EP1455869A2 - Administration device comprising an expulsion member and a stopper covering - Google Patents

Administration device comprising an expulsion member and a stopper covering

Info

Publication number
EP1455869A2
EP1455869A2 EP20020781046 EP02781046A EP1455869A2 EP 1455869 A2 EP1455869 A2 EP 1455869A2 EP 20020781046 EP20020781046 EP 20020781046 EP 02781046 A EP02781046 A EP 02781046A EP 1455869 A2 EP1455869 A2 EP 1455869A2
Authority
EP
European Patent Office
Prior art keywords
plug
characterized
stopper
surface
delivery device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20020781046
Other languages
German (de)
French (fr)
Inventor
Ulrich Haueter
Hanspeter Heiniger
Erich Imhof
Urs Kipfer
Daniel Peter
Bruno Reihl
Hanspeter Stoller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TecPharma Licensing AG
Original Assignee
TecPharma Licensing AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CH23142001 priority Critical
Priority to CH23142001 priority
Priority to CH612002 priority
Priority to CH612002 priority
Application filed by TecPharma Licensing AG filed Critical TecPharma Licensing AG
Priority to PCT/CH2002/000683 priority patent/WO2003051434A2/en
Publication of EP1455869A2 publication Critical patent/EP1455869A2/en
Application status is Withdrawn legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31513Piston constructions to improve sealing or sliding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31515Connection of piston with piston rod

Abstract

The invention relates to an administration device for dispensing a liquid active-substance solution from an active-substance container (1), said device having a displaceably mounted stopper (2). The administration device comprises an expulsion member (10) for displacing the stopper (2). A contact surface between a surface (5) of the stopper (2) and a front face (4) of the expulsion member (10) or an attachment (12; 13; 14; 16) for the expulsion member (10) is smaller than the surface (5) of the stopper (2). The front face (4) of the expulsion member (10) is preferably uneven for this purpose. The invention also relates to a stopper covering (20) for a stopper (2) of an active-substance container (1), said stopper being displaceable by an expulsion member (10) for administering an active substance from the active-substance container (1). The stopper covering (20) is preferably configured as a sleeve and surrounds the outer surface of the stopper (2) in such a way that an enclosed peripheral area of said outer surface remains free.

Description

Delivery device with the output member and the plug cap

The invention relates to a device for administration, or distribution of an injectable product with an output member and a Wirkstoffbehalter and a plug cap for a plug of the drug container according to the preamble of the independent claims.

In a delivery device as it relates to the invention is, for. B. to dispensers for injection or infusion of a liquid solution of active substance, preferably a liquid medicament, such. B. a solution of insulin or growth hormones. It is preferable that in the dispensing apparatus to portable devices, in particular in the form of so-called injection pens or infusion pumps. Such administration apparatus comprises a Wirkstoffbehalter, in which a liquid solution of active substance is added, which is distributed through an outlet of the container by means of an output member which engages a plug or piston within the active substance container. The following are the terms plug and pistons are used the same sense.

Injection pens as such. Example, from WO 93/16740 are known, as well as pumping equipment as such. Example from EP-B-0143895 are known for infusion or infusion and injection of drug solutions have a housing in which an injectable product in a container, that is added to a drug or drug container. In the container, a piston is slidably received. When moving the piston in the advancing direction towards an outlet of the container to a dose of the product is distributed as a result of displacement by the piston from the container through the outlet. For this purpose, the container, generally fixed an ampoule in the housing such that presses a driven member of a discharge mechanism of the injection pen or the pump device the piston to dispense the product in the feed direction. substantially, the dispensing mechanism comprises at least two elements, the aforementioned driven member, and drive means for the driven member. The driven member protrudes toward the piston into the container when the container is received in the housing. To the driven member, the drive means is engaged such that the driven member is pushed by an operation of the drive means in the advance direction. In known injection pens with spindle drives the drive device is both by turning such. As for the purpose of dosing a distributable with subsequent administration dose of product, and also by Geradverschiebung in the feed direction of the piston, actuated such as by manually exerted pressure. It is also conceivable a dispensing mechanism whose driven member has a sawtooth-like structure, such as a rack, and the drive device is equipped with corresponding counter elements. In known, operatively forming means of electric motors pumping devices with spindle drives the drive means is operated, in general, only by turning, wherein the rotation causes an advance of the driven member.

