EP1680167A1 - Combined positive and negative pressure assist ventilation - Google Patents
Combined positive and negative pressure assist ventilationInfo
- Publication number
- EP1680167A1 EP1680167A1 EP04789758A EP04789758A EP1680167A1 EP 1680167 A1 EP1680167 A1 EP 1680167A1 EP 04789758 A EP04789758 A EP 04789758A EP 04789758 A EP04789758 A EP 04789758A EP 1680167 A1 EP1680167 A1 EP 1680167A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- patient
- negative pressure
- positive
- level
- pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009423 ventilation Methods 0.000 title claims abstract description 99
- 210000001015 abdomen Anatomy 0.000 claims abstract description 98
- 210000000038 chest Anatomy 0.000 claims abstract description 89
- 210000004072 lung Anatomy 0.000 claims abstract description 43
- 238000000034 method Methods 0.000 claims abstract description 42
- 230000003434 inspiratory effect Effects 0.000 claims description 74
- 230000001537 neural effect Effects 0.000 claims description 53
- 230000004913 activation Effects 0.000 claims description 51
- 230000003187 abdominal effect Effects 0.000 claims description 41
- 230000000694 effects Effects 0.000 claims description 25
- 210000003205 muscle Anatomy 0.000 claims description 16
- 230000003247 decreasing effect Effects 0.000 claims description 6
- 230000000004 hemodynamic effect Effects 0.000 claims description 6
- 230000002411 adverse Effects 0.000 claims description 4
- 208000000782 Intrinsic Positive-Pressure Respiration Diseases 0.000 claims description 3
- 238000013213 extrapolation Methods 0.000 claims description 3
- 230000001256 tonic effect Effects 0.000 claims description 3
- 230000001360 synchronised effect Effects 0.000 abstract description 4
- 230000000241 respiratory effect Effects 0.000 description 11
- 210000000936 intestine Anatomy 0.000 description 5
- 230000029058 respiratory gaseous exchange Effects 0.000 description 4
- 210000003019 respiratory muscle Anatomy 0.000 description 4
- 210000003281 pleural cavity Anatomy 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 210000003238 esophagus Anatomy 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 210000000779 thoracic wall Anatomy 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- PGOOBECODWQEAB-UHFFFAOYSA-N (E)-clothianidin Chemical compound [O-][N+](=O)\N=C(/NC)NCC1=CN=C(Cl)S1 PGOOBECODWQEAB-UHFFFAOYSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010061688 Barotrauma Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 201000003144 pneumothorax Diseases 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 230000003519 ventilatory effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H31/00—Artificial respiration or heart stimulation, e.g. heart massage
- A61H31/02—"Iron-lungs", i.e. involving chest expansion by applying underpressure thereon, whether or not combined with gas breathing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes operated by electrical means
- A61M16/022—Control means therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H31/00—Artificial respiration or heart stimulation, e.g. heart massage
- A61H31/02—"Iron-lungs", i.e. involving chest expansion by applying underpressure thereon, whether or not combined with gas breathing means
- A61H2031/025—"Iron-lungs", i.e. involving chest expansion by applying underpressure thereon, whether or not combined with gas breathing means using the same pump for pressure and vacuum, not being driven at the respiratory rate, e.g. blowers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
- A61H2201/50—Control means thereof
- A61H2201/5058—Sensors or detectors
- A61H2201/5061—Force sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2205/00—Devices for specific parts of the body
- A61H2205/08—Trunk
- A61H2205/083—Abdomen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/08—Other bio-electrical signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/60—Muscle strain, i.e. measured on the user
Definitions
- the present invention relates to combined positive and negative pressure assist ventilation of a patient.
- Mechanical assist ventilation is delivered to a patient in order to maintain adequate alveolar ventilation by partially or totally substituting the function of the presumably weak or failing respiratory muscle(s).
- a negative pressure around the patient's ribcage and/or abdomen the so-called negative pressure assist ventilation.
- negative pressure assist ventilation creates a partial vacuum around the patient's ribcage and/or abdomen to induce inspiration. This mode of mechanical assist ventilation proved useful, but restricted physical access to the patient during ventilation.
- excessive inspiratory loads imposed by the patient's abdomen and/or ribcage may occur with obesity, reduced compliance due to abdominal distension, dynamic hyperinflation, and/or deformities of the chest wall.
