EP1620117A4 - IMPROVED ANTITUMORAL TREATMENTS - Google Patents
IMPROVED ANTITUMORAL TREATMENTSInfo
- Publication number
- EP1620117A4 EP1620117A4 EP04720399A EP04720399A EP1620117A4 EP 1620117 A4 EP1620117 A4 EP 1620117A4 EP 04720399 A EP04720399 A EP 04720399A EP 04720399 A EP04720399 A EP 04720399A EP 1620117 A4 EP1620117 A4 EP 1620117A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- improved antitumoral
- antitumoral treatments
- treatments
- improved
- antitumoral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45412503P | 2003-03-12 | 2003-03-12 | |
PCT/US2004/007606 WO2004080421A2 (en) | 2003-03-12 | 2004-03-12 | Improved antitumoral treatments |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1620117A2 EP1620117A2 (en) | 2006-02-01 |
EP1620117A4 true EP1620117A4 (en) | 2009-07-29 |
Family
ID=32990868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04720399A Withdrawn EP1620117A4 (en) | 2003-03-12 | 2004-03-12 | IMPROVED ANTITUMORAL TREATMENTS |
Country Status (13)
Country | Link |
---|---|
US (2) | US7576188B2 (zh) |
EP (1) | EP1620117A4 (zh) |
JP (1) | JP2006519848A (zh) |
KR (1) | KR20060002778A (zh) |
CN (3) | CN1761480B (zh) |
AU (1) | AU2004220451B2 (zh) |
CA (1) | CA2516572A1 (zh) |
MX (1) | MXPA05009741A (zh) |
NO (1) | NO20053947L (zh) |
NZ (1) | NZ541634A (zh) |
RU (1) | RU2341283C2 (zh) |
UA (2) | UA83022C2 (zh) |
WO (1) | WO2004080421A2 (zh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9803448D0 (en) | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
ES2288486T3 (es) * | 1999-11-15 | 2008-01-16 | Pharma Mar, S.A. | Tratamiento de canceres con aplidina. |
UA76718C2 (uk) | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Протипухлинні похідні аплідину |
CZ2003993A3 (cs) | 2000-10-12 | 2004-02-18 | Pharma Mar, S. A. | Léčivo pro léčení rakoviny podáváním aplidinu nebo analogu aplidinu a protektoru kosterního svalstva |
JP2006519848A (ja) | 2003-03-12 | 2006-08-31 | ファルマ・マール・ソシエダード・アノニマ | 改良された抗腫瘍治療 |
WO2004080477A1 (en) | 2003-03-12 | 2004-09-23 | Dana-Farber Cancer Institute, Inc. | Aplidine for multiple myeloma treatment |
HUE028055T2 (en) * | 2006-02-28 | 2016-11-28 | Pharma Mar Sa | Improved treatment of myeloma multiplex |
ITMI20070817A1 (it) * | 2007-04-19 | 2008-10-20 | Farmacetika Ltd | Composizione farmaceutica comprendente l-carnitina ed un agente antagonista dei recettori adenosinici di membrana, loro derivati e/o sali farmaceuticamente accettabili, e uso degli stessi nella preparazione di farmaci con effetto non tossico di inibi |
WO2008135793A1 (en) * | 2007-05-04 | 2008-11-13 | Pharma Mar S.A. | Combination of aplidine and carboplatin in anticancer treatments |
WO2009050296A1 (en) * | 2007-10-19 | 2009-04-23 | Pharma Mar, S.A. | Improved antitumoral treatments |
KR20100131474A (ko) * | 2008-03-07 | 2010-12-15 | 파르마 마르 에스.에이. | 개선된 항암치료 |
WO2010029158A1 (en) * | 2008-09-12 | 2010-03-18 | Pharma Mar, S.A. | Aplidine in the treatment of chronic myeloproliferative disorders |
CN104706599B (zh) * | 2013-12-11 | 2020-10-02 | 中国海洋大学 | 一种携带膜海鞘素化合物的冻干粉针剂 |
CN109462980B (zh) * | 2016-03-15 | 2022-02-08 | 奥莱松基因组股份有限公司 | 用于治疗血液恶性肿瘤的lsd1抑制剂的组合 |
JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001035974A2 (en) * | 1999-11-15 | 2001-05-25 | Pharma Mar S.A. | Aplidine treatment of cancers |
WO2002058688A1 (de) * | 2001-01-24 | 2002-08-01 | Mestex Ag | Verwendung von neurotoxischen substanzen für die herstellung eines mittels zur behandlung von gelenkschmerzen |
WO2003033013A1 (en) * | 2001-10-19 | 2003-04-24 | Pharma Mar, S.A. | Use of aplidine for the treatment of pancreatic cancer |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3161556D1 (en) | 1980-09-12 | 1984-01-05 | Univ Illinois | Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them |
US4950649A (en) | 1980-09-12 | 1990-08-21 | University Of Illinois | Didemnins and nordidemnins |
US4493796A (en) | 1980-09-12 | 1985-01-15 | Board Of Trustees, Univ. Of Ill. | Didemnins A, B, C, and derivatives thereof, as antiviral agents |
IT1153974B (it) | 1982-09-23 | 1987-01-21 | Erba Farmitalia | Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento |
DE3684868D1 (de) | 1985-09-20 | 1992-05-21 | Cernitin Sa | Verwendung von pflanzenpollenextrakten zur herstellung von das wachstum von tumorzellen hemmenden pharmazeutischen praeparaten und verfahren zu ihrer herstellung. |
US4948791A (en) | 1989-04-10 | 1990-08-14 | The Board Of Trustees Of The University Of Illinois | Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum |
GB8922026D0 (en) | 1989-09-29 | 1989-11-15 | Pharma Mar Sa | Novel anti-viral and cytotoxic agent |
US20030148933A1 (en) * | 1990-10-01 | 2003-08-07 | Pharma Mar S.A. | Derivatives of dehydrodidemnin B |
US5018188A (en) | 1989-12-20 | 1991-05-21 | Motorola, Inc. | Microphone-controller with multifunction, single conductor |
DE4120327A1 (de) | 1991-06-20 | 1992-12-24 | Basf Ag | Neue peptide, ihre herstellung und verwendung |
US5482726A (en) * | 1992-07-14 | 1996-01-09 | Us Harvest Technologies Corporation | Method for reducing contamination of shellfish |
US5580871A (en) | 1992-11-20 | 1996-12-03 | The Dupont Merck Pharmaceutical Company | 4-Heteroaryl- 1,4-dihydropyridine compounds with calcium agonist and alpha1 -antagonist activity |
US5462726A (en) | 1993-12-17 | 1995-10-31 | Bristol-Myers Squibb Company | Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents |
ES2102322B1 (es) | 1995-07-13 | 1998-03-01 | Pharma Mar Sa | Procedimiento de preparacion de didemnina a. |
US6156724A (en) | 1996-06-07 | 2000-12-05 | Rinehart; Kenneth L. | Uses of didemnins as immunomodulating agents |
ES2135360T3 (es) | 1996-07-03 | 2002-05-16 | Paxton C G Ltd | Recipiente. |
EP0973518B1 (en) | 1996-10-24 | 2006-03-29 | The Board Of Trustees Of The University Of Illinois | Semi-synthetic studies toward didemnin analogues |
DE69723728T2 (de) | 1996-10-24 | 2004-06-03 | The Board Of Trustees For The University Of Illinois, Urbana | Totalsynthese des amino hip analogen von didemnin a |
US6034058A (en) | 1997-04-15 | 2000-03-07 | Rinehart; Kenneth L. | Semi-synthetic alanyl dilemnin analogs |
CA2288639A1 (en) * | 1997-05-07 | 1998-11-12 | Pharma Mar, S.A. | Aplidine as an l-type calcium channel enhancer |
GB9803448D0 (en) | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
GB9821975D0 (en) | 1998-10-08 | 1998-12-02 | Pharma Mar Sa | New cytotoxic alkaloids |
