EP1429785A4 - Imunogenic conjugate of carbohydrate haptens and aggregated protein carrier - Google Patents

Imunogenic conjugate of carbohydrate haptens and aggregated protein carrier

Info

Publication number
EP1429785A4
EP1429785A4 EP02750420A EP02750420A EP1429785A4 EP 1429785 A4 EP1429785 A4 EP 1429785A4 EP 02750420 A EP02750420 A EP 02750420A EP 02750420 A EP02750420 A EP 02750420A EP 1429785 A4 EP1429785 A4 EP 1429785A4
Authority
EP
European Patent Office
Prior art keywords
imunogenic
conjugate
protein carrier
aggregated protein
carbohydrate haptens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02750420A
Other languages
German (de)
French (fr)
Other versions
EP1429785A1 (en
Inventor
Mark J Krantz
B Michael Longenecker
R Rao Koganty
Ting Chi Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncothyreon Canada Inc
Original Assignee
Biomira Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomira Inc filed Critical Biomira Inc
Publication of EP1429785A1 publication Critical patent/EP1429785A1/en
Publication of EP1429785A4 publication Critical patent/EP1429785A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/001172—Sialyl-Thomson-nouvelle antigen [sTn]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
EP02750420A 2001-08-14 2002-08-05 Imunogenic conjugate of carbohydrate haptens and aggregated protein carrier Withdrawn EP1429785A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31185001P 2001-08-14 2001-08-14
US311850P 2001-08-14
PCT/US2002/024735 WO2003015796A1 (en) 2001-08-14 2002-08-05 Imunogenic conjugate of carbohydrate haptens and aggregated protein carrier

Publications (2)

Publication Number Publication Date
EP1429785A1 EP1429785A1 (en) 2004-06-23
EP1429785A4 true EP1429785A4 (en) 2005-12-14

Family

ID=23208785

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02750420A Withdrawn EP1429785A4 (en) 2001-08-14 2002-08-05 Imunogenic conjugate of carbohydrate haptens and aggregated protein carrier

Country Status (6)

Country Link
US (1) US20040247608A1 (en)
EP (1) EP1429785A4 (en)
JP (1) JP2005526692A (en)
CN (1) CN1543350A (en)
CA (1) CA2454853A1 (en)
WO (1) WO2003015796A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037261A1 (en) * 2003-10-14 2005-04-28 Biomira, Inc. Combination therapy for cancer
CN102276662B (en) * 2010-06-09 2014-05-14 北京大学 Sialic acid (alpha-(2-6))-D-pyranose derivative and its synthetic method and use
CN105764921B (en) * 2013-09-17 2020-06-30 台湾浩鼎生技股份有限公司 Carbohydrate vaccine compositions for inducing immune response and use thereof for treating cancer
SG11201702037SA (en) * 2014-09-15 2017-04-27 Obi Pharma Inc Immunogenic/therapeutic glycoconjugate compositions and uses thereof
EP3344806A4 (en) 2015-09-04 2019-03-20 OBI Pharma, Inc. Glycan arrays and method of use
KR20180121786A (en) 2016-03-29 2018-11-08 오비아이 파머 인코퍼레이티드 Antibodies, pharmaceutical compositions and methods
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
EP3445395A4 (en) 2016-04-22 2019-12-25 OBI Pharma, Inc. Cancer immunotherapy by immune activation or immune modulation via globo series antigens
BR112019001656A2 (en) 2016-07-27 2019-05-28 Obi Pharma Inc composition, pharmaceutical composition, vaccine, method for inducing antibodies in an individual, method for treating cancer in a patient in need thereof and method for inducing or ameliorating the immune reaction in an individual in need thereof
EP3491026A4 (en) 2016-07-29 2020-07-29 OBI Pharma, Inc. Human antibodies, pharmaceutical compositions and methods
CN106526188A (en) * 2016-11-09 2017-03-22 百奥森（江苏）食品安全科技有限公司 Detection kit for salbutamol in foods
CN106645697A (en) * 2016-11-09 2017-05-10 百奥森（江苏）食品安全科技有限公司 A kit for detecting zeranol in foods
CA3044274A1 (en) 2016-11-21 2018-05-24 Obi Pharma, Inc. Conjugated biological molecules, pharmaceutical compositions and methods
WO2020006176A1 (en) 2018-06-27 2020-01-02 Obi Pharma, Inc. Glycosynthase variants for glycoprotein engineering and methods of use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029927A2 (en) * 1994-05-02 1995-11-09 Biomira, Inc. Process for preparation of glycosides of tumor-associated carbohydrate antigens
WO1999048515A1 (en) * 1998-03-25 1999-09-30 Sloan-Kettering Institute For Cancer Research Trimeric antigenic o-linked glycopeptide conjugates, methods of preparation and uses thereof
US5981476A (en) * 1993-04-19 1999-11-09 Perimmune Holdings, Inc. Method for treating bladder cancer with a keyhole limpet hemocyanin composition having enhanced anti-tumor activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2247095A (en) * 1994-04-12 1995-10-30 Biomira Inc. Cellular immune response-specific antigens and uses therefor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981476A (en) * 1993-04-19 1999-11-09 Perimmune Holdings, Inc. Method for treating bladder cancer with a keyhole limpet hemocyanin composition having enhanced anti-tumor activity
WO1995029927A2 (en) * 1994-05-02 1995-11-09 Biomira, Inc. Process for preparation of glycosides of tumor-associated carbohydrate antigens
WO1999048515A1 (en) * 1998-03-25 1999-09-30 Sloan-Kettering Institute For Cancer Research Trimeric antigenic o-linked glycopeptide conjugates, methods of preparation and uses thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HELLING F ET AL: "G(D3) vaccines for melanoma: Superior immunogenicity of keyhole limpet hemocyanin conjugate vaccines", CANCER RESEARCH 1994 UNITED STATES, vol. 54, no. 1, 1994, pages 197 - 203, XP002934626, ISSN: 0008-5472 *
HELLING FRIEDHELM ET AL: "G-M2-KLH conjugate vaccine: Increased immunogenicity in melanoma patients after administration with immunological adjuvant QS-21", CANCER RESEARCH, vol. 55, no. 13, 1995, pages 2783 - 2788, XP001207708, ISSN: 0008-5472 *
MORSE M A: "TECHNOLOGY EVALUATION: THERATOPE", CURRENT OPINION IN MOLECULAR THERAPEUTICS, CURRENT DRUGS, LONDON,, GB, vol. 2, no. 4, August 2000 (2000-08-01), pages 453 - 458, XP009015388, ISSN: 1464-8431 *
RAGUPATHI G ET AL: "Vaccines prepared with sialyl-Tn and sialyl-Tn trimers using the 4-(4-maleimidomethyl)cyclohexane-1-carboxyl hydrazide linker group result in optimal antibody titers against ovine submaxillary mucin and sialyl-Tn-positive tumor cells", CANCER IMMUNOLOGY AND IMMUNOTHERAPY, BERLIN, DE, vol. 48, no. 1, April 1999 (1999-04-01), pages 1 - 8, XP002328001, ISSN: 0340-7004 *
See also references of WO03015796A1 *

Also Published As

Publication number Publication date
US20040247608A1 (en) 2004-12-09
CA2454853A1 (en) 2003-02-27
WO2003015796A1 (en) 2003-02-27
CN1543350A (en) 2004-11-03
EP1429785A1 (en) 2004-06-23
JP2005526692A (en) 2005-09-08

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20040315

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

A4 Supplementary search report drawn up and despatched

Effective date: 20051102

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20071020