EP1218404A4 - A binding motif of a receptor - Google Patents

A binding motif of a receptor

Info

Publication number
EP1218404A4
EP1218404A4 EP00963808A EP00963808A EP1218404A4 EP 1218404 A4 EP1218404 A4 EP 1218404A4 EP 00963808 A EP00963808 A EP 00963808A EP 00963808 A EP00963808 A EP 00963808A EP 1218404 A4 EP1218404 A4 EP 1218404A4
Authority
EP
European Patent Office
Prior art keywords
receptor
binding motif
motif
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00963808A
Other languages
German (de)
French (fr)
Other versions
EP1218404A1 (en
Inventor
Mark Andrew Guthridge
Frank Charles Stomski
Angel Francisco Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medvet Science Pty Ltd
Original Assignee
Medvet Science Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPQ2875A external-priority patent/AUPQ287599A0/en
Priority claimed from AUPQ8733A external-priority patent/AUPQ873300A0/en
Application filed by Medvet Science Pty Ltd filed Critical Medvet Science Pty Ltd
Publication of EP1218404A1 publication Critical patent/EP1218404A1/en
Publication of EP1218404A4 publication Critical patent/EP1218404A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP00963808A 1999-09-15 2000-09-15 A binding motif of a receptor Withdrawn EP1218404A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPQ287599 1999-09-15
AUPQ2875A AUPQ287599A0 (en) 1999-09-15 1999-09-15 A binding motif of a receptor
AUPQ8733A AUPQ873300A0 (en) 2000-07-12 2000-07-12 A binding motif of a receptor (2)
AUPQ873300 2000-07-12
PCT/AU2000/001118 WO2001019847A1 (en) 1999-09-15 2000-09-15 A binding motif of a receptor

Publications (2)

Publication Number Publication Date
EP1218404A1 EP1218404A1 (en) 2002-07-03
EP1218404A4 true EP1218404A4 (en) 2004-04-07

Family

ID=25646144

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00963808A Withdrawn EP1218404A4 (en) 1999-09-15 2000-09-15 A binding motif of a receptor

Country Status (2)

Country Link
EP (1) EP1218404A4 (en)
WO (1) WO2001019847A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670150B1 (en) * 2001-05-10 2003-12-30 Applera Corporation Isolated human receptor proteins, nucleic acid molecules encoding human receptor proteins, and uses thereof
US20140047572A1 (en) * 2012-08-13 2014-02-13 University Of Rochester Thrombopoietin mimetics for the treatment of radiation or chemical induced bone marrow injury

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001788A1 (en) * 1990-07-18 1992-02-06 Schering Corporation Beta chain of the human gm-csf receptor and uses thereof
US5677144A (en) * 1993-11-16 1997-10-14 Ullrich; Axel Recombinant DNA encoding CCK 2, a receptor tyrosine kinase
WO1997048728A1 (en) * 1996-06-20 1997-12-24 Koster, Henk, Wilhelmus Il-6 and il-6-receptor derived peptides having il-6 antagonistic or agonistic activity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001788A1 (en) * 1990-07-18 1992-02-06 Schering Corporation Beta chain of the human gm-csf receptor and uses thereof
US5677144A (en) * 1993-11-16 1997-10-14 Ullrich; Axel Recombinant DNA encoding CCK 2, a receptor tyrosine kinase
WO1997048728A1 (en) * 1996-06-20 1997-12-24 Koster, Henk, Wilhelmus Il-6 and il-6-receptor derived peptides having il-6 antagonistic or agonistic activity

Non-Patent Citations (29)