- a method of delivering combined positive and negative pressure assist ventilation to a patient comprising applying a positive pressure to the patient's airways to inflate the patient's lungs, applying a negative pressure around the patient's ribcage and/or abdomen in order to reduce a load imposed by the ribcage and/or abdomen on the patient's lungs, and synchronizing application of the positive and negative pressures.
- the present invention also relates to a system for delivering combined positive and negative pressure assist ventilation to a patient, comprising first means for applying a positive pressure to the patient's airways to inflate the patient's lungs, second means for applying a negative pressure around the patient's ribcage and/or abdomen in order to reduce a load imposed by the ribcage and/or abdomen on the patient's lungs, and means for synchronizing operation of the first and second pressure-applying means.
- the present invention is further concerned with a system for delivering combined positive and negative pressure assist ventilation to a patient, comprising a positive pressure ventilator connected to the patient's airways for applying a positive pressure to the patient's airways to inflate the patient's lungs, a negative pressure ventilator installed on the patient's ribcage and/or abdomen for applying a negative pressure around the patient's ribcage and/or abdomen in order to reduce a load imposed by the ribcage and/or abdomen on the patient's lungs, and a controller for synchronising operation of the positive and negative pressure ventilators.
- a positive pressure ventilator connected to the patient's airways for applying a positive pressure to the patient's airways to inflate the patient's lungs
- a negative pressure ventilator installed on the patient's ribcage and/or abdomen for applying a negative pressure around the patient's ribcage and/or abdomen in order to reduce a load imposed by the ribcage and/or abdomen on the patient's
- Figure 1 is a flow chart of a non-restrictive illustrative embodiment of the method according to the present invention, for applying both a positive pressure to the patient's airways in order to inflate the lungs and a negative pressure around the patient's ribcage and/or abdomen in order to reduce the load imposed by the ribcage and/or abdomen on the lungs;
- Figure 2 is a block diagram of a non-restrictive illustrative embodiment of the system according to the present invention, for applying both a positive pressure to the patient's airways in order to inflate the lungs and a negative pressure around the patient's ribcage and/or abdomen in order to reduce the load imposed by the ribcage and/or abdomen on the lungs;
- Figure 3 is a side elevational view of an example of negative pressure ventilator
- Figure 4 is a flow chart of a first non-restrictive illustrative embodiment of process for applying the positive pressure to the patient's airways in order to inflate the lungs;
- Figure 5 is a flow chart of a second non-restrictive illustrative embodiment of process for applying the positive pressure to the patient's airways in order to inflate the lungs;
- Figure 6 is a flow chart of a first non-restrictive illustrative embodiment of process for applying a negative pressure around the patient's ribcage and/or abdomen in order to reduce the load imposed by the ribcage and/or abdomen on the lungs;
- Figure 7 is a flow chart of a second non-restrictive illustrative embodiment of process for applying a negative pressure around the patient's ribcage and/or abdomen in order to reduce the load imposed by the ribcage and/or abdomen on the lungs;
- Figure 8 is a flow chart of a third non-restrictive illustrative embodiment of process for applying a negative pressure around the patient's ribcage and/or abdomen in order to reduce the load imposed by the ribcage and/or abdomen on the lungs.
- a positive pressure is applied to the patient's lungs in order to inflate the lungs and a negative pressure is applied around the patient's ribcage and/or abdomen to reduce the load imposed by the ribcage and/or abdomen on the lungs.
- the method according to the non-restrictive illustrative embodiment of i the present invention comprises, as illustrated in Figure 1 , the following operations:
- Positive pressure is applied to the patient's airways to deliver assist ventilation, i.e. to substitute respiratory muscles' work to inflate the lungs.
- negative pressure is applied around the patient's ribcage and/or abdomen to reduce the load imposed by the ribcage and/or abdomen on the lungs. More specifically, the negative pressure assist substitutes for respiratory muscles' work to displace the patient's ribcage and/or abdomen.
- This operation consists of synchronizing application of positive pressure to the patient's airways and negative pressure to the patient's ribcage and/or abdomen.
- the operations 101-103 of Figure 1 can be performed through the system of Figures 2 and 3.
