EP1271610A3 - Mass spectrometer - Google Patents

Mass spectrometer Download PDF

Info

Publication number
EP1271610A3
EP1271610A3 EP02254394A EP02254394A EP1271610A3 EP 1271610 A3 EP1271610 A3 EP 1271610A3 EP 02254394 A EP02254394 A EP 02254394A EP 02254394 A EP02254394 A EP 02254394A EP 1271610 A3 EP1271610 A3 EP 1271610A3
Authority
EP
European Patent Office
Prior art keywords
mass spectrometer
ions
fragmentation cell
apertures
gradient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP02254394A
Other languages
German (de)
French (fr)
Other versions
EP1271610B1 (en
EP1271610A2 (en
Inventor
Robert Harold Bateman
Kevin Giles
Steve Pringle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0115429A external-priority patent/GB0115429D0/en
Priority claimed from GB0120122A external-priority patent/GB0120122D0/en
Priority claimed from GB0206164A external-priority patent/GB0206164D0/en
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Priority to EP04026519A priority Critical patent/EP1505634B1/en
Publication of EP1271610A2 publication Critical patent/EP1271610A2/en
Publication of EP1271610A3 publication Critical patent/EP1271610A3/en
Application granted granted Critical
Publication of EP1271610B1 publication Critical patent/EP1271610B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/065—Ion guides having stacked electrodes, e.g. ring stack, plate stack
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/005—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field

Abstract

A mass spectrometer is disclosed comprising a fragmentation cell 1 comprised of a plurality of ring or plate-like electrodes having apertures through which ions are transmitted. An axial DC gradient is preferably maintained along at least a portion of the length of the fragmentation cell 1 in order to improve the transit time of ions through the device.
EP02254394.6A 2001-06-25 2002-06-24 Mass spectrometer Expired - Lifetime EP1271610B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04026519A EP1505634B1 (en) 2001-06-25 2002-06-24 Mass spectrometer

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB0115429A GB0115429D0 (en) 2001-06-25 2001-06-25 Mass spectrometers and methods of mass spectrometry
GB0115429 2001-06-25
GB0120122A GB0120122D0 (en) 2001-06-25 2001-08-17 Gas collision cell
GB0120096A GB0120096D0 (en) 2001-06-25 2001-08-17 Mass spectrometers and methods of mass spectrometry
GB0120096 2001-08-17
GB0120122 2001-08-17
GB0206164A GB0206164D0 (en) 2001-06-25 2002-03-15 Mass spectrometer
GB0206164 2002-03-15

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP04026519A Division EP1505634B1 (en) 2001-06-25 2002-06-24 Mass spectrometer
EP04026519A Division-Into EP1505634B1 (en) 2001-06-25 2002-06-24 Mass spectrometer

Publications (3)

Publication Number Publication Date
EP1271610A2 EP1271610A2 (en) 2003-01-02
EP1271610A3 true EP1271610A3 (en) 2004-10-13
EP1271610B1 EP1271610B1 (en) 2017-12-27

Family

ID=27447962

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02254394.6A Expired - Lifetime EP1271610B1 (en) 2001-06-25 2002-06-24 Mass spectrometer

Country Status (3)

Country Link
EP (1) EP1271610B1 (en)
CA (1) CA2391148C (en)
GB (1) GB2381949C (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60316070T2 (en) * 2002-05-30 2008-06-05 Micromass Uk Ltd. mass spectrometry
US6800846B2 (en) 2002-05-30 2004-10-05 Micromass Uk Limited Mass spectrometer
GB2394356B (en) * 2002-08-05 2005-02-16 Micromass Ltd Mass spectrometer
US7071467B2 (en) 2002-08-05 2006-07-04 Micromass Uk Limited Mass spectrometer
US8866073B2 (en) 2013-03-15 2014-10-21 Morpho Detection, Llc Ion trap mobility spectrometer and method of using the same
US9147565B1 (en) 2014-12-30 2015-09-29 Morpho Detection, Llc Ion mobility spectrometer and method of using the same
WO2023237958A1 (en) * 2022-06-09 2023-12-14 Dh Technologies Development Pte. Ltd. Rf choke for use in a mass spectrometer and rf choke

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6111250A (en) * 1995-08-11 2000-08-29 Mds Health Group Limited Quadrupole with axial DC field

