation, then A detent (not shown) of a feed sleeve are dissolved in the housing 210 32nd This then leads to a Einstechfeder 112, the feed sleeve 132 drives forward. The feed sleeve 32 acts on the ampoule 130 and pushes it along with the needle from the front end 210a of the housing 210 out, to perform the piercing operation.

The feed sleeve 32 takes with it over the edge 32a, the lift sleeve 26th Is a designated limit stops 132 reached for the forward movement of the ampoule, so a discharge A detent sleeve 34 is released. This discharge sleeve 34 is driven by the spring 36 in the forward direction. The ejection sleeve 36 is connected at its front end with a detent element 37th The locking element 37 is formed so that it is the lift sleeve 26 takes along in forward direction on forward movement of the ejection sleeve 36th The ejection sleeve 36 engages after covering a predetermined path in a provided in the feed sleeve 32 Einrastelle (not shown), which is located at a position corresponding to the predetermined path. After the sticking operation the locking element 37 thus travels a predefined path in the longitudinal direction, which causes pouring. The latching element 37 is designed such that it allows ratchet-like manner relative movement of the lift sleeve 26 relative to the latching element 37 when the locking element is stationary 37 and the lift sleeve is moved in the forward direction through the metering device, so if the stroke adjusting sleeve 26 moves relative to the latching element 37 to the front becomes. However, the latching element 37 wants to move relative to the lift sleeve 36 forward due to the spring action of the spring, it picks up the lift sleeve 26 due to the configuration of the screening.

In this manner it is achieved that the lift sleeve 26 always executes a lifting movement of equal length to the front, regardless of what distance has relatively from the piston 110th Thus, the piston 110 is moved forward at different distances depending on the longitudinal position of the stroke adjusting rod so that a different Ausschüttdosis is effected.

As set forth above, thus takes place by turning the adjustment ring 10a is a stroke adjustment means of the lift sleeve 26th

If now the eccentric sleeve is rotated about the longitudinal axis 22 10c, it not only assumes the axis of rod 24 1: 1, but presses with the part of the outer periphery which is remote from the longitudinal axis furthest against the inner periphery of a cycloid 42. This inner peripheral is preferably circular. The cycloid rolls off with its cycloidal outer periphery to an inner periphery of a ring 44, while the eccentric sleeve 10c is rotated and thereby moves with the eccentric point of the outer circumference along the inner circumference of the cycloid 42nd In this manner Zykloidenabschnitte be pressed in the cycloid 42 in correspondingly shaped recesses of the cycloid ring 44 gradually the above. In figure lb the straight Zykloidenabschnitte 42a and 42b of the cycloid 42 are completely fitted into a corresponding recess of the ring 44th the eccentric sleeve 10c moves in figure lb in the counterclockwise direction, it is rolled into the next Zykloidenabschnitt 42c in a corresponding bulge. This rolling movement of the cycloid causes rotation of the cycloid, but is significantly slower than the rotation of the eccentric sleeve. The speed reduction ratio i is calculated as i = (Z2-Zl) / Z2, where Z2 is the number of N type zykloide- bulges in the ring 44 and ZI is the number of matching Zykloidenabschnitte the cycloid 42nd

The cycloid 42 is used in the inventive dosing device, as shown in Figure la. She staggers around the longitudinal axis 22 with the above-described ratio. In the figure la, the cycloid 42 is located at the upper end in contact with the housing section 210a of the housing 210 of the metering device. This housing 210 is preferably also used as a housing for at least a portion of the injection device. At the opposite, lower end of Figure la the cycloid 42 is spaced from the housing portion 210b. Thus, the situation corresponds to that shown in Figure lb, wherein the cycloid is 42 and in its upper position is spaced from the ring 44 below.

The outer perimeter of the cycloid 42 in Figure la therefore also preferably includes the cycloidal curve sections at the outer periphery. The Iαnenumfang of the housing 210 in the longitudinal section area of ​​the cycloid 42, so the range in which the cycloid is staggering on the inner circumference of the housing 210 rolls (especially at 210a and 210b), the matching cycloid depressions on, so as already in connection with Figure lb discussed ring 44 is formed.

