EP1732914A1 - Novel process - Google Patents

Novel process

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Publication number
EP1732914A1
EP1732914A1 EP05722256A EP05722256A EP1732914A1 EP 1732914 A1 EP1732914 A1 EP 1732914A1 EP 05722256 A EP05722256 A EP 05722256A EP 05722256 A EP05722256 A EP 05722256A EP 1732914 A1 EP1732914 A1 EP 1732914A1
Authority
EP
European Patent Office
Prior art keywords
formula
alkyl
hydroxy
amino
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05722256A
Other languages
German (de)
French (fr)
Inventor
Abdurrazzaque Mirajkar
Vikas AstraZeneca R & D Bangalore MISHRA
B. Di Venugopalan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Mirajkar Abdurrazzaque
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mirajkar Abdurrazzaque, AstraZeneca AB filed Critical Mirajkar Abdurrazzaque
Publication of EP1732914A1 publication Critical patent/EP1732914A1/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Definitions

  • the present invention provides a novel process for the preparation of chromone compounds having the general formula I:
  • R 1 is selected from H, Ci-ioalkyl, halogen, amino, Ci-ealkyl-oxy, or hydroxy;
  • L is a displaceable group selected from bromo, chloro, fluoro or iodo
  • R 2 is selected from H, C ⁇ - 6 alkyl, halogen, hydroxy, amino, C ⁇ - 6 alkyl-amino, C ⁇ . 6 alkyl- carbonyl, C ⁇ - 6 alkyl-oxy and C ⁇ - 6 alkyl-oxycarbonyl optionally substituted by one or more groups selected from halogen, amino and hydroxy;
  • the present invention relates to the preparation of chromone compounds that may be useful in the manufacture of potentially potent orally active 5-Hti b receptor antagonist, useful in the treatment of depression, anixiety and other related diseases.
  • An example of such a preparation is as follows:
  • Applicants provide a process for the preparation of chromone compounds of formula I that unexpectedly and surprisingly provide improvements in product yields, cost, energy consumption, reduction in the number of synthetic steps, improved scale up conditions, and the like.
  • R 1 is selected from H, Ci-ioalkyl, halogen, amino, C ⁇ - 6 alkyl-oxy, or hydroxy;
  • L is a displaceable group selected from bromo, chloro, fluoro or iodo
  • R 2 is selected from H, Ci- ⁇ alkyl, halogen, hydroxy, amino, C ⁇ - 6 alkyl-amino, C ⁇ - 6 alkyl- carbonyl, C ⁇ - 6 alkyl-oxy and Ci- ⁇ alkyl-oxycarbonyl optionally substituted by one or more groups selected from halogen, amino and hydroxy;
  • R 1 is, independently, H, C]-C 6 alkyl, halogen, hydroxy 1, methoxy or cyano. In a more particular embodiment R 1 is, independently, hydrogen or fluoro.
  • L is a displaceable group.
  • L is a displaceable group selected from bromo, chloro, fluoro or iodo.
  • L is bromo.
  • R 2 is selected from H, C ⁇ a-kyl, halogen, hydroxy, amino or C ⁇ ⁇ alkyl-oxy optionally substituted by one or more groups selected from halogen, amino and hydroxy.
  • R 2 is selected from H, C h alky-, C ⁇ - 6 alkyl-oxy or hydroxy.
  • the above process may further include a step for separating, filtering or washing compounds that may be carried out in any number of ways known in the art.
  • heating the compound of formula Va, the acetylating agent and the catalyst may be conducted at a temperature and for a time effective to provide compound Vb.
  • the heating of formula Va, the acetylating agent and the catalyst may be conducted at a temperature between about 130 and about 135°C for about 1 to 2 hours.
  • the acetylating agent are those functional derivatives of carboxylic acids that contain an acyl group and that can undergo nucleophilic substitution.
  • suitable acetylating agents include acetic acid, acetic anhydride, acetamide, acetyl chloride, acetyl bromide and ethyl acetate.
  • the acetylating agent may be acetyl chloride.
  • the Lewis acid catalyst may be selected from aluminum chloride, zirconium tetrachloride, bromide tetrachloride, HF and phosphoric acid.
  • the Lewis acid catalyst may be selected from aluminum chloride or zirconium tetrachloride.
  • the Lewis acid catalysts may be aluminum chloride.
  • the Lewis acid catalyst may be added in portions.
  • the Lewis acid catalyst may be added in two portions.
  • the pH level may be adjusted. In another embodiment, the pH level may be adjusted to about 7.
  • one of the carbonyl groups forming the dicarbonyl compound may be an ester.
  • suitable dicarbonyl compounds include Pyruvate or glyoxylate esters, methylglyoxal, and C ⁇ - 4 oxalate. In particular, the dicarbonyl compound may be ethyl oxalate.
  • reacting the compound of formula Vb with a dicarbonyl compound in an alcohol solution may be conducted at a temperature and for a time effective to provide compound Vc.