US6245759B1 (en) | 1999-03-11 | 2001-06-12 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
SE9904175D0 (sv) | 1999-11-18 | 1999-11-18 | Pharmacia & Upjohn Diag Ab | Assay device and use thereof |
JP2003535048A (ja) | 2000-04-07 | 2003-11-25 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | タマンダリンおよびジデムニン同族体およびそれらの作成および使用法 |
EP2052742A1 (en) * | 2000-06-20 | 2009-04-29 | Biogen Idec Inc. | Treatment of B-cell associated diseases such as malignancies and autoimmune diseases using a cold anti-CD20 antibody/radiolabeled anti-CD22 antibody combination |
UA76718C2 (uk) * | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Протипухлинні похідні аплідину |
CZ2003993A3 (cs) | 2000-10-12 | 2004-02-18 | Pharma Mar, S. A. | Léčivo pro léčení rakoviny podáváním aplidinu nebo analogu aplidinu a protektoru kosterního svalstva |
MXPA03003230A (es) | 2000-10-12 | 2004-12-03 | Pharma Mar Sa | Tratamiento de canceres. |
ATA13422001A (de) | 2001-08-23 | 2003-09-15 | Plasser Bahnbaumasch Franz | Maschine zur bearbeitung einer gleisbettung |
JP2006519848A (ja) * | 2003-03-12 | 2006-08-31 | ファルマ・マール・ソシエダード・アノニマ | 改良された抗腫瘍治療 |
WO2004080477A1 (en) | 2003-03-12 | 2004-09-23 | Dana-Farber Cancer Institute, Inc. | Aplidine for multiple myeloma treatment |
-
2004
- 2004-03-12 JP JP2006507125A patent/JP2006519848A/ja active Pending
- 2004-03-12 CN CN2004800067241A patent/CN1761480B/zh not_active Expired - Lifetime
- 2004-03-12 RU RU2005126819/15A patent/RU2341283C2/ru not_active IP Right Cessation
- 2004-03-12 MX MXPA05009741A patent/MXPA05009741A/es unknown
- 2004-03-12 NZ NZ541634A patent/NZ541634A/en not_active IP Right Cessation
- 2004-03-12 WO PCT/US2004/007606 patent/WO2004080421A2/en active Application Filing
- 2004-03-12 UA UAA200508279A patent/UA83022C2/uk unknown
- 2004-03-12 KR KR1020057015665A patent/KR20060002778A/ko not_active Application Discontinuation
- 2004-03-12 CN CNB2004800051794A patent/CN100409895C/zh not_active Expired - Fee Related
- 2004-03-12 US US10/546,750 patent/US7576188B2/en not_active Expired - Fee Related
- 2004-03-12 AU AU2004220451A patent/AU2004220451B2/en not_active Ceased
- 2004-03-12 EP EP04720399A patent/EP1620117A4/en not_active Withdrawn
- 2004-03-12 CN CNA2009100039994A patent/CN101579520A/zh active Pending
- 2004-03-12 CA CA002516572A patent/CA2516572A1/en not_active Abandoned
- 2004-12-03 UA UAA200509530A patent/UA82089C2/uk unknown
-
2005
- 2005-08-24 NO NO20053947A patent/NO20053947L/no not_active Application Discontinuation
-
2009
- 2009-04-30 US US12/433,028 patent/US20090227490A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001035974A2 (en) * | 1999-11-15 | 2001-05-25 | Pharma Mar S.A. | Aplidine treatment of cancers |
WO2002058688A1 (de) * | 2001-01-24 | 2002-08-01 | Mestex Ag | Verwendung von neurotoxischen substanzen für die herstellung eines mittels zur behandlung von gelenkschmerzen |
WO2003033013A1 (en) * | 2001-10-19 | 2003-04-24 | Pharma Mar, S.A. | Use of aplidine for the treatment of pancreatic cancer |
Non-Patent Citations (9)
Title |
---|
"Didemnin B", DRUGS OF THE FUTURE 1992, vol. 17, no. 1, 1992, pages 54 - 55, XP008107010 * |