In the cycloid 42 are at least two recesses (not shown, in which driving pins 52 are located) that are integral with the scale 60th The scale 60 preferably rotates about the longitudinal axis 22 without an eccentric motion to be performed. The traversed during the rotational movement path is preferably defined by the inner wall of the housing 210 corresponding to the ring 44. The scale 60 is preferably formed as a cylinder jacket, from which radially inwardly, a ridge 60a extends, which is firmly connected with the driving pins 52nd In order to view the scale 65 a recess or a window is preferably in the housing, adjacent to the portion 210a, is provided, which can be read by machine or the scale. The driving pins 52 are fitted into the aforementioned recess in the cycloid with a game, so that they are carried along during the rotation of the cycloid, but the eccentric rotational movement of the cycloid about the longitudinal axis 22 does not have to follow. Characterized a non-eccentric movement of the scale 60 is effected around the longitudinal axis 22, which is slowed down in accordance with the reduction ratio i as compared to the rotational movement of the axle rod 24th

Overall, a metering device is achieved which allows Dosierverstellung in a broad scope, while the scale can be made more compact since no longitudinal movement of the scale to display a second dose range is necessary.

A Primingknopf 70 is preferably mounted at the rear end of the injection device and is designed so that it can be pressed in the direction of the longitudinal axis toward the front end to perform a priming stroke, which serves as the venting of the injection device. a sleeve-shaped recess lOd for this purpose are preferably formed in the dose setting means in which a corresponding running symmetrically to the longitudinal axis of the sleeve is guided 70d Primingknopfes 70th This sleeve 70d preferably surrounds the axis of rod 24, wherein the Primingknopf 70 24 terminates the rod axis to the rear, so as to push with a movement of Primingknopfes 70 forwards the axis of rod 24 forward in order to effect the priming stroke. Further, the Primingknopf is preferably fitted in the adjusting ring or the housing so that it does not protrude to the rear, but is still operable, for example by at least an exposed portion of its actuating surface.

Claims

claims
1. The metering device (200) for an administration device, in particular an injection device for the metered administration of a substance a) having a Dosiseinstelleiririchtung (10, 24, 26,) for setting a dose to be administered the substance by a first rotational movement; b) having a rotatable by a second rotation movement scale (60) for reading the set dose; characterized in that c) a transmission (10c, 24, 42, 210a, 210b, 52) the first rotational movement so coupled with the second rotary motion, that the second rotational movement is slower than the first.
2. A metering device according to claim 1, characterized in that the gear mechanism (10c, 24, 42, 210a, 210b, 52) is designed so that the axes of rotation (22) of the Eisten and second rotary movement are parallel or identical.
3. A dosing device according to claim 1 or 2, characterized in that the transmission comprises a differential gear.
4. A dosing device according to claim 3, characterized that the differential gear has an eccentric (10c) that rotates with the first rotary motion and is designed as a drive of the differential gear.
5. A dosing device according to claim 4, characterized in that the differential gear is a cycloidal cam gear (40).
6. A dosing device according to claim 4 or 5, characterized in that the output of the transmission is a cycloidal cam (42) whose rotary movement is coupled with the second rotational movement.
7. A dosing device according to any one of claims 1 to 6, characterized in that the scale (60) remains at any rotation at a predetermined longitudinal position of the rotary axis of second rotation.
8. A dosing device according to any one of claims 1 to 7, characterized in that the dose setting means (10) for causing the first rotational movement comprises a rotatable setting ring (10a) connected to a rotation mechanism (10c, 24, 24a, 26) for adjusting the dose is coupled.
9. A dosing device according to claim 8, characterized in that the adjusting ring (10a) and the scale (60) is annular, the axis (22) or axes of the first and second rotary motion surrounds.
10. A metering device according to claim 8 or 9, characterized in that the adjusting ring (10) at least partly (10a) is transparent and the scale (60) and the transparent part (10a) of the adjustment ring (65) are arranged so that the scale can be observed through the transparent portion.
11. The administering apparatus, in particular injection device for the metered administration of a substance with the metering device (200) according to any one of claims 1 to 10 degrees.
12. The administering apparatus, in particular injection apparatus of claim 11, characterized in that the axis (22) of the first and / or second rotational movement is parallel or identical to the longitudinal extension direction of the injection device.
EP20050737427 2004-05-25 2005-05-18 Dose-dispensing device Withdrawn EP1753491A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE102004025546 2004-05-25
PCT/CH2005/000276 WO2005115515A1 (en) 2004-05-25 2005-05-18 Dose-dispensing device

Publications (1)

Publication Number Publication Date
EP1753491A1 true true EP1753491A1 (en) 2007-02-21

Family

ID=34966591

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20050737427 Withdrawn EP1753491A1 (en) 2004-05-25 2005-05-18 Dose-dispensing device

Country Status (4)

Country Link
US (1) US20070225657A1 (en)
EP (1) EP1753491A1 (en)
JP (1) JP2007537800A (en)
WO (1) WO2005115515A1 (en)

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GB0918145D0 (en) 2009-10-16 2009-12-02 Owen Mumford Ltd Injector apparatus
EP2488234A1 (en) 2009-10-16 2012-08-22 Sanofi-Aventis Deutschland GmbH Drug delivery device

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