  • the reaction may be conducted at a temperature between about 55 and about 60°C for a time between about 1 to 2 hours.
  • the alcohol solution comprises sodium alkoxide in absolute alcohol.
  • suitable sodium alkoxides include sodium methoxide, sodium ethoxide sodium isopropoxide and sodium tert-butoxide.
  • suitable absolute alcohols include methanol, ethanol, propanol, butanol, isobutanol and tert-butanol.
  • the alcohol solution comprises sodium ethoxide in absolute ethanol.
  • reacting the compound of formula Vc with a mixture of acid may be conducted at a temperature and for a time effective to provide compound I.
  • the reaction may be conducted at a temperature between about 70 and about 80°C for a time between about 1 to 2 hours.
  • the mixture of acids may be a mixture of acetic and hydrochloric acid.
  • Minimizing the charge of aluminum chloride may help control any impurities that form during the above process.
  • alkyl used alone or as a suffix or prefix, refers to monovalent straight or branched chain hydrocarbon radicals comprising 1 to about 12 carbon atoms. Unless otherwise specified, “alkyl” generally includes both saturated alkyl and unsaturated alkyl.
  • cycloalkyl used alone or as suffix or prefix, refers to a monovalent ring- containing hydrocarbon radical comprising at least 3 up to about 12 carbon atoms.
  • aryl used alone or as suffix or prefix, refers to a hydrocarbon radical having one or more polyunsaturated carbon rings having aromatic character, (e.g., 4n + 2 delocalized electrons) and comprising 5 up to about 14 carbon atoms, wherein the radical is located on a carbon of the aromatic ring.
  • heterocycle used alone or as a suffix or prefix, refers to a ring-containing structure or molecule having one or more multivalent heteroatoms, independently selected from N, O, P and S, as a part of the ring structure and including at least 3 and up to about 20 atoms in the ring(s).
  • Heterocycle may be saturated or unsaturated, containing one or more double bonds, and heterocycle may contain more than one ring.
  • the rings may be fused or unfused.
  • Fused rings generally refer to at least two rings share two atoms therebetween.
  • Heterocycle may have aromatic character or may not have aromatic character.
  • alkoxy used alone or as a suffix or prefix, refers to radicals of the general formula -O-R, wherein -R is selected from a hydrocarbon radical.
  • exemplary alkoxy includes methoxy, ethoxy, propoxy, isopropoxy, butoxy, t-butoxy, isobutoxy, cyclopropylmethoxy, allyloxy, and propargyloxy.
  • Halogen includes fluorine, chlorine, bromine and iodine.
  • “Saturated carbon” means a carbon atom in a structure, molecule or group wherein all the bonds connected to this carbon atom are single bond. In other words, there is no double or triple bonds connected to this carbon atom and this carbon atom generally adopts an sp 3 atomic orbital hybridization.
  • "Unsaturated carbon” means a carbon atom in a structure; molecule or group wherein at least one bond connected to this carbon atom is not a single bond. In other words, there is at least one double or triple bond connected to this carbon atom and this carbon atom generally adopts a sp or sp 2 atomic orbital hybridization.
  • the processes and synthetic methods described hereinthroughout may be carried out with or without a suitable solvent or base.
  • suitable solvents are solvents which are substantially non-reactive with the starting materials (reactants), the intermediates, or products at the temperatures at which the reactions are carried out, i.e., temperatures which may range from the solvent's freezing temperature to the solvent's boiling temperature.
  • a given reaction may be carried out in one solvent or a mixture of more than one solvent.
  • suitable solvents for a particular work-up following the reaction may be selected.
  • suitable solvents may include water, alcohols, hydrocarbon solvents and halogenated derivatives.
  • water, dichloromethane, xylene, ethanol and methanol are examples of suitable solvents.
  • the temperature of the mixture was raised to 130-135°C over one hour during which time dichloromethane (80 L) was removed by distillation.
  • the mixture was maintained at 130-135°C for one hour, diluted with xylene (250 L) and cooled to 10-15°C.
  • the reaction mixture was added to a solution of 30% w/w hydrochloric acid (25 L) in water (500 L).
  • the layers were separated and the organic phase was extracted with 10% w/w sodium hydroxide solution (300 L).
  • the aqueous extract was cooled to 10-15°C and adjusted to pH 6.8-7.2 with 30% w/w hydrochloric acid (55.0 kg).

