EP1740459A1 - Installation for filling packaging units with medicaments for patients according to the prescribed weekly requirements - Google Patents

Installation for filling packaging units with medicaments for patients according to the prescribed weekly requirements

Info

Publication number
EP1740459A1
EP1740459A1 EP05706833A EP05706833A EP1740459A1 EP 1740459 A1 EP1740459 A1 EP 1740459A1 EP 05706833 A EP05706833 A EP 05706833A EP 05706833 A EP05706833 A EP 05706833A EP 1740459 A1 EP1740459 A1 EP 1740459A1
Authority
EP
European Patent Office
Prior art keywords
characterized
transport
provided
strip
blister
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP05706833A
Other languages
German (de)
French (fr)
Other versions
EP1740459B1 (en
Inventor
Hans Klingel
Edwin Kohl
Original Assignee
Edwin Kohl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE200410020510 priority Critical patent/DE102004020510B4/en
Application filed by Edwin Kohl filed Critical Edwin Kohl
Priority to PCT/EP2005/000002 priority patent/WO2005102841A1/en
Publication of EP1740459A1 publication Critical patent/EP1740459A1/en
Application granted granted Critical
Publication of EP1740459B1 publication Critical patent/EP1740459B1/en
Application status is Expired - Fee Related legal-status Critical
Anticipated expiration legal-status Critical

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B5/00Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
    • B65B5/10Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles
    • B65B5/101Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity
    • B65B5/103Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity for packaging pills or tablets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B57/00Automatic control, checking, warning, or safety devices
    • B65B57/02Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of binding or wrapping material, containers, or packages
    • B65B57/06Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of binding or wrapping material, containers, or packages and operating to control, or to stop, the feed of articles or material to be packaged
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035Blister-type containers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers

Abstract

The invention relates to an installation for filling weekly blister packs, i.e packaging units (11), with doses of different medicaments corresponding to the weekly requirements of several patients and to be taken by the respective patient in a certain order according to the day of the week and the time of day, according to a doctor's prescription. Said installation is provided with output stations (19) associated with the medicaments, for automatically filling all or selected compartments (12) line-by-line. A longitudinal transport device (14) is used to sequentially transport the weekly blister packs to the output stations (16) that are individually associated with the different medicaments. The medicament doses are supplied to the output stations by means of transversal transport devices (17) individually associated with the medicaments. The longitudinal transport device and the transversal transport devices are co-ordinated in terms of transport course and transport capacity, in such a way that for each transport course of the weekly blister pack (11), in the direction of the gaps of the receiving compartment arrangement, and for each transport course of the transversal transport devices, in the linear direction of the receiving compartment arrangement, the receiving compartments (12) can be filled sequentially line-by-line, during synchronised stationary phases of the blister pack and medicament transport cycles. In order to control the output stations (16) in such a way as to fill the weekly blister pack with the prescribed medicament, an electronic control unit (41) processes information about patients, said information being continuously supplied to said unit in such a way that it is synchronised with the blister pack advancing movements.

Description

Plant for the assembly of packing units with the proper prescription week needs of patients corresponding medicaments

description

The invention relates to a system for the automatic loading of packaging units of medication with the individual weekly requirements of many patients appropriate administration units - capsules, tablets, pills - various medications by date in a - week - and time of day - morning, noon, evening, night - parent sequence corresponding to a patient-related medical prescription of each patient should be taken, and the other, mentioned in the preamble of claim 1, generically determining characteristics.

Pieces of the relevant prior art type have been vorbenutzt evident by the company Temmler GmbH in the Federal Republic of Germany in the form of medicine cassettes and therefore generally known.

Such packaging units are to be a help for the one hand, do not forget to take important drugs and, on the other hand to have a reliable overview of which drugs are already taken, for patients who have to take several different drugs regularly over-medication that are harmful could be avoided.

The "usual" placement of such cassettes "by hand" is very time consuming and practically only by highly trained professionals sufficiently reliably feasible, which is associated with correspondingly high labor costs.

In order to reduce such costs, a compact construction, and suitable for an application in the hospital sector plant is known [(1V / MEDI CO., LTD. 390-1, Shin Won Dong, Seo Cho Gu, Seoul, Korea)], the weekly requirements of a patients appropriate medication can be filled by machine into a packaging unit that manifest also supports compliance with the time sequence of the medication. On an input of the patient data would be, and the computer control is performed, the prescription data relating to the separation of the drug from a magazine containing up to 400 different drugs in separate cassettes, as well as the orderly in order of taking packing of the rejected drugs in ckungseinheiten tubular packaging, where the drugs can be taken if necessary, for further sorting. The patient-specific selection of the drugs and their packaging is serial, so that different patients assigned to drug sentences are obtained sequentially, ie, only begins with the selection of drugs for a patient after the selection of drugs for a previously considered patient has been completed.

The known plant is encumbered with the disadvantage that the loading of a plurality of packaging units with a relatively large time required is linked, since it can be started only with the filling of a packaging unit after a previously filled completely to be filled needs pack. For - as it were industrial - Use in the area of ​​pharmaceutical wholesaling in which it would be necessary to create ckungseinheiten a need in the area of ​​some 50,000 number of individual packaging daily, the known plant would not be suitable. Such amount needed would not make sense can be covered with the required reliability. The object of the invention is therefore to provide a plant of the aforementioned type which allows to achieve a drastic increase in the number of the dispensable individually different consumption pack units, with a typical order of magnitude for a 24-hour operation of the system a number of from 100,000 is to be considered, of course, subject to the constraint, the highest possible safety regulation compliance.

This object is achieved in accordance with the principles of the invention, by the characterizing features of claim 1 and advantageous embodiments and developments of the invention by the features of the further claims.

Thereafter, the medications individually associated output stations are provided in the inventive mounting system to which a time of day or day of the week-based assembly "row-wise" juxtaposed receiving compartments of the packaging unit is operable; Next a "longitudinal" -Transporteinrichtung is provided by means of which the packaging units sequentially to the different drugs individually assigned in a predetermined transport direction of dispensing stations can be transported, which are hereinafter provided in one of the number of drugs corresponding multiplicity and usable for equipping various cartridges;

the supply of the drug delivery units to the output station by means of the drugs individually associated transverse conveyors which are driven in parallel to output of drugs that are output for fitting a plurality of different packaging units; For this purpose, the longitudinal conveyor and the transverse conveyor means with respect to transport stroke and conveying capacity are matched to the effect each other such that per conveying stroke of the packaging units and per conveying stroke of the transverse conveying a respective row-wise loading of the receiving compartments can be achieved, which expediently in each case in synchronized stoppage phases of the longitudinal - takes place transport and medication delivery cycles; in the case of certain simple, regular filling patterns is possible for both the "longitudinal" transport of the packaging as well as, alternatively or additionally for the Querförde- tion of the drug, a continuous feed; means a provided for controlling the output stations electronic control unit, which generates the required control signals from processing information signals that contain the information about the patient and the respectively associated therewith contents of the packaging units and the control unit movements strictly correlated in with the cassette feed and are supplied to the patient clearly associated sequence continuously, is a widest possible reliability of the correct placement of the packaging units with medicaments achieved and a high temporal placement rate reached so that can be taken out of the system completely assembled packaging about every second, each an individual doctor's prescription correspond.

is are If, ​​as provided according to claim 2, to the control signals processed beitbare data in machine-readable form in spatially fixed relationship to the respective packaging units are provided, ie WEI with these are tertransportierbar and thereby achieve reading stations that are associated with the delivery stations, so the loading sequence can be controlled easily in the manner of a sequencer, which requires only a relatively low data processing effort and thus works quickly and reliably.

Here, an arrangement of an output station assigned reading station is convenient to the already allows for reading the data before the cassette to be assembled has reached the respective output station. The packaging units or the receiving compartments bounding portions thereof are expediently also provided with imprintable fields, the means of the delivery stations individually associated and of protocol in this integrated printing devices data are aufdruckbar by which the placement of the respective packaging unit can be respectively understood that for reasons may be the fail-safe and the possible need error analysis is very important.

Tablets, capsules, dragees or the like - - In a preferred construction, the mounting system of the invention, the drugs are equidistance tant disposed on Streifenblistem, which are wound onto a stock roll and there are transport drives between the roller and the output stations arranged which, in the transporting direction of the blister seen aufein- other subsequently disposed ejection units have means of which the medication from the blister pockets are ejected and can be output in the receiving compartments of the respective packaging units.

