EP1683579A1 - Disposable device for the continuous separation by centrifugation of a physiological liquid - Google Patents

Disposable device for the continuous separation by centrifugation of a physiological liquid Download PDF

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Publication number
EP1683579A1
EP1683579A1 EP05405038A EP05405038A EP1683579A1 EP 1683579 A1 EP1683579 A1 EP 1683579A1 EP 05405038 A EP05405038 A EP 05405038A EP 05405038 A EP05405038 A EP 05405038A EP 1683579 A1 EP1683579 A1 EP 1683579A1
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EP
European Patent Office
Prior art keywords
enclosure
tubular
chamber
fixed axial
output
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05405038A
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German (de)
French (fr)
Inventor
Jean-Denis Rochat
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Jean-Denis Rochat
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Application filed by Jean-Denis Rochat filed Critical Jean-Denis Rochat
Priority to EP05405038A priority Critical patent/EP1683579A1/en
Publication of EP1683579A1 publication Critical patent/EP1683579A1/en
Withdrawn legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B5/00Other centrifuges
    • B04B5/04Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B11/00Feeding, charging, or discharging bowls
    • B04B11/08Skimmers or scrapers for discharging ; Regulating thereof
    • B04B11/082Skimmers for discharging liquid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B5/00Other centrifuges
    • B04B5/10Centrifuges combined with other apparatus, e.g. electrostatic separators; Sets or systems of several centrifuges
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B7/00Elements of centrifuges
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B9/00Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls
    • B04B9/12Suspending rotary bowls ; Bearings; Packings for bearings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B5/00Other centrifuges
    • B04B5/04Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0478Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with filters in the separation chamber
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B7/00Elements of centrifuges
    • B04B2007/005Retaining arms for gripping the stationary part of a centrifuge bowl or hold the bowl itself

Abstract

The device has an elongated tubular centrifugal enclosure (1), and an axial fixed unit (4) including an output passage (9) whose intake zone is arranged closer to an end of the enclosure and in a concentration zone of low density constituents. An outlet passage (8) has an intake opening arranged closer to the end of the enclosure and in a concentration zone of high density constituents.