The liquid solution of active substance is ejected through a patch on the injection pen needle. For this purpose a rear end of the cannula with the drug solution characterized in compound that it protrudes through a pierceable membrane of the container within the injection pen. A front end of the cannula protrudes from the injection pen, and can pierce the skin. For pump devices is a cannula for penetration of the skin at one of the pump opposite end of an infusion line. At the pump end of the infusion tube, a cannula is mounted, which serves for the penetration of the pierceable membrane of the container.

For administration of the drug solution, the needle is first pushed through the skin and then by actuation of the drive means with the release mechanism, this is manual or motorized, the active ingredient solution from the Wirkstoffbehalter through the infusion tube, or through the cannula into the body distributed. The distribution is such that is advanced upon actuation of the dispensing mechanism of the piston by a predetermined path length in the direction of the outlet of the container, whereby the drug solution in the infusion tube, or cannula is displaced.

For safety reasons, such delivery devices are often equipped with pressure or Kraftüberwachungssysthemen to z. B. to an occlusion or leakage between Wirkstoffbehalter, infusion tubing and cannula find such. As described in EP 0,985,419. In the known pressure / force measurements the required force, or the pressure required for advancing the piston is measured in the direction of the outlet of the container or also compared with a reference value ultimately in or derived type. Is an occlusion or leakage is detected, the patient may be by means of an audible or vibratory alert signal over the occlusion or leakage will be informed and a further feed of the output member to be stopped to allow for any further pressure build-up between the piston and cannula, or in case of leakage does not further active ingredient to lose. Both phenomena cause the patient no drug is supplied, which can be particularly dangerous in insulin therapy. When an occlusion is to the risk that a sudden solution to the occlusion too much drug is administered, with serious consequences for the patient.

The disadvantage for the reliable functioning of this pressure / force monitoring systems are established different friction forces in the so-called plug friction of the piston on an inner circumferential surface of the drug container such as a cylindrical vial. These different frictional forces have various causes, such. As longer storage time, temperature effects or different production conditions, such as in the silicone coating of the container inner surface area.

Furthermore, higher frictional forces for increased effort in advance of the piston, which with manually operated devices - especially for weaker patients - can cause that the force required to overcome friction is absent or motorized devices leads to increased energy consumption so that an energy store for the operation of the device, such. As holding a battery, only a short time and therefore has to be replaced more frequently.

In a delivery device having a structure according to the prior art, a Wirkstoffbehalter consists of a cylindrical ampoule, in which a gleitverschiebbarer stopper is arranged, the outer lateral surface dispose with three sealing lips. Opposite the plug an output member of a drive device is arranged, the end face is formed by a planar flange. The three sealing lips serve to minimize the sliding friction and simultaneously seal the vial to the outside, so that emerges during advancement of the plug by means of the output member to an outlet of the ampoule to no drug against the feed direction of the ampoule. For sealing sealing lip is mainly the first, the active substance closest, in charge. The second sealing lip assumes a safety function mainly, while the third sealing lip does not fulfill any essential function. With such a delivery device, a surface of the stopper, which is facing an end face of the output member, and the end surface of flat surfaces is formed which, at the feed of the plug by means of the driven member flat against each other. Here, the technology is essentially covered the entire surface of the plug end face of the output member in the state, creating a large contact area as possible. As a rule, a diameter of a flange of the output member which forms the end face, just large enough so that the flange, the inner surface of the vial, ie the ampoules inner wall, does not quite touch and therefore it does not lead to additional friction.

The invention has for its object to minimize the plug frictional forces as possible, to provide a reliable delivery of a product and a safe handling of a delivery device.

The invention achieves the object by a delivery device of claim 1 and by a stopper cap according to claim 15. Advantageous embodiments of the invention are apparent from the subclaims. Accordingly, in a device for administration or distribution of a liquid active solution of a Wirkstoffbehalter with a displaceably mounted stopper and a driven member for the displacement of the stopper according to the invention, a contact area between a surface of the plug and an end face of the output member or an attachment part of the output member during the displacement of the plug is smaller than the surface of the plug. The end face is then formed by the surface facing the plug. The surface can be formed by the output member itself or an attachment to the driven member. It is also possible that the end surface of surfaces of the driven member and the cap sits together. In this sense, the end surface is to form the contact surface with the displacement of the stopper on the surface of the plug in such a way that a substantial part of said surface not covered or contacted by the end face. The contact surface is therefore smaller than the surface of the plug, preferably it is at least in a ratio of 9: smaller. 7 It is particularly advantageous if the contact surface by more than half the size of the surface.