- the system of Figure 2 for delivering combined positive and negative pressure assist ventilation to a patient first comprises a positive pressure ventilator 201 for applying positive pressure assist ventilation (flow and/or volume) required to overcome the elastic and resistive loads related to inflation of the patient's lungs. More specifically, the positive pressure ventilator 201 will apply a positive pressure to the patient's airways to inflate the patient's lungs.
- positive pressure assist ventilation are described in US Patent No. 5,820,560 granted to Sinderby et al on October 13, 1998 and US Patent No. 6,588,423 (Sinderby) issued on July 8, 2003. The subject matter of these two US patents is herein incorporated by reference.
- the system of Figure 2 further comprises a negative pressure ventilator
- the negative pressure ventilator 202 structured for applying a negative pressure (flow and/or volume) around the patient's ribcage and/or abdomen to cancel and/or reduce the load caused by the ribcage and/or abdomen on the patient's lungs.
- a negative pressure ventilator 202 comprises a ventilator shell 301 , a patient 302 requiring negative pressure ventilatory assist wearing this ventilator shell 301.
- any other device for delivering negative pressure could of course be used in combination with the neural controller 203 of Figure 2, e.g. a cuirass, an iron lung, a poncho, etc.
- the device for delivering negative pressure does not need to be leak proof since the neural controller such as 203 will compensate for such leak.
- the ventilator shell 301 extends over the ribcage and abdomen area of the patient 302 and consists of two half-shell sections 303 and 304 that are not identical but respectively shaped to serve as ventral and dorsal half-shell sections. As illustrated in Figure 3, the half-shell sections 303 and 304 co- operate to enclose the major portion of the ribcage and abdomen of the patient 302.
- the shell sections 303 and 304 are firmly secured together on opposite sides of the patient's body by respective pairs of clamps 305.
- sealing lips 306 are intended to press against the skin of the patient 302 and thereby bound an airtight chamber 307 within the shell 301 for application of a negative pressure to the patient's ribcage and abdomen.
- Seals such as 308 are provided for sealing the joints between the two half-shell sections 303 and 304 on the opposite sides of the patient's body, thereby making these joints airtight.
- the ventilator 202 produces a negative pressure or vacuum in the chamber 307 to cancel and/or reduce the load of the patient's ribcage and abdomen on the lungs.
- the negative pressure or vacuum is applied to the chamber 307 through a port 309 in the ventral half-shell section 303.
- Negative pressure ventilators are believed to be otherwise well known to those of ordinary skill in the art and accordingly will not be further described in the present specification.
- the system of Figure 2 further comprises a controller 203 used to control the positive and negative pressure ventilators 201 and 202.
- the controller 203 synchronizes triggering and termination of the application, during inspiration, of positive pressure to the patient's airways and negative pressure around the patient's ribcage and/or abdomen.
- the controller 203 derives triggering and termination signals 204 and 208 applied to the ventilators 201 and 202, respectively.
- the signals 204 and 208 can be derived from neural inspiratory activation, for example electrical activity of the patient's diaphragm or other respiratory-related muscle, detected through a sensor 205.
- a non-restrictive example of neural triggering and termination of assist ventilation is described in the above mentioned US Patent No. 6,588,423 granted Sinderby on July 8, 2003.
- the level of positive pressure applied to the patient's lungs during inspiration can be manually set by the medical personnel or adjusted as a function of the neural inspiratory activation, for example the electrical activity of the patient's diaphragm or other respiration-related muscle.
- the controller 203 produces a positive pressure level control signal 209 for example in response to the electrical activity of the patient's diaphragm or other respiratory-related muscle as detected by the sensor 205.
- the signal 209 controls the ventilator 201 to adjust the level of assist ventilation positive pressure Oto the required level.
- the level of positive pressure applied to the patient's lungs will be adjusted in proportion to the level of electrical activity of the patient's diaphragm or other respiratory-related muscle.
- An example of positive pressure assist level adjustment is described in the above mentioned US Patent No. 5,820,560 granted to Sinderby et al on October 13, 1998.
- the level of negative pressure applied around the patient's ribcage and/or abdomen can be adjusted as a fraction of the positive pressure delivered to the patient; alternatively, 50% of the pressure target can be delivered to the patient as positive pressure and the other 50% of the pressure target can be delivered as negative pressure.
