EP1212365A2 - Crystal structures of domains of receptor protein tyrosine kinases and their ligands - Google Patents

Abstract

The determination and use of three dimensional structures of receptor protein tyrosine kinases and/or their ligands are described. One particular group of such structures includes three dimensional structures of the extracellular domain of RPTKs. The three dimensional structures of RPTKs can faciliate the design and identification of modulators of RPTK function. Other such structures can include of RPTK ligands, such as stem cell factor or a fragment thereof. Modulators of RPTK function can be used to treat diseases that are mediated by inappropriate RPTK activity.

Description

CRYSTAL STRUCTURES OF DOMAINS OF RECEPTOR PROTEIN TYROSINE

KINASES AND THEIR LIGANDS

Background The following description ofthe background ofthe invention is provided simply as an aid in understanding the invention and is not admitted to describe or constitute prior art to the invention.

Receptor protein tyrosine kinases ("RPTKs") include a large and diverse family of enzymes. The RPTK family contains multiple subfamilies, one of which is the fibroblast growth factor receptor (FGFR) subfamily. Another subfamily is the type III receptor tyrosine kinase (RTK) subfamily whose members include platelet-derived growth factor receptors α and β ("PDGFR α" and "PDGFR β"), macrophage colony-stimulating factor receptor (M- CSFR), c-kit (also referred to as SCF receptor ("SCFR")) and i eflt3 receptor. The members of this RTK subfamily contain five immunoglobulin-like (Ig) domains in their extracelllular ligand binding domains followed by a single transmembrane domain and a cytoplasmic tyrosine kinase domain interrupted by a large kinase-insert. For a review of RPTKs, see Schlessinger and Ullrich, 1992, Neuron 9: 383-391; for a review describing the FGFR subfamily, see Givol and Yayon, 1992, FASEBJ. 6 (15): 3362-3369.

All RPTKs enzymatically transfer a high energy phosphate from adenosine triphosphate to a tyrosine residue in a target protein. These phosphorylation events regulate certain cellular phenomena in signal transduction processes. Cellular signal transduction processes contain multiple steps that convert an extracellular signal into an intracellular signal. The intracellular signal is then converted into a cellular response. RPTKs are components in many signal transduction processes. Typically, an RPTK regulates the flow of a signal in a particular step in the process by phosphorylating a downstream molecule. This phosphorylation modulates the downstream molecule's activity by turning it either "on" or "off," causing excessive or deficient signalling by the downstream molecule. Excessive signalling can lead to such abnormalities as uncontrolled cell proliferation, which is characteristic of such disorders as cancer, angiogenesis induced by various tumors, atherosclerosis, and arthritis. Alternatively, cellular proliferation can be induced therapeutically, for example angiogenesis may be used to ameliorate coronary artery disease by inducing collateral vascularization.

Ligand-induced dimerization of RPTKs is an important step in the RPTK-mediated signal transduction process. For review ofthe importance of dimerization of RPTKs, see Lemmon and Schlessenger, 1994, Trends in Biochem. Sci. 19: 459-463; and Ullrich and Schlessenger, 1990, Cell 61:203-212. Some growth factors, for example platelet-derived growth factor ("PDGF") and stem cell factor ("SCF"), are dimeric molecules that, by themselves, induce dimerization of their specific receptors. In contrast, other growth factors, such as fibroblast growth factors (FGFs), are monomeric molecules that must act in concert with other molecules to induce dimerization of their specific receptors. See Schlessenger et al, 1995, Cell 83: 357-360; Spivak-Kroizman et al, 1994, Cell 79: 1015-1024; Ornitz et al, 1992, Mol. Cell. Biol. 12: 240-247. In particular, FGFs typically function in concert with soluble or cell surface-bound heparin sulfate-containing proteoglycans (HSPGs).

The FGFR subfamily consists of at least 21 structurally related polypeptides, designated FGFR1 through FGFR21 , that are expressed in embryonic, fetal, and adult vertebrates. FGFR1 through FGFR4, are known as "high affinity FGFRs," due to their ability to bind appropriate fibroblast growth factors with a high affinity. These high affinity FGFRs are characterized by an extracellular ligand-binding domain which comprises three immunoglobulin (IG)-like domains (known as Dl, D2, and D3), a single transmembrane helix, and a cytoplasmic domain containing tyrosine kinase activity. See Lee et ah, 1989,

Science 245: 57-60; Jaye et al, 1992, J. Mol. Biol. 227: 840-851; Johnson & Williams, 1993, Adv. Cancer. Res. 60: 1-41. Each ofthe four high affinity FGFRs binds to a specific subset of FGFs. Ornitz et al, 1996, J Biol. Chem. 271: 15292-15297.

Naturally occuring variants ofthe high affinity FGFRs lacking Dl, or Dl and the linker region between Dl and D2 known as the "acid box," have been identified. These varient FGFRs retain the ability to bind appropriate FGFs with high affinity, suggesting that the D2 and D3 regions are sufficient to confer FGF binding ability and specificity. See Crumley etal, 1991, Oncogene 6: 2255-2262; Dionne et al, 1990, EMBOJ. 9: 2685-2692; Johnson and Williams, 1993, Adv. Cancer. Res. 60: 1-41. In particular, D3 has been shown to play a critical role in the binding specificity of FGFRs. See Bottaro, et al, 1990, J. Biol. Chem. 265: 12767-12770; Miki et al, 1992, Proc. Natl. Acad. Sci. 89: 246-250; Dell et al, 1992, J Biol. Chem. 267: 21225-21229; Yayon etal, 1992 EMBOJ. 11: 1885-1890. Recently, three dimensional structures ofthe intracellular catalytic domains of various PTKs have been described in International Publication No. WO 98/07835, U.S. Patent Application Serial No. 60/034,168, filed December 19, 1996, and U.S. Patent No. 5,942,428, issued on August 24, 1999, each of which is hereby incorporated herein by reference in its entirety including all claims, drawings, tables, and figures.

Despite recent advances in the understanding of signal transduction and function of the receptor PTKs and their ligands, there remains a need in the art for the atomic-level characterization and analysis of such molecules, particularly with respect to the design and synthesis of novel and improved therapeutic molecules.

Summary

The present invention relates to the three dimensional structures of receptor protein tyrosine kinases and/or their ligands. These molecular structures may include an RPTK or ligand thereof, alone or as a complex including one or more ligands. In particular, this application relates to molecular structures comprising a polypeptide which includes the extracellular domain of a receptor protein tyrosine kinase, alone and in complexes comprising one or more ligands. In another aspect, the application describes molecular structures comprising a polypeptide which includes the receptor binding core of a growth factor, such as stem cell facter, alone or in a complex with one or more ligands such as a receptor protein tyrosine kinase. The present application concerns solving and using the three dimensional structures of receptor protein tyrosine kinases, and more particularly to structures including the extracellular domain of receptor protein tyrosine kinases, alone and in complexes comprising one or more ligands. As an example, X-ray crystallograpic techniques are used herein to determine the three dimensional structure of certain RPTK extracellular domains bound to certain ligands, such as FGF molecules or SCF molecules, at atomic resolution. The application also concerns solving and using the three dimensional structures of stem cell factor, and more particularly to structures including the receptor binding core of stem cell factor, alone and in complexes comprising one or more ligands.

The three dimensional structures described herein elucidate specific interactions between receptor protein tyrosine kinases and/or ligands bound to them. The coordinates that define the three dimensional structures of receptor protein tyrosine kinases are useful for determining three dimensional structures of receptor RPTKs with unknown structure. In addition, the coordinates are also useful for designing and identifying modulators of receptor protein tyrosine kinase function. These modulators are potentially useful as therapeutics for treating or preventing disease, including (but not limited to) cell proliferative diseases, such as cancer, tumorigenic angiogenesis, atherosclerosis, and arthritis. Altematively, cellular proliferation can be induced therapeutically, for example angiogenesis may be used to ameliorate coronary artery disease by inducing collateral vascularization. Thus in a first aspect, the invention features a crystalline form of a polypeptide corresponding to all or a portion ofthe extracellular domain of an RPTK. In certain embodiments, the invention features a crystalline form of an RPTK bound to a ligand or ligand analog. In typical embodiments, the RPTK is an FGFR, such as FGFR1 or FGFR2, and the ligand is an FGF, such as FGF1 or FGF2. In particularly suitable embodiments, the polypeptide comprises residues 150-360 of FGFR1 or residues 150-360 of FGFR2, the sequences of which are shown in Figure 4. The ligand can be a fibroblast growth factor, such as an FGF1 including the amino acid sequence as shown in Figure 17 or an FGF2 including the amino acid sequence as shown in Figure 17.

The term "crystalline form," in the context ofthe invention, refers to a crystal formed from an aqueous solution comprising a purified polypeptide. In certain embodiments, a crystal is formed from an aqueous solution comprising all or part ofthe extracellular domain of an RPTK. A crystalline form of a polypeptide is characterized as being capable of diffracting x-rays in a pattern defined by one ofthe crystal forms depicted in Blundel et al, 1976, Protein Crystallography, Academic Press, and in Hahn, 1996, The International Tables or Crystallography, Volume A, Fourth Edition, Kluwer Academic Publishers. In preferred embodiments, a crystalline form may also be formed from a purified polypeptide corresponding to all or part of the extracellular domain of an RPTK in a complex with one or more ligands or ligand analogs, as defined herein.

A crystalline form of an RPTK may also comprise a crystal formed from an aqueous solution comprising a purified polypeptide corresponding to all or part ofthe extracellular domain of an RPTK, with or without a complexed ligand or ligand analogue, into which one or more heavy atoms are introduced. Preferably, introduction of a heavy atom results in as minimal a change to the original crystalline structure as possible. A heavy atom can be introduced into the protein crystal by well known techniques. Preferred reagents for introduction of heavy atoms are platinum tetrachloride, mercuric acetate, ethyl mercury thiosalicylate, iridium hexachloride, gadolinium sulfate, samarium acetate, gold chloride, uranyl acetate, mercury chloride, and ethyl mercury chloride. The term "receptor protein tyrosine kinase," or "RPTK," as used herein refers to an enzyme comprising an intracellular catalytic domain capable of transferring the high energy phosphate of adenosine triphosphate to a tyrosine residue located on a protein target, an extracellular domain that serves as a receptor for a specific ligand or set of ligands, and a membrane-spanning domain linking the intracellular and extracellular domains. In v vo, the binding of a ligand to its receptor results in receptor dimerization and activation ofthe intracellular catalytic domain. Preferred RPTKs ofthe invention are PDGFR, SCFR, EGFR, VEGFR, HGFR, neurotrophinR, HER2, HER3, HER4, InsulinR, IGFR, CSFIR, FLK, KDR, VEGFR2, CCK4, MET, TRKA, AXL, TIE, EPH, RYK, DDR, ROS, RET, LTK, ROR1, or MUSK. More preferably, a receptor PTK ofthe invention is a member ofthe FGFR family, such as FGFRl , FGFR2, FGFR3, and FGFR4. Certain receptor PTKs have no known ligand, and are referred to as "orphan receptor PTKs."

The term "FGFRl" refers to one member of multiple receptor PTKs that are homologous to one another, and which bind FGF. In this context, the term "homologous" preferably refers to about 70% or greater amino acid identity between two members ofthe FGFR family, more preferably at least about 80% amino acid identity, and most preferably at least about 90% amino acid identity. The term "FGFRl" includes human FGFRl which comprises or consists ofthe amino acid sequence of residues 150-360 of FGFRl as shown in Figure 4. "Homologous" in this and other contexts also includes molecules of similarity sufficient to indicate relation by a common origin or archetype. As used herein, the term "extracellular domain" refers to all or a portion ofthe region of an RPTK that exists outside the plasma membrane of a cell. Preferably, an extracellular domain is anchored to the plasma membrane by a polypeptide region that associates with the plasma membrane, and most preferably by a polypeptide region that is embedded within or crosses the plasma membrane. An extracellular domain can also be a soluble domain that is not anchored to the plasma membrane of a cell. Most preferably, an extracellular domain comprises one or more binding sites for one or more ligands. RPTK extracellular domains can comprise one or more known structural motifs. Preferably, these structural motifs can be one or more ofthe following: cysteine-rich regions, fibronectin Ill-like domains, Ig-like domains, EGF-like domains, factor VHI-like domains, and Kringle domains. Most preferred are RPTKs comprising one or more IG-like domains. For example, FGFRl , FGFR2, FGFR3, and FGFR4 each contain three IG-like domains, labeled Dl, D2, and D3. Other preferred RPTKs comprising IG-like domans include, but are not limited to, PDGFR, c-Kit, Flkl, Flk2, Flk4, KLG, TrkA, TrkB, TrkC, Axl, Tie, c-Eyk, and Elk.

The term "ligand" as used herein refers to a molecule that specifically binds to a receptor. In various embodiments, ligands are growth factors, cytokines, lymphokines, or hormones. Preferred ligands include, but are not limited to, epidermal growth factors, insulin, platelet-derived growth factors, stem cell factors, vascular endothelial growth factors, hepatocyte growth factors, and neurotrophins. Particularly preferred ligands are fibroblast growth factors. The term "fibroblast growth factor" as used herein refers to a family of polypeptide growth factors that share extensive sequence homologies and a common structural fold. At the time ofthe invention, the FGF family contains about 21 known members, named FGF1 through FGF21. Those skilled in the art will understand that other members ofthe FGF family may be later identified and used in practicing the present invention. FGFs bind to FGFRs, and to HSPGs. Preferred FGFs are FGF1, FGF2, FGF3, and FGF4.

The term "ligand analog" as used herein refers to a molecule that is structurally or functionally similar to a ligand and that binds to the ligand binding site on a polypeptide. A ligand analog may be structurally similar to a ligand if the analog results from the substitution, addition, or deletion of one or more atoms, functional groups, or amino acid residues of a ligand. A ligand analog is functionally similar to a ligand if the ligand analog binds to the ligand binding site ofthe ligand receptor, or if binding ofthe ligand analog to the ligand receptor results in a similar biochemical event(s) to those resulting from ligand binding. Such a ligand analog may also be referred to as a ligand "mimic."

Binding of a ligand analog may also result in an inhibition of one or more biochemical events which result from ligand binding, or may act as a competitor of ligand binding. Such a ligand analog may also be referred to as an "inhibitor." A ligand analog may also bind to the putative ligand binding site of an orphan receptor PTK. A ligand analog may preferably bind to its ligand receptor with lower, equal, or greater affinity than does the corresponding ligand. In certain embodiments, a ligand analog may be a mutant ligand. The term "mutant" is defined herein.

The term "bind" as used herein refers to a specific interaction of two or more molecules. Binding preferably refers to noncovalent binding. Such binding is typically mediated by one or more of hydrogen-bonding, van der Waals interactions, aromatic interactions, electrostatic interactions, and hydrophobic interactions. In certain embodiments, binding can refer to covalent binding of two or more molecules.

The term "catalytic domain" refers to a region of a protein that can exist as a separate entity from the protein, but that retains complete or partial catalytic function. The catalytic domain of a protein tyrosine kinase is characterized as having considerable amino acid identity to the catalytic domain of other protein tyrosine kinases. The catalytic domain of a protein tyrosine kinase is also characterized as being a polypeptide that is soluble in solution. The term "considerable amino acid identity" preferably refers to at least about 30% identity, more preferably at least about 35% identity, and most preferably at least about 40% identity. These degrees of amino acid identity refer to the identity between different protein tyrosine kinase families. Amino acid identity for members of a given protein tyrosine kinase family range from about 55% to about 90%.

The term "identity" as used herein refers to a property of sequences that measures their similarity or relationship. Identity is measured by dividing the number of identical residues in the two sequences by the total number of residues and multiplying the product by 100. Thus, two copies of exactly, the same sequence have 100% identity, but sequences that are less highly conserved and have deletions, additions, or replacements have a lower degree of identity. Two sequences may also be homologous to one another. The term "homologous" is defined herein, and can include, but is not limited to molecules (e.g., proteins) of similarity sufficient to indicate relation by a common origin or archetype.. Those skilled in the art will recognize that several computer programs are available for determining sequence identity and homology, including BLAST (Altschul, etal, 1990, J. Mol. Biol. 215:403-410) and FASTA (Pearson and Lipman, 1988, Proc. Natl. Acad. Sci. USA 85:2444-2448). The term "functional" refers to the ability of a portion of a protein to retain all or partial function ofthe intact protein. For example, a functional RPTK catalytic domain may retain the ability to convert a substrate into a product by phosphorylating the substrate, while a functional RPTK extracellular domain may retain the ability to bind to its ligand.

In certain embodiments, a polypeptide can exist as an extracellular domain, even though it is not functional. For example, a polypeptide corresponding to an extracellular domain may not comprise all ofthe structures necessary for binding a ligand or ligand analog. In these embodiments, a measure of an RPTK extracellular domain can be a polypeptide that is homologous to other RPTK extracellular domains.

In another embodiment, the crystal comprises a polypeptide, which includes an extracellular domain of a receptor protein tyrosine kinase, and a ligand bound to the extracellular domain. For example, the receptor protein tyrosine kinase can be a fibroblast growth factor receptor, such as FGFRl or FGFR2, and the ligand can be a fibroblast growth factor, such as FGF1 or FGF2. The crystal may also include a sulfated oligosaccharide bound to the receptor protein tyrosine kinase and/or a ligand bound thereto. The size (and thus molecular weight) ofthe sulfated oligosaccharide may vary. Examples of suitable sulfated oligosaccharide which may be contained in the crystal include a sulfated disaccharides, hexasaccharides, octasaccharides, decasaccharides, dodecasaccharides. Preferably, the sulfated oligosaccharide is sulfated mucooligosaccharide, such as heparin. In a particular aspect of this embodiment, the crystal includes a FGF:FGFR:heparin ternary complex. For example, the crystal can include a FGF:FGFR:heparin ternary complex such as an FGF 1 :FGFR1 :heparin ternary complex, an FGF2:FGFR1 :heparin ternary complex, an FGF1 :FGFR2:heparin ternary complex, or an FGF2:FGFR2:heparin ternary complex.

In certain other aspects, a crystal may comprise a polypeptide which includes the receptor binding core of a stem cell factor. The receptor binding core generally has a three dimensional structure which includes a four-helix bundle and two β strands. Stem cell factors and fragments containing the receptor binding core typically crystallize in a form which includes a homodimer ofthe polypeptide. While the monomers which make up the homodimer may be covalently linked, e.g., by one or more intermolecular disulfide bonds, the SCF crystals described herein include a noncovalent homodimer. The SCF homodimer forms orthorhombic crystal which has unit cell dimensions: a = 72.47 A, b = 83.45A and c = 89.15A. The SCF homodimer may also be crystallized (e.g., in the presence of to form monoclinic crystals. Monoclinic crystals of a noncovalent SCF homodimer were used to obtain the atomic structural coordinates shown in Table 4. These atomic coordinates are for crystals formed from a homodimer of a polypeptide which contains amino acid residues 1- 141 of stem cell factor. These crystals have C2 symmetry. Crystals of this type may also include an RPTK, such as c-kit (SCFR) bound to a stem cell factor or fragment thereof. Preferably, the crystal includes c-kit bound to the receptor binding core of a stem cell factor. The term "polypeptide" refers to an amino acid chain representing a portion of, or the entire sequence of, amino acid residues comprising a protein.

The term "association" refers to a condition of proximity between a chemical entity or compound, or portions or fragments thereof, and RPTK, or portions or fragments thereof. The association may be non-covalent, i.e., where the juxtaposition is energetically favored by, e.g., hydrogen-bonding, van der Waals, electrostatic or hydrophobic interactions, or it may be covalent.

The terms "heavy atom" and "heavy metal atom" refer to an atom that is a transition element, a lanthanide metal, or an actinide metal. Lanthanide metals include elements with atomic numbers between 57 and 71, inclusive. Actinide metals include elements with atomic numbers between 89 and 103, inclusive. In preferred embodiments, a crystal ofthe invention can comprise one or more heavy metal atoms. Such a crystal is referred to herein as a "derivative crystal."

In another aspect, the invention features a crystalline form of a polypeptide corresponding to the D2-D3 region of an RPTK extracellular domain. In preferred embodiments, the invention features a crystalline form ofthe D2-D3 region of a receptor PTK extracellular domain bound to a ligand or ligand analog. In preferred embodiments, the RPTK is an FGFR, such as FGFRl or FGFR2, and the ligand is an FGF, preferably FGF1 or FGF2. In particularly preferred embodiments, the polypeptide comprises residues 150-360 of FGFRl or residues 150-360 ofFGFR2 the sequences of which are shown in Figure 4. The ligand may counterpart protein or a mimic thereof. For example, where the RPTK includes the extracellular binding domain of FGFRl or FGFR2, the ligand can be a fibroblast growth factor, such as an FGF1 including the amino acid sequence as shown in Figure 17 or an FGF2 including the amino acid sequence as shown in Figure 17.

The term "D2-D3 region" as used herein refers to the second and third Ig-like domains of an FGFR. The term "Ig-like domain" is well known to those of skill in the art. In certain embodiments, the D2-D3 region ofthe invention may not comprise the entire second and third Ig-like domains, but contain sufficient residues to provide a binding site for the ligand ofthe FGFR. Most preferably, the term "D2-D3 region" refers to proteins which include residues 150-360 of human FGFRl.

The term "mutant" refers to a polypeptide which is obtained by replacing at least one amino acid residue in a native RPTK or polypeptide ligand with a different amino acid residue. Mutation can also be accomplished by adding and/or deleting amino acid residues within the native polypeptide or at the N- and/or C-terminus of a polypeptide. Preferably, a mutant polypeptide has substantially the same three-dimensional structure as the native polypeptide. The term "having substantially the same three-dimensional structure" as used herein refers to a set of atomic structure coordinates that have a root mean square deviation (r.m.s.d.) of less than or equal to about 2 A when superimposed with the atomic structure coordinates ofthe native polypeptide from which the mutant is derived, when at least about 50% to 100% ofthe Cα atoms ofthe native tyrosine kinase are included in the superposition. In another aspect, the invention relates to a crystalline form of an RPTK extracellular domain bound to a ligand defined by the structural coordinates set forth in Table 1 or Table 2.

The term "atomic structural coordinates" as used herein refers to a data set that defines the three dimensional structure of a molecule or molecules. Structural coordinates can be slightly modified and still render nearly identical three dimensional structures. A measure of a unique set of structural coordinates is the root-mean-square deviation ofthe resulting structure. Structural coordinates that render three dimensional structures that deviate from one another by a root-mean-square deviation of less than about 1.5 A may be viewed by a person of ordinary skill in the art as identical. Hence, the structural coordinates set forth in Tables 1-4 and 6 are not limited to the values defined therein. The use of X-ray crystallography can elucidate the three dimensional structure of crystalline forms ofthe invention. Typically, the first characterization of crystalline forms by X-ray crystallography can determine the unit cell shape and its orientation in the crystal. The term "unit cell" refers to the smallest and simplest volume element of a crystal that is completely representative ofthe unit of pattern ofthe crystal. The dimensions ofthe unit cell are defined by six numbers: dimensions a, b and c and angles α, β and γ. A crystal can be viewed as an efficiently packed array of multiple unit cells. Detailed descriptions of crystallographic terms are described in Hahn, 1996, The International Tables for Crystallography, Volume A, Fourth Edition, Kluwer Academic Publishers; and Shmueli, The International Tables for Crystallography, Volume B, First Edition, Kluwer Academic Publishers.

In another aspect, the invention features a crystalline form of a polypeptide corresponding to the D2-D3 region of a receptor PTK extracellular domain bound to a ligand or ligand analog, where the crystal is characterized by having tetragonal unit cells and space group symmetry P4j2ι2. In preferred embodiments, the RPTK is an FGFR, preferably FGFRl, and the ligand is an FGF, preferably FGF2. In particularly preferred embodiments, the polypeptide includes residues 150-360 of FGFRl or residues 150-360 of FGFR2, the sequences of which are shown in Figure 4. Most preferably, the invention features a crystalline form of FGFRl D2-D3 bound to FGF2, where the tetragonal unit cells ofthe crystal have dimensions of about a=98.5 A, b=98.5 A, c=197.0 A and β=90°.

In yet another aspect, the invention features a crystalline form of a polypeptide corresponding to the D2-D3 region of a receptor PTK extracellular domain bound to a ligand or ligand analog, where the crystal is characterized by having tetragonal unit cells and space group symmetry PI. In preferred embodiments, the RPTK is an FGFR, preferably FGFRl, and the ligand is an FGF, preferably FGF1. In particularly preferred embodiments, the polypeptide comprises residues 150-360 of FGFRl or residues 150-360 of FGFR2, the sequences of which are shown in Figure 4. Most preferably, the invention features a crystalline form of FGFRl D2-D3 bound to FGF 1 , where the tetragonal unit cells of the crystal have dimensions of about a=62.55 A, b=64.06 A, c=64.14 A, α=93.40°, β=l 11.17°, and γ=97.18°.

In yet another aspect, the invention features a crystalline form of a polypeptide corresponding to the D2-D3 region of a receptor PTK extracellular domain bound to a ligand or ligand analog, where the crystal is characterized by having triclinic unit cells and space group symmetry PI . In preferred embodiments, the RPTK is an FGFR, such as FGFR2, and the ligand is an FGF, such as FGF2. In particularly preferred embodiments, the polypeptide comprises residues 150-360 of FGFR2, the sequence of which are shown in Figure 4, and FGF2 has the sequence set forth in Figure 17. For example, there is a crystalline form of FGFR2 D2-D3 bound to FGF2 having triclinic unit cells with dimensions of about a=72.20 A, b=71.68 A, c=90.92 A, α=90.53°, β=89.98°, and γ=89.99°. The term "space group" refers to the symmetry of a unit cell. In a space group designation (e.g., P4!2ι2, or PI) the capital letter indicates the lattice type and the other symbols represent symmetry operations that can be carried out on the unit cell without changing its appearance. The term "lattice" in reference to crystal structures refers to the array of points defined by the vertices of packed unit cells.

The term "symmetry operations" refers to geometrically defined ways of exchanging equivalent parts of a unit cell, or exchanging equivalent molecules between two different unit cells. Examples of symmetry operations are screw axes, centers of inversion, and mirror planes.

By "isolated" in reference to a polypeptide is meant a polymer of, for example, 6, 12, 18 or more amino acids linked to each other by chemical (e.g., peptide) bonds, including polypeptides that are isolated from natural or recombinant sources or that are chemically synthesized. The isolated polypeptides ofthe present invention are unique in the sense that they are not found in a pure or separated state in nature. Use ofthe term "isolated" indicates that a naturally occurring sequence, or an analog thereof, has been removed from its normal cellular environment. Thus, the sequence may be in a cell-free solution or placed in a different cellular environment. The term does not imply that the sequence is the only amino acid chain present, but that it is essentially free (about 90 - 95% pure at least) of other material.

The term "enriched" as used herein in reference to a polypeptide refers to a specific amino acid sequence constituting a significantly higher fraction ofthe total of polypeptides present in the cells or solution of interest than in the cells or solution from which the sequence was taken. Preferably, a polypeptide is enriched about 2-fold, about 3-fold, about 5- fold, about 10-fold, about 20-fold, about 50-fold, or about 100-fold. Enrichment may be effected by preferential reduction in the amount of other polypeptides, or by a preferential increase in the amount ofthe specific polypeptide of interest, or by a combination ofthe two. However, it should be noted that "enriched" does not imply that there are no other polypeptides present, just that the relative amount ofthe polypeptide of interest has been significantly increased. The term "significant" here is used to indicate that the level of increase is useful to the person making such an increase, and generally means an increase relative to other amino acids of about at least 2 fold, more preferably about 2-fold, about 3- fold, about 5-fold, about 10-fold, about 20-fold, about 50-fold, about 100-fold, or more.

It is also advantageous for some purposes that an amino acid sequence be in purified form. The term "purified" as used herein in reference to a polypeptide does not refer to absolute purity (such as a homogeneous preparation); instead, it refers to a polypeptide that is relatively purer than in the natural environment. Preferably, a polypeptide is purified about 2- fold, about 3-fold, about 5-fold, about 10-fold, about 20-fold, about 50-fold, or about 100- fold. Most preferably, purification of at least one order of magnitude, preferably two or three orders, and more preferably four or five orders of magnitude is expressly contemplated. In preferred embodiments, the substance is free of contamination at a functionally significant level.

In another aspect, the invention features a method for creating crystalline forms described herein. The method may utilize the polypeptides described herein to form a crystal. The method comprises the steps of: (a) mixing a volume of polypeptide solution with a reservoir solution; and

(b) incubating the mixture obtained in step (a) over the reservoir solution in a closed container, under conditions suitable for crystallization.

Preferably, the polypeptide solution comprises about 1 mg/ml to about 50 mg/ml of the polypeptide to be crystallized, and most preferably about 1 mg/ml, 2 mg/ml, 5 mg/ml, about 10 mg/ml, about 15 mg/ml, about 20 mg/ml, about 25 mg/ml, about 30 mg/ml, about 35 mg/ml, about 40 mg/ml, about 45 mg/ml, and about 50 mg/ml. The polypeptide solution is preferably buffered to between about pH 6.5 and about pH 9.5, most preferably about pH 8.5. In preferred embodiments, the solution also comprises salt, preferably in the form of KC1 or NaCl, between about 1 mM and about 500 mM, most preferably about 150 mM. In certain embodiments, the reservoir solution preferably comprises between about 0.5 and about 3 M ammonium sulfate, most preferably about 1.6 M ammonium sulfate, and between about 5% and about 50% glycerol, most preferably 20% glycerol. In other embodiments, the reservoir solution preferably comprises between about 5% and about 50% polyethylene glycol, and most preferably about 20%, and between 0.05 M and 0.5 M Li₂SO₄, most preferably about ' 0.2 M. The reservoir solution is preferably buffered to between about pH 6.5 and about pH 9.5, and most preferably about pH 8.5. These processes are described in detail in the section entitled "Detailed Description ofthe Invention." In another aspect, the invention features a three dimensional representation of a structure of an RPTK extracellular domain, alone or in complex with a ligand or ligand analog. In preferred embodiments, the invention features a three dimensional representation of a structure ofthe D2-D3 region of a receptor PTK extracellular domain bound to a ligand or ligand analog. In preferred embodiments, the RPTK is an FGFR, such as FGFRl or FGFR2, and the ligand is an FGF, preferably FGFl or FGF2. In one group of preferred embodiments, the polypeptide comprises residues 150-360 of FGFRl or residues 150-360 of FGFR2, the sequences of which are shown in Figure 4. The ligand can be a fibroblast growth factor, such as an FGFl including the amino acid sequence as shown in Figure 17 or an FGF2 including the amino acid sequence as shown in Figure 17.

The term "three dimensional representation" as used herein refers to any non-natural representation of one or more molecules which utilize a three dimensional coordinate space. The skilled artisan will recognize that the atomic structural coordinates in Tables 1-4 and 6, for example, use a three dimensional coordinate space, and thus are three dimensional representations. In preferred embodiments, a three dimensional representation can be a model prepared from the atomic coordinates of one or more molecules. In particularly preferred embodiments, a three dimensional representation can be a model prepared from the atomic coordinates of one or more molecules that exists in a computer's memory and/or that is displayed on a computer's screen. The coordinates disclosed herein provide the skilled person with the information needed to study molecular structures and interactions.

Comparable data can be obtained by crystallizing the molecules in view ofthe teachings contained herein and conducting x-ray analysis in accordance with the teachings contaqined herein. Such data so obtained are within the scope ofthe present invention. Moreover, variations made to the data contained herein are within the scope ofthe present invention. In another aspect, the invention features a recombinant DNA encoding an RPTK extracellular domain. For example, the recombinant DNA can include a coding strand which includes a nucleotide sequence coding for amino acid residues 150-360 of FGFRl or residues 150-360 of FGFR2, the sequences of which are shown in Figure 4.

In yet another aspect, the invention relates to methods of determining three dimensional structures of RPTK extracellular domains with unknown structure by utilizing known atomic structural coordinates of an RPTK extracellular domain. These methods can relate to homology modeling, molecular replacement, and nuclear magnetic resonance methods.

In preferred embodiments, the invention relates to a method of determining three dimensional structures of RPTK extracellular domains with unknown structures by homology modelling. These methods use the known atomic structural coordinates of an RPTK extracellular domain in conjunction with the amino acid sequences of receptor PTKs having unknown three dimensional structures. The methods comprise the steps of: (a) aligning an amino acid sequence of an RPTK with unknown structure with that of an RPTK with known atomic structural coordinates, where alignment is achieved by matching homologous regions of the amino acid sequences; (b) transferring the atomic structural coordinates of each of the homologous amino acids from the known atomic structural coordinates to a computer representation of a structure ofthe corresponding amino acids in the RPTK sequence with unknown structure; and (c) determining low energy conformations ofthe resulting RPTK structure. Preferably, the known atomic structural coordinates are of an RPTK extracellular domain bound to a ligand or ligand analog. More preferably, the known atomic structural coordinates are of an FGFR extracelluar domain, preferably FGFRl, bound to an FGF, preferably FGFl or FGF2. Most preferably, the known atomic structural coordinates are the coordinates set forth in Table 1 or Table 2. The term "amino acid sequence" describes the order of amino acids in the amino acid chain comprising a polypeptide corresponding to all or a portion of an RPTK. In preferred embodiments, the amino acid sequence describes the order of amino acids in all or a portion ofthe extracellular domain of an RPTK.

The term "aligning" describes matching the beginning and the end of two or more amino acid sequences. Homologous amino acid sequences are placed on top of one another during the alignment process.

The term "homologous" as used herein in reference to protein sequences describes amino acids in two sequences that are identical or have similar side-chain chemical groups (e.g., aliphatic, aromatic, polar, negatively charged, or positively charged). Thus, protein sequences of similarity sufficient to indicate relation by a common origin or archetype are considered to possess homology, for instance. Examples of homologous amino acids are provided below. The term "corresponding" refers to an amino acid that is aligned with another in the sequence alignment mentioned above.

The term "determining the low energy conformation" describes a process of changing the conformation ofthe RPTK structure such that the structure is of low free energy. The RPTK structure may or may not have a molecule(s), such as a ligand or ligand analog, bound to it.

The term "low free energy" describes a state where the molecules are in a stable state as measured by the process. A stable state is achieved when favorable interactions are formed within the complex. The term "favorable interactions" refers to, among other things, hydrophobic, aromatic, and ionic forces, and hydrogen bonds.

The term "compound" refers to an organic molecule. The term "organic molecule" refers to a molecule which has at least one carbon atom in its structure. The compound can have a molecular weight of less than 6kDa. Both the geometry ofthe compound and the interactions formed between the compound and the polypeptide preferably govern high affinity binding between the two molecules. High affinity binding is preferably governed by a dissociation equilibrium constant on the order of 10^"6 M or less

The term "binding site" refers to a location on an enzyme or polypeptide chain to which one or more molecules may bind. In preferred embodiments, a binding site can be a ligand binding site, a HSPG binding site, or an interaction surface between two receptors which form a dimer upon ligand binding.

The term "interactions" refers to hydrophobic, aromatic, and ionic forces and hydrogen bonds formed between atoms. Such interactions can be "intramolecular," or within the same molecule, or "intermolecular," or between separate molecules. The term "cofactor" refers to a compound that may, in addition to the substrate, bind to a protein and undergo a chemical reaction. Multiple co-factors are nucleotides or nucleotide derivatives, such as phosphate and nicotinamide derivatives of adenosine.

The term "substrate" refers to a compound that reacts with an enzyme. Enzymes can catalyze a specific reaction on a specific substrate. For example, RPTKs can phosphorylate specific protein and peptide substrates on tyrosine moieties. In addition, nucleotides can act as substrates for protein kinases. The term "substrate analog" refers to a compound that is structurally similar, but not identical, to a substrate. The substrate analog may be a nucleotide analog. Examples of nucleotide analogs are described below.

The term "allosteric effector" refers to a compound that causes allosteric interactions in a protein. The term "allosteric interactions" refers to interactions between separate sites on a protein. The sites can be different from the active site. The allosteric effector can enhance or inhibit catalytic activity by binding to a site that may be different than the active site.

The term "co-crystal" refers to a crystal where the polypeptide is in association with one or more compounds. The term "ATP" refers to the chemical compound adenosine triphosphate.

The term "non-hydrolyzable" refers to a compound having a covalent bond that does not readily react with water. Examples of non-hydrolyzable analogs of ATP are AMP-PNP and AMP-PCP, whose structures are well known to those skilled in the art.

The term "AMP-PNP" refers to adenylyl imidodiphosphate, a non-hydrolyzable analog of ATP.

The term "AMP-PCP" refers to adenylyl diphosphonate, a non-hydrolyzable analogue of ATP.

"Alkyl" refers to a straight-chain, branched or cyclic saturated aliphatic hydrocarbon. Preferably, the alkyl group has 1 to 12 carbons. More preferably, it is a lower alkyl of from 1 to 7 carbons, more preferably 1 to 4 carbons. Typical alkyl groups include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertiary butyl, pentyl, hexyl and the like. The alkyl group may preferably be optionally substituted with one or more substituents selected from the group consisting of hydroxyl, cyano, alkoxy, =O, =S, NO₂, halogen, N(CH₃)₂ amino, and SH. "Alkenyl" refers to a straight-chain, branched or cyclic unsaturated hydrocarbon group containing at least one carbon-carbon double bond. Preferably, the alkenyl group has 2 to 12 carbons. More preferably it is a lower alkenyl of from 2 to 7 carbons, more preferably 2 to 4 carbons. The alkenyl group may preferably be optionally substituted with one or more substituents selected from the group consisting of hydroxyl, cyano, alkoxy, =O, =S, NO₂, halogen, N(CH₃)₂ amino, and SH. "Alkynyl" refers to a straight-chain, branched or cyclic unsaturated hydrocarbon containing at least one carbon-carbon triple bond. Preferably, the alkynyl group has 2 to 12 carbons. More preferably it is a lower alkynyl of from 2 to 7 carbons, more preferably 2 to 4 carbons. The alkynyl group may preferably be optionally substituted with one or more substituents selected from the group consisting of hydroxyl, cyano, alkoxy, =O, =S, NO₂, halogen, N(CH₃)₂ amino, and SH.

"Alkoxy" refers to an "O-alkyl" group. "Aryl" refers to an aromatic group which has at least one ring having a conjugated pi- electron system and includes carbocyclic aryl, heterocyclic aryl and biaryl groups. The aryl group may preferably be optionally substituted with one or more substituents selected from the group consisting of halogen, trihalomethyl, hydroxyl, SH, OH, NO₂, amine, thioether, cyano, alkoxy, alkyl, and amino. "Alkaryl" refers to an alkyl that is covalently joined to an aryl group. Preferably, the alkyl is a lower alkyl.

"Carbocyclic aryl" refers to an aryl group wherein the ring atoms are carbon. "Heterocyclic aryl" refers to an aryl group having from 1 to 3 heteroatoms as ring atoms, the remainder ofthe ring atoms being carbon. Heteroatoms include oxygen, sulfur, and nitrogen. Thus, heterocyclic aryl groups include furanyl, thienyl, pyridyl, pyrrolyl, N- lower alkyl pyrrolo, pyrimidyl, pyrazinyl, imidazolyl and the like.

"Amide" refers to -C(O)-NH-R, where R is alkyl, aryl, alkylaryl or hydrogen. "Thioamide" refers to -C(S)-NH-R, where R is alkyl, aryl, alkylaryl or hydrogen. "Amine" refers to a -N(R')R" group, where R' and R" are independently selected from the group consisting of alkyl, aryl, and alkylaryl.

"Thioether" refers to -S-R, where R is alkyl, aryl, or alkylaryl. "Sulfonyl" refers to -S(O)₂-R, where R is aryl, C(CN)=C-aryl, CH₂CN, alkyaryl, sulfonamide, NH-alkyl, NH-alkylaryl, or NH-aryl.

The term "acyl" denotes groups -C(O)R, where R is alkyl as defined above, such as formyl, acetyl, propionyl, or butyryl.

In other preferred embodiments, the invention relates to methods of determining three dimensional structures of RPTK extracellular domains with unknown structures by applying the known atomic structural coordinates of an RPTK extracellular domain to incomplete X- ray crystallographic data sets for RPTK extracellular domains having unknown three dimensional structures. The methods comprise the steps of: (a) determining the positions of atoms in the unit cell by matching diffraction data from two crystals, where one data set is from a crystal comprising an RPTK of unknown structure and the other is from a crystal comprising an RPTK having known atomic structural coordinates; and (b) determining a low energy conformation ofthe resulting RPTK structure.

Preferably, the complete diffraction data is from a crystal of an RPTK extracellular domain bound to a ligand or ligand analog. More preferably, the complete diffraction data is from a crystal of an FGFR extracelluar domain, preferably FGFRl , bound to an FGF, preferably FGFl or FGF2.

The diffraction data set from the crystal comprising an RPTK of unknown structure may be a complete data set or an incomplete data set. The term "incomplete data set" as used herein relates to a X-ray crystallographic data set that does not have enough information to give rise to a three dimensional structure.

In other preferred embodiments, the invention relates to methods of determining three dimensional structures of receptor PTK extracellular domains with unknown structure by applying the known atomic structural coordinates of an RPTK extracellular domain to nuclear magnetic resonance (NMR) data of RPTK extracellular domains having unknown three dimensional structures. The methods comprise the steps of: (a) determining the secondary structure of an RPTK extracellular domain of unknown three dimensional structure using NMR data; and (b) simplifying the assignment of through-space interactions of amino acids using the known atomic structural coordinates of an RPTK. The RPTK extracellular domain of unknown three dimensional structure may or may not be complexed with compounds, ligands or modulators.

Preferably, the known atomic structural coordinates are of an RPTK extracellular domain bound to a ligand or ligand analog. More preferably, the known atomic structural coordinates are of an FGFR extracelluar domain, preferably FGFRl, bound to an FGF, preferably FGFl or FGF2. Most preferably, the known atomic structural coordinates are the coordinates set forth in Table 1 or Table 2.

The term "secondary structure" describes the arrangement of amino acids in a three dimensional structure, such as in α-helix or β-sheet elements.

The term "through-space interactions" defines the orientation ofthe secondary structural elements in the three dimensional structure and the distances between amino acids from different portions ofthe amino acid sequence.

The term "assignment" defines a method of analyzing NMR data and identifying which amino acids give rise to signals in the NMR spectrum. In another aspect, the invention features methods of identifying potential modulators of PTK function. By identifying one or more potential modulators from a larger group of molecules, it is possible to reduce the number of molecules that must be tested using costly and time-consuming biological assays. Thus, the methods described herein for identifying potential modulators of PTK function can provide increased efficiencies in identifying actual modulators of PTK function.

These potential modulators are preferably identified by docking a three dimensional representation of a structure of a compound with a three dimensional representation ofthe RPTK extracellular domain. The computer representation ofthe RPTK extracellular domain can be defined by atomic structural coordinates. In certain embodiments, one or more modulators are docked into the ligand binding site ofthe RPTK extracellular domain, and/or into the binding site for heparin sulfate-containing proteoglycans (HSPGs) ofthe RPTK extracellular domain.

In preferred embodiments, the method of identifying potential modulators of RPTK function comprises the steps of: (a) providing a three dimensional representation of the atomic structural coordinates of an RPTK and docking a three dimensional representation of a compound from a computer data base with the three dimensional representation ofthe RPTK; (b) determining a conformation ofthe resulting complex having a favorable geometric fit and favorable complementary interactions; and (c) identifying compounds that best fit the RPTK as potential modulators of RPTK function. The initial RPTK structure may or may not have one or more compounds, ligands, or modulators bound to it.

Preferably, the atomic structural coordinates are of an RPTK extracellular domain bound to a ligand or ligand analog. More preferably, the atomic structural coordinates are of an FGFR extracelluar domain, preferably FGFRl, bound to an FGF, preferably FGFl or FGF2. Most preferably, the atomic structural coordinates are the coordinates set forth in Table 1 or Table 2.

The term "modulator of RPTK function" as used herein refers to a compound or ligand analog which alters the catalytic activity of an RPTK. A modulator of RPTK function can either stimulate or inhibit RPTK catalytic activity. For example, inhibitory modulators may be one or more compounds or ligand analogs that disrupt dimerization of an RPTK, prevent dimerization of an RPTK, or prevent binding of an RPTK to its ligand or to HSPGs. Alternatively, a stimulatory modulator may be one or more compounds or ligand analogs that stabilize dimer formation, or mimic the activity ofthe ligand of an RPTK, or mimic the activity of HSPGs.

The term "chemical group" refers to moieties that can form hydrogen bonds, hydrophobic, aromatic, or ionic interactions. The term "docking" refers to a process of placing a compound, ligand or ligand analog in close proximity with an RPTK. In certain embodiments, docking can refer to placing a three dimensional representation ofthe compound, ligand, or ligand analog in close proximity with a three dimensional representation ofthe RPTK. The term can also refer to a process of finding low energy conformations ofthe resulting compound RPTK, ligand/RPTK, or ligand analog/RPTK complex.

The term "favorable geometric fit" refers to a conformation ofthe compound/RPTK, ligand/RPTK, or ligand analog/RPTK complex where the surface area of die compound, ligand, or ligand analog is in close proximity with a surface ofthe RPTK-site without forming unfavorable interactions. Unfavorable interactions can be steric hindrances between atoms in the bound molecule and atoms in the RPTK.

The term "favorable complementary interactions" relates to hydrophobic, aromatic, ionic, and hydrogen bond donating, and hydrogen bond accepting forces formed between the compound, ligand, or ligand analog and the RPTK.

The term "potential" qualifies the term "modulator of RPTK function" because the potential modulator of RPTK function may not yet have been tested for activity in vitro or in vivo.

The term "best fit" describes compounds, ligands, or ligand analogs that complexed the most surface area and/or form the most favorable complementary interactions with the receptor PTK in a given experiment. The term "best fit" can also refer to a subset of compounds, ligands, or ligand analogs from amongst a larger group of compounds, ligands, or ligand analogs which complex the most surface area and or form the most favorable complementary interactions with the receptor PTK. In preferred embodiments, a molecule which exhibits a best fit is in the 70^th percentile or better of molecules tested in terms of complexing the most surface area and/or forming the most favorable complementary interactions, more preferably a molecule which exhibits a best fit is in the 80^th percentile or better of molecules tested, and most preferably, a molecule which exhibits a best fit is in the 90^th percentile or better of molecules tested. Other preferred embodiments ofthe invention are methods of identifying potential modulators of receptor PTK function. The method involves utilizing a three dimensional structure of a receptor PTK. The method comprises the steps of: (a) modifying a three dimensional representation of a receptor PTK having one or more compounds, ligands, or ligand analogs bound to it, where the three dimensional representations ofthe compounds, ligands, or ligand analogs and the receptor PTK are defined by atomic structural coordinates; (b) determining a conformation ofthe resulting complex having a favorable geometric fit and favorable complementary interactions; and (c) identifying the compounds, ligands, or ligand analogs that best fit the receptor PTK active-site as potential modulators of receptor PTK function.

Preferably, the atomic structural coordinates are of an RPTK extracellular domain bound to a ligand or ligand analog. More preferably, the atomic structural coordinates are of an FGFR extracelluar domain, preferably FGFRl, bound to an FGF, preferably FGFl or FGF2. Most preferably, the atomic structural coordinates are the coordinates set forth in Table 1 or Table 2.

The term "modifying" refers to replacing, deleting, or adding one or more chemical groups. Computer representations ofthe chemical groups can be selected from a computer data base.

Yet another preferred embodiment ofthe invention is a method of identifying potential modulators of RPTK function by operating modulator construction or modulator searching computer programs on the compounds, ligands, or ligand analogs complexed with the RPTK. The method comprises the steps of: (a) providing a three-dimensional representation of one or more compounds, ligands, or ligand analogs complexed with an RPTK, where the computer representations ofthe compounds, ligands, or ligand analogs and the receptor PTK are defined by atomic structural coordinates; and (b) searching a data base for compounds, ligands, or ligand analogs similar to the compounds, ligands, or ligand analogs using a compound searching computer program, or replacing portions ofthe compounds, ligands, or ligand analogs complexed with the RPTK with similar chemical structures from a data base using a compound construction computer program, where the representations ofthe compounds are defined by structural coordinates. The skilled artisan will recognize that a number of suitable computer programs are available for compound searching and construction, including UNITY™ (Tripos, Inc.) and CATALYST® (MSI, Inc.) Preferably, the atomic structural coordinates are of an RPTK extracellular domain bound to a ligand or ligand analog. More preferably, the atomic structural coordinates are of an FGFR extracelluar domain, preferably FGFRl, bound to an FGF, preferably FGFl or FGF2. Most preferably, the known atomic structural coordinates are the coordinates set forth in Table 1 or Table 2.

The term "operating" as used herein refers to utilizing the three-dimensional conformation of molecules defined by the processes described herein in various computer programs.

The terms "similar compound," "similar ligand," and "similar ligand analog" refer to a compound, ligand, or ligand analog that has a similar geometric structure as compounds, ligands, or ligand analogs that can bind to a receptor PTK. The similar molecule can also have similar chemical groups as a molecule that is either bound to an RPTK or once bound to an RPTK. The similar chemical groups can form complementary interactions with the RPTK. The term "compound searching computer program" describes a computer program that searches computer representations of compounds, ligands, or ligand analogs from a computer data base that have similar three dimensional structures and similar chemical groups as a compound of interest.

The term "similar chemical structures" as used herein refers to one or more chemical groups that share similar a similar geometry with one or more portions of another molecule. In preferred embodiments, a similar chemical structure shares a similar geometry with a molecule that is in a complex with an RPTK, or shares a similar geometry with a molecule that has been removed from an RPTK structure. Similar chemical structures can also refer to chemical groups that can form one or more complementary interactions with an RPTK that are similar to those formed between and an RPTK and a complexed molecule.

The term "replacing structures" refers to removing one or more portions of a molecule that is in a complex with an RPTK, or removing one or more portions of a molecule that has been removed from an RPTK, and connecting the broken bonds to produce a similar molecule. The term "compound construction computer program" describes a computer program that replaces computer representations of chemical groups in a compound, ligand, or ligand analog with groups from a computer data base. The term "similar three dimensional structure" describes two molecules with nearly identical shape and volume.

The methods for using the crystalline forms and three dimensional structures ofthe invention can relate to a broad range of protein kinases. Thus, in preferred embodiments, the invention relates to an RPTK. The RPTK is preferably PDGFR, EGFR, SCFR, VEGFR, HGFR, neurotrophinR, HER2, HER3, HER4, InsulinR, IGFR, CSFIR, FLK, KDR, VEGFR2, CCK4, MET, TRKA, AXL, TIE, EPH, RYK, DDR, ROS, RET, LTK, ROR1, MUSK, members ofthe FGFR family, such as FGFRl, FGFR2, FGFR3, and FGFR4, or an orphan receptor PTK. In another aspect, the invention features a potential modulator of RPTK function identified by methods disclosed in the invention.

Another aspect ofthe invention is a method for synthesizing a potential modulator of RPTK function or its pharmaceutically acceptable salts, isomers, metabolites, esters, amides, or prodrugs by a standard synthetic method known in the art. Synthetic procedures are discussed below.

In another aspect, the invention features methods for identifying a modulator of RPTK function. The method comprises the steps of: (a) administering a potential modulator of RPTK function, ligand, ligand analog, or compound to cells; (b) comparing the level of RPTK phosphorylation between cells not administered the potential modulator, ligand, ligand analog, or compound and cells administered the potential modulator; and (c) identifying the potential modulator, ligand, ligand analog, or compound as a modulator of RPTK function based on the difference in the level of receptor PTK phosphorylation. The skilled artisan will recognize that the difference in PTK phosphorylation required for a potential modulator, ligand, ligand analog, or compound to be identified as a modulator of RPTK function will depend on the particular RPTK, the specificity ofthe modulator, the nature ofthe disorder associated with the RPTK function, etc.

The term "cells" refers to any type of cells either primary or cultured. Primary cells can be extracted directly from an organism while cultured cells rapidly divide and can be cultured in many successive rounds. Cells can be grown in a variety of containers including, but not limited to flasks, dishes, and well plates.

The term "administer," as used in reference to cells, refers to a method of delivering a potential modulator, ligand, ligand analog, or compound to cells. The compound can be prepared using a carrier such as dimethyl sulfoxide (DMSO) in an aqueous solution. The aqueous solution comprising the compound, also termed an "aqueous preparation", can be simply mixed into the medium bathing the layer of cells or microinjected into the cells themselves. The compounds may be administered to the cells using a suitable buffered solution.

The term "suitable buffered solution" refers to an aqueous preparation ofthe compound that comprises a salt that can control the pH ofthe solution at low concentrations. Because the salt exists at low concentrations, the salt preferably does not alter the function of the cells. The term "RPTK phosphorylation" refers to the presence of phosphate on the RPTK.

Phosphates on RPTKs can be identified by antibodies that bind them specifically with high affinity.

In another aspect, the invention features a method of identifying a potential modulator of RPTK function as a modulator of RPTK function. The method comprises the steps of: (a) administering a potential modulator of RPTK function to cells; (b) comparing the level of cell growth between cells not administered the potential modulator and cells administered the potential modulator; and (c) identifying the potential modulator as a modulator of RPTK function based on the difference in cell growth.

The term "cell growth" refers to the rate at which a group of cells divides. Cell division rates can be readily measured by methods utilized by those skilled in the art. Another aspect ofthe invention features a method of diagnosing a disease by identifying cells harboring a RPTK with inappropriate activity. The method comprises the steps of: (a) administering a modulator of RPTK function to cells; (b) comparing the rate of cell growth between cells not administered the modulator and cells administered the modulator; and (c) diagnosing a disease by characterizing cells harboring a RPTK with inappropriate activity from the effect ofthe modulator on the difference in the rate of cell growth. The modulator can be identified by the methods ofthe invention.

The term "inappropriate activity" refers to an RPTK that regulates a step in a signal transduction process at a higher or lower rate than normal cells. Aberrations in the rate of signal transduction can be caused by alterations in the stimulation of an RPTK by a growth factor, alterations in the activity of RPTK -specific phosphatase, over-expression of a RPTK in a cell, or mutations in the catalytic region ofthe RPTK itself. The term "signal transduction process" describes the steps in a cascade of events where an extracellular signal is transmitted into an intracellular signal.

The term "RPTK -specific phosphatase" describes an enzyme that dephosphorylates a particular RPTK and thereby regulates that RPTK's activity. Another aspect ofthe invention is a method of treating a disease associated with a

RPTK with inappropriate activity in a cellular organism, where the method comprises the steps of: (a) administering the modulator of RPTK function to the organism, where the modulator is in an acceptable pharmaceutical preparation; and (b) activating or inhibiting the RPTK function to treat the disease. The term "organism" relates to any living being comprised of at least one cell. An organism can be as simple as one eukaryotic cell or as complex as a mammal.

The term "administering", in reference to an organism, refers to a method of introducing the compound to the organism. The compound can be administered when the cells or tissues ofthe organism exist within the organism or outside ofthe organism. Cells existing outside the organism can be maintained or grown in cell culture dishes. For cells harbored within the organism, many techniques exist in the art to administer compounds, including (but not limited to) oral, parenteral, dermal, ocular, subcutaneous, and rectal applications. For cells outside ofthe patient, multiple techniques exist in the art to administer the compounds, including (but not limited to) cell microinjection techniques, transformation techniques, and carrier techniques.

The term "pharmaceutically acceptable composition" refers to a preparation comprising the modulator of RPTK activity. The composition is acceptable if it does not appreciably cause irritations to the organism administered the compound.

In preferred embodiments ofthe ofthe invention, the receptor PTK is selected from the group consisting of PDGFR, SCFR, EGFR, VEGFR, HGFR, neurotrophinR, HER2, HER3, HER4, InsulinR, IGFR, CSFIR, FLK, KDR, VEGFR2, CCK4, MET, TRKA, AXL, TIE, EPH, RYK, DDR, ROS, RET, LTK, ROR1, MUSK, members ofthe FGFR family, such as FGFRl, FGFR2, FGFR3, and FGFR4, and orphan receptor PTKs.

The summary ofthe invention described above is non-limiting and other features and advantages ofthe invention will be apparent from the following detailed description, and from the claims. BRIEF DESCRIPTION OF THE FIGURES FIG. 1 provides a ribbon diagram ofthe structure of a dimer of FGFRl D2-D3. complexed with FGF2. Two views are related by a rotation of about 90° about the vertical axis. The D2 and D3 domains are shown in green and blue, respectively, the short linker connecting D2 and D3 is shown in gray, and the FGF2 molecules are shown in orange.

FIG. 2 provides a ribbon diagram ofthe structure of FGFRl D2-D3 complexed with FGFl . The D2 and D3 domains are shown in green and blue, respectively, the short linker connecting D2 and D3 is shown in gray, and FGFl is shown in orange.

FIG. 3 provides a topology diagram ofthe Ig folds of FGFRl D2 and D3 in comparison to the Ig fold of telokin.

FIG. 4 provides a sequence alignment ofthe D2-D3 region of human FGFl, FGF2, FGF3, and FGF4.

Figure 5 shows ribbon diagrams ofthe FGFl -FGFRl and FGF2-FGFR2 complexes with the Ig-like domains 2 (D2) and 3 (D3) are shown in green and cyan, respectively. The short linker that connects D2 and D3 is colored gray. FGFl and FGF2 are shown in orange. The secondary structure assignments for FGFRl and FGFR2 were obtained with the program PROCHECK (Laskowski et al., J. Appl. Cryst., 26, 283-291 (1993)). The beta strands for D2 and D3 are labeled according to the strand nomenclature for the canonical I-set member telokin. The helix between betaA and betaA¹, gA, is a 3JQ helix. In both FGFl -FGFRl and FGF2-FGFR2 structures, the betaC-betaC loops in D3 are disordered. In addition, most of the segment between betaC and betaE in D3 of FGFl -FGFRl is disordered as well. In the FGF2-FGFR2 structure, this segment is well ordered and is colored purple. The amino- and carboxy-termini are denoted by NT and CT. The disulfide bonds in D2 and D3 are shown in ball-and-stick rendering with sulfur atoms colored yellow. The beta strands of FGFl are labeled from 1 to 12 according to published nomenclature (Faham et al., Curr. Opin. Struct. Biol. 8, 578-586 (1998)). This figure was created using the programs Molscript (Kraulis, J. Appl. Crystallogr. 24, 946-950 (1991)) and Raster3D (Merrit et al., Methods Enzymol. 277, 505-524 (1997)).

Figure 6 shows Space-filling models ofthe FGF1-FGFR1 and FGF2-FGFR2 complexes. The view and the coloring for D2, D3, the linker and FGFs are the same as in Figure 5. To better visualize the binding interfaces on FGFs and on FGFRs, the molecules are pulled away from each other and rotated 90° about the vertical axis as indicated (left and right panels). Residues in FGFl and FGF2 are colored with respect to the FGFR regions with which they interact. FGFl and FGF2 residues that interact with D2 are colored green, residues that interact with the linker region are colored gray, and residues that interact with D3 are colored cyan. FGF2 residues that interact with the betaC'-betaE segment (shown in purple) of FGFR2 are colored red. The residues in FGFRl and FGFR2 that interact with FGFl and FGF2, respectively, are colored orange. In addition, in the FGF2-FGFR2 structure, receptor residues in the betaC'-betaE segment that contact FGF2 are in red. Ligand and receptor residues are considered to be in the FGF-FGFR interface if at least one pair of atoms (side chain or main chain) has an inter-atomic distance of 3.8 A or less. This figure was created using the programs Molscript and Raster3D.