The advantages achieved by the invention are to be seen essentially in the fact that by the inventive contact area between the output member and plugs occurs a slight deformation of the stopper. That is characterized in that the contact area is smaller than the surface of the stopper bulges or the remaining free area of ​​the surface of the stopper flexes with a feed rate of the output member in the direction of the output member, so that the diameter of the stopper at least in some areas of the lateral surface of the plug slightly smaller is and thereby the friction is reduced on the container wall.

According to one embodiment of the invention, the end face of the output member or the attachment part of the output member is formed uneven. For this purpose, the end face of the output member in the direction of the plug may have in a central region of a bulge or elevation. the surfaces thereof are preferably convex or conically. the end face of the output member, and the attachment part, uneven, such as convex or conically is particularly preferred, and formed the surface of the plug-like plan. However, it is also possible to make the surface of the stopper as described uneven. The end face can then also be planar or non-planar.

It is also possible to provide the end face of the output member in the direction of the plug in an outer region with an annular elevation. Preferably, said annular ridge is formed by a sleeve-shaped element.

In the embodiments described, the end face of the output member or the attachment part of the diameter of the surface, such as a flange supporting the end face, nearly to the inner diameter of the drug container can correspond. However, it should be so much smaller, that no additional friction between the output member or the cap member and the container inner wall is formed, that is slightly smaller than the inner diameter of the container. This can eg. B. a uniform guidance of the output member can be ensured on the stopper and during the advance of the plug, so that the unevenness of the end face of the output member coming zuliegen on the surface of the plug at the desired location, to form the contact surface and ensures a uniform feeding of the piston becomes. However, in principle it is also conceivable to make the diameter of the end surface is smaller than the diameter of the surface according to the invention. Characterized the end face remains in a plane resting on the surface according to the invention still a large part of the surface free.

According to a further embodiment of the invention the end face can be formed by a disc-shaped flange and projecting from this disc. This results in accordance with the invention a small contact area to the surface of the stopper and the flange may provide on the inner wall of the container a necessary guiding of the output member. The diameter of the disc is smaller than the diameter of the disc-shaped flange. In this case, the diameter of the disc-shaped flange depends on the inner diameter of the drug container and the diameter of the disc to the desired size of a contact surface.

In a preferred embodiment of the invention, a Wirkstoffbehalter is selected having a cylindrical shape which is closed by a cylindrical plug. The stopper is at least largely made of elastic material such as an elastomer, that is, when a force acts it can deform and returns without the action of force back into its original shape. Preferably, the plug on its outer circumferential surface is elastic, so that the plug in the region of the lateral surface bend during advancement, or to deform. The cylindrical plug may be for this purpose on its outer lateral surface, one or preferably a plurality of sealing lips which abut at their outer periphery to the inner circumferential surface of the drug container. The surface of the plug facing the driven member is preferably planar, but may comprise a bump, as described above.

The unevenness of the end face of the output member or an attachment part of the driven member is preferably centrally disposed in the center or extending annularly in the circumferential direction by an outer region of the surface. Thereby, a symmetrical force to be guaranteed at the plug during the advance and tilting of the plug can be prevented in the application of force.

Further, the object of the invention by a plug cap for a plug of a drug container which is displaceable for administering a drug from the Wirkstoffbehalter of an output member, is fulfilled, which is preferably sleeve-shaped and according to the invention the plug on its outer circumferential surface surrounding so that a circumferentially a closed portion of the outer surface area remains free. The cap is therefore according to the invention partly inserted between the plug and the inner surface of the drug container. This leaves free a sufficient portion of the plug, which rests all around against the inner lateral surface of the container so that no active substance in the direction of the output member can escape from the container. The plug cap is preferably provided on the plug only before the onset of a drug container or vial in a delivery device. Therefore, during storage of the active substance container outside of the delivery device, the entire outer circumferential surface of the plug to the inner circumferential surface of the drug container located at and provides for a secure seal. Prior to insertion of the drug container into the delivery device, the plug cap is mounted, thus reducing the contact surface of the stopper on the container wall, whereby the frictional forces of the stopper can be reduced to the container wall. For this purpose, the material of the stopper cap on the inner wall of the container has a lower friction than the plug itself, or it remains a small clearance between the container inner wall and the cap outer wall, the plug can be compressed to fit into the cap.