- a more physiological approach would be to use feedback from the abdominal pressure.
- the controller 203 produces, for that purpose, a negative pressure level control signal 210 applied to the negative pressure ventilator 202.
- the abdominal pressure feedback supplied to the controller 203 for producing the signal 210 and controlling the level of negative pressure applied around the patient's ribcage and/or abdomen could be obtained via a pressure sensor 206 located, for example, in the stomach/upper intestines, urine bladder, rectum/lower intestines, etc. This process will be described in detail in the following description.
- the abdominal pressure can be measured, for example, through a small gastric balloon mounted on an esophageal catheter and inserted in the stomach/upper intestines.
- This small gastric balloon inflated with gas, will be subjected to the abdominal pressure and associated with an outside gas pressure detector for detecting this abdominal pressure.
- pressure can be measured through an extrapulmonary pressure sensor 207.
- This extrapulmonary pressure sensor 207 will be located, for example, in the patient's esophagus or pleural space.
- this extrapulmonary pressure sensor 207 can comprise a small balloon mounted on an esophageal catheter and inserted in the patient's esophagus or pleural space.
- This small balloon inflated with gas, will be subjected to the intrathoracic pressure and associated with an outside gas pressure detector for detecting the transpulmonary pressure.
- Application of negative pressure can then be quantified with respect to how much it reduces transpulmonary pressure i.e. the pressure distending lung including airways and alveoli.
- an intrathoracic pressure estimate could be obtained by measuring an airway pressure deflection during a patient's airway occlusion.
- this includes an extrapolation for the period between the onset of electrical activity of the patient's diaphragm activity and the onset of the patient's airway pressure deflection.
- the abdominal pressure can be measured through any other suitable means known to those of ordinary skill in the art and capable of measuring abdominal pressure from locations as various as the patient's airways, esophageus, pleural space, stomach/upper intestines, urine bladder, rectum/lower intestines, etc.
- Application of positive pressure assist ventilation (101 of Figure 1)
- neural inspiratory activation is detected through the sensor 205 of Figure 2.
- the sensor 205 can detect electrical activity of the patient's diaphragm or other respiratory-related muscle.
- a non-limitative example of detection of the electrical activity of the patient's diaphragm is described in the above mentioned US Patent No. 5,820,560 granted to Sinderby et al on October 13, 1998.
- the controller 203 controls the positive pressure ventilator 201 through the level control signal 209 to apply to the patient's airways a level of positive pressure adjusted as a function of the detected neural inspiratory activation, for example the electrical activity of the patient's diaphragm or other respiratory-related muscle.
- a level of positive pressure applied to the patient's airways can be proportional to the detected level of neural inspiratory activation.
- inspiratory proportional pressure assist ventilation is described in the above mentioned US Patent No. 5,820,560 granted to Sinderby et al on October 13, 1998.
- the controller 203 synchronizes the triggering and termination of the cyclically induced positive pressure assist ventilation to the patient's spontaneous breathing.
- the controller 203 derives the triggering and termination signal 204, applied to the ventilator 201 , from the neural inspiratory activation for example the electrical activity of the patient's diaphragm or other respiratory-related muscle detected through the sensor 205.
- a non-restrictive example of neural triggering and termination of assist ventilation is described in the above mentioned US Patent No. 6,588,423 granted Sinderby on July 8, 2003.
- Operations 401-403 can be performed every inspiratory cycle.
- the inspiratory cycle can be divided into a plurality of segments and operations 401 and 402 can be performed every cycle segment.
- the non-limitative process of Figure 5 first determines a target level of the neural inspiratory activation, for example the electrical activity of the patient's diaphragm or other respiratory-related muscle.
- this target level can be determined by the medical personnel for each individual patient depending on the condition of the patient. Operation 502
- the sensor 205 of Figure 2 detects the patient's neural inspiratory activation, for example the electrical activity of the patient's diaphragm or other respiratory-related muscle.
- Operation 503 If the controller 203 determines that the detected patient's neural inspiratory activation (Operation 502) is higher than the target level of neural inspiratory activation (Operation 501), operation 504 is performed. Operation 504
- the level of positive pressure applied to the patient's airways is increased, for example by a predetermined step. Operation 505
- Operation 506 is performed.