Description

  • The present invention relates to a disposable device for the continuous separation by centrifugation of a physiological liquid, in particular blood, comprising a fixed axial input and output element around the axis of which a plastic centrifuge chamber. is rotatably mounted, an inlet channel for the centrifugal blood passing longitudinally through said axial inlet and outlet element and the dispensing opening of which is located near the bottom of said centrifuge chamber, an outlet passage for at least one separate component, the inlet opening of which is close to the end of said enclosure opposite said bottom and in a zone of concentration of at least one of the separated constituents having the lowest specific mass for the continuously withdrawing, this passage passing through a longitudinal portion of said fixed axial input and output element, a rotary joint between said element fixed axial and said centrifuge chamber.
  • The known cups or separation bowls of this type are intended for semi-continuous separation, which consists in progressively evacuating the plasma separated from the red blood cells and storing the red blood cells. The reason why the red blood cells are not removed from the separation chamber as they separate, as the plasma is due to the fact that the tangential force applied to them is relatively high and the deceleration that it would suffer during the abrupt passage in a fixed evacuation conduit would cause a high rate of hemolysis.
  • Such cups are described in numerous patents, among which we can mention US 4,300,717 where they appeared for the first time.
  • To overcome the drawbacks of this type of bowl has been proposed a bowl system having a flexible tube for the supply and removal of separated components of the blood.
  • The system used to cancel the effect of rotation of the centrifuge chamber on the attachment of the flexible conduit to this chamber, in the centrifugal separators of this type, is disclosed in US 3,586,413. It allows, by forming an open loop whose one end is integral in rotation with the axis of the centrifuge bowl rotating at the speed 2ω, while its other end, coaxial with the first, is fixed while the open loop is driven at the speed ω, generating a rotation of the flexible tube rotating about its own axis at the speed -ω and thus cancel any torsion of the flexible tube
  • This principle, which makes it possible to eliminate any joint between the flexible tube and the rotating member has been widely adopted in a large number of centrifugal devices working with continuous flow. In fact, unlike centrifuges with fixed feed and discharge tubes, the separated components do not undergo a sudden deceleration of their tangential speed, so that the risks of haemolysis are reduced.
  • However, given the speed of the rotating member in a centrifuge, the flexible tube rotating on itself at the speed -ω is subjected to a tensile stress generated by the centrifugal force, to a bending stress due to the rotation on itself of the portion of the tube forming the open loop at the speed -ω, and a heating generated by the work of the viscous forces in the material due to the aforementioned bending. In the In case of blood centrifugation, the temperature should not be> 40 ° C.
  • Therefore the rotational speed of the centrifuge bowl is limited, so that the diameter of this bowl can not be too small or it could affect the quality of the separation. In addition, the drive mechanism of the bowl and the flexible tube is relatively complex and expensive.
  • It can therefore be seen that the existing solutions do not make it possible satisfactorily to meet the demand for a simple, small, easy-to-use separator, working with inexpensive disposable centrifugal enclosures, in which the blood to be treated stays minimum time and able to work with a good flow.
  • This is why it has appeared necessary to reconsider the concept of the separation device in order to be able to respond more satisfactorily to the aforementioned requirements.
  • The object of the present invention is to overcome, at least in part, the aforementioned drawbacks.
  • To this end, the present invention relates to a disposable device for the continuous separation by centrifugation of a physiological liquid, in particular blood according to claim 1.
  • The main advantage of this disposable device is its low volume and the fact of allowing a continuous separation with fixed supply and discharge ducts. The small volume makes it possible to reduce the cost of the disposable device and consequently also the volume of the centrifugal separator. A small volume centrifuge chamber makes it possible to reduce the time during which the liquid to be separated is subjected to separation forces, and thus to reduce the rate of hemolysis and platelet activation.
  • Advantageously, the tubular centrifugal receptacle has a cylindrical tightening at its upper end to engage with guide rollers and in which a rotating seal is housed between the fixed axial element and the receptacle to ensure the sterility of the liquid. centrifugation course.