This type of drug-storing of the system and the realization of the drug-output to the packaging is particularly suitable for a modular construction of the overall system, such that an expansion of the system to a wider variety of medications readily possible and by inserting a new drug places can take place assigned unit. A "modular" Division of the system into groups of dispensing stations and those associated supply reels, for example, in groups of ten delivery stations or a higher-level grouping, in the example five such groups of ten are combined into a higher-level modular unit is readily possible to the extent to control purposes such. B. from the standpoint of achieving more balanced as possible assembly times for all medicine cassettes, seems advantageous. Control technology, it is particularly advantageous if the ejection units of a delivery station are arranged equidistant to each other, preferably so that the distance Lp of adjacent ejector units is a multiple whole number of the distance Ip of adjacent blister strip the Blisterhö- fe. In this design, the output stations for a can of transporting Streifenblisters. For example, be provided by means of a cross Malteser- feasible, simple stepper-transport, in a simple manner enables function in connection with a pedometer a reliable control of advance. It is understood that, in combination, a continuous blister strip feed can be provided with a suitably chosen path-measuring system.

suitable as ejection units are, in particular pneumatic Learzylin- of the return springs fitted with a single-acting cylinder can be formed or, depending on the power requirement in the alternative directions of motion, may be formed as double-acting cylinders.

By the features of claims 10 to 12 realizable features of the blister strip are given alternatively or in combination, which ensure reli- able transportation and also permit in a simple manner an automatic "threading" sequentially to-use blister strip.

By the features of claims 13 and 14, configurations of the advantages rats-blister strip are given which ensure gentle output of the medication from the blister pockets by ejection means of the ejection elements, as exerted on the medication by means of the discharge elements of the respective output station "ejection "forces can be kept low. The to the features of claims 11 and 12 Executed applies mutatis mutandis to the design of the delivery stations according to the features of claims 15 to 17, the advantage can be seen in a particularly gentle and protected against wear and against pollution treatment of the dispense medication. By means of a device provided in accordance with claim 18 to a common opening actuation of release members may be achieved both a constructive simplification of output stations as well as a time-saving implementation of the drug delivery in the receiving compartments of the packaging units.

In combination with actuators, as indicated by the features of claims 19 and 20 for measuring displacement or feed detection of the blister strip can be used a simple incremental encoder according to claim 21, whose signals, in combination with position sensors for edge markings of the blister strip, as according to the features of claims 22 and 23 specified, can be used to sufficiently precise position determinations for the motion control of the blister strip, for which purpose appropriate border markers 24 provided marking means the system itself can be obtained by means of claim. See also section stations can be used according to claim 25th According to claim 26 provided for the functional testing, security serving sensor devices can be realized in an advantageously simple arrangement and design according to claims 27 to 29, 24 to be.

Thanks to the modular construction of the assembly plant according to the invention, such that the modules each have a dispensing station, a Querför- dereinrichtung, drives a supply roll for a respective blister strip and Zustellan- and include auxiliary drives and the required position measuring and monitoring sensors, it is by the addition of such modules for statistically frequently used drugs readily possible with relatively little effort "uniformly" and appropriately working loading stückungsanlagen according to the features of claim 30, preferably in the design according to claim 31 to realize. Alternatively or additionally, a demand expansion of the capacity of a mounting system of the invention also having the features of claim 32 having two or more transport systems for packaging can be displayed.

By constructing the assembly plant according to the features of claim 33, a continuous mounting operation can also be realized with a uniformly continuous flow of medication when the time required at the various dispensing stations is different.

A particularly efficient production of week needs blisters as packaging can be achieved in a preferred construction, the mounting system of the invention according to the features of claim 34:

Further details of the invention will become apparent from the following description of embodiments with reference to the drawing. Show it:

Fig. 1 shows a first embodiment of an installation according to the invention for the assembly of packing units of medication in a schematically simplified plan view,

FIG. 2a shows details of a dispensing station of the system of Figure 1 in section along line II / II of Figure 1, also schematically simplified..;

FIG. 2b shows various phases of the drug outlet at the Ausgabis 2e bestation of Figure 1 for explaining the function of the system.

. FIG. 3a shows details of another embodiment of a inventions to the invention in a system of Figure 1 corresponding representation; Figure 3b is a schematically simplified view of a usable in the plant according to FIG 1 or 3a incremental operating position encoder..;

FIG. 4a is a blister strip for changing-supply rolls suitable switching means in a schematically simplified side view;

FIG. 4b is a mark for generating signals in a system according to Figure 1 or 3 a suitable Lichtschrankenanordung.

FIG. 5a is a driving means for the transport drive of a strip-fenblisters according to Fig. 4a;

Fig. 5b and 5c each guide means of the switching device overall measure FIG. 4a;

6A to 6D are details of the blister strip configuration for explaining its function.

Fig. 7a shows a further design of a dispensing station of a plant according to Figure 1 in a view corresponding to FIG 2a..;

Fig. 7b details of a drive of the dispensing station of FIG. 7a and

Fig. 7c is a simplified sectional illustration of a monitoring light barrier for the dispensing station of FIG. 7a.

The generally designated in Fig. 1 with 10 mounting system is designed for the filling of packaging units 11 with medications that are to be taken from a patient in the course of a week, with this packaging an aid should be to the effect for the patient, that it, corresponding to takes up a medical prescription, a plurality of different drugs in prescription equitable dosage and time sequence, this can not forget anything and also control easily what has been taken from him and has yet to be taken.

The packaging units 11 are formed in the type of blister packages in which a plurality of the basic shape according to rechteckig- trough-shaped receiving compartments 12 which zusammenge- in a regular rectangular matrix configuration to form a single transport plate 13 are touched. According to a design of a so-called weekly blister, with the weekly drug requirements of a patient is provided 13 a total of twenty-eight receiving compartments comprises the transport board 12 of the same basic shape which at the chosen way of illustration specific embodiment in the number of days of the week corresponding number of columns and four , the various administration times - morning, noon, evening and night are arranged -zugeordneten lines.

In the direction of - four - in the direction of rows and - seven - seen columns of the respective transport board 13, the receptacles 12 are arranged in each case equidistantly.

By means of a generally designated 14, only schematically indicated longitudinal transport means, said means can be realized in the manner of a "linear" conveyor belt, which has its own drive, or may be realized by means of a plurality of drives, the "direct" in engage the transport boards 13 with the drugs to be loaded transport boards 13 are sequentially arranged along this transport device 14, a total of transportable with 16 designated output stations. a drug is respectively output from these output stations, wherein the drug dispensing takes place at the respective delivery station 16 "row-wise" in such a way that, during a standstill phase of the longitudinal transport means 14 each time of administration - morning, noon, evening or night - associated administration units in the respective administration days Monday and / or Tuesday to Sunday, etc. associated with receiving compartments are entered 12th

The supply of medicines to the discharge stations 16 carried in turn by means of the drugs individually associated, respectively allocates a total reasonable with 17 designated cross-conveyors which, equidistantly in the transport direction of the transport boards 13 along the transport means 14, wherein the distance between adjacent transverse conveyors 17 suitably equal to the measured in the transport direction width b of the transport board 13 is selected and the circuit boards 13 are designed for their part so that, in a transport configuration of the plates 13, where they compete with their transverse to the transport direction edges 18 / r and 18 / v abut directly against one another, the spacing of the respective adjacent receiving compartment rows, the one night-intake and the other of the morning administration is associated is the same as the distance between two mutually adjacent within a circuit board 13 plural rows and the feed increment corresp layer with which a z. B. taktgesteuer- ter feed the transport boards 13 in the transport direction of the transport device 14 takes place. In a typical design of the transport boards 13 they are formed of their respective longitudinal center plane 19 symmetrically with respect extends between the two inner of the lunch and the evening taking associated rows of storage compartments 12 and vertically on the area marked by the opening edges of the trays 12 level stands.

The the medicaments individually associated transverse conveyor are realized with the aid of Streifenblistern 21 disgusted aufgewi- on supply rolls 22 and are removable therefrom. The supply rolls 22 are of - added flat cassettes which can also form the stock, in which the rollers when the - - the sake of simplicity, not shown, are rotatably supported cartridges are installed in the system 10 - replaceable.

The blister strip 21, is now also made to Figure 2a to 2e with respect to the explanation thereof, consist of strip-shaped plastic foil 26 having formed on one side hemispherical or trough-shaped courts 23, which are provided for receiving in each case a tablet or a drug capsule. The borders of the respective drugs containing in turn are covered with a sheet-shaped cover strip 24, which is integrally connected to the courtyards 23 forming plastic strip 26. The cover strip 24 may itself be constructed as a plastic strip, however, is often formed as a thin strip of aluminum or metallized plastic strip, which is provided in the region of the yard-openings acting as predetermined breaking points line-shaped embossed or incorporated functional analog perforations opening or facilitate mechanical removal of the drugs from the farms 23rd

The borders 23 are immediacy in the illustrated design example for explaining the Streifenblistem 21 "tight" -nebeneinander arranged to achieve maximum supply capacity per supply roll 22nd seen in the transporting direction of the blister strip 21, which cross the seven receiving compartments arranged side by side respectively in a time-of-row receptacles 12, and these are equally tight, ie arranged mutually directly adjacent such that remaining between two neighboring receiving compartments 12, in the direction of transport the weekly blister extending dividers against the measured transversely to the transport direction of the weekly blister clear width of the Aufnahmefach- are narrow openings. In a typical design of Wochenblister- transport boards 13 transversely chenblister to the transport direction of the WO 11 measured periodicity length Lp corresponding to the row arrangement of the receiving compartments 12 of the transport board 13 is three times the value of Ip of the corresponding measured periodicity of the arrangement of the courtyards 23 of the blister strip 21 or other integer multiples of this periodicity Ip, preferably an odd multiple thereof.

