EP1545551A4 - Delivery of modulators of glutamate-mediated neurotransmission to the inner ear - Google Patents

Delivery of modulators of glutamate-mediated neurotransmission to the inner ear

Info

Publication number
EP1545551A4
EP1545551A4 EP02768820A EP02768820A EP1545551A4 EP 1545551 A4 EP1545551 A4 EP 1545551A4 EP 02768820 A EP02768820 A EP 02768820A EP 02768820 A EP02768820 A EP 02768820A EP 1545551 A4 EP1545551 A4 EP 1545551A4
Authority
EP
European Patent Office
Prior art keywords
glutamate
modulators
delivery
inner ear
mediated neurotransmission
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02768820A
Other languages
German (de)
French (fr)
Other versions
EP1545551A1 (en
Inventor
Jean-Luc Puel
Remy Pujol
Yves Christen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Durect Corp
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Durect Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM, Durect Corp filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Publication of EP1545551A1 publication Critical patent/EP1545551A1/en
Publication of EP1545551A4 publication Critical patent/EP1545551A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
EP02768820A 2002-09-06 2002-09-06 Delivery of modulators of glutamate-mediated neurotransmission to the inner ear Withdrawn EP1545551A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/028519 WO2004022069A1 (en) 2002-09-06 2002-09-06 Delivery of modulators of glutamate-mediated neurotransmission to the inner ear

Publications (2)

Publication Number Publication Date
EP1545551A1 EP1545551A1 (en) 2005-06-29
EP1545551A4 true EP1545551A4 (en) 2008-10-22

Family

ID=31975588

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02768820A Withdrawn EP1545551A4 (en) 2002-09-06 2002-09-06 Delivery of modulators of glutamate-mediated neurotransmission to the inner ear

Country Status (5)

Country Link
EP (1) EP1545551A4 (en)
JP (1) JP2006502158A (en)
AU (2) AU2002331830A1 (en)
CA (1) CA2497867A1 (en)
WO (1) WO2004022069A1 (en)

Families Citing this family (22)

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Publication number Priority date Publication date Assignee Title
US8268866B2 (en) * 2004-03-29 2012-09-18 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US20060063802A1 (en) 2004-03-29 2006-03-23 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US9072662B2 (en) 2004-03-29 2015-07-07 Auris Medical Ag Methods for the treatment of tinnitus induced by cochlear excitotoxicity
KR101189261B1 (en) * 2004-03-29 2012-10-09 앵스티띠 나셔날 드 라 쌍뜨 에 드 라 르셰르슈 메디깔 Use of an nmda receptor antagonist for the treatment of tinnitus induced by cochlear excitotoxicity
DE102005004343A1 (en) * 2005-01-25 2006-08-10 Eberhard-Karls-Universität Tübingen Universitätsklinikum Treatment of phantom phenomena
JP2008531726A (en) * 2005-03-04 2008-08-14 ニューロシステック コーポレイション Improved gacyclidine formulation
JP5058163B2 (en) * 2005-07-22 2012-10-24 メドトロニック，インコーポレイテッド Small pump that discharges medicine
ME01956B (en) * 2005-09-28 2015-05-20 Auris Medical Ag Pharmaceutical compositions for the treatment of inner ear disorders
CN104840416A (en) * 2005-09-28 2015-08-19 奥里斯医学股份有限公司 Medicinal composition for treating internal-ear disease
US8267905B2 (en) 2006-05-01 2012-09-18 Neurosystec Corporation Apparatus and method for delivery of therapeutic and other types of agents
US7803148B2 (en) 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
US20080145439A1 (en) * 2006-07-31 2008-06-19 Neurosystec Corporation Nanoparticle drug formulations
ES2377253T3 (en) * 2007-09-12 2012-03-23 Merz Pharma Gmbh & Co. Kgaa Neramexane for use in the treatment of subacute tinnitus
DE102007063210A1 (en) 2007-12-20 2009-06-25 Eberhard-Karls-Universität Tübingen Universitätsklinikum Medicines for the treatment of phantom phenomena
US8496957B2 (en) 2008-07-21 2013-07-30 Otonomy, Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
US9173864B2 (en) * 2008-10-22 2015-11-03 House Ear Institute Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor
EP2299976A4 (en) * 2008-12-22 2014-07-23 Otonomy Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
US20110294890A1 (en) * 2010-05-28 2011-12-01 Merz Pharma Gmbh & Co. Kgaa Neramexane for the treatment or prevention of inner ear disorders
US20150044200A1 (en) 2011-12-12 2015-02-12 Otolanum Ag Treatment of tinnitus through modulation of chloride co-transporter nkcc1 in the auditory system
BR112015017535A2 (en) 2013-01-22 2020-02-04 Vistagen Therapeutics Inc dosage forms and therapeutic uses of 1-4-chloroquinurenine
US10500392B2 (en) 2016-08-24 2019-12-10 Cochlear Limited Monitoring stimulating assembly insertion
WO2023038778A1 (en) 2021-08-19 2023-03-16 Innovative Health Strategies Llc A smart self-activating wearable device for automatically injecting medicines