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)

Abstract

Provided herein are novel processes for the preparation of intermediates that may be useful in the preparation of 5-Ht1b receptor antagonist useful in the treatment of depression, anxiety and other related diseases. The present processes may offer improved yields, purity, ease of preparation and isolation of intermediates and final product and more industrially useful reaction conditions and workability.

Description

FIELD OF INVENTION
The present invention provides a novel process for the preparation of chromone compounds having the general formula I:
wherein
R1 is selected from H, Ci-ioalkyl, halogen, amino, Ci-ealkyl-oxy, or hydroxy;
L is a displaceable group selected from bromo, chloro, fluoro or iodo; and
R2 is selected from H, Cι-6alkyl, halogen, hydroxy, amino, Cι-6alkyl-amino, Cι.6alkyl- carbonyl, Cι-6alkyl-oxy and Cι-6alkyl-oxycarbonyl optionally substituted by one or more groups selected from halogen, amino and hydroxy;
BACKGROUND OF THE INVENTION
The present invention relates to the preparation of chromone compounds that may be useful in the manufacture of potentially potent orally active 5-Htib receptor antagonist, useful in the treatment of depression, anixiety and other related diseases. An example of such a preparation is as follows:
X II
While this preparation leads to the chromone compound it also suffers from several drawbacks, making its viability for commercial production doubtful. Applicants provide a process for the preparation of chromone compounds of formula I that unexpectedly and surprisingly provide improvements in product yields, cost, energy consumption, reduction in the number of synthetic steps, improved scale up conditions, and the like.
DESCRIPTION OF THE INVENTION
Provided herein is a process for preparing compounds of formula I:
wherein
R1 is selected from H, Ci-ioalkyl, halogen, amino, Cι-6alkyl-oxy, or hydroxy;
L is a displaceable group selected from bromo, chloro, fluoro or iodo; and
R2 is selected from H, Ci-βalkyl, halogen, hydroxy, amino, Cι-6alkyl-amino, Cι-6alkyl- carbonyl, Cι-6alkyl-oxy and Ci-βalkyl-oxycarbonyl optionally substituted by one or more groups selected from halogen, amino and hydroxy;
comprising
A) heating a mixture of a compound of formula Va:
and an acetylating agent in the presence of a Lewis acid catalyst at a temperature and for a time effective to give compounds of formula Vb:
B) combining the compounds of formula Vb and a dicarbonyl compound to an alcohol solution at a temperature and for a time effective to give compounds of formula Vc:
C) heating the compound of formula Vc with a mixture of acids at a temperature and for a time effective to give compounds of formula I.
In another embodiment, R1 is, independently, H, C]-C6 alkyl, halogen, hydroxy 1, methoxy or cyano. In a more particular embodiment R1 is, independently, hydrogen or fluoro.
In another embodiment, L is a displaceable group. In another embodiment L is a displaceable group selected from bromo, chloro, fluoro or iodo. In a more particular embodiment L is bromo. In another embodiment, R2 is selected from H, C^a-kyl, halogen, hydroxy, amino or Cμδalkyl-oxy optionally substituted by one or more groups selected from halogen, amino and hydroxy. In a more particular embodiment, R2 is selected from H, Chalky-, Cι-6alkyl-oxy or hydroxy.
If necessary a number of different bases and solvents can be used for the above process. The above process may further include a step for separating, filtering or washing compounds that may be carried out in any number of ways known in the art.
In another embodiment, heating the compound of formula Va, the acetylating agent and the catalyst may be conducted at a temperature and for a time effective to provide compound Vb. In a more particular embodiment, the heating of formula Va, the acetylating agent and the catalyst may be conducted at a temperature between about 130 and about 135°C for about 1 to 2 hours.