Figure 7 shows a stereo view of detailed interactions in the hydrophobic interface between FGF2 and D2 of FGFR2

Figure 8 shows a stereo view of detailed interactions in the hydrophobic interface between between FGFl and D2 of FGFRl. Figure 9 shows a stereo view of detailed interactions ofthe conserved network of hydrogen bonds between FGF2 and FGFR2 in the vicinity of Arg251 in the D2-D3 linker.

Figure 10 shows a stereo view of detailed interactions the network of hydrogen bonds between FGFl and FGFRl in the vicinity of Arg250 in the D2-D3 linker.

Figure 11 shows a stereo view of detailed interactions in the interface between FGF2 and the betaF-betaG loop of D3 in the FGF2-FGFR2 structure. At the right side of each stereo pair, a view ofthe whole structure in the exact orientation as in stereo views is shown and the region of interest is highlighted. Only side chains of interacting residues are shown. Color coding is the same as in Figure 7. Dotted lines represent hydrogen bonds.

Figure 12 shows a stereo view of detailed interactions in the interface between N- terminal sequences (prior to betal) of FGF2 and D3 in the FGF2-FGFR2 structure. Views and coding are the same as in Figure 11.

Figure 13 shows a stereo view of detailed interactions in the interface between FGF2 and the betaC'-betaE segment (shown in purple) of D3 in the FGF2-FGFR2 structure. Views and coding are the same as in Figure 11. Figure 14 shows a stereo view of detailed interactions in the interface between FGFl and D3 in the FGFl -FGFRl structure. Views and coding are the same as in Figure 11. Figure 15 shows Structure-based sequence alignment ofthe ligand binding domains of D2 and D2-D3 linker of human FGF receptors.

Figure 16 shows Structure-based sequence alignment ofthe ligand binding domains of D3 of human FGF receptors. Figure 17 shows structure-based sequence alignment of FGFs performed using the

CLUSTALW program (Thompson et al., Nucleic Acids Res. 22, 4673-4680 (1994)). All of the FGFs used in this alignment are from human, with the exception of FGF 15, for which only the chicken sequence is available. The secondary structure assignment is according to the published nomenclature, with the beta strands labeled from 1 through 12 (Faham et al., Curr. Opin. Struct. Biol. 8, 578-586 (1998)). The location and the length ofthe beta strands are shown on the top ofthe sequence alignment. FGF residues are colored with respect to the region on FGFR with which they interact: FGF residues that interact with D2 are colored green, residues that interact with the linker region are colored gray, and residues that interact with D3 are colored cyan. FGF residues that interact with the betaC'-betaE segment in D3 are colored red. A period indicates sequence identity to FGF2. A dash represents a gap introduced to optimize the alignment. A tilde at the C-terminus of FGF indicates that there are additional sequences down stream to the last amino acid shown. A star indicates that numbering does not start at the initiation methionine. Residue numbering for FGF2 is according to Springer et., J. Biol. Chem. 269, 26879-26884 (1994). Residue numbering for FGFl is according to Zhu et al., Science 251, 90-93 (1991). A checkmark indicates FGF residues that have been shown by mutagenesis to be important for receptor binding.

Figure 18 depicts the locations ofthe mutations in the human FGFR2 gene that lead to skeletal disorders are mapped onto a ribbon representation the FGF2-FGFR2 structure. Side chains ofthe residues are colored with respect to the type of substitution. In yellow are mutations that substitute a cysteine with another amino acid or vice versa, resulting in the creation of unpaired cysteines. In red are mutations that are expected to destabilize the tertiary structure of D3 and thus disfavor the formation ofthe correct intra-domain disulfide bridge. In green are mutations that are predicted to affect ligand-binding affinity or specificity. Figure 19 depicts the overall structure of SCF (constructed by Molscript and Raster3D

(Kraulis, J. Appl. Crystallogr. 24, 946-950 (1991); Merrit et al., Methods Enzymol. 277, 505- 524 (1991))) and its relation with other cytokines by showing a ribbon representation ofthe SCF structure, in two views related by a rotation of approximately 90°. The termini and secondary structures are labeled; the strands are rendered as arrows, the helices as ribbons, and the loop regions as tubes. The two-fold axis is marked with a diamond.

Figure 20 depicts the sequence alignment based on secondary structures of SCF, M- CSF and IL-5. Secondary structure assignments for M-CSF and IL-5 are from PDB databank. beta-Strands are yellow and helices are marked bright green.

Figure 21 shows a stereo view ofthe dimeric interface of SCF constructed by Molscript and Raster3D (Kraulis, J. Appl. Crystallogr. 24, 946-950 (1991); Merrit et al., Methods Enzymol. 277, 505-524 (1991)). For clarity, only side-chains of residues at the core ofthe interface are shown. The coding ofthe secondary structures is the same as used in Fig. 19, the strands are rendered as arrows, the helices as ribbons, and the loop regions as tubes.

Figure 22 shows 2Fo-Fc electron density created by O (Jones et al., Acta Crystallogr. A 47, 110-119 (1991)), contoured at 1.2 , for the hydrogen bond circle of Tyr26 and Asp25' at the dimeric interface. Figure 23 depicts a model of covalent SCF dimer constructed by Molscript and

Raster3D (Kraulis, J. Appl. Crystallogr. 24, 946-950 (1991); Merrit et al., Methods Enzymol. 277, 505-524 (1991)). The non-covalent (native) dimer is on the left and a model for the covalent SCF dimer is on the right. Each protomer is colored either orange or green. The disulfide bonds are shown in ball-and-stick with sulfur atoms colored in yellow. Figure 24 depicts a potential binding site on SCF for c-kit and a model of SCF: SCFR complex created by GRASP (Nicolls et al., Proteins 11, 281-296 (1991)). The molecular surface of SCF and proposed c-kit binding regions, in two views related by a rotation of approximately 90° are shown. A hydrophobic crevice at both tails is colored yellow. Two basic patches are colored blue and the acidic patch is colored red. Figure 25 shows sequence alignments of human, rat, mouse, dog and pig SCFs.

Residues ofthe acidic patch are colored red and residues ofthe two basic patches are colored blue. Stars mark amino acid residues that are altered in rodents. The secondary structures are marked below the sequences with Η representing helices and 'E¹ representing beta strands

Figure 26 shows a proposed model ofthe SCF in complex with Ig-like domains 2-5 of the extracellular domain of c-kit (labeled D2 to D5) created by GRASP (Nicolls et al.,

Proteins 11, 281-296 (1991)). The SCF dimer is represented in a worm model and the c-kit model by a molecular surface. Figure 27 depicts an electron density map of decasaccharides soaked into preformed crystals of an FGF2-FGFR1 complex showing the location of decasaccharides in the dimeric assemblage. Only the Cα traces of D2s (cyan) and FGFs (orange) are shown. The decasaccharides are rendered in white sticks. Figure 28 depicts a stereoview of an FoFc electron density map of an FGF2-FGFR1 complex shown in Figure 27 computed after simulated annealing with decasaccharide omitted from the atomic model. The map is computed at 3.0 A resolution and contoured at 1.8 σ. Sugar rings are labeled A through H starting at the non-reducing end ofthe decasaccharide. Atom coloring is as follows: oxygens in red, sulfurs in yellow, nitrogens in blue, and carbons in gray. This figure was constructed using Bobscript (Esnouf, J. Mol. Graph. Model 15, 132-134 (1997). Figure 29 shows a stereoview ofthe detailed interactions between ordered decasaccharide rings (A-F), FGF and FGFR. Only the side chains of interacting residues are shown. The two D2s ofthe adjoining FGFRs are colored cyan and green respectively. Atom coloring is the same as in Figure 27. The carbon atoms in FGFRs have the same coloring as the D2 to which they belong. Dotted lines represent hydrogen bonds.

Figure 30 shows a schematic diagram of interactions between decasaccharide (heparrin), FGF and FGFR in the ternary complex. Only the relevant functional groups and backbone atoms ofthe interacting amino acids are shown. Dashed lines represent hydrogen bonds. Hashed lines represent hydrophobic interactions. The sugar rings of heparin are labeled A through F starting at the non-reducing end. The backbone carbon atoms of heparin are numbered according to IUPAC nomenclature. The type and the number of interacting residues are colored based on the molecule to which they belong.

Figure 31 shows the results of a separation on a Superdex 200 column (Pharmacia) of dimer formation for a set of mixtures of various ratios of homogeneously-sulfated hexasaccharide with purified 1 : 1 FGF1-FGFR2 complex. The following reaction mixture were used: A, control (no hexasaccharide added); B, hexasaccharide:FGFl-FGFR2 complex molar ratio of 0.5: 1 ; C, , hexasaccharide:FGFl-FGFR2 complex molar ratio of 1 : 1 ; D, and hexasaccharide:FGFl-FGFR2 complex molar ratio of 2.85:1. The positions of monomers and dimers are indicated by the letters "M" and "D" respectively. The letter "T" shows the position ofthe tight monomeric ternary 1 :1:1 hexasaccharide: FGFl :FGFR2 complex. The letter "L" shows the position of free FGFl. Figure 32 depicts a molecular surface representation ofthe "two end" model ofthe dimeric 2:2:2 FGF2-FGFR1 -heparin ternary complex. The view is from the top (same view as Fig. 27) looking down into the heparin-binding canyon. The FGF2 surface is shown in orange and D2 in green. Only the first 6 sugar rings ofthe decasaccharides are rendered in ball-and-stick and the non-reducing and reducing ends are labeled.

Figure 33 shows a schematic illustration of a computer based system which can be used for displaying, studying, comparing, manipulating, interpreting and/or extrapolating data from the crystallographic analysis of molecular structures, such as the molecular structures of RPTKs, their ligands and related complexes.

BRIEF DESCRIPTION OF THE CRYSTALLOGRAPHIC ATOMIC STRUCTURAL

COORDINATES The crystallographic structural coordinates are located at the end ofthe section entitled "Examples" and before the claims. Table 1 provides the atomic structure coordinates of crystals of FGFRl -D2-D3 complexed with FGF2 ofthe invention as determined by X-ray crystallography. Table 2 provides the atomic structure coordinates of crystals of FGFRl -D2- D3 complexed with FGFl ofthe invention as determined by X-ray crystallography. Table 4 provides the atomic structure coordinates of crystals of an SCF (1-141) non-covalent homodimer. Table 6 provides the atomic structure coordinates of crystals of a dimeric 2:2:2 FGF2:FGFR1 :heparin ternary complex. The columns (from left to right) in these tables are descriptions ofthe atoms by number and type, amino acid and number containing the atom, the x coordinate, y coordinate, z coordinate, bond connectivity, and temperature factor. All of these parameters are well defined in the art.

DETAILED DESCRIPTION OF THE INVENTION The present invention is directed to the determination and use of three dimensional structures of receptor protein tyrosine kinases. The three dimensional structures of receptor PTKs can facilitate the design and identification of modulators of receptor PTK function.

Protein tyrosine kinases (PTKs) comprise a large and diverse class of enzymes. Schlessinger and Ullrich, 1992, Neuron 9: 383-391. The PTK family is subdivided into members that are receptors and those that are non-receptors. The receptor PTK (RPTK) family contains multiple subfamilies, one of which is the fibroblast growth factor receptor (FGFR) PTK which is a molecule implicated in regulating angiogenesis a well as cellular proliferation and differentiation. Givol and Yayon, 1992, FASEB J. 6 (15): 3362-3369. FGFRl through FGFR4, are known as "high affinity FGFRs," due to the ability to bind fibroblast growth factors with a high affinity. These high affinity FGFRs are characterized by an extracellular ligand-binding domain which comprises three immunoglobulin (IG)-like domains (known as Dl through D3), a single transmembrane helix, and a cytoplasmic domain containing tyrosine kinase activity. See Lee et al, 1989, Science 245: 57-60; Jaye et al, 1992, J. Mol. Biol. 227: 840-851; Johnson & Williams, 1993, Adv. Cancer. Res. 60: 1-41. FGFRs can mediate cellular functions by their role in one or more cellular signal transduction processes. Cellular signal transduction processes comprise a cascade of multiple steps that convert an extracellular signal into an intracellular signal.

RPTK-mediated signal transduction is initiated by binding of a specific extracellular ligand to the extracellular domain, followed by receptor dimerization, and subsequent autophosphorylation ofthe RPTK. Preferred ligands are epidermal growth factors, insulin, platelet-derived growth factors, vascular endothelial growth factors, fibroblast growth factors, hepatocyte growth factors, and neurotrophins. The FGF subfamily presently contains about 18 members, named FGFl through FGFl 8, which bind to FGFRs, and to HSPGs. Those skilled in the art can identify presently unknown members ofthe FGF subfamily by sequence homology to known subfamily members, and/or by the presence of a common protein fold. Each ofthe four high affinity FGFRs binds to a specific subset of FGFs. Ornitz et al, 1996, J. Biol. Chem. 211: 15292-15297.

Once an RPTK is autophosphorylated, the phosphate groups are binding sites for intracellular signal transduction molecules which leads to the formation of protein complexes at the cell membrane. These complexes facilitate an appropriate cellular effect (e.g., cell division, metabolic effects to the extracellular microenvironment) in response to the ligand that began the cascade of events.

RPTKs function as binding sites for several intracellular proteins. Intracellular RPTK binding proteins are divided into two principal groups: (1) those which harbor a catalytic domain; and (2) those which lack such a domain but serve as adapters and associate with catalytically active molecules. Songyang etal., 1993, Cell 72:767-778. SH2 (src homology) domains are common adaptors found in proteins which directly bind to the RPTK. SH2 domains are harbored by RPTK binding proteins of both groups mentioned above. Fantl et al, 1992, Cell 69Λ 13-423; Songyang et al, 1994, Mol. Cell. Biol. 74:2777-2785); Songyang et al, 1993, Cell 72:161-11%; and Koch et al, 1991, Science 252:668-678.

The specificity ofthe interactions between RPTKs and the SH2 domains of their binding proteins is determined by the amino acid residues immediately surrounding the phosphorylated tyrosine residue. Differences in the binding affinities of SH2 domains is correlated with the observed differences in substrate phosphorylation profiles of downstream molecules in the signal transduction process. Songyang et al., 1993, Cell 72:161-11%. These observations suggest that the function of each RPTK is determined not only by its pattern of expression and ligand availability but also by the array of downstream signal transduction pathways that are activated by a particular receptor. Thus, RPTKs provide a controlling regulatory role in signal transduction processes as a consequence of autophosphorylation.

RPTK-mediated signal transduction regulates cell proliferative, differentiation, and metabolic responses in cells. Therefore, inappropriate RPTK activity can result in a wide array of disorders and diseases. These disorders, which are described below, may be treated by the modulators of RPTK function designed or identified by the methods disclosed herein.

The present invention also relates to crystalline polypeptides corresponding to the extracellular domain of receptor tyrosine kinases. Such receptor protein tyrosine kinases are not covalently cross-linked, but are understood to undergo ligand-induced dimerization. Preferably, the crystalline extracellular domains are of sufficient quality to allow for the determination of a three-dimensional X-ray diffraction structure to a resolution of about 1.5 A to about 3 A, and most preferably about 2.8 A. The invention also relates to methods for preparing and crystallizing the polypeptides. The polypeptides themselves, as well as information derived from their crystal structures can be used to analyze and modify tyrosine kinase activity as well as to identify compounds that interact with the extracellular domain. The polypeptides ofthe invention are most preferably designed on the basis ofthe structure of a region in the extracellular domain ofthe RPTKs that contains the ligand binding domain. By way of illustration, FIG. 4 shows the amino acid sequence alignment of the ligand binding D2-D3 domains of human FGFRl, FGFR2, FGFR3, and FGFR4. The applicants have discovered and determined the boundaries ofthe extracellular domain required for crystallization ofthe resulting polypeptide. Surprisingly, these boundaries are very similar to a naturally occurring variant of FGFRl which retains approximatly full ligand binding capacity and specificity. See Johnson etal, Mol. Cell. Biol, 1990 10: 4728-4736.

The resulting crystal structures consists of a unit cell comprising a dimer of two FGFRl D2-D3 domains, each bound to an FGF molecule. The dimeric structure is stabilized by interactions between the two D2 domains, and by interactions between the FGF molecule in one member ofthe dimer and the D2 domain ofthe other member ofthe dimer. These contacts which stabilize the dimeric structure within the crystal are believed to be similar or identical to contacts which result in dimerization and activation of FGFRl in vivo. Thus, the crystal structures ofthe invention provides for the first time a detailed view ofthe events leading to ligand-induced dimerization and activation of RPTKs.

The crystal structures also disclose a possible role for the acid box region ofthe extracellular domain of RPTKs in dimerization and activation. The acid box is a continuous stretch of acidic residues in the linker between Dl and D2. Models inferred from the crystal structures ofthe invention imply that the acid box may interact with the heparin binding region of D2, competing with heparin for binding. Surprisingly, these models imply that loss ofthe ofthe acid box / D2 interaction may permit heparin-induced dimerization and activation of FGFRl in the absence of FGF.

The understanding of dimerization and activation at the atomic level can allow the design of modulators of RPTK function, for example molecules which contribute to or disrupt receptor/ligand binding or intradimer contacts. Such modulators may provide useful treatments for various RPTK diseases.

I. PTK Associated Diseases

PTK-associated diseases and disorders include, but are not limited to, blood vessel proliferative disorders, fibrotic disorders, and mesangial cell proliferative disorders. Blood vessel proliferative disorders refer to angiogenic and vasculogenic disorders generally resulting in abnormal proliferation of blood vessels. The formation and spreading of blood vessels play important roles in a variety of physiological processes such as embryonic development, corpus luteum formation, wound healing and organ regeneration. They also play a pivotal role in cancer development, for example in Kaposi's sarcoma. Other examples of blood vessel proliferation disorders include arthritis, where new capillary blood vessels invade the joint and destroy cartilage, ocular diseases, like diabetic retinopathy, where new capillaries in the retina invade the vitreous, bleed and cause blindness, and von Hippel- Lindau disease (VHL), which is characterized by a predisposition for retinal angiomas, hemangioblastomas in the central nervous system, renal cell carcinomas, pheochromocytomas, and islet cell tumors ofthe pancreas. Conversely, disorders related to the shrinkage, contraction or closing of blood vessels are implicated in such diseases as restenosis.

Fibrotic disorders refer to the abnormal formation of extracellular matrix. Examples of fibrotic disorders include hepatic cirrhosis and mesangial cell proliferative disorders. Hepatic cirrhosis is characterized by the increase in extracellular matrix constituents resulting in the formation of a hepatic scar. Hepatic cirrhosis can cause diseases such as cirrhosis of the liver. An increased extracellular matrix resulting in a hepatic scar can also be caused by viral infection such as hepatitis.

Mesangial cell proliferative disorders refer to disorders brought about by abnormal proliferation of mesangial cells. Mesangial proliferative disorders include various human renal diseases, such as glomerulonephritis, diabetic nephropathy, malignant nephrosclerosis, thrombotic microangiopathy syndromes, transplant rejection, and glomerulopathies. The PDGF-R has been implicated in the maintenance of mesangial cell proliferation. Floege et al, 1993, Kidney International 43:47S-54S.

RPTKs are directly associated with the cell proliferative disorders described above. For example, some members ofthe RPTK family have been associated with the development of cancer. Some of these receptors, like EGFR (Tuzi et al, 1991, Br. J. Cancer 6^'3:227-233; Torp et al, 1992, APMIS 100:713-119) HER2/neu (Slamon et al, 1989, Science 244:707- 712) and PDGF-R (Kumabe et al, 1992, Oncogene 7:627-633) are over-expressed in many tumors and/or persistently activated by autocrine loops. In fact, RPTK over-expression (Akbasak and Suner-Akbasak et al, 1992, J. Neurol. Sci. 777:119-133; Dickson et al, 1992, Cancer Treatment Res. 57:249-273; Korc et al, 1992, J. Clin. Invest. 90:1352-1360) and autocrine loop stimulation (Lee and Donoghue, 1992, J. Cell. Biol 118:1057-1070; Korc et al. , supra; Akbasak and Suner-Akbasak et al. , supra) account for the most common and severe cancers. For example, EGFR is associated with squamous cell carcinoma, astrocytoma, glioblastoma, head and neck cancer, lung cancer and bladder cancer. HER2 is associated with breast, ovarian, gastric, lung, pancreas and bladder cancer. PDGFR is associated with glioblastoma, lung, ovarian, and prostate cancer. The RPTK c-met is generally associated with hepatocarcinogenesis and thus hepatocellular carcinoma. Additionally, c-met is linked to malignant tumor formation. More specifically, c-met has been associated with, among other cancers, colorectal, thyroid, pancreatic and gastric carcinoma, leukemia and lymphoma. Additionally, over-expression ofthe c-met gene has been detected in patients with Hodgkin's disease, Burkitt's disease, and the lymphoma cell line.

The IGF-I RPTK, in addition to being implicated in nutritional support and in type-II diabetes, is also associated with several types of cancers. For example, IGF-I has been implicated as an autocrine growth stimulator for several tumor types, e.g. human breast cancer carcinoma cells (Arteaga et al. , 1989, J. Clin. Invest. 84: 1418- 1423) and small lung tumor cells (Macauley et al, 1990, Cancer Res. 50:2511-2517). In addition, IGF-I, integrally involved in the normal growth and differentiation ofthe nervous system, appears to be an autocrine stimulator of human gliomas. Sandberg-Nordqvist et al, 1993, Cancer Res. 53:2475-2478. The importance ofthe IGF-IR and its modulators in cell proliferation is further supported by the fact that many cell types in culture (fibroblasts, epithelial cells, smooth muscle cells, T-lymphocytes, myeloid cells, chondrocytes, osteoblasts, the stem cells ofthe bone marrow) are stimulated to grow by IGF-I. Goldring and Goldring, 1991, Eukaryotic Gene Expression 7:301-326. A series of recent publications suggest that IGF-IR plays a central role in the mechanisms of transformation and, as such, could be a preferred target for therapeutic interventions for a broad spectrum of human malignancies. Baserga, 1995, Cancer Res. 55:249-252; Baserga, 1994, Cell 79:927-930; Coppola et al, 1994, Mol. Cell. Biol. 7 :4588-4595.

The association between abnormalities in RPTKs and disease are not restricted to cancer, however. For example, RPTKs are associated with metabolic diseases like psoriasis, diabetes mellitus, wound healing, inflammation, and neurodegenerative diseases. EGFR is indicated in corneal and dermal wound healing. Defects in InsulinR and IGFIR are indicated in type-II diabetes mellitus. A more complete correlation between specific RPTKs and their therapeutic indications is set forth in Plowman et al, 1994, DN&P 7:334-339.

The instant invention is directed in part towards designing modulators of RPTK function that could indirectly kill tumors by cutting off their source of sustenance. Normal vasculogenesis and angiogenesis play important roles in a variety of physiological processes such as embryonic development, wound healing, organ regeneration and female reproductive processes such as follicle development in the corpus luteum during ovulation and placental growth after pregnancy. Folkman and Shing, 1992, J. Biological Chem. 267: 10931-34. However, many diseases are driven by persistent unregulated or inappropriate angiogenesis. For example, in arthritis, new capillary blood vessels invade the joint and destroy the cartilage. In diabetes, new capillaries in the retina invade the vitreous, bleed and cause blindness. Folkman, 1987, in: Congress of Thrombosis and Haemostasis (Verstraete, et. al, eds.), Leuven University Press, Leuven, pp.583-596. Ocular neovascularization is the most common cause of blindness and dominates approximately twenty (20) eye diseases.

Moreover, vasculogenesis and/or angiogenesis can be associated with the growth of malignant solid tumors and metastasis. A tumor must continuously stimulate the growth of new capillary blood vessels for the tumor itself to grow. Furthermore, the new blood vessels embedded in a tumor provide a gateway for tumor cells to enter the circulation and to metastasize to distant sites in the body. Folkman, 1990, J. Natl. Cancer Inst. 82:4-6; Klagsbrunn and Soker, 1993, Current Biology 5:699-702; Folkman, 1991, J. Natl, Cancer Inst. 82:4-6; Weidner et al, 1991 , New Engl J. Med. 324: 1 -5.

Several polypeptides with in vitro endothelial cell growth promoting activity have been identified. Examples include acidic and basic fibroblastic growth factor (αFGF, βFGF), vascular endothelial growth factor (VEGF) and placental growth factor. Unlike αFGF and βFGF, VEGF has recently been reported to be an endothelial cell specific mitogen. Ferrara and Henzel, 1989, Biochem. Biophys. Res. Comm. 757:851-858; Vaisman et al, 1990, J. Biol. Chem. 255:19461-19566.

Thus, identifying the specific receptors that bind FGF or VEGF is important for understanding endothelial cell proliferation regulation. Two structurally related receptor PTKs that bind VEGF with high affinity are identified: the flt-1 receptor (Shibuya et al, 1990, Oncogene 5:519-524; De Vries et al, 1992, Science 255:989-991) and the KDR/FLK-1 receptor (VEGFR2), discussed in the U.S. Patent Application No. 08/193,829. In addition, a receptor that binds FGF is identified. Jaye et al, 1992, Biochem. Biophys. Acta 7735:185- 199). Consequently, these RPTKs most likely regulate endothelial cell proliferation.

FGFRs play important roles in angiogenesis, wound healing, embryonic development, and malignant transformation. Basilico and Moscatelli, 1992, Adv. Cancer Res. 59:115-165.

Four high affinity mammalian FGFRs (FGFRl -4) have been described and additional diversity is generated by alternative RNA splicing within the extracellular domains. Jaye et al, 1992, Biochem. Biophys. Acta 7735:185-199. Like other RPTKs, dimerization of FGF receptors is essential for their activation. Soluble or cell surface-bound heparin sulfate proteoglycans act in concert with FGF to induce dimerization (Schlessinger et al, 1995, Cell 53:357-360), which leads to autophosphorylation of specific tyrosine residues in the cytoplasmic domain. Mohammadi et al, 1996, Mol. Cell Biol. 75:977-989.

Mutations in three human FGF receptor genes, FGFRl , FGFR2, and FGFR3, have been implicated in a variety of human genetic skeletal disorders. Mutations in FGFRl and FGFR2 result in the premature fusion ofthe flat bones ofthe skull and cause the craniosynostosis syndromes, such as Apert (FGFR2) (Wilkie et al., 1994, Nat. Genet. 8:269- 274), Pfeiffer (FGFRl and FGFR2) (Muenke et al., 1994, Nat. Genet. 8:269-274),

Jackson- Weiss (FGFR2) (Jabs et al., 1994, Nat. Genet. 5:275-279) and Crouzon (FGFR2) (Jabs et al., 1994, Nat. Genet. 5:275-279) syndromes. In contrast, mutations in FGFR3 are implicated in long bone disorders and cause several clinically related forms of dwarfism including achondroplasia (Shiang et al., 1994, Cell 75:335-342), hypochondroplasia (Bellus et al., 1995, Nat. Genet. 70:357-359) and the neonatal lethal thanatophoric dysplasia

(Tavormina et al., 1995, Nat. Genet. 9:321-328). It has been shown that these mutations lead to constitutive activation ofthe tyrosine kinase activity of FGFR3 (Webster et al., 1996, EMBO J. 75:520-527). Furthermore gene-targeting experiments in mice have revealed an essential role for FGFR3 in developmental bone formation (Deng et al., 1996, Cell 54:911- 921).

Another major role proposed for FGFs in vivo is the induction of angiogenesis (Folkman and Klagsbrun, 1987, Science 235:442). Therefore, inappropriate expression of FGFs or of their receptors or aberrant function ofthe tyrosine kinase activity could contribute to several human angiogenic pathologies such as diabetic retinopathy, rheumatoid arthritis, atherosclerosis and tumor neovascularization (Klagsbrun and Edelman, 1989,

Arteriosclerosis 9:269). Moreover, FGFs are thought to be involved in malignant transformation. Indeed, the genes coding for the three FGF homologues int-2, FGF-5 and hst-1/K-fgf were originally isolated as oncogenes. Furthermore, the cDNA encoding FGFRl and FGFR2 are amplified in a population of breast cancers (Adnane et al., 1991, Oncogene 5:659-663). Over-expression of FGF receptors has been also detected in human pancreatic cancers, astrocytomas, salivary gland adenosarcomas, Kaposi's sarcomas, ovarian cancers and prostate cancers. Evidence, such as the disclosure set forth in copending U.S. Application Serial No. 08/193,829, strongly suggests that VEGF is not only responsible for endothelial cell proliferation, but also is a prime regulator of normal and pathological angiogenesis. See generally, Klagsburn and Soker, 1993, Current Biology 3:699-702; Houck et al, 1992, J. Biol. Chem. 257:26031-26037. Moreover, it has been shown that KDR/FLK-1 and flt-1 are abundantly expressed in the proliferating endothelial cells of a growing tumor, but not in the surrounding quiescent endothelial cells. Plate et al, 1992, Nature 359:845-848; Shweiki et al, 1992, Nature 359:843-845.

The invention is directed to designing and identifying modulators of RPTK functions that could modify the inappropriate activity of a RPTK involved with a clinical disorder. The rational design and identification of modulators of RPTK functions can be accomplished by utilizing the structural coordinates that define a RPTK three dimensional structure.

II. Modulators of PTK functions as Therapeutics for Disease

As a consequence ofthe disorders discussed above, scientists in the biomedical community are searching for modulators of RPTK functions that down-regulate signal transduction pathways associated with inappropriate RPTK activity.

Several small molecule modulators of RPTK functions have been identified which can traverse the cell membrane and do not hydrolyze in acidic environments. For example, bis monocyclic, bicyclic or heterocyclic aryl compounds (PCT WO 92/20642), vinylene- azaindole derivatives (PCT WO 94/14808) l-cyclopropyl-4-pyridyl-quinolones (U.S. Patent No. 5,330,992), styryl compounds (U.S. Patent No. 5,217,999), styryl-substituted pyridyl compounds (U.S. Patent No. 5,302,606), certain quinazoline derivatives (EP Application No. 0 566 266 Al), seleoindoles and selenides (PCT WO 94/03427), tricyclic polyhydroxylic compounds (PCT WO 92/21660), and benzylphosphonic acid compounds (PCT WO 91/15495) are described as RPTK inhibitors.

Although some modulators of RPTK function are known, many of these are not specific for RPTK subfamilies and will therefore cause multiple side-effects as therapeutics. Certain compounds ofthe oxindolinone/ thiolindolinone family, however, are believed to be specific for the FGF receptor subfamily (U.S. Patent Application Serial No. 08/702,232, filed August 23, 1996, invented by Tang et al., entitled "Indolinone Combinatorial Libraries and Related Products and Methods for the Treatment of Disease"). In addition, compounds ofthe oxindolinone/thiolindolinone family are non-hydrolyzable in acidic conditions and can be highly bioavailable. These modulators of RPTK function, however, target the catalytic domain ofthe FGFR subfamily, and thus are not directed towards affecting receptor RPTK dimerization and activation via inteactions in the extracellular domain.

III. Crystalline Tyrosine Kinases

Crystalline RPTKs ofthe invention include native crystals, derivative crystals and co- crystals. The native crystals ofthe invention generally comprise substantially pure polypeptides corresponding to the extracellular domain of an RPTK in crystalline form. In preferred embodiments, the crystals ofthe invention comprise polypeptides corresponding to the extracellular domain of an RPTK in a complex with a ligand.

It is to be understood that the crystalline extracellular domains ofthe invention are not limited to naturally occurring or native extracellular domains. Indeed, the crystals ofthe invention include mutants of native extracellular domains. Mutants of native extracellular domains are obtained by replacing at least one amino acid residue in a native extracellular domain with a different amino acid residue, or by adding or deleting amino acid residues within the native polypeptide or at the N- or C-terminus ofthe native polypeptide, and have substantially the same three-dimensional structure as the native extracellular domain from which the mutant is derived.

Similarly, in certain embodiments in which the extracellular domain is bound to a ligand, the crystals ofthe invention include mutants of native extracellular domains and mutant ligands. As discussed above, mutant ligands can be obtained by replacing at least one amino acid residue in a polypeptide ligand with a different amino acid residue, or by adding or deleting amino acid residues within the native polypeptide or at the N- or C-terminus of the native polypeptide, and have substantially the same three-dimensional structure as the native ligand from which the mutant is derived.

By having substantially the same three-dimensional structure is meant having a set of atomic structure coordinates that have a root-mean-square deviation (rmsd) of less than or equal to about 2 A when superimposed with the atomic structure coordinates ofthe native extracellular domain and/or ligand from which the mutant is derived when at least about 50% to 100% ofthe Cα atoms ofthe polypeptide are included in the superposition. For example, Fig. 3 shows that 68 common Cα atoms in the D2 and D3 regions of FGFRl and telokin, a canonical IG-fold polypeptide, can be superimposed with a rms deviation of 0.8 A.

Amino acid substitutions, deletions and additions which do not significantly interfere with the three-dimensional structure of a polypeptide will depend, in part, on the region ofthe polypeptide where the substitution, addition or deletion occurs. In highly variable regions of the molecule, non-conservative substitutions as well as conservative substitutions may be tolerated without significantly disrupting the three-dimensional structure ofthe molecule. In highly conserved regions, or regions containing significant secondary structure, conservative amino acid substitutions may be preferred. Conservative amino acid substitutions are well-known in the art, and include substitutions made on the basis of similarity in polarity, charge, solubility, hydrophobicity, hydrophilicity and/or the amphipathic nature ofthe amino acid residues involved. For example, negatively charged amino acids include aspartic acid and glutamic acid; positively charged amino acids include lysine and arginine; amino acids with uncharged polar head groups having similar hydrophilicity values include the following: leucine, isoleucine, valine; glycine, alanine; asparagine, glutamine; serine, threonine; phenylalanine, tyrosine. Other conservative amino acid substitutions are well known in the art.

For RPTK extracellular domains obtained in whole or in part by chemical synthesis, the selection of amino acids available for substitution or addition is not limited to the genetically encoded amino acids. Indeed, the mutants described herein may contain non- genetically encoded amino acids. Conservative amino acid substitutions for many ofthe commonly known non-genetically encoded amino acids are well known in the art. Conservative substitutions for other amino acids can be determined based on their physical properties as compared to the properties ofthe genetically encoded amino acids. In some instances, it may be particularly advantageous or convenient to substitute, delete and/or add amino acid residues to a native extracellular domain in order to provide convenient cloning sites in a DNA, such as a cDNA, encoding the polypeptide, to aid in purification ofthe polypeptide, and for crystallization ofthe polypeptide. Such substitutions, deletions and/or additions which do not substantially alter the three dimensional structure of the native tyrosine kinase domain will be apparent to those of ordinary skill in the art. It should be noted that the mutants contemplated herein need not exhibit ligand binding activity. Indeed, amino acid substitutions, additions or deletions that interfere with the ligand binding activity ofthe RPTK extracellular domain but which do not significantly alter the three-dimensional structure ofthe domain are specifically contemplated by the invention. Such crystalline polypeptides, or the atomic structure coordinates obtained therefrom, can be used to identify compounds or molecules that bind to the native domain. These compounds or molecules may affect the activity ofthe native domain.

The derivative crystals ofthe invention generally comprise a crystalline RPTK extracellular domain polypeptide in covalent association with one or more heavy metal atoms. The polypeptide may correspond to a native or a mutated tyrosine kinase domain. Heavy metal atoms useful for providing derivative crystals include, by way of example and not limitation, gold, mercury, etc.

The co-crystals ofthe invention generally comprise a crystalline RPTK extracellular domain polypeptide in association with one or more compounds or other molecules. The association may be covalent or non-covalent. Such molecules include, but are not limited to, ligands, ligand analogs, cofactors, substrates, substrate analogues, inhibitors, activators, allosteric effectors, polypeptides, etc.

rv. Three Dimensional Structure Determination Using X-ray Crystallography

X-ray crystallography is a method of solving the three dimensional structures of molecules. The structure of a molecule is calculated from X-ray diffraction patterns using a crystal as a diffraction grating. Three dimensional structures of protein molecules arise from crystals grown from a concentrated aqueous solution of that protein. The process of X-ray crystallography can include the following steps:

(a) synthesizing and isolating a polypeptide;

(b) growing a crystal from an appropriate solution comprising the polypeptide with or without a compound, modulator, ligand, or ligand analog; and (c) collecting X-ray diffraction patterns from the crystals, determining unit cell dimensions and symmetry, determining electron density, fitting the amino acid sequence of the polypeptide to the electron density, and refining the structure.

Production of Polypeptides

The native and mutated tyrosine kinase domain polypeptides described herein may be chemically synthesized in whole or part using techniques that are well-known in the art (see. e.g.. Creighton, 1983). Alternatively, methods which are well known to those skilled in the art can be used to construct expression vectors containing the native or mutated tyrosine kinase domain polypeptide coding sequence and appropriate transcriptional/translational control signals. These methods include in vitro recombinant DNA techniques, synthetic techniques and in vivo recombination/genetic recombination. See, for example, the techniques described in Maniatis et al., 1989 and Ausubel et al, 1989.

A variety of host-expression vector systems may be utilized to express the RPTK extracellular domain coding sequence. These include but are not limited to microorganisms such as bacteria transformed with recombinant bacteriophage DNA, plasmid DNA or cosmid DNA expression vectors containing the RPTK extracellular domain coding sequence; yeast transformed with recombinant yeast expression vectors containing the RPTK extracellular domain coding sequence; insect cell systems infected with recombinant virus expression vectors (e.g., baculovirus) containing the RPTK extracellular domain coding sequence; plant cell systems infected with recombinant virus expression vectors (e.g.. cauliflower mosaic virus, CaMV; tobacco mosaic virus, TMV) or transformed with recombinant plasmid expression vectors (e.g.. Ti plasmid) containing the RPTK extracellular domain coding sequence; or animal cell systems. The expression elements of these systems vary in their strength and specificities.

Depending on the host/vector system utilized, any of a number of suitable transcription and translation elements, including constitutive and inducible promoters, may be used in the expression vector. For example, when cloning in bacterial systems, inducible promoters such as pL of bacteriophage λ, plac, ptrp, ptac (ptrp-lac hybrid promoter) and the like may be used; when cloning in insect cell systems, promoters such as the baculovirus polyhedrin promoter may be used; when cloning in plant cell systems, promoters derived from the genome of plant cells (e.g.. heat shock promoters; the promoter for the small subunit of RUBISCO; the promoter for the chlorophyll a/b binding protein) or from plant viruses (e.g.. the 35S RNA promoter of CaMV; the coat protein promoter of TMV) may be used; when cloning in mammalian cell systems, promoters derived from the genome of mammalian cells (e.g., metallothionein promoter) or from mammalian viruses (e.g.. the adenovirus late promoter; the vaccinia virus 7.5K promoter) may be used; when generating cell lines that contain multiple copies ofthe receptor PTK extracellular domain DNA, SV40-, BPV- and EBV-based vectors may be used with an appropriate selectable marker. Methods describing methods of DNA manipulation, vectors, various types of cells used, methods of incorporating the vectors into the cells, expression techniques, protein purification and isolation methods, and protein concentration methods are disclosed in detail with respect to the protein PYK-2 in U.S. Patents Nos. 5,837,524, 5,837,815, and PCT publication WO 96/18738, each of which is incorporated herein by reference in its entirety, including all claims, figures, and drawings. Those skilled in the art will appreciate that such descriptions are applicable to the present invention and can be easily adapted to it.

Crystal Growth

Crystals are grown from solutions containing the purified and concentrated polypeptide by a variety of techniques. These techniques include batch, liquid, bridge, dialysis, vapor diffusion, and hanging drop methods. McPherson, 1982, John Wiley, New York; McPherson, 1990, Eur. J. Biochem. 759:1-23; Webber, 1991, Adv. Protein Chem. 47:1-36, incoφorated by reference herein in its entirety, including all figures, tables, and drawings. Generally, the crystals of the invention are grown by adding precipitants to the concentrated solution ofthe polypeptide corresponding to the RPTK extracellular domain, with or without bound compound, modulator, ligand, or ligand analog. The precipitants are added at a concentration just below that necessary to precipitate the protein. Water is removed by controlled evaporation to produce precipitating conditions, which are maintained until crystal growth ceases.

For one ofthe exemplary crystals ofthe invention, it has been found that hanging drops containing about 2.0 μL of RPTK extracellular domain polypeptide with a bound ligand provide crystals suitable for high resolution X-ray structure determination. Preferably, crystals are grown by mixing equal volumes of protein solution (10 mg/mL in 25 mM Tris- HCl, pH 8.5, and 150 mM NaCl) and reservoir buffer (1.6 M (NH₄)₂SO₄, 20% v/v glycerol and 100 mM Tris-HCl, pH 8.5), and suspending a hanging drop ofthe resulting solution over 0.5 mL reservoir buffer at 20°C. In preferred embodiments, the protein solution comprises 10 mg/mL FGFRl D2-D3 domain bound to an FGF2 molecule.

In another exemplary crystal ofthe invention, crystals are grown by mixing one volume of protein solution (1 mg/mL in 25 mM Tris-HCl, pH 8.5, and 150 mM NaCl) with four volumes of reservoir buffer (20% PEG 4000, 0.2 M Li2SO4, and 0.1 M Tris-HCl, pH 8.5), and suspending a hanging drop ofthe resulting solution over 0.5 mL reservoir buffer at 20°C. In preferred embodiments, the protein solution comprises 1 mg/mL FGFRl D2-D3 domain bound to an FGFl molecule.

Those of ordinary skill in the art will recognize that the above-described crystallization conditions can be varied. Such variations may be used alone or in combination, and include polypeptide solutions containing polypeptide concentrations between about 1 mg/mL and about 50 mg/mL, Tris-HCl concentrations between about 10 mM and about 200 mM, dithiothreitol concentrations between about 0 mM and about 20 mM, pH ranges between about 5.5 and about 9.5; and reservoir solutions containing polyethylene glycol concentrations between about 10% and about 50% (w/v), polyethylene glycol molecular weights between about 1000 and about 20,000, (NH )₂SO concentrations between about 0.1 M and about 2.5 M, ethylene glycol or glycerol concentrations between about 0% and about 20% (v/v), bis-Tris concentrations between about 10 mM and about 200 mM, pH ranges between about 5.5 and about 9.5 and temperature ranges between about 0°C and about 25°C. Other buffer solutions may be used such as HEPES buffer, so long as the desired pH range is maintained.

Derivative crystals ofthe invention can be obtained by soaking native crystals in mother liquor containing salts of heavy metal atoms. It has been found that soaking a native crystal in a solution containing about 0.1 mM to about 5 mM thimerosal, 4- chloromeruribenzoic acid or KAu(CN)₂ for about 2 hr to about 72 hr provides derivative crystals suitable for use as isomorphous replacements in determining the X-ray crystal structure ofthe RPTK extracellular domain polypeptide.

Co-crystals ofthe invention can be obtained by soaking a native crystal in mother liquor containing one or more compounds, ligands, or ligand analogs that bind the receptor PTK extracellular domain, as described above, or can be obtained by co-crystallizing the RPTK extracellular domain polypeptide in the presence of one or more binding compounds, ligands, or ligand analogs.

Crystals comprising a polypeptide corresponding to a RPTK extracellular domain complexed with a compound, ligand, or ligand analog can be grown by one of two methods. In the first method, the compound, ligand, or ligand analog is added to the aqueous solution containing the polypeptide corresponding to the RPTK extracellular domain before the crystal is grown. In the second method, the compound, ligand, or ligand analog is soaked into an already existing crystal of a polypeptide corresponding to a RPTK extracellular domain.

Crystalline FGFR Extracellular Domain/FGF complexes

The overall structures ofthe FGFl -FGFRl and FGF2-FGFR2 complexes are similar to the previously determined FGF2-FGFR1 structure (Fig. 5) (Plotnikov et al., 1999). The FGFR ligand-binding domain consists of two Ig-like domains connected by a short linker. The three-dimensional folds of D2 and D3 in both the FGFl -FGFRl and FGF2-FGFR2 structures resemble that ofthe I-set prototype member telokin, in which a β sandwich is formed by two layers of β sheets (Holden et al., 1992). A highly conserved disulfide bond is buried in the hydrophobic core of D2 and D3 and bridges the two β sheets. In both structures, the βC-βC* loop in D3 is disordered (Fig. 5).

The main difference between the structures of FGFl -FGFRl and FGF2-FGFR2 is the conformation ofthe segment connecting βC and βE in D3 (Fig. 5). In the FGF2-FGFR2 structure, this segment is well ordered and interacts with FGF2, while in the FGFl -FGFRl structure, this segment is disordered and is not included in the atomic model. In the previously determined structure of FGF2-FGFR1, this segment is also well ordered and interacts with the ligand (Plotnikov et al., 1999). At the C-terminal end of this segment in the FGF2-FGFR1 structure, a short α helix (αD) has been assigned by PROCHECK (Laskowski et al., 1993). In the present FGF2-FGFR2 structure, the polypeptide chain at the C-terminal end adopts a very similar conformation, but is not assigned as a α helix.

It has previously been reported that both FGFl and FGF2 adopt a β-trefoil fold which consists of three copies of a four-stranded antiparallel β sheet (Fig. 5). Superposition of receptor-bound FGFl and FGF2 with the free FGFl and FGF2 indicates that no significant conformational changes occur in FGFl and FGF2 upon receptor binding. In addition, as with the crystal structures of free FGFl and FGF2, ordered sulfate ions are found in the heparin- binding sites of both FGFl and FGF2. As in the determined crystal structure of FGF2- FGFR1, the ligands in both the FGFl -FGFRl and FGF2-FGFR2 structures interact with residues ofthe receptors in D2, in D3 and in the linker that connects D2 and D3 (Fig. 6). In one illustrative embodiment, the invention provides crystals of FGFRl D2-D3 domain bound to an FGF2 molecule. The D2-D3 domain of this embodiment consists of residues 142-365, and thus is missing the Dl domain, the acid box, and the linker between D3 and the transmembrane helix. Each D2-D3 domain is bound to a single FGF2 molecule. The crystals were obtained by the methods provided in the Examples. The FGFRl D2-D3 / FGF2 crystals, which may be native crystals, derivative crystals or co-crystals, have tetragonal unit cells (i.e.. unit cells wherein a=b≠c) and space group symmetry P4j2ι2. There are two FGFRl D2-D3 / FGF2 complexes in the asymmetric unit, related by an approximate two-fold axis. The unit cell has dimensions of a=b=98.5 A, c=197.0 A and β=90°. The FGF-D2 Interface

The interface between FGF and D2 in both complexes is mainly hydrophobic (Fig. 7 and 8). A solvent-exposed hydrophobic surface in FGF packs against a highly conserved hydrophobic surface at the bottom of D2 in FGFR. In the FGF2-FGFR2 structure, Tyr24, Leul40, and Metl42 in FGF2 make hydrophobic contacts with Alal68 in FGFR2. Leul40, Tyr 103 and the aliphatic portion ofthe Asnl02 side chain in FGF2 make hydrophobic contacts with Pro 170 in FGFR2. Phe31 of FGF2 is engaged in hydrophobic interactions with Leul 66 of FGFR2. Leul 66, Alal 68 and Pro 170 of FGFR2 are located in βA' at the bottom of D2. Val249, located in the C-terminal end of βG in D2, is also in the FGF2-D2 interface and interacts with Leul40 and Metl42 in FGF2. Several hydrogen bonds further fortify the mainly hydrophobic FGF2-D2 interface: the hydroxyl group of Tyr24 in FGF2 forms two hydrogen bonds with backbone atoms of Leul66 and Alal68 in FGFR2, and Tyrl03 makes a hydrogen bond via a water molecule with the backbone of Alal 68.

The observed interactions between FGF2 and FGFR2 in the FGF2-D2 interface are entirely consistent with mutagenesis studies on FGF2. It is demonstrated that individual replacements with alanine of Tyr24, Tyrl03, Leul40 and Metl40, all of which located in the FGF2-D2 interface (Fig. 7), results in a large decrease in FGFRl binding affinity (Springer et al., 1994).

Within each D2-D3 / FGF2 complex ofthe illustrative embodiment, FGF2 interacts extensively with D2, D3, and the linker between the two domains. While a single hydrogen bond is noted between Tyr-24 in FGF2 and Leu- 165 in FGFRl, the majority of interactions between D2 and FGF2 are hydrophobic. For example, hydrophobic contacts can be seen between Tyr- 24 and Met-142 of FGF2 and Ala 167 of D2, between Asn-102, Tyr-103, and Leu-140 of FGF2 and Pro-169 of D2, and between Leu-140 of FGF2 and Val-248 of FGFRl. It is noteworthy that Ala 167, Pro- 169, and Val-248 are conserved amongst FGFRs 1-4, and thus may represent a therapeutically important site in members ofthe FGFR subfamily.

Comparison ofthe FGF-D2 interfaces in the structures of FGF2-FGFR2 and FGF1- FGFR1 reveals a close similarity (Fig. 7 and 8). FGF2 and FGFl differ in only two positions in the FGF-D2 interface: Met 142 in FGF2 is replaced by a homologous hydrophobic residue Leul35 in FGFl, and Asnl02 in FGF2 is substituted by His93 in FGFl. However, this latter substitution may not affect the binding of FGFl to D2, since only the aliphatic portion of this residue interacts with FGFR and not the actual functional group. The FGF-Linker Interface The D2-D3 linker is highly conserved among FGFRs (Fig. 15). The hydrogen bonds between FGFs and the linker region play a critical role in binding of FGFs to FGFRs (Fig. 9 and 10). In the FGF2-FGFR2 structure, an invariant arginine located in the D2-D3 linker, Arg251 (in FGFR2), forms hydrogen bonds with the side chain of Asnl04 and the backbone carbonyl oxygen of Asnl02 (Fig. 9). Indeed, replacement of Asnl04 in FGF2 with an alanine causes a 400-fold reduction in the binding affinity of FGF2 for FGFRl (Zhu et al., 1997), revealing the importance ofthe interaction between Asn 104 and FGFR.

A sequence alignment ofthe 19 available FGFs shows that the majority of FGFs have an asparagine in the position corresponding to Asnl04 of FGF2 (Fig. 17). However, FGF8, FGF 17 and FGFl 8 have a threonine residue at this position, whose side chain is shorter than asparagine. It is predicted that these FGFs will not form a direct hydrogen bond with the key linker arginine residue, and therefore will exhibit lower binding affinity towards FGFRs. Interestingly, FGFl 1, FGF12, FGF13, and FGF14 have a valine in place of Asnl04 of FGF2 (Fig. 17). This substitution is expected to cause a strong decrease in FGFR binding.

The hydrogen bond between Arg251 and FGF2 takes place in a hydrophobic pocket composed ofthe aliphatic side chains of highly conserved Val249 and Pro253 in FGFR2 and Leu98 and Pro 141 in FGF2 (Fig. 9). The proximity to this hydrophobic environment will most likely stabilize this hydrogen bond. Moreover, the intramolecular hydrogen bonds between Arg251 and the invariant Asp283 in FGFR2 and Asnl04 and Tyr 106 in FGF2 serve to restrict the rotational freedom ofthe guanidium group of Arg251 and amide group of Asnl04 (Fig. 9). These interactions may increase the ligand-binding affinity by lowering the entropy of FGF-FGFR complex formation. Indeed, substitution of Tyr 106 with a phenylalanine in FGF2 caused a 5-fold reduction in receptor binding (Zhu et al., 1995). The FGF-linker interfaces in both FGFl -FGFRl and FGF2-FGFR2 structures are highly conserved (Fig. 9 and 10). Moreover, the hydrophobic environment surrounding the critical hydrogen bond between FGFR-invariant linker arginine and FGF is nearly identical in both structures (Fig. 9 and 10). A sequence alignment of all known members ofthe FGF and FGFR families, reveals that residues in FGF and FGFR that constitute the FGF-D2 and FGF- linker interfaces are conserved among the 4 mammalian FGFRs (Fig. 15) and the 19 available FGFs (Fig. 17). Based on our structures and the sequence alignment, we propose that the FGF-D2 and FGF-linker interfaces described above represents a general conserved binding interface for all FGF -FGFR complexes. Interactions between FGF2 and the linker between D2 and D3 in the illustrative embodiment include hydrogen bonds between Asn-102 and Asn-104 of FGF2 with Arg-250 of FGFRl, and a hydrophobic interaction between Leu-98 of FGF2 and Val-248 of FGFRl. Arg-250 is invariant in the FGFR subfamily, and thus may also represent a therapeutically important site. The FGF-D3 Interface

While the FGF-D2 and the FGF-linker interfaces are conserved in FGF-FGFR complexes, a large part ofthe FGF-D3 interface is highly divergent, thus revealing the determinants of FGF-binding specificity. Figures 11-14 depict the interactions between FGF and the upper part ofthe D3 module. These interactions are mediated mainly by the βB'-βC, βC'-βE, and βF-βG loops of FGFRs. While residues in the βB'-βC are highly conserved, the amino acid sequences ofthe βC'-βE and βF-βG loops are significantly divergent among FGFRs (Fig. 16). Notably, alternative splicing occurs at the junction between βC and the βC'-βE loop. Thus, the βC'-βE and βF-βG loops are located in the second half of D3, which is subject to alternative splicing. Interactions of D3 with FGF involve several regions of FGF including the most divergent regions at the N-terminal segment outside ofthe β-trefoil core (prior to βl) and at the central segment consisting of β4 and the β4-β5 loop. In contrast to the FGF-D2 interface which is dominated by hydrophobic interactions, most ofthe interactions in the FGF-D3 interface are mediated by hydrogen bonds. Moreover, many of the hydrogen bonds between FGF and D3 are made via water molecules. The polar nature of this FGF-D3 interface is consistent with the notion that this interface plays a critical role in FGF-FGFR binding specificity. The conserved interactions between FGF2 and the βB'-βC loop in D3 are mediated by four hydrogen bonds (one direct, three water-mediated) between an FGF-invariant glutamic acid residue, Glu96 in FGF2, and FGFR-invariant Gln285 in the βB'-βC loop of D3 (Fig. 9 and 11). A water-mediated hydrogen bond between the side chain of Asnl 04 and the backbone carbonyl oxygen of Asp283 is also made in this interface (Fig. 9). The significance of Glu96 in FGF2 for FGFR binding was confirmed by a 1000-fold reduced receptor binding affinity of an FGF2 mutant containing an alanine in place of Glu96 (Zhu et al., 1995). In contrast to the interface between FGF and the βB'-βC loop, the interactions between FGF and the βC'-βE loop in D3 are highly variable. A major difference between the crystal structures of FGF2-FGFR2 and FGF 1 -FGFRl is the conformation of the βC'-βE segment (Fig. 5). In the FGF2-FGFR2 structure, the βC'-βE loop is well ordered and forms several specific contacts with residues in β4 of FGF2 (Fig. 13). This loop, on the other hand, is disordered in the crystal structure of FGFl -FGFRl (Fig. 5). This difference reflects the lack of interaction between this loop and FGFl and is not the result of crystal packing; this segment is ordered in all the four FGF2-FGFR2 complexes in the unit cell and disordered in both FGFl -FGFRl complexes in the unit cell. As a result of this difference, the total accessible surface area buried in the FGFl -FGFRl complex is 2200A² as compared to 2700A² in the FGF2-FGFR2 complex.

A total of five hydrogen bonds are formed at the interface between FGF2 and the βC- βE segment in the FGF2-FGFR2 structure (Fig. 13). Two hydrogen bonds are formed between the side chain of Gln56 of FGF2 and Asp321 of FGFR2, and two hydrogen bonds are made between the side chain of Glu58 of FGF2 and backbone atoms of Val317 and Asn318 in FGFR2. A fifth hydrogen bond is made between the backbone of Ala57 in FGF2 and the side chain of Asp321 via an ordered water molecule. Hydrophobic contacts between the side chain of Val317 in FGFR2 and the side chains of Tyr73, Val88, and Phe93 in FGF2 fortify this interface (Fig. 13). Mutagenesis experiments support the involvement of both Val88 and Phe93 in receptor binding. Replacement of Val88 and Phe93 with alanine in FGF2 cause a 10-fold and 80-fold reduction in receptor binding affinity, respectively (Zhu et al., 1998). It is possible that the βC'-βE loop exists in several different conformations and that interactions with different FGFs will modulate its secondary structure. In the crystal structures of FGF2-FGFR2 and FGF2-FGFR1, the βC-βE segment forms a small hydrophobic plug by means of interactions between three residues in this region (Ala315, Thr319 and Ile324) along with Ile288 located in βC in D3. It is conceivable that in the unoccupied receptors, the side chains of these residues are not sufficiently hydrophobic to form a stable core. In the occupied receptors, on the contrary, interactions with FGF2 may facilitate the positioning of these hydrophobic residues leading to formation of a more stable structure. In FGFl, the residue corresponding to Gln56 of FGF2 is a serine (Fig. 17), whose side chain is not long enough to form hydrogen bonds with Asp320 in FGFRl . A loss of these hydrogen bonds may increase the flexibility ofthe βC'-βE segment. This region is disordered in the FGF 1 -FGFRl structure (Fig. 5 and Fig. 10).

On the basis ofthe structural analysis described above, it is proposed that FGFl does not engage in any specific contacts with the βC'-βE loop, providing a potential explanation for why FGFl binds indiscriminately to most FGFRs including the various alternatively- spliced forms, thus functioning as a universal ligand for all known FGFRs. The crystal structure of an FGF 1 -FGFR2 complex was recently reported (Stauber et al., 2000). In contrast to the FGF1-FGFR1 structure described here, in the FGF1-FGFR2 structure the βC'-βE loop is ordered and makes several contacts with FGFl. Based on this structure changes in the primary sequence ofthe βC'-βE loop (as a result of alternative splicing) would clearly affect FGFl binding. This structural feature, however, does not agree with the well-documented universal binding characteristics of FGF 1.

The βC'-βE loop of all known FGFRs, irrespective of exon Illb or IIIc, contains a highly conserved potential N-glycosylation site (Asn318 in FGFR2). The results described herein confirm that Asn318 is glycosylated in the extracellular domain of FGFR2 when expressed in insect cells. In the crystal structure of FGF1-FGFR2 (Stauber et al., 2000), the side chain of Asn318 makes two hydrogen bonds with FGF 1. This peculiarity along with the specificity conundrum led us to consider whether the interactions between the βC'-βE loop and FGFl , observed in this structure, could be due to crystal packing and thus not reflect the situation in vivo.

Analysis ofthe relative disposition of D2 and D3 in all the FGF-FGFR structures revealed that the linkage between D2 and D3 is flexible, and the angle between the two domains is not dictated solely by the contacts between the two domains and the ligand. That is, crystal packing also affects the relative disposition ofthe two domains. Although the FGF1-FGFR1 (reported in this manuscript) and FGF1-FGFR2 (Stauber et al., 2000) structures feature a common ligand, superimposition ofthe Cα atoms of D2 between the two structures reveals a 7.8° difference in the relative orientation of D3 and D2. As a consequence, the βC'-βE loop in the FGF1-FGFR2 structure is closer to the ligand, and it is conceivable that the interactions between the βC'-βE loop and FGFl in this structure are the result of crystal packing. In the FGFl -FGFRl structure, the βC'-βE loop is disordered in both complexes in the asymmetric unit, providing two independent instances in which the βC'-βE loop does not engage FGFl. Analysis of the lattice contacts in FGF 1 -FGFR2 structure provides a plausible mechanism by which crystal packing might have contributed to the observed interactions between the βC'-βE loop and FGFl. In this structure, the D2s of two symmetry mates insert into the space between the two D3s ofthe primary dimer, and appear to push the D3s closer to the FGFl molecules. Interactions between FGFR and FGF which Stabilize Dimerization

The D2-D3 / FGF2 dimer observed in the crystal structure of one illustrative embodiment is stabilized by interactions between each FGFR in the dimer, and by interactions between the FGF bound to one FGFR and the other receptor in the dimer. The ligand-receptor contacts which stabilize dimerization are largely weak van der Waals interactions between residues Asp-99, Ser-100, Asn-101, Pro-132, Gly-133, and Leu-138 of FGF2 and Pro-199, Asp-200, Ile-203, Gly-204, Gly-205, Ser-219, and Val-221 of FGFRl. Also noted are hydrogen bonds between Pro-132 of FGF2 andGly-204 of FGFRl, and Lys-26 of FGF2 and Asp-218 of FGFRl.