With this adjustment of the periodicity Ip and Lp of the blister strip 21 and the line arrangements of the receiving compartments 12 of the transport board 13, it is always possible to place on each of the holding compartments 12 'central' a yard 23 of the running along the receiving compartment row strip-fenblisters and this central arrangement dispense the medicament contained in the farm 26 in the immediately below orderly receiving compartment 12 of the transport board 13 of the weekly blister. 11

For output control of medication from the Streifenblistern 21 in the receiving compartments 12 of the transport board 13 16 seven perpendicular to the opening plane of the receiving compartments 12 of the transport board 13 are up per output station and down movable ejector plunger 27 is provided, betätig to their ejection ung a pneumatic actuating cylinder, depending is provided 28/1 to 28/7.

The actuating cylinder 28 of the respective output station 16 are arranged in identical form so that their central longitudinal axes 29, which are also the central longitudinal axes of the ejection ram 27, a perpendicular to the opening plane of the transport boards 13 and at right angles transversely to the transport direction of the transport boards 13 extending longitudinal center plane 31 (Figure span .1) of the respective output station.

For the purpose of explanation, it is initially assumed that the actuating cylinders 1.28 to 7.28 can be actuated simultaneously to several and in any combination, both separately at different times as well. Furthermore, it is assumed that the actuating cylinders have a return spring 32 which urges the piston 33 of the respective actuating cylinder 28, and hence the respective ram 27 in its upper end position as the basic position in which the respective Betätig ungsstössel 27 from the respectively associated receiving compartment 12 of a to be equipped transport board is disengaged 13 and its free end face 34, which suitably has a fit adapted to the shape of the ejected medicament, for example, to its shape is approximately complementary concave shape, is arranged at a vertical distance from the outer sides of the blister 23, so that a blister strip 21 without hindrance between a to be assembled transport board 13 and arranged above this actuating cylinders of the delivery station can be moved in its output positions 16 28, which, if necessary, several times back-and-forth process of Streifenblisters 21 at output station 16 erf can order.

The relevant need, for example, provided when a drug is not to take any day of the week, but for example only Monday, Wednesday and Friday and should be avoided that are transported by a continuous further transportation of the respective Streifenblisters drugs via the output station addition and thereby either considerable effort for the recovery of these drugs must be driven or their loss would be accepted. In order to realize in this case with the smallest possible transport or time the appropriate output control, conveniently, the procedure is as follows:

To illustrate assumed in the Fig. 2a illustrated configuration, an output station 16, in which all the farms of Streifenblisters 21, which are arranged as shown to the right of the court 23 of the arranged below the plunger 27 at the leftmost, such , B. Monday associated actuating cylinder 28/1 arranged farm is 23, including this court itself, nor the tion at this Ausgabesta- 17 be provided medication delivery unit contained, viewed in the conveying direction of the Streifenblisters 21, however, all originally left of the below the slide 27 of "Monday" -Betätigungszylinders 28/1 arranged drug delivery units have been previously issued.

In this "initial" configuration of "Monday" cylinder 28/1 is operated first, thereby the medicament contained in the leftmost arranged according the representation of FIG. 2a in the yard arranged thereunder "Monday" -Aufnahmefach 12 transport board is output. 13 After the ram 27 of the ejection cylinder 28/1 comes out of engagement with the Transportblisters 21, it is retracted so far in the direction of arrow 36 "to the right" until the now arranged farthest to the left, even a drug containing Hof 23 is arranged below the plunger 27 of the associated ejection Wednesday 28/3 cylinder which is operated thereto. For the next ejection cycle of the blister 21 is pulled back to the now left most reasonable arranged, still filled yard is disposed under the ram of the associated Friday ejection cylinder 28/5, whereupon the latter is actuated. After initially last edition pressing the blister strip 21 can remain in the now occupied position and are transported in a subsequent dispensing cycle in the appropriate for this best starting position.

For - statistically more significant - the case that in each case all seven receiving compartments will be equipped 12 with the output-drug of this station 16 at an output station 17, is a simple type of output control as follows available:

For an explanation of the configuration illustrated in Fig. 2a by dispensing station 16 and blister strip 21 is again assumed. In the given hereinafter "the beginning" configuration all seven Betätigungszy- be relieving 1.28 to 7.28 activated along with the execution of the ejection stroke of their Auswerfstössel 27 and thereafter immediately driven back to run the Rückzugshubes in its illustrated basic position. The given after the execution of the discharge stroke of the Streifenblisters configuration 21 is shown in Fig. 2b. Each ejected dosage unit - tablet or dragee - is now in one of the related to the time of day in the illustrated embodiment four receiving multiple lines of the transport board 13. After the further transport of the transport board 13 by z. For example, a "day" -Schrittweite the amount b / 4 (Fig.1) and further transport of the Streifenblisters 21 with respect to the output station a periodicity length of the yard arrangement, the configuration of the Streifenblisters 21 shown in Fig. 2c results with respect to the initial transfer station 16, in which the next based on the time of day receiving tray transport line of the board can now once again be filled 13 with one administration unit of the drug provided at the output station by common actuation of the actuating cylinder 28/1. The hereinafter given configuration of Streifenblisters 21 is illustrated in a simplified schematic representation fig.D.

Again repeating the above-mentioned transport and indexing steps eventually lead to the in Figure 2e. Illustrated configuration of the Streifenblisters 21, which requires now a transport displacement of the Streifenblisters to the designated in Fig. 2e St transport path, so that again the Streifenblister- adopted as the starting position position is achieved, can be started in again with the described dispensing cycles.

Control signals for the Figures 1 and 2 only schematically illustrated electromechanical plunging drives 36, by which the blister strip. 21 -. Transverse to the transport direction of the transport boards 13 - formed for the individual, through the pneumatic discharge cylinder 1.28 to 7.28 dispensing stations 16 transported and the cylinders are, as undeliverable and, if necessary also limited backward movements are controllable as well as control signals for the solenoid valves 37, by means of which 1.28 to 7.28 individually, the discharge cylinder or several, possibly all at the same time, subjected to pressure from an unillustrated compressed air source or are pressure-relieved by execution of your working stroke again, and other control signals for electromechanical auxiliary drives 38, which are usable for transporting away emptied blister sections and / or for tensioning the strip-fenblister below the Ausstroßzylinder 01.28 to 07.28, by means of the Ausgabest ation 16 generates individually associated electronic control units 41, which are controllable in the signal generation operation in the stroke of the feed-transport motion of the transport boards 13, such that the phases of operation of the electronic control units are, as synchronized by the transport timing of the transport device 14 41st The transport device 14 is expediently designed as a pawl, with short transport-phase and opposite this time much longer standstill phases, wherein each transport clock each next "row" - group of seven receiving compartments 12 - a dispensing position beneath the dispensing cylinder 28/1 to 28 / 7 of the respective output station 16 passes.

The electronic control units 41 of the dispensing stations 16 generate the control signals for the blister infeed 36, the control valves 37 of the discharge cylinder 01/28 to 07/28, and for the respective auxiliary drives 38 of the output station 16 of a processing of patient-related data into a machine readable form are stored in a data carrier which is associated with one transport board "fixed" and as it is carried along by the latter. The disk contains coded in suitable form, for. B. as a binary number, the designation of the drug that is to be outputted to the addressed output station sixteenth Through this information, the corresponding output station 16 is addressed as it were, that is prepared for a dispensing cycle. Accordingly, an only schematically indicated in Figure 1 the read head 42 (i) with respect to its associated output station 16i. [(I = 1 ... n; n = number of dispensing stations of the system 10)] disposed so that between the reading of the information and the response to be controlled dispensing station 16 (i) there is sufficient time for a reliable processing of the information data.

In the chosen way of illustration specific embodiment 1, the data carrier 43 on the one hand, according to FIG. Left, extending in transport direction transverse edge of the respective transport board 13 is arranged. time - - In addition to the identification of the particular medicament and the patient individualizing data, and are on the disk 43 containing data pattern administration machine readable stored.

In the described arrangement of sense head 42i and output station 16i is the time window to be operated within which the ejection cylinder 1/28 to 7/28 of the respective output station 16, determined by the number of indexing steps of the transport device 14, by which the read head 42 before the each receiving compartment row is happened to be assembled as the receiving compartments at the dispensing station with the respective drug.

The control of the infeed of the blister strip 21 is illustrated for the selected explanatory example with reference to the function of the control and drive elements thereon involved, the implementation of apparatus hereinafter is possible for the skilled person in many ways; accordingly, should be addressed to on apparatus details only insofar as they are specific to the inventive assembly plant 10th

The "response" - Preparing the mounting-operation phase at a selected output station 16i - takes place by the 41 i to be processed information signals from the electronic control unit, by means of this electronic control unit 41 i associated read head are 42i already read into this, while the to be assembled at the dispensing station 16i transport board 13 still in the region of those output station 16 (i -1) is, which is seen in the transport direction, arranged in front of the output station 16i.