- Operation 506 The level of positive pressure applied to the patient's airways is decreased, for example by a predetermined step.
- Operation 507 If the controller 203 determines that the detected patient's neural inspiratory activation (Operation 502) is equal to the target level or within an acceptable range of the target level of the patient's neural inspiratory activation (Operation 501), Operation 508 is performed. Operation 508 The level of positive pressure applied to the patient's airways is not changed.
- the controller 203 synchronizes the triggering and termination of the cyclically induced positive pressure assist ventilation to the patient's spontaneous breathing.
- the controller 203 derives the triggering and termination signal 204, applied to the ventilator 201 , from the neural inspiratory activation for example the electrical activity of the patient's diaphragm or other respiratory-related muscle detected through the sensor 205 (Operation 502).
- the neural inspiratory activation for example the electrical activity of the patient's diaphragm or other respiratory-related muscle detected through the sensor 205 (Operation 502).
- a non-restrictive example of neural triggering and termination of assist ventilation is described in the above mentioned US Patent No. 6,588,423 granted Sinderby on July 8, 2003.
- Operations 502-508 can be performed every inspiratory cycle.
- the inspiratory cycle can be divided into a plurality of segments and operations 502-508 can be performed every cycle segment.
- operations 502-508 can also be applied for time segments longer than one inspiratory cycle.
- the simplest method for applying negative pressure around the patient's ribcage and/or abdomen consists of applying a fixed negative pressure around the ribcage and/or abdomen of the patient during inspiration and/or expiration.
- Operation 602 Triggering and termination of the application of negative pressure around the patient's ribcage and/or abdomen is synchronized with triggering and termination of the application of positive pressure to the patient's airways.
- Operations 601 and 602 can be performed every inspiratory cycle.
- the negative pressure application in 601 is not restricted to inspiration only; negative pressure can also be applied during the expiratory phase, where the magnitude of the negative pressure does not have to be same as during the inspiratory phase.
- neural inspiratory activation is detected through the sensor 205 of Figure 2.
- the sensor 205 can detect electrical activity of the patient's diaphragm or other respiratory-related muscle. Operation 702
- the controller 203 controls the negative pressure ventilator 202 through the level control signal 210 to apply a level of negative pressure around the patient's ribcage and/or abdomen as a function of the detected neural inspiratory activation, for example the electrical activity of the patient's diaphragm.
- the level of the negative pressure applied around the patient's ribcage and/or abdomen can be proportional to the detected level of neural inspiratory activation.
- inspiratory proportional pressure assist ventilation is described in the above mentioned US Patent No. 5,820,560 granted to Sinderby et al on October 13, 1998.
- Triggering and termination of the application of negative pressure around the patient's ribcage and/or abdomen is synchronized with triggering and termination of the application of positive pressure to the patient's airways.
- Operations 701-703 can be performed every inspiratory cycle.
- the inspiratory cycle can be divided into a plurality of segments and operations 701 and 702 can be performed every cycle segment.
- the non-limitative process of Figure 8 first determines a target level of abdominal pressure swing of the patient.
- the abdominal pressure swing is the variation of abdominal pressure during a complete cycle of inspiration.
- the target level of abdominal pressure swing can be determined on the basis of previously measured absolute, peak, mean and/or area/integral values of abdominal pressure swings with or without a range.
- the objective is to control the negative pressure assist ventilation so as to reduce the abdominal pressure swing during inspiration.
- this is achieved by setting a target level of abdominal pressure swing.
- the pressure sensor 206 of Figure 2 detect the patient's abdominal pressure during inspiration, using any method known to those of ordinary skill in the art, including those as described in the foregoing description.
- the patient's abdominal pressure swing is determined by the controller 203 from the patient's abdominal pressure detected during inspiration through the pressure sensor 206 of Figure 2 (Operation 801). Operation 804
- Operation 805 is conducted.
- Operation 805 The level of negative pressure applied around the ribcage and/or abdomen is increased, for example by a predetermined step.
- Operation 807 is performed. Operation 807
- the level of negative pressure applied around the ribcage and/or abdomen is decreased, for example by a predetermined step. Operation 808
- Operation 809 is performed.
- the level of negative pressure applied around the ribcage and/or abdomen is not changed.