For mounting the sleeve-shaped stopper cap on the stopper, the cap has an edge in the direction of the plug, which extends helically. The cap consists essentially of a sleeve part, that is closed at one side, to which the driven member engages. On the other side, facing the plug, the sleeve part is open and has an edge which points in the direction of the plug. The peripheral surface of the sleeve part parallel to the inner surface of the drug container, the outer diameter of the sleeve is slightly smaller than the inner diameter of the container. According to the invention the edge of the sleeve member is preferably cut in a spiral shape. Characterized applies when mounting the cap on the stopper first point a front edge of the sleeve, or of the spiral on the plug and can be inserted between the plug and the container inner wall. can then be pushed in a simple way, the entire sleeve of the cap over the plug by turning the plug cap. Of course it is also possible to choose other forms for the edge of the sleeve member such. As a jagged shape. When using a stopper cap a portion of the outer surface of the plug of the cap is covered, so that this region contributes less to friction on the container inner wall.

Preferred embodiments of the invention are explained below with reference to the drawing, in this set are:

1 shows a perspective section through a driven member and a

Wirkstoffbehalter with a plug according to the prior art, Figure 2 shows a perspective section through a Wirkstoffbehalter with a

Stopper and a driven member according to a first embodiment of the

Invention, Figure 3a shows a perspective section through a second embodiment of a

Drug container with a stopper and a driven member having a convex part, Figure 3b a perspective view of a cone-shaped component,

4 shows a cross section of a third embodiment of a driven element according to the invention, and Figure 5 is a perspective section through a Wirkstoffbehalter with a

Stopper and a stopper cap according to the present invention.

Figure 1 shows a driven member 10, with an end face mounted plan flange 11 and a rear part of a drug vessel 1 according to the prior art as described above. The Wirkstoffbehalter 1 consists of a cylindrical ampule 1 in which a gleitverschiebbarer plug 2 is housed, the outer lateral surface three sealing lips 3a, 3b and 3c has. A surface 5 of the plug facing the driven member 10 is formed as a planar surface. A front surface 4 of the flange 11 is opposite to the surface 5 of the plug and is also formed planar. The diameter of the end surface 4 is slightly smaller than the diameter of the surface 5. In the feeding of the plug 2 through the output member 10, the front surface 4 is on the surface 5 zuliegen and forms a contact surface, which fills almost the whole surface 5 of the plug. Buckling or bending of the stopper during the advance and thus a reduction of the frictional forces of the stopper 2 on the inner wall of the drug container 1 is therefore not possible.

Figure 2 shows a first embodiment according to the invention in which the size of the contact surface compared to the prior art is significantly reduced. 10 To this end, the output member at its flange 11 in the direction of an attachment part which is designed as a sleeve-shaped component 12th The outer diameter of the flange 11 and the sleeve-shaped component 12 can thereby substantially coincide. The sleeve-shaped member 12 forms an annular ridge of the end face 4 of the driven member, that is, for forming the contact surface is the tubular member 12 only at the edge of the surface 5 of the plug 2, so that the central region of the surface 5 remains largely free and does not contribute to the contact surface , In this embodiment, the drive member is advanced in the advancing direction of the plug 2 10, the surface 5 of the stopper 2 bulges in the sleeve-shaped member 12 and deforming the shape of the plug 2 such that the contact pressure of the stopper 2 is reduced to an inner wall of the ampoule 1 , In this case, the rearmost sealing lip 3c dissolves slightly from the ampoule interior wall, so that the pressing force of the outer circumferential surface of the plug 2 relative to the inner wall of the ampoule 1 relatively decreases and thus the friction during the advance of the plug is reduced. It is not absolutely necessary to use a plug with three sealing lips, which has a relatively large height. It is also possible to provide a small plug of low height, as long as sufficient sealing is effected between the outer surface of the plug and the inner wall of the ampoule. When stopper with a lower height, the bending of the invention, or curvature of the stopper can be particularly effectively utilized, as these are more flexible than plugs with high altitude.