  • The small diameter of the cylindrical tightening makes it possible to reduce the tolerance of this diameter by reducing the amount of shrinkage of the plastic, the importance of which is proportional to the size of the piece. The fact that the rotary joint also works on a part of small diameter reduces the heating. In addition, the precision of the guidance of the centrifugation device makes it possible to use the seal only for sealing and not to compensate for the decentering defects of the rotating centrifuge chamber relative to the fixed axial input element. and output. Therefore, the preload to which the seal must be subjected can be reduced to a minimum, that is to say that it is only a function of the only conditions necessary for sealing and therefore no longer constitutes an hybrid, which also reduces heating.
  • Other features and advantages of the present invention will appear in the light of the following description and with the aid of the accompanying drawings which illustrate, schematically and by way of example, two embodiments of the disposable device for the continuous separation by centrifugation.
  • Figure 1 is a front elevational view of a centrifugal separator for using the device object of the present invention;
  • Figure 2 is a partial perspective view of Figure 1;
  • Figure 3 is a top view of Figure 2;
  • Figure 4 is a partial view in axial section on a larger scale of the first embodiment of the disposable centrifuge device;
  • Figure 5 is a view similar to Figure 4 of a second embodiment of this device.
  • The housing of the centrifugal separator intended to use the device according to the present invention and illustrated schematically in FIG. 1 comprises two elongate centrifugation enclosures 1, 2 of tubular form. The first centrifugal tubular chamber 1 comprises a supply duct 3 which is connected to a fixed axial input and output element 4 of the centrifuge chamber 1. This supply duct 3 is connected to a pumping device 5 which comprises two pumps 6 and 7 phase-shifted by 180 ° relative to each other to ensure a continuous flow of a physiological fluid, especially blood. An air detector 10 is arranged along the supply duct 3.
  • Two outlet ducts 8, 9 are connected to the fixed axial element 4, to allow the continuous output of two components of different densities of the physiological fluid. In the case of blood, the outlet duct 8 is intended for the outlet of the RBC concentrated red blood cells and the duct 9 for the outlet of the platelet rich PRP plasma. This outlet duct 9 comprises a valve 11 and divides into two branches 9a, 9b. The branch 9a is used to recover the platelet concentrate and is controlled by a valve 12. The valves 11 and 12 operate in exclusive OR logic either to pass the PRP from the chamber 1 to the chamber 2, or to empty the platelet concentrate from enclosure 2 to exit 9a. The branch 9b serves to drive the PRP to a pumping device 13 comprising two pumps 14 and 15 out of phase by 180 ° and serving to ensure the continuous supply of the second centrifugal tubular chamber 2 by a supply duct Connected to a fixed axial element 17 of the second centrifugal tubular enclosure 2. An outlet conduit 24 for the platelet-poor plasma PPP is also connected to the fixed axial element 17.
  • FIG. 2 represents the driving and guiding mode of the centrifugal tubular enclosure 1. The set of driving and guiding elements of the centrifugal tubular enclosure is located on the same support 18 connected to the housing of the centrifuge chamber. centrifugal separator by an anti-vibration suspension 19 of silentbloc type. The support 18 has a vertical wall whose lower end terminates in a horizontal support arm 18a to which is attached a drive motor 20. The drive shaft 20a of this motor 20 has a polygonal shape, such as a Torx® profile, complementary to an axial recess formed in a small tubular element 1a which projects under the bottom of the centrifugal tubular enclosure 1. The coupling between the motor drive shaft 20 and the element tubular 1a must be made with very high precision, to ensure extremely precise guidance of this end of the tubular centrifuge chamber 1.
  • The upper end of the tubular centrifuge chamber 1 comprises a cylindrical axial guide member 1b of diameter substantially smaller than that of the tubular centrifuge chamber 1, which protrudes on its upper face. The cylindrical face of this element 1b is intended to engage with three centering rollers 21 that can be seen in particular in FIG. 3. One of these rollers 21 is integral with an arm 22, one end of which is pivotally mounted on an upper horizontal portion 18b of the support 18. This arm 22 is subjected to the force of a spring (not shown) or any other suitable means for communicating a torque tending to rotate in the direction of the watch, with reference to FIG. 3, so that it bears resiliently against the cylindrical surface of the cylindrical axial guide member 1b, so that the tubular centrifuge chamber can be placing and removing the support 18 by pivoting the arm 22 in the opposite direction to that of the needles of the watch. A device for locking the angular position of the arm 22 corresponding to that in which its roller 21 bears against the cylindrical surface of the cylindrical axial guide member 1b is provided, to avoid having a too strong preload of the spring associated with the arm 22.