That the peelable from the supply roll 22i blister strip 21 i may if the output station does not turn yet operates 16i in the mounting operation, transport plate 13 of the mounting operation for the still at the station 16 (i-1) located Even in this situation, thereby to be prepared, in which for example, the position shown in Fig. 2a, which would require for the reference to the Figure 2a-2e-described function as a displacement of the Streifenbli- sers 21 i by the distance St (Figure 2e) for the mounting operation proper starting position is transported.

Based on the i read into the control unit 41 data, this generates the set of control signals that trigger the advance and retreat motions of the blister strip, which at the various administration times - running associated "line" tracks - morning, noon, evening, night must be, and the data for the selection to be activated out cylinder. The output of this data representing control signals are then balanced-controlled by electrical signals that execution with the indexing motion of the transport boards 13 tion are continuously generated. Here, the various also be executed within a game output the output station 16i in alternating directions movements are determined according to amount and direction.

For detection of the transport path running in a predetermined direction, an "incremental" in FIG. 3a schematically represented, designated as a whole with 44 measuring system is provided for each back-laid in a predetermined direction "small" path increment a count pulse to the electronic control unit 41 i emits the supply device depending on the movement - are summed with positive or negative sign, so that sufficient enough within a game output sum is a measure of the length of this withdrawn Streifenblisters - forward / backward.

In Fig. 3a is a simple realization possibility of an incremental position measuring system indicated by the fact that are provided along an edge strip 46 of the respect of its movements to be tracked Streifenblisters 21 at a small distance .DELTA.S consecutive "prime" marks 47 or more simply arranged schematically to a sensors 48 of a fixedly arranged measuring head 49 by contact to thereby trigger the generation of a count. As a side marks 47 are visually easily recognizable perforations, but also from the magnetic tape technology known magnetic markers that detected with standard reading heads and can be used to output incremental counts.

A suitable for an inventive Bestücksanlage incremental displacement measuring system 51, as shown in FIG. Be formed as an "autonomous" functional unit, which manages at the respective blister strip 21 without marking measures 3b can be removed, alternatively.

The measuring system 51 gem. FIG. 3b has two about parallel axes 52 and 53 of freely rotatable rollers 54 and 56 which are arranged opposite to each other with a minimum force pressed against the opposite edge strips delimiting surfaces of the Streifenblisters 21 and are coupled for movement with these frictionally. The one according to the illustrated embodiment, upper sliding roller 52 is connected via a flat peripheral ring with a pinion 57 of smaller diameter in positively engaged, which in turn is rotationally connected with an impeller 58, the wings 59 for the purpose of generation of counting pulses for interrupting light barriers or can be used a position-dependent detuning of inductive sensor circuits, is capable of achieving a quasi high resolution division of the blister strip-displacement path into a plurality of distance increments by the use of suitable gear ratios, which are the absolute value small compared with the extension of the blister 23 in the transport direction.

By means of the peripheral ring, with which the slide roller 54 is supported on the edge strip of the Streifenblisters 21 is also achieved a form fit acting engagement of the roller 54 with the blister strip 21 due to a constantly existing flexibility of the blister material, which allows a precise displacement measurement.

Also, the temporarily withdrawing a temporarily pushing strip-fenblisterantrieb used drive and guide rollers 60 and 61 of the delivery drive 36, as well as the drive and guide rollers 62 and 63 (Fig. 2a) of auxiliary drives 38 are expediently with "flat", ie provided radially only slightly extended and formed in substantially edge-free sets of teeth, which can reach a quasi-positive engagement with this due to an elastic deformation of the carrier material of the blister strip 21, which promotes the transport reliability.

If the position control and monitoring an incremental measuring system is used, it is necessary from time to time for a defined, selected reference position with a defi ned at the selected arrangement and configuration of the incremental encoder system used Meter is linked to be able to generate characteristic indication signal, to check on the basis of the occurrence of this signal, whether the measurement system has also reached those count which must be present in the detected signal by the position of the Streifenblisters. In the case of a deviation the occurrence of see positionscharakteristi- signal can be used to make a "To" -Eichung of the measuring system characterized in that the counter of the measuring system is set to the position characteristic value. Conveniently, such a recalibration or verification is always carried out automatically when the blister strip has reached the reference position.

In the illustrated explanatory embodiment for generating the reference mark display signal (Fig. 2a) is a light barrier with a total 64 designated used at the interruption by the blister the characteristic position reference signal is generated. This signal occurs, has been cut off from the above by means of a total of 66 sawn recorded cutting device a spent tail of Streifenblisters 21 interrupts the sensor light current of the light barrier 64 as soon as a free transverse edge of the "used" strip-fenblister-end portion.

It is understood that suitable reference marks may be set in other ways, for example in that a perforation hole is punched "somewhere" on the edge of Blisterträgers can pass through for the purpose of triggering a position indicating signal of the sensor light power of a light barrier. Also prints that are visually detek- tierbar, or inductively detectable metal marks can be used appropriately as reference marks.

It is expedient if, viewed in the transport direction, the position of the detected Streifenblisters 21 both prior to entering the dispensing station 16 and after exiting the same, that can be used to output a "calibration" -Kontrollsignals.

be able to detect the ability to feed and any retraction movement of the blister strip 21 and control both in absolute value and in terms of speed, wherein a compound represented by the detailed representation of Fig. 4a design of a mounting system according to the invention to an automatic transition from a supply roll used 22/1 to 22/2 a second supply roll so that at an output station 16, the two supply rolls are associated 22/1 and 22/2, after exhaustion of the Blistervorrates at the first use supply roll to the use 22/1 of the wound on the second supply roll 22/2 blister strip-supply can be passed, without the pick and place operation of the mounting system 10 to interrupt.

A provided for this purpose, generally designated 68 switching conveyed here the function that once the Streifenblistervorrat which can be withdrawn from the supply roll 22/1, is exhausted, is switched to Abzie- hen the Streifenblisters 21 from the second supply roll 22/2 and a common transport both blister strip is achieved 21/1 and 21/2, so that the free "rear" end 69 of "spent" Streifenblisters 21/1 and the free "initial" -Stirnseite 71 of the then-to-use Streifenblisters 21 / are brought together into abutment and 2, while the end portion of the exhausted Streifenblisters 21/1 and the beginning portion of the succeeding Streifenblisters 21/2 through the output station 16 pass to be transported, are held adjacent to each other, until the transition to the second blister strip 21/2 completely has been completed and thereafter sufficient time is available to at the considered Ausgabestati on 16 to be able to replace it with a new supply roll, which is then used when the other storage roll 22/1 is exhausted "used" storage roll 22/1.

A device suitable for implementation of these functions design of the switching device 68 is again illustrated by the functions of sub-units of the switching device by which an expert in precision engineering and control technology can realize the changeover device 68 so that the explanation of design details will be omitted.

The switching device 68 consists essentially of a generally designated 72 'Y'-guiding system comprising two each of the two blister strip 21/1 and 21/2 associated guide branches 73/1 and 73/2 and these each individually associated with transport drives 74/1 and includes 74/2, and a from the union of the two guide branches arising and secondary 73/1 and 73/2 73/3 guide branch includes, over which the 22/1 and 22/2 peelable from the various supply rolls blister strip-strands by means of the ZuStellantriebes 36 are alternatively transported to the output station sixteenth

The transport drives 74/1 and-74/38 2 may be substantially the same way as to its structure and of the respective drive concept used with the ZuStellantrieben 36 and the other auxiliary drives; However, these transport drives should be so controlled 74/1 and 74/2, that they are at least temporarily operated with a higher transport speed than the respective subsequent feed drive 36, the following the transport speed of the respectively used Streifenblisters in the combined guide branch 73/3 and in the determines output station 16, so that the blister strip one end portion that has been stripped from the exhausted supply roll 22/1 or 22/2, following initial portions of einzufädelnden Streifenblisters 21/2 or 21/1-adjusted the end portion of the guide portion 73 verei- / 3 came Streifenblisters speak, that can be brought to bear with this, so that these blister strip, as it "continuously" continue each other dreams and a gap in the used for the assembly of the medication cartridge 11 blister is avoided 23 in the output station 16, "catch up".

In the chosen embodiment for explaining the transport drives have 74/1 and 74/2 each have a "smooth" on the output side 76 of the blister strip 21/1 and 21/2, respectively to guide element-free sections of the switching device 68 arranged at an only schematically indicated rack 77 freely rotatable about parallel to the rotational axes of the supply rolls 22/1 and 22/2 extending axes mounted 78/1 and 78/2 rollers 79/1 and 79/2, the expressed over the entire width of the reasonable to them blister strip 21/1 and 21/2 extend, as well as by non-illustrated electric motor driven drive rollers 81/1 and 81/2, which are the sliding rollers 79/1 and 79/2 disposed opposite and at an edge strip of the sliding rollers 79/1 and 79/2 82/1 and 82/2 opposite Hofsei- th of the blister strip 21/1 or 21/2 able to pass, with the drive rollers 81/1, 81/2 in frictional or non-positive form-fitting, essentially, d h apart by elastic deformation, are slip-free engagement.