In contrast, the receptor-receptor contacts which stabilize dimerization include a hydrophobic contact between Ala- 171 residues of each receptor, hydrogen bonds between Lys 172, Thr-173, and Asp-218 of each receptor, and van der Waals interactions between Ala-171 and Lys- 172 of each receptor. The present invention describes a receptor-receptor interface which was not postulated previously, involving residues conserved in the FGFR subfamily. Disruption ofthe contacts which stabilize dimerization, for example by a molecule(s) which prevents the formation of one or more contacts, may provide a means of inhibiting RPTK function. Alternatively, a molecule(s) which further stabilize dimer formation may provide a means of stimulating RPTK function.

Structural Basis for the Role of Alternative Splicing in FGF -Binding Specificity Role ofthe βC'-BE Segment A comparison ofthe amino acid sequences of FGFs and FGFRs in the interface between βC'-βE loop and FGFs shows significant diversity (Fig. 16 and Fig. 17). Moreover, alternative splicing occurs at the end of βC, resulting in major changes in the primary sequence and length ofthe βC'-βE loop. For example, the amino acid sequence ofthe βC'-βE loop in KGFR/FGFR2(IlIb) has seven substitutions and is two amino acids shorter than the corresponding region in FGFR2(IIIc) (Fig. 16). Significantly, the three residues (Ala315, Thr319, and Ile324) in FGFR2(IIIc) that participate in formation ofthe βC'-βE hydrophobic plug are replaced by residues (Ser315, Ser319, and Ala322) in KGFR FGFR2(IIIb) that are less likely to form a hydrophobic plug (Fig. 16). The result of these changes, the βC'-βE loop in KGFR will not be able to interact efficiently with FGF2. This proposal is supported by binding experiments of FGF2 to a mutant FGFR2, in which its βC'-βE loop is replaced with the corresponding region from KGFR. The affinity of FGF2 towards this mutant is reduced by an order of magnitude (Gray et al, 1995). Conversely, insertion ofthe two residues and/or amino acid substitutions in the βC'-βE loop of KGFR did not affect FGFl binding but abolished KGF/FGF7 binding (Wang et al., 1995b). Moreover, replacement ofthe corresponding region in FGFRl (IIIc) conferred upon the mutant receptor the ability to bind KGF (Wang et al., 1999), while wild type FGFRl(IIIc) does not bind KGF/FGF7. These data indicate that there may be steric clashes between KGF/FGF7 and the βC'-βE segment in FGFR2(IIIc) resulting in the reduced affinity of KGF/FGF7 to FGFR2(IIIc). On the contrary, the βC'-βE segment of KGFR/FGFR2(IIIb) may interact more efficiently with KGF/FGF7. The latter hypothesis is supported by the finding that a synthetic peptide derived from KGFR/FGFR2(IIIb) encompassing the βC'-βE segment competes specifically with the binding of KGF/FGF7 to KGFR/FGFR2(fflb) (Bottaro et al., 1993). Final validation of these proposals, however, awaits a crystal structure of KGF/FGF7 in complex with KGFR/FGFR2(IHb). The structural findings described herein are also consistent with the identification of a central segment in KGF/FGF7 (residues 91-110) necessary for specific recognition and activation of KGFR (Reich-Slotsky et al., 1995). This region mainly corresponds to β4 and the β4-β5 loop in FGF2 (Fig. 6), which in the crystal structure of FGF2-FGFR2 make specific contacts with βC'-βE and βF-βG loop in D3, respectively (Figs. 13 and 11, respectively). Taken together, the structural data provide a molecular explanation as to how alternative splicing switches specificity in FGFR2/KGFR system.

Although alternative splicing plays a major role in specificity, similarly spliced variants of FGFRs also exhibit differential binding specificity (Ornitz et al., 1996). It was shown that FGF2 binds strongly to FGFRl (IIIc) and FGFR2(IIIc) but poorly to FGFR3(IIIc) and FGFR4 (Chellaiah et al., 1999; Vainikka et al., 1992). A survey of amino acid sequences of the βC'-βE loop of these receptors shows that the βC'-βE loop of FGFR4 as with

KGFR/FGFR2(IIIb) is two amino acids shorter than the corresponding loop in FGFRl -3 (Fig. 16). Based on the results described herein, it is predicted that this loop in FGFR4 can not efficiently interact with FGF2. This will result in reduced FGF2 binding affinity to FGFR4 as compared to FGFRl. The βC'-βE loop of FGFR3 differs from that of FGFRl by two amino acid substitutions (Fig. 16). Significantly, in FGFR3 the residue corresponding to

Val317 of FGFR2 is an alanine, an amino acid with a smaller side chain than valine (Fig. 16). This will result in a weaker hydrophobic interaction with FGF2, affecting the affinity of FGF2 towards FGFR3. Indeed, when these residues in FGFR3 were replaced with the corresponding residues in FGFRl, the resultant FGFR3 mutant exhibited comparable binding affinity towards FGF2 (Chellaiah et al., 1999). The interactions between FGF and the βC-βE loop in the crystal structure (Fig. 13) provide a molecular explanation for how specificity is regulated by the primary sequence composition ofthe βC'-βE loop. Role ofthe βF-BG Loop The βF-βG loop in D3 also plays an important role in the modulation of FGF binding specificity. In the FGF2-FGFR2 structure, Ser347 of FGFR2, located in βF-βG loop, makes two water mediated-hydrogen bonds with Glu96 and Leu98 of FGF2 (Fig. 11). A water- mediated hydrogen bond between Gly345 in FGFR2 and Gly61 in FGF2 and a direct hydrogen bond between the backbone of Asn346 in FGFR2 and the side chain of Arg60 in FGF2 provide additional contacts in this region (Fig. 11). Residues Arg60 and Gly61 are located in the β4-β5 loop in FGF2 (Fig. 17). Comparison of amino acid sequences shows that FGFs display considerable sequence variation at the position of Arg60 of FGF2. Residue Gly61, on the other hand, is highly conserved in FGFs (Fig. 17). The βF-βG loop is invariant in the Illb and IIIc forms of FGFRs (Fig. 16). However, Gly345 and Ser347 of FGFR2(IIIc) are replaced by Ser342 and Tyr345 in KGFR/FGFR2(fflb). Replacement of Ser347 in FGFR2 by a tyrosine in KGFR/FGFR2(IIIb) may result in steric clashes with FGF2 leading to reduced binding affinity of FGF2 to KGFR/FGFR2(IIIb). This proposal is consistent with ligand binding properties of a double mutant KGFR, in which Tyr345 and Gln348 in KGFR were replaced by serine and isoleucine as in FGFR2. This mutant receptor acquired significant binding affinity towards FGF2 as compared to the parent molecule (Gray et al., 1995). Interestingly, mutation of an invariant asparagine located in the βF-βG (Asn344 in KGFR) to an alanine abolished binding ability of KGFR/FGFR2(IIIb) towards all FGFs tested (Gray et al., 1996). These results are expected based on our FGF-FGFR strcutures: in FGF2-FGFR2 structure the corresponding asparagine (Asn346) makes two intramolecular hydrogen bonds with backbone atoms of Ile348 and Gly349 in FGFR2. These hydrogen bonds play an important role in maintaining the local fold ofthe βF-βG loop. Substitution of Asn346 with an Ala residue will interfere with the folding of this loop resulting in possible steric clashes with all FGFs. Taken together, the structural data provide a plausible molecular explanation for how alternative splicing in D3 regulates FGF binding specificity towards different receptor isoforms. The Role ofthe N-Terminal Segment of FGF In the crystal structures of free FGFl and FGF2, residues upstream of βl are found to be disordered (Eriksson et al., 1991; Blaber et al., 1996; Zhu et al., 1991). However, in the crystal structures ofthe receptor-bound FGFl and FGF2 these residues are ordered and in proximity to D3 of FGFRs (Fig. 12 and 14). In the FGF2-FGFR2 structure, the side chain of Phel7 is located in a shallow hydrophobic pocket in D3 that is formed by Pro286, Ile288 and Val280 (Fig. 12). Moreover, Phel7 forms several hydrogen bonds via backbone atoms with Ser282 and Gln285 in D3. Lys 18 in FGF2 also makes several hydrogen bonds with the side chains of Lys279 and Glu325 and with the backbone of Val280 in D3 (Fig. 12). In agreement with these structural observations, it has been shown that a synthetic peptide consisting of residues 13-18 of FGF2 (prior to βl) competes with the binding of FGF2 to FGFR (Yayon et al., 1993). The amino acids ⁷NYKKPKL¹³ located at the junction between the N-terminal segment and βl in FGFl have been proposed to signal the nuclear accumulation of FGFl that occurs during sustained exposure of cells to FGFl (Imamura et al., 1990). In the FGFl -FGFRl structure, Tyr8 located in this amino acid stretch inserts into a shallow hydrophobic pocket formed by the side chains of Val279, Pro285 and Ile287. The structural data described herein provide a direct role for this region in receptor binding. Deletion mutagenesis experiments support our structural finding. FGFl molecules lacking this amino acid stretch have 250-fold reduced ability to bind FGFR (Imamura et al., 1990). A structure-based sequence alignment of FGFs reveals significant sequence diversity in the segment upstream of βl in FGFs, suggesting that this region may also play a role in determining FGF binding specificity (Fig. 17). In view ofthe interactions between residues prior to βl of FGFs and residues in D3 of

FGFRs, it is possible that additional N-terminal residues that are not included in the currently analyzed FGFl or FGF2 may also play a role in the determining specificity. To test this hypothesis, the crystal structure of full length FGF2 in complex with FGFR2 was determined (data not shown). In this crystal structure, however, all the residues N-terminal to Phel7 are disordered, suggesting that this region does not play a major role in FGFR binding. The significance ofthe N-terminal residues of FGF2 remains unclear. FGFR Mutations Resposible for Human Skeletal Disorders

Mutations in the extracellular domains of FGFRl and FGFR2 have been identified in patients with birth defects involving craniosynostosis (premature fusion ofthe cranial sutures) such as Pfeifer, Crouzon, Jackson- Weiss, and Apert syndromes (reviewed by Naski and Ornitz, 1998; Burke et al., 1998). These mutations cluster in three regions: in the D2-D3 linker, in D3 and in the linker connecting D3 to the transmembrane helix. These mutations can be classified into two groups: (1) Most of these mutations are substitutions of a cysteine with another amino acid or vice versa, resulting in the creation of unpaired cysteines. This leads to ligand-independent dimerization and activation via formation of an intermolecular disulfide bond between receptor molecules. (2) There are mutations that do not involve cysteine substitutions. Nevertheless, it is thought that these mutations must also result in constitutive activation (ligand-independent) ofthe affected receptors because they cause similar disease phenotypes as those mutations that create free cysteines. The precise molecular mechanisms by which these mutations lead to receptor activation are less clear. To understand the molecular bases for the effects of these mutations on FGFR function, we have mapped these mutations onto the three-dimensional structure of FGF2- FGFR2 (Fig. 18). Based on our structural data we predict that many mutations in D3, although not directly involving cysteines, could destabilize the tertiary structure of D3 and disfavor the formation ofthe intra-domain disulfide bridge, thus increasing the likelihood of disulfide bridging between receptor molecules (Fig. 18). Perhaps this notion is best exemplified by the substitution of Trp290 with glycine or arginine. Residue Trp290 is located in the core of D3, adjacent to the disulfide bridge, and replacement of this residue with either ofthe two amino acids will likely reduce the stability of D3 (Fig. 18).

Mutations of two highly conserved residues Ser252 and Pro253 in the D2-D3 linker of FGFR2 are responsible for all the known cases of Apert syndrome. Mutation ofthe equivalent proline in FGFRl (Pro252) has been reported in some cases of Pfeifer syndrome. Based on our structural data we predict that these mutations introduce specific interactions between FGFR and FGF. Indeed, Anderson et al. (1998) have shown that, compared with wild type FGFR2, mutant FGFR2 molecules bearing the Apert mutations exhibit a selective increase in affinity towards FGF2, leading to enhanced signaling where availability of ligand is limiting (Anderson et al., 1998).

As described above, the amino acid stretch between βC fcnd βE plays a critical role in determining specificity. Residue Asp321 makes three hydrogen bonds with FGF2 (Fig. 13). Replacement of Asp321 with alanine, which is detected in some cases of Pfeifer syndrome, will therefore reduce the affinity of FGF2 towards FGFR2. It is conceivable, that this amino acid substitution will increase the affinity of FGFR2 for other members ofthe FGF family. Substitution of Ala315, also located in the βC'-βE loop, with a serine is also associated with Pfeifer syndrome. Residue Ala315 participates in the formation ofthe hydrophobic βC'-βE plug. This substitution can destabilize the hydrophobic plug and may affect ligand binding specificity. Heparin-binding Canyon

In the crystal structure ofthe illustrative embodiment, a highly positively charged "canyon" that continues onto the top side of both ligands is formed by the interaction ofthe two D2 regions in the dimer. The canyon receives its positive potential from ly sines 160, 163, 172, 175, and 177 of FGFRl. This canyon may represent the site of heparin binding. FGF2 also contains a high affinity heparin binding site, consisting of Asn-27, Lys-125, Gln-134, and Arg-120, and heparin increases the apparent affinity of FGF2 for FGFRl. Thus, these residues may represent a useful therapeutic target, for example using a molecule(s) which affects the affinity of a receptor PTK for its ligand.

It has been postulated that heparin traverses this canyon and bridges the two 1 : 1 FGF:FGFR complexes. A recently reported crystal structure of another dimeric assemblage of two FGF 1 :FGFR2 complexes lends additional support to this model (Stauber et al., Proc. Natl. Acad. Sci. USA 97, 49-54 (2000)).

Based on the dimeric structure, manual docking experiments have shown that a maximally active dodecasaccharide perfectly traverses the canyon and engages both the high- and low-affinity heparin binding sites ofthe ligands. In contrast, an octasaccharide placed centrally into the canyon can only interact with the low-affinity heparin binding sites ofthe ligands. A canyon-docked hexasaccharide is unable to interact with any heparin binding sites ofthe ligands, implying that oligosaccharides smaller than an octasaccharide do not possess biological activity. There has been some controversy, however, in determining the minimal length of heparin necessary for FGF signaling. It has been proposed that the shortest biologically active heparin oligosaccharide is an octasaccharide and that an increase in heparin length parallels an increase in biological activity up to a dodecasaccharide. However, other studies report that hexasaccharides are biologically active and that even disaccharides possess biological activity.

The inability of this model to fully reconcile all ofthe previous literature led us to further characterize the role of heparin in FGF signaling. The determination ofthe crystal structure of a ternary FGF2-FGFR1 -heparin complex is described herein. Interactions between heparin, FGF and FGFR provide a molecular basis for the dual role of heparin in augmenting 1 : 1 FGF:FGFR affinity and promoting dimerization of two FGF-FGFR complexes. Moreover, the unexpected 2:2:2 stoichiometry of FGF:FGFR:heparin observed in the structure led us to propose an new model that also accounts for FGF-dependent FGFR activation by short heparin analogs.

While the heparin binding residues in D2 of FGFRs are highly conserved, the heparin binding residues ofthe FGF family are known to display considerable diversity (Faham et al., Curr. Opin. Struct. Biol. 8, 578-586 (1998); Venkataraman et al., Proc. Natl. Acad. Sci. USA 96, 3658-3663 (1999)). Moreover, the βl-β2 heparin binding loop is of variable length in different FGFs. As a result of this heterogeneity, it is likely that different FGFs require heparan sulfates of distinct sulfation and/or length to exert their optimal biological activity. In fact, it has been demonstrated that FGF2 requires 2-O-sulfate for heparin binding but not 6-O-sulfate. In contrast, FGFl requires both sulfate groups to bind to heparin (Ishihara, 1994). Pericellular HSPGs from different cells exhibit significant heterogeneity in sulfation patterns, carbohydrate content and length. These variations could have a profound effect on FGF-FGFR interactions. Moreover, remodeling ofthe extracellular matrix during development may be a means to regulate the biological activities of FGFs.

The heparin binding mode in the present structure disputes the previous findings regarding the minimal length requirement for heparin to promote FGF-FGFR dimerization as well as the stoichiometry of FGF:FGFR:heparin interactions. The tripartite interactions between FGF, FGFR and heparin observed in the crystal structure suggest that heparin hexasaccharides are sufficient to promote receptor dimerization. Therefore, we decided to test the ability of a hexasaccharide to promote dimerization of FGF-FGFR complexes in vitro. Homogeneously-sulfated hexasaccharide was mixed at various molar ratios with a purified 1 : 1 FGFl :FGFR2 complex and the reaction mixtures were analyzed by size exclusion chromatography to quantitate dimerization (Fig. 31). Addition of hexasaccharide at a molar ratio of 0.5:1 hexasaccharide xomplex dimerized half of the FGF1-FGFR2 complexes (Fig. 31, Panel B). Hexasaccharide at a molar ratio of 1 :1 hexasaccharidexomplex led to the quantitative dimerization of all the FGF1-FGFR2 complexes (Fig. 31, Panel C). Excess hexasaccharide reduced dimerization and resulted in the appearance of a peak which elutes slightly earlier than the control (Fig. 31 , Panel D). This peak corresponds to the ternary 1:1 :1 hexasaccharide :FGF1 :FGFR2 complex. It is noteworthy that in the absence of heparin, FGF- FGFR complexes tend to dissociate under size exclusion chromatography conditions, indicating that heparin increases the affinity of FGF for FGFR and stabilizes dimer formation. Hence, the biochemical experiments presented in Fig. 31 support the observed mode of heparin binding in the crystals.

Based upon the crystal structure and supporting biochemical experiments described herein, a new "two end" model by which heparin induces FGF-dependent FGFR dimerization (see Fig. 32) is proposed. According to this model, heparin interacts via its non-reducing ends with both FGF and FGFR and promotes the formation of a stable 1:1:1 FGF:FGFR:heparin ternary complex. A second 1:1:1 FGF:FGFR:heparin ternary complex is then recruited to the first complex via direct FGFR:FGFR contacts, secondary interactions between FGF in one ternary complex and FGFR in the other ternary complex, and indirect heparin-mediated FGFR-FGFR contacts. In the absence of heparin the direct receptor- receptor contacts and secondary ligand-receptor interactions are not sufficient for appreciable dimerization. Clearly, heparin augments direct FGFR-FGFR and secondary FGF-FGFR interactions. The proposed "two end" model presented in this report is consistent with the chemical architecture of heparan sulfate chains, which are linked by the reduced end (01) to the protein core of HSPG. Furthermore, heparan sulfate can be roughly divided into low and high sulfate regions (Gambarini et al., Mol. Cell Biochem. 124, 121-129 (1993)). The low sulfate region is proximal to the protein core. The high sulfate region is located towards the non-reducing end (O4) that corresponds to the non-reducing ends ofthe decasaccharides bound in the center ofthe canyon in our structure. Moreover, the chemical nature ofthe highly sulfated non-reducing ends resemble heparin and are made up of tri-sulfated disaccharide units (IdoA,2S-GlcNS,6S) considered to be the building block of HSPG (Gambarini et al., Mol. Cell Biochem. 124, 121-129 (1993)). In fact, these highly sulfated regions of heparan sulfate have been shown to be the major determinants ofthe potentiating effect of heparan sulfate on FGFl mitogenic activity (Gambarini et al., Mol. Cell Biochem. 124, 121-129 (1993)).

A survey ofthe nature ofthe tripartite interactions between FGF, FGFR and heparin shows that about half of these interactions are mediated through carboxylate, linker and ring oxygens of heparin. Therefore, the results presented here afford a structural basis for the reported ability of certain synthetic non-sulfated heparan-derived di- and rri-saccharides to promote FGF-dependent FGFR activation in vivo (Ornitz et al., 1995). Synthesis of heparin molecules with a homogeneous sulfation pattern is difficult. On the basis ofthe structure presented here, it is possible to design small molecule heparin analogs in which the sulfate groups are replaced with similar functional groups. Thus, our structural studies establish a framework for the rational design of heparin mimetics capable of modulating FGF activity. Given the important roles FGF play in angiogenesis and their biological processes, synthetic heparin agonists and antagonists may have potential therapeutic value.

Crystalline FGFR Extracellular Domain/FGFl complexes In a second illustrative embodiment, the invention provides crystals of FGFRl D2-D3 domain bound to an FGFl molecule. The D2-D3 domain of this embodiment again consists of residues 142-365, and each D2-D3 domain is bound to a single FGFl molecule. The crystals were obtained by the methods provided in the Examples. The FGFRl D2-D3 / FGFl crystals, which may be native crystals, derivative crystals or co-crystals, have triclinic unit cells, and space group symmetry PI. There are two FGFRl D2-D3 / FGFl complexes in the asymmetric unit, related by an approximate two-fold axis. The unit cell has dimensions of about a=62.55 A, b=64.06 A, c=64.14 A, α=93.40°, β=l 11.17°, and γ=97.18°.

Binding interactions between FGFR and FGFl

Within each D2-D3 / FGFl complex ofthe illustrative embodiment, FGFl interacts extensively with D2, D3, and the linker between the two domains. A single hydrogen bond is noted between Tyr-15 in FGFl and Leu-165 in FGFRl, but the majority of interactions between D2 and FGFl are hydrophobic. For example, hydrophobic contacts can be seen between Tyr-15 and Leu-133, and Leu-135 of FGFl and Ala 167 of D2, between Tyr-94, Leu-133, and His-93 of FGFl and Pro-169 of D2, and between Phe-22 of FGFl and Val-248 of FGFRl. These contacts are similar to the contacts described herein for the D2-D3/FGF2 crystal.

Interactions between FGFl and the linker between D2 and D3 in the illustrative embodiment include hydrogen bonds between His-93 and Asn-95 of FGFl with Arg-250 of FGFRl . Again, these contacts are similar to the contacts described herein for the D2- D3/FGF2 crystal. Additionally, several regions of FGFl interact with D3, including Tyr-8, which inserts into a hydrophobic pocket in D3 formed by Val 279, Pro-285, and Ile-287. Additionally, Tyr- 8 participates in a hydrogen bond with Gln-284 of FGFRl . In a region which is diverse amongst the members ofthe FGF family, residues 46, 48-51, and 54 of FGFl form van der Waals contacts with Gln-284, Pro-285, His-286, Gly-344, and Asn-345 of FGFRl Ala-57 of FGF2, and Glu-49 in FGFl forms a hydrogen bond with His-286 of FGFRl . As was described herein for the D2-D3/FGF2 crystals, this latter region may be important in defining the binding specificity of FGFRs, and thus may be a therapeutically important site.

Determining Unit Cell Dimensions and the Three Dimensional Structure of a Polypeptide or

Polypeptide Complex Once the crystal is grown, it can be placed in a glass capillary tube and mounted onto a holding device connected to an X-ray generator and an X-ray detection device. Collection of X-ray diffraction patterns are well documented by those in the art. Ducruix and Geige, 1992, IRL Press, Oxford, England, and references cited therein. A beam of X-rays enter the crystal and then diffract from the crystal. An X-ray detection device can be utilized to record the diffraction patterns emanating from the crystal. Although the X-ray detection device on older models of these instruments is a piece of film, modern instruments digitally record X- ray diffraction scattering.

Methods for obtaining the three dimensional structure ofthe crystalline form of a peptide molecule or molecule complex are well known in the art. Ducruix and Geige, 1992, IRL Press, Oxford, England, and references cited therein. The following are steps in the process of determining the three dimensional structure of a molecule or complex from X-ray diffraction data.

After the X-ray diffraction patterns are collected from the crystal, the unit cell dimensions and orientation in the crystal can be determined. They can be determined from the spacing between the diffraction emissions as well as the patterns made from these emissions. The unit cell dimensions are characterized in three dimensions in units of

Angstroms (one A = 10^"10 meters) and by angles at each vertices. The symmetry ofthe unit cell in the crystals is also characterized at this stage. The symmetry ofthe unit cell in the crystal simplifies the complexity ofthe collected data by identifying repeating patterns. Application ofthe symmetry and dimensions ofthe unit cell is described below. Each diffraction pattern emission is characterized as a vector and the data collected at this stage ofthe method determines the amplitude of each vector. The phases ofthe vectors can be determined using multiple techniques. In one method, heavy atoms can be soaked into a crystal, a method called isomorphous replacement, and the phases ofthe vectors can be determined by using these heavy atoms as reference points in the X-ray analysis. Otwinowski, 1991, Daresbury, United Kingdom, 80-86. The isomorphous replacement method usually requires more than one heavy atom derivative. In another method, the amplitudes and phases of vectors from a crystalline polypeptide with an already determined structure can be applied to the amplitudes ofthe vectors from a crystalline polypeptide of unknown structure and consequently determine the phases of these vectors. This second method is known as molecular replacement and the protein structure which is used as a reference must have a closely related structure to the protein of interest. Naraza, 1994, Proteins 77:281-296. Thus, the vector information from a receptor PTK of known structure, such as those reported herein, are useful for the molecular replacement analysis of another receptor PTK with unknown structure.

Once the phases ofthe vectors describing the unit cell of a crystal are determined, the vector amplitudes and phases, unit cell dimensions, and unit cell symmetry can be used as terms in a Fourier transform function. The Fourier transform function calculates the electron density in the unit cell from these measurements. The electron density that describes one of the molecules or one ofthe molecule complexes in the unit cell can be referred to as an electron density map. The amino acid structures ofthe sequence or the molecular structures of compounds complexed with the crystalline polypeptide may then be fit to the electron density using a variety of computer programs. This step ofthe process is sometimes referred to as model building and can be accomplished by using computer programs such as TOM/FRODO. Jones, 1985, Methods in Enzymology 775:157-171.

A theoretical electron density map can then be calculated from the amino acid structures fit to the experimentally determined electron density. The theoretical and experimental electron density maps can be compared to one another and the agreement between these two maps can be described by a parameter called an R-factor. A low value for an R-factor describes a high degree of overlapping electron density between a theoretical and experimental electron density map.

The R-factor is then minimized by using computer programs that refine the theoretical electron density map. A computer program such as X-PLOR can be used for model refinement by those skilled in the art. Brunger, 1992, Nature 355:472-475. Refinement may be achieved in an iterative process. A first step can entail altering the conformation of atoms defined in an electron density map. The conformations ofthe atoms can be altered by simulating a rise in temperature which will increase the vibrational frequency ofthe bonds and modify positions of atoms in the structure. At a particular point in the atomic perturbation process, a force field, which typically defines interactions between atoms in terms of allowed bond angles and bond lengths, Van der Waals interactions, hydrogen bonds, ionic interactions, and hydrophobic interactions, can be applied to the system of atoms. Favorable interactions may be described in terms of free energy and the atoms can be moved over many iterations until a free energy minimum is achieved. The refinement process can be iterated until the R-factor reaches a minimum value. The three dimensional structure ofthe molecule or molecule complex is described by atoms that fit the theoretical electron density characterized by a minimum R-value. A file can then be created for the three dimensional structure that defines each atom by coordinates in three dimensions. Examples of such structural coordinate files are defined in Tables 1-4 and 6.

V. Stem Cell Factor

Stem cell factor ("SCF") is a growth factor implicated in the stimulation ofthe survival, proliferation, and differentiation of hematopoietic cells. SCF is also known as mast cell growth factor ("MCGF"), steel (SI) factor ("SLF") or kit ligand ("KL"). SCF is believed to be critical for mast cell production and function and to play an important role in the development of melanocytes, germ cells, and intestinal pacemaker cells. SCF is believed to mediate its biological effects by binding to and activating a receptor protein tyrosine kinase designated c-kit (also referred to as SCF receptor ("SCFR"). Like other RPTK ligands, SCF induces dimerization of c-kit followed by trans-autophosphorylation ofthe cytoplasmic protein tyrosine kinase domain leading to subsequent recruitment of signaling proteins, tyrosine phosphorylation of substrates and activation of multiple signaling pathways.

It is believed that stem cell factor ("SCF") can play an important role in hematopoeisis by stimulating the survival, proliferation and differentiation of mast cells, melanocytes and germ cells. SCF has been tested extensively in both animals and human because of its ability to promote hematopoietic recovery. It has been demonstrated that SCF treatments produce an increase in the number of peripheral blood neutrophiles and hematopoietic progenitor cells and modest rises in the numbers of platelets and lymphocytes. SCF, alone or in combination with other cytokines, is used to reduce the hematological damage of chemotherapy. In a separate clinical trial, SCF has also been proven to be effective in enhancing the ability of G-CSF to mobilize peripheral blood hematopoietic progenitor and stem cells. It is believed that these cells can be transplanted to reconstitute the hematopoietic system in patients receiving bone marrow ablative therapy (Nicola et al., Protein Chem. 52, 1-65 (1998)).

SCF exist naturally as membrane anchored and soluble isoforms as a result of alternative RNA splicing and proteolytic processing. The soluble form of SCF has 165 amino acids, but its receptor binding core has been mapped to the first 141 residues (Langley et al., Arch. Biochem. Biophys.311, 55-61 (1994)). SCF functions as a non-covalent homodimer, but under physiological conditions, the majority of SCF is reported to exist as a monomer. Dimerization of SCF is a dynamic process and it may play a regulatory role in the control of SCFR binding affinity and receptor activation. Comparison of SCF with other Growth Factors

SCF belongs to the short-chain helical cytokine family (Bazan, 1991 ; Rozwarski et al., 1994), but its resemblance to the other cytokines is limited only to the overall fold. The primary structures exhibit very weak similarity and sequences can be aligned only by comparison ofthe secondary structures (Fig. 20). The structure of SCF is most similar to the structure of M-CSF (Pandit et al., Science 258, 1358-1362 (1992)). The core four helix bundles ofthe two proteins superimpose relatively well, with r.m.s. deviation of 1.98 A for the alpha-C atoms. However, upon superimposition ofthe helices, the two beta-strands deviate significantly. Two loops in SCF, residues 29 to 41 and residues 90 to 98, extrude more than those of M-CSF. At the dimer interface, the SCF loop from residue 61 to 72 also extrudes further away from the core and packs against the same loop from the second protomer. The x-ray crystallography work described herein suggests that there is more contact between the two protomers of SCF as compared to the contact between the two M- CSF protomers. Furthermore, M-CSF is a covalent homodimer linked by an intermolecular disulfide bond whereas SCF is a noncovalent homodimer. Flt3 ligand is also a noncovalent homodimer, but it has an extra intramolecular disulfide bond as does M-CSF. Nevertheless, the structure of fit 3 ligand (Hannum et al., Nature 368, 643-648 (1994)) can be predicted with reasonable confidence based upon the crystal structures of SCF described herein together with the previously described crystal structure of M-CSF (Pandit et al., Science 258, 1358- 1362 (1992)).

In contrast to the disulfide linked PDGF and M-CSF homodimers, two other ligands ofthe same family of receptor tyrosine kinases, SCF functions as a non-covalent homodimer (Pandit et al., Science 258, 1358-1362 (1992)). It has been shown that the bivalency of SCF is the sole driving force responsible for dimerization ofthe extracellular ligand binding domain of c-kit. Hence analysis ofthe molecular interactions that control SCF-dimer formation are critical for understanding the mechanism of activation of c-kit.

It is known that dimerization of SCF is sensitive to pH and salt concentration changes. This property is likely due to the fact that the interface is formed in part by polar interactions via salt bridges at the periphery and by a water molecule-mediated hydrogen bonds among buried polar residues at the core ofthe interface. In an attempt to identify residues that play a role in SCF dimerization, a Phe63Cys mutant was generated and characterized for receptor binding activity (Hsu et al., J. Biol. Chem. 272, 6406-6415 (1997)). It was demonstrated that this mutation led to the formation of a covalent SCF dimer. However, the mutant SCF dimer was biologically inactive. The structure ofthe SCF interface described herein provides a plausible explanation for the lack of activity of this mutant, (see Fig. 21). In the structure, the shortest distance between the side chains ofthe two symmetry related Phe63 is about 8 A with the well-coordinated water molecule between them. It is impossible to create a disulfide bond between these two residues without disrupting the secondary and tertiary structures of the SCF dimer. Domain Swapping and the Covalent Dimer of SCF

Recombinant SCF is expressed in E. coli as inclusion bodies in a denatured form and an active SCF protein is produced by a procedure involving refolding and oxidation. It has previously been reported that a small fraction ofthe refolded-oxidized protein is a covalent disulfide linked form of SCF. Interestingly, the covalent SCF dimer has bben reported to bind to c-kit with slightly reduced affinity but was more potent in stimulation of hematopoietic cells. Comparison ofthe secondary and tertiary structures by spectroscopic methods demonstrated that the covalent dimer is indistinguishable from the non-covalent dimer (Lu et al., J. Biol. Chem. 277, 11309-11316 (1996)). Surprisingly, the disulfide linkages ofthe covalent dimer were found to be identical to those in the non-covalent dimer except that the disulfide linkages in the variant protein were intermolecular. That is, Cys4 and Cys43 from one protomer form disulfide bonds with Cys89 and Cys 138, respectively, of the second protomer. It was thus proposed that the covalent dimer could be formed by a three-dimensional domain swapping of helices alphaA and alphaD between the two monomers (Lu et al, J. Biol. Chem. 277, 11309-11316 (1996)). A close examination ofthe three-dimension structure of SCF reported herein shows that the C2 symmetry of the dimer may allow these helices to be swapped between the protomers while preserving the overall structure and identical surface at the tails of each protomer. Figure 23 shows a model generated by swapping helices alphaA and alphaD between the two protomers. Interestingly, the interactions at the core between the helices from the original dimer are preserved in the swapped model while the loops around the C2 axis and the orientation ofthe strands have to be adjusted. The disulfide pairs are identical in both forms except that they are intramolecular in the non-covalent dimer and intermolecular in the covalent dimer. It is worth noting that other four helix bundle cytokines such as L-5, IL-10 and IFN- are reported to form similar covalent interdigitated dimers naturally. In IL-5, helix alphaD and strand 2 of one protomer, together with helices alphaA, alphaB, alphaC and strand 1 from the other protomer, form one domain ofthe two-domain dimer. Indeed, because ofthe symmetric nature ofthe structure, it was possible to generate monomeric IL-5 mutants (Dickason et al., Nature 379, 652-655 (1996); Dickason et al., J Mol Med 74, 535-546 (1996); Edgerton et al., J. Biol. Chem. 272, 20611-20618 (1997)). By the same token, new type interdigitated covalent SCF dimers could be formed by introducing mutations in the loops between helix αA and strand 1 and between 2 and helix αD that favor the covalent dimer structure. These similarities in fold and dimeric symmetry among the helical cytokines probably reflect their common evolutionary origin. Three-dimensional domain swapping is considered to be a general mechanism for the regulation of oligomer assembly, that is oligomers are formed from stable monomers by exchanging domains during evolution or under controlled laboratory conditions (Bennett et al., 1995). It has been suggested that under normal physiological conditions, the majority of soluble SCF exists as monomers. The balance between SCF monomers and dimers may be linked to the physiological requirement for activation of c-kit expressed on target cells in vivo. For therapeutic purpose, however, the more potent disulfide-linked dimer is generally preferred because it can be administered at low doses to avoid significant mast cell activation while stimulating hematopoietic recovery (Nocka et al., Blood 90, 3874-3883 (1997)). Receptor Binding Region on SCF

SCF dimer are known to bind soluble or membrane forms of c-kit with high affinity and specificity. The binding of SCF to c-kit was analyzed by biochemical methods, by employing site-directed mutagenesis and by epitope mapping with site-specific anti-c-kit antibodies. It was reported that deletions of residues 1 to 3 from the N-terminus reduced the binding of SCF to c-kit by approximately 50%. Deletion of Cys4 inactivated SCF, whereas deletion of Cysl38 and additional residues form the C-terminus only compromised SCF activity. Moreover, an SCF double mutant at Cys43Ala and Cysl38Ala, which eliminate one pair of disulfide bonds, resulted in a partially active SCF as well. These experiments demonstrated that the N-terminus of SCF and the integrity ofthe Cys4-Cys89 disulfide bond are crucial for full CSF activity.

By analyzing the activities of a variety of SCF/M-CSF chimeric proteins, it has been shown that Argl21, Asp 124, Lys 127 and Asp 128 are essential for SCF activity (Matous et al., Blood 88, 437-444 (1996)). Moreover, by using antibodies that neutralize different epitopes on SCF, it has been demonstrated that the regions flanked by amino acids 61 to 65 and 91 to 95 are also essential for SCF activity (Mendiaz et al., Eur. J. Biochem. 239, 842- 849 (1996)). In general the regions mapped by biochemical methods are located in close proximity at the tail region of each SCF protomer. This region contains a deep crevice at the end of alphaC formed by side chains ofthe hydrophobic residues Phel02, Leu98, Pro34, Tyr32, and by the Cys43-Cysl38 disulfide bridge (see Fig. 24). Next to the crevice, there are three charged patches; a positively charged patch (Arg5, Arg7, and Lysl27) followed by a negatively charged patch (Asp84, Asp85, Glu88, and Glu92) and then by an additional positively charged patch (Lys91, Lys99, LyslOO and Lysl03). Figure 24 shows the locations ofthe positively charged and negative charged patches as well as the hydrophobic crevice. This surface may function as a receptor binding site with the charged interactions providing anchor and specificity for ligand receptor interactions and the hydrophobic interactions providing enthalpy to complex formation. While human and rodent SCF are highly conserved, the charged patches that may function as part of receptor binding regions are quite divergent (see Fig. 25). Residues Arg5 and Arg7 in the first positively charged patch ofthe human SCF are replaced by glycine and proline residues in rodents, respectively. In the second positively charged patch, residues LyslOO and Lys91 are substituted by glutamate residues in both mouse and rat. These changes could account for the difference in the binding affinity of human and murine SCF to the human c-kit that has been reported.

Natural and CHO-cell derived recombinant SCF are glycosylated on multiple asparagine, serine and threonine residues. The receptor binding properties of glycosylated SCF are consistent with the assignment of SCFR binding region shown in Fig. 24. There are four putative asparagine glycosylation sites in the functional core of SCF: Asn65, Asn72, Asn93 and Asnl20. Asn72 is not glycosylated probably because its side chain is buried in the dimer interface. However, the side chains of Asnl20, Asn65, and Asn93 remain accessible to the solvent in the structure and are indeed glycosylated to different extent. Asn 120 is always glycosylated but this does not affect the binding of SCF to c-kit. In contrast, Asn65 and Asn93 are glycosylated in some, but not all, SCF molecules.

Importantly, glycosylation of these asparagine residues has been reported to have an adverse effect on SCF binding to SCFR. The structure described herein provides possible explanations for the adverse effect of glycosylation of these residues on the activity of SCF. The glycosylation of Asn93 may hinder SCF binding to c-kit as this residue is located very close to the acidic patch and to the hydrophobic crevice. On the other hand, Asn65 is located close to the dimer interface and glycosylation of this residue may interfere with SCF dimerization.

Model for SCF:SCFR Complex

The extracellular ligand binding domains of several receptor tyrosine kinases contain multiple Ig-like domains. For instance, the extracellular domains of FGF receptors contain three Ig-like domains while the extracellular domain of PDGF-receptor family to which c-kit belongs is composed of five Ig-like domains. Similarly, the extracellular domain ofthe

VEGF-receptor has been reported to contain seven Ig-like domains. Although the ligands of these receptors are very diverse, the ligand binding regions in these three families of receptors have been mapped to Ig-like domains two and three (see, e.g., Plotnikov et al., Cell 98, 641-650 (1999)). The determination ofthe structures ofthe ligand binding domains of FGF and VEGF receptors demonstrated that FGF and VEGF bind differently to their respective receptors. In the FGF:FGFR complex the two receptors are packed side by side to one face and the ligands occupy the second face. On the other hand, the two VEGFR bind to the far ends ofthe VEGF-dimer creating an inverted "A" shaped complex with the ligand representing the cross bar in the "capital A". Since SCF functions as a dimer, SCF binding to c-kit would be expected to resemble the structure which has been reported for the VEGF :VEGFR complex.

The x-ray crystal structure ofthe SCF dimer was used to build a model of SCF:c-kit complex formation and dimerization. Using the structure of FGFR as a template, a model for Ig-like domains 2-3 as well as 4-5 of c-kit was developed. Ig-like domains 2 and 3 were then docked to the proposed SCF binding surface adopting the mode of FGFR binding to FGF2 (Plotnikov et al., Cell 98, 641-650 (1999)). In addition, the orientation of Ig-like domains 4 and 5 was adjusted to allow for interactions between domain 4 in the complex as suggested by previous biochemical studies (Blechman et al., Cell 80, 103-113 (1995)); see Fig. 26). c-kit belongs to the same family of RTKs that also includes M-CSFR, PDGFR alpha, PDGFR alpha and lt3. Comparison of their primary structures shows that these RTKs are much more conserved than their ligands. Indeed, the structures of PDGF-A and PDGF-B are dramatically different from the structures of M-CSF and SCF and probably also flt3 ligand. The similarity ofthe RTKs is also reflected in the chromosomal localizations of their human and murine genes (Kondo et al., Gene 208, 297-305 (1998)). It is thought that this family of RTKs has evolved from a common ancestral gene that undergone several gene-duplication events. It is worth noting that RTKs that bind to and are activated by ligands with structures of four-bundle helix (i.e., M-CSF, SCF) are primarily involved in the control of hematopoeisis, whereas other members of this family of RTKs exhibit broader expression pattern and are involved in the regulation of growth and development of several tissues and organs. Determination ofthe three dimensional structure of SCF would facilitate the determination ofthe structure of SCF in complex with the extracellular domain of c-kit, and enable the design and production of more potent forms of therapeutic SCF analogues. With the detailed structural information described herein, it may now be possible to design novel

SCF variants with increased therapeutic potency.

VI. Uses ofthe Crystals and Atomic Structure Coordinates

The crystals ofthe invention, and particularly the atomic structure coordinates obtained therefrom, have a wide variety of uses. For example, the crystals described herein can be used as a starting material in any ofthe art-known methods of use for RPTKs. Such methods of use include, for example, identifying molecules that bind to the native or mutated extracellular domain of RPTKs. The crystals and structure coordinates are particularly useful for identifying compounds which are modulators of RPTK function as an approach towards developing new therapeutic agents (see, e.g., Levitzki and Gazit, 1995, Science 257:1782-8). The structure coordinates described herein can also be used as phasing models for determining the crystal structures of additional native or mutated receptor PTK extracellular domains, as well as the structures of co-crystals of such domains complexed with molecules such as ligands, ligand analogs, inhibitors, activators, agonists, antagonists, polypeptides, and other molecules. The structure coordinates, as well as models ofthe three-dimensional structures obtained therefrom, can also be used to aid the elucidation of solution-based structures of native or mutated receptor PTK extracellular domains, such as those obtained via NMR. Thus, the crystals and atomic structure coordinates ofthe invention provide a convenient means for elucidating the structures and functions of receptor tyrosine kinases. For purposes of clarity and discussion, the crystals ofthe invention will be described by reference to specific FGFRl D2-D3 / FGF2 and FGFRl D2-D3 / FGFl exemplary crystals. Those skilled in the art will appreciate that the principles described herein are generally applicable to crystals ofthe extracellular domain of any receptor tyrosine kinase, including but not limited to receptor PTKs such as are PDGFR, EGFR, VEGFR, HGFR, neurotrophinR, HER2, HER3, HER4, InsulinR, IGFR, CSFIR, FLK, KDR, VEGFR2, CCK4, MET, TRKA, AXL, TIE, EPH, RYK, DDR, ROS, RET, LTK, ROR1, MUSK, members of the FGFR family, such as FGFRl, FGFR2, FGFR3, and FGFR4, and orphan receptor PTKs. VII. Structure Determination for PTKs with Unknown Structure Using Structural Coordinates Structural coordinates, such as those set forth in Tables 1 -4 and 6 can be used to determine the three dimensional structures of RPTKs with unknown structure. The methods described below can apply structural coordinates of a polypeptide with known structure to another data set, such as an amino acid sequence, X-ray crystallographic diffraction data, or nuclear magnetic resonance (NMR) data. Preferred embodiments ofthe invention relate to determining the three dimensional structures of receptor PTKs and related polypeptides. These include receptor PTKs such as are PDGFR, EGFR, VEGFR, HGFR, neurotrophinR, HER2, HER3, HER4, InsulinR, IGFR, CSFIR, FLK, KDR, VEGFR2, CCK4, MET, TRKA, AXL, TIE, EPH, RYK, DDR, ROS, RET, LTK, ROR1, MUSK, members ofthe FGFR family, such as FGFRl, FGFR2, FGFR3, and FGFR4, and orphan receptor PTKs. Structures Using Amino Acid Homology

Homology modeling is a method of applying structural coordinates of a polypeptide of known structure to the amino acid sequence of a polypeptide of unknown structure. This method is accomplished using a computer representation ofthe three dimensional structure of a polypeptide or polypeptide complex, the computer representation of amino acid sequences ofthe polypeptides with known and unknown structures, and standard computer representations ofthe structures of amino acids. Homology modeling comprises the steps of

(a) aligning the amino acid sequences ofthe polypeptides with and without known structure;

(b) transferring the coordinates ofthe conserved amino acids in the known structure to the corresponding amino acids ofthe polypeptide of unknown structure; (c) constructing structures ofthe rest ofthe polypeptide; and (d) refining the subsequent three dimensional structure. One skilled in the art recognizes that conserved amino acids between two proteins can be determined from the sequence alignment step in step (a).

The above method is well known to those skilled in the art. Greer, 1985, Science 228, 1055. Blundell et al., 1988, Eur. J. Biochem. 772, 513. A computer program currently utilized for homology modeling by those skilled in the art is the Homology module in the Insight II modeling package distributed by Molecular Simulations Inc.

Alignment ofthe amino acid sequence is accomplished by first placing the computer representation ofthe amino acid sequence of a polypeptide with known structure above the amino acid sequence ofthe polypeptide of unknown structure. Amino acids in the sequences are then compared and groups of amino acids that are homologous (e.g., amino acid side chains that are similar in chemical nature - aliphatic, aromatic, polar, or charged) are grouped together. This method will detect conserved regions ofthe polypeptides and account for amino acid insertions or deletions. Once the amino acid sequences ofthe polypeptides with known and unknown structures are aligned, the structures ofthe conserved amino acids in the computer representation ofthe polypeptide with known structure are transferred to the corresponding amino acids ofthe polypeptide whose structure is unknown. For example, a tyrosine in the amino acid sequence of known structure may be replaced by a phenylalanine, the corresponding homologous amino acid in the amino acid sequence of unknown structure.

The structures of amino acids located in non-conserved regions are to be assigned by either using standard peptide geometries or molecular simulation techniques, such as molecular dynamics. The final step in the process is accomplished by refining the entire structure using molecular dynamics and/or energy minimization.

The homology modeling method is well known to those skilled in the art and has been practiced using different protein molecules. For example, the three dimensional structure of the polypeptide corresponding to the catalytic domain of a serine/threonine protein kinase, myosin light chain protein kinase, was homology modeled from the cAMP-dependent protein kinase catalytic subunit. Knighton et /., 1992, Science 255:130-135.

Structures Using Molecular Replacement

Molecular replacement is a method of applying the X-ray diffraction data of a polypeptide of known structure to the X-ray diffraction data of a polypeptide of unknown sequence. This method can be utilized to define the phases describing the X-ray diffraction data of a polypeptide of unknown structure when only the amplitudes are known. X-PLOR is a commonly utilized computer software package used for molecular replacement. Briinger, 1992, Nature 355:472-475. AMORE is another program used for molecular replacement. Navaza, 1994, Acta Crystallogr. A50: 157-163. Preferably, the resulting structure does not exhibit a root-mean-square deviation of more than 3 A.

A goal of molecular replacement is to align the positions of atoms in the unit cell by matching electron diffraction data from two crystals. A program such as X-PLOR can involve four steps. A first step can be to determine the number of molecules in the unit cell and define the angles between them. A second step can involve rotating the diffraction data to define the orientation ofthe molecules in the unit cell. A third step can be to translate the electron density in three dimensions to correctly position the molecules in the unit cell. Once the amplitudes and phases ofthe X-ray diffraction data are determined, an R-factor can be calculated by comparing electron diffraction maps calculated experimentally from the reference data set and calculated from the new data set. An R-factor between 30-50% indicates that the orientations ofthe atoms in the unit cell are reasonably determined by this method. A fourth step in the process can be to decrease the R-factor to roughly 20% by refining the new electron density map using iterative refinement techniques described herein and known to those or ordinary skill in the art. Structures Using NMR Data

Structural coordinates of a polypeptide or polypeptide complex derived from X-ray crystallographic techniques can be applied towards the elucidation of three dimensional structures of polypeptides from nuclear magnetic resonance (NMR) data. This method is used by those skilled in the art. Wuthrich, 1986, John Wiley and Sons, New York: 176- 199; Pflugrath et al, 1986, J. Molecular Biology 759:383-386; Kline et al, 1986, J. Molecular Biology 759:377-382. While the secondary structure of a polypeptide is often readily determined by utilizing two-dimensional NMR data, the spatial connections between individual pieces of secondary structure are not as readily determinable. The coordinates defining a three-dimensional structure of a polypeptide derived from X-ray crystallographic techniques can guide the NMR spectroscopist to an understanding of these spatial interactions between secondary structural elements in a polypeptide of related structure.

The knowledge of spatial interactions between secondary structural elements can greatly simplify Nuclear Overhauser Effect (NOE) data from two-dimensional NMR experiments. Additionally, applying the crystallographic coordinates after the determination of secondary structure by NMR techniques only simplifies the assignment of NOEs relating to particular amino acids in the polypeptide sequence and does not greatly bias the NMR analysis of polypeptide structure. Conversely, using the crystallographic coordinates to simplify NOE data while determining secondary structure ofthe polypeptide would bias the NMR analysis of protein structure.

As the analysis of polypeptide structure by NMR methods is a relatively new technique, the use of structural coordinates defining an RPTK structure will most likely be utilized more frequently in the near future. As the method progresses, the three dimensional structure analysis of polypeptides ofthe same size as an RPTK extracellular domain will become more frequent.

VIII. Structure-Based Design of Modulators of PTK Function Utilizing Structural Coordinates

Structure-based modulator design and identification methods are powerful techniques that can involve searches of computer data bases containing a wide variety of potential modulators and chemical functional groups. The computerized design and identification of modulators is useful as the computer data bases contain more compounds than the chemical libraries, often by an order of magnitude. For reviews of structure-based drug design and identification see Kuntz et al, 1994, Ace. Chem. Res. 27:117; Guida, 1994, Current Opinion in Struc. Biol. 4: 777; Colman, 1994, Current Opinion in Struc. Biol. 4: 868.

The three dimensional structure of a polypeptide defined by structural coordinates can be utilized by these design methods. Preferably, the structural coordinates of Table 1 or Table 2 can be utilized by this method. In addition, the three dimensional structures of RPTKs determined by the homology, molecular replacement, and NMR techniques described herein can also be applied to modulator design and identification methods. Thus, the structures of receptor PTKs, such as are PDGFR, EGFR, VEGFR, HGFR, neurotrophinR, HER2, HER3, HER4, InsulinR, IGFR, CSFIR, FLK, KDR, VEGFR2, CCK4, MET, TRKA, AXL, TIE, EPH, RYK, DDR, ROS, RET, LTK, ROR1, MUSK, members ofthe FGFR family, such as FGFRl, FGFR2, FGFR3, and FGFR4, and orphan receptor PTKs, can be utilized by the methods described herein.

Design by Searching Molecular Data Bases One method of rational modulator design searches for modulators by docking the computer representation of compounds from a data base of molecules. Publicly available data bases include: a) ACD from Molecular Designs Limited b) NCI from National Cancer Institute c) CCDC from Cambridge Crystallographic Data Center d) CAST from Chemical Abstract Service e) Derwent from Derwent Information Limited f) Maybridge from Maybridge Chemical Company LTD g) Aldrich from Aldrich Chemical Company h) Directory of Natural Products from Chapman & Hall

One such data base (ACD distributed by Molecular Designs Limited Information Systems) contains, for example, 200,000 compounds that are synthetically derived or are natural products. Methods available to those skilled in the art can convert a data set represented in two dimensions to one represented in three dimensions. These methods are enabled by such computer programs as CONCORD from Tripos Associates or DB-Converter from Molecular Simulations Limited. Multiple methods of structure-based modulator design are known to those in the art. Kxmtz et aL, 1982, J. Mol Biol. 162: 269; Kuntz et α/., 1994, Ace. Chem. Res. 27: 117; Meng et α/., 1992, J. Compt. Chem. 13: 505; Bohm, 1994, J Comp. Aided Molec. Design 8: 623. A computer program widely utilized by those skilled in the art of rational modulator design is DOCK from the University of California in San Francisco. The general methods utilized by this computer program and programs like it are described in three applications below. More detailed information regarding some of these techniques can be found in the Molecular Simulations User Guide, 1995. A typical computer program used for this purpose can comprise the following steps:

(a) remove an existing compound, ligand, or ligand analog from the protein;

(b) dock the structure of another compound, ligand, or ligand analog into the compound binding site using the computer program (such as DOCK) or by interactively moving the compound into the active-site; (c) characterize the space between the compound and the binding site atoms;

(d) search libraries for molecular fragments which (i)can fit into the empty space between the compound and the active-site, and (ii) can be linked to the compound; and

(e) link the fragments found above to the compound and evaluate the new modified compound. Part (c) refers to characterizing the geometry and the complementary interactions formed between the atoms ofthe RPTK and the compound, ligand, or ligand analog. A favorable geometric fit is attained when a significant surface area is shared between the compound and RPTK atoms without forming unfavorable steric interactions.

One skilled in the art would note that the method can be performed by skipping parts (d) and (e) and screening a data base of many compounds.

Structure-based design and identification of modulators of RPTK function can be used in conjunction with assay screening. As large computer data base of compounds (around 10,000 compounds) can be searched in a matter of hours, the computer based method can narrow the compounds tested as potential modulators of RPTK function in cellular assays.

The above descriptions of structure-based modulator design are not all encompassing and other methods are reported in the literature: ( 1 ) CAVEAT: Bartlett et al. , 1989, in "Chemical and Biological Problems in Molecular Recognition", Roberts, S.M.; Ley, S.V.; Campbell, M.M. eds.; Royal Society of Chemistry: Cambridge, ppl82-196.

(2) FLOG: Miller et al., 1994, J. Comp. Aided Molec. Design 5:153. (3) PRO Modulator: Clark et al, 1995, J. Comp. Aided Molec. Design 9:13.

(4) MCSS: Miranker and Karplus, 1991, Proteins: Structure, Function, and Genetics 77:29.

(5) AUTODOCK: Goodsell and Olson, 1990, Proteins: Structure, Function, and Genetics 5:195. (6) GRID: Goodford, 1985, J. Med. Chem. 25:849.

Design by Modifying Compounds in Complex with RPTKs

Another way of identifying compounds, ligands, or ligand analogs as potential modulators is to modify an existing modulator in the polypeptide active-site. For example, the computer representation of modulators can be modified within the computer representation of a RPTK ligand binding site. Detailed instructions for this technique can be found in the Molecular Simulations User Manual, 1995 in LUDI. The computer representation ofthe modulator is modified by changing, deleting, or adding one or chemical groups.

Upon each modification to the compound, ligand, or ligand analog, the atoms ofthe modified compound, ligand, or ligand analog and the RPTK can be shifted in conformation, and the distance between the compound, ligand, or ligand analog and the RPTK atoms may be scored along with any complimentary interactions formed between the two molecules. Scoring can be complete when a favorable geometric fit and favorable complementary interactions are attained. Compounds that have favorable scores are potential modulators of RPTK function.

Design bv Modifying the Structure of Compounds that Bind Receptor PTKs

A third method of structure-based modulator design is to screen compounds designed by a modulator building or modulator searching computer program. Examples of these types of programs can be found in the Molecular Simulations Package, Catalyst. Descriptions for using this program are documented in the Molecular Simulations User Guide (1995). Other computer programs used in this application are ISIS/HOST, ISIS/BASE, ISIS/DRAW) from Molecular Designs Limited and UNITY from Tripos Associates.

These programs can be operated on the structure of a compound, ligand, or ligand analog that has been removed from the active-site ofthe three dimensional structure of a compound, ligand, or ligand analog -complexed RPTK complex. Operating the program on such a compound, ligand, or ligand analog is preferable since it is in a biologically active conformation.

A modulator construction computer program is a computer program that may be used to replace computer representations of chemical groups in a compound, ligand, or ligand analog complexed with a RPTK with groups from a computer data base. A modulator searching computer program is a computer program that may be used to search computer representations of compounds from a computer data base that have similar three dimensional structures and similar chemical groups as compounds bound to a receptor PTK. A typical program can operate by using the following general steps: (a) map the compounds, ligands, or ligand analogs by chemical features such as by hydrogen bond donors or acceptors, hydrophobic/lipophilic sites, positively ionizable sites, or negatively ionizable sites;

(b) add geometric constraints to the mapped features; and

(c) search data bases with the model generated in (b). Those skilled in the art recognize that important chemical features include, but are not limited to, a hydrogen bond donor, a hydrogen bond acceptor, and/or two hydrophobic points of contact. Those skilled in the art also recognize that not all ofthe possible chemical features ofthe compound need be present in the model of (b). One can use any subset ofthe model to generate different models for data base searches. IX. Organic Synthetic Techniques

The versatility of computer-based modulator design and identification lies in the diversity of structures screened by the computer programs. The computer programs can search data bases that contain 200,000 molecules and can modify modulators already complexed with a polypeptide, using a wide variety of chemical functional groups. A consequence of this chemical diversity is that a potential modulator of RPTK function may take a chemical form that is not predictable. A wide array of organic synthetic techniques exist in the art to meet the challenge of constructing these potential modulators of RPTK function. Many of these organic synthetic methods are described in detail in standard reference sources utilized by those skilled in the art. One example of such a reference is March, 1994, Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. New York, McGraw Hill. Thus, the techniques required to synthesize a potential modulator of RPTK function identified by computer-based methods are readily available to those skilled in the art of organic chemical synthesis.

X. Cellular Assays Measuring the Effect of a Receptor PTK Modulator in Signal Transduction Pathways Cellular assays can be used to test the activity of a potential modulator of RPTK function as well as diagnose a disease associated with inappropriate RPTK activity. A potential modulator of RPTK function can be tested for activity in vitro by assays that measure the effect of a potential modulator on the autophosphorylation of a particular RPTK over-expressed in a cell line. Thus, a modulator that acts as a potent inhibitor of ligand binding to the extracellular domain corresponding to a RPTK would decrease the amount of autophosphorylation catalyzed by that RPTK. Potential modulators could also be tested for activity in cell growth assays in vitro as well as in animal model assays in vivo.

In vivo assays are also useful for testing the bioactivity of a potential modulator designed by the methods ofthe invention. Materials, methods, and experimental data for these assays are fully described in U.S.

Patent No. 5,792,783, and WO 96/40116 published on December 19, 1996, entitled "Indolinone Compounds for the Treatment of Disease," each of which is incorporated herein by reference in its entirety, including all drawings, figures, and tables.