  • The span between the cylindrical axial guide element 1b and the upper end of the tubular enclosure 1 serves, in cooperation with the centering rollers 21, axial abutment, preventing disengagement between the drive shaft of the motor 20 and the axial recess of the tubular element 1a protruding under the bottom of the tubular enclosure 1.
  • Advantageously, one could also slightly incline the axes of rotation of the guide rollers 21 by a few angular degrees, <2 °, in respective planes tangent to a circle coaxial with the axis of rotation of the tubular centrifuge chamber 1, passing by the respective axes of rotation of the three rollers, in a selected direction, according to the direction of rotation of the rollers, in which they induce on the tubular enclosure 1 a force directed downwards.
  • An elastic element for centering and fixing 23 of the fixed axial input and output element 4 of the tubular centrifugation enclosure is integral with the upper horizontal portion 18b of the support 18. This element 23 comprises two symmetrical elastic branches, of semicircular shapes and which each end with an outwardly curved portion, intended to transmit to these elastic branches forces to separate them from one another, during the lateral introduction of the fixed axial element 4 input and output between them.
  • As can be seen, all the positioning and guiding elements of the fixed and rotating parts of the centrifugal tubular enclosure 1 are integral with the support 18, so that the accuracy is a function of the accuracy of the support 18 itself, which can be manufactured with very low tolerances, especially since it is not a complicated piece to manufacture. Other factors that contribute to ensuring high accuracy are the relatively large axial distance, due to the elongate tubular shape of the centrifuge enclosure, between the lower guide and the upper guide. Finally, the fact of working on a cylindrical guide surface 1b of small diameter makes it possible to reduce, on the one hand, the errors due to the withdrawal of the injected plastic material in which the centrifuge chambers 1, 2 are manufactured, the shrinkage being proportional to the dimension, contrary to what one has in the case of a machined part and on the other hand the errors of evil round.
  • This accuracy of the guidance of the tubular centrifugation chamber makes it possible to form flows of very small thickness on the side wall of this centrifuge chamber. This, therefore, allows for a small volume of liquid staying in the chamber, which is a factor capable of reducing the risk of hemolysis and the risk of platelet activation, this risk being certainly a function of the forces applied, but also the time during which blood components are subjected to these forces. Thus, we can not set a force threshold, since for a given force, the risk of hemolysis can be practically nil for a certain duration, whereas it can be much more important with the same force. but for a significantly longer period.
  • Preferably, the centrifugal tubular enclosures will have a diameter of between 10 and 40 mm, preferably 22 mm, and will be driven at a speed of rotation of between 5,000 and 100,000 rpm, so that the tangential speed at which the liquid is submitted does not exceed 26 m / s. The axial length of the tubular centrifugation chamber is advantageously between 40 and 200 mm, preferably 80 mm. Such parameters make it possible to ensure a liquid flow rate of between 20 and 400 ml / min (especially for dialysis), preferably 60 ml / min, corresponding to a residence time of the liquid of 5 to 60 seconds, preferably 15 to 60 seconds. s in the tubular enclosure.
  • We will now examine in more detail the design of the tubular centrifuge chamber 1 intended to be associated with the centrifugal separator which has just been described. It may be specified here that all that has been explained in the foregoing description, as regards the dimensions, the drive, the positioning and the guidance of the centrifugal tubular enclosure 1 also applies to the tubular enclosure However, the latter having only one output 24 for the PPP, is internally simpler than the design of the tubular enclosure 1.
  • As illustrated in FIG. 4, the tubular enclosure 1 is made from two parts which terminate in respective annular flanges 1c, 1d welded to each other. The internal space of the enclosure is delimited by the substantially cylindrical wall of this enclosure. The axial fixed input and output element 4 enters this tubular enclosure 1 through an axial opening formed through the cylindrical axial guide element 1b. The tightness between this axial opening integral with the chamber driven in rotation and the fixed axial element 4 is achieved by a tubular joint 25, one segment of which is fixed on a cylindrical portion of this fixed axial input and output element 4, while another segment is introduced into an annular space 26 of the cylindrical axial guide element 1b and is supported on a convex surface of the tubular wall 27 separating the axial opening through the cylindrical axial guide member 1b of the annular space 26. This seal serves to preserve the sterility of the liquid contained in the centrifuge chamber. As illustrated in this Figure 4, the portion of the tubular seal 25 which bears on the tubular wall 27 undergoes a slight radial deformation to ensure sealing.