In Figure 3 a shows a second embodiment an uneven face of a driven member is shown. On the flange 11 of the driven member 10 in the direction of an attachment part in the form of a convex component 13 is attached. As an alternative to the convex member 13 and a conical member 14 can be used, as shown in Figure 3b. Is in this embodiment 10 guide form the output member moved in the feed direction of the plug 2, the surface bulges 5 of the stopper 2 to the convex end surface 4 of the component 13, and a tip 15 of the cone-shaped member 14. The surface with which the surface 5 the plug 2 is thereby zuliegen on the convex or conical end surface 4, forms the contact surface according to the invention and is significantly smaller than the entire surface 5 of the plug 2. when the feed of the output member 10, the shape of the stopper 2 is deformed so that the friction between the outer circumferential surface of the plug 2 and the wall of the ampoule 1 decreases. In this case, the rearmost sealing lip 3c can be easily detached from the inner wall of the ampoule. 1

One of ordinary skill will immediately recognize that also differently shaped components at the flange 11 can be arranged to produce a bump according to the invention at the end surface 4 of the driven member 10 or on the surface 5 of the plug. 2 Whereby the plug 2 buckles in an outer region and the sealing lip 10 closest to solve the driven member from the wall of the ampoule. 1

4 shows a third embodiment of the invention is shown. The driven member 10 has a flange 11 which is disc-shaped and on which an additional disk is placed 16th The diameter d2 of the flange 11 is dependent on the inside diameter of the ampoule 1 (not shown). it is preferably between 5 and 15 mm. In an ampoule having an inner diameter 9.6 to 9.8 mm, the diameter d2 is preferably 9 mm. The diameter dl of the disc 16 is smaller than the diameter d2 of the flange 11 and preferably 5 to 10 mm. In an ampoule having an inner diameter 9.6 to 9.8 mm, the diameter dl is preferably 7 mm. The disc 16 and the flange 11 can hl and h2 have different heights. The height h of the disk 16 is preferably 0.5 to 1.0 mm, particularly preferably 0.6 mm. The height h2 of the flange 11 is preferably 0.3 to 0.7 mm, particularly preferably 0.4 mm. Depending on the material of the plug, the ratios of diameter and height of the flange and the disk may be different. Harder plug material causes the diameter dl of the disc 16 is reduced and the height hl of the disc must be maximized 16 to achieve the same camber or bending effect of the plug as it is possible with a soft plug material. Also, the feed force acting on the plug 2 can influence the choice of diameter and height of the components. is also influenced this choice by the stopper design, such as the number of sealing lips, or a different shape. The determined ideal values ​​for a giving plug material such as an elastomer, in an ampoule having an inner diameter 9.6 to 9.8 mm and a plug 2 with three sealing lips 3a, 3b and 3c results in the following Ideal conditions: d2: dl = 9: 7 . For the disc height h and the flange height h2 results ideally a ratio of 6: 4.

The disc 16 or an attachment member such as the components 12, 13 and 14 can be on the output member 10 and the flange 11 are placed and are secured by mechanical connection or by an adhesive, for example. However, it is also conceivable to provide such a component or the disc integral with the drive member 10 or the flange. 11 The sleeve-shaped member 12, the convex member 13, the tapered member 14, the disk-shaped member 16, or a differently shaped member may also be secured directly to the plug 2 or just on the plug. 2 That is, a top part of the driven member 10, which is formed by such a component 5 of the plug 2 may be disposed opposite to or attached and the output member 10 makes, for example, with its flange 11 only for administration of this attachment part prior to administration of the surface. It is also conceivable, the configuration of the surface 5 of the plug 2 in accordance with one of the components described, that is to form as a single or bulge or elevation corresponding to an end surface 4, which is formed by such a component.