- Triggering and termination of the application ot negative pressure around the patient's ribcage and/or abdomen is synchronized with triggering and termination of the application of positive pressure to the patient's airways.
- Operations 802-810 can be performed every inspiratory cycle.
- the inspiratory cycle can be divided into a plurality of segments and operations 802-809 can be performed every cycle segment.
- operations 802-810 can be performed during time periods longer than one inspiratory cycle.
- NEEP can be applied over the abdomen to adjust the end- expiratory lung-volume.
- NEEP can be applied in combination with inspiratory negative pressure assist ventilation or alone.
- NEEP can also be delivered in proportional response to tonic inspiratory muscle, for example the diaphragm, activation occurring during expiration.
- a device for carrying out combined positive and negative pressure assist ventilation will not obstruct patient access as negative pressure ventilation alone would, since the positive pressure ventilation could assume 100% of the assist while the negative pressure device is removed during patient access.
- the negative pressure applied around the patient's ribcage and/or abdomen eliminates both the load caused by the ribcage and/or abdomen on the patient's lungs and, thereby, the need for excessive positive pressure applied to the patient's airways.
- Cyclic and/or proportional application of negative pressure around the abdomen facilitates diaphragm movement and hence, reduces the risk for airway collapse in the dependent regions of the lungs.
- the positive and negative pressures can be adjusted to avoid application of excessive positive pressure to the patient's airways, and therefore to minimize hemodynamic adverse effects. Monitoring of hemodynamics will help to optimize the level of the negative pressure assist as well as the relative contribution of the positive and negative pressure assists in order to minimize these hemodynamic adverse effects.
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51444903P | 2003-10-23 | 2003-10-23 | |
PCT/CA2004/001851 WO2005039679A1 (en) | 2003-10-23 | 2004-10-21 | Combined positive and negative pressure assist ventilation |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1680167A1 true EP1680167A1 (en) | 2006-07-19 |
EP1680167A4 EP1680167A4 (en) | 2009-04-15 |
EP1680167B1 EP1680167B1 (en) | 2014-07-16 |
Family
ID=34520210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04789758.2A Active EP1680167B1 (en) | 2003-10-23 | 2004-10-21 | Combined positive and negative pressure assist ventilation |
Country Status (3)
Country | Link |
---|---|
US (1) | US7909034B2 (en) |
EP (1) | EP1680167B1 (en) |
WO (1) | WO2005039679A1 (en) |
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US7594508B2 (en) * | 2006-07-13 | 2009-09-29 | Ric Investments, Llc. | Ventilation system employing synchronized delivery of positive and negative pressure ventilation |
US8251876B2 (en) | 2008-04-22 | 2012-08-28 | Hill-Rom Services, Inc. | Breathing exercise apparatus |
WO2009149357A1 (en) | 2008-06-06 | 2009-12-10 | Nellcor Puritan Bennett Llc | Systems and methods for ventilation in proportion to patient effort |
US8302602B2 (en) | 2008-09-30 | 2012-11-06 | Nellcor Puritan Bennett Llc | Breathing assistance system with multiple pressure sensors |
JP5583454B2 (en) * | 2009-04-13 | 2014-09-03 | チェスト株式会社 | Respiratory impedance measuring device and respiratory impedance display method |
US8783250B2 (en) | 2011-02-27 | 2014-07-22 | Covidien Lp | Methods and systems for transitory ventilation support |
US8714154B2 (en) | 2011-03-30 | 2014-05-06 | Covidien Lp | Systems and methods for automatic adjustment of ventilator settings |
US9364624B2 (en) | 2011-12-07 | 2016-06-14 | Covidien Lp | Methods and systems for adaptive base flow |
US9498589B2 (en) | 2011-12-31 | 2016-11-22 | Covidien Lp | Methods and systems for adaptive base flow and leak compensation |
US9022031B2 (en) | 2012-01-31 | 2015-05-05 | Covidien Lp | Using estimated carinal pressure for feedback control of carinal pressure during ventilation |
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Also Published As
Publication number | Publication date |
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WO2005039679A1 (en) | 2005-05-06 |
EP1680167B1 (en) | 2014-07-16 |
EP1680167A4 (en) | 2009-04-15 |
US20080115786A1 (en) | 2008-05-22 |
US7909034B2 (en) | 2011-03-22 |
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