XI. Administration of Modulators of Receptor PTK Function as Therapeutics for Disease Methods of administering compounds to organisms as therapeutics for disease are fully described in U.S. Patent No. 5,792,783, and WO 96/40116 published on December 19, 1996, entitled "Indolinone Compounds for the Treatment of Disease," each of which is incoφorated herein by reference in its entirety, including all drawings, figures, and tables. XII. Computer-Based Systems for Determining. Designing. Modeling and/or Modifying Molecular Structures

An illustrative computer based system 10 is depicted in Figure 33 for displaying, studying, comparing, manipulating, inteφreting and/or extrapolating data from the crystallographic analysis of molecular structures which include molecules, portion(s) of molecules and/or molecular interactions, such as the molecular structures of RPTKs, their ligands and related complexes depicted in Figs. 1, 2, 5, 19, 26 and 27. Exemplary molecules are proteins and/or complexes of proteins with ligands. Exemplary molecular portions are catalytic domains of proteins, ligand receptor binding sites of proteins, signaling regions of proteins and transport regions of proteins. Exemplary molecular interactions include binding between an enzyme and its substrate, factor/co-factor relationships, antibody/antigen binding, and protein/receptor recognition and binding, such as that occurring in signal transduction. One or more ofthe above types of studies are useful for elucidating and understanding natural biochemical processes and to design and screen mimetics, agonists, inhibitors, and antagonists. Thus, this aspect ofthe invention, among other things, permits the skilled person to understand and practice molecular modeling processes and provides the skilled person with the necessary hardware and software to create and display images that represent the multidimensional structure of a molecule, molecular portion or molecular interaction, as desired. Thus, these undertakings are greatly facilitated by employing computer technology. The system 10 includes data storage entity(ies) 20, such as a memory (e.g, as archival memory and/or video memory and computer-readable medias), that retrievably stores information representing molecule, molecule portions and/or molecular interactions. The memory typically has a first-type storage region or capability 22, having recorded thereon or contained therein structural data, like a set of spatial (atomic) coordinates, specifying a location in a three dimensional space, as disclosed herein or obtained in accordance with the teachings contained herein. The memory also can have a second-type storage region or capability 24, which contains information. This information typically represents a property, characteristic or attribute of one of a plurality of amino acids, or other chemical moiety, for example. A second-type storage region or capability can be associated with the first-type storage regions in the storage entity 20 to represent a geometric and or spatial arrangement of at least one characteristic, property or attribute of a molecule, molecule portion or molecular interaction, preferably one that represents three dimensional space. The memory can take the form of any type recognizable by the skilled person such as RAM and ROM, and other computer-readable mediums like magnetic media, optical media, magnetic-optical media, floppy disks, hard disks, mini-disks, servers, web-based systems, CD, DVD, tape, etc. Memory 22 (a type of storage region or capability) can include or contain, for example, the coordinate data shown in Tables 1, 2, 3, 4 or 6, or other coordinates obtained in accordance with the present teachings, and memory 24 (a type of storage region or capability) can include or contain associated charge or electron density data, for example. Quite commonly, the system includes a plurality ofthe first-type and second-type storage regions. The storage entities 20, namely the first-type storage regions or capabilities 22, said second-type storage regions or capabilities 24, and the storage devices or capabilities 34 can be regions of, for example, a shared semiconductor memory, cache, RAM, ROM, regions of a shared optical disk, regions of a shared magnetic memory, and/or be server based to be accessible by intranet and the internet, including the world wide web. Thus, the systems ofthe present invention include unitary systems, network-based systems, satellite communications, and internet-based systems, which can be interactively connected regardless of geography. The system 10 also includes a processor and/or is interactively associated with a processor, interactively coupled to the data storage entity(ies) to access the first-type storage regions 22 and optionally the second-type storage regions 24, to generate image signals for depicting a visual three dimensional image of at least one characteristic ofthe molecule, molecule portion or molecular interaction in the three dimensional space based on data from the storage entity 20. The processor can be a general or special puφose processor with a CPU, register, memory and the like. Software, and logic architecture and circuitry, can be employed as desired. According to one embodiment, processor 26 and storage entity 20, among other things, can be in the form of a UNIX or VAX computer, such those available from Silicon Graphics, Sun Microsystems, and IBM. However, the invention is not limited to use of these types of hardware and software systems.

A display 28 is commonly interactively coupled to the processor 26 via lines or a wireless connection 30 to receive the image signals in order to depict a visual three dimensional image of at least one characteristic of a molecule, molecule portion or molecular interaction in the three dimensional space based on the data. Suitable displays for use in the system include a computer screen 32 (e.g., CRT, LCD, active and passive matrix, etc.), printer, plotter or film.

In one embodiment ofthe invention, the image data includes data for depicting a visual three dimensional image of a structure of molecule, molecule portion or molecular interaction in three dimensional space, such as shown in Figs. 1, 2, 5, 19, 26 and 27. In another embodiment, the image data includes data for depicting a visual three dimensional image of a solid model representation of molecule, molecule portion or molecular interaction in three dimensional space. In still another embodiment, the image data includes data for depicting a visual three dimensional image of electrostatic surface potential of molecule, molecule portion or molecular interaction in three dimensional space. In yet another embodiment, the image data includes data for depicting a visual three dimensional stereo image of molecule, molecule portion or molecular interaction in three dimensional space.

The system 10 of the present invention may further comprise a storage device, structure, region or capability 34 that stores data representing a geometric and/or spatial arrangement of a characteristic of a composition in addition to the molecule, molecule portion or molecular interaction, such as shown in Figs. 9, 10, 22 and 24. Storage devices or capabilities 34 can include or contain, for example, the three-dimensional X-ray coordinate data for other chemical entities, including other proteins for comparison puφoses. The storage devices and capabilities 34 can take the form of any type recognizable by the skilled person such as RAM and ROM, and other computer-readable mediums like magnetic media, optical media, magnetic-optical media, floppy disks, hard disks, mini-disks, servers, CD, DVD, tape, etc. The processor 26 can be interactively coupled to the storage device or capability 34 and the display 28, and generates additional image data for depicting the geometric arrangement ofthe characteristic ofthe composition relative to said visual three dimensional image of said at least one characteristic ofthe molecule, molecule portion or molecular interaction on the screen 32 based on instructions. In the Fig. 33 embodiment, the storage device or capability 34 is shown as part ofthe storage entity 20, although other arrangements are available to the skilled person. The computer system includes or employs instructions, which can be software or hardware based. The instructions, such as those in logic circuits and software program(s), permit the computer system to, among other things, input, handle, analyze and output data. Exemplary programs are identified herein, although the skilled person is not limited to such programs in the practice ofthe invention.

Typically, the system 10 also includes an operator interface 36, such as a mouse, tracker ball, touch pad, projector (including multi-dimensional projector systems), touch screen, joy stick, pointer, keyboard, modem, card and/or voice recognition system, or docking system for receiving instructions from a operator, which is interactively connected with the display 28, processor 26 and storage entity(ies) 20. Other aspects of computers and computer components are well-known, and are readily obtained.

The computer systems according to the invention, including storage entity 20 (including 22, 24, 34, and others as well) can be programmed and contain data to undertake the analyses discussed in Sections VI-IX above, for example, including the use of x-ray crystallographic data in conjunction with other analytical techniques, such as NMR. The invention also includes computer-readable media containing various data structures and the information disclosed herein. For example, magnetic media, optical media, magnetic-optical media, floppy disks, hard disks, mini-disks, servers, CD, DVD, tape, etc. containing the coordinate data set forth in the accompanying tables and figures, when computer analyzed according to set(s) of instructions and rules provided by hardware and/or software, are useful for ascertaining the three-dimensional structures of molecules, molecular portions and molecular interactions.

EXAMPLES The examples below are non-limiting and are merely representative of various aspects and features ofthe present invention. The examples provide illustrative methods for obtaining crystalline forms of protein kinase polypeptides, methods for determining three dimensional structures of these protein kinase polypeptides, and methods for identifying modulators of protein kinases using the three dimensional structures ofthe protein kinases.

Atomic Structural Coordinates Tables 1-3 provide the atomic structural coordinates for a number of ligand / FGFR complex dimers. Table 5 provides the atomic structural coordinates for a SCF dimer. Table 6 provides the atomic structural coordinates for a the ternary FGF2-FGFR1 -heparin complex. The following abbreviations are used in the Tables:

"Atom Type" refers to the element whose coordinates are provided. The first letter in the column defines the element. "A. A." refers to amino acid.

"X, Y and Z" provide the Cartesian coordinates ofthe element.

"B" is a thermal factor that measures movement ofthe atom around its atomic center.

"OCC" refers to occupancy, and represents the percentage of time the atom type occupies the particular coordinate. OCC values range from 0 to 1, with 1 being 100%. "PRT1" or "PRT2" relate to occupancy, with PRT1 designating the coordinates ofthe atom when in the first conformation and PRT2 designating the coordinates ofthe atom when in the second or alternate conformation.

The structural coordinates for the dimers may be modified by mathematical manipulation. Such manipulations include, but are not limited to, crystallographic permutations ofthe raw structure coordinates, fractionalization ofthe raw structure coordinates, integer additions or subtractions to sets ofthe raw structure coordinates, inversion ofthe raw structure coordinates and any combination ofthe above.

In addition, the structural coordinates can be slightly modified and still render nearly identical three dimensional structures. Therefore, a measure of a unique set of structural coordinates is the root-mean-square deviation ofthe resulting structure. Structural coordinates that render three dimensional structures that deviate from one another by a root- mean-square deviation of less than 1.5 A may be viewed as identical.

Example 1 - X-rav Crystallographic Structure Determination of FGFRl D2-D3 / FGF2 Complexes

Polypeptide Synthesis and Isolation

A DNA fragment encoding residues 142-365 of human FGFRl ("D2-D3") was subcloned into bacterial expression vector pET-23a using Ncol and Hindlll restriction sites using techniques well known to the skilled artisan. Bacterial strain BL21(DE3) was used for expression of D2-D3, and was induced with IPTG for 5 hours. Following induction of expression, the cells were collected by centrifugation, and lysed using a French press in a buffer containing 25 mM potassium phosphate, 150 mM NaCl, 2 mM EDTA, and 10% glycerol.

A pellet containing D2-D3 was collected by centrifugation, and dissolved in 6M guanidium hydrochloride, 100 mM Tris-HCl, pH 8.0. D2-D3 was allowed to refold by dialyzing for 48 hours against a buffer containing 50 mM Tris-HCl, pH 8.0, 150 mM NaCl, 10% glycerol, and 1 mM L-cysteine. The refolded D2-D3 was chromatographed on a heparin sepharose column on which FGF2 had been previously immobilized. The resulting D2-D3 / FGF2 complex was eluted from the heparin sepharose column with a buffer containing 25 mM Tris-HCl, pH 7.5, and 1.5 M NaCl. The D2-D3 / FGF2 complex was concentrated by ultrafiltration using a Centricon

10™ (Amicon) centrifugal concentrator, and further purified by size exclusion chromatography on a Superdex™ 200 column (Pharmacia) using a buffer containing 25 mM Tris-HCl, pH 7.5, and 1.5 M NaCl. Prior to crystallization, the D2-D3 / FGF2 complex was concentrated to 10 mg/mL in a buffer containing 25 mM Tris-HCl, pH 7.5, and 150 mM NaCl.

Crystal Growth

Crystals of purified D2-D3 / FGF2 complex were grown at 20°C by vapor diffusion in hanging drops by mixing equal volumes of protein solution (10 mg/mL D2-D3 / FGF2 complex in 25 mM Tris-HCl, pH 8.5, and 150 mM NaCl) and reservoir buffer (1.6 M (NH₄)₂SO₄, 20% v/v glycerol and 100 mM Tris-HCl, pH 8.5), and suspending a 2.0 μl hanging drop ofthe resulting solution over 0.5 mL reservoir buffer at 20°C.

Data Collection and Structure Determination

Diffraction data were collected from a crystalline specimen, which had been flash frozen in a dry nitrogen stream, at beamline X-4A at the National Synchrotron Light Source, Brookhaven National Laboratory. Synchrotron data were collected on a CCD detector. All data were processed using DENZO and SCALEPACK. Otwinowski, 1993, "Oscillation data reduction program," Proceedings ofthe CCP4 Study Weekend, Sawyer et al., eds. (Daresbury, United Kingdom: SERC Daresbury Laboratory), 56-62.

The structure ofthe D2-D3 / FGF2 complex was determined by molecular replacement using the program AmoRe (Navaza, 1994, Acta Cryst. A 50: 157-163) using the structures of FGF2 (2FGF, Zhang et al, 1991, Proc. Natl. Acad. Sci. 88: 3446-3450) and telokin (1TLK, Holden et al, 1992, J. Mol. Biol 227: 840-851) as search models. Homology models were constructed from the telokin structure for the FGFRl D2 and D3 domains. A molecular replacement solution was determined for both FGF2 molecules and one copy of D2 and D3 in the dimer, and the second copy of D2 and D3 was determined by rigid body rotation and translation ofthe first copy of D2 and D3 onto the second FGF2 molecule. The placement ofthe second copy of D2 and D3 was confirmed by rigid body refinement techniques using CNS (Brϋnger et al, 1998, Acta Cryst. D 54: 905-921).

Simulated annealing and positional B-factor refinement were performed using CNS, and bulk solvent and anisotropic B-factor corrections were applied. Additionally, tight noncrystallographic symmetry constraints were imposed during refinement ofthe backbone atoms of FGF2, D2, and D3. RMS deviation for Cα atoms between the two copies of FGF2, D2, or D3 in the dimer was 0.04 A.

Model building into the electon density maps was performed using the program O (Jones et al, 1991, Acta Cryst. A 47: 110-119). The atomic model ofthe D2-D3 / FGF2 complex includes FGF2 residues 16-144 and FGFRl residues 149-359, except in one ofthe FGFRl receptors in the dimer, where residues 293-307 are disordered. The average B-factor for all atoms is 38.7 A² for all atoms, 37.6/38.9 A² for FGF2, and 38.3/39.1 A² for FGFRl. Atomic Structural Coordinates Table 1 provides the atomic structural coordinates ofthe FGFRl (D2-D3VFGF2 complex dimer complex dimer. The structure ofthe FGFRl (D2-D3)/FGF2 complex has been described in Plotnikov et al., Cell 98, 641-650 (1999) and the coordinates for the FGFRl (D2- D3VFGF2 complex are available on the internet through the Protein Data Bank (assigned Protein Data Bank ID code 1CVS), the disclosures of which are herein incoφorated by reference.

Example 2 - X-ray Crystallographic Structure Determination of FGFRl D2-D3 / FGFl Complexes

Polypeptide Synthesis and Isolation

A DNA fragment encoding residues 142-365 of human FGFRl ("D2-D3") was subcloned into bacterial expression vector pET-23a using Ncol and Hindlll restriction sites using techniques well known to the skilled artisan. Bacterial strain BL21(DE3) was used for expression of D2-D3, and was induced with IPTG for 5 hours. Following induction of expression, the cells were collected by centrifugation, and lysed using a French press in a buffer containing 25 mM potassium phosphate, 150 mM NaCl, 2 mM EDTA, and 10% glycerol.

A pellet containing D2-D3 was collected by centrifugation, and dissolved in 6M guanidium hydrochloride, 100 mM Tris-HCl, pH 8.0. D2-D3 was allowed to refold by dialyzing for 48 hours against a buffer containing 50 mM Tris-HCl, pH 8.0, 150 mM NaCl, 10% glycerol, and 1 mM L-cysteine. The refolded D2-D3 was chromatographed on a heparin sepharose column on which FGFl had been previously immobilized. The resulting D2-D3 / FGFl complex was eluted from the heparin sepharose column with a buffer containing 25 mM Tris-HCl, pH 7.5, and 1.5 M NaCl.

The D2-D3 / FGFl complex was concentrated by ultrafiltration using a Centricon 10™ (Amicon) centrifugal concentrator, and further purified by size exclusion chromatography on a Superdex™ 200 column (Pharmacia) using a buffer containing 25 mM Tris-HCl, pH 7.5, and 1.5 M NaCl. Prior to crystallization, the D2-D3 / FGFl complex was concentrated to 1 mg/mL in a buffer containing 25 mM Tris-HCl, pH 7.5, and 150 mM NaCl. Crystal Growth Crystals of purified D2-D3 / FGFl complex were grown at 20°C by vapor diffusion in hanging drops by mixing one volume of protein solution (1 mg/mL in 25 mM Tris-HCl, pH 8.5, and 150 mM NaCl) with four volumes of reservoir buffer (20% PEG 4000, 0.2 M L.2SO4, and 0.1 M Tris-HCl, pH 8.5), and suspending a 2.0 μl hanging drop ofthe resulting solution over 0.5 mL reservoir buffer at 20°C.

Data Collection and Structure Determination Diffraction data were collected from a crystalline specimen, which had been flash frozen in mother liquor containing 10% glycerol using a dry nitrogen stream, at beamline X- 4 A at the National Synchrotron Light Source, Brookhaven National Laboratory. Synchrotron data were collected on a CCD detector. All data were processed using DENZO and SCALEPACK. Otwinowski, 1993, "Oscillation data reduction program," Proceedings ofthe CCP4 Study Weekend, Sawyer et al., eds. (Daresbury, United Kingdom: SERC Daresbury Laboratory), 56-62. The structure ofthe D2-D3 / FGFl complex was determined by molecular replacement using the program AmoRe (Navaza, 1994, Acta Cryst. A 50: 157-163) using the structures of FGFl (2AFG, Blaber et al, 1996, Biochemistry 35: 2086-2094) and telokin (1TLK, Holden et al, 1992, J. Mol. Biol. 227: 840-851) as search models. Homology models were constructed from the telokin structure for the FGFRl D2 and D3 domains. A molecular replacement solution was determined for two copies each of FGFl, D2, and D3 in the dimer.

Simulated annealing and positional B-factor refinement were performed using CNS, and bulk solvent and anisotropic B-factor corrections were applied. Additionall, tight noncrystallographic symmetry constraints were imposed during refinement ofthe backbone atoms of FGF 1 , D2, and D3. RMS deviation for Cα atoms between the two copies of FGF 1 , D2, or D3 in the dimer was 0.01 A.

Model building into the electon density maps was performed using the program O (Jones et al, 1991, Acta Cryst. A 47: 110-119). The atomic model ofthe D2-D3 / FGFl complex includes FGFl residues 8-138 and FGFRl residues 147-359 except residues 294- 305 and 315-323, which are disordered. The average B-factor for all atoms is 30.4 A² for all atoms, 31.2/33.0 A² for FGFl, and 29.1/28.7 A² for FGFRl.

Atomic Structural Coordinates

Table 2 provides the atomic structural coordinates ofthe FGFRl (D2-D3VFGF1 complex dimer. In the first FGFRl molecule ofthe dimer the residue number is preceded by a 1, e., residue number 464 ofthe first FGFRl molecule ofthe dimer is denoted by "1464". The structure ofthe FGFR1(D2-D3)/FGF1 complex has been described in Plotnikov et al., Cell 101, 413-424 (2000) and the coordinates for the FGFRl (D2-D3VFGF1 complex are available on the internet through the Protein Data Bank (assigned Protein Data Bank ID code 1EVT), the disclosures of which are herein incoφorated by reference.

Example 3 - Determination ofthe FGF2-FGFR2 Structure Crystallization and Data Collection

DNA fragments encoding residues 147 to 366 of FGFR2 were amplified by polymerase chain reaction (PCR) and subcloned into the bacterial expression vector pET-28a using Ncol and Hindlll cloning sites and transfected into the bacterial strain BL21(DE3).

Cells were induced with IPTG for 5 hours, centrifuged and the bacterial pellet was lysed in

25mM K-Na phosphate buffer pH 7.5 containing 150mM NaCl, 2mM EDTA and 10% glycerol using a French press. Following centrifugation, the pellet containing primarily FGFR2 was dissolved in 6M guanidium hydrochloride and lOmM DTT in lOOmM Tris-HCl buffer (pH 8.0). The solubilized FGFR2 protein was refolded by dialysis against 25mM HEPES buffer pH 7.5 containing 150mM NaCl, 10% Glycerol, and ImM L-Cysteine. The refolded FGFR2 protein was loaded onto heparin sepharose columns on which FGF2 (basic FGF) had previously been immobilized. The FGF2-FGFR2 complex was then eluted from the heparin sepharose column with a buffer containing 25mM Tris-HCl (pH 7.5) and 1.5M NaCl. The FGF2-FGFR2 complex was concentrated using Centricon 10 (Amicon) filters and further purified by size exclusion chromatography (Pharmacia, Superdex 200) with a buffer containing 25mM Tris-HCl (pH 7.5) and 1.5M NaCl. The complex migrated at a position consistent with the formation of a 1:1 FGF:FGFR complex.

Crystals were grown by vapor diffusion at 20°C using the hanging drop method. For crystallization ofthe FGF2-FGFR2 complex, 2 microliters of protein solution lOmg/ml, 25mM Tris-HCl (pH 7.5), 150mM NaCl) were mixed with 2 microliters ofthe crystallization buffer containing 10-15% PEG 4000, 10% isopropanol, and 0.1M HEPES-NaOH (pH 7.5). The FGF2-FGFR2 crystals belong to the triclinic space group PI with unit cell dimensions a=72.20 A, b=71.68 A, c=90.92 A, α=90.53°, β=89.98° and γ=89.99°. There are four molecules of FGF2 and four molecules of FGFR2 in the unit cell with a solvent content of ~58%. Diffraction data were collected from flash-frozen (in a dry nitrogen stream using mother liquor containing 10% glycerol as cryo-protectant) crystals on a CCD detector (FGF2- FGFR2) at beamline X4A at the National Synchrotron Light Source, Brookhaven National Laboratory. All data were processed using DENZO and SCALEPACK (Otwinowski et al., Methods Enzymol.276, 307-326 (1997)).

Structure Determination and Refinement ofthe FGF2-FGFR2 structure The structure ofthe FGF2-FGFR2 complex was determined by molecular replacement using the program AmoRe (Navaza, Acta Cryst. A 50, 157-163 (1994)) and the structure of FGF2-FGFR1 (1CVS; Plotnikov et al.,Cell 98, 641-650 (1999)) as the search model. A molecular replacement solution was found for four copies of FGF2-FGFR2 complexes. Model building and refinement were performed with the programs O (Jones et al., Acta Crystallogr. A 47, 110-119 (1991)) and CNS (Brunger et al, Acta. Crystallogr. D 54, 905-921 (1998)), respectively. Tight non-crystallographic symmetry restraints were imposed throughout the refinement for the backbone atoms of FGF2, D2 and D3. The structures ofthe FGF2-FGFR2 complex and the related FGFl -FGFRl complex are reported together with the corresponding X-ray coordinates in Plotnikov et al.Cell 101 : 413-24 (2000), the disclosure of which is herein incoφorated by reference.

The atomic model for FGF2-FGFR2 consists of four FGF2 molecules, four FGFR2 molecules, four sulfate ions, and 263 water molecules. The structure of FGF2-FGFR2 was refined at 2.2 A with an R value of 24.8% (free R value of 27.3%). Data collection and refinement statistics are given in Table 7. The atomic model includes FGF2 residues 16-145 and FGFR2 residues 148-365, 4 sulfate ions, and 263 water molecules. In all four FGFR2 molecules residues 295-306 (bC-bC loop in D3) are disordered. The average B-factor is 40.5 A² for FGF2 molecules, 37.7 A² for FGFR2 molecules, 73 A² for sulfate ions, and 32.6 A² for water molecules.

Atomic Structural Coordinates

Table 3 provides the atomic structural coordinates ofthe FGF2/FGFR2 complex dimer. The structure ofthe FGFR2/FGF2 complex has been described in Plotnikov et al., Cell 101, 413-424 (2000) and the coordinates for the FGFR2/FGF2 complex are available on the internet through the Protein Data Bank (assigned Protein Data Bank ID code 1EV2), the disclosures of which are herein incoφorated by reference.

Table 7 Summary of Crystallographic Analys is

Data Collection Statistics

Structure Resolution (A) Reflections Completeness (%) Rsym (%) Signal «l / σl» (total/unique)

FGF1-FGFR1 25.0 - 2.8 49288 / 22330 97.9 (90.5)^b 8.3 (22.6)^b 8.6

FGF2-FGFR2 25.0 - 2.2 206913 / 93440 96.3 (87.8)^b 4.2 (24.1)^b 16.3

Refinement Statistics⁰

Root-mean- -square Deviations

Structure Resolution (A) Reflections Rcryst / Rfree⁰¹ (%) Bonds (A) Angles (°) B-factors^e (A²)

FGF1-FGFR1 25.0 - 2.8 21539 24.9 / 30.0 0.009 1.5 2.3

FGF2-FGFR2 25.0 - 2.2 84816 24.8 / 27.3 0.007 1.3 1.0

^aR_sym = 100 x ∑_nk|∑i |lj(hkl) - <l(hkl))| / ∑_hk|∑j Ij(hkl).

'Value in parentheses is for the highest resolution shell: 2.90 - 2.80 A (FGF1-FGFR1), 2.28 - 2.20 A (FGF2-FGFR2) c

^CAtomic model: 4963 protein atoms and 4 SO₄ ions (FGF1-FGFR1) and 9818 protein atoms, 4 SO ions, and 263 water molecules (FGF2-FGFR2). d

Rcryst/free = 100 x ∑_nki l|F₀(hkl)| - |F_c(hkl)|| / ∑_n| | |F₀(hkl)|, where F₀ (>0σ) and F_c are the observed and calculated structure factors, respectively. 5% of the reflections were used for calculation of Rfree. ^eFor bonded protein atoms.

Example 4 - SCF Production and Structure Determination

Protein Expression. Refolding and Purification Residue 1 - 141 of human stem cell factor ("SCF") were expressed in E. coli as inclusion bodies as described previously (Langley et al., Arch. Biochem. Biophys. 295, 21-28

(1992)). Inclusion bodies from 1 liter of bacterial culture were dissolved in 25 to 30 ml of

6M guanidine hydrochloride solution. After the solution became clear, DTT was added to a final concentration of 40 mM and incubated at 37°C for 30 minutes. The resulting solution was diluted into 4 liters of buffered solution (10 mM Tris, pH 8.5) and allowed to stand overnight. Refolded protein was purified by ion-exchange chromatography. Protein purity, electrophoretic mobility, and biological activity were compared to SCF that had been prepared with an established procedure (Langley et al., Arch. Biochem. Biophys. 295, 21-28 (1992)) and to a commercially available sample of SCF. Disulfide linked SCF dimers were not detected in this preparation as revealed by non-reducing gel electrophoresis (Langley et al., Arch. Biochem. Biophys. 295, 21-28 (1992)). Crystallization and Data Collection

Crystals of SCF were grown by vapor diffusion at 20°C using the hanging drop method. Two crystal forms are produced. Orthorhombic crystals with unit cell dimensions a = 72.47 A, b = 83.45A and c = 89.15A were grown by mixing 2 microliters of protein sample (15-20 mg/ml) with 2 microliters of reservoir consisting of 25-30% PEG 400, 0.25 M CaCl₂, and 0.1 M HEPES (pH 7.0). The addition of ImM SmCl₃ to the protein solution produced the monoclinic crystals that were used in the structure determination (see Table 4). Monoclinic crystals appeared within hours of set up. Crystals for data collections were flash-frozen in liquid propane directly from the crystallization drops. Initial characterization ofthe SCF crystals was done at synchrotron beamlines X26C and X4A ofthe National Synchrotron Light Source, Brookhaven National Laboratory and the final data collection was done at Argonne National Laboratory Structural Biology Center beamline 19-ID at the Advanced Photon Source. All data were processed using DENZO and the intensities were reduced and scaled using SCALEPACK (Otwinowski et al., Methods Enzymol. 276, 307-326 (1997)).

Structure Determination A molecular replacement attempt with the data collected from the orthorhombic crystals using a model built from the alpha C atom positions ofthe human colony stimulating factor was not successful. Data used for the structure determination were collected from the monoclinic crystals at wavelengths 1.01 A and 1.5 A that are not at the absoφtion edge of Sm. The anomalous signal was clear from Patterson difference maps. The heavy metal position refinement and phasing was done with PHAESE (Furey et al., Methods Enzymol. 277, 590- 620 (1997)). A total of three Sm sites were used for phasing while four Sm atoms were placed in the final model. Only short pieces of helices were visible from the initial solvent flattened electron density map and they were built into the density with program O (Jones et al., Acta Crystallogr. A 47, 110-119 (1991)). Repeated cycles of model building and solvent flattening combined with partial structures were performed until most of all four molecules in the asymmetric unit were built. Subsequent refinements were carried out against the lower energy (wavelength of 1.01 A) diffraction data with Crystallography and NMR System (CNS) (Brunger et al., Acta. Crystallogr. D 54, 905-921 (1998)). Refinement progress was monitored with the R^_e value using a 10% randomly selected test data set, and residue positions adjusted against 2Fo-Fc electron density maps.

The structure was determined by using anomalous scattering differences of samarium ions in the crystal at two wavelengths and refined to 2.3 A (Table 4). There are four molecules in each asymmetric unit and the initial experimental electron density clearly showed the four-helix bundle and two beta strands in the molecules. The connecting loops, as well as the N-terminal and C-terminal regions, were built from 2Fo-Fc maps. Table 4 gives the statistics ofthe final model, which contains 120 solvent molecules, four samarium ions, two calcium ions and one Tris molecule. The structure ofthe human stem cell factor homodimer has been described in Zhang et al., Proc.Nat.Acad.Sci. 97(14), 7732-7737 (2000) and the coordinates for the human SCF dimer are available on the internet through the Protein Data Bank (Protein Data Bank ID code 1EXZ) at http://www.rcsb.org/pdb/cgi/explore.cgi?pid=17825967231743&pdbld=lEXZ, the disclosures of which are herein incorporated by reference.

General Features ofthe Structure

Although there are four SCF protomers in the crystallographic asymmetric unit, the biological dimer is unmistakably recognizable. The four protomers are superimposable except for the N-terminal and C-terminal loop regions. These loops are flexible and adopt multiple conformations in the four molecules in the asymmetric unit. The protomers in the biological dimer are packed head-to-head in a manner of almost perfect C2 symmetry (see Fig. 19). The dimer bends approximately 30° toward the side ofthe beta strands, resulting in an elongated shape with approximate dimensions of 87A x 32A x 25 A.

SCF is a non-covalent homodimer composed of two slightly wedged protomers. The overall topology of a SCF protomer displays an antiparallel four-helix bundle fold (see Fig. 19), in a manner similar to other short-chain helix cytokines (Roswarski et al., Structure 2, 159-173 (1994)). The helices run up-up-down-down, with two crossing beta strands wrapped on one side. The structure ofthe dimer interface shows that dimerization is mediated by extensive polar and non-polar interactions between the two protomers with a large buried surface area. The structure includes a hydrophobic crevice and a charged region at the tail of each protomer that functions as a potential receptor binding site. The X-ray structure of SCF shows that there are extensive interactions between the two SCF protomers, with approximately 1700 A² surface area buried upon dimerization (calculated with a probe of radius 1.4 A). This buried surface area accounts for about 20% ofthe total surface of each individual protomer, and is twice that reported for the 850 A² buried surface area ofthe disulfide linked M-CSF dimer.

The side chains ofthe hydrophobic residues ofthe four helices pack the core of each monomer. Cys4 and Cys89 as well as Cys43 and Cysl38 form two intramolecular disulfide pairs. Both disulfide bonds are located at one end (tail) of each protomer away from the dimer interface. The Cys4-Cys89 disulfide bond is more exposed than Cys43-Cysl38, a disulfide bond wrapped by the side chains of Val39, Leu98, Pro40 and His42. This probably explains why the Cys4-Cys89 bond is more susceptible to chemical reduction than the Cys43-Cysl38 disulfide bond (Lu et al, J. Biol. Chem. 271, 11309-1131 (1996)).

The SCF dimer interface is composed of loops between alphaA and betal, alphaB and alphaC, and can also be divided into three layers (see Fig. 21). The bottom layer at the side of the beta strands is composed of hydrophobic interactions. Side chains from Tyr26, Pro23, Phe63 and Leu22 from one protomer pack against corresponding side chains from the other protomer, with Tyr26-Asp25' and Tyr26'-Asp25 forming a hydrogen bond circle as the caφet (see Fig. 2B). These intermolecular hydrogen bond pair replace the intermolecular disulfide bond between the two M-CSF protomers (Bazan, Cell 65, 9-10 (1991); Broudy, Blood 90, 1345-1364 (1997)). Sequence alignment shows that this Tyr-Asp pair is preserved ϊnflt3 ligand, the third member of this family of cytokines that also forms dimers by non-covalent interactions (Hannum et al., Nature 368, 643-648 (1994)). At the core ofthe interface, the side chains of four asparagine residues (Asn72 and Asn21 from both protomers) form hydrogen bonds among themselves as well as via a water molecule (see Fig. 21). This well coordinated water molecule forms hydrogen bonds with an average bond length of 2.7A with the two carbonyl oxygen atoms ofthe two symmetry related Asn21 residues. The top layer involves interactions between loop alphaB-alphaC of one protomer against that ofthe other protomer. In addition to a dozen hydrogen bonds formed between the two protomers, there are four possible salt bridges between Lysl7-Glu68\ Lys24-Asp61\ and their symmetry related counteφarts.

Example 5 - Structure Determination Ternary FGF2-FGFR1 -Heparin complex The expression, purification and crystallization of FGF2-FGFR1 complexes were carried out as described previously (Plotnikov et al., Cell 98, 641-650 (1999)). Crystals ofthe native FGF2-FGFR1 complex were incubated in 10 μl of stabilizing solution (40 % PEG 8000,

0.25M ammonium sulfate, 0.1M Tris-HCl (pH 8.5)) containing ImM decasaccharide for one week at 20 °C. Data were collected on a flash-frozen crystal (in a dry nitrogen stream using mother liquor containing 10 % glycerol as cryo-protectant) on a CCD detector at beamline X4A at the National Synchrotron Light Source, Brookhaven National Laboratory. Data were processed using DENZO and SCALEPACK (Otwinowski, "Oscillation data reduction program," in Proceedings ofthe CCP4 Study Weekend. Sawyer et al., (eds). (SERC Daresbury Laboratory, Daresbury, United Kingdom) (1993) ). Difference Fourier electron density maps were computated using the FGF2-FGFR1 structure (Plotnikov et al., 1999). Initial model for the oligosaccharide was taken from the crystal structure of FGF2 in complex with hexasaccharide (IBFC) (Faham et al., Science 271, 1116-1120 (1996)). The parameters for the oligosaccharide were generated using the HIC-Up server (Kleywegt et al., Acta Crystallogr. D54, 1119-1131 (1998)). Simulated annealing and positional/B-factor refinement were performed using CNS (Bruenger et al., Acta. Crystallogr. D 54, 905-921 (1998)). Model building into 2F₀-F_C and F₀-F_c electron density maps was performed with the program O (Jones et al., Acta Crystallogr. A 47, 110-119 (1991)). The average B-factor is

36.9 A² for all atoms, 35.0 A² for FGF2, 35.3 A² for FGFRl, and 72.4 A² for decasaccharide molecules. Structure Determination

Since a heparin binding canyon is present in the FGF2-FGFR1 crystals, incubation of these crystals with decasaccharide facilitated obtaining a ternary FGF-FGFR-heparin complex. The crystal structure ofthe ternary FGF2-FGFR1 -heparin complex was solved using the phases obtained from the FGF2-FGFR1 structure. Data collection and refinement statistics are given in Table 5. It was anticipated to find a single decasaccharide molecule (heparin) traversing the canyon and bridging the ligands. However, the difference Fourier electron density map clearly shows two decasaccharide molecules in the canyon (see Figs. 27 and 28). Only the first 6 sugar rings (A to F) are observed to interact with protein. Consequently, the electron density is well defined for these rings. In addition, due to favorable lattice contacts, two additional sugars (rings G and H) could be modeled for one of the decasaccharides.

Atomic Structural Coordinates

Table 6 provides the atomic structural coordinates ofthe the ternary FGF2-FGFR1- heparin complex.

Heparin Structure

The heparin can be approximated as a helix generated by repeating disaccharide units of D-glucosamine (GlcN) and L-iduronic acid (IdoA) joined by α-1-4 linkages. Each disaccharide unit is sulfated at three positions; one at the 2-hydroxyl group of IdoA and two at the 2-amino and 6-hydroxyl groups of GlcN. Sulfate and carboxylate groups form the negatively-charged edges ofthe heparin helix and appear on a given side ofthe helix every 17-19 A on average. These helical parameters are in agreement with the X-ray fiber diffraction values of 8.7 A and 180° for a heparin polymer (Nieduszynski et al., Am. Chem. Soc. Symp. Ser. 48, 73 (1977)). Heparin polysaccharides are polar entities with a non- reducing end (04) and a reducing end (01). In the crystal structure, the decasaccharides bind with their non-reducing ends in the center of canyon and run out onto the high-affinity heparin binding sites ofthe ligands. Consequently, the symmetry ofthe dimeric assembly is maintained. Traversing ofthe canyon by one polar heparin molecule disrupts the two-fold symmetry ofthe system. Several intramolecular hydrogen bonds stabilize the helical conformation ofthe decasaccharide (data not shown). The GlcN rings are all found in a chair conformation. The IdoA rings are in either a chair or a skewed boat conformation as previously observed in the solution structure of a dodecasaccharide (Mulloy et al., Biochem. J. 293, 849-858 (1993)), suggesting that IdoA can adopt multiple conformations depending on the contacts it makes with FGF or FGFR. It is likely that the conformational flexibility of IdoA plays a role in specific recognition of various FGFs or FGFRs. Heparin-FGF and Heparin-FGFR Interactions

Each decasaccharide makes a total of 30 hydrogen bonds with FGF and both FGFRs (see Figs. 29 and 30). Within one 1:1 FGF:FGFR complex, 25 hydrogen bonds are made with heparin. The remaining 5 hydrogen bonds with heparin originate from the FGFR ofthe adjoining 1:1 FGF :FGFR complex. Lysines 160, 163, 172, 175 and 177, located on the heparin-binding surface of D2, form 7 hydrogen bonds between FGFR and heparin in the context of a 1:1 FGF:FGFR complex. With the exception of a single hydrogen bond between Lys- 175 and heparin, which is mediated by a ring oxygen of heparin (ring A), the remainder of these hydrogen bonds are sulfate-mediated. All three types of heparin sulfate groups (N- sulfate, 2-O-sulfate and 6-O-sulfate) are employed in these interactions (Figs. 29 and 30). At the FGF-heparin interface, a total of 18 hydrogen bonds are made, of which half are sulfate-mediated (Figs. 29 and 30). The other half is mediated by carboxylate, linker or ring oxygens of heparin. Surface residues Asn-27 (located in the βl-β2 loop), Arg-120, and Thr-121 (located in the β9-βl0 loop), Lys-125, Lys-129, Gln-134, Lys-135, and Ala-136 (located in βl l-βl2 loop) form the heparin-binding site on FGF. These residues are the same ones that interact with heparin in the FGF2-hexasaccharide structure (Faham et al., Science 271, 1116-1120 (1996)). However, since the orientation ofthe heparin helix with respect to FGF is flipped between these two structures, the hydrogen binding pairs are not identical.

Aside from a single hydrogen bond between Lys-135 of FGF2 and a 6-O-sulfate (ring B) of heparin, the remainder ofthe sulfate-mediated interactions involve N-sulfate and 2-O- sulfate groups. This provides an explanation for why FGF2 has been reported to retain binding ability to 6-O-desulfated heparin. Nevertheless, 6-O-desulfated heparin oligosaccharides are still ineffective in promoting FGF2-FGFR interaction. In the present crystal structure, the 6-O-sulfate of ring B (Figs. 29 and 30) makes hydrogen bonds with heparin-binding residues of both FGF and FGFR. Concurrent binding of both FGF and FGFR to the same sulfate group of heparin clearly serves to increase the apparent affinity of FGF for FGFR. Hence, the present structure also provides a molecular basis for the well- documented heparin-dependent 1:1 FGF:FGFR interaction. In addition to promoting FGF-FGFR interaction within the 1 : 1 FGF:FGFR complex, heparin also interacts with the adjoining receptor across the two-fold dimer. A total of 5 hydrogen bonds are made at this interface between FGFR residues Lys-207 and Arg-209 and sugar rings A-D of heparin (Figs. 29 and 30). Hydrophobic contacts between Ile-216 and the non-reduced ring A of heparin further fortify this interface. The hydrogen bonds between Lys-207 and heparin are mediated via carboxylate, linker and ring oxygens of heparin. In contrast, Arg-209 makes hydrogen bonds with the 6-O-sulfate group of ring D, thereby emphasizing the critical dual role of 6-O-sulfate in promoting 1:1 FGF2:FGFR interaction and inducing 2:2 FGF:FGFR dimer formation. The crystal structure provides a plausible explanation for the well-documented inability of 6-O-desulfated heparin oligosaccharides to promote mitogenic activities by failing to induce receptor dimerization.

Table 5. Summary of Crystallography : Analysis

Data Collection Statistics

Resolution (A) Reflections Completeness Rsym^a (%) Signal «l / (total/unique) (%) σl»

30.0 - 3.0 97669 / 19774 97.2 (92.6)^b 7.0 (30.3) 12.3

Refinement Statistics⁰

Root-mean-square Deviations

Resolution (A) Reflections Rcryst I Rfree^d Bonds (A) Angles (°) B-

(%) factors^e (A*)

25.0-3.0 18305 23.1 / 28.9 0.011 1.6 1.28

^aR_Sym = 100 x ∑_hk|∑j |lj(hkl) - <l(hkl))| / ∑_hk|∑, Ij(hkl). alue in parentheses is for the highest resolution shell: 3.11.-3.00 A. Atomic model: 5245 protein atoms and 245 decasaccharide atoms.

Rcryst/free = 00 x ∑_hk| ||F₀(hkl)| - |F_c(hkl)|| / ∑_hk, |F₀(hkl)|, where F₀ (>2σ) and F_c are the observed and calculated structure factors, respectively. 5% of the reflections were used for calculation of Rfree. ^eFor bonded atoms. The invention illustratively described herein may be practiced in the absence of any element or elements, limitation or limitations which is not specifically disclosed herein. The terms and expressions which have been employed are used as terms of description and not of limitation, and there is no intention that in the use of such terms and expressions of excluding any equivalents ofthe features shown and described or portions thereof, but it is recognized that various modifications are possible within the scope ofthe invention claimed. Thus, it should be understood that although the present invention has been specifically disclosed by preferred embodiments and optional features, modification and variation ofthe concepts herein disclosed may be resorted to by those skilled in the art, and that such modifications and variations are considered to be within the scope of this invention as defined by the appended claims.

The contents ofthe articles, patents, and patent applications, and all other documents and electronically available information mentioned or cited herein, are hereby incoφorated by reference in their entirety to the same extent as if each individual publication was specifically and individually indicated to be incoφorated by reference. Applicants reserve the right to physically incoφorate into this application any and all materials and information from any such articles, patents, patent applications, or other documents.

The terms and expressions employed herein have been used as terms of description and not of limitation, and there is no intention in the use of such terms and expressions of excluding any equivalents ofthe features shown and described or portions thereof, but it is recognized that various modifications are possible within the scope ofthe invention claimed. Thus, it should be understood that although the present invention has been specifically disclosed by preferred embodiments and optional features, modification and variation ofthe inventions embodied therein herein disclosed may be resorted to by those skilled in the art, and that such modifications and variations are considered to be within the scope of this invention.

The structure ofthe FGFRl (D2-D3)/FGF2 complex has been described in Plotnikov et al., Cell 98, 641-650 (1999). The structures ofthe FGFRl (D2-D3)/FGF1 complex and the FGFR2/FGF2 complex are described in Plotnikov et al., Cell 101, 413-424 (2000). The structure ofthe human stem cell factor homodimer is described in Zhang et al., Proc.Nat.Acad.Sci. 97(14), 7732-7737 (2000). The disclosures of these three references are herein incoφorated by reference.

The following bibliography includes general references relating to RPTKs as well as citations relating more specifically to the structure ofthe FGF-FGFR-heparin ternary complexes described herein.

Basilico, C, and Moscatelli, D. (1992). The FGF family of growth factors and oncogenes.

Adv. Cancer Res. 59, 115-165.

Bruenger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R.

W., Jiang, J. S., Kuszewski, J., Nigles, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998). Crystallography and NMR system: A new software suite for macromolecular structure determination. Acta. Crystallogr. D 54, 905-921.

Burgess, W. H., and Maciag, T. (1989). The heparin-binding (fibroblast) growth factor family of proteins. Annu. Rev. Biochem. 58, 575-606.

Esnouf, R. M. (1997). An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. J. Mol. Graph. Model 15, 132-134.

Faham, S., Hileman, R. E., Fromm, J. R., Linhardt, R. J., and Rees, D. C. (1996). Heparin structure and interactions with basic fibroblast growth factor. Science 271, 1116-1120.

Faham, S., Linhardt, R. J., and Rees, D. C. (1998). Diversity does make a difference: fibroblast growth factor-heparin interactions. Curr. Opin. Struct. Biol. 8, 578-586. Gambarini, A. G., Miyamoto, C. A., Lima, G. A., Nader, H. B., and Dietrich, C. P. (1993).

Mitogenic activity of acidic fibroblast growth factor is enhanced by highly sulfated oligosaccharides derived from heparin and heparan sulfate. Mol. Cell Biochem. 124, 121-

129.

Galzie, Z., Kinsella, A. R., and Smith, J. A. (1997). Fibroblast growth factors and their receptors. Biochem. Cell. Biol. 75, 669-685.

Guimond, S., Maccarana, M., Olwin, B. B., Lindahl, U., and Rapraeger, A. C. (1993).

Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for

FGF-1, FGF-2 and FGF-4. J. Biol. Chem. 268, 23906-23914.

Ishihara, M. (1994). Structural requirements in heparin for binding and activation of FGF-1 and FGF-4 are different from that for FGF-2. Glycobiology 4, 817-824.

Jaye, M., (1992). Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction. Biochim. Biophys. Acta 1135, 185-199. Johnson, D. E., and Williams, L. T. (1993). Structural and functional diversity in the FGF receptor multigene family. Adv. Cancer Res. 60, 1-41.

Jones, T. A. (1991). Improved methods for binding protein models in electron density maps and the location of errors in these models. Acta Crystallogr,. A 47, 110-119. Kley wegt, ( 1998). Databases in protein crystallography. Acta Crystallogr. D54, 1119-1131.

Kraulis, P. J. (1991). MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr. 24, 946-950.

Merrit, E. A. and Bacon, D. J. (1997). Raster3D: photorealistic molecular graphics. Meth.

Enzymol. 277, 505-524. Mulloy, B, Forster, M. J., Jones, C, and Davies, D. B. (1993). N.M.R. and molecular- modelling studies ofthe solution conformation of heparin. Biochem. J. 293, 849-858.

Naski, M. C. (1998). FGF signaling in skeletal development. Front Biosci. 3, D781-794.

Nicholls, A., Shaφ, K. A., and Honig, B. (1991). Protein folding and association: insights from interfacial and thermodynamic properties of hydrocarbons. Proteins 11, 281-296. Nieduszynski, (1977). Am. Chem. Soc. Symp. Ser. 48, 73.

Nishimura, T., Nakatake, Y., Konishi, M., and Itoh, N. (2000). Identification of a novel FGF,

FGF-21, preferentially expressed in the liver. Biochim. Biophys. Acta, 1492, 203-206.

Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Courier, F., Gao, G., and Goldfarb, M. (1996). Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271, 15292-15297.

Ornitz, D. M., Yayon, A., Flanagan, J. G., Svahn, C. M., Levi, E., and Leder, P. (1992).

Heparin is required for cell-free binding of bFGF to a soluble receptor and for mitogenesis in whole cells. Mol. Cell. Biol. 12, 240-247.

Ornitz, D. M., Herr, A. B., Nilsson, M., Westman, J., Svahn, C. M., and Waksman, G. (1995). FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides. Science 268, 432-436

Otwinowski, Z. (1993). Oscillation data reduction program. In Proceedings of the CCP4

Study Weekend. (SERC Daresbury Laboratory, Daresbury, United Kingdom).

Plotnikov, A. N., Schlessinger, J., Hubbard, S. R., and Mohammadi, M. (1999). Structural basis for FGF receptor dimerization and activation. Cell 98, 641-650.

Plotnikov, A. N., Hubbard, S. R., Schlessinger, J., and Mohammadi, M. (2000). Structural basis for FGF receptor dimerization and activation. Cell 101, 413-424. Pye, D. A., Vives, R. R., Turnbull, J. E., Hyde, P., and Gallagher, J. T. (1998). Heparan sulfate oligosaccharides require 6-O-sulfation for promotion of basic fibroblast growth factor mitogenic activity. J. Biol. Chem. 273, 22936-22942.

Rapraeger, A. C, Krufka, A., and Olwin, B. B. (1991). Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation. Science 252, 1708- 1708.

Rusnati, M., Coltrini, D., Caccia, P., Dell'Era, P., Zoppetti, G., Oreste, P., Valsasina, B., and

Presta, M. (1994). Distinct role of 2-O-, N-, and 6-O-sulfate groups of heparin in the formation of the ternary complex with basic fibroblast growth factor and soluble FGF receptor-1. Biochem. Biophys. Res. Commun. 203, 450-458. Stauber, et al. (2000).. Proc. Natl. Acad. Sci. USA 97, 49-54.

Venkataraman, G (1999). Proc. Natl. Acad. Sci. USA 96, 3658-3663.

Yayon,. (1991). Cell 64, 841-848.

Spivak-Kroizman. (1994). Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation. Cell 79, 1015-1024. Zhou, F. Y. et al.. Eur. J. Cell Biol. 73, 71-80.

Cross Reference to Related Applications This application claims priority under 35 U.S.C. §119(e) of U.S. Provisional

Application Serial No. 60/151,810, filed August 30, 1999, the disclosure of which is herein incoφorated by reference in its entirety.

Table*

Table 1 FGFRl D2-D3 Complexed with FGF2

ATOM 1 CB HIS A 16 69. 016 29. 963 137. 171 1. 00 41. 99

ATOM 2 CG HIS A 16 67. 950 29. 424 138. 074 1. 00 44. 70

ATOM 3 CD2 HIS A 16 67. 435 29. 899 139. 233 1. 00 44. 60

ATOM 4 ND1 HIS A 16 67. 286 28. 242 137. 817 1. 00 45. 58

ATOM 5 CE1 HIS A 16 66. 412 28. 011 138. 781 1. 00 45. 34

ATOM 6 NE2 HIS A 16 66. 481 29. 002 139. 652 1. 00 45. 97

ATOM 7 C HIS A 16 68. 950 28. 141 135. 513 1. 00 42. 15

ATOM 8 O HIS A 16 68. 419 28. 749 134. 583 1. 00 44. 62

ATOM 9 N HIS A 16 71. 039 29. 455 135. 830 1. 00 40. 32

ATOM 10 CA HIS A 16 69. 840 28. 875 136. 502 1. 00 41. 81

ATOM 11 N PHE A 17 68. 761 26. 844 135. 742 1. 00 41. ,35

ATOM 12 CA PHE A 17 67. ,965 25. 985 134. 864 1. ,00 40. ,26

ATOM 13 CB PHE A 17 68. ,024 24. ,543 135. ,383 1. ,00 37. ,06

ATOM 14 CG PHE A 17 67. ,253 24. ,321 136. ,661 1. ,00 36. ,58

ATOM 15 CDl PHE A 17 65. ,951 23. ,823 136. ,632 1. ,00 35. ,88

ATOM 16 CD2 PHE A 17 67. .796 24. .674 137. .891 1. .00 35. .10

ATOM 17 CE1 PHE A 17 65. 210 23. 686 137. .809 1. ,00 32. .72

ATOM 18 CE2 PHE A 17 67. ,052 24. ,539 139. ,064 1. .00 31. .85

ATOM 19 CZ PHE A 17 65. ,761 24. ,047 139. ,018 1. .00 30. .46

ATOM 20 C PHE A 17 66. ,510 26. ,413 134. .643 1. .00 41. .70

ATOM 21 O PHE A 17 65. ,914 26. .068 133. ,623 1. .00 42. .96

ATOM 22 N LYS A 18 65. ,942 27. .163 135. ,587 1. .00 42. .87

ATOM 23 CA LYS A 18 64. .556 27. .622 135. .488 1. .00 42. .89

ATOM 24 CB LYS A 18 64. .083 28. .161 136. .843 1. .00 40, .05

ATOM 25 C LYS A 18 64. ,348 28. .702 134. ,420 1. .00 43. .25

ATOM 26 O LYS A 18 63. .273 28. .783 133. .818 1. .00 43. .36

ATOM 27 N ASP A 19 65. .377 29. .522 134. .190 1. .00 42, .81

ATOM 28 CA ASP A 19 65. .312 30. .618 133. .216 1. .00 40, .93

ATOM 29 CB ASP A 19 66. .335 31. .686 133. .579 1, .00 41. .73

ATOM 30 CG ASP A 19 66. .025 32. .348 134, .896 1 .00 43 .73

ATOM 31 OD1 ASP A 19 65, .882 31, .624 135, .903 1 .00 46 .50

ATOM 32 OD2 ASP A 19 65, .919 33, .591 134 .931 1 .00 43 .92

ATOM 33 C ASP A 19 65, .520 30, .193 131 .765 1 .00 38 .86

ATOM 34 O ASP A 19 66. .038 29, .108 131, .492 1 .00 38, .38

ATOM 35 N PRO A 20 65. .097 31, .044 130, .809 1 .00 36 .59

ATOM 36 CD PRO A 20 64, .245 32, .233 130, .938 1 .00 36 .39

ATOM 37 CA PRO A 20 65, .263 30 .712 129 .396 1 .00 34 .39

ATOM 38 CB PRO A 20 64, .474 31 .799 128, .673 1 .00 31 .04

ATOM 39 CG PRO A 20 63, .467 32 .189 129, .638 1 .00 33 .58

ATOM 40 C PRO A 20 66 .726 30 .773 129 .038 1 .00 34 .58

ATOM 41 O PRO A 20 67 .507 31 .506 129 .657 1 .00 35 .62

ATOM 42 N LYS A 21 67. .089 30 .000 128, .027 1 .00 32 .92

ATOM 43 CA LYS A 21 68, .449 29 .959 127 .556 1 .00 32 .11

ATOM 44 CB LYS A 21 69 .042 28 .572 127 .773 1 .00 31 .65

ATOM 45 CG LYS A 21 69 .408 28 .268 129 .214 1 .00 33 .27

ATOM 46 CD LYS A 21 70 .054 26 .901 129 .323 1 .00 32 .63

ATOM 47 CE LYS A 21 70 .056 26 .396 130 .757 1 .00 34 .58

ATOM 48 NZ LYS A 21 70 .472 24 .961 130 .814 1 .00 35 .96

ATOM 49 C LYS A 21 68 .481 30 .296 126 .078 1 .00 32 .97

ATOM 50 0 LYS A 21 67 .484 30 .154 125 .377 1 .00 32 .04

ATOM 51 N ARG A 22 69 .626 30 .779 125 .613 1 .00 33 .48

ATOM 52 CA ARG A 22 69 .784 31 .097 124 .209 1 .00 32 .66

ATOM 53 CB ARG A 22 70 .360 32 .501 124 .032 1 .00 32 .91

ATOM 54 CG ARG A 22 69 .297 33 .575 123 .837 1 .00 34 .86 in cj i-- ^ (Ji H M (ji (o n in H H W '^ t^ n i g in o o f r M M r M ro co r oo r p oo ro r co 'O oo c ooooooooooooooooooo ooooooooooooooooooo

oo 'j3 θ H fθ Lr) θ r-- ιJ3 σi rH ^i' ι-H M co r~ 3 r n o m unD N c w H CD n r- N n ^ 'j H W r-- oo r- o m Lr⁾ 'a^, r i-H o o CM CN C CM C CO "sf i-H rH o o o ffi αj oo o fli o ifl MB r- n co H H O N ci ixi O M v o m H in 'j Mn M σι tyι ιn <ϊ in <ι^, r'i r^f) N ω m m N N M^ι ω ro « r- w ifl i ιn ιn Λ r- oo o H N θ ιn o » ffl σι o σi oo o o H θ H o σι m o c>) H i») <» ιn ιo ^ (o » Mij o ^ m f i <i' Λ io ^ cri cri rH n ^ n o oo oo oo oo cΛ r^ oo r- oo oo oo r- r-

10 r- '-o " > r- Γ— oo i— i— r- r- c^ r~ [-- r- r-~ p- r~ i^ r~

^__ - -- -- -- - -- -- - - - - - I-I I-H^' ,-i _{> h} ι₁-i μι rt; <;<; ; rt;rt; κi; o u u u o

Q ω co ac x s to CO o Q ω N <fflUQQ o z u z z o o z j uo u υo o z υ u o o cj u υ u o υ z o υ w u o z o u υ u u z u o z ϋUUOZ u o z u α O S3

_o vo r~ ∞ <^ θ ιH M ^ iJ o r~ OT cn o H C ro ^ ιn i r~ ∞ cΛ θ H r ^ ^ in ln ln ^ u^ ω ω ^o W ^o ^o ^o ^o ^l-⁾ ^ t^,• ^ ι~^• r~^■ r-^• r- ^ αl oo co ω eo ω ct) ω ω c ^Λ σ^ σl σl σl σl σι σl σι m o o o o o o o o o o

o

N W o ω in n o σi N H in ω ω o o pi i O 'i' ii i H N iB o w ιn o vι ιo r~ ιτ o ^ ^ M H σi H in w θ ! io « H σι r- ι-- n '* ^ n H o o o r^ r M θ Ln ^ oo M M in M ^ c^ r^ ιn ι-H Ni υ3 'τ r 'q^, oo cM r ^θ H ^r o crι

«5 oo oo co oo co ro oo oo oo ro oo oo r n n oo co oo r co oo r r oo ro ro oo ro oo ro m oo cvi ro cM cNi cM iH υ H ooooooooooo ooooooooooooooooooooooooooooooooooo ooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooo

VO vθ Ln oo ι-H M M θ r n n vo

H H rr-- MM cCoo ooo MM mO rr~-- oσoϊ eσni u> r- oo w r- ω oo O 00 CM O ιr) ιj3 i-3 r- r- r- en UP Γ~ -n OO ln σι n ^ ln N ^D N oa H W (D o ω ^ ^O {n on o n ^D ιn <» H ^l 'J' o^ o <l^, N H σl oo ^ o ^ c>^ m v ι^τ) ^n o ffl o o <I ω ^ ^ ^ ^ d N •ιf ^ O ^ H l (η a H rη H >J ^ o ^ ιη oo ^ co ^ o w o co co ^ 9 '^• ^ι ^ H H n tD oo ^n (J n o ^D ι^ H oo o^ ^ι ιη ul o ι tD Λ ^ (η o o ^fl H H N ^ ^ t^ n vf ιn o ln m ^ π ^D (ι ω u^ l H ^ ^O H ιn co ιn ^|^l o ^o ^ c^ι tD ^ σι o3 rl to o3 ^^ ln o ^ n ^ cn ^O ln ^ co ln o o o

H N i H rl O H O CM H n N O Ol H H N CM ^ n in ^ O H Ol CO lO lfl l IJl O ai O H N ^ PI ^ te ^ O Ol O IIl C eO ^ lO O H H M M oo oo oo oo ro oo oo oo oo rη r co oo cNj oo oo oo oo oo oo oo r oo ro oo cM CM CM ( CM CM CM r ( j oo oo ro n oo oo rn oo