When reproduced by Figures 5a -. Expedient - design of the transport drives 74/1 and 74/2 the drive rollers 81 are so constructed and arranged that they only one of the two edge strips 83/1 or 83/2 of the respective Streifenblisters 21 attack, between which the blister pockets 23 are arranged, wherein the blister strip 21 are respectively formed symmet- driven with respect to its longitudinal center planes 84 which extend between the edge strips 83/1 and 83/2.

In accordance with Fig. 4a to the ZuStellantrieben 36 coming guide branches 73/3 of the "Y" -Führungssysteme 72 are, as shown in FIG. 5b immediately ER- arranged, each by a pair of "U" profiles 86/1 and 86 / 2 is formed which, with their parallel legs 87/1 and 87/2 facing each other arranged so that the clear, "horizontal" distance between their yoke-leg 88, except for a slight displacement required for the play of the blister strip width bs of the blister strip 21 corresponds, wherein DIE se guide U-profiles 86/1 and 86/2, the edge strips enclose 83/1 and 83/2 of the blister strip on the largest part of the edge strip width; the clear distance af the courtyard side narrow end edges 89 of the courtyard side U-profile legs 87/1 is sufficiently dimensioned that the blister 23 can not touch the guide profiles.

The "vertical" distance of the mutually parallel profiled leg 87/1 and 87/2 of the guide U-profiles 86/1 and 86/2 is slightly, eg. B. 10% to 20%, greater than the sum of the thicknesses of the guide edge strips 83/1 and 83/2 of the blister strip 21/1 and 21/2 and the blister 23 "downward" final blister cover strip 91, so that although a smooth sliding of the blister strip 21/1 or 21/2 73/3 of the respective "Y '-Führungssystems is ensured 72 in the horizontal Vereini- confining guide path, an overlap of two blister strip in the region of an end portion of a dispensing station in the area arranged Streifenblisters "nachgeschoben" with an initial area of ​​a Streifenblisters however reliably excluded.

The structure which extends between the transport drives 74/1 and 74/2, on the one hand and the junction 92 of the respective "Y" -Führungssystems 72, on the other hand extending guide branches 73/1 and 73/2 is analogous to that of the merging portion 73/3, wherein provided. 5b for the realization of the immediately leading to the dispensing station 16 guide branch 73/3 instead of U-profiles as shown in FIG, for the realization of the "convergent" superposed guide branches 73/1 and 73/2 also simple angle profile 93 ( 5c) can be used Fig., which are mounted on facing sides of frame plates 94/1 and 94/2, which form housing elements of a switching device 68 formed as a functional module.

The for the construction of Υ "72 Executed -Führungssystems applies mutatis mutandis for a designated overall by 96" vertical "connection guide, by means of which the from one supply roll 22/1 peelable blister strip is 21/1 fed to the associated transport drive 74/1 of the switching device , also as well as in Fig. 4a "horizontal" connection guide 97 through which the peelable from the second supply roll 22/2 21/2 blister strip the associated transport drive the Umschaltein- direction is supplied to 74/2 68th these terminal guides 96 and 97 are advantageously realized as part of the switching device 68th

In the illustrated explanatory version of the switching device 68, the connection guides are equipped 96 and 97 with schematically shown as a photoelectric end sensors 98/1 and 98/2, which release an analyzable for controlling the plant 10 output signal when the end of a respective one of the supply roll withdrawn Streifenblisters 21/1 or 21/2 a barrier light beam releases - no longer occludes - or produce a characteristic for the interruption of the light beam barrier signal when the beginning of a peel-off of the respective roller Streifenblisters shades the barrier light beam ,

These signals can be used with a calibration or checking the displays of encoders, such as z. as explained with reference to Figures 3a and 3b according to the basic idea.

A suitable for detecting the position of a Streifenblisters light barrier arrangement 99 may be 4b schematically dargestell- th structure implemented with the in the Fig., In which the barrier light beam is released 101, if it can pass 23 through the gap between two blister courts, by the blister but even largely obscured. By evaluating a sequence of detector output signals of this light barrier arrangement 99 in correlation to encoder output signals described with an arrangement as described with reference to FIG. 3b, are obtainable, can be the end of the Streifenblisters 21/1 or 21/2 very accurately determine, of course taking into account the geometrical dimensions of the system 10 and its output stations sixteenth

In a shown in Figs. 6a to 6d, the typical design of Streifenblistem 21 are the courts 23, which receive the medicines, configured as a one-sided trough-shaped protrusions 102 of a gene from a durchsichti- existing plastic material strip 100. These protrusions 102 are for. B. achieved by deep drawing of the thermoplastic voraussetzbaren plastic material, wherein a material weakening enters in the region of the bulges such that the trough-shaped regions have a compliant, limp consistency, so that they output cylinder 28 are easily deformed by means of the plunger 27, while the rest "e - surrounded "strip area, which is the used to transport longitudinal edge strips 46 and the openings 103 of the courtyards bordered 23, have a stiffer, flexural elastic consistency. These openings are covered during ready to use prepared by a blister strip 21, generally designated 104 covering strip on which the point-forming, clear plastic strip is fixed cohesively 100 after the drugs are inserted in the trough-shaped bulges.

Also, the cover strip 104 is suitably made of a plastic material which is flexurally elastic in the intended dimensions.

According to Fig. 6c of the cover strip 104 is narrower than the trough-forming plastic strip 100, but wide enough to allow the trays openings 103 are disposed completely within the tape width of the cover strip 104. The cover strip 104 is provided, in each case in the region of the trough openings 103 covering areas with narrow longitudinal slots 106/1 and 106/2, and between these extending transverse slots 107, which in the illustrated for explanation, specific embodiment, in the region of the respective opening 103 which the Fig. 6c removable H-shaped slit image shown that symmetrically relative to the longitudinal median plane 108 of the Streifenblisters 21 and each also symmetrical with respect to the transverse central plane 109 (FIG. 6b) of the respective Blisterhofes 23 is.

The material-locking fixing of the cover strip 104 at the point-forming plastic strip 100 is realized such that a solid integral connection between the two plastic strip only in the region of the longitudinal edge strips 111/1 and 111/2 of the cover strip as well as in the field of cross bands 112 of the cover strip is added 100, which extend between adjacently arranged in the longitudinal direction blister 23rd

In this way, in each case the two remain through the transverse slot 107 against each remote rectangular wings 113/1 and 113/2, the covering coplanar running, the tub opening 103, movable and can, when the respective extrusion cylinder is operated to open in the manner of a hinged door ( Fig. 6d) through which emerge the respective drug and displayed in case of a layout of the plant as shown in Fig. 2a, can be discharged into the receiving tray arranged the transport board 13.

In the course of the withdrawal of the ejector plunger 27 in its initial position and the two "door" wing 113/1 and 113/2 reach due to their elasticity to their original positions, in which they further transport of the Streifenblisters 21, which in the area of ​​extrusion cylinder can be guided in a U-profile-shaped guide elements, such as with reference to FIG. 5b already explained, do not interfere.

2a, in contrast to the output station 16 of FIG. at the output station 16 of FIG. 7a, may be made to the details of which now made, ejected from the blister strip 21 by means of ejection cylinders 01/28 to 07/28 from the blister pockets 23 medications 122 collected at an intermediate level above the transport board 13 before - be delivered into the receiving compartments 12 of the transport board 13 - preferably simultaneously.

This intermediate level is determined by the arrangement of a generally designated 117 movable top strip, which at a vertical distance from the blister strip 21 below the same and parallel thereto extending immediately above the transport board 13 and in a not specifically shown transverse guide, analogous to that of - hand of Figure 5b described is constructed, is displaced transversely to the transport direction of the circuit board 13..

This cover strip, with the side by side arranged at the respective output station 16 in egg ner line receiving compartments 12 of the transport board 13 can be covered, has a to the cover strip (Fig. 5b and Fig. 6a to 6d) of the Streifenblisters 21 analog design with by H -shaped extending slots bounded wing-shaped flaps 119/1 and 119/2, whereby the periodicity length Lp of the periodic structure of the flaps deck strip 117 corresponds to that of the receiving compartments 12 of the transport board 13 within a row of such compartments. A simplicity not specifically shown, the transport drive for the cover strip 117 is to the effect designed such that the feed pitch of the periodicity length Lp or a natural fraction corresponding to the same, and that the transport controlled from step to step is that during standstill of the cover strip 117 transverse slot 118 between the two cover wings 119/1 and 119/2, which cover at a standstill in each case one of the trays 12, extending in the respective "vertical" longitudinal center plane 121, in which also the transverse slot 107 of the overlying blister strip cover strip into the dispensing position of the Streifenblisters 21 runs.