  • It can be seen that the diameter on which the tubular seal 25 rubs is small and is preferably <10 mm, so that the heating is limited to acceptable values. It can be seen from the aforementioned possible dimensions given for the centrifugal tubular enclosure, that the axial distance between the upper and lower centering and guiding means of this enclosure is greater than five times the diameter of the cylindrical element. axial guide 1b. Given the accuracy with which the tubular enclosure 1 is guided and the accuracy that can reach the relative positioning of the fixed axial input and output element 4, the seal has practically no need to compensate for a lack of concentricity. of the tubular enclosure 1 in rotation, as is the case of the aforementioned devices of the state of the art working in semi-continuous flow. This also contributes to reducing the heating of the rotating tubular joint 25 and thus makes it possible to increase the speed of rotation of the centrifugal tubular enclosure.
  • The axial input and output fixed element 4 comprises a tubular portion 3a which extends the supply duct 3 connected to this axial fixed element 4 to close proximity from the bottom of the tubular centrifuge chamber 1 to bring blood or other physiological fluid to separate.
  • The outlet ducts 8 and 9 connected to the fixed axial inlet and outlet element 4 each comprise an axial segment 8a, respectively 9a which penetrates into the tubular enclosure and opens into the part of the fixed axial element 4d. inlet and outlet which is in the vicinity of the upper end of the tubular centrifuge chamber 1. The inlet end of each of these outlet ducts 8a, 9a is formed by a circular slot. Each of these slots is formed between two disks 28, 29, respectively 30, 31, integral with the fixed axial element 4 input and output.
  • In this example, the radial distance between the edges of the discs 28, 29 and the side wall of the chamber 1 is less than the radial distance between the edges of the discs 30, 31 and the same side wall. By this arrangement, the PRP-rich platelet-rich plasma of lower density than the RBC red blood cells is sucked by the pumping device 13 (FIG 1) into the outlet duct 9, while the red blood cells are aspirated by the gradient of pressure generated by the centrifugal force within the liquid, in the outlet duct 8.
  • As can be seen, the diameter of the portion of the tubular centrifuge chamber 1 located in the exit zone of the PRP and the RBC where the discs 28 to 31 are located is slightly larger than that of the remainder of this tubular enclosure. 1, so as to increase the respective thicknesses of the PRP and RBC layers to facilitate their separate exits.
  • A dead space is formed between adjacent disks 29 and 30. Its role is to trap leukocytes, whose density is between that of RBCs and platelets, but which is much larger than RBCs and platelets. The disc 30 has a filter 30a to allow the leukocytes to be separated from the plasma and to trap in the dead space between the discs 29 and 30 only the leucocytes.
  • The second embodiment of the tubular centrifuge chamber illustrated in FIG. 5 differs from that of FIG. 4 essentially in the presence of a dam 32. The latter has an annular shape, comprising a cylindrical portion 32a located in front of the circular inlet opening of the PRP formed between the discs 30 and 31. The diameter of this cylindrical part 32a is chosen to be situated in the space separating the edges of the discs 28, 29 of the side wall of the disc. enclosure 1 substantially corresponding to the diameter of the interface between the layers formed by the RBC and the PRP. The two ends of this cylindrical portion 32a end with flat rings, 32b, 32c. The plane ring 32b extends outside the cylindrical portion 32a, while the flat ring 32c extends within this cylindrical portion 32a. The outer plane ring 32b is housed in a clearance of the annular flange 1d and is clamped between the two annular flanges 1c and 1d. This outer plane ring 32b is still traversed by a plurality of openings 32d to allow the passage of the RBCs.
  • This dam 32 has three roles to play. One is to create a physical barrier between the circular inlet opening of the PRP located between the discs 30 and 31 and the RBCs, so as to prevent the swirls generated by the suction at the opening of the opening. admission is likely to re-mix RBCs and PRP. A second role is to collect RBCs on the same diameter as the plasma, which reduces hemolysis because the edges of the disks 30, 31 forming the exit aperture of the RBC dipping less deeply in the RBC layer, since all the discs 28 to 31 are of the same diameter. Finally, the third role is to at least partially retain the leucocytes inside the cylindrical portion 32a of the dam 32.
  • The remainder of this tubular centrifuge chamber 1 according to this second embodiment is substantially similar to the first embodiment which has just been described. A leucocyte filter similar to the filter 29a of Figure 4 may also be provided to trap leukocytes between the disks 29 and 30.