In another embodiment, the acetylating agent are those functional derivatives of carboxylic acids that contain an acyl group and that can undergo nucleophilic substitution. For example, suitable acetylating agents include acetic acid, acetic anhydride, acetamide, acetyl chloride, acetyl bromide and ethyl acetate. In a more particular embodiment, the acetylating agent may be acetyl chloride.
In another embodiment, the Lewis acid catalyst may be selected from aluminum chloride, zirconium tetrachloride, bromide tetrachloride, HF and phosphoric acid. In a more particular embodiment, the Lewis acid catalyst may be selected from aluminum chloride or zirconium tetrachloride. In particular, the Lewis acid catalysts may be aluminum chloride.
In another embodiment the Lewis acid catalyst may be added in portions. In particular, the Lewis acid catalyst may be added in two portions.
In another embodiment, the pH level may be adjusted. In another embodiment, the pH level may be adjusted to about 7. In another embodiment, one of the carbonyl groups forming the dicarbonyl compound may be an ester. For example, suitable dicarbonyl compounds include Pyruvate or glyoxylate esters, methylglyoxal, and Cι-4oxalate. In particular, the dicarbonyl compound may be ethyl oxalate.
In another embodiment, reacting the compound of formula Vb with a dicarbonyl compound in an alcohol solution may be conducted at a temperature and for a time effective to provide compound Vc. In a more particular embodiment, the reaction may be conducted at a temperature between about 55 and about 60°C for a time between about 1 to 2 hours.
In another embodiment, the alcohol solution comprises sodium alkoxide in absolute alcohol. For example, suitable sodium alkoxides include sodium methoxide, sodium ethoxide sodium isopropoxide and sodium tert-butoxide. For example, suitable absolute alcohols include methanol, ethanol, propanol, butanol, isobutanol and tert-butanol. In particular, the alcohol solution comprises sodium ethoxide in absolute ethanol.
In another embodiment, reacting the compound of formula Vc with a mixture of acid may be conducted at a temperature and for a time effective to provide compound I. In a more particular embodiment, the reaction may be conducted at a temperature between about 70 and about 80°C for a time between about 1 to 2 hours.
In another embodiment, the mixture of acids may be a mixture of acetic and hydrochloric acid.
Minimizing the charge of aluminum chloride may help control any impurities that form during the above process.
Unless specified otherwise within this specification, the nomenclature used in this specification generally follows the examples and rules stated in Nomenclature of Organic Chemistry, Sections A, B, C, D, E, F, andH, Pergamon Press, Oxford, 1979, which is incorporated by references herein for its exemplary chemical structure names and rules on naming chemical structures.
The term "alkyl" used alone or as a suffix or prefix, refers to monovalent straight or branched chain hydrocarbon radicals comprising 1 to about 12 carbon atoms. Unless otherwise specified, "alkyl" generally includes both saturated alkyl and unsaturated alkyl.
The term "cycloalkyl," used alone or as suffix or prefix, refers to a monovalent ring- containing hydrocarbon radical comprising at least 3 up to about 12 carbon atoms.
The term "aryl" used alone or as suffix or prefix, refers to a hydrocarbon radical having one or more polyunsaturated carbon rings having aromatic character, (e.g., 4n + 2 delocalized electrons) and comprising 5 up to about 14 carbon atoms, wherein the radical is located on a carbon of the aromatic ring.
The term "heterocycle" used alone or as a suffix or prefix, refers to a ring-containing structure or molecule having one or more multivalent heteroatoms, independently selected from N, O, P and S, as a part of the ring structure and including at least 3 and up to about 20 atoms in the ring(s). Heterocycle may be saturated or unsaturated, containing one or more double bonds, and heterocycle may contain more than one ring. When a heterocycle contains more than one ring, the rings may be fused or unfused. Fused rings generally refer to at least two rings share two atoms therebetween. Heterocycle may have aromatic character or may not have aromatic character. The term "alkoxy" used alone or