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US6066652A (en) * 1995-08-02 2000-05-23 Tinnitus Forschungs-Und Entwicklungs Gmbh Method for treating diseases of the inner ear using adamantane derivatives
US6177434B1 (en) * 1997-12-16 2001-01-23 The United States Of America As Represented By The Secretary Of The Navy Prevention or reversal of sensorineural hearing loss (SNHL) through biologic mechanisms

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US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
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Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US6066652A (en) * 1995-08-02 2000-05-23 Tinnitus Forschungs-Und Entwicklungs Gmbh Method for treating diseases of the inner ear using adamantane derivatives
US6177434B1 (en) * 1997-12-16 2001-01-23 The United States Of America As Represented By The Secretary Of The Navy Prevention or reversal of sensorineural hearing loss (SNHL) through biologic mechanisms

Non-Patent Citations (12)

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Title
DENK D-M ET AL: "CAROVERINE IN TINNITUS TREATMENT A PLACEBO-CONTROLLED BLIND STUDY", ACTA OTO-LARYNGOLOGICA, SCANDINAVIAN UNIVERSITY PRESS, OSLO, NO, vol. 117, no. 6, 1 November 1997 (1997-11-01), pages 825 - 830, XP009043354, ISSN: 0001-6489 *
HIRBEC H ET AL: "GACYCLIDINE: A NEW NEUROPROTECTIVE AGENT ACTING AT THE N-METHYL-D-ASPARTATE RECEPTOR", CNS DRUG REVIEWS, BRANFORD, CT, US, vol. 2, no. 7, 1 January 2001 (2001-01-01), pages 172 - 198, XP008032600, ISSN: 1080-563X *
HOFFER M E ET AL: "Microdose gentamicin administration via the round window microcatheter: results in patients with Meniere's disease.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES OCT 2001, vol. 942, October 2001 (2001-10-01), pages 46 - 51, XP002494748, ISSN: 0077-8923 *
JACKSON LANCE E ET AL: "Chemical perfusion of the inner ear.", OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA JUN 2002, vol. 35, no. 3, June 2002 (2002-06-01), pages 639 - 653, XP009105345, ISSN: 0030-6665 *
LIU YE ET AL: "MK-801 protects against carbon monoxide-induced hearing loss", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 132, no. 2, 1995, pages 196 - 202, XP002494745, ISSN: 0041-008X *
OESTREICHERE ET AL: "Memantine suppresses the glutamatergic neurotransmission of mammalian inner hair cells", ORL, vol. 60, no. 1, 1 January 1998 (1998-01-01), BASEL. CH, pages 18 - 21, XP009105375 *
PARSONS C G ET AL: "Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist - A review of preclinical data", NEUROPHARMACOLOGY, PERGAMON PRESS, OXFORD, GB, vol. 38, no. 6, 1 June 1999 (1999-06-01), pages 735 - 767, XP002279262, ISSN: 0028-3908 *
PUEL J-L ET AL: "TRAITEMENT DES ACOUPHENES NOUVELLES PERSPECTIVES//THE TREATMENT OF TINNITUS AURIUM NEW PERSPECTIVES", PRESSE MEDICALE, PRESSE MEDICALE, PARIS, FR, vol. 31, no. 24, 13 July 2002 (2002-07-13), pages 1137 - 1143, XP008054746, ISSN: 0755-4982 *
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See also references of WO2004022069A1 *
SEIDMAN M D: "GLUTAMATE ANTAGONISTS, STEROIDS, AND ANTIOXIDANTS AS THERAPEUTIC OPTIONS FOR HEARING LOSS AND TINNITUS AND THE USE OF AN INNER EAR DRUG DELIVERY SYSTEMS", INTERNATIONAL TINNITUS JOURNAL, BAD KISSINGEN, vol. 4, no. 2, 1 January 1998 (1998-01-01), pages 148 - 154, XP009043381, ISSN: 0946-5448 *
THOMSEN JENS ET AL: "Preliminary results of a new delivery system for gentamicin to the inner ear in patients with Meniere's disease", EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, vol. 257, no. 7, August 2000 (2000-08-01), pages 362 - 365, XP002494747, ISSN: 0937-4477 *

Also Published As

Publication number Publication date
EP1545551A1 (en) 2005-06-29
WO2004022069A1 (en) 2004-03-18
AU2009233659A1 (en) 2009-11-26
CA2497867A1 (en) 2004-03-18
AU2002331830A1 (en) 2004-03-29
JP2006502158A (en) 2006-01-19

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Legal Events

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RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE M

Owner name: CHRISTEN, YVES

Owner name: PUJOL, REMY

Owner name: PUEL, JEAN-LUC

Owner name: DURECT CORPORATION

A4 Supplementary search report drawn up and despatched

Effective date: 20080923

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Ipc: A61P 27/16 20060101ALI20080912BHEP

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17Q First examination report despatched

Effective date: 20090210

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