Claims (6)

  1. Disposable device for the continuous separation by centrifugation of a physiological fluid, in particular blood, comprising a fixed axial input and output element (4) around the axis of which a plastic centrifuge chamber (1) is mounted in rotation, an inlet channel (3) for the centrifugal blood passing longitudinally through said axial input and output element (4) and whose distribution opening is located near the bottom of said centrifuge chamber ( 1), an outlet passage (9) for at least one separate component, the inlet opening of which is located near the end of said enclosure (1) opposite said bottom and in a concentration zone of at least one minus one of the separate components having the lowest specific mass to continuously remove it, this passage (9) passing through a longitudinal portion of said fixed axial (4) input and output member, a rotary joint ((25) between said element fixed axial shaft (4) and said centrifuge chamber (1), characterized in that said centrifuge chamber (1) is of elongate tubular shape, said fixed axial input and output element (4) having a second outlet passage (8) for at least one second of the separated constituents, the intake opening of which is close to the end of said enclosure (1) opposite said bottom and in a concentration zone of said second separate constituent having the specific gravity the highest to remove it continuously.
  2. Device according to claim 1, wherein the end of said centrifugal tubular enclosure (1) opposite its bottom comprises a cylindrical constriction (1b) through which said fixed axial element (4) passes and in which said rotary joint (25) ) is arranged.
  3. Device according to claim 2, wherein the outer surface of said cylindrical constriction (1b) is intended to engage with first guide means (21) of said enclosure (1), the bottom of said tubular centrifuge enclosure having means (1a) for engaging with second means for guiding, supporting and driving this chamber (1).
  4. The device of claim 1, wherein a leukocyte trap (32) is disposed between the inlet openings of said first and second outlet passages (8, 9) and a filter element (32a) connects said trap (32). ) said outlet passage (9), the inlet opening of which is close to the end of said receptacle opposite its bottom and at a radial distance from the side wall of said receptacle corresponding to the concentration zone of at least one of the separate components having the lowest specific mass.
  5. Device according to one of the preceding claims, in which the said fixed outlet duct (9), the inlet opening of which is in the concentration zone of at least one of the separate constituents having the lowest density, is connected to a second chamber (2) centrifugation.
  6. Device according to claim 1, wherein the inlet openings of said outlet passages (8, 9) are two circular openings of the same diameter, an annular barrier (32) being located in front of the circular inlet opening of the phase of said liquid having the lowest density, the diameter of said dam (32) being in the space between the circular inlet opening of said first passage (9) of the side wall of the chamber 1, corresponding substantially to the diameter of the interface between the layers formed by the RBCs and the PRP.
EP05405038A 2005-01-25 2005-01-25 Disposable device for the continuous separation by centrifugation of a physiological liquid Withdrawn EP1683579A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05405038A EP1683579A1 (en) 2005-01-25 2005-01-25 Disposable device for the continuous separation by centrifugation of a physiological liquid