HOOomσl

(J1 \0100000000000HHHHHHHHHHH(\|«NNNN(<)( I^,)l^,)n( f rθrθ( nfO( _'»*'irM^,'<l"»>»Vininin c^ CM CM Co cn ro r M oo n oo n ro oo oo oo oo n ro oo n oo ro oo oo ro n oo oo oo oo o oo ro n r o oo oo ro ro cn r ro oo rii < rt; < ( < rf; ^ ι< ι rt: ι fiC (a: (< rt; rt; ι< ^ < <; f< < rt f< f^ h k4 j κ x aα κ κ w κ a κ κ a κ -c κ ffi 3, ac ac a3 ac x a ω w ω ω ω ω w ω ii oJai i- iϊiaj s iϊi Λ βi oS ij j j j J tjHi j H HH l5 tJ O (- (ll Λ Qι αι Ilι fc αι llι a( Ol ll. aι Clj (lι |l< (lι (lι (-l Il| (lι Bι J ι-) ^ ^ ιJ ι-l j j ι< fi; ; «ι; ((; ι< «ι; H H H H H H H H K ϊ a rH CM rH CM CM rH

< CO U Q u zυυυυuυυυooz PP υ u υ U O O O z υ u υ D c u w N a z u z azc u o z u CO O O Q

U U o υ C o z rtυ! CoO

O H <^ι n ^ ιn w ^ α) σι o H (^ι n ^ ιJ1 lB ^ m Λ O H ι n ^ ln ^ ^ 3 <Jl O H !N n ^ ιn w ^ co <^ι o H l (») '» ln ^D ^ ι ) m o H l (<l ^

00 H H H H H ri rl H H H H ri H H H H H H H H H H ri rl H H H H ri H H H ri H H ri H ri H H ri ri ri ri H H ri H H ri H H H H H rH

o ooooooooooooo2o2oSoo22oo2o22o2ooS2o2oo22oo22o2o2oo22o2o2oo2o22oo22oo22o2o2o2o2o2oo2o2o22o2oo22o2o

Tf

JS

<aⁱ ^^ι o "=r o r~ o CM en σi rH o u ^ι' u < ) uo cn o ι-H θ r~ r- iΛ σi 'q> ⁽-n ii> o «3< o oo o cM '3^, o o oo '<j^{, ,}o M o r~ o r- c^ m o M ¹Λ i- iJ '3' p-

© o ^■di s oo r- o <JD rH rH O VO f- rH ^o u oo r- o oo in uo oo uo m r w m 'q' CM CM rH θ *-3 ^|.o o o oo r~ c '!3^, r u3 oo r- H r- oo rH rH cn υD r~- M

N m ( η n ( cg ( W f ^ι n ^ ^ ^ ^ ln ol ^ H ln ln ^ ^l N H N ^ ιn ^ ^ ^ ra lrι ln ^ lΛ n ^ H O 'τ n ^ n M ^ v « f f>) (J ( ^^ ro ro co cη oo ro r r ro r oo oo ro r o r cη oo ro ^ r ro ro r m oo oo oo oo ro oo oo oo oo r ro ro fη oo cn r^

H υ ooooooooooooooooσooooooooooooooooooooooooσoσooooooooooo a. ooooooooooooooooooooooooooooooooooooooooooooooooooooooo

(^ <_f O (Jl m r- O H m H (ι r■ ln o o ol ^ ^ ^ ιJl l H oo ul J O H ^ ^ 9 H (Λ m ^ ^I> ^ (N O ^ ^ o H ^I) ^ H O H ^^ι ^ ( ^ ^ H ^o ^ (n σl ^ H ιc o (Il H ^ ιn o oo M O ri ^ ^ o n o m H ^ι o c^l Ol O co N ^ι ιrι ^^ H ln H Ol ^(l (I) <Λ oo H c^ι ιn ιn ι ) H ln ^β ϊι (l f ^|fi ^ ^ ^ ω w ^O ln Φ O ιn m la r~ o ^ o ^ l^, m ^ ln ω o ^ ^ (η ^ H ^n H r^ ^o ^ (^ι ω H oo f^ ( ^ ιΛ fl^| W ^^ ^ o300 r^ O r^ ^ (η H ^ N

N H (η o^ l ri O N ^ (ι ^ ^ H H H H l^ H O H l o^ m ^ ^ ^J) ι co σl m o H (ι n M co (I) ^ ^ ιn lrι l r■ ^^■ (I) co tΛ ri cl H (Il σι o o ^l m M r rO OO OO OO OO OO OO rO cn oO OO OO OO OO OO OO OO CM CM CM CM CM CNl Cvl CM CM CM CO OO CO r^

CO o ^ u1 H n H co ll lI ol lJl a) o m ^ O H Ol ^ ^ H O ^ H ln o o ^£H£l ffl ^!⁾ o m m ^o o (Jl Ol f ω o ^o cΛ l rl ^ ^fl ^f 03 (ι o 'ϊ r• o t\ n ^ ln ^ o^ ∞ O l N (η ω ^O (Jl ^ H tη H » ro t^ι ^ N ^ (η m ^ (X3 ^ ^ H J O O m co ^• H ^ι co ^O H ( M ^ m ^l ιJι ^ ^- ιn D ^D ω m H ιΛ σl ιn N W cD ιη ι^ σl σl (η w co N H to o u^ Λ (η w H H n ln ω cn ^ o » ^ l ιn ^fl co m cn (!l O N m H oo r^ o ^ H C?ι H H ιη θ H θ N io ω σι oι ω w ω io

u -o uo tn ιn ι/ Lθ <Λ © ^ ^ ^ !jD iβ r~ r- r~ r^ r^ r^ r~ r~ ∞ ω cD ∞ oo rH rH i-H CM CM CM n cn ro m ro fo r cη o oo r p o pO oo o r o o o m oo oo oo n o o ro oo oo n o ^ ^ ^ ^ ^ ' ^ ^ c w w w w M w O O O O O O O O-i Oj Oj αi -i i-y Dj i-j ^ ^ ^ ^ j j co j ϋ O O O U -i i-i ^ j _| μ] ₁ l l-_J C-, CU I-j C-ι CLι (-j (-j >-ι >H >-. H H H M H H C^ I^ C^ Ctf lI OS W W W O W W W W rJ hH rH rH ai a^ ι ι ι i ϊ i ϊ θι i- nι i- ⁽iftθι (i; rt; (i; «i «ι;uϋ oS S ι^;i l l<(il < ;> > ' > > ' "> -> -> rt "; " " rt "; sc " " rt ^J; Kj ^J; e) u e ^"~) cj Q a ω ω ^Q < CO O < CO U Q Q KC <; co o o (< 03 U D Q o υ z υ z o o z υ o o u o z u u u o o υ o 3 u o o z υ υ o u z o z z u o s υ u υ υ u o z u u u o o υ o z - co cn

tf tf

Tάβtil

ATOM 220 O GLY A 42 69. 042 32. 781 111. 663 1. 00 34. 04

ATOM 221 N VAL A 43 69. 979 32. ,913 113. 707 1. ,00 31. 48

ATOM 222 CA VAL A 43 70. ,277 34. ,334 113. 626 1. ,00 31. 31

ATOM 223 CB VAL A 43 69. ,081 35. ,211 114. 037 1. ,00 31. 65

ATOM 224 CGI VAL A 43 68. ,090 35. ,255 112. 932 1. ,00 32. ,00

ATOM 225 CG2 VAL A 43 68. ,446 34. ,680 115. 327 1. ,00 29. ,54

ATOM 226 C VAL A 43 71. ,391 34. ,689 114. 578 1. ,00 31. ,62

ATOM 227 O VAL A 43 71. ,384 34. ,269 115. 725 1. ,00 32. ,45

ATOM 228 N ARG A 44 72. ,330 35. ,501 114. 120 1. ,00 32. ,59

ATOM 229 CA ARG A 44 73. ,430 35. ,900 114. ,978 1. .00 32. .23

ATOM 230 CB ARG A 44 74. ,634 36. ,305 114. ,133 1. .00 30. .10

ATOM 231 CG ARG A 44 75. ,173 35. ,165 113. ,321 1. .00 28. .38

ATOM 232 CD ARG A 44 76. .442 35. .549 112. .600 1. ,00 29. .66

ATOM 233 NE ARG A 44 76. .916 34. .448 111. .762 1. .00 32. .18

ATOM 234 CZ ARG A 44 77. .421 34. .607 110. .543 1, ,00 30. .72

ATOM 235 NH1 ARG A 44 77. .521 35. .821 110. ,020 1. .00 31. .62

ATOM 236 NH2 ARG A 44 77. .809 33. .556 109. .842 1. .00 29. .64

ATOM 237 C ARG A 44 73. .047 37. .025 115. .928 1. .00 32. .13

ATOM 238 O ARG A 44 73. ,689 37. .207 116. .960 1. .00 31. ,61

ATOM 239 N GLU A 45 71. .990 37. .762 115. .598 1, .00 32. ,69

ATOM 240 CA GLU A 45 71. .573 38. .873 116. .445 1. .00 34. .53

ATOM 241 CB GLU A 45 70. .578 39. .769 115. .694 1, .00 36. .59

ATOM 242 CG GLU A 45 70. .223 41, .025 116. .479 1. .00 41. .80

ATOM 243 CD GLU A 45 71. .440 41, .594 117. .213 1. .00 44. .59

ATOM 244 OE1 GLU A 45 72. .466 41. .834 116. .522 1, .00 46. .33

ATOM 245 OE2 GLU A 45 71. .371 41. .786 118. .460 1. .00 41. .23

ATOM 246 C GLU A 45 71. .003 38, .474 117. .814 1, .00 32. .72

ATOM 247 O GLU A 45 69. .852 38, .092 117. .935 1. .00 33, .26

ATOM 248 N LYS A 46 71. .829 38, .604 118, .842 1, .00 31. .74

ATOM 249 CA LYS A 46 71. .461 38, .254 120. .193 1, .00 31, .44

ATOM 250 CB LYS A 46 72. .650 38, .548 121. .111 1, .00 33, .55

ATOM 251 CG LYS A 46 72. .550 37, .959 122. .516 1, .00 37, .58

ATOM 252 CD LYS A 46 73. .931 37, .596 123. .067 1, .00 37, .72

ATOM 253 CE LYS A 46 73. .862 37 .059 124. .488 1, .00 36, .84

ATOM 254 NZ LYS A 46 73, .418 38 .106 125. .450 1, .00 39, .04

ATOM 255 C LYS A 46 70. .200 38, .959 120. .691 1, .00 32, .17

ATOM 256 O LYS A 46 69. .531 38 .468 121. .609 1, .00 33, .32

ATOM 257 N SER A 47 69. .848 40 .096 120. .095 1, .00 31, .91

ATOM 258 CA SER A 47 68. .649 40, .804 120. .550 1, .00 30, .89

ATOM 259 CB SER A 47 68. .814 42 .333 120. .404 1, .00 29, .98

ATOM 260 OG SER A 47 68. .697 42 .795 119. .066 1, .00 28, .59

ATOM 261 C SER A 47 67. .374 40 .335 119. .853 1, .00 29, .76

ATOM 262 O SER A 47 66, .293 40 .863 120. .108 1, .00 28 .86

ATOM 263 N ASP A 48 67, .504 39 .338 118. .978 1, .00 29, .77

ATOM 264 CA ASP A 48 66, .350 38 .781 118. .262 1, .00 30, .47

ATOM 265 CB ASP A 48 66. .751 37 .543 117. .459 1 .00 28 .93

ATOM 266 CG ASP A 48 65. .691 37, .127 116, .459 1 .00 30, .60

ATOM 267 OD1 ASP A 48 65. .627 37 .727 115, .366 1 .00 32. .23

ATOM 268 OD2 ASP A 48 64. .913 36, .202 116, .759 1 .00 30, .50

ATOM 269 C ASP A 48 65. .287 38 .383 119, .277 1 .00 31, .67

ATOM 270 O ASP A 48 65, .582 37, .714 120, .279 1 .00 33, .65

ATOM 271 N PRO A 49 64, .032 38, .779 119, .028 1 .00 30, .74

ATOM 272 CD PRO A 49 63, .576 39, .618 117, .907 1 .00 28, .94

ATOM 273 CA PRO A 49 62, .923 38, .467 119, .933 1, .00 30, .97

ATOM 274 CB PRO A 49 61. .787 39, .340 119, .387 1, .00 28, .99 ri Pi H ri v m oo iπ w ^ o i/nc r- N iO N w in o ifl iΛ N oinc v ^ r- N W M^ v c iH 'Λ co M C O i^ r- oo ^ '^ r- r Ln o vO rH

O O r~ UD l-3 VO M r~ H O 'q^, ιH tn θ <-300 CM r- rH OO OO in t~- ι-H Ln r~ ^lX3 CM H OO U OO O p- r~ ^r ( tn M '3^, M cn ii) oo oo cn M θo c m ^,-3 o >J3

© *•! OO O O O i-H CM m ^r Vβ UD UO CM r O O VD CM O iH m o o O H N in o o oi ino in iD co tD m o iΛ to o o H m eo ffl nnD ' ^ ^ iO iD

O CM OO OO OO OO OO OO OO PO OO OO OO OO OO OO CM CM CM r rO C rO OO OO OO r OO O OO CM CM CM CN CM CM CM CM OO CM CM OO rO PO CM CM CM CM CM CM CM CSl CM CM CM oooσoooooooooooooooo ooooooooooooσoooooooooooooooooooooo

H oooooooooooooooooooσ ooooooooooooσoooooooooooooooooooooo υ

N ln tJi r-

^fl o u) o^ H (ι w ra o H ln o ^D m ^ H m N ln D ^ π o ^ ^ oo ^ (Λ co N O (^ I») ^ Λ W c ^o ^ ^ H f H 09 W N (D <l^, ln (η H ^ι o) H <ji (fl θ H θ H N (c o ^ o m θ irn ιo to ^ ιn iJi o iD ri ιfi ϊi π H ιri N ffι ιn ιθ H H θ (iι θ ιn H H (n * «) (Λ H θ ιn » co ιn ιη fl M tfi » σl ln ^l ffl ι ω ^ O H n tD a ( l ^ <J o r ^ ro f α) Λ o o c^ι n ιn ln ^ H H lo ^ ^ ω H co n ^D !^l OJ _'» ^O lB H l») σl ^ ^n ^ ^ ιn ^ m ω a v ^ ^n w ω ^ ^ π (ι « (o n ( ln ln (l H ι^η (^ι ιΛ ^n w ^ oo H H O (Tι eo oo ^ <D ω (Λ ^ ^ ^ ^ (B (Λ ^ ln ln ιn m n ^ lη lfl ιπ ^ OO OO OO OO ΓO CO CO ΓO OO OO OO OO OO OO OO OO OO ΓO Γ Γ OO OO ΓO ΓO OO ΓO OO OO OO OO OO CM CM CM CM CM

WJ o m m oo o uo o cM rH O r- o ri ^ Λ o ^ to m ω oi m ^ rii αi r o n oJ co iJi o w oo ω io m io o N r- in r- 'ii' M en CM LO CM co >-D -sr

CO OO iH rH OO σi OO r- CM rH tn CM -., π w w 'J H Φ H ^ o ω in i i^ ci ^ r 'w ^ ^O f αi fi M r- M eo ^ ii D r- CM r- ^ r- o » n oi o o m o co ^ MJi o co o cn m D cn o r oo 3 ιr) oo oo CM p~ ¹-3 H θ oo r~ ι-H θ ^r ^,^ rH θ r~ o r- OO H oo r- VD en ■sr en en en -sr r- o

N N Cj N N H θ H m m o ιη nι v ιn ifl r~ co ιr) ϊi _'a' V 'i^, ιn ^ ιo ιn ^ j ^ 'i^, ιn ιn (D ^ ^' <r co < H H H

Ifl ω ω W VO Ifl l-l lfl kD lfl ω ω

Ol Ol JI O O O O O O O O O O H H H H H rt iH H N N N N N N N N N n rl n fl l'l l'l f'l l'I V fl V ^ V ^ ^ ^ 'l' IO lfl in ifl in in in in

^ v <ϊ in ιn ιn uι uι uι ι iΛ Λ in ιn ιn ιn ui ιn ιn ιn ιn ιn ιn ιn ι ui ιn iΛ in ιn ι ιrι uι ιn ιn iΛ in iΛ tn ιn ιn ιn ιn Λ ιn ι^ tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o oow ϋJw ω w w wOT ωw ω ω ω ω ω ω ω w t M w w w w OT w cΛ D D D D DD D D Z z z z z z z z D D D D D D D D

B! B! P5 H H H H H H _h-i μi _{1- 1} | ₁- | ₁ l hH H >H H >H >H ^ H >π ι cd w ω ω w ω ω ω ιJ Hi hJ hH ^ hH H HH hH w ω ω w ιa ω ιa t-) ⁽- di αi K E s ai S K Ϊ Ϊ Ϊ Ϊ H H H H H H H H ^ ^ j i

(j tf pQ o α α ω ω B O Q tf m C3 Q w N tf CO U D Q tf CO CD Q W ω tf OQ U Q D o υ o z u u o u z u z uo z ou υυυ υ o z υ u υ u u z C O Z J CJ O C CJ O ozooouozυozυuυuυuo ιn w ^ o3 σl O H N rη ^ ^n w ^ o ffl O H ι n ^ ln w ^ ω m o H N t^ ^ ln ω ^ (xι ffl o H ( ^ ^ ln ^fl ^ m m o H N o^ "» l ^fl o: Il

^ ^^• ^ ^ ⁽00500 ^[D OJ I10 C0 30300 <Λ 01 ⁽Jl m m ⁽n ⁽Il lJ ⁽Il ⁽Λ O O O O O O O O O O H H H H ri H H H H ri ( M ^I ( M ^{l ( (M !l ( CM CM CM CM < CM CM CM CM r) CM CM CM CM CM CM CM CM CM < < CM CM Cl CM M r 0 rθ rθ 0 0 O0 r0 O0 0 rθ 0 0 n 0^ so o 2o2o2o2o2o2o2o2o2 22 o2 2 E^HoE^Ho2 o 2 2

E^H E^H H ^H H H H H EHo2 EHo E_fHo2 Etf^Ho22 Et_f ^Ho t_fEHo2 tf^Ho2 tfE^Ho22 tM_f EtfHoEtf^H Eo2 tfHo22 tH Eo f tf^Ho222 H o tf Eo t_fH EtfHo2 EtfH Eo2 t_fHo tfE^Ho2 tfEHo2 EtfHo2 2 t_fHo2 tfH EtfHo2 tfEHo2 EtfHo2 tfEHo2 Et_fHo tfEHo2 tfEHo2 Et_fHo2 Et_fHo 22222222 9 f tf tf tf tf tf tf tf t EHo2 EHo2 t EHo2 EHo f EHoEHoHoEHoEHoHoEHoEH o tf tf tf t

θ '3^, ^D ^r oo c ι-H σι r- C c co co Ln r- o u '3^, r M 3^,ι M r~ r- r- - o σi ^ in H i o vD io j O Λ ω to N m m fn n w n ω ω n σi H m m Λ co N o n w ω in f σi in co OO r~ «a< CO OO 0O CM C^,0 '3' iD σi ^r u M Ln m m o r- r^ r^ σ^ ri rH m ijp o

© ^a ^ ω w o ∞ m ω ra m o H H O O H ^ ιn ^fl ^o o n ln cn ω w oo N ω ^ ^ ln l fl ^ ιn ω O '<l^, ln ^B ^O !l tΛ o o o o (o o^ oo ln ω r• ^

CΛ M C C C C M M Γ <^ O O <^ ΓO ΓQ CO OO (^ O Γ O OO O ^ ^ ^ ^ <^ Γ C ΓO Γ Γ ^ ^ ^ ^ ^ C^

5 H oooooooooooooooooooooooooooooooσooooooooooooooooooooooo

U ooooooooooooooooooooooooooooooooooooooooooooooooooooooo

CM ω H ^ m N H » l o N ^ ω ^n n o ω ^ (η ^ l (^ι w ^O '3^| f H 'sl' co ^B (l «l H m ιJ' o (^,) u^ o o o3 '^f ^ ω o ^ H H ^ ^ ιn ln σl ω w o o1 o ^ O N ln ^ p^ ^J * ι fl ω tD ι ω o c^ι m Λ <^ W 'ι o ^ (^l H (n ^o o m ^o co o l!l ^ (Il o^ O l) « ln o H (^rι ^ ^ ^l f (^ι H ω w m m N m m Λ oo o o N N O « Λ H (Λ ln (η H v o <l^, ! ^o o lΛ ri H l oo co ιn o ^ N ^ (J^ H (η ^o o ^ lr) ^ o3 ^ ^£l ιrι (η m cI^ CΛ

(D σl ιJl O ( N ι σl o H H N rt N O O <Il (I) m <Λ O H l H (^l H O O Λ O N H P^ (l (^,) ιn ^n ln ιn * ^n H O H σl co (D ^ ^ ^D ^ to ιfl C_M CM CM O r ^ o cM C c r ro ro M c CM CM o ro fO M o r c rn r ^ r M o o r M iH iH iH iH iH iH i-H iH iH i-H iH i-H iH i-H iH iH rH iH iH rH iH rH iH iH i-H tH i→ iH iH rH iH iH rH iH i * ^D cD n H H N W ln ^ (o » σ (D H ιn ^ ra H ^ ^ (η ω ^ cι ω H O <ι ιn ffi tB co v l^ oo co ^D oo σl N σl ri ^fl ι oo H (^fl o ^ t^ ro <Λ ι l o o o n ^l lΛ o ^l ( (O H (^^ tIl n f (D o n ^ H σι H ^ N ιn ^ ^o ol ω o m n lfl ( M ω ^ m ^ι ^D ul ^ H (η u! r ^ι ^ ^ o o W _'τ n ^fl ^ O (n ^ n H ιn lΛ H oo N ω N f^ m oD O N ∞ N ι ffl σl ιn N ^ ι o H σι (η ^ r^ w ιn r1 Φ H ιn ^ ln ιn w ∞ ^-• (l 'τ o^ ^ o ^ o

CM ι-H rH H H θ o σι σv oo r~ r-- p- vD Ln -! -!i' r- in ^ oo oo cM rH rH cn cn cn oo oo cM CM rH rH O O oo en en CM

oo i-i βi n

N N O O O O H N N N n ^ N H rl O O C0 C0 (II (0 H O N n (\l (^η iΛ PI V ^ lf) ιn il⁾ ^ r- C0 Ol O O H h 00 ω r 00 lβ in ^ l^,) in ^,J * <l^l

^ a ^ ^φ a ^ ⁽D io «) ^ ^ ^ ^ co co o3 (D θ3 co co ω o) tn (jι m (Λ i3i (n σι oi !Λ o o o o o o o o o o θ ri ri H H N t\i (\i ( N rιi N iη Ln -o -n in in Ln -n ifi Ln Ln O Ln trj Ln i/i LO -n n in in tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

1-3 tf tf tf > >

CM CM CM CM rH CM tf m Q w ω tf O tf CO CJ α ω ω tf O CJ Q ω ω tf CO J Q ω CO -C a tf z υ u u CJ o tf to CJ CJ z υ o z u u o o Z o CJ υ o o υ o z υ o O υ o o υ o z u O o L) z o Z z o o ss CJ O O z CJ o O o U o S3

O H N c <^ ιn ^o ^ ω <!l O H N O ^ ιn w ^ ro w o H (^ι n "if ln ιfl αl m o H C ( ■r ιn >o ^ oo ι^ O H N n ^ ul « ^ co (Λ O H N rn ^ (0 (o n n ⁽ o^ ⁽η ιη ^p^ fη 'τ >τ ^ ^p v ^ v ^ ^ ^ ιΛ ιn ln Λ ιΛ m ι/l ^n ιn ιrι ^D U ω ω ω ω ^ ^ ^ ^ ^ ^ ^ ^ ^ ra ω co ω co oo oo oo oo ro m oo n oo n n oo oo ro oo ro oo c oo ro rn ro r ro ro oo ro oo cn oo ro oo oo n oo cn oo oo oo o^

2o2o2o2oo22oo22oo22oo2o22o2o2oo2o2o22oo22oo2o2o22o o tf tf tf tf tf tf tf tf tf tf t_f tf tf tf t_f tf t_f t_f tf t_f t_f t_f t_f

D o

o o w o o ΓO P- CM Γ- OO O O OO O N f O N N T t- N 'J M O H r io in n r- in r a io r~ r^ cD in ι p co ι ιn υD ^ ι o c C CN ιH o cM i' (η ^ ^ ι ι co ^ M ιH M Ci ( ^ ιn > vo n ^

CM CM CM CM CN CM CM CM CM CM CM CM C CM CM CM CM CM CN CM CM CM CM CM CM Csl C CM CM CM CM CM CM CM CM CM CM CM Cl CM

N rι co N iii L O H H ( ι (Jl H fll N (η

^ σ^ ∞ ffl ω ^ σl CΛ m o H H ri ι ^^ ^ N ri r n 'ϊ ιn ln lfl ω ^ ω ^ ^ ^• [D ffl Ol O H tl (n H (^ι l n q' '^' ^D ^o ιη l H H O O o σl o Λ ι ^ H ^ ι σl n (^ Φ ω H ω Λ ^ι ιϊι ^ o ^ π^ o ^ ^l ra ln o ιn c^,^ (^ι ^o α) co oo ^ o lJl ^^ cIl O H ω H ■ϊ Λ ^ ^ (] co co H H ^o ^S ιn m H H N H σl ω ffl H N H 'I ( H co ^ t^ ^ ^ ^ ιn l N ^o n ιη ω H N ^D ^ rt N H l H ^o ι ιn o N ^o ^^ r- co H m ln N O H H CD ^l H c^ Pl N H ι» ιn ^ ^n H (xι H <lι ι ^ ^ H o^ oo ln oι H O O ^o oo ln ω ^ H (i c^l tO H (Λ H O H ^ [ H ∞ o o ι^,) ι3^ ιIι tn ^ N ln ln ω o ^ (o

« ln ^o ιS Iη r^ N H O ffl N N N N (^ ^ ^ ι^^ H O H O (Jl ^ ω ln '» O H ffl o ol ω m σl o m o o3 ^ lI> oo o co ω lfl ^ w ^ ιn v ιn ^ (η r^ι l > i£> lO ^ VO CO ^ l^ v > L VO \O ^ ^ VO ^ lX) VO CO O U3 VO i LQ

n n r σi n^η n ^ ^ ^ ^ ^ ^ in in i in in i in i a ω iD ω w Φ io w ω ^ ^ ^ oo m c oo co oo tij βi w σi m w Λ o o o o O H H H H tf tf tf tf tf tf tf tf tf tf tf t_f tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf t_f tf CO CJ CJ tf CO J tf CO CJ CJ Q tf PQ CJ Q W tf tf CO ⁽J (J tf to cj υ υ u c u o z u o o υ o zuuuuuu tf CO tf CQ cj

O Z υ o υ υ υ z υ o z o z uuuuυ o z υ υ o u o u υ o zouu l ω ^ cD fll O H ⁽l M ^ ln w ^ o^ ⁽Jl o ^^ N ⁽ ^ ιn ^ ^ ω σι o H l ⁽η ^ ιn w ^ o^ tFι O H N ιn <^^ι ιfi ^fl ^ ra m o H c^l (n ^ ιn ω ^ ra cfl

∞ C003 <B C0 (J10> (Λ (n (Λ (Λ 01010 σι O O O O O O O O O O H H H H H H H H H H ( t ΛI N N N (v| ( Cl N (η iη n m iη iη iη (η rn i»)

00

© 2oo2o2o22oo2o22o2o2o2o2o2o2o2o2o2o2o2oo22oo2o22o2oo22o2oo22oo22oo22o2o2oo2o22o2o2o2o2o2o2o2o2oo22o2o2oo22o2o2o o tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

ι o ( H oo o

>3' 0 H rH O O C0 r~ ^l ' m m L0 ^■«3' O ι-I O O rH CM CM 0000 m 'q^, C0 σi 00 Cn 00 C0 r~ >J3 00 C0 00 C0 1_3 U3 L0 O N o H o^ ω ^ u) W ^ ^ ro ^ ω ω ιn ^ ^ o M N (η f^ ( N π (η N c^l (N (ι cl H l ιH H o o m <I^ (c m ^ w ω ιn w ιn ω ι w ιn ω ^- ^ ^

CM CM CM CS] CM CM CM C\I CM CM CN CM CM C\) C<J Csl C C CM CM C\I CM CM CM C\I CM CM CM C CM CM CM C CM CM ra ω ω ιn H

<^ι l ^ fl ι ιn ln ^ ln M N (^l H ^ oo ^^ ^ ^ Φ Λ ^ ^ ^O lΛ ^ m o^ o o (^ι ι^,) n ^ o o o o o30 H H ^ι (^ o^ ιn ^o o o o ! l Oι m ^ ιIl ιn o in i i in i Ln i- i i LO i in i i Ln i i i i i in i i i i i vo vo ^ vo co io co ^ ^ i in υJ vo o io vo ^

i-H rH iH rH CM C CM CM N ^{( (}\l N ^l N ts fo n n r ιη ⁽η r^ ⁽η M M ⁽n ⁽η « « ^ ^ Hf l' ^ ^ ιn ln lr) ι ⁾ ιn a ω ^ ^ ω ω ^^β ι l ^ ^ ^ ^ ^ ^ r~ r- r~ r- r- r- t-- r~ tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf Z Z Z Z C O C O CJ U U O O J O tf Pi tf αϊ Pi PS PS αl ff 0,ϊ P0,, 0, , >_* >_* > >-, > ,

Q Q tf cQ CJ Q t-l cO ac aα ^ W O Q W Q W N oz ozuoυozu tf CO CJ Q Q tf O tf CO c Q ω tf to CJ α ω z z o o z υ u u o υ u o c o υ o z c c u υ υ u o z υ u υ o z υ c u co c c o U U U U U

o22oo2o2o2o2o2o2o2o2o2o2o22 _fH Etf^Htf^H Etf^H Etf^H EH EH EH EH EH EH EH EoHo22 EH EoHo2 ^H Ho2 &H Eo2 t_f t H

ω <^ o N ^ r_' <ι^, ι^,) H N H In ^- H (rl ^,q -^, " -3.' in "a¹ -sr CM CM CM CM CM r- O rH f rH OO OO r- o ι- cθ rH o Ni H io σ> < 'a^, vo m (!^ tD ^ tD ^!) ιΛ ιn ιr ιn ι ιn ιn ιn

tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf t_f t_f

CO CO D D D D D D D D D 04 CM X >H HI H1 H1 H1 H1 H1 H1 H1 I-1 co O CO CO CO O O J HJ J CJ CJ CJ CJ CJ CJ CJ CJ tf tf tf tf tf tf tf

CJ O Z J O ιn ιD ^ ιx⁾ m o H N n ^ ln ^ ^ co ol O H ^l (η ιJ ιn ω ^ ω ⁽!l O H (^ι ^ ιn ^o ^ co cIl O H ^ι n <l^| ln ιfl ^ m (Jl O H N (η <l' ιn rø cD (Il m ^ oi σi m o o o o o o o o o O H H H H H H H ri H H N N N N N J N N N N n r iη tn iη m iη σi i'i n ^ ^ ^ ^ ii' ij * ^ ^ ^ ^ ^ ^ ^ ^ in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in

2o2oo22o2oo22o2o2o2oo22o2oo2o2o22oo2o2o22o2oo22o2o2oo22o222222222222222222222222 EtH EtfHftEH EtfHtfHtfHtfHtfEHtfH EtfH EtfH EtfH etfπ EtfHfE E oooooooooooooooooooooooo tfHtfH EtfH EtfH EtfHf tHtfEHtfH EtfHtfEHtfEH EtfHtfH EtfHtfEH EtfH EtfH EtfH EtfH EtfH EtfH EtfH EtfH EtfH EtfH EtfH EH EH EH H EH EH EH EH EH EH EH EH

O

(B ( ω ιD m oo lΛ H in in D oo oooo oooo

ιn « ln ^D H r- H co co cM oo ∞ ω ul ^ N oo ιn H

^D ^ ^ ^ co ^ «) co ttι ^ (D ^ O H (!l H H O H O N ι n m ^ H l O O co ro o) O ^ o o o flO (lo eo (^ (I^ (D a) ^l) lΛ <l^, '» tn co (D Ol O H ri H H ri H H H H H H H H H N N H N N N N W N M N N N N N M N H H H N N tSI N M H H H H H H H H H H H H H H H M N ₁-H iH rH iH rH rH iH rH rH rH rH rH iH rH iH rH tH rH iH rH rH iH iH iH i-H iH iH iH iH iH rH iH rH iH rH iH iH iH rH rH i-H iH r^

H H ιn ro ω H m ιn H

CM CM ι-H O OO ^' 00 *3< "3^, m r'- Co σ> OO T CM ι-H O O O O Cn oθ Cθ r- oi r^ r- ω in in in ω ^ in n tM H O H σi O M 'j ^ ^ ci n ^ iη m io ω r- CM CM CM CM CM CM CM CM CM CM CM CM CSI CM CM CM CM CM CM CN CM i-H rH i-H rH ιo ^ r vo o ι→ ^ D o n r~ CM co c c ^ ιH σi ιH rH H oo σι r- oo ιn 'a^, o c θ rH ^»o ιo θ rH r-- uo cM o σi r^ σi ^f in cn iJO o r- vo i m oo tn rH Λ ιH O 00 00 O V0 l~ <Λ ι-H 00 t^ rH in t^ 0^ ιn r0 O β 00 ιH CM 00 θ m ιH C0 00 ιn V0 r0 r~ 00 CM H ^« cn ι-l r^ vo Nj in io N O ^ σ r- cri ro σi r- m o o ^ (^,1 !^ ^fl ^o ιD ^ oD c _H^^ ^ ^ oo "_f n ffl ^ tn co ^ ^ H ^ ^ n c^l H O_l ^ o ^ι rl O 'n β n -^ T ^ r- r- ω oo ^ o N N ifl v tη ω n H ifl ^ ^ n r v oi H o oi o m fi H H H H W ^ N N tNfO 'ϊ in ^ ro i ^r i'i m in N invDin ωio ωinw r- co r^ oω oo t^ W r^ σi o co σi cD ι ιn m m m m m ιn m '3' in '3> ^r i in in i ^ ^ i in in in i in i in in i i i in i i in i i in i in i i i in i in in in i in in o in i in

ul Ul ιn ln ιn ιn ιo φ ιo ιo ιD ^o ^D ^o ιo ^ ^ ^ ^• ^ c tD co co o ID lI) Ol m ol Ol ^Λ <Il <Λ o o o o o o o o H H H H ^^ H H rl H ^| N (^ aa oD op oo oo aD CD CO co co oo oo oo oo ∞ co co oo oo cxj oo oo oo oo oo oo oo oo oo co oo co oo co co σ^ σ σi cn cn tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf pS pS PS O OS oS co c CO CO O CO CO C DS oJ Oi CS p PS HH Hp iJ H^ H H-q j i- P pS o P P ai ai ai -i &i j i O-i D ΪO D D D D D D D CO ω ω ω w w ω x x x x x x x x x ω ω ω w w w tf tf ι=t! tf κ tf tf m aci tC K -C K K co co co co co co co co

CO C CO C C Cθ HH i-H H H3 HH H HH i-5 Hq CO C CO C CO C > > > > > > > EH EH EH EH EH H EH tf tf tf tf tf tf tf tf CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ υ tf CO CJ tf co cj a C co tf co cj tf O tf CO CJ J Z O CJ o o o J CJ J CJ u o z J J O J CJ tf cQcj Q Q tf co c o ω ω tf m

Z CJ CJ CJ J CJ Z CJ O z υ υ o υ o z CJ J o z υc υoooo zooc υo ouo zc cj

O H c^l ^^ ^ ιn w ^ o3 5ι O H w π ^ ιn w ^ o^ m o H N ⁽ « ιn Φ ^ oo ^ o H ⁽^ι ιo ^ ιΛ a oo ι o H ^ι n ^ ιn ^o ^ oo I^ι O H c^ι n '!r ^ln ιn ιn ιn ln ln ιn ιn ιn ι a ω ω ffl « lD ω a ω ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ (χl o^ o3 0 t» (X! m oJ ra co m m ⁽Jl 0 w σι o^ o σ σι o o o o o in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in uo in in in in in in in i^

00 22 2 2 22 o o O O O O 2o2oo22oo22oo2o2o2o22oo2o2o2o2o2o22o2oo2o22o2o2oo2o22o2o2oo22o2o2oo22o2o tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

© o

co ^^ι m ^ ^ n ^ n N W ^^ ιn (η ^p ^^ m (Λ (n ιn ιn n co ω N (I) ^ o r^ ^^ m ^ o^ O N co lrl O Λ H ln N c^ι c^l

"•ft r^ r (^ r^ o M ^ vθ ιH i oo uι cM ^ ^,tf CM ^ o r^ ^ 'tf ιH θ 'tf θ r~ ^ c θ co c oo ιn ιH v Ln cτι M i ^ r~ r~ oo cM Lθ in m r- vo oo m f> S (η in f H ^ ^ OO ^ N CO H H rl H O O ITl OO ^ W in in O O IJl Ol H r lO lfi in lD W tO I^ OO Φ σi H H t H ^ H H 'if OO N Ol N M iH O β ■^ <η r r M CM CM CM CM CM CM CM O CQ O O O C\] CM CM CM CM CM OO O CM CM CO CO C O PO θ rθ CM CM CM CM CM o

CΛ ooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H υ rH rH rH rH rH H rH rH i-H rH rH i-H iH rH rH rH rH c n o io o ri H in N ii ^ iD oo ω O f H ^ cD fl' W o r- wn i' a i ifl O _d H in n' N ω o ^ in in oi ifno rH oo - o r- 'a' rH H H in c D ^- m ^ ^ ιn v n Λ ^ ^ ^ o o (ι ^ n ro m o H in ^ io in ri oi

O H N H N fO " ^, ro ι ιn vD r~ oo crι r~ vo [-~ ιn y3 iJθ ι '<3' '3' Ln >o ιn ιn rH CM CM CM CM CM CM CN CM CM 0M CM OJ CM CM CM < CM CM CM CM CM CM CM CM CNl CM CM

H ri H H H H o oo o v M n CM 00 00 rH r~- 00 r- r— in m ^ <a< m ^> LO •w uo uθ '3^| ιn m ι ι r~- ιo oo ^ oo oo ι L ^■cr oo c rH O i-H OO o σi Ln in m vo r- cn o en rH co i vo m ^r r rH CM rH CM

M M CM o r o o r o o r (^ r ^ 'tf ^ "W "» ^ ^ ^ ^ "^ ^ ιn ιn ι ι ι ιn ιn ι ι ιn ιn co ιo ι_3 o vo vo vo ^ σ_> τι c Do cn <τι n n σι c c cn cn ^ cΛ <Do σ^ c^ (yι σ^ σv σι cn c σ^ cn cτι σ^ σi c <τv c tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf w co co c-i w c-i ω c-i cx cxi ω ω ω w ω ω w ω w ω w ω w ω w ω w ti w ω i U H U U D D D D D D D D D O U a U O tS U O U U _k-C 3C _t-C _k-d! i-J j - - - - - - - OS PS OS OS υ υ u Bj i¹ι iι C- θ a- o< (ij a, n aι θ4 aj j ttj θ4 θj θj i) (ij θ_J (iι H iiι θι aι (iι (i) aι (i_J CLi CLi di CJ CJ CJ CJ CJ CJ CJ CJ J tf tf tf tf tf tf tf tf tf rH CM rH CM CM cj tf cQ cja a ω ω co tf CO CJ Q Q Cxl DQ CO tf CQ CJ D Q Cd Cd cO tf co c a ω ω tf Q CJ Q Cxl cO X aC

CO CJ O Z U CJ CJ CJ O CJ CJ CJ U O Z U CJ U CJ CJ U U CJ CJ o z cj c c o υ υ u cj c o z c o cjcj o o c o CJ CJ CJ U Z U Z Z j ιn ω ^ ra o o H N ιη ^ ιn w ^ ω m o H N t '* ιn w ^ co ol O H ^ι (η ^ ιn ^D ^ ω l O H c^ι c f u^ ^o ^ tD m o H N ( <!P lΛ ^|£ ^ ω ffl o o o o o H H H H H H H H H H N N ⁽ N N N M N N N iη r ⁽θ i^») t^r) (η ιη (η n ⁽θ '» ^ ^ <' ^ ^ '» ^ ^ 'j ιn ιn ι ιn iΛ in ιn ιn ιn ιn

r- js o © ^ o r- N cn cM ^' o o r- σι O o ι m oo o o cM in σi rH CM in "3' θ oo cM CM r~ o r-~ cn r- cn r~ cn cn c -C Ln r~ r-- oo oo O rH 00 r~- C3n ι-H 00 (30 O

CΛ r m H c Ln c cn ^r rH rH in OO OO i-H r- CM o θ ιH rH Ln oo rH oo o r-- co m oo oo ιo oo oo o *o r~ oo rH CM m ιH m r~ cn rH r~ O rH ro >o M o β M co H O H H co H O H m H n tJ ^ (η cι « w t ln ^D ιn ^o ιn ^ σl σι o ol O Ol ri P^ f ) ^ ^D lfl «) σι o o o Λ αι H {η ^o ιn ^£l ln ιrι

H cM CM M C CM CM CM r o M o o n ^ ro n n oo o o M o c r o r cM M M C^

AH ooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooo σi cθ CM oo oo en co i£i lD N en co o CM en oo OO H H 00 CM r- 00 LO

^■^ r~ H (η <f n t»i ^ι

CM CM CM CM CM CN M CM r^ σι « H 03 ^ n ω o ln ω H lD ι oo ^ o ^ (N ω oo l '<f c H ^ (^ σι ^o σι ^ m oo O H l^,^ r^ 'l' w m 'f O lD O ri O oo ln ^■^ cO '^^, ln ^ ω w ω ^ Λ o ω ^ ^ H ^ H σl ιη M O ^ N OJ OO '^^ι ^D oo o ^ (^ι co oo o <J ^o oo o » o ^ oo t ^D u^ ^ l-l H ιn o ιf) O H lfl o r^rι m ^s vB ^ Λ a) n σl <Il Φ O ( N ln co ^ N O ^ cD ^ O H (Jl o ^ a) H t^ Λ » co ω ln ^ c^ι n ιη w oo ω o H (^ oo o N HJ ^β H P^ l ^o m ^^■ n lrι (^,l

^ ω ^ ιIl (D Ol σι ^ w ^ ιo Φ ^ ιn u^ ^ lD ^B ^o ^ ιn ^ o3 (^l ffl o ffl m o H O H N H O cl ( π H H H π ^^, ιn f^ ^ ln ^fl O (Jl r^ O H

H H ri H H H H H H H H H H H H H H H H H H H H rl H H rl rl H H ( ( N M ( CM M N N M N ( PI N ( ( (M « N M ( H (\l N ( to w σi ^ n ω ω N r- N i oo o ^ H ci tD 'O' ffi N H W tM W o cD N M in H H M N H m io in oi H oo σi ¹ >£i o cn cM oo co oo m o ao vo oo o ι ^ H co N ω ^ <r ω ιn oo « m o o v σι σi rf n oo ^ ^^, σi (jι ι) H oo <Ji ^^, cι| 'v N (Ji N m <ii N H in ω H co oo ιn cn i£) rH i_3 oo m m cM r cn 'ϊ θJ θ ri ιn (n n N iD βnβ N H ft θ H H <f n tci H θ io pi (M r- tD i r H [~- σι σι <ι o ^^, σι ιn r') (^,ι r-- ιn cn ιo σι r- o r- rH r cτι r- Lθ ιn ιn ^ ^ co ω o3 oo o3 m Φ m co co ^ (» H H N ιη ^ ^ ^ al n ^ ^ N H l (η » ^l H N l^,) n ^ o o o Λ Ol o m o ^^ ^ι (^l o^l aJ 03 ^o ιn <» ^ ^ ^ ^ ^ ^ ^ ^^■ ^ ^ ^ ^ co ω co m t) (D oo (lo ω m (o ω oD ra oo ω ω m (rι (» co o lB oo ω ^ oJ r- (D aJ co ω oo ^ ^• ^• ^

^ ixi t os ω co oj ∞ co iJi m σi tn m m m ji m o o o o o o H H H H H H H H W N tN N N N N N n m n po π n i'i n r'O f oo ^ 'j' ' cι σ^ σ* σv σι σι σι σι <3o σι σι σι σ^ cΛ < ι σι cn cn o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o

H H ri ri ri H H H ri H H H H ri H H ri H H ri ri ri H ri ri H H rt ri H H ri H H rl H H tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

CJ D D D D D D O D D D D D O D D D O D QS OS OS OS OS OS Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z ci H u ω ω ω ω u u j j Hi X X X X X X X X X X X X CO CO CO cj cj c cj c c c co co co co co co tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf EH Eπ EH Eπ EH EH EH EH EH EH EH EH tf tf tf cO K tf PQ o z CJ O υ O Z U J oo rH r-

o22o

-t r- iH M ^ c o ^ ci i-H iH r~ ^ M [^ i oo oo oo oo M O ^ in o cM O iH io o i i c co r~ c oo oo in ^i> oo o o CM rH oo cn o 'Λ O cn o ^ O f> oo ιn o ιn t~ 'tf r^ M "tf M oo oo oo o θ ιH ιH in "tf 3 oo ^ o co co vo o r~ o ^ r-- c 'a' ι-H ι-H in o c ^lo r~ Tf lO ^ H lD UHO O lHO js

© ln Φ ^ ιn ^ ιo ^ co o m ^ ιo ^ ( ι ul (O H O O H H ι o o H t^l (^ι ^l 'J^| lD ιn ^ ^ (^,1 '» 't ^fl ^ Λ ^ l/) o ι ^o ⁽I (η ^o ^ tD (^ ιη 'S' <l' ln © 8 CM CM CM CM CM CM CM CM rO Cj CM CM CM CM CM CM CM CM CM CM CM CM M M rO M CO r OO r OO OO rO CO OO OO OO OO OO OO OO ^ ^ ^ o o o o ooooooooooooooooooooooooooooooooooooooooooooooooooo o o o o ooooooooooooooooooooooooooooooooooooooooooooooooooo

H U oo o

UJ lO lO CM rH CM rH O rH O iH CM O O O ι-H OO r tH OO "a' in oi m o ffKH c m o o o N ffl o m oj icno ffi co o o N m ^ ^ inD in o o o efni oo r— CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM

CM r~ oo ^r '3^, o cn o m o ιn ι-H θ oo ^r oo r~ rH θ rH rH oo -α^, m oo m o ^,<3ⁱ oo 00 ι-H rH O O 00 r^ ^<J3 n '^^, yi ^,3^, ιH r-- O 00 rH ^■qi <£> en o rH θ r-

OO OO CM Cn oO VD CM -q' OO OO r-- ^r oo o m r- oo en cn cn cn vo oo o r o cM ^ LO O r- o -5i' ιn r~- θ ι-H ⁱ-3 oo co oo cM rH σι cM CM ι ιo r- o r^ n '3' M rH io oo •q' rH oo o cn cn r- r- Lo m oo r- i-H m ^t' CM O CM r— o ci o m os ^ n o H H H ft O H v m H en m o oo in r- ■=!<

'■o r~ r- OO CM rH O Cn cn Cn -O' CO r OO OO OO CM rH CM O rH O O O r-H O rH O OO O Cn O oo ιn ω (o ^ o^ O ln ω ^ ^ ^ ^ H m r^ ^ (o ^ ^ (Jl H (!o n o H n cl « o * m <Λ '» ιf) ^fi H ^ ιn ol ri ^ ιn ^D H (<l co ^o ιn o ⁽J^ t (Il ιn ^ σi in iO N to o in o ω m n oi O 'ϊ ω ^ oi oi N t'i iJi σi iη ^ o σi iη oi o o iΛ in i N r- iB rt N iη iη in iri o o iB m iJi i ^ H h H 'sp o ^ ω ^D M ιn ιn o ^ ^ H ιn n lD n^ ^ ^ o N ro N ^ (Xl ^o o^ ιn ( 't^, D oo H ^l N O ιn ( m ln H ^ n to ι ^ 'l' ^ tn ιi^ o n ω oo H ^π H

^ ln m ιn ιn ^ '» ^ <^ ^o l (^l H o ι3> (Jl (I) m o rl O O <n ol Ol (Jl O O H H H O rl co ^ ^ ln ln 'I U1 lO H( ^ n f) ^ι H O H ⁽n ι») (») ro f^l H

^ ^ ¹ r ι ιn ιn ln ιΛ ιn ιn Λ ^D lD ω ιcι ^o w ^o ιD «⁾ ^D ^ r^■ ^ r- ^ ^ ^ ^ ^ ^ r- o ro oo co oo ω ⁽Jl <Jl ⁽Jl tΛ σl σι ⁽Jl α ⁽3^ m σι o o

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O rH i-H tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf z z z Z z OS OS 0S os OS PS os OS OS S OS OS OS OS OS OS OS OS OS J J J J CJ J J CJ CJ J CJ PS OS os os OS OS CJ CJ CJ J J CJ J J J J CJ CO O CO co co O O O DC X a a X a a X X X X X X X X X X X X OS OS OS OS OS OS OS OS os PS ω ω ω ω ω ω os f tf tf tf EH tf tf tf tf tf tf tf tf tf tf¹ tf O CO CO CO CO CO tf s OS PS PS OS tf tf tf tf s OS OS os PS X X X tf t tf tf tf tf rH ^ rH CM rH CM rH rH CM CM rH CM i-H CM

CJ Q Q tf PQ J CJ tf O J Q ω Q ω CO a tf O J Q ω O a a tf CO CJ tf CO CJ Q w CO a a tf O u O Z J o Z CJ υ o J u o z U J U J J O CJ J o CJ o z J υ CJ υ z υ z z υ o z cj υ o υ o z o υ CJ cj z u z z J o z J J

Lθ ^o r^ oo oo o rH C o <rjι ιn >o r~ oo c θ H (M θ '3' in ^,i⁾ r- oo u oι o H 'tf in ^ r^ oo cn o ιH N M ^ ιn ^ r-- oo c o ι-H θ '<3^, ιn i£i r~- oo c rH i-H i-H rH rH CM CM CSl CM CM CM CM CM CM CM OO OO OO OO C OO C OO OO OO ^ ^r ^ji ^r ^ ai ^r ^p ^r ^ m in i in in LO in in LO i o ^ io co c co io i^ io ijj ^ r~ ^ t^ ^ r^ r^ r~ ^ r^ r~ r~ r-- ~- r~ [--- r~ r^ r-- i^ t~- r-- - t-- r- r-- r-- c-~ r^ r~- r- r- r- r- c-~ r~ r^ r-~ r~ r- r- r- r~ r- p* r~ r^ r- r- r-- r- r- r~ t~ r--

>o ιo ιn ι co co <Λ ιn ^ ro n M ^ o ro o ι ι u3 r^ r~ υ3 co co r-~ ιn '«r c -5i' oθ 'a' o r ι-H rH O i-H rH O <3n o c ^i' m '3' m in ^,^ in *o r- oo r~ r- ^ ^c ^O ιn n (») M M ιn oo cM oo o oo ^r r~ o r- CM cn r _"a< ^r o oo

tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf t_f tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf O CO CO CO CO CO OS PS PS OS oS oS oS oS oS o pS cϋ QS αS oS os ps pS PS Oj αj αi ai αi αi ij αj u pj αH i-j -i OJ OS PJ PS OS OS OS OS DS OS OS X X X X X X X X X X x x a a a td ω ω cd cd ω os os os os ps ps oi P PS PS oS QS os oS X X X X X X X X X X H EH aEH EH a EH a EH a H EH H H EH EH EH H EH EH EH H rH rH CM CM CM

CJ Q Cd CO tf cQ CJ Q txl Q Cxl co a tf CO CD CJ tf CO CJ

CJ CJ CJ S5 O O cj c u υ cj c c c o c o CJ CJ O O CJ o z cj c o cj O S3 c c c c cj c o z c cj c c Z tfJ C^pJ^Q cCJ αC ωCJ αCJ CωJ cCJo aO

O H N t^η ^ ι ^o co m o H N n ^ ιn ^D ^ ιlo σl O H ^ι n 'a' ιn ^fi ^ αι (Jl O H W n^ 9 ιJl lD ιI) m o H ι tO '1^| ι ι ^D 03 m o H ι tn ' r- r- ^ r^• I-^■ ^ r^• ^ ^ r- a) co to tD a) co co co (0 (» Ol (Λ <Λ ιΛ (H (Jl O\ o (n al o o o o o o o o o o H H H H H H H H ri H ^ι cM tι pl M

22222222222 oo ooooooooooo2o2oo2o22o2o2oo22o2o2oo22oo2o22o2o2o2o2oo22o2oo22oo2o22o2oo22o2oo2o22oo22oo22oo2o22o2o2o tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf t_f t_f t_f tf tf tf tf tf tf t_f tf t_f tf tf t_f tf tf tf t_f tf t_f tf t_f t_f tf

O

O

n o in

cn o oo cn o cn oo co n r- ^ ^ 0 0) <I^, CM ^^l Cll (M IO N O ( O U1 N H H (Sl H ri N ^ r" CO ^^, N r( CO H h trι «! (\| Cl O ιn ^fl H ^ fl' H O co oo cn cn cn <^) ι-H rH m <n o in m iJH£i in <» (!i i n tri i») io iC H "t^| i^,) M o i^,) iO H O in co tM H in u) <» o in H iD O H O H O iD n o ii^| H ( i oo in o m oo oO '^r ^ iD io <τ <j n N H θi co «) τ ι ιH H in α) w n σι m ^ o σi (M (ji N ^ o ω ri i/) θ (Ni ιn ω iD H ^ m oo ι ιn ι (θ cn oo cn oo oo co r— O rH O rH CM rH O ^ f W iB ω ω θ H N iη ci ifl «) ιn ^,ϊ (^,l N ^ rθ N N H θ Λ vo ιo <o ιo o o ιo r~ r— r- r~ r— r— r- r~ r-. - r^ i r^ r^ r- r- r- r- r- r- r- r ^-- r~ r~ r_^ r~ r_^ oo oo oo oo oo r-- p~ r^ r~ r- r-- r- r-- r-- r-- r~- r-- U3

l) ln

H H H H tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf PQ CJ CJ tf ca tf Q c a a tf pa cj Q cj co tf pQ cj α ca co a a tf O J CJ

CJ o z cj o c u a o z c υ cj o z cj u υ CJ cj c o z J J U J CJ z tf J o z CJ O CJ CJ Z U Z Z U 02 U U 0 U U 0 υ c o z d oo σι

fi N o o

in ¹ι3' c r-- _O o co o Λ Λ ^ co m n ^ N co in o m io iη pi o in i i^ H H σi Φ m H tn H o co oi W ri in m o M h n ^ iD m σi in N iη ^ ω m ^ o ω ' ω f ιn ln ( O l ιn ιn co o « ιn c^ι N ι (η ln ^ co ffl l o ^ fl ^ ^ ω ^ ln ιn σl w m m cD ω ^o ιo H l ^ H H H P^ m ^ι ιJ> ^|^> (^,) ^ ^ ^ m o σι p1 ^ ^ r o m (^,l m ι ^ m H ^ ul 1' ^^,) O O H N n H ro ')ι ^ι ^ fl ^ H H co ιn ln <l^, o o o o^ o M ιn ^B O (M O H ιn * (^,l ^ r~ oo co oo oo ιo ιn ιn 'tf 'tf o c H ^ ro M M o M ιH rH o c cn o ^ cn co r~ co [~ co r^ ^ ^ ιn ^ "tf «^ oo cM ^f ^p M T i io co r- oo c m m

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM iH i-H CM iH rH rH rH iH iH iH rH rH rH rH rH rH rH rH rH rH ι-H rH ι-H rH rH rH ι-H ι-H rH ι-H ι-H tJl ω m o H (n [^ι o ^ O H ^fi o ι ιn ^ n n (Jι H (η N ^ ^ ts (η Λ ^D o m l H ^ ^ lfl (!ι σι co ιn t ^ oo m ^ N ^o ^ 3 i (\l ι x o ^ o^ o ιn ^n ^ ιn ιo ιc t~ ιn ω H co 'ϊ O ^ ^ ^ N O ^ co o co co ^o o ^ H '^ (D rt co H O (D '» ιn r• H <Iι ιn N f W O ι «• 0 ( ^ ιn ^B (Λ lD N H "^ ιn r) ^ H O (^ H co ω Λ m <J^ ^ ^ ^ι ^o ^ oo ^ H n o o (^ι m ^ "f co o m ^ H ^ι ιn o H (n ι (ι m n N ^ι ^n n co N ( oo ω m (^ ^ m o 3 ffl ^ ιB ω ιn ^ m M N tO (I) m o H N « ^ σl m o (l0 ^ ιp ιl> ιn co o ^ o <Jl O co σι co ^ O rl 0 ι cl H H H H m ^f io ^ ^ io ⁾ iD r^ io i-i ^ iD \D ^ iD ^ ^ iD ifl iD io r^ ^ [^ t^ [^ io ^ vo ^ ^ ^ ^ ^ ^ r ^ ^ ^ r^, ^ ^ ^o ^y3 t^ r^ r^N r^ r^s r^ r [ t^s- r^

ro M r o o ^ ^, ^ ^ ^ 'tf ^ ^ r ^ ^ ^ ιn ιn ιn ι ιn ιn ιn ιn ιn co *-5 ^ c ιo ιo iβ ^ r-- r~ [^ r^ o co co oo

CM M CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM ιH ιH ιH ιH ιH rH rH ι-H ι-H ιH ιH ι→ rH rH ιH ιH ι-H ι-H ι→ ιH rH ιH ιH ιH ι-H ιH ιH ιH ιH ιH rH ιH ι→ ιH ιH tf tf tf tf tf tf tf t_f tf tf tf tf tf tf t_f tf tf tf tf t_f t_f t_f tf t_f tf t_f t_f t_f t_f tf tf tf tf t_f tf t_f t_f tf t_f t_f t_f

Z Z z Z OS OS OS PS OS OS OS OS X X X X oS oή oS cS oS oS co co co co co co co co

HH HH z HP HH •-a x X X X X X X X X X X X Cxl Cxl Cxl W Cxl bl txl Cxl μi ω cxi ω ω w ia x x x x x x x x

CJ J CJ CJ CJ J CJ EH EH EH EH EH EH EH H E< J H1 J HI cj cj cj cj o co cθ HH Ha ι-H HH HH i-a ι-i Ha r-H CM CM tf cα c α w α ω co a tf o Q ω CO tf CO CJ Q Q f tf co cj tf co cj Q ω co c c c o z cj o z c cj cj o υcj oc o cj o z u υ u u cj z υ o z c υ cj cj t CJ CJ o υ υ o υ o CJ O Z U CJ CJ CJ CJ Z CJ o

O H M n <!l O H ( n ^{l (}B 05 IB 03 ( (') ffl (^,1 01 (0 oo co co co

00 rH *S H o 22o2o2o2o2o2oo2o2o2o2o22oo2o22oo2o22oo2o22o2oo2o22oo2o22o2o2o2oo2o2o22oo2o2o22oo22o2oo2o2o22o2oo22oo22o2oo22 r o rH

© tf tf tf tf tf tf tf tf tf tf tf tf t_f tf t_f tf tf tf t_f tf tf t_f tf tf tf t_f t_f t_f tf t_f t_f tf t_f t_f t_f t_f tf t_f t_f t_f tf t_f t_f t_f t_f t_f tf tf t_f t_f t_f o

m co o β 'ϋ' ω o iO Φ '¹ io rH c cn rH r- co M M PO M N N f N fll N f M H oo oo r oo oo cM oo r oo oo oooooooooo oooooooooo

"a¹ in CM -a¹ r- oo t— •u' oo c i-H m σϊ M CM m co rH in oo oo r- co m oo L O i^ CM m in rH oo oo oo m oo cM oo oo oo r- cn m ^ oo oo rH CM oo oo en r— CM r~- oo oo oo cM θ cM ro rH oθ orθo rH in oo ιιnn rr-- ιmn ccθθ rrHH ccoo rr~~ rc—- r rHH oooo iinn oooo oo oo oo o m -a- CMM OO oo cc ooo rrHH iin rr-- v oo co r~