In the illustrated embodiment, for explaining the periodicity has Lp of the cover strip 117 the double amount of Priorizitätslän- ge of Streifenblisters 21st

In the design of the dispensing station of FIG. 7a, the ink ejected from the respective courtyards 23 of the Streifenblisters drug- lie administration units 122 initially "centered" on the upper side of the cover strip 117 and are of the both sides of the longitudinal center plane 121 disposed edges of the pivotable wing 119/1 and 119/2 of the cover strip 117 supports. The output of the drugs 122 into the underneath of the cover strip 117 disposed receiving compartments 12 of the respective gene transport board 13 is carried in the illustrated embodiment by 90 ° -Schwenkung of. 7a hammer-shaped in the representation of FIG expulsion elements 123, consisting of a in the right portion Fig. 7a basic position shown, in which one to 117 extending housing block are of receiving slots between the Streifenblisterführung and the guide of the cover strip added 124, are pivoted into the position shown in the left part of FIG. 7 expulsion position, in which the medicament 122 falls into between the crowded apart transverse edges 125/1 and 125/2 in the respective receiving compartment, after which the respective initial driving member 123 back to its "vertical" basic position is pivoted back.

To the ejection operation of the expelling members 123 at the selected explanatory example, a common drive is provided, which is realized by means of a double acting pneumatic cylinder 126, by means of which a flat bar 127 on the housing block 124 is moved back and herverschiebbar; This flat bar 127 is provided slotted holes 128 with vertically extending guide with which an entrainment pin of the expulsion elements is 129,123 in slidably-positive engagement, such that taking place with the direction of the double arrow 131 of Fig. 7b "horizontal" forward and backward movements of the flat bar 128 in direction of double arrow 132 of Fig. 7b extending 90 ° -Schwenkbewegungen the expulsion elements are obtained 123rd

To check the function of the output terminal 116 are the output cylinders associated 01/28 to 07/28 individually, in total, respectively with 133 designated photocells (Fig. 7c) are provided whose respective optical axis 134 in the vertical longitudinal mid-plane 121 between the transverse edges 125/1 and 125 / 2 of the wing-shaped flaps 119/1 and 119/2 of "lower" Deckstrei- fen 117 and extends at a clear distance above the same which corresponds to approximately half the diameter of each medicament to be dispensed 122nd

The cover strip 117 made of an elastic material so that the hill-shaped flaps 119/1 and 119/2, after the medication is expelled 122 down, back to their starting position coplanar to snap back, in which the flaps 119/1 and 119/2 again are arranged.

A suitable material may be a resilient plastic, the cover strip 117 may additionally be metallized.

The cover strip 117 is functional element of a quasi integrated into the system 10 means for function control and for quality assurance and should not, in turn, the risk of damage to be exposed. Accordingly, the cover strip is displaceable - "renewable bar" -, such that the output station 16 is at least equipped from time to time with a "new" cover strip portion, wherein the cover strip is cyclically shifted by a periodicity length Lp, for example, after the expiration of ten output cycles of the respective output station, of course, as needed to the effect that a possible damage by a narrowing of the cover strip in the output station area danger is excluded.

The inventive concept with falling placement machines, as previously explained, may be varied in many ways. Not illustrated Asked modifications include the following:

For varied needed medication multiple output modules, each comprising a dispensing station and a supply roll may be provided.

It is also possible a configuration of a mounting system of the invention such that is supplied from a blister supply roll, a double-output station, if a supply roll is sufficient in a mounting system with two assembly lines to serve both assembly lines, in such a case the more frequently used drugs of depending on a supply roll and a dispensing station associated therewith to be supplied.

An appropriate modification may also be that in the design of the matrix rows of the cartridge assembly are associated with the times of the day with two transport lines and the sequence of days, as it corresponds to the columns of the matrix arrangement of the to be mounted parallel pairs of transport boards. 13 In this case, the delivery station has eight ejection elements for the case that the division of the day morning, noon, evening and night is given, which was represented by the matrix rows in reference to FIGS. 1 to 7c-described embodiments.