In the first, second and third embodiment of the invention, the unevenness of the end face of the driven member 10 or its attachment part, or the choice of the size of the contact area between the surface of the stopper and the end face of the driven member with an appropriate height of the contact effecting component is the cause of minimizing the friction plug. According to a further aspect of the invention, the plug is to be reduced friction by the friction surface of the outer circumferential surface of the plug is reduced to the inner wall of the ampoule. For this, the at least partial enclosure of the plug is provided with a stopper cap, as shown in FIG. 5 The plug cap 20 is formed sleeve-shaped and closed at one end and wraps around the rear portion of the plug 2. A front part 21 of the cap 20 is at its front, that is the edge of the sleeve-shaped cap, spirally formed circumferentially. The front edge of the cap portion 21 therefore falls continuously from a foremost point in the circumferential direction. This spiral-shaped configuration serves to screw the cap 20 into the vial 1 and around the plug. 2 In this case, a tool can be inserted into a notch 22 of the closed cap side at the rear part 25 of the cap 20 and the cap 20 are used in rotation between the plug 2 and the inner wall of the ampoule. 1 Thus, the cap 20 may be arranged in the cartridge 1, the wall of the sleeve-shaped part of the cap must be thin. The outer diameter of the cap 20 is smaller than the inside diameter of the ampoule 1, so that no or only minimal sliding friction between the ampoule 1 and cap 20, and the area covered by the cap plug part consists. Since a inner surface of the cap 20 upon screwing on the stopper 2 can be air-tightly pressed against the outer circumferential surface of the stopper 2, or against one or more sealing lips 3b or 3c of the plug 2, it should be possible, the original between the plug 2 and the cap to vent 20 lying cavity. For this purpose, arranged in the closed rear part 25 of the cap vent holes may be used 24th In order not to impair the tightness of the vial 1, the cap should the second foremost sealing lip 3b are pushed over 20 up to a maximum, so that at least one sealing lip, such as the sealing lip 3a can perform its function of sealing. In any case, it is required for the tightness of the ampoule that is closed in the circumferential direction of the outer circumferential surface of the plug portion of the stopper 2 is not covered by the cap 20th When using a plug cap of the invention, a known face side planes, and equipped with a flat flange driven member for advancing the plug can be used. It is not necessary going to take on the proportions of the mating surfaces particularly into consideration. Furthermore, the following features as belonging to the invention should be considered:

containing 1. A device having a stripping member (10) for administering a liquid Wirkstofϊlösung of a, a displaceably mounted plug (2) medication container (1), characterized in that the contact surface between the plug (2) and driven member (10) (against the plug 2) is uneven.

2. The device according to 1, characterized in that the plug (2) facing the contact surface of the output member (10, 11, 12, 13, 14) for advancing the plug (2) is uneven.

3. The device according to 1, characterized in that the plug (2) facing contact surface of an attachment (11, 12, 13, 14) of the output member (10) for advancing the plug (2) is uneven.

4. A device according to any one of items 1.-3., Characterized in that the unevenness by a sleeve-shaped component (12) is achieved.

5. A device according to any one of items 1.-3., Characterized in that the unevenness by a convex component (13) is achieved.

6. A device according to any one of items 1.-3., Characterized in that the unevenness by a cone-like member (14) is achieved.

7. Device according to one of the preceding items, characterized in that the medicament container as an ampoule (1) is designed.

8. ampoule (1) according to 7, characterized in that the Ampullenauslass is closed by a pierceable membrane.

(Containing 9. The device with the output member (10) for administration of a liquid Wiikstofflösung of a, a displaceably mounted plug (2) medication container (1), characterized in that the diameter (dl) of the plug contact part (16) of the output member is less than 10), than the diameter of the plug (2).

10. The device according to 9, characterized in that the plug (2) contacting part (16) an attachment portion (11, 16) of the output member (10) for advancing the plug (2).

11. Apparatus according to any one of items 9 to 10., Characterized in that the attachment (16) comprises a disc-shaped flange (11) thereof with abragender disc (16).

12. The device according to 11, characterized in that the diameter (dl) of the disc (16) is smaller than the diameter (d2) of the disc-shaped flange (11).

13. The device according to 12, characterized in that the diameter (d2) of the flange (11) is between 5 - 15mm and is the diameter (dl) of the disc (16) is 5 - 10mm.

14. The device according to 13, characterized in that the diameter (d2) is, and the flange (11) 9mm the diameter (dl) of the disc (16) is 7mm

15. Device according to any one of items 9 to 14, characterized in that the height (hl) of the disc (16) is between 0.5 -. 1 mm is.

16. The apparatus according to 15, characterized in that the height (hl) of the disc (16) is 0.6 mm.

17. medicament container (1) for storage of a liquid Wirkstofϊlösung between an outlet and a displaceably mounted in the outlet plug (2), characterized in that the rear stopper part in a sleeve-shaped cap (20) is enclosed.

18, sleeve-shaped cap (20) according to 17, characterized in that the cap (20) partially covering the plug (2) can be screwed.