as a suffix or prefix, refers to radicals of the general formula -O-R, wherein -R is selected from a hydrocarbon radical. Exemplary alkoxy includes methoxy, ethoxy, propoxy, isopropoxy, butoxy, t-butoxy, isobutoxy, cyclopropylmethoxy, allyloxy, and propargyloxy. Halogen includes fluorine, chlorine, bromine and iodine. When a first group, structure, or atom is "directly connected" to a second group, structure or atom, at least one atom of the first group, structure or atom forms a chemical bond with at least one atom of the second group, structure or atom. "Saturated carbon" means a carbon atom in a structure, molecule or group wherein all the bonds connected to this carbon atom are single bond. In other words, there is no double or triple bonds connected to this carbon atom and this carbon atom generally adopts an sp3 atomic orbital hybridization. "Unsaturated carbon" means a carbon atom in a structure; molecule or group wherein at least one bond connected to this carbon atom is not a single bond. In other words, there is at least one double or triple bond connected to this carbon atom and this carbon atom generally adopts a sp or sp2 atomic orbital hybridization. The processes and synthetic methods described hereinthroughout may be carried out with or without a suitable solvent or base. Generally, suitable solvents are solvents which are substantially non-reactive with the starting materials (reactants), the intermediates, or products at the temperatures at which the reactions are carried out, i.e., temperatures which may range from the solvent's freezing temperature to the solvent's boiling temperature.
A given reaction may be carried out in one solvent or a mixture of more than one solvent. Depending on the particular reaction, suitable solvents for a particular work-up following the reaction may be selected. For example, suitable solvents may include water, alcohols, hydrocarbon solvents and halogenated derivatives. In particular, water, dichloromethane, xylene, ethanol and methanol.
Examples
Preparation ofl-(3-bromo-5-fluoro-2-hydroxyphenyl)ethanone A mixture of 2-bromo-4-fluorophenol (64.0 kg, 1.00 mol equiv) and acetyl chloride (62.5 kg, 2.39 mol equiv) was stirred and heated at 50-55°C for one hour. Excess acetyl chloride (10.8 kg) was removed by distillation and the residue was cooled to 25-30°C then diluted with dichloromethane (120 L). The mixture was further cooled to 10-15°C and aluminum chloride (51.0 kg, 1.15 mol equiv) was added in two portions. The temperature of the mixture was raised to 130-135°C over one hour during which time dichloromethane (80 L) was removed by distillation. The mixture was maintained at 130-135°C for one hour, diluted with xylene (250 L) and cooled to 10-15°C. The reaction mixture was added to a solution of 30% w/w hydrochloric acid (25 L) in water (500 L). The layers were separated and the organic phase was extracted with 10% w/w sodium hydroxide solution (300 L). The aqueous extract was cooled to 10-15°C and adjusted to pH 6.8-7.2 with 30% w/w hydrochloric acid (55.0 kg). The solid was filtered off, washed with water (60 L), then with petroleum ether (100 L) and dried at 55-60°C under vacuum. The yield of l-(3-bromo-5- fluoro-2-hydroxyphenyl)ethanone was 46.0 kg (60%).
Preparation of ethyl 8~bromo-6-fluoro-4-oxo-4H-chromene-2-carboxylate
A mixture of l-(3-bromo-5-fluoro-2-hydroxyphenyl)ethanone (46.0 kg, 1.00 mol equiv) and diethyl oxalate (172.0 kg, 6.00 mol equiv) was added to a solution of sodium ethoxide (66.8 kg, 4.9 mol equiv) in absolute ethanol (250 L) at 60°C. The mixture was stirred at 55-60°C for one hour and ethanol was removed by distillation. The residual mixture was diluted with water (300 L) and the precipitated solid isolated by filtration. This solid was heated with a mixture of acetic acid (210 L) and 30 w/w hydrochloric acid (55.5 L) at 70- 80°C for two hours. After cooling at 25°C, the mixture was diluted with water (150 L and 100 L), then with 12% w/w sodium bicarbonate solution (50 L) and finally methanol (100 L) before drying at 70°C under vacuum. The yield of ethyl 8-bromo-6-fluoro-4-oxo-4H- chromene-2-carboxylate was 38.6 kg (63%).