U in iO H H O H •sr o ^ cn m H io m cn r_^ co m c ^ o m co m o o O _'sj' m c r-^ uo vo oo o uo co r- c cn ti> rH in <JD r~ oo m o en o o en o oo oo

(η _h n m oo o ^ ^ H in ιn oι ιn ^ σι ^ o n o o σι m r_^ «! θ ιn (Ji H uι o o ∞ M H co oi (x) h in co ιn H » ι-- ^ θ (N in n H i() (C M ^ (η N ιn n •ϊ O oo '* ^D _'iJ^, m ω ιn ιn ιn ^ o ^ ln <^' W H M O (B l 1' H O O oo (Jl O ^O N f ^ o o ι r- o m H OJ lO H I» o ^ H 01l^, H ^l' \f H ^ H ( ^ l H l ι^^ Cl ( rl ^ o ^ (') ^l H (Λ ιη o ^ ol o^ o o o ιJl H O ( ιn ιn co IJ O lO H ^!^ ^ H eo ^o f^ ιn o >^^, o ιn '^ H (^ι ^ ln ιn Φ ιn ω l!) o o H H

H H H H H H N M M N oo o1 f H N Φ ^ m ω Φ m ιfl n tD m ^ (n o co o w Λ π ^ N W r- u^ n ω '^ n ω ^ ιn H ι H ^£ι ^ H O H (») f H ^ ιn H oo H r^ o (») ^ N o n t co o ι ι o ^ O H ri O ιn Φ H { m ιn co r ι co N ι^,l ι ^ t ^t H (^ ^ ι o ^^ ιη oo ^ o c H ιn ^c> N <Λ H _'J r• 0 _'ϊ σl (^ι ιn H ω Λ O ι ι o ^ ^ n ^ O N ω tNl ^ o n ω ιIl v n N ^ ^ fl O (η ^ ^ c^l N c^l N ι ^ ^ ln m ιo m ω m ^ oD o ιn ^ co (J H ^B O ^• ^ι

N n ( H (^l ^ ^ ιn Φ ^ ^ m o co w (J^ o o o H H N O w o3 oo ^ w ^£) w m o o ri H ^l N (<l (D (D r- ιβ ι ιn ^ » ιn ιn ^■q• Φ ^ ιn ιn ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ r- ^ ^ 03 co cD co oo o30o ^ ^- ^ ^ ^ r■ ^ ^ oo <» (B ω co (D oo ^' p- r- r■ ^ ^ ^ ^ ^ ^ p- ^ ^ ^ ^

H H ι^ H N <^ι l (^l N N ^^{^}ι ^l ι^η ^n ^ ^ 'f v v ^ ^ ^ι^ι "^' lJ^ ιΛ ιn ιn ιn ι l ιn ιn ^o ^o ιo Φ ^fl ^ ^ ^ ^ ^ r> ^ α) ω

OO n oO OO OO OO OO cPoO cO^O MOO cOO rPO rPoO rOoO oOoO oOoO oOoO oOoO oOoO oOoO oOoO oo ro oo oo n oo cη r oo oo oo oo oo oo oo oo oo cn oo r cn oo oo oo oo oo oo oo oo o^ tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

OS OS PS PS PS OS OS X X X X O O O O O O O X X X X z z z z z z co co co co co co co co tf tf tf D D

B a a a a a a H^ HH i-H i^ pS oS p QS pS os pS HH HH^' .-H >A <A >A i-a >-3 X X X X X X X H1 HI H] tfωωωωωωωω

EH EH EH EH EH EH EH O CJ CJ Cj αi Cli Pj Cii &i i C i CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ πl H! H1 tf tf tf CO CJ tf co c Q C ω tf CO CJ Q ω co tf PQ tf PQ CJ CJ O. CJ CJ J o z tf U CJ z o u cj cj o z υ o z CJ O U J CJ z cj o z cj cj υ o CJ cj cj cj cj υ o tf υ ln ^o ω σl O H N π ^ ιn Φ ^ ∞ m o H ( n ^ ιn Φ ^ o Λ O H N π ^ ι ω ^ co cn o rt N n fl ι ω o^ m o H ι to ^ ιn ιo t-■ (lo c!l n (η t^ (η rn ^ 'I ^r ^ ^ ^ 'J ^ ^ ^ ιn l ιn ιn l^l Λ ιΛ ιn ιn ^n ω ω Φ ω ^β ιo Φ lD ιO Φ ^ ^ ^ ^ ^ ^ I~ ^~ t^ co o <!o cD ω o co co oD ω σ^ σ c c c c c c c c cn σ σι σ n c σl c σ <yl σ σ <J σι c σ^ n σι σι σ^ σ σ^ σ σ^

o22oo2o2o22o2o2o2o2o2o2o2o2o2o2o2o2o2oo22o2oo2o22o2o2o2o2oo22o2oo22o tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

H ω H H N Ol ω n ιn N ιn <^l H ^ « ιo co m o ιn (^l ^ (η v « ^ w ^O (o ^ o o <J^| ιn H ^ m ln t^,l ιn v N ιn oo ll ^ H ^ H ^ o ι^, <Jl N ^ (Jl o3 ^ Φ a m ln ^ ro o o l co ( M ^ ^ fll oo H d H N ^ H 05l H (o (Λ N ^n ι H ι ι») o ιcι rl (^l <l' (Λ ( ^^) 0 (^ϊ) ^o o fl (^ «) Ol H ^ (D v o o o oo o o in ^ ^ tΛ ^ w ^ m ij ^ N in ^ H in N ^ oi H rH in ^ c tβ N H in H co σi i'O N O in iD iβ i r- i'i m pl ii Φ H h o o oo ιD Φ co to o o o ol ∞ <D ^ a H (\ (^; ^^ In 'f ιn ^ ^ n ιn ln ιo ^ w ^D ^ ιo ^ ^o ln ^ ^ r- ^ Λ O r^ H ι3l o ol (J\ ^ o o H ι»l t N^, rH iH H iH rH rH CM CM CM i-H rH rH iH rH rH CM CM CM CM CM CM CM N CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ rl rl iH rH rH rH rH rH rH rH iH iH rH iH iH rH iH rH rH iH iH iH rH i-H i-H rH rH rl rl rl i-l rl rl rH rH rl O O -. r .^ . ^ - n ^ "f (η N ι _n. N ^ n^ <J ln w ^ ^ ω m ^ m Φ ln ω I 03 ro σι o H H N ^ H H H C^l ( (^ f^ ^ n ^ 'ϊ^ u^ ^o o ω Φ Cfι

CM CM CM rrHH CCMsl CCNN CCMM CCMM CCMM CCMM CCMM CCMM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CN CN CM CM CN OO OO OO rO OO OO CO OO OO OO M r m o oo J> oo CM en n r- r- en oo oi o cD ^ io io in n tn n ci N N W iB ^ iri iO co ai tD in ij' ^ in n n i v in r m ^ in in iO N rH N H i O H βl 00 00 I- r- H H ri H r~ r^ co r^ r^ r^ r^ r^ r^ r^ r^ r^ r^ r^ r^ r^ r~ r^ r^ r^ r^ r~ ~ r~ r^ r^ r^ r~ r~ r~ r^ r^ r~ r^ r- i— co io io kp io o o o o

oo co oo oo oo oo oo oo cn cn oo cn cn cn cn cn cn o o o o o o o O rH rH CM CM CM CM CM CM CM CM O CO OO C OO OO ^r j< j ^p ID O U) ro r o oo o o o o rθ 'a' «a^{, ,}sr -5j' -si' -a^, >a^, '3' )' Hf Hf « rl rl rl rl ι-H rH rH rH rH rH rH rH rH rH ι-H rH rH ι-H rH rH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

D 3 D D D D w aω ω ω ω ω ω ω ω ω D D D D D D D D O o o O O O O EH EH H EH EH EH EH H pJ oS o p PS S tf tf tf CO CO CO CO w ω Ci ti ω ω u a a a a a a cxi ω ω ω cxi ω c-i tx cs ps os Λ αϊ PS os cxi ω w w txi xi ω w ia w ω ω w HH HH rH M M HH H hi hl iJ J J HI a CM em Dj Ol Ul C- C- ft J ^ H Hl H Hl Hl Hl cι. α4 C-ι α4 i--ι CL θj 2 2 2 2 2 2 2 2 co co co co co co tf tf tf 3 tf 3 tf a a a a

O H N ιη ^ιJ ιn ιfl ^ oo ^ι o H N ⁽η ^ ιn Φ ^ !» ffl O ri N n ^ ln Φ ^ o5 Φ O H csl n ^ ιn ω ^ co ⁽Jl O H t n '^' ιn ^B ^ o^ σι O ri (N n <^

^ ffl ⁽Tl ⁽J> <ϊi m m iJi m m θ O O O O O O O O O H H H H H rl H H H H N (\l N <\| N N W C\l fl C, n iη (1 ( t ( I<) iη f C ^ 'I 'ϊ ^ >» cncncnoocncn oocncnooo ooooooooooooooo ooooooo oooooooooooooooooooooo

H H H H H H H rl H H rl H H H H rl H H H H H H H H H H H H H H H H H H ri H H H H rl H ri H H H oo

2 O oo22o2 ^H EoHo22 Ho2 EHoEHo2 E^Ho2 EHo22 EHo2 EHo2 E o 2 2 H EHo2 EHoHo2 H Eo2o2 2 H EHo2 EHoEHo 2 EHo2 Ho2 HoHo222 222222222222222o22222222222 H E^H EHoEHoHo22 EHoHoEHoHoEHoEHoHoHoEH EoHoH EoHoEHoEHoEH EoH EHoEH EoHoHoEHoEHoHoEHoEHoEHoEHoH o tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

Tάblk l

ATOM 1045 CE1 HIS B 16 102. 207 8. 509 145. 243 1. 00 61. 84

ATOM 1046 NE2 HIS B 16 102. 093 7. 205 145. 061 1. 00 62. 31

ATOM 1047 C HIS B 16 102. 083 10. 901 141. 902 1. 00 48. 11

ATOM 1048 O HIS B 16 103. 177 10. 845 141. 327 1. 00 47. 34

ATOM 1049 N HIS B 16 100. 509 10. 188 140. 098 1. 00 46. 31

ATOM 1050 CA HIS B 16 100. 953 9. ,958 141. 508 1. 00 49. 06

ATOM 1051 N PHE B 17 101. .816 11. ,731 142. ,910 1. 00 47. 00

ATOM 1052 CA PHE B 17 102. ,763 12. ,726 143. ,423 1. ,00 45. ,92

ATOM 1053 CB PHE B 17 102. ,107 13. ,493 144. 587 1. 00 45. 44

ATOM 1054 CG PHE B 17 101. ,954 12. ,679 145. 857 1. ,00 44. ,25

ATOM 1055 CDl PHE B 17 102. 968 12. ,657 146. ,815 1. 00 43. ,19

ATOM 1056 CD2 PHE B 17 100. ,799 11. ,928 146. ,093 1. ,00 42. ,90

ATOM 1057 CE1 PHE B 17 102. ,833 11. ,898 147. ,985 1. ,00 41. ,41

ATOM 1058 CE2 PHE B 17 100. ,657 11. .164 147. ,263 1. .00 40. .06

ATOM 1059 CZ PHE B 17 101. ,670 11. .150 148. ,204 1. .00 40. .32

ATOM 1060 C PHE B 17 104. .133 12. .181 143. ,869 1. ,00 45. .68

ATOM 1061 O PHE B 17 105. .147 12. .890 143. ,818 1. ,00 43. ,64

ATOM 1062 N LYS B 18 104. ,166 10, .927 144. ,307 1. .00 46. .37

ATOM 1063 CA LYS B 18 105. ,415 10, .325 144, .772 1. .00 47. .59

ATOM 1064 CB LYS B 18 105. .142 9, .028 145. .550 1. .00 46. .13

ATOM 1065 C LYS B 18 106. ,421 10. .030 143, .658 1. .00 47. .69

ATOM 1066 O LYS B 18 107. .636 10, .060 143, .895 1. .00 47. .25

ATOM 1067 N ASP B 19 105. ,918 9, .752 142. .453 1. .00 47. ,51

ATOM 1068 CA ASP B 19 106. .774 9, ,416 141. .311 1. .00 46. .25

ATOM 1069 CB ASP B 19 105. .996 8, ,597 140. .278 1. .00 48. .23

ATOM 1070 CG ASP B 19 105. .414 7, .315 140. .862 1. .00 51. .06

ATOM 1071 OD1 ASP B 19 106. .151 6. .591 141. .580 1. ,00 49. .53

ATOM 1072 OD2 ASP B 19 104. .220 7, .034 140. .592 1. .00 50. .69

ATOM 1073 C ASP B 19 107. ,375 10, .622 140. .624 1. .00 44, .83

ATOM 1074 O ASP B 19 106. .895 11. .745 140. .781 1. ,00 47. .81

ATOM 1075 N PRO B 20 108. .439 10. .407 139. .838 1. .00 42. .28

ATOM 1076 CD PRO B 20 109. .144 9. .140 139. .612 1. .00 41, .29

ATOM 1077 CA PRO B 20 109. .106 11, .496 139. .124 1, .00 39, .23

ATOM 1078 CB PRO B 20 110. .348 10, .825 138, .540 1. .00 40, .15

ATOM 1079 CG PRO B 20 110, .550 9 .624 139, .424 1. .00 41, .97

ATOM 1080 C PRO B 20 108, .204 12 .019 138, .037 1, .00 35, .93

ATOM 1081 O PRO B 20 107. .371 11, .291 137. .511 1. .00 35, .62

ATOM 1082 N LYS B 21 108. .381 13, .281 137. .695 1, .00 34, .38

ATOM 1083 CA LYS B 21 107. .581 13, .877 136. .656 1, .00 33, .82

ATOM 1084 CB LYS B 21 106. .633 14, .890 137, .290 1, .00 32, .42

ATOM 1085 CG LYS B 21 105. .802 14, .240 138, .382 1, .00 35, .36

ATOM 1086 CD LYS B 21 104. .698 15 .135 138, .905 1, .00 38 .67

ATOM 1087 CE LYS B 21 103. .854 14 .410 139, .947 1, .00 39 .11

ATOM 1088 NZ LYS B 21 102. .725 15, .254 140, .441 1, .00 39, .48

ATOM 1089 C LYS B 21 108, ,494 14, .501 135, .607 1, .00 33, .46

ATOM 1090 O LYS B 21 109. .656 14 .795 135, .879 1, .00 33, .20

ATOM 1091 N ARG B 22 107. .983 14, .645 134, .392 1, .00 32, .18

ATOM 1092 CA ARG B 22 108. .751 15, .249 133. .318 1 .00 32, .62

ATOM 1093 CB ARG B 22 108. .623 14. .423 132 .021 1 .00 35 .35

ATOM 1094 CG ARG B 22 109. .685 13 .336 131 .798 1 .00 39 .07

ATOM 1095 CD ARG B 22 109. .521 12 .639 130 .429 1 .00 43 .42

ATOM 1096 NE ARG B 22 108. .763 11, .383 130, .484 1. .00 48, .74

ATOM 1097 CZ ARG B 22 109. .266 10, .207 130, .871 1 .00 51, .40

ATOM 1098 NH1 ARG B 22 110. ,541 10, .111 131, .240 1, .00 53, .26

ATOM 1099 NH2 ARG B 22 108. .494 9, .121 130. .895 1, .00 51, .66 Tf l-~ f> JS 00 " O LO O CM ι-H Cθ m θO OO CM O rl OO OO O -3ⁱ O r- rl OO O ^>£> ^ co e ιn Lθ o ιo o r~- o cM co c i c "3ⁱ ι→ !H θ '^q, c o ^l-3 in oo co ιo co oo β 00 00 LO 00 00 o r^ r^ in cn oo co en in m cn ri r D co cr( θ ¹-J in oo cn oo oo cM CM cn ri o © - o oo cM oo o vo co cM in r- ri rt oo ιn ro rH r-- ri oo o u CΛ rl (M H O <Λ O Oi σi rl H rl O H H|i n i') n H N I<) OI OO (O I» ffl » θ n θ O O U IO ιn n H M I») * lfl t~ o c ιo υ3 iθ 'a' m m r~ r- r- oo ^ ιo _OO CO rO cn o OO CM CM C OO OO OO CO r M rO OO OO OO rO CM CM CM CM CM CM OO OO OO OO OO CM CM CM CM OO OO OO OO OO

H U oooooooooooooooooooooσoooooo oooooooooooooooooooooooooo

AH oooooooooooooooooooooooooooo oooooooooooooooooooooooooo rH rl rl rl c-- cn co oo cn cM r-- ri r— oo in co oo o ( H tO 'ϊ H in in tD O ri σi is ifl σi ci f πi i r- h m tΛ in o m H W t H αj W N ciJ M αi i'i ^ o Λ

H H io ^ o αj in v MJi io m oi r o w cM i r n ^ r~ η ι^ σ^ oo o 'a^, iΛ θ ιH io o ι "tf ccn σcni ιιH-H CoDo θo rr~- oo r-- ααoo rr~-- (c^-~ r^- oooθ "srt' CM CMM cΛn oo ccn rH O O OO OO CM rH '3' OO lO CM ιn rH 00 1ⁱ rH i-H in in -=r CM CM CM rl ^l' O OO r~ rH θ c cM θ in <-3 CM r ri r~ oo ri co o cM '=j^, oo >o CM o oo -=r

(η ) l ( M ιn ω ιn H o o ιJ ro ^ Φ ιfi Φ ^ ^ ^ m ol tD ro oo co ^ Φ ^ W Φ ιn Φ ιn ι ι ^ ιn ^ ιn v n ^ (η ^ N (^l N H n ^ <^^, « ^

CO OO OO r CO r rO CO OO OO OO CM C CM CM CM CM CM CM CM CM CM CM CM CM C CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ iH rH iH iH iH i→ i-H iH iH iH rH iH iH iH iH rH rH rH iH i-H iH iH H i-H rH rl iH rl rH iH iH rH iH iH iH ιflm H ow cll cow H H

H ^ ri Φ n oo π ι ^- m oo ^ N o π l» H ^ ^ H oo o N N O ffl t^ H ιn N ι ^ ^ H « ^l' o ιn o) eo 'a' tn H (0 ^■τ o o^ ra (η c^l (^») t (Il ^ι co H (ll O H l/) ^!⁾ (I) ltι M O H ιn o 1 o ol ιn ιn ( O O ( i ⁽!l M ^ o v co ^ ^ 1^| Ol H ιfl 0 0l o nι π (Il H (Λ H O lIno ln ω (D co o ^ o3 (^,ι H co o ιη o ιn t O v ιn m N t ι <τι ( oo n o ⁽η o m oD co ln w r- ^ W Φ ^ W Φ ιn ^ ω ιn o w f O Φ N ^ ω Λ m ^ c^ι o ^ ^ ^ (Il ι oo iO ∞ co αo oo cn r~ co c r^ ι~ tn ιn ^ ^ ^ L ιn ^ Lθ r~ r^ co co cD co ιn ^ oo c ri o σ^ o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o cn o o o o o o o o o o o o o o o o o o o ri

H rl H H H H H H H H H H H H H H ri H ri ri ri H ri H ri H ri H H H H ri ri H i-H rl rl rl rl rl rl rH rH rl rH rH rH i-H rl rH rH rl rl rH

⁽Ni c π ri ro fo r f i^ t ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ i i i in io in Φ iO Φ Φ UJ iD io Φ D r^ r^ ^ . ^ r^ ∞ oo oo oo iri m σi σi o o

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM co cQ oa pQ PQ αa Q rø a Q Q pa αi cQ cα ffl o oQ m cQ m co ffl m ffi cQ o ω m ffl ffi

CJ CJ D D D D EJ D D D OS OS OS PS OS OS OS PS OS PS PS OS CO CO CO CO CO CO CO co co co co co co co co Z X X X X X X X ω W cή cd cxi xi ti ω ω w cx xi X X X X X X X X X X X X X X X X X X X X X X X X X X X c zo c zo c zo z co c zo z co z co O πa < πa πa Ha π πa a a ^ Hl J ia Hl H Hl Hl Hl EH EH EH EH EΠ EH EH EH EH EH EH EH O O U O O HA j Hi ni H Hi ia Hi ^K rt; tf tf tf tf tf tf c c cj c c cj c cj αi Oi rl CM rl rl CM CM rl CM tf CO CJ Q Q tf cα cj α ω α cxi co a tf pQ cj tf co c Q ia co o o z υ o u cj υ o o tf CQ CJ ^Q Q tf tf tf c cj o cj cj cj cj cj o υ o υ υ co υ o z υ o υ υ u z υ 2 U U U 0 Z U 0 2 U U 0 Z U U 0 Z U

Tf r- fl <N in oo oo m r- ^r in o cM ^ -y M i r -o o cM in r- ^o o oo ro m r- M cn rH co ri cτι o o ri co ri co ri cM in ι o oo r-- 'q^, '5i^, n r- co r--

© "tf 00 rl CO CM rl 00 «a' θι o o oo co m m co σι ιn ri ri oo m r- m T Co oo cri in c CϋHO Ul O CO lO O tΛ in σHiUD O σi M Λ ri ^ OO O ri © CΛ rl rl CM CM cn r^ co in ^ in o n i ro o c M ^ ^ C c i i io rn 'tf fO ti ri i-H oo oo co o oo o f- 00 00 O oo n tn m n n p n n n r oo ci ' ^ 'tf n c n n n r fo ro cn oo r oo n r r oo cM CN CM oo oo oo oo oo oo cM CM Oo oo oo ^r

H U OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

AH OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOO

(O Λ lB o ιη ^ O H π ιJl ^ O (B ω {o αJ l o (ι o n Φ ^ H Φ ^ σl H Φ ιn ^ ιn Φ O H 'l^| ιn ιn ffl H ιn co ι^,l o>l ln 'lⁱ ^^ (^ n o ^ ^D H (^l ¹ ιn ι !Λ m ιo ^ σl H ^ ι < 0₃ ^ ( ^ ^ l o co o ιD H Ol ^o r- σι H o n ^ x <^ α) ^ o m ι^,^ ^ (D ^ n ι<l (η M co o H ιn (lo ^^ o ιn ol oo 'ϊ co m o n <_J ln (X) ^ Φ O ln ω ιn ln oo o ιn ω ^ H ^ H to H O ^!J ^n σι IJl ln Φ H ^l H co H ^ ι ιn ω Φ ^ ^o <» co ^ '^^ι ^D ^ to (! (Jι <J lC)

CM eM oo c ^ CM oo θ rH cn c t^ ι^ ι^ i£> ιn ιn ιn uo c o θ ri ιH o cM cn co cn co ∞ r^ r~ ∞

{M N N C>l (M lM N « ( H H H H H H H H H H H N N ( N ( N H H H H H H H ri H H H ri fl H H H H H H H H H H H H H H H rl

^ i r~- c <£i o r-. c cM in c cD C m ri o M oo cM ιH ro ιn ∞ oo c CM ^ vo oo c r~ ^ ι→ ri ι M ^ N θθ r~ o o oo ιJ3 r-- oo in 'τ ^t' c rH n Ln r~-

( o xn ^ H ro oo in in iD rt o ω αnfl f t r^ c in cM o cn ao in c oo o ^ ^ o in o >^ o ^i' "a' cn r~- CM O oo o o '3^, r- o cn Oo co r_^ oo o oo o cM in _'^' i-D -a' r M M i-H i o r~ o o r~ ^ ιH oo o «3 r-- o ^ ιH o o o -=i' < ) CM M M r-- oo ^|J3 θ -a' r '* r~ ^l ι o θ H '<3' o

CM CM CM OO CM ^r CO O O rl O σi O OO OO OO CM OO CM OO CM C ^■sjⁱ 'a' in vo r-- oo cn σι o o o r- oo oo σι co < ι r~- r~- o θ rH CM oo oo cM θθ CM CM i-H rH rH rl rH rl rl rH rl rl rl O rH O O O rl rl rl — ^■ — ^■ — ^■ — ^I — ^I — ' — ' rl CM CM CM rl rl rl rH i-l rH rH rH CM CM CM CM CM CM CM CM CM CM 1-l rH rH ι-H ι-H rH ι-H ι-H rH rl rl i-H rl rl rl rl rl H ri d ri H ri H H H ri d ri H H ri H H ri H H H H

o o o o o o o o o H H H H H H H H H H H i N N N t N N ts i'i t'i t'O t'i o tn n ro m i'i rO 'j Hj ^ ^ ^ fli ^ ^i in in in i/i in in in ir) oo r oo oo co co oo o co n co oo n oo oo po c^ n oo oo oo oo oo co ro oo po oo po po co co m m m PQ PQ m oa pQ pa ω Q m cQ Q PQ CQ PQ PQ ω ω c ω m ω ω a m pQ pq Q cQ Q PQ ffl t axl Cxl Cxl Cxl Cxl Cxl Cxl tx ω ω Cxl td Cxl Cxl Cxl Cxi ω U Cxi ω D D D D D D D D O CJ CJ ϋ ω ω cx cxi txi s oS oS os oS pS oS S pS i-a H H H .. _H H πa H

04 a Qj D a a a a a a a a a a a a a a a a a a cxi w j cxi os o H H H αj ^ft αj dj Oi αj αj ttj iii αj αjαi αjfcc CM j HiHiJ taj j Ha tf tf tf tf tf tf tf tf tf tf tf rl rl rl rl l rl CM rl CM rl CM rl CM CM rl l-H CM rl rl CM co cj Q Q ω ω co Q Cxi Cxi O D α Cx CO a a tf CQ CJ CJ Q tf PQ CJ Q Q Cxi ω cj cj cj c cj cj cj cj tf CO CD Q tf CO CD Q Q tf O C z CJ J J CJ υ J υ u o o z υ o CJ υ CJ J o z o u J J z J z z CJ O Z CJ CJ CJ CJ CJ CJ O Z U O O CJ Z CJ Z

o22 HoH

TάBle 1

ATOM 1210 C HIS B 35 123. 436 17. 302 134. 848 1. 00 39. 62

ATOM 1211 O HIS B 35 123. 449 18. 093 135. 796 1. 00 38. 77

ATOM 1212 N PRO B 36 124. 045 16. 104 134. 912 1. 00 39. 09

ATOM 1213 CD PRO B 36 123. 867 14. 947 134. 014 1. 00 39. 98

ATOM 1214 CA PRO B 36 124. 769 15. 698 136. 117 1. 00 38. 70

ATOM 1215 CB PRO B 36 125. 303 14. 324 135. 746 1. 00 37. 90

ATOM 1216 CG PRO B 36 124. 187 13. 773 134. 938 1. 00 38. 98

ATOM 1217 C PRO B 36 125. 870 16. 673 136. 521 1. 00 38. 41

ATOM 1218 O PRO B 36 126. 284 16. 687 137. 678 1. 00 37. 55

ATOM 1219 N ASP B 37 126. 327 17. 494 135. 575 1. 00 38. 67

ATOM 1220 CA ASP B 37 127. 367 18. 476 135. 866 1. ,00 39. 47

ATOM 1221 CB ASP B 37 128. 194 18. 804 134. 620 1. ,00 41. 64

ATOM 1222 CG ASP B 37 127. ,404 19. ,576 133. 574 1. ,00 44. 39

ATOM 1223 OD1 ASP B 37 126. 465 20. .313 133. 950 1. ,00 44. 40

ATOM 1224 OD2 ASP B 37 127. ,734 19. .458 132. ,370 1. ,00 45. 65

ATOM 1225 C ASP B 37 126. ,796 19. ,783 136. ,409 1. .00 40. ,37

ATOM 1226 0 ASP B 37 127. .542 20, ,745 136. ,601 1. .00 41. .14

ATOM 1227 N GLY B 38 125. ,482 19. .836 136. ,629 1. .00 40. ,30

ATOM 1228 CA GLY B 38 124, .875 21. .055 137. ,152 1. .00 38. ,99

ATOM 1229 C GLY B 38 124. .299 22. .029 136. .125 1, ,00 38. .03

ATOM 1230 O GLY B 38 123. .657 23. .009 136. .501 1, .00 36. .64

ATOM 1231 N ARG B 39 124. .525 21. ,787 134, .837 1. .00 37. .93

ATOM 1232 CA ARG B 39 123. .969 22. ,666 133, ,809 1. .00 39. .37

ATOM 1233 CB ARG B 39 124. .578 22. .392 132, ,436 1. .00 42. ,00

ATOM 1234 CG ARG B 39 126. .018 22, .802 132. .223 1, .00 46. ,71

ATOM 1235 CD ARG B 39 126, ,459 22. .370 130. .817 1. .00 51. ,06

ATOM 1236 NE ARG B 39 126, .320 20. .921 130. .634 1. .00 54. .86

ATOM 1237 CZ ARG B 39 125, .992 20. .323 129. ,487 1. .00 56, .96

ATOM 1238 NH1 ARG B 39 125, ,893 18. .996 129. .436 1. .00 57. .35

ATOM 1239 NH2 ARG B 39 125, .751 21. .044 128. .395 1. .00 56. .77

ATOM 1240 C ARG B 39 122. .470 22. .413 133. .680 1. .00 39. .42

ATOM 1241 O ARG B 39 121, .997 21 .295 133, .899 1, .00 38. .02

ATOM 1242 N VAL B 40 121, .733 23, .452 133. .298 1, .00 40. .07

ATOM 1243 CA VAL B 40 120, .284 23, .353 133. .107 1 .00 40. .65

ATOM 1244 CB VAL B 40 119, .526 24, .162 134, .182 1 .00 41. .39

ATOM 1245 CGI VAL B 40 118, .045 24 .203 133 .862 1 .00 41. .97

ATOM 1246 CG2 VAL B 40 119, .738 23 .525 135, .545 1 .00 42. .94

ATOM 1247 C VAL B 40 119, .876 23 .848 131 .713 1 .00 40. .44

ATOM 1248 O VAL B 40 120, .300 24 .921 131 .274 1 .00 41, .16

ATOM 1249 N ASP B 41 119 .056 23 .064 131 .018 1 .00 39, .94

ATOM 1250 CA ASP B 41 118 .607 23 .430 129 .669 1 .00 39, .12

ATOM 1251 CB ASP B 41 119 .706 23 .118 128 .659 1 .00 39, .83

ATOM 1252 CG ASP B 41 119 .986 21 .622 128 .554 1 .00 43, .38

ATOM 1253 OD1 ASP B 41 120, .942 21 .243 127 .844 1 .00 45, .53

ATOM 1254 OD2 ASP B 41 119, .251 20 .820 129 .180 1 .00 42, .00

ATOM 1255 C ASP B 41 117, .365 22 .622 129 .312 1 .00 37, .83

ATOM 1256 O ASP B 41 116 .745 22 .011 130 .184 1 .00 38, .38

ATOM 1257 N GLY B 42 117 .021 22 .603 128 .028 1 .00 35, .97

ATOM 1258 CA GLY B 42 115 .860 21 .849 127 .590 1 .00 35, .38

ATOM 1259 C GLY B 42 116 .124 20 .881 126 .446 1 .00 35 .25

ATOM 1260 O GLY B 42 117 .119 21 .001 125 .742 1 .00 37 .44

ATOM 1261 N VAL B 43 115 .233 19 .912 126 .268 1 .00 33 .57

ATOM 1262 CA VAL B 43 115 .352 18 .928 125 .203 1 .00 32, .47

ATOM 1263 CB VAL B 43 116 .279 17 .752 125 .573 1 .00 30 .78

ATOM 1264 CGI VAL B 43 117 .687 18 .146 125 .372 1 .00 30, .16 oo oO i o cn ri '3^, 'tf θ oo oo oo ooo ooo oo c o LO oo ri O '^i' O cn t co ri CM "tf CO 00 CM ∞ oo ^ cM i H CM CM oo cn o co co ^ σi ∞ iH iH ^ oo oo in i ri oo i O 'tf co c 'tf n n

O 00 rH i-H r- i-H V 00 *£> C0 rl CM 00 I-~ CM CM O 00 "j M in o o5 m w c) (ii in i») r- H O ⁽ H⁾ (D OS M <i (j> ri o r r-- c coo oi cn (\ . <n ifl o ^ o O CO OO "-3 rH t"- CO PO I-- uO r~ '<tf PO " 0 "tf i-H CM 00 i-H CO r~ r~ r- n ι r- M θ σι ιn ~ r-- n H n 'tf yι m ^|-D θ i cM r- oo so r— so r- oo o in so

<ι^, ιn ( rη H H o m oo ω ∞ n n m n tη fn N H N ^ ιn "j ιn ι ω ω ^ » w ^ ιn ω ιn <i' ^ ι-- ιo ^ ^ oo iιι m m m oo o o m H ⁽<) H <

CM CM CM CM CM CM CM iH iH iH rH CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ oo υJ o σi i-H o in rO "tf *O i "tf r- αo c cn vo io Cn θ rl O CM tn r- p- o io r- Λi σi io io r~ ^o o c iH f^ r^ r~ o ^ iH ^ c c c r^ ^ r~ o c oo cM o M o r-- M r-- >£i M M c i i o in -stf r~ ^jι vo oo "tf i ij ai N N in H N m m u3 σ^ ri r r-~ ιH cn oo cn oo o co ιH co co oo oo ^o oo oo ιn ri oo ^r oo o o "tf C ro o cM cn o r- rH en r- I-H o en CM CM r- oo

O cn cM P~ "tf CM CM O H θ H|^, m ιn lO (!1 0 (J1 0 H H 01 0i n i51 0 1fl C H O O CO H ⁽Jl H (JI O IΛ ιn CO ^ M W 00 rl l in ri o r- CM CM oo cn r-- ιj3 io cM CM oo oo m in m co vo r- oo oo vo in r^ oo co cn o oo r- oo oo

^ ιη n "f "f "f "^ ^ « "r "^ ^ "f ^ ιn ιn ιn ιn ιn ιn ιn Λ ι Φ W lB lo w Φ Φ Φ ^ ^ ι^ ^ ^ o ω ∞ co ω ω oo ω ι cl ⁽J\ Λ ⁽Jl lJ^ σl O o

^J* *ϊ3* *^* ^* ^3* ^3* ^* ^* ^* ^J¹ ^3* *3* ^* ^¹ ^^ "'_^J' ^* ^^ ^J* ^J¹ ^^ ^T ^* ^ * ^P ^ϊ* ^* ^3* ^3* ^J¹ "*3* ^J¹ ^J¹ ^T ^f¹ ^* _*J* ^J* ^F ^J* ^J¹ ^J¹ ^J^ *T ^T ^J* ^J* *^ϊ* "^ "^ ^ϊ* ^* ^* LO L ^Q oa m m m m 3 PQ PQ m p3 PQ pa Q PQ pa Q pQ oa m Q Q pa oa pQ ω m pQ θ3 ω pa pa Q ffl PQ m pQ ffl ι-a ι-i cj cj cj c c c cj cj o cj cj D D D D D D D CO CO CO C C C^ C-i PS pS PS C-I Oj C-i CLi αi C-i CLi Cli C-i St_fOStfOStfPStfDS ptfStfoStfciStfCiS HI H! H) π t-a πa ι-a X X X X X X X td txi cxi Cxi ω w co co co co co co co co o o o o o o o

> tf >tf tfpStfpStfp PS S OS OS PS PS PS H M

CJ CJ CJ CJ CJ CJ CJ CJ CJ π π π _H Ha H H Ha o co o co tf tf tf tf tf tf tf tf ciι c-ι c-. θj iι (ij Cij a a cj tf pQ c α ω co a a tf CO CJ Q Cx ω tf oa cj α x co tf α cj tf co u Q Q Q tf CO CJ f

CJ CJ O Z CJ CJ CJ CJ Z CJ Z Z CJ O CJ CJ O CJ O O CJ O Z o υ ou o z υ o z cj cj o υ o z ou u o o o o z o c cj CJ υ o t

CJ H ^ f^ ^ ιn w ^ co σι r^ H H H H H H H ri rl rl rl rl rl rl rl 22 22 2222 o o o o o o o o tf tf tf tf tf tf tf tf

Table !

ATOM 1320 CB HIS B 50 119. 514 14. 516 132. 433 1. 00 38. 33

ATOM 1321 CG HIS B 50 120. 771 13. 732 132. 248 1. 00 39. 99

ATOM 1322 CD2 HIS B 50 121. 628 13. 656 131. 205 1. 00 40. 25

ATOM 1323 ND1 HIS B 50 121. 224 12. 830 133. 186 1. 00 40. 36

ATOM 1324 CE1 HIS B 50 122. 304 12. ,228 132. 725 1. 00 41. 16

ATOM 1325 NE2 HIS B 50 122. 569 12. ,711 131. 525 1. 00 41. 80

ATOM 1326 C HIS B 50 117. 064 14. ,529 132. 695 1. 00 33. 22

ATOM 1327 0 HIS B 50 117. 154 15. ,649 133. 191 1. 00 32. 87

ATOM 1328 N ILE B 51 115. 921 14. ,046 132. 237 1. ,00 31. 67

ATOM 1329 CA ILE B 51 114. 726 14. ,867 132. 302 1. ,00 29. 82

ATOM 1330 CB ILE B 51 113. 988 14. ,899 130. 938 1. ,00 27. 56

ATOM 1331 CG2 ILE B 51 114. 947 15. ,389 129. 861 1. ,00 27. 80

ATOM 1332 CGI ILE B 51 113. ,427 13. .520 130. 591 1. ,00 23. 56

ATOM 1333 CDl ILE B 51 112. 630 13. .498 129. 324 1. ,00 19. 14

ATOM 1334 C ILE B 51 113. 744 14. .454 133. 387 1. ,00 29. 57

ATOM 1335 O ILE B 51 112. ,771 15. ,156 133. ,625 1. ,00 29. 45

ATOM 1336 N LYS B 52 113. .998 13. ,324 134. ,043 1. ,00 30. ,99

ATOM 1337 CA LYS B 52 113. .119 12. ,857 135. ,114 1. ,00 32. ,77

ATOM 1338 CB LYS B 52 113. .319 11, ,364 135. ,377 1. .00 35. ,63

ATOM 1339 CG LYS B 52 112. .769 10. .497 134. .265 1. .00 40. .57

ATOM 1340 CD LYS B 52 112. .534 9. .059 134. .718 1. .00 43. .44

ATOM 1341 CE LYS B 52 111. ,798 8. .274 133, .625 1. .00 44. .57

ATOM 1342 NZ LYS B 52 111. .173 7. .015 134. .138 1. .00 46, .19

ATOM 1343 C LYS B 52 113. .387 13. .651 136. .386 1, .00 31, ,74

ATOM 1344 O LYS B 52 114. .458 13. .540 136. .990 1, ,00 30. ,75

ATOM 1345 N LEU B 53 112. .389 14. .443 136. .776 1. ,00 30. ,81

ATOM 1346 CA LEU B 53 112. ,450 15. .321 137, .941 1. ,00 28. ,75

ATOM 1347 CB LEU B 53 111. .893 16. .689 137, ,561 1. .00 26, ,09

ATOM 1348 CG LEU B 53 112. ,283 17. .154 136. .159 1. .00 23. .54

ATOM 1349 CDl LEU B 53 111. ,568 18. .436 135. .788 1. ,00 21. ,62

ATOM 1350 CD2 LEU B 53 113. ,780 17, .343 136. .124 1. .00 22, .95

ATOM 1351 C LEU B 53 111. .656 14 .791 139, .123 1, .00 28, .90

ATOM 1352 O LEU B 53 110. .652 14 .108 138. .960 1. .00 29. .34

ATOM 1353 N GLN B 54 112. ,116 15, .114 140, .323 1, .00 29. .74

ATOM 1354 CA GLN B 54 111. ,426 14, .695 141, .530 1, .00 28, .75

ATOM 1355 CB GLN B 54 112. .362 13 .864 142 .403 1 .00 26, .78

ATOM 1356 CG GLN B 54 111. .667 13 .080 143, .490 1 .00 28. .67

ATOM 1357 CD GLN B 54 110. .638 12 .088 142, .956 1, .00 30. .79

ATOM 1358 OE1 GLN B 54 110. .960 11 .197 142, .163 1, .00 33, .61

ATOM 1359 NE2 GLN B 54 109, .396 12 .235 143 .398 1 .00 30, .23

ATOM 1360 C GLN B 54 111. .025 15 .986 142 .234 1 .00 28, .64

ATOM 1361 O GLN B 54 111. .854 16 .671 142 .816 1 .00 29, .72

ATOM 1362 N LEU B 55 109. .752 16 .340 142, .132 1 .00 28, .94

ATOM 1363 CA LEU B 55 109, .270 17 .554 142 .759 1 .00 27, .80

ATOM 1364 CB LEU B 55 108, .072 18 .148 142 .006 1 .00 27, .78

ATOM 1365 CG LEU B 55 108, .160 18 .507 140, .514 1 .00 26. .52

ATOM 1366 CDl LEU B 55 109, .194 19 .576 140 .274 1 .00 27, .66

ATOM 1367 CD2 LEU B 55 108, .480 17 .267 139 .724 1 .00 27 .39

ATOM 1368 C LEU B 55 108, .863 17 .173 144 .167 1 .00 27 .87

ATOM 1369 O LEU B 55 108, .118 16 .210 144 .389 1 .00 27 .58

ATOM 1370 N GLN B 56 109 .394 17 .925 145 .119 1 .00 27 .07

ATOM 1371 CA GLN B 56 109, .115 17 .699 146 .519 1 .00 26 .11

ATOM 1372 CB GLN B 56 110, .390 17 .269 147 .244 1 .00 25 .15

ATOM 1373 CG GLN B 56 110, .220 17 .014 148 .719 1 .00 20 .80

ATOM 1374 CD GLN B 56 109, .326 15 .828 149 .010 1 .00 23 .03 f> S

© ιo σ> r- CM en "tf ^T r co _^r «tf co o cn m oo cn oo oo iTi cM oo cn co in o oo •q' 'tf oo cM CM oo r~ cn oo o oo r- 'tf in cM ^,Λ cM o r- o ιn oo ri cM r- oo © oo θ oo •q" r- Γ~ t— "tf CM CM cn o r- ri oo rH CM O OO r^ rl »tf <Tl 'tf O P~ rl CM ιH ^ cM ∞ ιn σ> oo cn oo cM in r uo oo r-- r-- oo cM ^,q^, ro co r-- CM 'tf cn ri

CΛ is δ ri "tf r_^ co r- r^ r- oo o o ri M CM in r- ^r cM C ^i' r- H o C ri θ ri cM ri ιo '<tf ^tf -q' ^«tf θ θ σι oo ^{, )} ιn r ri oo oo CM CN rl OO rl O OO m

C_M CM C_M CM CM CM CM CM CM n o O OO O O "tf "tf ^' C C C0 0 r rθ 0 -=l' "tf -^ "tf r 0 CM CM CM CM CM CM rl rH CM CM CM CM CM CM rH CM

H υ OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

AH OOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOO rl rl rl rl rl rl rl rl rl

^ ^ ιD H ro » o ( ( H n (Λ m Φ n H m ri N H^ ^ o m ^ ^ ^ ^^ Φ o ι (η r^ r- <J^ c(! ^ ^ (D ι ^o ^ ■I O Λ co ω 1 (^ι o <Iι ri O f^ o ω σι ^ o w ω H ^ ^ ιn ^ σι ^ m rι (η ^ o Λ ^ π H ^ι o ιJι ιn o c^ W (n ω ω o H σ C ^ ln ι ιn H l ^,iι n^ 'J ω ^ Ol r_' ι l ^^ o ^£ι ^ O Λ o m o tD l^,ι ι^,) ιn (Il o o ^ (Jl "» "f l^rl <Jl t ^o o ιJι rl Φ ^D O N tD co 'l¹ r^ (J O 'l^, (^ι ι ^ ιn () ^ H (') O ι3l v o o ffι ^ o tD (Il Cft

^ ιo co o ω o o o Λ H H n n H O H N ( N M ^ ιn ^ ^ oo M tn ^ ^ ^ (n ^ ιn ιn Φ ω ιn ^o ■» ι ιn ^O ln ιn lC ιn ^ ■τ ( n N M ri N c^ m in ri

CO UJ O m rj iO en oo oo cn r- co m r- r^ oo oo cn o rH r^ r- io m in io o co io ^r ^•stf C CM O Cn oO r- CO CO VO CM CM CM CM 'tf 'tf 'tf <£> r- co <£> r— <θ [~ oo r- '£> co o o o o o o o o o o o o o ^{■ ■} o o o o o o o o o o o o o o σi σ^ σ^ cn cn cn o o o o o o o O O O O O O O O O O O rH

ω o N (') n oo n (') (η L i m m m cα m ra m m m pα pQ m Q pα cQ m pQ cQ m m z z z z 3 tf α n D n π D D D D D D Ω D D SO D D D CJ CJ CJ CJ CJ Cj α CJ CJ CJ CJ X X X X Ha ha πa Hi .-a πa π π π H H Ha H Ha H H H H Ha H H Ha ps os ps s ps oS o PS p S Ha Ha Ha H tf tf tf tf tf tf tf tf tf tf tf tf tf

CJ J J CJ tf tf 3 tf 3 tf 3 tf CJ J CJ CJ CJ O CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ (j α tf tf tf tf tf tf tf tf tf tf tf UI CJ CJ CD > >

CM rl CM CM rl CM

Cx] Cxi tf PQ tf co c Q w ω tf co c Q w ω tf co cj α cxi co a a tf tf co CD CD tf CQ CJ CJ

O z υ o z CJ CJ CJ o CJ υ u c o o o o z υ o cj cj o o υ o O O CJ O Z CJ Z Z cj o z u CJ o z J J CJ CJ CJ o z CJ CJ CJ CJ CJ ιn co ι^ oo c o ιH (N θ "tf i D r-- co c o rH CM ^ ιn ^,o r~ oo n θ ri cM 'tf in o r-- oo o o > ι 3 r- oo σι o ri c o "tf i ϊ r- oo c r- t^ r- r- r- oo oo oo oo oo oo oo oo oo oo oo cri cn cn cn cn cn cn cn cn o o o o o o o o o O rH co c oo co oo oo co co oo ro oo r c c r cn co c c oo oo oo oo oo oθ "tf ^ ^ ^ "tf "tf "tf "tf "tf "tf 'i'

o 2 2 22 22 22 22 2 2 O O O O O O O O O O O O O tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

TάbTel

ATOM 1430 O VAL B 63 110. 484 24. 060 145. 071 1. 00 28. 04

ATOM 1431 N SER B 64 110. 842 21. 894 145. 577 1. ,00 26. 96

ATOM 1432 CA SER B 64 112. 253 21. 905 145. 214 1. 00 27. 58

ATOM 1433 CB SER B 64 113. 153 21. 333 146. 323 1. 00 26. 89

ATOM 1434 OG SER B 64 113. 006 19. ,927 146. 434 1. ,00 27. 20

ATOM 1435 C SER B 64 112. 197 20. ,941 144. 048 1. ,00 27. 27

ATOM 1436 O SER B 64 111. 467 19. 956 144. 090 1. 00 27. 77

ATOM 1437 N ILE B 65 112. 943 21. ,239 143. 000 1. ,00 27. 86

ATOM 1438 CA ILE B 65 112. ,954 20. ,399 141. 820 1. ,00 26. 92

ATOM 1439 CB ILE B 65 112. ,755 21. ,274 140. 552 1. ,00 26. 65

ATOM 1440 CG2 ILE B 65 112. .860 20. ,409 139. ,280 1. .00 26. ,91

ATOM 1441 CGI ILE B 65 111. 390 21. ,982 140. 646 1. .00 24. 20

ATOM 1442 CDl ILE B 65 111. ,158 23. ,103 139. 653 1. .00 21. ,27

ATOM 1443 C ILE B 65 114. ,284 19. ,663 141. ,781 1, .00 27. ,92

ATOM 1444 O ILE B 65 115. .338 20. .279 141. ,604 1. .00 29. ,68

ATOM 1445 N LYS B 66 114. .235 18. .349 141. ,975 1, .00 27. ,70

ATOM 1446 CA LYS B 66 115. ,443 17. ,536 141. ,974 1, ,00 27. ,93

ATOM 1447 CB LYS B 66 115, ,433 16, .571 143. ,141 1, .00 28. .47

ATOM 1448 CG LYS B 66 116. .602 15. .613 143. ,107 1, .00 28. ,99

ATOM 1449 CD LYS B 66 116. .637 14. .760 144. ,353 1. .00 31. ,91

ATOM 1450 CE LYS B 66 118. ,065 14. .652 144. ,880 1, .00 34. ,91

ATOM 1451 NZ LYS B 66 118. .119 13. .913 146. ,175 1. .00 37. ,70

ATOM 1452 C LYS B 66 115. .621 16. .709 140. .717 1. .00 29. ,46

ATOM 1453 O LYS B 66 114. .724 15. .950 140. .354 1. .00 29. ,47

ATOM 1454 N GLY B 67 116. .777 16. .847 140, .064 1, .00 29. .55

ATOM 1455 CA GLY B 67 117, .058 16. .059 138. ,877 1. .00 29. .40

ATOM 1456 C GLY B 67 117, ,436 14, ,674 139. ,374 1. .00 30. .54

ATOM 1457 O GLY B 67 118, ,471 14, ,506 140, .019 1, .00 31. .69

ATOM 1458 N VAL B 68 116, .600 13. .680 139, ,097 1, .00 30, .20

ATOM 1459 CA VAL B 68 116, .861 12. .328 139, ,577 1 .00 31. .28

ATOM 1460 CB VAL B 68 115. .708 11. ,363 139. ,188 1, .00 29. .45

ATOM 1461 CGI VAL B 68 116. .075 9. .937 139, ,551 1, .00 24. .11

ATOM 1462 CG2 VAL B 68 114. .424 11. .768 139. .911 1 .00 26. .34

ATOM 1463 C VAL B 68 118. .184 11, .744 139. .110 1 .00 33. .38

ATOM 1464 O VAL B 68 118. .915 11 .157 139, .899 1 .00 33, .82

ATOM 1465 N SER B 69 118. .494 11, .893 137. .830 1, .00 36. .86

ATOM 1466 CA SER B 69 119. .744 11, .352 137, .317 1 .00 38, .82

ATOM 1467 CB SER B 69 119, .751 11 .387 135, .792 1 .00 40, .75

ATOM 1468 OG SER B 69 120, .967 10 .861 135, .293 1 .00 42, .57

ATOM 1469 C SER B 69 120, .941 12. .137 137. .867 1, .00 39. .71

ATOM 1470 O SER B 69 121, .865 11, .550 138. .434 1, .00 40. .03

ATOM 1471 N ALA B 70 120 .911 13 .459 137, .717 1 .00 39, .07

ATOM 1472 CA ALA B 70 121 .998 14 .316 138, .187 1 .00 38, .97

ATOM 1473 CB ALA B 70 121 .841 15 .714 137, .608 1 .00 37, .82

ATOM 1474 C ALA B 70 122, .102 14 .422 139, .702 1 .00 39, .68

ATOM 1475 O ALA B 70 123, .134 14 .840 140, .231 1 .00 40, .63

ATOM 1476 N ASN B 71 121 .041 14 .044 140, .401 1 .00 40, .19

ATOM 1477 CA ASN B 71 121 .007 14 .161 141, .854 1 .00 40, .46

ATOM 1478 CB ASN B 71 121 .953 13 .170 142 .516 1 .00 40 .79

ATOM 1479 CG ASN B 71 121 .742 13 .090 144, .016 1 .00 40, .60

ATOM 1480 OD1 ASN B 71 120 .735 12 .562 144, .486 1 .00 41, .57

ATOM 1481 ND2 ASN B 71 122 .683 13 .630 144 .775 1 .00 41, .54

ATOM 1482 C ASN B 71 121, .398 15 .584 142 .270 1 .00 40, .88

ATOM 1483 O ASN B 71 122 .240 15 .780 143 .154 1 .00 41, .28

ATOM 1484 N ARG B 72 120. .788 16 .567 141. .611 1 .00 40, .64 co m oo o r- oo in cM CM c c o io ro cM O oo m N 'J' (^,l ιo o H oooooooo oooooooo rl OO lXJ LO rl CO OO -tf CO O O 'q' OO VO CO OO itf O H αι o ti! r- N (Ji θMn o ι») (D r~ o O H I») (\H£l ιn <f O C0 r-I I^») H r- O T rl O^ ri m O r^ cn en oo ri ri cM ri in 'q' in m oo ro in rH ri cM oo r-- oθ "tf ^r ιn r-- ri i-D oo oo cn cM CM cn oo oo cn oo uj o tn oo ri ∞ r— r- m ιn cM θ ri cn oo co r-- cM ri L oo ιθ 'tf r-- m σι σι ri n m ^o m o cM ri oo co ^ι r~ >o M in r~ c cθ rH M m ιn o θ ro r m i-H in σi rH cn o o en oo o ri o O r- rl rl rl O Cn oo r^ OO rH CM O rl CM O Cn O O O 00 00 rl CM O rl O O rl CM 00 rl O rl CM CM

"tf "tf 00 00 "tf "tf "tf "tf i' 'tf "tf ^,,tf 'tf r co oo oθ "tf ^i' ^)^, "tf ^f '^' "T "3> «τ O n "» ^r ^i ^i ^i ^i ^* ^* ^P ^J^ ^ζji ^* ^r ri ri ri H H H ri ri ri H H H H H H H rl

O O Ul in i' H ^ ^ lD ffl ri m θ ι-H "tf i co co ιo r~- M θ co oo "tf r-- ko r- o _'^' r- ι cn 'tf ^o oo oo oo cn o r- ri in i-H σi in co r- m o r^ 'tf m co o oo ι-H θo ^r cn o ri r~ "tf CM "r Φ n o tn o σno ^ N σi oo ω H H i iη in ^ o ^ m in ri cn M r- oo i iO ri o σi 'sj' o m oo r ri oO ji 'tf c i-D ri r- in o M rH r^ N oo D o co ri O 'tf o in '^f oo ^o o M C in o 'tf LO '-D ^r r- ' i ri c o cM cn ro m o ri cM oo io co cM -<tf i-H CM ri m cn oo o

^ co (!o o^ (o ffl o m ω co (5l O H O^ m co m α) ^ ^O ri l N t^,l (^ '» f fl' ■J ^ ιn ^D ^o ^ ^ <!l o o (^ι t (D r^ H ri (^^ N H O H O ^ 'il' <^^ι ω ^

H H H H H H r H H ri H CVI N H H H H H H H (\| N N N ( ( C\| N C\| N N ( ( N W N (O fl n cn tn n n n n n rD n m fn n n n n π

CM σ σ> ιo ^ ι oo c o og o c» o oo ι→ cn ^ rH ^ ιH CM ιH ιH oo r^ o r~ σ^ o o O ^O CMM ι rHH o0o0 r rHl rrii rr--- <o^ σcnι ^'^r ιioo co»o ιinn ccMM OO O Ln cM CM 00 co en IO CM r- m H O O N r- icno io <j> m N H "r m cD ifl H M n N O ^ ⁽o n ^no oi H ⁽O O in ^ r~ oo r r-- o ooo r r~-- cooo Hri fr noo (cjni cooo oo w^lo ιn oo >J3 'tf Cθ o co n o * cj oo iD t^ i^ ω ^ N H N H Oi oo σi ω ^ ^ ^ M o oo Λ ^' iD iβ t iD in ^ Φ oo r^ Pl iD ^' co r -_- r -^ Φ ,« i ,o„ w_ ^_ i.n_ '_ϊ i .n_ ■ _ri oo in ι ι

H H M ij ifHo m r- σ> oo en ω ιI) w m w ^D r- ^ oo l ^ ^ ^cι m ι£ι <^' ^o m o (Jl oo o3 ^ ^£⁾ ^fl ι (D oo αι m o H ( N n ιη o m o o H

H H H ri H ri H H H rl H H H ri H H rt H H H H H H H H H rl H H H H H M N N t M N N H I IM M rl rl rl rl rl rl rl rl rl rl rH rl rl rl rH rl rl rl rl rl rH rl i-H rl rl rH rl

CM CM CM CM CM CM CM CM CM CM 0 0 0 0 0 O0 0 0 0 0 0 0 "r v ^ Hr ^ ^ⁱ ^ⁱ ^r in in in iΛ m iD iD m Φ ω io iB i^ t^ t^ r^ p- r- r^ ^ r- o ω co i~ r~ ^ r~ r~ r~ r~ r~ r^ r~ ~ r^ r^ r^ r~ r- r~ r^ r^ r~ r^ r~ r~ [^ ^ r~ r-- r-- r~ r~ m m m ω ω co ω ω m m pQ ω pQ m m m ω ω ω cQ m m m ω Q m m pQ m rø oS aS QS oS oS oS eS pS tf tf tf i-ι E^H E^H E^H E^H E^H E^H E^H CO CO CO CO CO CO CO CO CO D D D H >H H >H X X X χ [ Dιl |D_qD , Cι5 tDJ tD35 [Dl [D£l [D₁q _ltf_a >- πa i-i w ci cxi cd tx cxi cxi xi x x x x x x x i-a H H Eπ EH FH H H EH h FH H Hl Hl Hl Hl Hl Ht a Hl l* tf .tf tf 2 22 S S 2 22 ι a Hj H H a Hi H] J o u ϋ rl rl CM CM tf co c Q cxi to a a tf CQ CJ Q Cxl Q H CO a tf PQ CJ Q Q tf o tf CO CJ Q ω tf CO CJ Q Cxi CO tf O

CJ CJ CJ U Z O Z Z CJ O υ υ υ υ o cj υ cj o u o u u u u u υ o J o o o z cj u u co c o o z υ υ u cj cj z α o z o υ

2oo22o2o2oo2 2 22222 2 222 22 H E^Ho2 EHo 2 EHo2 EHo22 EHoEH Eo 2 Ho2 EH Eo2 H EoHoEHoHoEH EoHoEHo2 EHo2 EHo2 EHo2 EHoEHo2 EHo2 EHo2 2 EHo2 EHoo2 H EHoEHoEHoEHo2 HoHoEHo222222222222222222

E^H EH EH &H E EHoEH EoH EoHoEH EoHoH EoHoEHoEH EoH EoHoEHoEHoEHoEH EoH EoH o tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

ιo 00 CM H CM C m oo io ooo ooo w oo oo w ^ ^ o ω o ^ ^ H Φ ^ ιn ^ ιn m o m ιη H ^ H ιn ^o (n Φ m r^ "l' <Jl r• (η (ι oo ^ ιn <J^ O l ( l (^ι tι3 Λ H ^ "J co o tD ^ ιn (η σl n ^ (ι ιn (Λ H m n ι H H o ω H c^ι H Φ ιn co ^D ^1 H H α ^ Φ ω c^ Φ o α; ιn N M π (Λ ln (o ιn ro ^ ^ ^ ln co ^ ^ N ^ ιn ιD ι o r~ u3 i/) co i^ r^ in r~ ^ co r~ ^ i cO "tf in co co i co Ln r^ co co co in r~ ^ o i c