BANERJEE D ET AL: "Drug combination studies with Aplidin in experimental leukemia and lymphoma models.", LEUKEMIA, vol. 17, no. 3, 6 March 2003 (2003-03-06), 5TH INTERNATIONAL SYMPOSIUM ON LEUKEMIA AND LYMPHOMA; AMSTERDAM, NETHERLANDS; MARCH 12-15, 2003, pages 686, XP002531925 * |
BANERJEE DEBABRATA ET AL: "Potential clinical relevance of drug combination studies with aplidine in experimental leukemia and lymphoma models.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 44, July 2003 (2003-07-01), 94TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; WASHINGTON, DC, USA; JULY 11-14, 2003, pages 530, XP001537121 * |
CHESON B D: "New chemotherapeutic agents for the treatment of low-grade non-Hodgkin's lymphomas", SEMINARS IN ONCOLOGY, vol. 20, no. SUPPL. 5, 1993, pages 96 - 110, XP008107011 * |
RAYMOND E ET AL: "PRELIMINARY RESULTS OF A PHASE I AND PHARMACOKINETIC STUDY OF APLIDINE GIVEN AS A 24-HOUR INFUSION EVERY 2 WEEKS IN PATIENTS WITHSOLID TUMORS AND NON HODGKIN'S LYMPHOMAS", PROCEEDINGS OF THE 91ST ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. SAN FRANCISCO, CA, APRIL 1 - 5, 2000, PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, PHILADELPHIA, PA : AACR, US, vol. VOL. 41, 2000, pages 611, XP001002420 * |
See also references of WO2004080421A2 * |
VERA M D ET AL: "Natural products as probes of cell biology: 20 Years of didemnin research", MEDICINAL RESEARCH REVIEWS, vol. 22, no. 2, 2002, pages 102 - 145, XP002531923 * |
WHELAN P: "The medical treatment of metastatic renal cell cancer", EAU UPDATE SERIES, vol. 1, no. 4, 2003, pages 237 - 246, XP002531924 * |
YAGODA A ET AL: "Cytotoxic chemotherapy for advanced renal cell carcinoma.", THE UROLOGIC CLINICS OF NORTH AMERICA, vol. 20, no. 2, 1993, pages 303 - 321, XP008107009 * |
Also Published As
Publication number | Publication date |
---|---|
US20060178298A1 (en) | 2006-08-10 |
MXPA05009741A (es) | 2005-11-16 |
RU2341283C2 (ru) | 2008-12-20 |
RU2005126819A (ru) | 2006-01-20 |
CN1761480A (zh) | 2006-04-19 |
AU2004220451B2 (en) | 2010-01-21 |
NO20053947D0 (no) | 2005-08-24 |
CN1753684A (zh) | 2006-03-29 |
UA83022C2 (uk) | 2008-06-10 |
JP2006519848A (ja) | 2006-08-31 |
AU2004220451A1 (en) | 2004-09-23 |
US20090227490A1 (en) | 2009-09-10 |
CN100409895C (zh) | 2008-08-13 |
WO2004080421A2 (en) | 2004-09-23 |
KR20060002778A (ko) | 2006-01-09 |
CN1761480B (zh) | 2012-09-26 |
CA2516572A1 (en) | 2004-09-23 |
CN101579520A (zh) | 2009-11-18 |
NO20053947L (no) | 2005-12-07 |
US7576188B2 (en) | 2009-08-18 |
WO2004080421A3 (en) | 2005-06-09 |
EP1620117A2 (en) | 2006-02-01 |
UA82089C2 (uk) | 2008-03-11 |
NZ541634A (en) | 2008-08-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20050802 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20090629 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 35/00 20060101ALI20090619BHEP Ipc: A61K 38/15 20060101AFI20090619BHEP |
|
17Q | First examination report despatched |
Effective date: 20091029 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
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INTG | Intention to grant announced |
Effective date: 20160324 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20160804 |