Bezueszeichenliste

1 Wirkstoffbehalter, ampoule

2 plugs

3a, 3b, 3c sealing lips

4 face

5 surface

10 driven member

11 flange

12 sleeve-shaped component

13 convex component

14 cone-shaped component

15 tip

16 disk-shaped component

20 plug cap

21 front cap portion

22 notch

24 vents

25 rear cap part

Claims

claims
1. A device for administering a liquid drug solution from a Wirkstoffbehalter (1) having a displaceably mounted plug (2), wherein the delivery device comprises a driven member for the displacement of the stopper, characterized in that a contact area between a surface (5) of the plug (2) and an end face (4) of the driven member (10) or an attachment portion (12; 13; 14; 16) of the driven member (10) during the displacement of the stopper (2) is smaller than the surface (5) of the plug ( 2).
2. The delivery device of claim 1, characterized in that the surface (5) of the plug (2) and / or the end face (4) of the driven member (10) or an attachment part of the driven member (10) is uneven.
3. The delivery device of claim 1 or 2, characterized in that the end face (4) in the direction of the plug (2) in a central region of a bulge or elevation.
4. The delivery device according to the preceding claims, characterized in that the end face (4) has a convex or cone-like.
5. The delivery device of claim 1 or 2, characterized in that the end face (4) in the direction of the plug (2) in an outer region of an annular ridge.
6. The delivery device according to the preceding claim, characterized in that the end face (4) is sleeve-shaped.
is 7. The delivery device of any of the preceding claims, characterized in that a diameter of the end face (4) is smaller than a diameter of the surface (5) of the plug (2).
8. The delivery device of any of the preceding claims, characterized in that the end face (4) through a disc-shaped flange (11) and projecting therefrom a disc (16) is formed.
9. Verabreichungsvomchtung according to the preceding claim, characterized in that a diameter (dl) of the smaller disc (16), than a diameter (d2) of the disc-shaped flange (11).
10. The delivery device according to the preceding claim, characterized in that the ratio between the diameter (dl) of the disc (16) and the diameter (d2) of the disc-shaped flange (11) 7: 9.
11. The delivery device of any of the preceding claims, characterized in that the Wirkstoffbehalter (1) is cylindrical and of a cylindrical plug (2) is completed.
12. The delivery device according to the preceding claim, characterized in that the cylindrical plug (2) has at least one sealing lip (3a, 3b, 3c) on its outer circumferential surface which engage with its outer periphery on an inner wall of the active substance container (1).
13. The delivery device of any of the preceding claims, characterized in that the plug (2) at least partially consists of an elastic material.
14. The delivery device of any of the preceding claims, characterized in that the plug (2) is elastic on its outer lateral surface.
15 plug cap (20) for a plug (2) of a drug container (1) which is displaceable for administering a drug from the Wirkstoffbehalter (1) of an output member (10), characterized in that the stopper cap (20) (the plug 2) surrounds such a way on its outer circumferential surface, that a closed circumferential region of the outer circumferential surface of the plug (2) remains free.
16. encloses stopper cap according to claim 15, characterized in that they substantially leaving a front side facing the active area of ​​the stopper (2) and a rear the driven member (10) facing region of the stopper (2).
17 stopper cap according to any one of claims 15 or 16, characterized in that a sleeve-shaped portion of the plug cap (20) has an edge (21) in the direction of the plug (2), which is formed spirally.
EP20020781046 2001-12-19 2002-12-11 Administration device comprising an expulsion member and a stopper covering Withdrawn EP1455869A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CH23142001 2001-12-19
CH23142001 2001-12-19
CH612002 2002-01-16
CH612002 2002-01-16
PCT/CH2002/000683 WO2003051434A2 (en) 2001-12-19 2002-12-11 Administration device comprising an expulsion member and a stopper covering

Publications (1)

Publication Number Publication Date
EP1455869A2 true EP1455869A2 (en) 2004-09-15

Family

ID=25699004

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20020781046 Withdrawn EP1455869A2 (en) 2001-12-19 2002-12-11 Administration device comprising an expulsion member and a stopper covering

Country Status (3)

Country Link
EP (1) EP1455869A2 (en)
AU (1) AU2002349253A1 (en)
WO (1) WO2003051434A2 (en)

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Also Published As

Publication number Publication date
WO2003051434A3 (en) 2003-10-30
WO2003051434A2 (en) 2003-06-26
AU2002349253A1 (en) 2003-06-30

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