N N n c^ι o o (Il ω ^ ^ Φ lD > ω ιn Φ ι ιn Φ Φ oo ω σι ^o ^ ιo ^o ιn ι <J N ^fl ιn ^ ^ w o σι ω Λ co σι ω o o H n "I ι (^,l ^ ■^ ^ τr ^ ^ co <η r o o oo ro r o co ro r o r <^ o (^ o o oo o ro o r D c ro o co M i-H iH i-H iH iH rH rH i-H rH rH i-H iH rl i-H iH iH iH i-H i-H iH iH iH iH rH iH tH lH iH rH iH rH iH rH i-H rl rl i^ f rH r~ n c ^tf r- ri 'sr cM r~ m θ '^ r~ ^| ι r- "tf θ ^i' ri oo iD ri c oo cM ^ r~ o c in 3θ ^ ι cΛ ^ ι^ c co ro r~ oo c ^p o r-- -«tf θ "tf co (rι c c '£> io cM r- co cn r- in oo ^o cn oo o oo <£> i— e in ^o cM oo in "tf o ω "tf CM rH co r^ r~- oo r i' <£> ιn oo ^r ιn o ιn ^, C in c r-~ r~- '>' r-- o oo r-- M "tf "tf CM θ c o n r~- ^r "tf θ cri rH r- vo σ^ co ^■tf 00 CM CO 00 U3 "tf ■H CM co cTi oo oo in oo co oo oo 3 r~ r~ r^ ^tf CM oo cn r~- o ^,x> in cM ro r~ oo io in c cM

^ co m ^ ^ Φ ^ ^ Φ ιn ^n Φ ^ ln "f ιη ^ (η (^ι ^l N N ^ι n "I « o o ol m ^ o3 ^ co ^ ^ Φ ln Φ ^ w ^ '!f ιn ( l H l H (^l (^l (D π ri ro c co co n co c^ ro r ro c ro i m ro oo oo c n oo n oo oo n oo oo oo oo oo cM CM CM CM CM CM CM CM CM c^ r ιn oo cM cn ιn cM vo cn ιn ιn r~ ^, ι cθ "tf θ co m co co m θ Ln oo m o co oo ιn >o ιθ rH o ι r- o M r- ιn c r >o ιo τ c co 3ⁱ m <M ^o c ι 'C CM H ^ rO i-H 3 c iO rH rH rH O rH o -=j^, M r~- in ¹ > c co -5i' r- oo M «tf ri r~ ^o r r~ r- r- ^p o o co o ri M O r^ oo ri co r- cn in ^ cM oo in r- co -o ιn ri c "tf θ σι ro oo σi ι-ι σi co oo co c-- o cn «tf tτι r-- cM θ θ oθ cθ ι-H θ oo ιn '<tf ( ^ c- e r- r- H N O iO N N n v ri o in ri o v H H cM co r in o cn iH o cM CM ro cM cn cn cn oo oo oo cn o rH CM 'tf in in 'tf in o o cn cn co i^ co

CO OO OO OO OO OD Cn cn OO Cn cn Cn cn cn O O O O iH iH H iH rH rH rH i→ iH rl rH CM CM CM CM CM CM CM CM n O CO m oO OO OO OO p ^ ^ ^ ιn ι ιn ιn m

^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ω ∞ » ∞ (B oo » ω oo o ∞ (c oo o oo tD Oo co oo o oo ω co co o tD ω ω oD ω ω 000000 0000 0000 00 00 O CO CO CO CO O m m m m m ω ca a m m m m cΩ ca m a m ω m m m ω m ω ca ai ai ca ca ai ca m Da cQ CQ CQ CQ CQ CQ cQ PQ CO CQ CO CO CQ QQ PQ

D D D Oi Oi C-i Cii C c ai Oj D D

CO CO CO CO CO CO CO CO ttf tf tf ςxi cxi tf tf tf tf PS OS OS OS OS π co ω ω ed ω

CJ J J CJ CJ CJ tf tf tf tf f ii a tf tf co co co co co u a ω ω tf co cj a a tf CO tf ω cj J CJ O O J o z cj c υ o o u o o o z u υ υ o z υ υ o u

O H N M "J ιn w ^ ⁽I⁾ σl O H Cv n ^ ln ^D α) σι o H N I^»l ^ ιn ιfl ^■ oo tΛ O H (N ^^ ^ ιn ^β ^ co m o H ( (η "J• ιn ιo ^ oo m o rl ^^ (^,^ ^ "f v ^ ^ ^ Hr ^ ^ ij ^ iΛ in in in in in i i in tn Φ Φ ^ Φ Φ Φ Φ Φ Φ r^ i^ h r^ ^ r^ ^ i^ r^ t^ co oD aϊ ω os oo co oo ∞ oD ^ Λ σ^ m o in in in in in tn in in in in in in in in in in in in in in in in in in in in in in in in in in in in uo in in in in in in in ^ iH rl iH iH iH rl iH i-H iH rH rH iH iH iH iH rl rl iH iH rl iH rH iH rl iH rH iH rH iH rl iH rl iH iH iH rl iH

o22o 2o2oo22o2oo22o2oo22o2oo2o2o22o tf tf tf tf tf

O

m CO rOπO CM CO <£> "tf ^«tf O CD m r- θ oo vjⁱ -tf yi oo o σi t- σi oo cθ "tf < θ o θ i c 'q' C ri oo ro co co ro co r ro ro oo co o o ooooooooooooooooooooooooooooooooooooooooooooooooo o o ooooooooooooooooooooooooooooooooooooooooooooooooo

O H ιn ιrι a o n ι o^ o ^ 9 n o o '» ιn H v H O v o ^ ιn N ( ffl co (ι m H (J (η N ^ ω M ιJι w ^ N ^D ^ t^ι n o o o ω ^B '^' (o o <» H ^ cι m n ^ Φ O Φ O O ln H H J o^ oo ^ Φ (D N ιn Φ ι ιc ιn ^ Λ oo ιn H ^o ιn ^c) ^|-l ( αJ H ι '* ιn o ^fl ^ m H ιn oD O ^ Ol o (η H Φ O ^ n ffl "f m o ^ O N C O ^^ ^ o Φ ω o1 ln ω () ιη ^ i o ιη o ι^ ^ Φ Λ cn o n N 1 m ^ι m H ^ σl N o σl 'ϊ m tη ω (D Λ ^ι oo i' -tf m 'l' f O H o o ι]l Ol co ^ ω u) lIl os o o o H H N H l H ( O f ^o ^ ln ^o ^ ιn ^o ιcl ^ o^ (Il o o ( ιJl IIl ω IΛ (^ι O rl O (^ι tD co ^£> tf) ^ ^ ιn 5I^, ^() ^()

-

( ιn o^ m Φ ^ N o ιn ω n lJl ^ H σι π ^ H m o ιc ιn u^ cI^ ι^ι ω ^o ^ ^ H «) ω "J t O t-^■ ^ ^l O ι H (J ιn l ιn c^) n^ cD ^l "^ ^ •!P U^ (!l (!^ ^ (^ι ω H m (Jl ω ^ ιn Hp (n ^ H o m ^o ^ ιn ιn π Hl' N H ^ ^ ιn ιo n ιo o ^ n ^l "f ^ ι^^ o 3 eo ^ ιΛ r^ H ^ ^ H ^^ (') rl (o m pι c^ι ιn o ιn ⁽D M ^l ^o o ιo ιB ^ ιn ω o ^ ^ ιn ^ O H ^ ra H H ^ N ^ ^ r- ιn ρ• ^■ ^ o σl ^ (») ^β m ιn ^ ^c co ιn Φ H W lfl ^D H Ol ^

CM 'tf 'tf vo vD co r- r- c oo oo cM oo -tf rH CM O cn oo r^ CO O O OO O rl O M 00 r-~ r~ r^ co e oo r~ ιn r~ r-- oo σι θ ri o M^j co co cD i-3 oo "tf "tf cM

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rl rl rl rl CM CM rl CM CM CM CM rH rl

ιn co >o ιo ιo ιo co ιo <-^j ιo r~ r^ r-- r^ r^ r~ oo oo oo oo co co co cn cn cn cn σ> cn cn o o o o o o o θ ri ri rl rl rl rH rl rl rl CM CM CM CM CM CM OO OO oo oo oo oo oD oo oo oo oo oo oo oo oo co oD co co co co oo oo co co oo oo oo oo oo oo co cn cn cn cn cn cn cn cn cn cn cn cn en cn cn cn cn cn cn cn cn cn cn cn cn

PQ ω ω ω ω ω ffl ω m m oa pQ cQ m m m m m ω o Q ω pQ m ω m ffl ω oS co co co co co co co co c pS pS cS oS oS oS i-a π πa D D D D D D D D D CO CO CO CO CO CO Cxl Cx]

X X X X X X X X X w t cj ω H j tf a a a a co co co co co co co co Hi J H π πa x x x x x l-a rl ► π co co co co ω co > £tf a a a EH -H EH Eπ tf tf tf tf tf tf tf tf rl CM rl CM rl CM tf O CJ tf CO J CJ z O CD Q Cxi ω tf CQ CJ CJ υ cj cj cj Z CJ tf CO CD α Q o z c υ o cj Z CJ CJ CJ CJ o tf C o z CJ cj o υ υ o z J J CJ o o CJ o z J u CJ J O o tf

CJ o z CJ CJ O CJ O Z J in ^o r- co cn o rH CM oo ^ ιo co r^ oo c o ιH M "tf i o r~ co c o ιH M θ '^H in co r~ oo oo o ιH cCM ooOo ''tf iinn vvoo rr~-- oooo cc oo rrHH C coO 'q' in co r^ oo ri cn cn cri cn cn o o o o o o o o o o r-. r-. _π in m in i m Φ io ω Φ Φ ω Φ Vfl iD φ ic Φ Φ

00 22o2o2oo22o2o2o2oo22oo22o2o2o 2 O o 22oo22o o 2o2oo2o2oo22o2o2o2o2o2o2o2o2oo22oo22o2oo2o2o22o o tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

Table !

ATOM 1650 CB PHE B 93 112. .182 26. .819 147. ,659 1. 00 31. 02

ATOM 1651 CG PHE B 93 112. .813 25. .853 148. ,604 1. ,00 31. 34

ATOM 1652 CDl PHE B 93 112. .373 24. .532 148. ,660 1. ,00 32. 18

ATOM 1653 CD2 PHE B 93 113. .882 26. .235 149. .401 1. ,00 30. ,66

ATOM 1654 CE1 PHE B 93 112. ,996 23. .606 149. ,502 1. .00 29. 81

ATOM 1655 CE2 PHE B 93 114. .508 25. ,318 150. ,242 1. ,00 29. ,19

ATOM 1656 CZ PHE B 93 114. ,061 24, .001 150. .289 1. ,00 29. ,42

ATOM 1657 C PHE B 93 111. .692 27. .409 145. .266 1. .00 31. .34

ATOM 1658 O PHE B 93 112. .080 28. ,542 144. ,967 1. ,00 31. ,56

ATOM 1659 N PHE B 94 110. .564 26, .886 144. ,798 1. ,00 29. ,36

ATOM 1660 CA PHE B 94 109. .731 27. .621 143. .860 1. .00 26. .56

ATOM 1661 CB PHE B 94 109. ,992 27. ,093 142. .452 1. ,00 25. ,63

ATOM 1662 CG PHE B 94 111. ,426 27. .126 142. ,071 1, ,00 24. ,51

ATOM 1663 CDl PHE B 94 112. .004 28. .299 141. ,607 1. .00 25. ,06

ATOM 1664 CD2 PHE B 94 112. .220 26. .000 142. .243 1, .00 25. .56

ATOM 1665 CE1 PHE B 94 113. ,356 28. .356 141. ,321 1, ,00 25. ,77

ATOM 1666 CE2 PHE B 94 113. ,574 26. .039 141. ,962 1, .00 25. .63

ATOM 1667 CZ PHE B 94 114. .148 27. .219 141. .499 1, .00 25. .73

ATOM 1668 C PHE B 94 108. .255 27. .503 144. .175 1, .00 25, ,19

ATOM 1669 O PHE B 94 107. .820 26. .531 144. ,803 1. .00 23. .94

ATOM 1670 N PHE B 95 107. .493 28. .502 143. ,742 1, .00 22. .53

ATOM 1671 CA PHE B 95 106. .055 28, .485 143, .944 1, .00 23, .75

ATOM 1672 CB PHE B 95 105, .469 29, .894 143, .954 1. .00 21, .99

ATOM 1673 CG PHE B 95 105. ,775 30. .663 145. .196 1. .00 22, ,80

ATOM 1674 CDl PHE B 95 106. ,414 31. .901 145. .120 1. .00 22, ,56

ATOM 1675 CD2 PHE B 95 105. .441 30. .144 146, .448 1, .00 21, .37

ATOM 1676 CE1 PHE B 95 106, .723 32. .608 146, .274 1. .00 24, .07

ATOM 1677 CE2 PHE B 95 105. ,743 30. .836 147, .610 1. .00 20. .75

ATOM 1678 CZ PHE B 95 106. .386 32, .072 147. .530 1. .00 23. .23

ATOM 1679 C PHE B 95 105. .425 27. .707 142. .804 1. .00 25. .56

ATOM 1680 0 PHE B 95 105, .349 28. .188 141, .670 1, .00 27, .02

ATOM 1681 N GLU B 96 104. .991 26. .489 143. .089 1, .00 26. .35

ATOM 1682 CA GLU B 96 104. .359 25. .706 142, .056 1, .00 27. .18

ATOM 1683 CB GLU B 96 ^' 104. ,443 24. .212 142, .361 1 .00 26. .72

ATOM 1684 CG GLU B 96 103. .867 23. .337 141, .254 1 .00 26, .24

ATOM 1685 CD GLU B 96 103. .691 21. .901 141. .685 1, .00 28. .35

ATOM 1686 OE1 GLU B 96 103, ,162 21. .678 142, .795 1, .00 30. .76

ATOM 1687 OE2 GLU B 96 104. .064 20. .988 140, .920 1 .00 31. .23

ATOM 1688 C GLU B 96 102. .909 26. .158 142, .020 1 .00 28, .96

ATOM 1689 O GLU B 96 102. .167 26. .018 142. .993 1, .00 31, .23

ATOM 1690 N ARG B 97 102, .509 26. .726 140, .897 1, .00 29, .93

ATOM 1691 CA ARG B 97 101. .148 27. .187 140, .751 1 .00 2 .36

ATOM 1692 CB ARG B 97 101. ,105 28. .718 140. .754 1, .00 32, .52

ATOM 1693 CG ARG B 97 99. .740 29. .288 140. .426 1, .00 35, .07

ATOM 1694 CD ARG B 97 99. .770 30, .797 140, .343 1 .00 41 .18

ATOM 1695 NE ARG B 97 98, .453 31. .329 139, .994 1 .00 47, .09

ATOM 1696 CZ ARG B 97 97. .402 31. .326 140, .812 1, .00 48, .95

ATOM 1697 NH1 ARG B 97 97. .520 30, .823 142, .036 1 .00 50 .33

ATOM 1698 NH2 ARG B 97 96. ,231 31. .812 140, .405 1 .00 48, .08

ATOM 1699 C ARG B 97 100, ,526 26. .663 139, .471 1 .00 27, .73

ATOM 1700 O ARG B 97 101. .104 26. .783 138, .392 1 .00 26, .45

ATOM 1701 N LEU B 98 99. .350 26. .059 139, .611 1 .00 27, .65

ATOM 1702 CA LEU B 98 98. .585 25, .555 138, .473 1 .00 27, .40

ATOM 1703 CB LEU B 98 97. .707 24. .376 138, .909 1 .00 23, .68

ATOM 1704 CG LEU B 98 96. 669 23. .882 137, .894 1, .00 21. .58 Tf r- ιc <^ι H co ir ιη σι m n » ^ Λ ιn <_\l H ιn co H ω ^ (x) O Φ ιη o Φ ιn H ^ w σι o o ιn ^ ^o ω o H 9 ιn ln co (^,) N <Λ c() H H co r^■ (») ^ α) js is 0^ ^ ₀3 n Φ ffl (D o ω ^ 03 N ^ (Il Φ N σ_l ^ι al o ^ Λ ln H (!l Φ ^ ω Φ Φ ( H ^ Φ H ^ Φ cD O ln ^ ^ ( l H O ^ cl (^l ^D f CJ σι r• ^

© o δ o o ^ w o_J ω (I_l tD H o n ιJι co w o ra « N ^ N O Ol eo w (I (^ι H ω ιn ιn ^ ^ W "J a φ (o ι^ rt ^ O ( N >o ^■ ^¹ ( ι t N ^ (Il H co

CΛ (M CM CM CM CM CM CM CM OO OO OO CM C CM OO CM CM ΓO I^ C OO CM CM CM CM CM OO CM CM CM CM C CM CM CM CM CM CM CM oooooo _ o_ o_ o_ o_ o_ 000000000000000000 oooooooooooooooooooooooooo ooooooooooooooooooo o o o o o ooooooooooooooooooooo oooooooooo υ φ _fl O H O -i' tri N N Oi ω o σi n σi uj m co ^ tn rn ^ w n oo m o N O o Φ ^ r' iΛ N - O iH O N H ω ^ o m iD O ri oo oo in o ^p en so oo "_l' (I_l ^ "_l' σι 'ϊ H ( σl H ιn ι» C) N O l co ιn o o H O O ln (M ^ H ( eJnl ^ r~ M oo N CM ^ r- ^ n H co ^o u^ ιn o^ H N t ι » ffl r^ r— CM so en i— in so ιn -sτ σι ιn cn co oo cn oθ "tf co oo cD 'tf cn cn o ιn o oo ιn r- ^)' ^,-3 r-- ιn ιn r- ¹ m r -- .¹o- -r- «tf 0^ o —o r -~ oo c .o ιn ιn_ cM. r- "tf ri oo Lθ c— co o o so m "tf w co ^ (» ω ^ ι _ll^ Φ Φ ιn ιn ιn "_J "_f ^ n M N H O H (^ι o H o ^ι n N ^ n H N (^l (ι l H O Λ co (Jl oo ^ Φ "J ^ "l^, ιn w ^ r■ r- ιn ^ oo oo oo oD oo oo oo oD co ro ro oo oo oo oo oo oo oo oo oo oo m eo oo oo ro oo oo oo ro c ro oo oo oo oo oo oo o^

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H rl H H H H H H H H H H H H rl H H H H H H H H H ri H H ιn co n σι N σι Φ » H m n σ m Φ ^ ^ r- ι ^ (J ^ ι H Φ o n oD O ι Φ (η ^ι cΛ c^l ^ ^ ID ^ n ^ Φ ιn N '!^ o ιD ri O O ^ (') co ^ ι n ^ o ^ H H (^ι <_I Φ ^ a co N ω m N Φ N ^ (Jι oo » n o N <I) _l)o m m o3 H Λ ^ Λ H ^ H O "f ιn o ol ^^ co (D (Jl ω f^ ^ <Jl oo (J ιn ιn ^ θ >if in ι ω ro ri ^ N o w H <_f n ιn o ιn (Ji ω w ( o v ra ιJi i(i w oo ifl n H θ H θ (rι ιn ιn o o w j) H (<) ri ^ o o3 Λ H (D H N cM ^ r~ r~ o c c o ιH ιH co ρ~ c cn o rH Cθ oo o t~ n oo oo cn co ιn ιn ^ ro oo co ^ 'tf ro ιn ιn ιn Ln "tf "tf ^

CM CM CM CM CM CM CM CM OO OO OO CM CM CM CM OO OO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ s

O < r000 "tf rH ιtf CM 00 in θ r~- l£> rl C0 'H 00 r- m θ Ln θ C0 rH -tf CM O rH

^■q' l -tf oo co o e i m n oo 'tf O i' oo ri oo in r^ oo c c '^r fo r- O 'tf r- θ ri r~ oo cn <tf oo co r- o c θ cn cM θ cn r~- oo r~ ^r ri r~- oo cD oo cM r~ r~ ιn c^ ^ co r^ co cn cn o co ιo ιn ιn "tf oθ "tf CM in ιn ^ r^ c^ oo ιn ιn ιn ^ ιn oo co cM r-- c~ oo cn o θ rH θ cn cn cn cn o Cn rl CM CM rl O CM CO OO

Λ Λ W Λ CΛ Oi Λ Λ ffi o m m m σi σi σi m σi m σi σi m w σi m σi σi w iJi cΛ tJi oi m m σi σi m o o o o m m ai σi o eno o oo oo o o

co eo ω αi m m ^ m m Λ m m m o o o o o o H H H H H H H H M N N N N N N N n in n n n i'o n n iη i'o n rO 'i' Hf fl Hi' Hf ^ iai ^ en σ> αι σϊ cn cn cn cn cn σ σv σ> σ> o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o iH rH rH rl rl iH rH iH iH rH iH rH iH iH rH rl iH iH iH iH iH i→ rl iH iH iH i→ iH rH i-H iH iH iH rH rl rl rl rl rl rl rl H ω ω ω cQ o co co cQ ω m pQ m ω m ω oa m PQ m pQ PQ P^ m pQ m m o pQ pa m oa Q m

D D D D D D D D D D Q ID D OS OS OS OS OS OS Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z OS CS OS PS OS OS PS PS PS PS PS

Cxi Cxi C^χl Cχl r -l ,-a- •-a- r-l ■-a- π- π- πa- π _ Cx] C^.xi C^.xi C_x] _ Cx] ω^. Z co co CO co O CO O O CO co CO O CO co CΛ co X X X X X X X X X X X x X tOo e COn t coo tOo e COn eOn

H-l H-l H-l CJ CJ CJ J CJ J CJ CJ CJ O O CO CO CO O tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf rH CM rl CM rl CM rl CM rl CM CM rl CM

U tf CO CJ u Cxi Cx tf Q CD tf cα CD Q Q tf PQ CD Q Q tf CQ CJ Q Cxi Q w CO a tf ro CD Q Q

U J CJ υ ss u u CJ CJ o o J o z J CJ o CJ o z CJ υ J o z υ o z υ CJ J o z u o z J υ J υ J u υ υ o o o z J υ o o Z CJ O oo o ιn ιn ιn H H H

o22oo2o22o2oo2o22o2oo22o2o2o2o2o2o2o2o2oo2o2o22o2oo22oo22o2oo22o2o2o2o2oo2o22o2oo22oo22o2o2o2oo2 tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

Table !

ATOM 1760 N THR B 105 103. .505 26. 856 136. 620 1. 00 23. 55

ATOM 1761 CA THR B 105 104. .555 27. 862 136. 580 1. 00 25. 40

ATOM 1762 CB THR B 105 103. .987 29. 298 136. 497 1. 00 23. 35

ATOM 1763 OG1 THR B 105 103. .069 29. ,521 137. 576 1. 00 24. 27

ATOM 1764 CG2 THR B 105 103. .293 29. ,509 135. 178 1. .00 19. 24

ATOM 1765 C THR B 105 105. .380 27, ,713 137. 851 1. ,00 26. 45

ATOM 1766 O THR B 105 104. .847 27. .446 138. ,924 1. ,00 27. ,70

ATOM 1767 N TYR B 106 106. .685 27. ,882 137. 727 1. 00 27. 80

ATOM 1768 CA TYR B 106 107. ,554 27. ,755 138. 881 1. ,00 28. 15

ATOM 1769 CB TYR B 106 108. ,503 26. .592 138. 646 1. ,00 24. ,96

ATOM 1770 CG TYR B 106 107. .735 25. .288 138. ,599 1. ,00 23. ,60

ATOM 1771 CDl TYR B 106 107, ,488 24. .566 139. ,769 1. ,00 21. ,27

ATOM 1772 CE1 TYR B 106 106. .742 23. .395 139. ,750 1. ,00 21. ,89

ATOM 1773 CD2 TYR B 106 107. .208 24. .800 137. ,394 1. .00 21. .41

ATOM 1774 CE2 TYR B 106 106. ,456 23. .626 137. ,360 1. ,00 21. ,03

ATOM 1775 CZ TYR B 106 106. ,229 22. .925 138. ,548 1. .00 24. ,06

ATOM 1776 OH TYR B 106 105, ,515 21. .741 138. ,546 1. .00 23. .62

ATOM 1777 C TYR B 106 108. .280 29. .061 139. ,145 1. .00 30. .41

ATOM 1778 O TYR B 106 109. .245 29. .426 138. .469 1. .00 31. .45

ATOM 1779 N ARG B 107 107. .780 29. .768 140. .149 1, .00 31. .96

ATOM 1780 CA ARG B 107 108, .312 31. .061 140. .535 1, .00 32. .79

ATOM 1781 CB ARG B 107 107. .152 31. .979 140. .912 1, ,00 32. ,00

ATOM 1782 CG ARG B 107 107. .533 33. .406 141. .148 1, ,00 33. .23

ATOM 1783 CD ARG B 107 106, .334 34. .300 140. .910 1, .00 35. .90

ATOM 1784 NE ARG B 107 105. .191 33. .986 141. .771 1, .00 40. .00

ATOM 1785 CZ ARG B 107 105. .077 34. .354 143, ,045 1, .00 39. .85

ATOM 1786 NH1 ARG B 107 106. .034 35, .054 143, .638 1, .00 38. ,97

ATOM 1787 NH2 ARG B 107 103. .996 34. .019 143. .729 1. .00 41, .38

ATOM 1788 C ARG B 107 109. .274 30, .938 141. .696 1, .00 33. .01

ATOM 1789 O ARG B 107 108. .957 30. .282 142. .690 1, .00 32. .53

ATOM 1790 N SER B 108 110. .441 31. .571 141. .558 1, .00 34, .47

ATOM 1791 CA SER B 108 111. .481 31. .557 142. .595 1, .00 36, .46

ATOM 1792 CB SER B 108 112. .690 32, .402 142, .178 1 .00 37, .32

ATOM 1793 OG SER B 108 113, .657 32, .459 143, .215 1 .00 36 .67

ATOM 1794 C SER B 108 110, .947 32 .111 143, .898 1 .00 36 .91

ATOM 1795 O SER B 108 110, .438 33, .233 143, .932 1 .00 37 .00

ATOM 1796 N ARG B 109 111. .059 31. .335 144, .970 1, .00 37, .99

ATOM 1797 CA ARG B 109 110. .564 31, .808 146, .249 1 .00 40, .27

ATOM 1798 CB ARG B 109 110. .465 30, .672 147, .263 1 .00 40, .19

ATOM 1799 CG ARG B 109 109. .690 31, .068 148, .511 1 .00 41 .08

ATOM 1800 CD ARG B 109 109. .061 29, .853 149. .173 1 .00 42, .63

ATOM 1801 NE ARG B 109 110, .060 28 .944 149 .723 1 .00 44 .24

ATOM 1802 CZ ARG B 109 110, .484 28 .960 150 .984 1 .00 45 .28

ATOM 1803 NH1 ARG B 109 109. .993 29, .843 151, .848 1 .00 46, .59

ATOM 1804 NH2 ARG B 109 111. .402 28, .084 151, .379 1 .00 45, .30

ATOM 1805 C ARG B 109 111. .485 32 .895 146 .769 1 .00 42, .63

ATOM 1806 O ARG B 109 111. .067 33, .741 147 .570 1 .00 43 .11

ATOM 1807 N LYS B 110 112, .736 32 .890 146 .308 1 .00 43 .86

ATOM 1808 CA LYS B 110 113, .673 33 .913 146 .748 1 .00 44 .94

ATOM 1809 CB LYS B 110 115, .098 33 .364 146 .858 1 .00 46 .17

ATOM 1810 CG LYS B 110 116. .062 34, .455 147 .292 1 .00 47 .98

ATOM 1811 CD LYS B 110 117. .294 33 .939 147, .986 1 .00 50 .45

ATOM 1812 CE LYS B 110 117. .932 35, .064 148 .805 1 .00 51 .51

ATOM 1813 NZ LYS B 110 119. .185 34 .665 149, .515 1 .00 52 .68

ATOM 1814 C LYS B 110 113. .666 35 .166 145 .865 1 .00 45 .12 m r vo o O oo c en co co o D oo ro o oo vo io cM in co cn rH i-i o in m oo o ^r cn o o in m rH cyi oo ri ro r- o σi ri cD o cyi Ln cn m o o p- in ri r- i o r- ri oo r~ '«tf r cTi ^ in "tf OO '^ r- "tf oo cM ri oo cD "tf ri M o σι ^< o ι r-- ιθ "tf "tf oo oo Ln M M r~ ri "tf r-- o ιn c c r r- rH i r~ rH -» co oo in ^o m cM oo m cM cn n cM O co en r- oo cM O i' rH co co cM LO rH θ cM n ri cM t^ ιo oo oo o o c~- co ι-H ri cn r^ oo r ri "tf r~- ri σ> co o cM ro <JD CM 3 -tf 00 CM 00 00 r T in oo rH oo ^ in co M CM o o o σ> oo cn oo oo co co 3 σ^ r~ oo oo σι σ co σ^ <Λ io ιn co co co ιo r-- vD r-- co ιn 'θ ιn υD

^ * ^F ^J* ^ ^ * ^3^ ^5ji ^3* ^1 ^* ^* ^* ^T ^^ *3 ^* ^* ^3* ^4* τtf «tf "tf oo c oo oo ro oo r oo oo oo oo oo ro oo co oo r ro ro co oo ro oo oo co oo ro oo oo ro oo oo N (D ιn ol ω o fl ω ^ ^ l ri H o m ^ ( ^ ^ ιn ffi ^^ O H O ^ o o oJ ^rι ^ (Jl ^ '» 030 σl ιn ol O (I) C O ( (^ι ιn (^r) ^ ^o ιn o p^ > ^ (^ι (\| ι_J O^ ιn o ι ω Φ H ^ m o (ι ι N ( ω o ^ o ^ ul Φ ^^ Φ W ιn N ω (J ffi "l^, ι^ co ω o (J ιn ^ Φ ^ ιn cΛ '» ^ ι rl (D ιn t^ι m H N ^ H m ^ ω in ^ (η H θ (η fθ θ ( H r- <r ιn o ιn oi fi tD N in <o o m r- ιθ H N ^ N iθ H ^ ι H θ oo N (Ji fi σι ( H N m o ϊι ι ) ^ ιo ιn u ιo ^ ^ ^ uo ιn co ι^ ιo o r~ oo u) co ιo r^ co o cn r^ r^ ^ ιn L r~ r~ oo ^ oo cn c r-- oo "tf c co ro c oo oo oo oo co co co ro r oo oo ro (^ M oi oo oo oo oo oo oo ro co ro (O r oo oo ro oo oo c co c^ ro (n

^ m o i m iO "f i ^ ^ ^ ^ N <» » H "t o n ^ oi (o in io vi N O M H n ^ ^ H H H ( O N CN H H m i oi i ^ N r N i3i H <fl (ji (ji ri ι ι N m >» ^ v (Jι m ιn N H Λ ^ n ( ^ ^ n o n Φ ^ σι H^ N ^ ^ι « o ra ^ι ^^ (n ω ^ r- co o N W n ^ W ln ^ι <ι σι O lJl ω w ^o (l H ^ ιn ιn ln Λ ιn ^ ιn ^ n ιn H ω H ^ o cD H O o3 ^ι n Φ ω w ιn H Φ ^ι v ιo ι Φ 'ϊ ^ ^o ^ ^ ι ^n H ro ^o ^O ln ιn ^ ^ (^| H (3l o α oo oo oo oo ^r ιn co r^ co r~ oo cn cM ri ri cn oo oo co oo co oo oo cn o cn cn o M ι^ι 'q' in cM o ι co D θ o o o oo r- r~ ⁽o co m m "tf

O O O O O O O O O rl O O i-H rH rl rl rl rl rl rH rl rl rl rl rl rl rl O O O O O O O O rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl i-l rl rl rl ,

θ H H H H H H H H H H H H N N N N N N N n rπ n po (θ (D "» ^p <> ^ 9 ^ ^ 'i^, 'j^, ^ ^ ^ ^ "i ιn ιn ιn ι ιn ιn ιn ι ι ιn ιn ι ω ifl io rH ιH rH ιH ιH ιH ιH ιH ιH ιH ιH ιH rl rl ιH rl rH ιH rH rH ιH rl ιH ιH rH ιH ιH ιH rH ιH ι-H rl ιH ιH ιH r^ rH rH iM rl iH rH rH rH rl rH iH iH iH iH rH iH rH rl iH iH rH rl iH lH lH rH iH iH iH rH H iH lH lH lH i pQ Q o ffl cQ Q PQ oa p Q o cQ co ω cQ co m Q cQ CQ ω ω m m m m cQ ω m m m pQ cQ Q PQ CQ m i-H rl CM CM rl CM CM CM OO rH rl CM CO CM rl rl CM CM tf PQ CJ ^Q Cxl Q Cxl CO a tf PQ CJ CJ tf PQ CJ tf pQ CJ Q Cxl Cxl Q bl tsl lSi a tf P C

ZUUUUUUUU0U02UU0UU O Z cj cj o υ o z J CJ CJ CJ CJ CJ CJ Z CJ O U U o z uuQuJ ^QuCuxl QuuCxlυCOoauozu tfuo ι w o!ι <n i-H iH CO OO

H rl H rt

00 22oo22oo2o22oo22o2o2o2o2oo22oo22o2o2o2o2o2o2o2oo2o22oo2o2o22oo22oo22o2o2o22222222 22222 o o 2o o H EH EH EH EH EH EH EH H EH H H H H EH EH EH H H H H H EH H EH EH H H H EH H H H EH H EH H EHoEHoHoHoHoHoEHoHo 222 H oHoEHoHo2 HoHoEHoEHoHoEH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

n (n so o o rl rl rl rl rl rl rl ^ Φ σ^ oo H N H iB H ιn r^ ^ ^ m H H θ θ (Λ oo co oi > σi W iβ ιn ^ ιfi ιn ιn ιn ^ 'j π H θ H θ θi (!i σι σ) H θ H H H N θ N H θθ « ιn ιn ιn ω u) « ^ i "»

OO C C CO m c^ rO OO CO CM CM CM CM CM CM CM CM CM Cg CM CM CM CM CM CM CM CM CM CM CM CM iH iH iH i→ CM CM CM CM CM CM CM C^ iH iH iH iH iH rH rH iH iH iH iH iH iH rl iH iH iH rl i-H iH iH iH rH iH rH iH rH i→ rH rl rH i-H rl iH iH lH iH r^ c m m co ιθ rH r-- ι-ι o

N σi o H H|ⁱ σi O N Φ ιo uo o ri o o '3^, M w ^ <I^ ιI) 0 σι o ω m o3 ^ w ιn ^ ιn a3 CD m Λ O H H ιη ^ o ^ Ol ω o O H ri H ιη H ^ ^ co ^ oo oo (Tl lO ιn ^|i) ι ln "J ^o ^ ∞ r- oo σι (I)

CM CM CM CM CM CM OO CM CM CM C CM CM CM CM CM CM M CM OO OO OO OD OO CM CM CM CM CM CO CO OD C CO I^ Ovl CM CM CM CM CM en

"tf f co vo cM θ o co o ιo m 'τ r-- Ln t-~ ri ri oo oo ιιoo oooo cαo3 " oo r^ ι ιo ro σ o r^ ιn 'tf θo «tf ^ β ^ ^ cM σi " r~ c ι-H θ r~ ιn σ'i r-i "tf θ cn 'j^« ιn oo ri o cn r^ o co co co ι^ ιo cM oo co co oo co r~ oo r^ ιH "tf < C in ^^, oo ι θ ι-ι ι o co ι r^ ιn oo cn n 'r cn ι→ c r^ cM ιH r~ co (η c o p-- "tf θo oo ι-H ι "tf θ H in o ιn r^ o c r^ o ^r co ^r kθ in m ^ σi ^ m H N Φ tM icno σi M- i^ Mη H in αi σi v i i tM CM a Λ oi ui o o o σi Φ o o

CM CM rl O CM rl CM CO CM CM CM CO CM 00 00 "tf O CO r-~ lO C 0 CM CM rl o m c r^ r- Φ n tn ^■sr in o r- ^o o r- m m vo r- r- oo cn cn o o cM rl rl rl rl rl rl rl rl rl rl rl rH O O O O O rl rl rH rH rH rl rl rl rl rl rl rl rl rH rl rl rl CM CM CM rl rl rt rl rl rl i-H rl rl rl rl rl rl rl rl rl rl rl

o io io io r- o |To] o Ho rl rl rl rl rl NCM NCM rl rl rl rl rH

CO PQ C „O P„Q C„O m.-- c₁_oH m_W ωμ« cMQ- m_J pHQ« ωHM HQ oHHa mH-, mHM ffl- cHαH cHQ-, cHQH mH« pHQ-l PPQQ mffl pCθα ωω mCθ m α Cθ ω m

Ha Ha tf tf tf tf tf D D D D D D D D CO CO CO CO CO CO CO CO CO O O O U O CJ O C ^QS oS oS OS OS CS pS X X X X Z Z Z Z Z Z Z tf tf rtl H " i- ^" i- - H ^" H ^" cxi xi cxi xi xi cxi cxi Cxi x x x x x x x x x ps ps p Λ ^ c5 ^ ⁽i !- a; a! κ a: B. a; fi j a Hi a ιJ j j ι a > > > tf tf tf tf tf ^j H H ,-a ι- ι- ι- .-a H Ha ι-a Ha H ι- ,- H H tf tf tf tf tf tf tf tf tf tf EH EH EH EH EH EH EH CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ rl CM rl CM CM rl CM rl CM CJ CJ tf CO tf PQ CJ Q Q tf CO CJ Q Cxi CO tf pQ c α ω co a a tf CO CJ tf υ υu t CQ CJ Q Cxi Cxi

O S3 J CJ J O S3 c cj υ CJ CJ c O S3 CJ CJ CJ CJ U S3 CJ O S3 U U U U Z U 2 2 uozuυoυ CJuozuu f o a U U U U O Z

00 rH

° 2222222222222222222222222222222222222222222222222222222

O o o oo o o o o o o o o o o o o o o o o o o o o oo o o o o o o o o o o o o o o o o o o o o oo o o o o o o o

S H ^H E^H E^{H H} H EH E^H EH E^H E^H H EH EH EH E^H E^H E^H E^H E^H E^H E^H E^H E^H E^H E^H EH EH EH EH EH EH EH ^H EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH

P* tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

Table 1

ATOM 1925 C GLN B 123 117. 209 27. 829 127. 618 1. 00 46. 32

ATOM 1926 O GLN B 123 116. 221 28. 495 127. 310 1. 00 46. 58

ATOM 1927 N TYR B 124 117. 635 27. 701 128. 869 1. ,00 43. 86

ATOM 1928 CA TYR B 124 116. 907 28. ,360 129. ,927 1. ,00 42. 11

ATOM 1929 CB TYR B 124 117. ,518 28. ,026 131. ,294 1. .00 41. .58

ATOM 1930 CG TYR B 124 118. 722 28. ,851 131. ,700 1. ,00 42. 91

ATOM 1931 CDl TYR B 124 118. 594 30. 204 132. ,041 1. ,00 42. 19

ATOM 1932 CE1 TYR B 124 119. 697 30. ,951 132. ,453 1. .00 42. 26

ATOM 1933 CD2 TYR B 124 119. ,989 28. ,269 131. ,781 1. .00 42. ,35

ATOM 1934 CE2 TYR B 124 121. ,096 29. ,005 132. ,193 1. .00 41. ,60

ATOM 1935 CZ TYR B 124 120. ,946 30. .339 132. ,527 1. .00 42. ,23

ATOM 1936 OH TYR B 124 122. .046 31. .048 132. .944 1. .00 41. ,91

ATOM 1937 C TYR B 124 116. ,889 29. ,866 129. ,672 1. .00 41. 35

ATOM 1938 O TYR B 124 117. ,800 30. ,423 129. ,065 1. .00 40. ,98

ATOM 1939 N LYS B 125 115. ,821 30. .507 130. ,126 1. ,00 40. 27

ATOM 1940 CA LYS B 125 115. .643 31. ,934 129. .978 1. ,00 37. ,43

ATOM 1941 CB LYS B 125 114. .227 32. ,210 129. .493 1. .00 37. ,31

ATOM 1942 CG LYS B 125 113, .893 33, .657 129, .377 1, ,00 37. ,20

ATOM 1943 CD LYS B 125 112. ,614 33. ,812 128. ,619 1. .00 39. ,57

ATOM 1944 CE LYS B 125 112, .257 35. ,271 128. .448 1, .00 41. ,27

ATOM 1945 NZ LYS B 125 111. .167 35. ,402 127, .445 1, .00 43. ,99

ATOM 1946 C LYS B 125 115, .891 32. .583 131, .331 1, .00 36. ,74

ATOM 1947 O LYS B 125 115, .408 32. .110 132, .368 1, .00 35. .41

ATOM 1948 N LEU B 126 116. .662 33. .662 131. .312 1. .00 36. .70

ATOM 1949 CA LEU B 126 117, ,005 34. ,383 132. .522 1. .00 36. ,52

ATOM 1950 CB LEU B 126 117. ,877 35. ,586 132, .186 1. .00 37. ,09

ATOM 1951 CG LEU B 126 119. .375 35. .336 132, .036 1. .00 37. .50

ATOM 1952 CDl LEU B 126 120, .054 36. .676 131. .792 1. .00 36. .55

ATOM 1953 CD2 LEU B 126 119. .933 34, .674 133. .298 1. .00 36, .86

ATOM 1954 C LEU B 126 115. .802 34, .859 133, .298 1, .00 36. .94

ATOM 1955 0 LEU B 126 114. .878 35. .432 132. .732 1, .00 38. ,21

ATOM 1956 N GLY B 127 115. .823 34, .635 134. .603 1. .00 36, ,87

ATOM 1957 CA GLY B 127 114. .716 35, .075 135, .417 1 .00 39. ,12

ATOM 1958 C GLY B 127 114, .457 36, .539 135, .139 1 .00 40. .81

ATOM 1959 O GLY B 127 113. .333 36 .949 134, .886 1 .00 42. .21

ATOM 1960 N SER B 128 115, .515 37 .332 135 .174 1 .00 42, .67

ATOM 1961 CA SER B 128 115. .409 38, .761 134, .929 1. .00 44. .81

ATOM 1962 CB SER B 128 116. .826 39, .362 134, .873 1, .00 46. .60

ATOM 1963 OG SER B 128 117, .725 38 .527 134, .145 1 .00 48. .48

ATOM 1964 C SER B 128 114, .618 39 .107 133, .658 1 .00 44. .99

ATOM 1965 O SER B 128 114, .206 40 .256 133 .465 1 .00 44, .55

ATOM 1966 N LYS B 129 114, .393 38 .113 132 .803 1. .00 45, .58

ATOM 1967 CA LYS B 129 113, .674 38 .336 131, .552 1 .00 46. .27

ATOM 1968 CB LYS B 129 114, .514 37 .864 130, .358 1 .00 46. .90

ATOM 1969 CG LYS B 129 115, .839 38 .592 130 .121 1 .00 49, .02

ATOM 1970 CD LYS B 129 116, .341 38 .312 128 .697 1. .00 49, .89

ATOM 1971 CE LYS B 129 116 .306 36 .810 128 .359 1 .00 50, .63

ATOM 1972 NZ LYS B 129 116 .042 36 .545 126 .905 1 .00 49, .75

ATOM 1973 C LYS B 129 112, .311 37 .646 131 .461 1 .00 46, .33

ATOM 1974 O LYS B 129 111, .671 37 .690 130 .404 1 .00 46, .91

ATOM 1975 N THR B 130 111 .860 37 .018 132 .544 1 .00 44, .73

ATOM 1976 CA THR B 130 110 .581 36 .307 132 .517 1 .00 43, .35

ATOM 1977 CB THR B 130 110 .621 35 .062 133 .386 1 .00 41, .73

ATOM 1978 OG1 THR B 130 110 .608 35 .455 134 .763 1 .00 39, .55

ATOM 1979 CG2 THR B 130 111, .874 34 .249 133 .090 1 .00 41. .36 Tf Tf r-

IN

O i-H I— 00 (Jl O Ln rH CD "tf 00 00 ^ m in co in o oo oo r- 'T CM c M r- r^ M ri o rv o c o oo io oo oo oo ri -q- cn ^o σi cn "=3 ro cM c r- ιn r~ ιn r~ © co oo r j o ^r m ^ σi o ro ri o ιn oo m cM co oo oo r ιn r- o ri "tf ri rH "tf rH CM θ co oo Lθ H U) rl O CD If) O X I HO H r~ oo co 'tf r-- r~ '}' 'j' CΛ §

C O D OO "tf ιn CM O rl CM CM CN OD rl O ri oo r^ o r^ r- oo 'tf oo cn r- co m oo o c i_'i mu) O-^'_' i 'tf ^ι^, "tf "tf i o o o MJ <τ> r-ι oo oo rι o Λ r- co

^* ^3* ^ * ^1* ^ϊ¹ '^J* ^ * ^3* ^* ^ * *^* ^* ^3* ^3^ ^ * "tf ro oo oo oo co oo oo oo oo oo oo ro oo t- T - ~OO ~OO OO OO OO OO OO OO OO OO OO OO CM CM OO CM CM CM CO CM CM CM υ ooooooooooooooooooooooooooooooooooooooooooooooooooooooo

AH ooooooooooooooooooooooooooooooooooooooooooooooooooooooo l rH rl rl rl rl

H W "l' co N (n m Φ a ι rt oo ι H (N Ol ^c) co H l (^|^ H H O co ^ι ^^ σι ιD ( ) ^l ιn o rι ι ^ι o ^ lD ^o ^ι ιη ^ o ι»l ^^ co o "tf cn co co ri o (H ιn H ω o o H U) N in ^ ιn c>) in (n iM M m o H θ ιn o ιθ h iβ 'j (jι r- o3 (Ji o3 ri ιn N m r- "» H θi H H (D in o ^ r- o oo oo m o cM Lo co (Jι σl ID Φ Φ O N O (\| r^ o ∞ Φ (Il Φ ι ι^ι ιn o ^ (n ^^ ffl ^n n H r- ^ι ιO H lD O o^ ιn ^D H O Φ <Λ "J^, (D ^B l P^ ^ o CM O ri cM CM ri in cn ri H O o σι H o

■ςr ri r— oo so r- oo o io i H io ui flΗ in H in in - o ^tf cn r^ ιn ιn ιn ιn cM ιH θ ιn cn o oo co r-- r~ ro ri co cM co o "tf r~- cM CM θ co co ιo co rl CO CM CM rl 00 rl H CN H N Φ O N ^ tη σi io r- Λ r- O iH r~ oo c c c rH io o r-- c o r--- - oo o H o o ro o "tf ro cD i-i 'tf C o ri cD o cn rl 00 oo o r-~ lO rl ro cθ ri ιn o o o oo o cn co ιn r- ri lB IO O ( lfl rl O M0 * l» n H (Jl (M rl 00 0D lfl rl n « <D in O >0 IO U 01 ^ ιn βl H

^ ^ ιo ^ ιo ιn ^ co ^o ^• (D ^fl ι ^■ ^D ^D ιn ιn ^ fl' ^o ^o u^ ^ ι'ι | (ι H H lJι <Il CD (I) o ol o O H σ( oo o O H l H ^ι (J^ 03 (D r> ^ <Jl m ιJι ιcι ro r oo co co ro ro c c co co ro oo n oo c oo oo oo oo oo co oo oo o oo oo oo oo i CM CM CM oo cM oo n oo cM CM n ^ ιn ^o (I^ m H ιo H o o o o ιn ι ^ <D Ol ^ n oo n o ιO l^ H ^ H "I ^ » ^ ^n o (Λ P1 "^^ι o ιJ) oo N lβ Λ co ra c>ι ^ N lI3 H 'J ιn Φ H '» 0^ ιn M N ^ o Φ Φ 0^ ^ Φ Φ (I^ ιJι ω ffl N v ^ o o ιn Φ o m ^ m ιn ^ c^ι σι O Φ n H ln Φ ^ o n H (<l Λ ^- (^ι ^- ιn (0 ^> 0\ ιn ^n n ^ N o ra ω l >J l o (D N <Jl f^ tι o w N W H ι ^ Φ Λ ^ o ω ^ ln ^ι ιn tD o ω H (O ιn H π o^ι oo ιJι ^ Φ H O 'J 'l^, N co ^ n Λ

<Tι <yι oo r~ ι ιn 'tf -tf θθ M <N CM CM CM c "tf in co r~ oo o oθ 'tf ^ ιn «tf ^ 'r "tf 'r "tf θ ιn r~ oo cn cD co ^ o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o

H H H H ri rl H H H H H H rl H H H H H H H H rl H rl H H H H H H rl ri H H H H H H ri H H rl H H H H H H H H H H H H H

o o H H H H (^ι ^ι (^l N (l N N n n ιo ι^ "l^l ^ ^ ^ « "J ^ ^ ιn ιn ι ln ιn ι ιn ιn ιn Φ >D Φ U3 ιD ^ ^ ^ ^- ^ ^- ^ m (D oo tD _) oo m oo oo n oo oo oo co oo oo ro oo oo m ro oo r ro co r ro c M oo oo n oo oo co co oo oo oo ro oo ro ro ro co co c oo co c^ ffl ffl pa m m ω ω cQ pa pQ PQ PQ a oa oq pa m ω pQ m co cQ co m co ω ω pQ ω m Q a cQ Q CQ pa oQ m m

OS PS X X X X X X z z z co co co co co co co co co Cx] Cx] Cx] Cxi Cx] Cxi x] Cxl D D D D D D D a a H! π x.-a xHI o OS oOS oPS oOS oOS oPS oPS j J H! a j j j z HI Hzi zHI zπi z.a za X X X X X X X X X Ha Cxl bl Cxl fxl lxl Cxl txl

H EH ϋ o cj ϋ ii αi C-i αi CLi C-i Ci ei cj c c cj ø cj cj c cj c ^■ ti j j ,a a J HI rl CM CM rl rl rl CM ft Q tf CO CJ O Z CJ J Z J CJ J CJ J o tf tf CO CJ Q Cx] Cx] tf CO CJ CJ Q tf CQ CJ Q Q

CJ z J CJ o z J J J CJ o z U02U tfUcoUc UαUωZcoUOZ ΛUJUPHU o z CJ CJ C CJ CJ CJ O Z U ϋ U U U U

O H t^ι ^η v ι Φ ^ m o O H N n f ιn ιo ^ ω m o ri ι ιη t ιn ^ ^ o3 ffl O H l (η "f ι Φ ^ ∞ m o rt ^ι ^η l' ιn ^o ^ oo o o H (l ^o ιJ

B! IB IX) ∞ 03 C0 tD CD (10 (0 (!l ⁽Il lJl Λ m 0\ 01 (Il !!i m θ O O O O O O O O O H ri H H H ri H H H H r (\I N N ( N rN^, N N < P0 (n fl r^ll in

00 oo σι σi cn cn oo σι cn <τι σι cΛ cr> cn cri cn cn cn cn cn σ> o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o rH

© 22222222222222222222222222222222222222222222222 o oooo tf tf tf tf^Ho tfE^Ho tfEH Eo tfHo tfEHo tfEHo o tfEH Eo t_fHoEt_fH Eo tfHtEH EoEo f tfHt_fHo tfEHo t_fEHo tfEHo tfEHo t_fEHo fEHoEHoEHoEHoHoEHoEHoEHo fEH Eoo fHtE_fH Eo tHoEo t f tfEH tfHoE o tfHtfEHo tfEHo tfEHo fEHo o 2 ttfEHoo tfEHt_fEHo 2 t_fEHoEHoEH EHoEHoEHo2 2

EH EH EH E EHo2o2 EH EHoEHo22 ttf tf tf tf tf t_f t_f t EHoEH

Tf trt s n cD ^ H Φ ιn (n ri lD n n o ^ ^ r) ra co o ι ιn oo ^ ^ι ^ N ι ^ n H ι ω o c^ι (lo m ^O Φ rl ^ o3 o^ o (^l (^! ιn m (D o m o "l' co (N o N W CD ιn Φ O ∞ Φ fO O ιn ri N m ιn ιn ι H O^ Φ N Φ H ^ ιη c^ι ι cJ Λ Φ l ω v (Λ f^|1 ιo ^n o ^ ιn ιn H N ^ N H σι n ιn (D oo ^fi ^ β

CΛ ι ιn ι m ^^ H O (D (Il o ιD r- co <τι o ^^ (^ <f O H H H O tIl <Iι o o ι^,^ ιn ιn o ∞ Φ ^t) ^D (Tι Hl^, ^β ιn ^O ln r• ιn ι» O ln (D ^ o m r^ c^^ oo

CM CM CM CM CM CM CM iH iH CM CM CM CM CM r0 C CO r0 00 r0 C0 r C0 CM CM 00 C^ 0000 00 "tf ^ 'tf C0 00 00 ^ 'r "tf "tf "tf ^ "^ f-1 OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

( co N (η m (η

CTl

CM r ^o o c ri o r^ o oo cM θ o o cM c oo «tf Ln r~ rH co ri co ιn 'j' r- •>tf ι-H oo oo co ro cn co cM θθ io m r- m oo o o τ cM θ r- CM -tf in oo ro σi ri o cM CM cθ ri oo m σι m o ri oo o o cM θ co t-~ oo cM co cn cM θ ι^, "tf i o O 'tf Ln oi r o o cD H 'tf c co 'j' CO M tr oo r^ r oo t oo r^ cn r^ cn oo σι ιn oo ιo co oo oo r- o oo co oθ "tf oo r~ <tf in θ ri co θ ri m r- co oo m m m m θ 'tf oo ιn <tf m cn ιn ro o cM θ ri σι o cri cM m cM CM ri cM m m oo oo ^r ιn oo θ "tf in co r ri o o o cn cn cn cn cn oo oo cn cD io in ^i' -tf m in 'r oo oo cM ri o cn o o o cn o 00 < CM rH D CM O CM D OO "tf

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rH rl rl rl rl rl rl rl rH rl rl rl rl rl rl rl rl rl rl m in m in m m m m LO ^O r^ ι o H co l "tf 'r o ω in t n o w (η ai 'f H U3 o ι » ιn Φ ^ ^ ω ω w Λ (η c^ ^ n N H O O (D '^ ι N lD rη t^ι t N^, ^ ^ ^ tD ^ π^ ^ ιn tO "^ ^ι t^ι ι ιn ^ co ^ ^ o ω ^ ^ ιJι σl N O o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o cn cn σi i ϊ σi o o o

H H iH H H H H H H H H H ri H ri H H H H H H H H H H H H H H H H H H ri H H rl H H H H ri H ri ri H H rl rl rl

oo cn cn oo oo oo oo oo cn cn cn cn o o o o o o o o i-H ri ιH ι-H rH CM M CM C CM CM CM C o o r rθ 'tf 'tf tι^, "tf 'q^, cn c c cn crι c c c o o c o o o c c r o c ) c o ^ι^, 'tf 'tf ^r ^r 'r "tf "tf 'r '3" c cQ cQ o ω m pQ oa m ffl ra m ω ω ω cQ ω pQ cQ cQ m o cQ o cQ m pQ m m m o co cQ m m cQ cQ CQ CJ υ cj u u u u u υ

D Cxi Cxi Cxi Cx] Cxl Cxl Cxl Cxl Cxl Cxl Cxl D _D ^{^}D ^{^}D ^{^}D D_ _- ^{^}D O_ O_ O_ O_ O_ O_ O_ _^ .-- _{e e}_, _E_, _E__{t E}-, _E-, p_C; e; p_; pi o-; o-; «a fa; '=C ₍tf tf 0

Cxi a a a a . a . .a . a , a , a a a cxi cxi cxi ω cxi cd ia ω ps ps PS oS i-s ciS c c cjxi ccxxii ixi ω id ti ω „ .i . ω ixi ci ci cxi cxi H ra - - ι-a w eq ω Cxi Cx] Cxi W CJ PS

Ha Oj Ci Ol Ll C-l Cli Cl CLl Hi Oi Oi Hi Hi Hi a a Hi Hi Hi Dj ft ft Oj fc Qi iii " 2 "2 22 2 222 CO CO CO CO O - -O- tf tf tf tf 2 22 22222

CM rl CM rl CM tf CO CJ Q Q Cx] Cx] CO tf co c Q a Q tf CQ CJ tf CO CJ Q dl tf CQ CJ tf PQ CO CJ Q Cxi tf

2 U U U U cj 0 u υ cj o υ u cj u υ CJ o uu u uυ ozu υυto o 0 o z O J o o o υ cj u O U J O J U O υ z

CM CM CM CM CM CM CM CM C^

O H

rrt js

© o oo ιn "tf "tf ri oo r-- oo oo o M3 o r- M σ^ vo oo r~ oo cM σi ri ri r- o M m r~ r- LO LO r- H m ι oo oo "» N H σι σi H "tf 00 CM rl SD m 00 "tf o iD in 'tf UJ c n c r ^o ri oo in vo ^

H ^rδ ^ a ^ ^ ιn ιn o ^ (Iι co o ιn ( v ι^ι o H H O In ∞ lJl H ^ o ln (η c^ * « ^ ^ t^|l <^^, ^ (^ι o M H ^ H co ω ^ ol ffl ι ^ ^ n (^,^ ιn t£⁾ ι^,^ l U ιn ιn ιn ιn ιn ιn ιn 'r ^ ^ ι "tf 'r «tf "tf 'tf ^ 'tf 'tf f o co ^ co co o o r o o o o oo o o o cM M ιH r^ AH ooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooo

ιn r~ r~ r^ r^ r~ oo o oo co ^ θ rH o M C rH Ln "tf in ^ o «tf m θ ιH θ θ ^ o ^ OT co (^ o) ^ "tf i r~ r~ r-- cn cn cn σi cn cn σi cn cn cn σi o o o o o o o o o o o o o o o o o o o σi o cn cn cn o o o o o o o o o

')' θ cθ ri oo ι m r~ o cn 'g' oθ ri r- oo o cθ H m o r- CM θ r~ m rH ^•^■ oo o o in ro tr o co vo co oo oo o oo co o cri 'tf in 'tf O 'tf cn o cn in o o θ ri in 'tf ri ιo ιn 'tf o oo 'j' in c ^lo co ri r~ σι o o c cn rH ri co r~ σι r~- σι σi "tf "tf r~ ιo oo r-- M CM -tf <^r) "tf rH H rH iΛ co r-~ o cM in o ιo c r- SO i in o "tf Co σi "tf r~- r^ o uo co cM m ri σι co c cn c r~- o cM ^o ⁽o cM "tf CM r- i m -tf >i3 CO "tf τtf OO CM rl O rl CM rH CM CM OO rH O O rl Cn σι θ σ^ θ r- r- r~ I— co in m in o in tn m n m m in m in in i m m m in in in in m in 'r ' in i' m 'tf 'tf itf ^* ^* * * "^S¹ "^J¹ "^J¹ ^S¹ "^f ^* ^^ ^ ^ ^ ^ "tf _"tf U3 l ιΛ n r co

0 (Ii (Il O co ^ Φ Φ ι Φ Φ ^ ιn ^ π '^ ^ ^ ιn "» ^ ^ M H N H O H n "f H N n "» H ι tn cl m o3 o^ m o ^ to o cn ol <Jl o o ^^l (^^ o cn cn o cn cn cn cn cn cn cn cn cn cn ^ cn cn cn cn oo oo cn cn cn cn cn cn cn cn c^

o o o o o o H H H H H H H N N N N N i'i n t i'i i'i iη iη if ^ fl ii if ^ v ^ ^ ^ v ^ in in in in in in in in in in in in in in ic iβ io io in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in io in fl in w υ o u o u u o υ u υυ oo υ uυ υ o υ u υ cj u c υ cj cj u cj o cj u cj o o cj o cj cj cj o cj o cj υ cj o o o o cj o c cj cj o o o o o O πa H H H Ha Ha i-a tf tf tf tf tf o o o o o o o o c-ϊ ps ps c-ϊ c-J c-i c-i oS QS ps s cii Pj c^ c oS c.; c£ -; pS tf tf tf tf tf tf tf H H H H Ha ps ps ps PS ps ps ps x x x x x x x χ ps ps ps

Pι ⁽lι Λ D( ⁽l( αι > > > > > ιa; ^ rt rt; fc ft O) IX Oι O< ft H H Eι Eι EH EH h tH Eι H H tH tH EH B H EH Eι H H tH tH H tH tH EH H tH tH fH