Claims

claims
1. plant for assembly of packaging units with a plurality of drugs, each corresponding to the weekly requirements of a variety of different patients these drugs in a by date (weekday) and time of day (morning, noon, evening, night) ordered sequence corresponding to a - should take medical prescription, wherein the packing units are arranged in a matrix configuration in lines and columns is receptive compartments for the medicament administration units - - patient-related capsules, tablets, dragees - have, each within the area marked by the arrangement of the compartments within the matrix periods are to be taken from each patient, characterized by the following features: a) there are packaging units (11) individually associated output stations (16) are provided, at which a line-population of all or a subset number of selected compartments (12) takes place automatically; b) there is provided a longitudinal conveyor (14), by means of which the packaging units (11) in a predetermined direction sequentially to the individually different agents associated output stations (16) are transported; c) supplying the drug-Verabreichseinheiten to the dispensing stations is effected by means of the drugs individually associated cross conveyors; d) the longitudinal transporting device (14) and the transverse conveying devices (36, 38) with respect to transport stroke and Förderkapazi- ty to the effect matched that pro - erfolgendem in the column direction of the receiving compartment arrangement - transport stroke of the packaging units (11) and pro - in the row direction erfolgendem the receiving compartment arrangement - conveying stroke of the transverse conveying a sequentially line-wise loading of the receiving compartments (12) is achievable, which is in each case in synchronized stoppage phases of the longitudinal conveyor and transverse conveyor cycles; e) (to control the dispensing stations 16) in the sense of prescription-oriented drug loading of the packing units (11), an electronic control unit (41) is provided which generates understood that the necessary control signals from processing of information signals, which information about the patient and include the respectively associated therewith contents of the packaging units and the control unit (41) synchronized with the feed rate in a movement of the packaging units (11) and are fed continuously to the patient uniquely associated sequence.
2. Assembly system according to claim 1, characterized in that these assigned data carriers are provided in a spatially defined configuration with respect to the packaging units (11), which contain the patient-related data in machine-readable form.
3. Assembly system according to claim 2, characterized in that reading stations (42) for the data carriers of the packaging units to the delivery stations (16) are provided and are integrated therein.
Assembly plant according to claim 2 or claim 3, characterized in that for a dispensing station (16) provided LE sestation (42) is arranged, seen in the transport direction of the packaging units (11), on a arranged in front of the controlled output station output station (16) ,
5. Assembly system according to one of claims 1 to 4, characterized in that the packaging units (11) have printable areas on which by means of the output stations (16) - preferably individually - associated printing devices of protocol information in particular running at the dispensing station operations up printable are.
6. Assembly system according to one of claims 1 to 5, characterized in that the administration units - tablets, capsules, dragees - are arranged equidistantly on Streifenblistem (21) wound on a supply roll (22) and are removable from this that between the supply reels (22) and the output stations (16) transporting drives for the transverse conveyance of the blister strip (21) are arranged, and that the output stations (16) in the direction of transport of the blister strip (21) seen successively arranged off pushers (28) have, by means of which the medication from the blister pockets (23) are ejectable and in the receiving compartments (12) of packing units (11) can be output.
7. Assembly system according to claim 6, characterized in that the distance Lp (28) corresponds to each of adjacent discharge units an integral multiple of the distance Ip of adjacent blister pockets (23) of the respective Streifenblisters (21).
8. Assembly system according to claim 6 or claim 7, characterized indicates overall that the ejection units (28) are designed as pneumatic linear cylinders.
9. Assembly system according to claim 8, characterized in that from the housing of the pneumatic cylinders (28) projecting piston days are provided with tappet heads that have an approximately complementary to the ejected drug-concave shape.
10. Assembly system according to one of claims 6 to 9, characterized in that have the blister strip (21), preferably on both sides of a strip-shaped middle region in which the blister cavities (23) are arranged extending edge strips (83/1 and 83/2) to de- NEN the drive means (36, 38) engage.
11. Assembly plant according to claim 10, characterized in that for the transport guide of the blister strip (21) whose edge strips (83/1 and 83/2) at least partially engages around the U profile-shaped guide elements (86/1 and 86/2) are provided on both sides provide an interlocking guidance of the blister strip (21) of drive means.
12. Assembly plant according to claim 10 or claim 11, characterized in that the clear distance of the mutually parallel guide arms (87/1 and 87/2) of the U-profiles (86/1 and 86/2) is less than twice the thickness of the edge strips of the blister strip.
13. Assembly system according to one of claims 6 to 12, characterized indicates overall that the blister strip (21), the yards (23) for the drug-forming plastic strip (100), and flexurally elastic, the Hof-openings (103) covering cover strip ( 104) have, which are provided in the region of the openings with the ejection of the medication facilitating embossments and / or perforations and / or narrow slits.
14. Assembly plant according to claim 13, characterized in that the embossments extend and / or slots H-shaped, with a transverse slot (107) are mutually offset, and by longitudinal slits (106/1 and 106/2) against the edge strip (47) of the strip-deposited fenblisters (21) cover wings (113/1 and 113/2) in the manner of a hinged door opening and reclosing top flaps form.
15. Assembly system according to one of claims 6 to 14, characterized in that at a vertical distance (h) of the strip-fenblisterführung to this running parallel, at a level between the Streifenblistern (21) and the transporting guide for the packaging unit (11 ) has a guide for a movable cover strip (117) is arranged, which is also provided with the release of Durchtrittsöff- voltages facilitating embossments, perforations or slots and means (123,126,127) for opening operation of bordered by such embossings, perforations and / or slits top flaps is.
16. Assembly plant according to claim 15, characterized in that arranged on the intermediate level cover strip (117) has the same periodicity length Lp how the blister strip (21) and per output cycle that takes place at the respective delivery station, after which by a defined distance, preferably one of the periodicity length Lp corresponding step is transported automatically.
17. Assembly plant according to claim 15 or claim 16, characterized in that provided at least 90 ° pivoting, L- or T-shaped release elements (123) from a basic position, in which between the blister strip (21) and the guide for the cover strip (117) extending, vertical passage channels of a housing block (124) are released, can be swiveled into a position are bar in the blocked these channels and the medicaments arranged in the underneath of the cover strip (117) compartments (12) of the respective packaging unit (11) are output.
18. Assembly plant according to claim 17, characterized in that a device to form a common opening actuation of the release elements (123) is provided.
19. Assembly system according to one of claims 6 to 18, characterized indicates overall that as drives for the transverse conveyance of the blister strip (21) pairs of rollers are provided, which attacking at least one of the edge strips of the Streifenblisters, with drive and sliding rollers on the respective supported edge strip and impart thrust by frictional connection and / or positive fit the conversion of drive force into forward.
20. Assembly plant according to claim 19, characterized in that drive elements are provided which are designed in the manner of toothed pinions with smoothly curved perforations, the lastizität convey the blister material a positively acting engagement therewith due to the E-.
21, mounting device according to any one of claims 6 to 20, characterized in that for position detection of the blister strip (21) of domestic krementale - counting successively covered path sections of equal length - displacement sensor (51) are provided.
22. Assembly system according to one of claims 6 to 21, characterized in that the edge markings of the blister strip (21) erfas- transmit position sensors are provided to indicate by their output signals, a defined position of the respective Streifenblisters (21).
23. Assembly plant according to claim 21, characterized in that the edge markings releasing cutting or punching means are provided, which are arranged at a defined distance from the output station (16) in the region of the blister guide devices.
24. loading device according to claim 22 or claim 23, characterized in that, in the transporting direction of the blister strip (21) seen in each case at least one marking device on this side of the delivery station (16) is provided, and at least one marking device beyond the dispensing station (16) is arranged.
25. Assembly plant according to claim 24, characterized in that, seen in the transport direction of the respective Streifenblisters (21), beyond the output station (16) a cutting station (66) for separating the emptied end section of the Streifenblisters (21) is arranged.
26. Assembly system according to one of claims 1 to 25, characterized indicates overall that sensor devices are provided that check whether medicaments are present, and detectors are provided that recognize that medicaments have been issued.
27. Assembly plant according to claim 26, characterized in that the detection of medicaments in the respective delivery station (16) is carried on the intermediate level, which is marked by the arrangement of the transportable cover strip (117) (the receiving compartments (12) of the respective transport board 13) controlled covers releasably.
28. Assembly plant according to claim 26, characterized in that viewed in the transport direction of the blister strip (21), in front of and beyond the dispensing stations (16), the presence of drugs in the blister pockets (23) recognizing the sensors and / or detectors are provided.
29. Assembly plant according to claim 22, characterized in that the sensors and / or the detectors are realized as light barriers.
30. Assembly system according to one of claims 1 to 29, characterized in that at least two delivery stations (16) are provided for medicaments whose statistical requirement is sig- nificantly higher than the average requirement.
31. Assembly plant according to claim 30, characterized in that several, provided for the same medicament Ausgabestatio- nen are each arranged directly adjacent to each other.
32. Assembly system according to one of claims 1 to 31, characterized in that two - parallel - transporting systems are provided for packaging units, in which assigned for statistically relatively rarely th needed medication (2), each system output stations arranged side by side and by means of a common cross conveyor can be supplied, and the statistically more commonly required medicaments each have their own transverse conveyor is assigned to the drug supply / are.
33. Assembly system according to one of claims 1 to 32, characterized in that the longitudinal transportation of the packaging units takes place in groups, wherein the a group summarized packaging with the same transport speed and the same pitches are moved, but can be different, these speeds or step sizes and between successive groups of packaging units free buffer zones are provided to allow the relative movement of the mutually adjacent groups.
34. Assembly system according to one of claims 1 to 33, characterized indicates overall that provided for receiving the medication packaging a have the receiving compartments forming deep-drawn part each consisting of a first workstation of a transporting stretch of the assembly plant (10) forming deep-drawing station is made and from the latter but required rework to the output stations of the system is necessary to transport.
EP05706833A 2004-04-26 2005-01-03 Installation for filling packaging units with medicaments for patients according to the prescribed weekly requirements Expired - Fee Related EP1740459B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE200410020510 DE102004020510B4 (en) 2004-04-26 2004-04-26 Plant for the assembly of packing units with the proper prescription week needs of patients corresponding medicaments
PCT/EP2005/000002 WO2005102841A1 (en) 2004-04-26 2005-01-03 Installation for filling packaging units with medicaments for patients according to the prescribed weekly requirements

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08101316A EP1916187B1 (en) 2004-04-26 2005-01-03 Device for filling packaging units with patients' weekly required supply of medicine
DK08101316.1T DK1916187T3 (en) 2004-04-26 2005-01-03 Facilities for the supply of packaging units of the patients according to the prescription needs of medicaments weekly

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP08101316A Division EP1916187B1 (en) 2004-04-26 2005-01-03 Device for filling packaging units with patients' weekly required supply of medicine

Publications (2)

Publication Number Publication Date
EP1740459A1 true EP1740459A1 (en) 2007-01-10
EP1740459B1 EP1740459B1 (en) 2008-07-23

Family

ID=34960027

Family Applications (2)

Application Number Title Priority Date Filing Date
EP08101316A Expired - Fee Related EP1916187B1 (en) 2004-04-26 2005-01-03 Device for filling packaging units with patients' weekly required supply of medicine
EP05706833A Expired - Fee Related EP1740459B1 (en) 2004-04-26 2005-01-03 Installation for filling packaging units with medicaments for patients according to the prescribed weekly requirements

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP08101316A Expired - Fee Related EP1916187B1 (en) 2004-04-26 2005-01-03 Device for filling packaging units with patients' weekly required supply of medicine

Country Status (10)