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
EP05405038A EP1683579A1 (en) 2005-01-25 2005-01-25 Disposable device for the continuous separation by centrifugation of a physiological liquid
US11/814,587 US8070664B2 (en) 2005-01-25 2006-01-23 Disposable device for the continuous centrifugal separation of a physiological fluid
AU2006208525A AU2006208525A1 (en) 2005-01-25 2006-01-23 Disposable device for the continuous centrifugal separation of a physiological fluid
EP20060700529 EP1871530B1 (en) 2005-01-25 2006-01-23 Disposable device for for the continuous separation by centrifugation of a physiological liquid
CA 2592275 CA2592275A1 (en) 2005-01-25 2006-01-23 Disposable device for the continuous centrifugal separation of a physiological fluid
JP2007551529A JP2008528066A (en) 2005-01-25 2006-01-23 Disposable device for continuous separation of physiological fluids by centrifugation
DE200660016762 DE602006016762D1 (en) 2005-01-25 2006-01-23 Disposable device for the continuous separation of a physiological liquid by centrifugation
AT06700529T AT480333T (en) 2005-01-25 2006-01-23 Disposable device for the continuous separation of a physiological liquid by centrifugation
PCT/CH2006/000049 WO2006079238A1 (en) 2005-01-25 2006-01-23 Disposable device for the continuous centrifugal separation of a physiological fluid
US13/287,551 US8348823B2 (en) 2005-01-25 2011-11-02 Disposable device for the continuous centrifugal separation of a physiological fluid

Publications (1)

Publication Number Publication Date
EP1683579A1 true EP1683579A1 (en) 2006-07-26

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EP05405038A Withdrawn EP1683579A1 (en) 2005-01-25 2005-01-25 Disposable device for the continuous separation by centrifugation of a physiological liquid
EP20060700529 Active EP1871530B1 (en) 2005-01-25 2006-01-23 Disposable device for for the continuous separation by centrifugation of a physiological liquid

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP20060700529 Active EP1871530B1 (en) 2005-01-25 2006-01-23 Disposable device for for the continuous separation by centrifugation of a physiological liquid

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US (2) US8070664B2 (en)
EP (2) EP1683579A1 (en)
JP (1) JP2008528066A (en)
AT (1) AT480333T (en)
AU (1) AU2006208525A1 (en)
CA (1) CA2592275A1 (en)
DE (1) DE602006016762D1 (en)
WO (1) WO2006079238A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1683579A1 (en) 2005-01-25 2006-07-26 Jean-Denis Rochat Disposable device for the continuous separation by centrifugation of a physiological liquid
EP1911520A1 (en) * 2006-10-10 2008-04-16 Jean-Denis Rochat Disposable set for separating blood or for washing blood components
US9222067B2 (en) * 2008-04-22 2015-12-29 Pneumatic Scale Corporation Single use centrifuge system for highly concentrated and/or turbid feeds
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
US9339025B2 (en) 2010-08-25 2016-05-17 New Health Sciences, Inc. Method for enhancing red blood cell quality and survival during storage
CA2817106C (en) 2010-11-05 2020-08-25 Paul Vernucci Irradiation of red blood cells and anaerobic storage
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
EP2694217B1 (en) 2011-04-08 2018-07-18 Sorin Group Italia S.r.l. Disposable device for centrifugal blood separation
WO2013023156A1 (en) * 2011-08-10 2013-02-14 New Health Sciences, Inc. Integrated leukocyte, oxygen and/or co2 depletion, and plasma separation filter device
US9327296B2 (en) 2012-01-27 2016-05-03 Fenwal, Inc. Fluid separation chambers for fluid processing systems
CA2868862C (en) 2012-09-25 2017-06-27 Stem Cell Partners Llc Method and apparatus for preparing single donor thrombin serum
WO2014134503A1 (en) 2013-02-28 2014-09-04 New Health Sciences, Inc. Gas depletion and gas addition devices for blood treatment
US10039876B2 (en) 2014-04-30 2018-08-07 Sorin Group Italia S.R.L. System for removing undesirable elements from blood using a first wash step and a second wash step
CN106457263B (en) * 2014-06-04 2019-07-16 生物安全股份有限公司 Multiprocessing and isolated system for biofluid
CN207188020U (en) * 2014-09-25 2018-04-06 Fl史密斯公司 Centrifugal seal part and sealing device and the centrifuge for accommodating it
MX2017011595A (en) 2015-03-10 2018-06-15 New Health Sciences Inc Oxygen reduction disposable kits, devices and methods of use thereof.
EP3285711A4 (en) 2015-04-23 2018-11-07 New Health Sciences, Inc. Anaerobic blood storage containers
SG11201708234XA (en) * 2015-05-07 2017-11-29 Biosafe Sa A device, system and method for the continuous processing and separation of biological fluids into components
US10207044B2 (en) 2015-07-29 2019-02-19 Fenwal, Inc. Five-port blood separation chamber and methods of using the same
CN109195632A (en) 2016-05-27 2019-01-11 新健康科学股份有限公司 Anaerobism blood storage and pathogen method for deactivating