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814613A (en) * 1987-03-06 1989-03-21 Extrel Corporation Collision cell for triple quadrupole tandem mass spectrometry
US5206506A (en) * 1991-02-12 1993-04-27 Kirchner Nicholas J Ion processing: control and analysis
DE19523859C2 (en) * 1995-06-30 2000-04-27 Bruker Daltonik Gmbh Device for reflecting charged particles
DE19628179C2 (en) * 1996-07-12 1998-04-23 Bruker Franzen Analytik Gmbh Device and method for injecting ions into an ion trap
US6107628A (en) * 1998-06-03 2000-08-22 Battelle Memorial Institute Method and apparatus for directing ions and other charged particles generated at near atmospheric pressures into a region under vacuum
GB2375653B (en) * 2001-02-22 2004-11-10 Bruker Daltonik Gmbh Travelling field for packaging ion beams
CA2391060C (en) * 2001-06-21 2011-08-09 Micromass Limited Mass spectrometer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6111250A (en) * 1995-08-11 2000-08-29 Mds Health Group Limited Quadrupole with axial DC field

Also Published As

Publication number Publication date
GB2381949A (en) 2003-05-14
EP1271610B1 (en) 2017-12-27
GB2381949B (en) 2004-01-07
GB2381949C (en) 2006-02-06
CA2391148A1 (en) 2002-12-25
EP1271610A2 (en) 2003-01-02
GB0214583D0 (en) 2002-08-07
CA2391148C (en) 2008-02-19

Similar Documents

Publication Publication Date Title
EP1271608A3 (en) Mass spectrometer
EP1215712A3 (en) Mass spectrometer and methods of mass spectrometry
AU2002367466A1 (en) Amplification of nucleic acid fragments using nicking agents
WO2002090539A3 (en) Compositions, methods, and kits for isolating nucleic acids using surfactants and proteases
MXPA05013658A (en) Stabilized immunomodulatory oligonucleotides.
EP1211507A3 (en) Nucleic acid detection sensor
JP2003515656A5 (en)
EP1510180A3 (en) Steerable loop structure
EP1348473A3 (en) Set of elements for assembling structures
WO2003066802A3 (en) Gene expression analysis using nicking agents
WO2002069369A3 (en) Cpg-like nucleic acids and methods of use thereof
WO2002026968A3 (en) Antisense iap nucleic acids and uses thereof
EP1271784A3 (en) PLD architecture for flexible placement of IP function blocks
DE60213803D1 (en) Happier mapping
EP0957218A3 (en) Spacer between pole and cross-arm
BR0210544A (en) Nucleic Acid Multiplex Formation
EP0989586A3 (en) A method and apparatus for transferring ions from an atmospheric pressure ion source into an ion trap mass spectrometer
MXPA03007535A (en) Method of extracting virus from cell culture.
EP1271610A3 (en) Mass spectrometer
WO2002040042A3 (en) Method for optimally delivering virus to a solid tumor mass
AU5626900A (en) The high bone mass gene of 11q13.3
AU2003247651A1 (en) PREPARATION OF STEREOISOMERS OF (3ALPHA, 3ALPHA/BETA, 6ALPHA/BETA) HEXAHYDROFURO(2,3-b)FURAN-3-OL
EP1505634A3 (en) Mass spectrometer
EP1235242A3 (en) Multi-pole switch device
EP1089601A3 (en) Magnetically deflected arc lamp

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MICROMASS UK LIMITED

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

17P Request for examination filed

Effective date: 20050401

AKX Designation fees paid

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 60249234

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: H01J0049420000

Ipc: H01J0049000000

RIC1 Information provided on ipc code assigned before grant

Ipc: H01J 49/06 20060101ALI20120116BHEP

Ipc: H01J 49/00 20060101AFI20120116BHEP

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MICROMASS UK LIMITED

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

INTG Intention to grant announced

Effective date: 20170929

RBV Designated contracting states (corrected)

Designated state(s): AT BE CH CY DE DK ES FI FR GR IE IT LI LU MC NL PT SE TR

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH CY DE DK ES FI FR GR IE IT LI LU MC NL PT SE TR

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 958982

Country of ref document: AT

Kind code of ref document: T

Effective date: 20180115

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 60249234

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20171227

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20171227

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 958982

Country of ref document: AT

Kind code of ref document: T

Effective date: 20171227

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180328

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 17

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20171227

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20171227

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20171227

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20171227

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20171227

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 60249234

Country of ref document: DE

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20171227

26N No opposition filed

Effective date: 20180928

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20180630

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20171227

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180624

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180624

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180630

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180630

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180630

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20190522

Year of fee payment: 18

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20171227

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20171227

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200630

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20210519

Year of fee payment: 20

REG Reference to a national code

Ref country code: DE

Ref legal event code: R071

Ref document number: 60249234

Country of ref document: DE