Country Link
US (1) US7637079B2 (en)
EP (2) EP1916187B1 (en)
JP (1) JP4568328B2 (en)
AT (2) AT467562T (en)
AU (1) AU2005234853B2 (en)
CA (1) CA2565210C (en)
DE (3) DE102004020510B4 (en)
DK (2) DK1916187T3 (en)
ES (2) ES2310332T3 (en)
WO (1) WO2005102841A1 (en)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7690173B2 (en) 2005-09-30 2010-04-06 Edge Medical, Inc. Multiple prescription production facility
US9334096B2 (en) 2004-10-01 2016-05-10 Edge Medical Properties, Llc Multiple inspection system and method that inspects different medications
US8123036B2 (en) 2004-10-01 2012-02-28 Edge Medical Properties, Llc Pill assembly for pill packaging and delivery systems
US8712582B1 (en) 2004-10-01 2014-04-29 Edge Medical Properties, Llc System and method for combining different tablets into a pouch
US9245304B2 (en) 2004-10-01 2016-01-26 Edge Medical Properties, Llc Manufacturing separable pouches with a center cut blade
US8972288B2 (en) 2004-10-01 2015-03-03 Edge Medical Properties, Llc System and method for online matrix-based dosage scheduling
US9238518B2 (en) 2004-10-01 2016-01-19 Edge Medical Properties, Llc Inspection system and method with a control process that inspects different medications
US9015058B2 (en) 2004-10-01 2015-04-21 Edge Medical Properties, Llc Matrix based dosage scheduling
US10315450B1 (en) 2006-10-24 2019-06-11 Edge Medical Properties, Llc System and method for generating an integrated label for container housing multi-script pouches
US8146747B2 (en) * 2004-10-01 2012-04-03 Edge Medical Properties, Llc Tablet dispensing container
US8266878B2 (en) 2004-10-01 2012-09-18 Edge Medical Properties, Llc System and method for verifying and assembling a multiple prescription package
US9710866B2 (en) 2005-09-30 2017-07-18 Edge Medical, Llc System and method for processing a multiple prescription order
US8789700B2 (en) 2004-10-01 2014-07-29 Edge Medical Properties, Llc System and method for communicating and inspecting a multiple tablet order
US8074426B2 (en) * 2005-09-30 2011-12-13 Edge Medical, Llc Multiple prescription package and method for filling the package
US8914298B1 (en) 2004-10-01 2014-12-16 Edge Medical Properties, Llc System and method for integrated verification and assembly of multi-script pouches into a housing container
EP1800645A1 (en) 2005-12-21 2007-06-27 Körber AG Package for medicinal products and the like
DE102006027521B4 (en) * 2006-06-10 2016-01-07 Edwin Kohl Plant for the personal placement of medication dispensers
ES2340958T3 (en) * 2007-01-22 2010-06-11 Edwin Kohl Blister packaging and procedure for the temporary storage of products.
EP2000410B1 (en) * 2007-05-03 2009-07-22 UHLMANN PAC-SYSTEME GmbH & Co. KG Method for manufacturing supply packs with various medicines for several days
US8943780B1 (en) 2007-05-30 2015-02-03 Walgreen Co. Method and system for verification of product transfer from an intermediate loading cartridge to a multi-container blister pack
EP2062822A1 (en) * 2007-11-24 2009-05-27 UHLMANN PAC-SYSTEME GmbH & Co. KG Method and device for individual filling of blister packages
ES2336880B1 (en) * 2008-04-02 2011-02-10 Marti Garcia Sala dispensing machine for blister type packaging.
US8200366B2 (en) * 2008-08-06 2012-06-12 Walgreen Co. Method and system for determining a volume-based fill pattern of a multi-dose medicament container
US8627639B2 (en) * 2008-09-19 2014-01-14 Walgreen Co. Method and system for determining an order of fill for a plurality of pills in a multi-dose medicament container
EP2343243B1 (en) 2010-01-07 2012-06-13 Uhlmann VisioTec GmbH Assembly for monitored filling of solid pharmaceutical products
US9141764B2 (en) 2010-11-12 2015-09-22 Edge Medical Properties, Llc System and method for online integrated multiple tablet ordering
US8914146B2 (en) 2011-07-11 2014-12-16 Omnicare, Inc. Methods and apparatus for filling of packagings with medications
JP6355881B2 (en) * 2011-08-26 2018-07-11 株式会社タカゾノテクノロジー Drug packaging device
NL2007384C2 (en) * 2011-09-09 2013-03-12 Ppm Engineering B V System and method for packing dosed quantities of solid medicines
DE102011086575B4 (en) 2011-11-17 2015-10-08 Martin Halm Device and method for individual filling of blisters
USD693695S1 (en) 2012-03-28 2013-11-19 Aventisub Ii Inc. Package for product
USD697813S1 (en) 2012-03-28 2014-01-21 Aventisub Ii Inc. Clamshell having blisters received therein
USD695625S1 (en) 2012-03-28 2013-12-17 Aventisub Ii Inc. Package for product
USD687313S1 (en) 2012-03-28 2013-08-06 Aventisub Ii Inc. A-shaped blister card
US8899419B2 (en) 2012-03-28 2014-12-02 Aventisub Ii Inc. Package with break-away clamshell
US8919559B2 (en) 2012-03-28 2014-12-30 Aventisub Ii Inc. Package with break-away clamshell
USD694644S1 (en) 2012-03-28 2013-12-03 Aventisub Ii Inc. Clamshell package having blisters
US9073206B2 (en) 2012-06-21 2015-07-07 Omnicare, Inc. Methods and apparatus for automated filling of packagings with medications
NO2870072T3 (en) 2012-07-05 2018-01-20
PT2879974T (en) 2012-07-30 2017-11-28 P C O A Devices Ltd A receptacle for containing and dispensing solid medicinal pills
US9511945B2 (en) 2012-10-12 2016-12-06 Aesynt Incorporated Apparatuses, systems, and methods for transporting medications from a central pharmacy to a patient in a healthcare facility
ES2620763T3 (en) * 2012-12-04 2017-06-29 Multivac Sepp Haggenmüller Se & Co. Kg Machine for forming deep drawing packaging with precise cycle positioning of a sealing station and corresponding procedure
EP2754614B1 (en) 2013-01-14 2015-06-24 Edwin Kohl System and method for personalised filling of blister packages with drugs
EP2754615B1 (en) * 2013-01-14 2015-07-29 Edwin Kohl System for personalised filling of blister packs with medications according to specified prescription data
US20140230376A1 (en) * 2013-02-18 2014-08-21 Qem, Inc. System, Method, and Apparatus for Forming and Filling Pill Compartments
US9150119B2 (en) 2013-03-15 2015-10-06 Aesynt Incorporated Apparatuses, systems, and methods for anticipating and delivering medications from a central pharmacy to a patient using a track based transport system
ES2626779T3 (en) 2014-09-08 2017-07-26 Edwin Kohl Installation and procedure for repackaging different medicines from their respective original blisters to filling blisters
US10155603B2 (en) * 2015-04-17 2018-12-18 Carefusion Germany 326 Gmbh Apparatus for packaging individual medication doses and method for its operation
US20160332753A1 (en) * 2015-05-13 2016-11-17 Carefusion Germany 326 Gmbh Device for packaging medication portions
US10327994B2 (en) * 2016-05-02 2019-06-25 Dose Pack Llc System and methods for customized medicine dosages in a capsule
FR3074041A1 (en) 2017-11-28 2019-05-31 Distraimed Device and method for preparing a pilular
DE102017130735A1 (en) 2017-12-20 2019-06-27 Delphi Salesconsulting Ag Device for automated modification of the composition of a batch
DE102017130737A1 (en) * 2017-12-20 2019-06-27 Delphi Salesconsulting Ag Method for the automated production of creams

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732544A (en) 1970-11-25 1973-05-08 D Obland Computer-controlled article merchandising system for prescription drugs and like articles
EP1176106B1 (en) 2000-06-30 2006-12-13 Assistance Publique Hopitaux De Paris Process and system for automatically preparing doses of medication according to computerised prescriptions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2339115A (en) * 1940-07-05 1944-01-11 Robert P Scherer Machine for and method of packaging capsules
FR1001466A (en) * 1946-05-15 1952-02-25 Devices for quick filling blister sheet material plastiquedestinées packaging of tablets, troches, pills and other regular shaped products
DE2239344A1 (en) * 1972-08-10 1974-02-28 Hoefliger & Karg Device for the orderly feeding and loading of tablets, dragees or the like
GB8519036D0 (en) * 1985-07-29 1985-09-04 Jefferies F W Blister pack machine
US4655026A (en) * 1985-12-11 1987-04-07 Wigoda Luis T Pill dispensing machine
JP3417961B2 (en) * 1992-07-21 2003-06-16 ローム株式会社 Electronic components of continuous taping equipment
DE9416212U1 (en) * 1994-10-07 1995-02-02 Mu Zhiping Dr Dispenser for consumable products, particularly for medicines, for removal device in a magazine, in particular a dispenser recorded items and packaging for consumable items
US6318051B1 (en) * 1996-12-30 2001-11-20 P+P Materialfluss-Systeme Gmbh Method and device for automatic dispatching of singular items, specially an individual pill
BR0109719B1 (en) * 2000-03-31 2010-11-30 Machine automated solid pharmaceutical packaging.
DE10026331B4 (en) * 2000-05-26 2005-09-01 Robert Bosch Gmbh Apparatus for feeding products
CN1246185C (en) * 2000-06-05 2006-03-22 曼雷克斯股份有限公司 Medication dispenser
US6449921B1 (en) * 2001-04-16 2002-09-17 Jv Medi Co., Ltd. Tablet supplying and packaging apparatus having turntable and tablet cassettes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732544A (en) 1970-11-25 1973-05-08 D Obland Computer-controlled article merchandising system for prescription drugs and like articles
EP1176106B1 (en) 2000-06-30 2006-12-13 Assistance Publique Hopitaux De Paris Process and system for automatically preparing doses of medication according to computerised prescriptions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2005102841A1

Also Published As

Publication number Publication date
DK1916187T3 (en) 2010-08-23
US20080190076A1 (en) 2008-08-14
JP4568328B2 (en) 2010-10-27
ES2310332T3 (en) 2009-01-01
EP1916187A1 (en) 2008-04-30
EP1740459B1 (en) 2008-07-23
AU2005234853A1 (en) 2005-11-03
AT467562T (en) 2010-05-15
DE502005004809D1 (en) 2008-09-04
CA2565210C (en) 2009-08-11
AU2005234853B2 (en) 2009-07-23
DK1740459T3 (en) 2008-11-24
ES2342743T3 (en) 2010-07-13
DE502005009576D1 (en) 2010-06-24
US7637079B2 (en) 2009-12-29
EP1916187B1 (en) 2010-05-12
DE102004020510B4 (en) 2007-11-29
CA2565210A1 (en) 2005-11-03
WO2005102841A1 (en) 2005-11-03
DE102004020510A1 (en) 2005-11-10
AT402075T (en) 2008-08-15
JP2007534568A (en) 2007-11-29

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