* Cited by examiner, † Cited by third party
Title
BAGLEY C J ET AL: "THE STRUCTURAL AND FUNCTIONAL BASIS OF CYTOKINE RECEPTOR ACTIVATION: LESSONS FROM THE COMM BETA SUBUNIT OF THE GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR, INTERLEUKINS-3 (IL-3), AND IL-5 RECEPTORS", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 89, no. 5, 1 March 1997 (1997-03-01), pages 1471 - 1482, XP001052641, ISSN: 0006-4971 *
BONNEFOY-BERARD NATHALIE ET AL: "Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 92, no. 22, 1995, 1995, pages 10142 - 10146, XP002267718, ISSN: 0027-8424 *
DARNAY B G ET AL: "The p80TNF receptor-associated kinase (p80TRAK) associates with residues 354-397 of the p80 cytoplasmic domain: similarity to casein kinase", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 406, no. 1-2, 7 April 1997 (1997-04-07), pages 101 - 105, XP004261192, ISSN: 0014-5793 *
DATABASE SWISSPROT [online] 1 November 1997 (1997-11-01), XP002267725, accession no. EBI Database accession no. Q16832 *
DATABASE SWISSPROT [online] 1 October 1993 (1993-10-01), XP002238516, accession no. EBI Database accession no. p32927 *
DATABASE UNIPROT [online] 1 February 1995 (1995-02-01), XP002267721, accession no. EBI Database accession no. P40189 *
DATABASE UNIPROT [online] 1 February 1995 (1995-02-01), XP002267723, accession no. EBI Database accession no. P20333 *
DATABASE UNIPROT [online] 1 February 1996 (1996-02-01), XP002267722, accession no. EBI Database accession no. P48357 *
DATABASE UNIPROT [online] 1 November 1990 (1990-11-01), XP002267724, accession no. EBI Database accession no. P17948 *
DE GROOT ROLF P ET AL: "Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family.", CELLULAR SIGNALLING, vol. 10, no. 9, October 1998 (1998-10-01), pages 619 - 628, XP002238512, ISSN: 0898-6568 *
GERBER HANS-PETER ET AL: "Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway: Requirement for Flk-1/KDR activation", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 46, 13 November 1998 (1998-11-13), pages 30336 - 30343, XP002155564, ISSN: 0021-9258 *
GONDA THOMAS J ET AL: "Activating mutations in cytokine receptors: Implications for receptor function and role in disease.", BLOOD, vol. 89, no. 2, 1997, pages 355 - 369, XP002238511, ISSN: 0006-4971 *
HIBI M ET AL: "MOLECULAR CLONING AND EXPRESSION OF AN IL-6 SIGNAL TRANSDUCER, GP130", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 63, 21 December 1990 (1990-12-21), pages 1149 - 1157, XP001073990, ISSN: 0092-8674 *
JUCKER MANFRED ET AL: "Identification of a new adapter protein that may link the common beta subunit of the receptor for granulocyte/macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 to phosphatidylinositol 3-kinase.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 46, 1995, pages 27817 - 27822, XP002238513, ISSN: 0021-9258 *
KARN T ET AL: "STRUCTURE, EXPRESSION AND CHROMOSOMAL MAPPING OF TKT FROM MAN AND MOUSE: A NEW SUBCLASS OF RECEPTOR TYROSINE KINASES WITH A FACTOR VIII-LIKE DOMAIN", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 8, no. 12, 1 December 1993 (1993-12-01), pages 3433 - 3440, XP000471876, ISSN: 0950-9232 *
LI CAI ET AL: "Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, no. 17, 17 August 1999 (1999-08-17), pages 9677 - 9682, XP002185670, ISSN: 0027-8424 *
LIU Y-C ET AL: "Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 15, 11 April 1997 (1997-04-11), pages 9979 - 9985, XP002089346, ISSN: 0021-9258 *
MASIAKOWSKI PIOTR ET AL: "A novel family of cell surface receptors with tyrosine kinase-like domain", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 36, 1992, pages 26181 - 26190, XP002267720, ISSN: 0021-9258 *
MURAKAMI M ET AL: "Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 88, December 1991 (1991-12-01), pages 11349 - 11353, XP002954109, ISSN: 0027-8424 *
MUSLIN A J ET AL: "Interaction of 14-3-3 with signaling proteins is mediatd by the recognition of phosphoserine", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 84, 22 March 1996 (1996-03-22), pages 889 - 897, XP002089347, ISSN: 0092-8674 *
NG PATRICK W P ET AL: "Mutations which abolish phosphorylation of the TRAF-binding domain of TNF receptor 2 enhance receptor-mediated NF-kappaB activation", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 244, no. 3, 27 March 1998 (1998-03-27), pages 756 - 762, XP002267719, ISSN: 0006-291X *
SAKAMAKI K ET AL: "CRITICAL CYTOPLASMIC DOMAINS OF THE COMMON BETA SUBUNIT OF THE HUMAN GM-CSF, IL-3 AND IL-5 RECEPTORS FOR GROWTH SIGNAL TRANSDUCTION AND TYROSINE PHOSPHORYLATION", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 11, no. 10, 1992, pages 3541 - 3549, XP002070273, ISSN: 0261-4189 *
See also references of WO0119847A1 *
SHIBUYA M ET AL: "NUCLEOTIDE SEQUENCE AND EXPRESSION OF A NOVEL HUMAN RECEPTOR-TYPE, TYROSINE KINASE GENE (FLT) CLOSELY RELATED TO THE FMS FAMILY", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 5, 1990, pages 519 - 524, XP000569874, ISSN: 0950-9232 *
SMITH ALISON ET AL: "Cytoplasmic domains of the common beta-chain of the GM-CSF/IL-3/IL-5 receptors that are required for inducing differentiation or clonal suppression in myeloid leukaemic cell lines.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 16, no. 3, 1997, pages 451 - 464, XP002238514, ISSN: 0261-4189 *
SMITH C A ET AL: "A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 248, 25 May 1990 (1990-05-25), pages 1019 - 1022-1023, XP002107350, ISSN: 0036-8075 *
SUN Q ET AL: "Simultaneous antagonism of interleukin-5, granulocyte-macrophage colony-stimulating factor, and interleukin-3 stimulation of human eosinophils by targetting the common cytokine binding site of their receptors.", BLOOD, vol. 94, no. 6, pages 1943 - 1951, XP002238515, ISSN: 0006-4971 *
TARTAGLIA L A ET AL: "IDENTIFICATION AND EXPRESSION CLONING OF A LEPTIN RECEPTOR, OB-R", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 83, no. 7, 29 December 1995 (1995-12-29), pages 1263 - 1271, XP000602068, ISSN: 0092-8674 *
ZHANG SHAO-HUI ET AL: "Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3-beta protein", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 43, 1997, pages 27281 - 27287, XP002267717, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2001019847A1 (en) 2001-03-22
EP1218404A1 (en) 2002-07-03

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Ipc: 7C 07K 14/71 B

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