Claims

1. A process of preparing a compound of formula I:
wherein R1 is selected from H, Ci-^alkyl, halogen, amino, Cι-6alkyl-oxy, or hydroxy; L is a displaceable group selected from bromo, chloro, fluoro or iodo; and R2 is selected from H, Ci-βalkyl, halogen, hydroxy, amino, Cι-6alkyl-amino, Cι-6alkyl- carbonyl, Cι-6alkyl-oxy and Ci-6alkyl-oxycarbonyl optionally substituted by one or more groups selected from halogen, amino and hydroxy; comprising:
A) heating a mixture of a compound of formula Va:
and acetylating agent in the presence of a Lewis acid catalyst at a temperature and for a time effective to give compounds of formula Vb: Vb,
B) combining the compounds of formula Vb and a dicarbonyl compound to an alcohol solution at a temperature and for a time effective to give compounds of formula Vc:
C) heating the compound of formula Vc with a mixture of acids at a temperature and for a time effective to give compounds of formula I.
2. A process according to claim 1, wherein R1 is, independently, hydrogen or fluoro.
3. A process according to claim 1, wherein R2 is, independently, H, Ci-βalkyl, Cι-6alkyl- oxy or hydroxy.
4. A process according to claim 1, wherein L is bromo.
5. A process of preparing a compound of formula I:
wherein R1 is selected from H, d-inaU y-, halogen, amino, Cι-6alkyl-oxy, or hydroxy; L is a displaceable group selected from bromo, chloro, fluoro or iodo; and R2 is selected from H, halogen, hydroxy, amino, Cι-6alkyl-amino, Cι-6alkyl- carbonyl, Cι-6alkyl-oxy and Cι-6alkyl-oxycarbonyl optionally substituted by one or more groups selected from halogen, amino and hydroxy;
comprising:
A) heating a mixture of a compound of formula Va:
and acetyl chloride in the presence of either aluminum chloride or zirconium tetrachloride at a temperature and for a time effective to give compounds of formula Vb:
B) combining the compounds of formula Vb and diethyl oxalate to a solution of sodium ethoxide in absolute ethanol at a temperature and for a time effective to give compounds of formula Vc:
C) heating the compound of formula Vc with a mixture of acetic acid and hydrochloric acid at a temperature and for a time effective to give compounds of formula I.
6. A process according to claim 5, wherein R1 is, independently, hydrogen or fluoro.
7. A process according to claim 5, wherein R is, independently, H, Cι-6alkyl, Cι-6alkyl- oxy or hydroxy.
8. A process according to claim 5, wherein L is bromo.
EP05722256A 2004-03-25 2005-03-22 Novel process Withdrawn EP1732914A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0400786A SE0400786D0 (en) 2004-03-25 2004-03-25 Novel Process for the preparation of a chromone intermediate
PCT/SE2005/000415 WO2005092879A1 (en) 2004-03-25 2005-03-22 Novel process

Publications (1)

Publication Number Publication Date
EP1732914A1 true EP1732914A1 (en) 2006-12-20

Family

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Country Status (13)

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EP (1) EP1732914A1 (en)
JP (1) JP2007530535A (en)
KR (1) KR20060129496A (en)
CN (1) CN1953970A (en)
AU (1) AU2005226605A1 (en)
BR (1) BRPI0509020A (en)
CA (1) CA2561160A1 (en)
IL (1) IL177963A0 (en)
NO (1) NO20064862L (en)
RU (1) RU2006135484A (en)
SE (1) SE0400786D0 (en)
WO (1) WO2005092879A1 (en)
ZA (1) ZA200607553B (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05255172A (en) * 1992-03-16 1993-10-05 Shell Internatl Res Maatschappij Bv Manufacture of 3,6-dichloro-2-hydroxyacetophenone
ATE169924T1 (en) * 1993-05-18 1998-09-15 Takeda Chemical Industries Ltd BENZOPYRAN DERIVATIVES AND THEIR USE
JPH07291983A (en) * 1993-05-18 1995-11-07 Takeda Chem Ind Ltd Benzopyran derivative and medicine containing the same
WO2001094335A2 (en) * 2000-06-02 2001-12-13 Eli Lilly & Company Methods for producing chiral chromones, chromanes, amino substituted chromanes and intermediates therefor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2005092879A1 *

Also Published As

Publication number Publication date
WO2005092879A8 (en) 2006-10-19
CN1953970A (en) 2007-04-25
RU2006135484A (en) 2008-05-10
CA2561160A1 (en) 2005-10-06
SE0400786D0 (en) 2004-03-25
JP2007530535A (en) 2007-11-01
BRPI0509020A (en) 2007-08-07
WO2005092879A1 (en) 2005-10-06
NO20064862L (en) 2006-12-21
ZA200607553B (en) 2008-09-25
KR20060129496A (en) 2006-12-15
IL177963A0 (en) 2006-12-31
AU2005226605A1 (en) 2005-10-06

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