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2963219A (en) * 1956-04-26 1960-12-06 Separator Ab System for continuous operation of series connected hermetically closed centrifugal separators
JPS56166957A (en) * 1980-05-26 1981-12-22 Asahi Chem Ind Co Ltd Apparatus for communicating fluid
EP0297216A1 (en) * 1987-04-08 1989-01-04 DIDECO S.p.A. Centrifugation bowl for the continuous centrifugation of blood
JPH09192215A (en) * 1996-01-17 1997-07-29 Takaharu Nakane Centrifugal bowl
US5851169A (en) * 1996-01-31 1998-12-22 Medtronic Electromedics, Inc. Rotary plate and bowl clamp for blood centrifuge
DE19822191C1 (en) * 1998-05-16 1999-08-19 Braunschweigische Masch Bau Discontinuous centrifuge with a cleaning out system
EP1057534A1 (en) * 1999-06-03 2000-12-06 Haemonetics Corporation Centrifugation bowl with filter core

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3317127A (en) * 1945-03-02 1967-05-02 Little Inc A Centrifuge
US2536793A (en) * 1945-03-02 1951-01-02 Separator Ab Sealing device for centrifugal separators
US3073517A (en) * 1959-04-07 1963-01-15 Beckman Instruments Inc Continuous flow centrifuge apparatus and rotor therefor
US3401876A (en) * 1966-07-25 1968-09-17 Dade Reagents Inc Mixing and decanting centrifuge
US3409213A (en) * 1967-01-23 1968-11-05 500 Inc Rotary seal and centrifuge incorporation
US3565330A (en) * 1968-07-11 1971-02-23 Cryogenic Technology Inc Rotary seal and centrifuge incorporating same
US3706412A (en) * 1971-07-28 1972-12-19 Haemonetics Corp Pressure-actuated centrifuge chuck and centrifuge incorporating the same
US3785549A (en) * 1972-07-31 1974-01-15 Haemonetics Corp Centrifuge chuck for disposable, snap-in centrifuge rotor
US4140268A (en) * 1977-03-15 1979-02-20 Haemo-Transfer S.A. Centrifugating device for biological liquids, having a rotatable container, and supporting bracket therefor
DE2749367A1 (en) * 1977-11-04 1979-05-10 Peter R Dr Med Lorenz Gripper bracket for the filling device for zonal rotors
US4300717A (en) * 1979-04-02 1981-11-17 Haemonetics Corporation Rotary centrifuge seal
JPS644820B2 (en) * 1982-10-13 1989-01-26 Nikkiso Co Ltd
US4684361A (en) * 1985-10-11 1987-08-04 Cardiovascular Systems, Inc. Centrifuge
US4692136A (en) * 1985-10-11 1987-09-08 Cardiovascular Systems Inc. Centrifuge
US4983158A (en) * 1986-07-22 1991-01-08 Haemonetics Corporation Plasmapheresis centrifuge bowl
US4943273A (en) * 1986-07-22 1990-07-24 Haemonetics Corporation Disposable centrifuge bowl for blood processing
US4767396A (en) * 1987-03-03 1988-08-30 Haemonetics Corporation Method and apparatus for processing biological fluids
IT1203461B (en) * 1987-04-08 1989-02-15 Dideco Spa Cell for blood centrifugation
US5100372A (en) * 1990-03-02 1992-03-31 Haemonetics Corporation Core for blood processing apparatus
US5045048A (en) * 1990-03-29 1991-09-03 Haemonetics Corporation Rotary centrifuge bowl and seal for blood processing
US5141486B1 (en) * 1990-11-05 1996-01-30 Cobe Lab Washing cells
DE69310995T2 (en) * 1992-04-29 1997-09-04 Cobe Lab Centrifuge with a single swing arm to hold a stator tube
WO1994008721A1 (en) * 1992-10-13 1994-04-28 Haemonetics Corporation Disposable centrifuge rotor and core
CH687505A5 (en) * 1993-01-29 1996-12-31 Elp Rochat Centrifugal separator for fluids.
US5505683A (en) * 1993-12-10 1996-04-09 Haemonetics Corporation Centrifuge bowl gripping apparatus having a retaining arm with a stationary jaw and a moveable jaw
US5514070A (en) * 1994-01-21 1996-05-07 Haemonetics Corporation Plural collector centrifuge bowl for blood processing
JP3313572B2 (en) * 1996-04-03 2002-08-12 ヘモネティクス・コーポレーション Blood processing centrifuge bowl
AT186235T (en) * 1996-04-24 1999-11-15 Claude Fell Cell separation device for biological liquids like blood
US5919125A (en) * 1997-07-11 1999-07-06 Cobe Laboratories, Inc. Centrifuge bowl for autologous blood salvage
US6629919B2 (en) * 1999-06-03 2003-10-07 Haemonetics Corporation Core for blood processing apparatus
JP2001276663A (en) * 2000-03-30 2001-10-09 Haemonetics Corp Centrifugal separating bowl for particle separation
ITMI20010899A1 (en) * 2001-04-30 2002-10-30 Dideco Spa of the washing phase control system in a cell for the centrifugation of blood
US7186230B2 (en) * 2002-03-04 2007-03-06 Therakos, Inc Method and apparatus for the continuous separation of biological fluids into components
US7211037B2 (en) * 2002-03-04 2007-05-01 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
JP4304031B2 (en) * 2003-09-11 2009-07-29 テルモ株式会社 Rotation drive device for centrifuge
TWM269966U (en) * 2005-01-21 2005-07-11 Tian-Ju Ruan Plasmapheresis centrifuge bowl
EP1683579A1 (en) * 2005-01-25 2006-07-26 Jean-Denis Rochat Disposable device for the continuous separation by centrifugation of a physiological liquid
EP1683578A1 (en) * 2005-01-25 2006-07-26 Jean-Denis Rochat Centrifugal separator for a physiological liquid, in particular blood
EP1688183A1 (en) * 2005-02-03 2006-08-09 Jean-Denis Rochat Method and disposable device for centrifugal separation of a physiologic liquid
EP1800754A1 (en) * 2005-12-21 2007-06-27 Jean-Denis Rochat Disposable blood centrifuge
EP1825874A1 (en) * 2006-02-28 2007-08-29 Jean-Denis Rochat Process and bowl for continuous centrifugal washing and separation of blood fractions
EP1911520A1 (en) * 2006-10-10 2008-04-16 Jean-Denis Rochat Disposable set for separating blood or for washing blood components

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2963219A (en) * 1956-04-26 1960-12-06 Separator Ab System for continuous operation of series connected hermetically closed centrifugal separators
JPS56166957A (en) * 1980-05-26 1981-12-22 Asahi Chem Ind Co Ltd Apparatus for communicating fluid
EP0297216A1 (en) * 1987-04-08 1989-01-04 DIDECO S.p.A. Centrifugation bowl for the continuous centrifugation of blood
JPH09192215A (en) * 1996-01-17 1997-07-29 Takaharu Nakane Centrifugal bowl
US5851169A (en) * 1996-01-31 1998-12-22 Medtronic Electromedics, Inc. Rotary plate and bowl clamp for blood centrifuge
DE19822191C1 (en) * 1998-05-16 1999-08-19 Braunschweigische Masch Bau Discontinuous centrifuge with a cleaning out system
EP1057534A1 (en) * 1999-06-03 2000-12-06 Haemonetics Corporation Centrifugation bowl with filter core

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 006, no. 054 (C - 097) 9 April 1982 (1982-04-09) *
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 11 28 November 1997 (1997-11-28) *

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