EP1667516A4 - Method of selecting animal models from animals which have been subject to mutagenesis, and the use of myb transcription factors for screening - Google Patents

Method of selecting animal models from animals which have been subject to mutagenesis, and the use of myb transcription factors for screening

Info

Publication number
EP1667516A4
EP1667516A4 EP04761204A EP04761204A EP1667516A4 EP 1667516 A4 EP1667516 A4 EP 1667516A4 EP 04761204 A EP04761204 A EP 04761204A EP 04761204 A EP04761204 A EP 04761204A EP 1667516 A4 EP1667516 A4 EP 1667516A4
Authority
EP
European Patent Office
Prior art keywords
mutagenesis
animals
screening
subject
animal models
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04761204A
Other languages
German (de)
French (fr)
Other versions
EP1667516A1 (en
Inventor
Douglas J Hilton
Warren S Alexander
Marina Carpinelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Walter and Eliza Hall Institute of Medical Research
Original Assignee
Walter and Eliza Hall Institute of Medical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2003904850A external-priority patent/AU2003904850A0/en
Application filed by Walter and Eliza Hall Institute of Medical Research filed Critical Walter and Eliza Hall Institute of Medical Research
Publication of EP1667516A1 publication Critical patent/EP1667516A1/en
Publication of EP1667516A4 publication Critical patent/EP1667516A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/03—Animals modified by random mutagenesis, e.g. using ENU, chemicals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP04761204A 2003-08-29 2004-08-27 Method of selecting animal models from animals which have been subject to mutagenesis, and the use of myb transcription factors for screening Withdrawn EP1667516A4 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
AU2003904850A AU2003904850A0 (en) 2003-08-29 Drug Targets and Methods of Determining Same
AU2003904686A AU2003904686A0 (en) 2003-08-29 Targets for Therapeutic Intervention
AU2003905351A AU2003905351A0 (en) 2003-09-01 Targets for Therapeutic Intervention
AU2003904726A AU2003904726A0 (en) 2003-09-01 Drug Targets and Methods of Determining Same
AU2003907191A AU2003907191A0 (en) 2003-12-24 Targets for Therapeutic Intervention
PCT/AU2004/001167 WO2005020677A1 (en) 2003-08-29 2004-08-27 Method of selecting animal models from animals which have been subject to mutagenesis, and the use of myb transcription factors for screening

Publications (2)

Publication Number Publication Date
EP1667516A1 EP1667516A1 (en) 2006-06-14
EP1667516A4 true EP1667516A4 (en) 2009-11-11

Family

ID=34280079

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04761204A Withdrawn EP1667516A4 (en) 2003-08-29 2004-08-27 Method of selecting animal models from animals which have been subject to mutagenesis, and the use of myb transcription factors for screening

Country Status (2)

Country Link
EP (1) EP1667516A4 (en)
WO (1) WO2005020677A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009046483A1 (en) * 2007-10-08 2009-04-16 The Walter And Eliza Hall Institute Of Medical Research Therapeutic protocol for the treatment or prevention of thrombocytopenia

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992019195A1 (en) 1991-04-25 1992-11-12 Brown University Research Foundation Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
US5854217A (en) 1992-09-28 1998-12-29 Bearsden Bio, Inc. Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function
JPH08510274A (en) 1993-04-27 1996-10-29 サイトセラピュティックス インコーポレイテッド Membrane formed by acrylonitrile-based polymer
EP0708670A4 (en) 1993-06-23 1998-07-01 Cytotherapeutics Inc Method and apparatus for sealing implantable, membrane encapsulation devices
WO1995005452A2 (en) 1993-08-12 1995-02-23 Cytotherapeutics, Inc. Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
US5550050A (en) 1994-04-15 1996-08-27 Cytotherapeutics, Inc. Method for implanting encapsulated cells in a host
US5833979A (en) 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
US5834029A (en) 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
.PERCEC I, THORVALDSEN JL, PLENGE RM, KRAPP CJ, NADEAU JH, WILLARD HF, BARTOLOMEI MS.: "An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse", GENETICS., vol. 164, no. 4, 1 August 2003 (2003-08-01), pages 1481 - 1494, XP002542207 *
CUMMINGS CJ, SUN Y, OPAL P, ANTALFFY B, MESTRIL R, ORR HT, DILLMANN WH, ZOGHBI HY.: "Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice.", HUM MOL GENET., vol. 10, no. 14, 1 July 2001 (2001-07-01), pages 1511 - 1518, XP002542205 *
J RULAND, C SIRARD, A E D MACPHERSON, A WAKEHAM, L LI, J L DE LA POMPA, S N. COHEN, T W. MAK: "p53 Accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101", PROC NATL ACAD SCI U S A., vol. 98, no. 4, 13 February 2001 (2001-02-13), pages 1859 - 1864, XP002542206 *
JORGENSEN E M ET AL: "THE ART AND DESIGN OF GENETIC SCREENS: CAENORHABDITIS ELEGANS", NATURE REVIEWS GENETICS, MACMILLAN MAGAZINES, GB, vol. 3, no. 5, 1 May 2002 (2002-05-01), pages 356 - 359, XP008019110 *
NOLAN PM, HUGILL A, COX RD.: "NU mutagenesis in the mouse: application to human genetic disease.", BRIEF FUNCT GENOMIC PROTEOMIC., vol. 1, no. 3, October 2002 (2002-10-01), pages 278 - 289, XP002542203 *
RUSS A. ET AL.: "9: Chemical mutagenesis in the mouse : a powerful tool in drug target identification and validation", 1 January 2003, JOHM WILEY &SONS, XP002542208 *
See also references of WO2005020677A1 *
THAUNG C, WEST K, CLARK BJ, MCKIE L, MORGAN JE, ARNOLD K, NOLAN PM, PETERS J, HUNTER AJ, BROWN SD, JACKSON IJ, CROSS SH.: "Novel ENU-induced eye mutations in the mouse: models for human eye disease.", HUM MOL GENET., vol. 11, no. 7, April 2002 (2002-04-01), pages 755 - 767, XP002542204 *

Also Published As

Publication number Publication date
EP1667516A1 (en) 2006-06-14
WO2005020677A1 (en) 2005-03-10

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

RIN1 Information on inventor provided before grant (corrected)

Inventor name: CARPINELLI, MARINA

Inventor name: ALEXANDER, WARREN, S.

Inventor name: HILTON, DOUGLAS, J.

DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 15/85 20060101ALI20090826BHEP

Ipc: A01K 67/00 20060101AFI20050314BHEP

Ipc: A01K 67/027 20060101ALI20090826BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20090915

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