Q tf PQ CJ tf PQ CJ CJ tf CO Q tf CO CJ tf CO CJ Q Cxl Q Cxl cO B tf CQ Cj α ω ω Q ω N tf CQ CJ cj cj υ υ o o z u o ou υ o z o u o o z c υ u υ u o z o o o υ cj o c o o cj o z o o o υ α cj o z cj υ υ υ o z o o o

O H N n 'τ ιn Φ ^ ra m o H N n ^ ι » ^ ω o^ o H N π ^ ιn ω ^ o3 n o H N (η v ιn Φ ^ co ffl O H (ι r^ ^ ιn Φ tD Ol O H (^ι n ^

» 01 01 (JI W tJi m m <Ii m O O O O O O O O O O H H H H H d H H H H \I N « N N (\I N CN N M (^,l (^») n 0 n fl l») M r (^»l V <f "f <r ^ o

(iι θ Φ θ o r- 'q' O r- in co co cθ ri _"tf rθ ri ro oo co co co ro O O O OOO O o o OOO

r r- O ri Ln ro m r-- ri oo oo M ri ι _"tf θ 'r rl i-H rH i-H i-H rl

N in oo o ^ m Φ θ Φ Φ ci Φ ιn Λ N N ^ o o ω ιn « N N ω N ω ^ m Φ 'j H o ω ι» H iη ιf in Φ N in ιn ιc Φ "ii (jι sι ι ιn (Ji oι iD o t^ ^ ω 'J H N W Φ ^ o o c_N' ^o ^ ιo (η H H ^o o ^ Ol ^D (D ^fl ιn Hl• ιn ll^ o ^ H O ^ o o (^,^ r- ι^ oo ^ ^ H Iη ιn Hf ^ cΛ o ^ ^ ^^ !N ιn 030 (η o3 ^ ι H O ^ o u^ ιf ^ (Il N ιη (s o o n Φ n ^ n ^ ^ W ln m fll ( ^ ^ "^ O H ι ^ N ω n m n H co oo ^^ H f^ "^ ^o ι» N O ^

_H o m m (lo ^ m α! O _{O O} H o m o1 co ^ ω ω ln ^ ιn ln » ιo ^ (^l n Λ H ^ι ιIJ ^ co o3 ^ m ^ ^fl •!l• ^ n l r^ co (Jl O oo σl co ^ "tf 'tf r r o oo c r M 'tf 'tf 'tf 'tf 'tf o oo r oo oo oo o o c^ o co o o o 'tf 'tf oo o o M co o^

H ^ ∞ H (Il ^ (D O rl o ιC 5l H O H O Ul o n ιfl Φ O (I> t>ι ^ⁿ N ( ιn ^o βl O ιn o c » ^ι o (o o ^o ι<l ιJl O tD 01 <» (^ ^ aJ H ln H ^ N N o ^ o σi r_^ ^ o c co co co cM r_^ o cn co o co c_M i_H L_O C_Λ L ' ro ' CΛ cn iH in r_^ o cn i rH ∞ c r^

<^' o ω ^ ιn n <f ^ N ι ^ v ^ o w Φ Φ ^ O H (^ι tn o (n ιn fo ^ ι N ιn tD r^ ^ N oo o fD ^^| H ^• (o o ω o H ^η ^ ctl O rl H O ι^ ^^ ) o m ^ co oι o ^ ^ ιo ιo ιn «^| ιn 9 i^r) '5^ι (n 'j ^ m ιn ui h in ιci '» "j ιn ⁽i) ^ f- ι») N N θ o o ιιi H θ H H H N f H N θ H θ H N θ o cn cn co co ∞ oo cn co oo ∞ co co oo oo co oo oo co co co cD Oo oo oo oo co oo oo oo ∞ oo oo oo oo oo oo oo oo r^ oo oo oo ∞

ω ^ ιo ^ ^ ^ ^ ^ ^ oJ co o: oo co o3 (I! lJl m m (Λ (I^ o o o o o H H H H H H H H (^^ (^ι t^ι ^ι ^ι ι«l n n (^,) ι (^,ι ι^,) t n "f "^' 'ϊ <I ^ ιn ι in in in in i in i in in in in in in in i in i in in in in Φ Φ Φ Φ Φ Φ Φ Φ Φ W Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ ω Φ W Φ Φ Φ Φ Φ io io rl H H rl rl H H H H rl H rl H H rl rl H H H rl H H H H rl H H rl rl rl rl H H rl H H H ri H H rl H H H H ri H H H H H H H H H cj cj υ υ υ u υ o u υ cj υ o u u υ o u u υ υ u υ υ o υ υ υ u υ υ υ u o υ o υ o u cj υ cj o υ o o u υ o o υ υ u u υ

Λ Λ Λ JS ttJ tti K lli Bi O O O O O O O D D D D D n t t t tn H EH H tH H tH H Ei D D D D D ra i W W tO tO W tn n n t W tΛ t D D a a ci [i cχi χi ci c-] c-; c-. p os os oS H Ha ι-a H H3 X x x x x ci ω ci cιi ca cχi ω cχi Ha Ha

H H H tn w B tβ w n t- i αi t- oi ^ Qj u u u o o j a j j J S S s ∑ s g s s u ϋ o o o j a Hi Hi ^ a a ^ a a Hi ia H Hi a a

CM

CJ tf CQ CJ Q tf CQ CJ tf CQ tf CQ tf PQ CJ Q Cx] tf CO tf CO CJ Q U CO tf CO tf cj o o z υ υ o cj o z o υ u o cj o z o o υ o z o cj o o z o υ o co υ u o z cj υ o o z u u υ o cj z o o z o cj u o z o ιn Φ ^ ω m o ι^ N ιD "ι^, ιn ιD ^ (D (Il O H N tn ^ ιn Φ ^ oo σ^ o H N (n * ιn Φ ^ co w o H N n ^ ln Φ ^ co Λ O H N r^ ^ ιn ω ^-■ ()o cfι ^ "tf 'tf 'tf "tf in ιn ιn ι ιn ιn ιn ιn ιn ι ^ co co ιo co ιo ιo >o ιo iΛ t^ r- r~ r~ r~ ι^ r~ t^ r~ r~ oo oo oo oo oo oo ∞

o22o2222 22 EHoEH EHoEHoEHoEHo22 EHoEHoEHoEH o

Table 1

ATOM 2200 CB LEU C 165 78.764 37.376 118 .989 00 32.15

ATOM 2201 CG LEU C 165 78.678 36.482 120 ,242 00 32.85

ATOM 2202 CDl LEU C 165 79.467 37.102 121 ,383 00 30.15

ATOM 2203 CD2 LEU C 165 77.244 36.289 120 ,648 00 32.03

ATOM 2204 C LEU C 165 80.778 36.046 118 ,571 00 31.11

ATOM 2205 O LEU C 165 80.331 35.112 117 ,914 00 28.78

ATOM 2206 N HIS C 166 81.766 35.908 119.454 00 32.82

ATOM 2207 CA HIS C 166 82.404 34.618 119.736 00 33.88

ATOM 2208 CB HIS C 166 83.919 34.710 119.632 00 35.77

ATOM 2209 CG HIS C 166 84.413 34.914 118.243 00 41.33

ATOM 2210 CD2 HIS C 166 85.227 34.159 117.469 00 43.37

ATOM 2211 ND1 HIS C 166 84.069 36.015 117.487 00 42.96

ATOM 2212 CE1 HIS C 166 84.651 35.930 116.303 00 44.52

ATOM 2213 NE2 HIS C 166 85.360 34.814 116.267 00 45.66

ATOM 2214 C HIS C 166 82.068 34.159 121.151 00 33.19

ATOM 2215 O HIS C 166 82.627 34.669 122.132 1.00 30.45

ATOM 2216 N ALA C 167 81.152 33.198 121.249 00 32.79

ATOM 2217 CA ALA c 167 80.745 32.641 122.534 00 33.37

ATOM 2218 CB ALA c 167 79.227 32.558 122 ,627 00 32.85

ATOM 2219 C ALA c 167 81.352 31.252 122 ,595 00 33.26

ATOM 2220 O ALA c 167 81.205 30.459 121.654 00 32.87

ATOM 2221 N VAL c 168 82.027 30.955 123.702 00 32.58

ATOM 2222 CA VAL c 168 82.683 29.669 123 ,849 00 31.16

ATOM 2223 CB VAL c 168 84.114 29.747 123.277 00 30.30

ATOM 2224 CGI VAL c 168 84.071 30.079 121.815 00 29.14

ATOM 2225 CG2 VAL c 168 84.911 30.820 124.018 00 29.56

ATOM 2226 C VAL c 168 82.794 29.160 125.283 00 30.45

ATOM 2227 O VAL c 168 82.688 29.921 126.245 00 29.08

ATOM 2228 N PRO c 169 82.971 27.842 125.436 00 30.30

ATOM 2229 CD PRO c 169 82.654 26.785 124.457 1.00 28.93

ATOM 2230 CA PRO c 169 83.110 27.285 126.781 00 30.64

ATOM 2231 CB PRO c 169 82.783 25.806 126.581 00 28.08

ATOM 2232 CG PRO c 169 83.173 25.558 125.144 00 28.90

ATOM 2233 C PRO c 169 84.562 27.535 127.237 00 32.73

ATOM 2234 O PRO c 169 85.511' 27.347 126 ,458 00 34.04

ATOM 2235 N ALA c 170 84.725 27.979 128.482 00 32.44

ATOM 2236 CA ALA c 170 86.039 28.261 129.046 00 31.35

ATOM 2237 CB ALA c 170 85.928 28.414 130.554 00 31.49

ATOM 2238 C ALA c 170 87.053 27.175 128.712 00 31.45

ATOM 2239 O ALA c 170 86.693 26.005 128.575 00 30.29

ATOM 2240 N ALA c 171 88.314 27.588 128.580 00 31.27

ATOM 2241 CA ALA c 171 89.436 26.705 128.280 00 31.34

ATOM 2242 CB ALA c 171 89.218 25.326 128.910 00 30.46

ATOM 2243 C ALA c 171 89.696 26.571 126.793 00 31.73

ATOM 2244 O ALA c 171 90.701 25.989 126 ,387 00 33.59

ATOM 2245 N LYS c 172 88.800 27.115 125.981 00 32.03

ATOM 2246 CA LYS c 172 88.960 27.043 124.533 00 32.88

ATOM 2247 CB LYS c 172 87.599 27.256 123.846 00 30.96

ATOM 2248 C LYS c 172 89.987 28.080 124.030 00 33.39

ATOM 2249 O LYS c 172 90.207 29.110 124.665 00 32.67

ATOM 2250 N THR c 173 90.623 27.773 122.902 00 33.31

ATOM 2251 CA THR c 173 91.600 28.649 122.261 00 32.28

ATOM 2252 CB THR c 173 92.572 27.846 121.364 00 33.35

ATOM 2253 OG1 THR c 173 93.408 27.012 122.176 00 36.76

ATOM 2254 CG2 THR c 173 93.419 28.780 120.513 00 30.69 in r~ oo m OO OO 'tf Cn io oo vo oo ri θ ri θ ri o <M cn o oo r- co >o ιo <J3 ιn ^o r~ r~- crι oo o cn "tf 'tf θ CM rH o en en c_M co co r~ u₃ r- ^l _>D in co i io r~ ^r 't_f r _{M r}i o cM _CM

CM CM CM CM CM CM CM rl CM rl rl rl rl rH rl rH rH rH rH rH rl CM rH rl rl rl rl rH rl o o ri o o o o o o o o o o o o o o o o o o o rH rl rl rH rl rl rl rl rl rH rl rl rl rH rH rl rl rH rl rl rl rl rH rl rl rH iH rH o ^ ^ Φ ^ ιη n ιn (Λ ffl ω N (Jι ω ri Φ ω N N (Jl ^ ^ H ^ N ω o co ^ cO (B ω O H ^ oo N ^ m Φ ^ ^ ιn H αl co ^ tD ^β N ()o ^» ω ^ ^ (J\ ιn ^ ^ ιn N ι o m o "^ H 03 ι "r tn N N N lΛ ^l N M ^ (^l m "J ω o ^ m N tD co H ιη ^ ^ι v ^ » ω co m σι t^ι < o ω ^ tt^ι ι o ω o m H ιη ιn m ^ n ^ o a ^ o^ ^n m o3 ^o ιn m H a H ιn tD ^ ffl ιD αι o ol O N O (^ι o o301 to ^o o ι^,) ^ ln ^ ιn ^D oo ri H ^ H m σ^ O H M 'ϊ c^l (^l N ι ^^ N HJ ^ ιn ^ ^ ^ w Φ ^ lfl ^ ^ ^ ^O (B ω co o H H C^l ( o ro o oo ^ H ^^ N ιΛ ^ "I (D N ^f ^ '( ^ ^D ^

CM CM CO CO C CO C O0 CO C C C M 00 C C 00 C CO M r0000D 0D C0 CO 0000 C 0 "tf "tf "tf "tf "^

N ^ l N H O ιn o ιn ιn H H O Φ H <» ω o N ω ^ o ^ ^ p^ ^ M fl' H lD o ιn <Jl eo N O co ιn (o n ^o o (Jl "^ (l (D m '^^, σ ^o (^ι ^ n u^ m o o N N H ιη oo m ^ ^ o ^ H co co ri O H σι o o (!l ιη <Λ lD c, oo r- O H o^ ^ O '!l^, o w •» (!l ln ^ m (J^ ^ ^D ri ^D O ^^ co >^^, ^J ι ω H o n Φ to r1 N n ω W N ω ^ M ^ H (^ι O ln o Φ ^ N v Φ (D n ^ ln Φ tD H c^) ιn ^ σι σι ^s o ^ fl^| (») ι * "» Φ ^ ιn tD m Ol O H

O O H 0010103 H PI O H N O CIl H O θ m a) (!l ^ CO H ( O H H θ σi H H M N H O ri O (\I M H N H n Pl Pl ^ V in « ιn ιn «) lil l) σi cn cn en oo oo oo cn σ^ σi σ^ cn σ^ oo cn σ^ σi aa oo oo oo oo oo cn cn cn cn cn cn oo cn cn cn cn σ^ cn cn cn cn cn cn cn cn c^

n ιD 'J "l' fl "f "J "^ ιJ ι ι ιn ιn ιn Φ Φ Φ Φ ω w Φ Φ Φ ^O Φ ^ ^ r~ ^■ (Il oo ∞ oo to o: (Iι m w m <J ^ι n o o o o o o ri H H H H H t^ r-- r~ r^ r~ r~ r^ r^ r^ i^ r^ r^ r~ r^ r~ r-- r^ r~ r^ r- r~ r~ r~ r~ r-- r^ t~ r^ r~ iH rl rl iH rl rl iH rl iH rl rH iH iH iH rH i-H iH rl rl iH rl rl iH rl iH r-l iH iH rH rl rl rl rl rl r^ o o CJ CJ O O o uuuuuuuuϋυυuuuuϋϋuϋuuuuuυuuuuuuuϋuuuuuuϋuuuuuuuu os os rl Hi J J co nwnM WH t- W W W u ω ω ωt- m tΛ ωmc tn wtow c woooo oo opi o- Λ tf Qi oi oSei ttlβifli oJ a a t tf tf x x X X X a x X X X X x x x S os os p α os ω ω td td ω ω ω ω cxi ci ω xi

> > Hi Hi Hi rl rl J IJ HI HI rl CJ CJ tf CQ tf pq cj α α ω cxi co co c a tf co cj tf CQ CJ tf PQ CJ u o z u o J CJ CJ O Z υ o o o z CJ CJ CJ CJ CJ CJ CJ CJ O t o z J CJ f o o z cj υ O O CO Z O O O O CJ O υ o o u o z O CJ o o ιn w ι inn iιn CM CM CM CM

2222222222222222222222222222222222222222222222222222222 o EHoEHoEHoEHoEHoEHoEHoHoHoEHoEHoEHoEHoHoEHoEHoEHoEHoEHoHoHoHoEHoEHoEHoHoH EoHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoEHoEHoEHoEH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

O

(Tι co o vo t~ ^,o cM C co cn cn r- cn cn co cM co co o oo cn 'tf r-- ri r-- ιn ri ri o cD co r~ oo cn oo co o rH oo oo co r-- r- oo cn "tf θ r-- m oo o oo oD ro cM OD oo oo oo oo oO 'tf m m oooooooooooooooo oooooooooooooooo

'tf i" oo cn ιn ^ cn oo cn o ιn o crι o r- ^, > oo rH θo cM oo r-- r-- ι-H CM θ ri rH in oo oo r-- co ιθ rH cτι r~ ri co ^r ιn σι oo ιn oo r- ri ri co ri cn ιn o i' ri ιH in ιH CM θ ∞ ri 'tf c ιH 'tf r-~ ι c r-- c ιjo <θ rH ιH θ ^ ro cn cn ιⁿ co cM r-- θ "tf r--

_O CO 'T OO r_^ 'tf O rH in oO OO CO rl CM en CO CM CO -^ rO Ln CM -^r CD rl lXl r O rl CO rl rl m m c~- o cn ιn cM co m "tf rH r- oo o o co ri co co ro o ιn rH i ι_H θ o σ^ oo co o _θ ri CM _CM CM c oo oo oθ '_tf "tf in "tf ^r co ιn co co ιn r-- r- co oo oo cn CM 00 CM CM CO i> "tf m m ^o r- r- r— r- o o o o o o cn αo oo o o o o o o o o o o o o o o o o o o o o o o o o o o rl rl rl rl rl ιo i£i N ω σι oo r- O H

^c oo (ϊ) ^■ o^ Λ <Jl O -) ι^ (M H (D O H (^l <!ι o α) ^ ιfι ιn <J n ■» (Il co ω ^ oo co ^ ^ ^D co ^ ol (Jl o ^ ^ ^!l ι 1^, (^,) co m m vo io r- oo o ri ^ ^ '^ ^ ^ji '^ ^ Lθ "tf in ιn ι ι ιn ι ιn "tf i 'i' "tf 'tf 'r 'tf "tf 'tf "tf _"tf 'tf "tf ^,tf 'tf ^ "tf "tf 'iⁱ "tf 'tf ^ ιn "tf "tf 'J^ι "tf «tf ^ "tf 'tf '^ 'J' 1' "tf "tf L L o u ou

N N H ιη r~ r~ co cn oo r- co r-. co cn cn cn oo cn cn cΛ cri c

cM CM CM CM co oo o r c o oθ ' 'r ^ "tf 'r ^ "tf in ι ιn ιn ιn ι ιn ι ιn cD Cβ <Λ i" io ιo co r^

C» 00 C0 00 00 00 00 00 00 CD CO 00 O0 00 CO CO CO CO 00 0D a0 00 00 C0 C0 00 00 00 ∞ CO CO 00 00 CO CO CO C» 00 ∞ ∞ o o cj υ υo o cj o o υoo o υ o o υ o cj u cj o υ u o υ u cj υ cj o o υ u o u o υ υ cj ucj oo cj o c υu cj cj cj o x os oS os os os oS oS O O O O O O O Z Z Z Z Z Z Z Z Z O O O O O O O OS QS OS PS PS OS PS D D D D D D D D D CCJJ CCJ OJ CCJJ CJJ CJJ > ι a a a a a a a oS PS on oS oS oS cj c cj aiHi HaH Ha π i^ HaHa Ha pS oS cS P pS oS Pϋ a a a a w ωω ω ωω ω cxi oή P ps psps os CLι θ cj c cj c cj c o iι CL, c c αH Cχι C-ι EH EH EH EH EH EH eH H Ha Ha Ha Ha Ha Ha H tf tf tf tf tf tf rl CM CM CM tf tf O CJ J Q tf CO CJ J Q Cxl Cxl D tf CQ CJ tf CQ CJ CJ tf CQ CJ Q Q tf CQ CJ Q Cxl

Z U J O Z c υ o cj u o CJ J J J J o z tf CQ

CJ O O J o z CJ O Z CJ U CJ CJ CJ o z υ υ o υ u o z υ υ cj u u u z cj u o cj z

O H ⁽ n ^ l ιo ^ oo o o H ι n "J ιn w ^ ι^) (Λ O H N ( ^ ι ω ^ ra m o H N (^,^ ^ ι ^o ^ » s^ O H N n Hf ι ιD oD m o H (^ι (η ^ oo oo eo co oo co co oo co oo oo ro oo c c co oo oo oo oo oo oo co oo oo n ro oo oo oD OD oD ro oo o oo n

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

2oo22o2oo2o22o2oo2o2o22o 2o o22 EHo2 EH EHo22 EHo2 EH EoH EHo2 EHo2 Ho2 HoEHo22 2 222o2o222222222222

EH EH H H EH EH EH H H EH EH EHo2 EHo2 HoEHo2 EHoHo22 EHoHo22 22 HoEHo2 Ho2 HoEHoHo2 Ho22 HoEHoHoEHoEH H EHoHoEHoEHoEHoEHoEHoEHoHoEHoHoEH o tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

ι^ c ΓO o o lO N M o cn co r~ r- co r- co oo oo en oo r— ιo r~ t~ u> ιn ^ ιn θ ι-H θ ι-H ιH θ θ ι-H M CM θ 'tf in ii> r~ oo c ιn ιo ιn ιn ιo r- vo oo ιn o ^ o ^ r ιn ι r^ ιn "tf in ^ rl rl rl rl rl rl rl rl rl rl rH iH rl iH i-H rH iH CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ iH iH rl rl iH iH iH rH iH rl rH iH rl iH iH rl rH rH rH i-H iH i-H i-H iH rl rH iH iH rH iH rH iH rH rH rH iH i-H rl iH iH iH co r- ι* "tf θ r~ ri o o H H tτi H ^ ra o n N θ ^ rH σi (!i h o oo D "j N co r- M σι «! N σi N ^ ^ o o t i£⁾ m o n (θ N in ι τr ι ιn (^,ι r- "tf cn oo cM O -=r m oo en oo o o c co r cΛ σ^ ^ "tf ι-H «tf ιH ι-H i ^ ι-H θ c ιo kD o σι o ιn o o cn r-- ι "tf "tf ^ ri ∞ ^ o r^ oo o3 θ θ ri

"tf oo ro cn M "tf θ ιn ^, > (η H I in iO ^ r^ N OO i ffl ffl l O ^ tD i tD W O rl O tf Λ h m oi lD N ^ W f N in Ol f tf in Ol ^ H H O

^^ι M n ιn ιfl ι ιΛ n ^ι N H C^l N H O H O ι w ι ω ^ oo o o^ ι ιn ιn f O^ (η N H H ι » ιn ^c u ι ^ ^ ffl m ω w o H <S (Jι σl σι (Io σι σl ιn ι ιn "tf "tf 'tf 'tf "tf ^f* "tf "tf 'r ^ 'i^ι 'i^, ^ "tf ^ 'tf "tf "tf *tf ^^ Lθ 'tf 'f 'tf "tf 'tf 'tf "tf ^ 'tf 'tf 'tf ^ ^ "tf "tf ^ '^ ι "tf 'r "^

^ 0 (^l fⁿ ιn co ι^,1 ^ ιo ^ p• ^ H σι ιn N co H H ^ι' o ι o 'f ^ "J' Φ O H O lD r- (^) o ιD o o o3 ri ln N (^,1 (l ^ σ> ι ιη ιo c'l liι ^ H H

O lO M OI O O H n H H in H ^ ri in tM Ol O O H ^ ID O M O OK fl lO Ol OO IΛ IΛ O O N rΗ O in t O IΛ H in lO N tO l/l O N r Hj n m m ol (!^ o m ω ιn ^B ι o H ^ "^ N ιn ω ιη o^ o ιn ffι ω ol H ιn ^ ^ ^~ ^ ιn "^ ^ ^ <^ι v tfl ^B 'i^ o o ^ l co rl ^ (!^ o ι^r^ ι'l ι ι^τ) ^ ιn

Ol Ol Ol lIl Ol O O O O O O O O O O O O O O ri H H ri ri H H H N N N N t N N t IM tn fl l'i n n in Ci n fl' ^ Hr l' in Kl in in ilHO ΪI

<x> co o^ o^ cD cn c cn cΛ c <^ι < α <7> n c cn cn c c σϊ cn σ> σ c cn σι c cn cn c cn σ> σ Λ c^ ri ri d ri H H H H H H H H H H H H H H H H H rt ri ri H H H H H H H H H H H H H H H H rt H ri H H H rl rl H H H H rl H H υuυocjooocjoυouooooυcjcjυυcjcjυυouυυcjoυocju o υ υ o u υ o υ o cj υ o CJ J o J υ o o

U O CJ U U ⁽- CI< ⁽- ftι (. Bι ⁽- Clι ⁽- (lι ll( |lι (- |lι D D D D D D D S tn n θ) W t O) 01 t(Hn z z z z z z z z x x x x O co co CO CO D O pS 0S Cή (-S C-; pS P≤ pS PS C-S α; pS pS C-5 pS θS 0S 0S 0S t^χl C^χl C^χl C^χl C^χl W C^χl t^χl X X X X X X X X X co o co c c co co co i-a Ha H Ha X X X X X HJ H!

⁽C ^pC iaK flj H ti EH fH EH tH H H tH tH H tH BH ^i a Hi ia a j a i iJ Hi J Hi ia a j ii j tf tf tf tf tf tf tf tf CJ CJ O CJ H! i-a HI Hi i-a c CJ rH CM rl CM rl CM co a a tf cQ c α cxi ω α cxi co co a tf CO CJ Q Q tf CO CJ Q Cxl CO tf CO CJ Q Q z o o tf υ z tf CQ tf

Z U CJ CJ CJ CJ CJ CJ Z CJ CJ U CJ O u υ o υ υ o o Z CJ O O U O Z CJ O Z O O CJ O Z CJ O Z O O O z J J o o z J ιn w ^ co o o H ^l ιη "I ιn w ^ ra m o H < ⁽D ^ ιn vo ^ ω σι O H (ι ^^ ^ ι ^o oo tI O H ^ι ι») ^ ιn ^o ω <J O r^ N M '» ιn ιo ^ ro c^!l ^lD ^l^⁾ ^B ^D ^o ^ r- r^• ^ ^ ^ ^ ^ t-^■ ^ ⁽o co ffi co oo oo oo αl 03 t^) ⁽Iι αl ⁽Jl ⁽Jl ⁽Λ m o^ ⁽!l tn σl o o o o o o o o o o H H H H H r^ H H H H oo oo oo oo co ro oo co oo ro co co oo co oo co oo ro oD oo oo co oo oo eo oo oo oo ro eo oo oo oo ro oO 'r

CM CM CM C CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

o22 H Ho2222222222 EoH EoH EoHoH EoH EoHoH EoHoH EoH

o "tf θo M ^o M θ ri co ro cθ "tf CM r~ i- ri c ^r o_ o _ CM CM rl r^ o cM CJ^ o σi 'tf oo o oo in o oo c co 'tf oo o co 'tf CM oo cM CM o r- 'tf in ri o 'tf ri oo r- oo r~ CM r^ cM c ri o cn ιθ ri 'q< o ro o σι o cθ Ln r- ιo ιn oo c "tf in cM Ln ιn ro cn oo o o ιo ι 'tf in co r- co ιθ 'r r-- CM r- CM ro cn rH θ δ oo o o ri cn oo r~ cn ιo cn ιn cM ri oo "tf M in r^ r~ r- *o - co σi crι crv in oo co oo o co ^«tf m m 'τ ιo m -tf co ^ r^ o σ ^-• r-- "tf ^~- c ^■tf CM o

00 "tf -tf p r to o on o tD iη ^ ^ f "t_f ^^ι τ "t_f 't_f 'r ι^l 'tf "tf ^ "t_f 'tf "tf ιn ιn ιn ιn "tf 'r 'r "tf 3' "tf "tf ι> ^ τ ^r o o o o ro o "tf tp oooooooooooooooooooooooooo ooooooooooooooooooooooooooo o o oooooooooooooooooooooooooo ooooooooooooooooooooooooooo o o

H U

AH (ι ιn ^n n ^ O ι N O ω ι H ^ H N » H lfi H^ H ι ι o^ c^l "l' n ι m ^ w oo ( ^n o cD co lfl ^o ^ N O Ol ^ι t^ o O rl ^•Hf O t^ ^ι ^ o in o r^ O 'r cO 'r r^ co o 'tf co c O CM i cM ^ co ∞ oo cM in i c co cM 'tf oo ^ c co o cM O M in c cM C^ rl fl' ιn ^) O H ιfl ιn ∞ ol ι cι o O H H H ιn ^^ o o 'J ιn tD ι ^ H ^• H (Jι α) (D O O ιn ιn ιfl O O H ^ (» ιπ « ι-■ ^l (^,^ o ^!! ιn ol co co H ιn m ι 'tf m r «tf oo ιn ro ιo ιn ιn ι^, co ιo r~ co r r-~- ccoo uιno cιoo mιn mιn rr~~ ccoo oooo oo oo o co o o cM θ o oo cn o cn cri cn o ι-H θ o cn oo r~ r~ r~ ^,£> r-- o o

CM CM ( N r tM N N N N N N (NI N N ( N N N CM (CM ^ΛCM^{1 Λ}CM^{1 Λ}CM^{I Λ}CM^I ™CM ™CM ~CM ^mn 'c"O C CM OO OO n n OO CM CM CO CM CM CM CO OO CO OO CM CM CM CM CM CM CM CO OO oo oo in cM O ri o r- CM Co o cM i' r- in ri io cM rH "tf n 5 ιH σι M co oo ιH M Ln r~ "tf θ ^ ^ ^ o ra cn rH "^ 'tf Ln ^ "tf C ^ D ri M r~ 'tf vo cn

CM O C0 rH 00 ' > C0 "tf CO CM r0 CD in r~ rH r-- 00 i-H r~ C i cn io oo cM CM co c co "tf r~ o io o^ "tf r~ co "tf n "tf UD M t^ o c in o oo "tf r~ co co «tf r-- o r- -ri' VO C ' O O co r- o po O c co c co LO ■H ^ ∞ iH in ^ oo r^ c^ 'tf O CM yJ co 'r o cM O in i o o r- σi o oo Ln cM J i in r- 'tf 'tf Ln r~ r- o in o o 'tf oo o cn O OO 00 o o rl O O O rl l CM OO "tf "tf LO m en co r~ r- ^|i> co in i^, co eo co io

-tf "tf ^•^r "tf "tf "tf _"tf "tf 'tf ^ oo oo ^■sr "tf ^r "tf »tf ^p oo oo oo oo oo oo oo oo oo co co co

<» ιn Φ n N ^ m ^ fn ^ <l' to N H ^ (Il o H (» fl (^ι ^ o oo H n ι ^,β '!f ^ ^ <Jl co cΛ M oo ιn cM ri cn co cn r~ ιnιncoc m_"tf 'tf 'tf *⁰ ι _"tf 'tf in ro r-~ oo cn cri cn cn cn cn crι cn

l0 ll⁾ r- M- r^,- t M^ r' M^ M0 (0 ffi (0 l!0 (Λ 01 5101 (Λ irι O O O O O O O O H H H H ri H H H H ri fl (M N M N (M N ( N M (M

^ cn <τ» cn cn cn cn cn cn cn cn σι σι cn cn cn cn cn cn cn cn cn cn cn cn cn o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o υ u υ υ o υ υ υ u υ o o υ o υ υ c^j u c u o υ cj υ o υ c υ υ υ u u cj u u u υ u cj υ υ c u o υ c c u o o υ o o u

D D co co co co co O_ O_ O_ O_ O_ O_ O_ C-ι C-) C-ι C-ι C aι C-ι l--ι C0 C0 O co co O CO CO CO CO CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ

X X X X X oS oS oS pS oS oS oS co co co co co co co c ri i-H H H H H OS pS oS oS O o

C3 0 CJ CLI CXI C-. C-I CLI (-J C-I C-I C-I C-I CLI Ha Ha H Ha Ha a< -ι -ι : c ι_l CL₁ tf tf tf tf tf tf tf tf a a a a a aaaatftftftftfS ptfS otfS αtfS PtfS otfStfS rl CM rl CM CM rl rl CM co tf CQ CJ Q Q Cxl W cO tf CQ Q tf CO CJ tf CO CJ Q Q tf CQ CJ O Q Cx] Cxl CO CJ Q Cxl CO j o o z o cj υ u cj u cj oυo z c u υ z cj o o u υ o z c CJ υ o o CJ o Z CJ O O CJ Z CJ Z υ o z u uu zu a z a z cj o θ (η <j

CM

■f P Hr

CM

0 2222 22 22 2 2 22 22 22 r0H o o o o o o O O O O O O O o O O O O SS H H tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o O

Table 1

ATOM 2475 N ILE C 203 97. 359 35. 524 131. 772 1. 00 42. 53

ATOM 2476 CA ILE c 203 98. 311 34. 430 131. 958 1. 00 44. 52

ATOM 2477 CB ILE c 203 97. 821 33. 391 133. 016 1. 00 45. 70

ATOM 2478 CG2 ILE c 203 98. 781 32. 199 133. 078 1. 00 45. 54

ATOM 2479 CGI ILE c 203 97. 776 34. 034 134. 403 1. 00 48. 01

ATOM 2480 CDl ILE c 203 99. 143 34. 427 134. 944 1. 00 48. 44

ATOM 2481 C ILE c 203 98. 539 33. ,703 130. 638 1. 00 44. 37

ATOM 2482 O ILE c 203 97. ,593 33. 443 129. 888 1. 00 45. 23

ATOM 2483 N GLY c 204 99. 796 33. ,374 130. 358 1. 00 43. 64

ATOM 2484 CA GLY c 204 100. .115 32. ,691 129. 118 1. ,00 42. ,70

ATOM 2485 C GLY c 204 100. 151 33. ,673 127. 964 1. 00 41. ,41

ATOM 2486 O GLY c 204 100. .620 33. .346 126. 881 1. ,00 40. ,04

ATOM 2487 N GLY c 205 99. ,643 34. ,880 128. 208 1. ,00 41. ,20

ATOM 2488 CA GLY c 205 99. ,614 35. .913 127. ,187 1. ,00 40. ,95

ATOM 2489 C GLY c 205 98. ,808 35. .575 125. ,942 1. ,00 40. ,36

ATOM 2490 O GLY c 205 97. ,720 34. ,998 126. ,017 1. ,00 40. ,49

ATOM 2491 N TYR c 206 99. ,347 35. .947 124. ,788 1. .00 39. ,57

ATOM 2492 CA TYR c 206 98. .691 35. .683 123. .515 1. .00 38. .69

ATOM 2493 CB TYR c 206 97. .467 36. .589 123. .351 1. .00 38. .68

ATOM 2494 CG TYR c 206 97. .801 38. .060 123. ,281 1. .00 38. .74

ATOM 2495 CDl TYR c 206 97. .668 38, .872 124. ,401 1, .00 39. .11

ATOM 2496 CE1 TYR c 206 97. .957 40, .217 124. .339 1. .00 39. ,50

ATOM 2497 CD2 TYR c 206 98. ,243 38. .640 122. .091 1, .00 36, .73

ATOM 2498 CE2 TYR c 206 98. .538 39. ,973 122. .022 1, .00 37, .36

ATOM 2499 CZ TYR c 206 98. .393 40. ,761 123, ,148 1, .00 40, .01

ATOM 2500 OH TYR c 206 98. .697 42. .101 123. ,097 1, .00 43, .16

ATOM 2501 C TYR c 206 99. .645 35. .889 122, .340 1, .00 37. .30

ATOM 2502 0 TYR c 206 100. .583 36. .671 122, .431 1, .00 38. .54

ATOM 2503 N LYS c 207 99. ,392 35. ,194 121, ,234 1. .00 36. .45

ATOM 2504 CA LYS c 207 100. ,237 35. .300 120, ,046 1, .00 36. .87

ATOM 2505 CB LYS c 207 100. .591 33, ,907 119. ,504 1. .00 32, .85

ATOM 2506 C LYS c 207 99. .576 36, .098 118. .934 1, .00 37. .95

ATOM 2507 O LYS c 207 98. ,397 35. .915 118. .639 1. .00 38. .31

ATOM 2508 N VAL c 208 100. .349 36, .981 118. .313 1. .00 40, .05

ATOM 2509 CA VAL c 208 99. ,850 37, .796 117. .207 1. .00 41, .07

ATOM 2510 CB VAL c 208 100. ,060 39. .307 117. .460 1, .00 38. .91

ATOM 2511 CGI VAL c 208 99. ,653 40, .100 116, .237 1. .00 38, .42

ATOM 2512 CG2 VAL c 208 99. ,241 39, .^•748 118, .642 1, .00 40, .22

ATOM 2513 C VAL c 208 100. ,572 37. .437 115, .910 1. .00 42, .48

ATOM 2514 O VAL c 208 101. .672 37, .921 115, .663 1 .00 43, .10

ATOM 2515 N ARG c 209 99. .971 36, .577 115, .089 1, .00 44, .16

ATOM 2516 CA ARG c 209 100. .587 36, .204 113, .811 1, .00 45, .44

ATOM 2517 CB ARG c 209 100, .056 34, .853 113, .305 1 .00 43 .55

ATOM 2518 C ARG c 209 100, .231 37, .313 112, .816 1 .00 46, .48

ATOM 2519 O ARG c 209 99. .090 37 .393 112, .346 1 .00 46, .30

ATOM 2520 N TYR c 210 101. .210 38, .169 112, .512 1 .00 46, .88

ATOM 2521 CA TYR c 210 101. .003 39 .299 111, .605 1 .00 46 .66

ATOM 2522 CB TYR c 210 102. .192 40 .265 111, .627 1 .00 49 .05

ATOM 2523 CG TYR c 210 102, .532 40, .780 113 .008 1 .00 54 .11

ATOM 2524 CDl TYR c 210 103. .331 40 .028 113 .876 1 .00 56 .13

ATOM 2525 CE1 TYR c 210 103, .602 40 .468 115 .170 1 .00 57 .60

ATOM 2526 CD2 TYR c 210 102 .013 41 .997 113 .473 1 .00 55 .77

ATOM 2527 CE2 TYR c 210 102. .275 42 .447 114 .765 1 .00 57 .07

ATOM 2528 CZ TYR c 210 103. .069 41. .676 115 .608 1 .00 58 .31

ATOM 2529 OH TYR c 210 103. .321 42, .107 116 .892 1 .00 60, .81 Table 1

ATOM 2530 c TYR C 210 100. 768 38. 868 110. 191 1. 00 44. 74

ATOM 2531 O TYR C 210 100. 074 39. 547 109. 441 1. 00 45. 31

ATOM 2532 N ALA C 211 101. 361 37. 744 109. 818 1. 00 43. 76

ATOM 2533 CA ALA C 211 101. 194 37. 231 108. 471 1. 00 43. ,74

ATOM 2534 CB ALA C 211 102. 120 36. 057 108. 252 1. 00 43. ,87

ATOM 2535 C ALA C 211 99. 740 36. 812 108. 266 1. 00 43. ,16

ATOM 2536 O ALA c 211 99. 255 36. 747 107. 144 1. 00 42. ,29

ATOM 2537 N THR c 212 99. 052 36. ,548 109. 370 1. ,00 44. ,47

ATOM 2538 CA THR c 212 97. 652 36. 126 109. 351 1. ,00 45. ,66

ATOM 2539 CB THR c 212 97. 380 34. ,968 110. 343 1. ,00 48. ,23

ATOM 2540 OG1 THR c 212 98. ,597 34. ,273 110. ,634 1. ,00 52. ,50

ATOM 2541 CG2 THR c 212 96. 351 34. 000 109. 770 1. 00 49. ,52

ATOM 2542 C THR c 212 96. 712 37. 246 109. 780 1. 00 44. ,59

ATOM 2543 O THR c 212 95. 491 37. 092 109. 704 1. ,00 45. ,13

ATOM 2544 N TRP c 213 97. 268 38. 352 110. 263 1. ,00 42. ,58

ATOM 2545 CA TRP c 213 96. 436 39. ,456 110. 703 1. ,00 40. ,90

ATOM 2546 CB TRP c 213 95. ,598 39. ,986 109. 537 1. ,00 42. ,74

ATOM 2547 CG TRP c 213 96. ,411 40. ,547 108. ,437 1. ,00 42, .12

ATOM 2548 CD2 TRP c 213 97. ,005 41. ,842 108. ,402 1. ,00 41. .92

ATOM 2549 CE2 TRP c 213 97. ,714 41. ,942 107. ,187 1. ,00 42. .84

ATOM 2550 CE3 TRP c 213 97. ,007 42. ,934 109. ,281 1. ,00 41. .10

ATOM 2551 CDl TRP c 213 96. ,767 39. .924 107. ,281 1. .00 42. ,59

ATOM 2552 NE1 TRP c 213 97. ,552 40, .756 106. ,521 1. .00 43. ,69

ATOM 2553 CZ2 TRP c 213 98. ,421 43. .089 106. ,824 1. .00 43, ,35

ATOM 2554 CZ3 TRP c 213 97. .705 44. .075 108. ,925 1. .00 42, ,32

ATOM 2555 CH2 TRP c 213 98. .405 44. .145 107, .704 1, .00 43. .55

ATOM 2556 C TRP c 213 95. .508 38. .954 111. .788 1, .00 39. .39

ATOM 2557 O TRP c 213 94, ,321 39. .294 111. .817 1. .00 38. .02

ATOM 2558 N SER c 214 96. ,040 38, .138 112. .684 1, .00 38. .04

ATOM 2559 CA SER c 214 95. .195 37. .612 113. .735 1. .00 38. .52

ATOM 2560 CB SER c 214 94. .704 36. .209 113, .366 1, .00 38, .63

ATOM 2561 OG SER c 214 95. .787 35, ,308 113, .243 1, .00 40, .15

ATOM 2562 C SER c 214 95. .831 37, .588 115. .109 1, .00 37, .44

ATOM 2563 O SER c 214 97. .045 37, .753 115. .254 1. .00 38, .93

ATOM 2564 N ILE c 215 94. .981 37, .411 116. .116 1. .00 34, .80

ATOM 2565 CA ILE c 215 95, .423 37. .335 117. .497 1. .00 32, .54

ATOM 2566 CB ILE c 215 94, .881 38, .482 118. .343 1, .00 30, .76

ATOM 2567 CG2 ILE c 215 93, .351 38. .494 118. .285 1. .00 27, .37

ATOM 2568 CGI ILE c 215 95, .424 38, .341 119. .765 1, .00 29, .21

ATOM 2569 CDl ILE c 215 95, .232 39, .566 120. .634 1, .00 31, .69

ATOM 2570 C ILE c 215 94, .872 36, .034 118, .044 1, .00 32 .55

ATOM 2571 O ILE c 215 93, .739 35 .654 117, .753 1, .00 32 .98

ATOM 2572 N ILE c 216 95. .670 35 .347 118, .843 1, .00 30 .59

ATOM 2573 CA ILE c 216 95 .235 34 .079 119, .385 1, .00 27 .26

ATOM 2574 CB ILE c 216 96 .011 32 .945 118 .732 1, .00 27 .82

ATOM 2575 CG2 ILE c 216 95 .489 31 .617 119, .218 1, .00 26 .00

ATOM 2576 CGI ILE c 216 95 .889 33 .072 117 .210 1, .00 30 .26

ATOM 2577 CDl ILE c 216 96 .663 32 .040 116 .427 1 .00 32 .20

ATOM 2578 C ILE c 216 95 .389 33 .985 120 .882 1 .00 25 .63

ATOM 2579 O ILE c 216 96 .407 34 .373 121 .444 1 .00 24 .12

ATOM 2580 N MET c 217 94 .357 33 .482 121 .533 1 .00 25 .01

ATOM 2581 CA MET c 217 94 .405 33 .312 122 .968 1 .00 26 .49

ATOM 2582 CB MET c 217 93 .450 34 .270 123 .668 1 .00 25 .10

ATOM 2583 CG MET c 217 93 .780 35 .714 123, .453 1, .00 26, .08

ATOM 2584 SD MET c 217 92 .719 36 .763 124, .435 1, .00 28, .69 Table 1

ATOM 2585 CE MET C 217 91. 386 36. 979 123. 321 1. 00 29. 90

ATOM 2586 C MET C 217 94. 076 31. 869 123. 333 1. 00 28. 23

ATOM 2587 O MET C 217 93. 113 31. 271 122. 843 1. 00 28. 32

ATOM 2588 N ASP C 218 94. 910 31. 300 124. 190 1. 00 29. 55

ATOM 2589 CA ASP c 218 94. 711 29. 935 124. 632 1. 00 28. 10

ATOM 2590 CB ASP c 218 96. 044 29. 248 124. 890 1. 00 26. 11

ATOM 2591 CG ASP c 218 96. 745 28. 854 123. 626 1. 00 27. 42

ATOM 2592 OD1 ASP c 218 96. 054 28. 374 122. 698 1. 00 25. 60

ATOM 2593 OD2 ASP c 218 97. 991 29. 006 123. 570 1. 00 30. 13

ATOM 2594 C ASP c 218 93. 894 29. 944 125. 912 1. 00 28. 61

ATOM 2595 O ASP c 218 93. 813 30. 969 126. 595 1. 00 27. 04

ATOM 2596 N SER c 219 93. 297 28. 793 126. ,224 1. ,00 29. 67

ATOM 2597 CA SER c 219 92. 480 28. 607 127. ,425 1. ,00 29. 41

ATOM 2598 CB SER c 219 93. 314 27. 972 128. ,534 1. ,00 29. 13

ATOM 2599 OG SER c 219 92. 485 27. 653 129. ,642 1. ,00 30. 01

ATOM 2600 C SER c 219 91. 818 29. 873 127. .972 1. .00 29. ,79

ATOM 2601 O SER c 219 92. 176 30. 372 129. ,041 1. ,00 27. 97

ATOM 2602 N VAL c 220 90. 829 30. 374 127. .239 1. .00 31. ,22

ATOM 2603 CA VAL c 220 90. .109 31. ,577 127, .631 1. .00 30. ,62

ATOM 2604 CB VAL c 220 89. .239 32. 075 126. .481 1. .00 27. ,62

ATOM 2605 CGI VAL c 220 90. .109 32. ,616 125. .378 1, .00 26. ,20

ATOM 2606 CG2 VAL c 220 88. .413 30. ,946 125. .956 1. .00 29. ,75

ATOM 2607 C VAL c 220 89. .235 31. .393 128, .870 1, .00 31, .94

ATOM 2608 O VAL c 220 88. .472 30. ,434 128. .994 1. ,00 32. ,79

ATOM 2609 N VAL c 221 89. .353 32. ,334 129. .791 1. .00 32. .13

ATOM 2610 CA VAL c 221 88, .586 32. .293 131. .022 1. .00 31, .92

ATOM 2611 CB VAL c 221 89. ,533 32. .287 132. .267 1, .00 31. .72

ATOM 2612 CGI VAL c 221 90, ,534 31, .137 132. .175 1. .00 29. .53

ATOM 2613 CG2 VAL c 221 90, ,269 33. .608 132. .365 1. ,00 31, .11

ATOM 2614 C VAL c 221 87. .682 33, ,537 131. .046 1, .00 32, ,11

ATOM 2615 O VAL c 221 87, .858 34. .446 130, .229 1, .00 31. .15

ATOM 2616 N PRO c 222 86, .707 33. .597 131, .982 1, .00 31. .23

ATOM 2617 CD PRO c 222 86, .345 32. .563 132, .966 1 .00 30. .92

ATOM 2618 CA PRO c 222 85, .784 34, .731 132, .105 1, .00 30. .47

ATOM 2619 CB PRO c 222 85 .070 34, .457 133, .419 1 .00 27. .58

ATOM 2620 CG PRO c 222 84 .953 33, .014 133, .399 1, .00 29. .80

ATOM 2621 C PRO c 222 86 .424 36, .114 132 .096 1 .00 31. .43

ATOM 2622 O PRO c 222 85 .848 37 .055 131 .548 1 .00 30. .86

ATOM 2623 N SER c 223 87 .598 36, .255 132 .711 1 .00 32. .22

ATOM 2624 CA SER c 223 88 .256 37 .560 132 .730 1 .00 31 .94

ATOM 2625 CB SER c 223 89 .503 37, .548 133 .644 1 .00 31, .67

ATOM 2626 OG SER c 223 90 .516 36 .649 133 .212 1 .00 30 .71

ATOM 2627 C SER c 223 88 .619 38 .009 131 .305 1 .00 32, .23

ATOM 2628 O SER c 223 88 .892 39 .179 131 .070 1 .00 31, .36

ATOM 2629 N ASP c 224 88 .609 37 .078 130 .357 1 .00 31 .98

ATOM 2630 CA ASP c 224 88 .912 37 .412 128 .978 1 .00 32, .72

ATOM 2631 CB ASP c 224 89 .340 36 .169 .128 .201 1 .00 35 .56

ATOM 2632 CG ASP c 224 90 .740 35 .736 128 .537 1 .00 37 .51

ATOM 2633 OD1 ASP c 224 91 .622 36 .618 128 .591 1 .00 40 .81

ATOM 2634 OD2 ASP c 224 90 .964 34 .525 128 .736 1 .00 37, .64

ATOM 2635 C ASP c 224 87 .691 38 .002 128 .312 1 .00 32 .18

ATOM 2636 O ASP c 224 87 .799 38 .675 127 .298 1 .00 32 .48

ATOM 2637 N LYS c 225 86 .521 37 .725 128 .872 1 .00 31, .98

ATOM 2638 CA LYS c 225 85 .277 38 .234 128 .315 1 .00 32, .69

ATOM 2639 CB LYS c 225 84 .128 38 .037 129 .314 1 .00 33, .13 O o

O O

O 'tf ri co r- ri "tf oo o itf oo vo c o co r- rl CM Cn so so CO SO en o o rl rl o OO 00 ^r -tf oo in oo ■tf OO OO rl l-H O o o σι o θ 'tf in ι^ r^ r~ ιn ι Ln ιn co r~- 'tf "rjι r-- oo cn o c o oo o oo oo r-- c m 00 00 o 00 •^r ^ ^r "tf "tf ^^ *cy * * ^^ ^3^ ^«ζj^ ^ * ^ ^ * ^3* ^* ^^ι 'tf θ θ 'T ^,tf "tf 'tf 'tf 'tf 'J¹ "tf "tf 'r 'i^l "tf "tf "tf "tf ^r "tf 'j Ln 'ϊ^ι m "tf "tf "tf 'tf "tf 'tf ln o ^O (^,l ln N O ^Iι u^ ^^ ^ (^,l ln "l^, H H co ιn 1^| ι (Il n M H {η ρ- o ω σ> "» w o σ) v ιn

(η ^^ H O ιn ιn ^f ιn ιn "^' ι ιn ^ ( N t^| ι^> ^ ^ oo Λ (Jl ra flo o o cil (Jι co (!l lI o ^ m o H O H H O H O (^,^ (η lη ■» ^ ι ^ι ^ ιn ^ ^ ^| ιn oo oo oo oo oo oo oo oo oo oo oo oo oo oo oo oo ∞ co cD OO CD Oo oo oo cn oo ∞ ∞ oo co oo co oo co ∞ cn cn cn cn en cn en c^

ιn i0 ιn in in in ^ l0 ^ Φ ^ t~ ^ h ^ ^ C0 05 (D C0 ∞ 00 ffi 0 C0 00 (D CD σι 01 Λ (Jl ()1 5i ai O O O O O O H rl H H H rl H H (\I M rv| IN|

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM ( CM C CM CM CM CM CM C CM C 00 0 rO 0 M

CM CM CM C CM CM CM CM CM CM CM CM CM CM CM C CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ υ o u u υ u υ υ υ υ u cj o o o o cj u cj υ υ u c c υ c u o u o u o o o o o cj u cj c o u u u u o υ υ υ υ c cj c υ υ co co co co co co x x x x z z z z z z z z P≤ DS oS oS oS pή oS oS oS OS OS OS OS oS oS oS oS p≤ OS CO CO CO CO CO CO Cxl Cxl Cxl Cxl Cxl Cxi ω Cxl x x x x X x ►i i H i tn ω o w ω c w X X X X X X X X X X X X X X X X π π ι-a πa π H! tf tf tf tf >- tl >ι >ι ι CJ CJ CJ CJ tf tf tf tf tf tf tf tf υ υ u υ CJ υ

CM rl rl tf CO CJ Q Q tf CQ CJ Q Cxl Q Cxl co a tf CQ CJ CJ t CQ CJ tf CO CJ CJ Q tf to cj j υ u z cj o .z cj υ o z υ υ cj o z o o z CJ CJ CJ U CJ CJ CJ CJ O CJ O Z CJ CJ O CJ O o zf

O CJ O O CO o CJ CJ CJ cj υ Z J O CJ

o 22oo22oo2o2o2o22oo22oo22oo2o22o2oo22o2oo22o2o2oo22o2 2

© oo2o22oo2o2oo22oo22oo22o2oo2o22oo2o22oo22o2oo2o22oo22oo2 o tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

Cable 1

ATOM 2695 CG2 VAL C 232 93. 887 45. 966 110. 174 1. 00 31. 80

ATOM 2696 C VAL c 232 95. 174 49. 498 110. 184 1. 00 37. 27

ATOM 2697 O VAL c 232 94. 204 50. 168 109. 831 1. 00 37. 78

ATOM 2698 N GLU c 233 96. 413 49. 945 110. 094 1. 00 39. 96

ATOM 2699 CA GLU c 233 96. 627 51. 299 109. 626 1. 00 41. 82

ATOM 2700 CB GLU c 233 96. 523 52. 239 110. 825 1. 00 42. 88

ATOM 2701 CG GLU c 233 96. 386 53. 679 110. 443 1. 00 48. 56

ATOM 2702 CD GLU c 233 96. 259 54. ,578 111. 642 1. 00 51. 10

ATOM 2703 OE1 GLU c 233 96. 017 54. ,054 112. 756 1. 00 52. 31

ATOM 2704 OE2 GLU c 233 96. 393 55. ,810 111. 457 1. ,00 53. 25

ATOM 2705 C GLU c 233 97. 930 51. .572 108. 876 1. ,00 40. 67

ATOM 2706 O GLU c 233 98. ,935 50. ,889 109. ,076 1. ,00 40. 71

ATOM 2707 N ASN c 234 97. 879 52. ,567 107. 994 1. 00 39. 72

ATOM 2708 CA ASN c 234 99. 038 53. ,019 107. 234 1. ,00 39. 29

ATOM 2709 CB ASN c 234 99. 203 52. ,272 105. 884 1. ,00 36. 35

ATOM 2710 CG ASN c 234 98. 347 52. .840 104. ,748 1. ,00 35. 20

ATOM 2711 OD1 ASN c 234 97. ,750 53, .905 104. ,859 1. ,00 33. ,07

ATOM 2712 ND2 ASN c 234 98. ,308 52. .115 103. ,631 1, .00 32. ,78

ATOM 2713 C ASN c 234 98. ,869 54. .523 107. ,039 1, ,00 40. ,78

ATOM 2714 O ASN c 234 97. .893 55. .102 107. .524 1. ,00 40. ,10

ATOM 2715 N GLU c 235 99. ,811 55. .157 106. ,346 1. ,00 42. ,64

ATOM 2716 CA GLU c 235 99. ,763 56. ,606 106. ,133 1. ,00 42. ,97

ATOM 2717 CB GLU c 235 100. ,978 57. .068 105. ,324 1, ,00 43. ,47

ATOM 2718 C GLU c 235 98. ,504 57. .169 105. .475 1. ,00 43. ,42

ATOM 2719 O GLU c 235 98. .195 58. .340 105, .654 1, ,00 43. ,34

ATOM 2720 N TYR c 236 97. .765 56. .358 104, ,726 1, .00 43. .63

ATOM 2721 CA TYR c 236 96. .581 56. .882 104. ,050 1. .00 43. .35

ATOM 2722 CB TYR c 236 96. .621 56. .480 102, ,576 1, .00 46. .25

ATOM 2723 CG TYR c 236 97, .982 56. .709 101, .961 1. .00 49. .41

ATOM 2724 CDl TYR c 236 98. .907 55. ,671 101. ,869 1. .00 52, ,22

ATOM 2725 CE1 TYR c 236 100, .179 55. .882 101, ,350 1. .00 54. .00

ATOM 2726 CD2 TYR c 236 98. .367 57. .975 101. .515 1, .00 51. .14

ATOM 2727 CE2 TYR c 236 99. .643 58, .202 100. .994 1, .00 52. .30

ATOM 2728 CZ TYR c 236 100. .543 57 .152 100. .917 1, .00 54. .30

ATOM 2729 OH TYR c 236 101. .814 57 .362 100, .425 1 .00 54, .97

ATOM 2730 C TYR c 236 95. .221 56 .534 104, .650 1 .00 40, .94

ATOM 2731 0 TYR c 236 94. .185 56 .933 104, .119 1 .00 38, .63

ATOM 2732 N GLY c 237 95. .223 55. .805 105. .759 1 .00 39, .11

ATOM 2733 CA GLY c 237 93. .969 55 .451 106. .390 1 .00 37, .11

ATOM 2734 C GLY c 237 94. .078 54 .300 107, .367 1 .00 36, .57

ATOM 2735 O GLY c 237 95, .119 53 .650 107, .478 1 .00 36 .30

ATOM 2736 N SER c 238 92, .991 54 .060 108, .093 1 .00 34 .87

ATOM 2737 CA SER c 238 92 .943 52 .974 109, .054 1 .00 33 .24

ATOM 2738 CB SER c 238 93 .251 53 .476 110 .455 1 .00 33 .21

ATOM 2739 OG SER c 238 92 .087 54 .057 111 .007 1 .00 35 .23

ATOM 2740 C SER c 238 91 .552 52 .375 109 .074 1 .00 31 .13

ATOM 2741 O SER c 238 90 .561 53 .055 108, .830 1 .00 28 .33

ATOM 2742 N ILE c 239 91 .490 51 .091 109 .376 1 .00 30 .79

ATOM 2743 CA ILE c 239 90 .224 50 .401 109 .467 1 .00 30 .00

ATOM 2744 CB ILE c 239 89 .998 49 .504 108 .250 1 .00 26 .28

ATOM 2745 CG2 ILE c 239 89 .705 50 .375 107 .026 1 .00 25 .43

ATOM 2746 CGI ILE c 239 91 .213 48 .613 108 .015 1 .00 18 .70

ATOM 2747 CDl ILE c 239 90 .999 47 .657 106 .886 1 .00 13 .24

ATOM 2748 C ILE c 239 90 .284 49 .581 110 .735 1 .00 31 .43

ATOM 2749 O ILE c 239 91 .370 49 .232 111 .196 1 .00 33 .06 o σι ( ι αι oo («l ^^ ^ ^ O 'a• m ιn ^D » ιil P^ r^■ σl ι ι^,) 'l^, (Il 'f "<^, in n en O H O ^ ιfl O W "> ^Il ln J ^o n ^^, r^ ^ ιι r^ H ω oo o ιn n o ^ o ι rl o ^ ^ ri (M o o r• ιfi ^o m ιn ^ lD ι o^ O H ιΛ N Ol ri O O Uι (Iι 3 ^!⁾ ι 1^| ιn IIJ r o CM CM OO OO OO OO CM CM CM CM CM CM CM CM O^ oooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooo σi N ^ N H m iD n cvi m in ω o m n ci ^ ω m iD in ω t fD ^ n ch ω ^ H H N ^ ^ N o ω o oi r- σi m iD N io o w iη ic co N H in H o * o o ^ ^ H ^ ^ ω Λ ⁽n N » n ι ^ o ^ ^ m o ^βι v ri ιo v (Λ ιn ιΛ (ι Λ ^β ffl ol ιn oo ιn N N ^ ι^ι oo ( ι W H^ ⁽n ^ ^l⁾ ^o o⁽ n o oo n ιn ^ ω H co ι ^ ιD ^ ^ ^ (I) <Λ o ι oo v ^ co ^ ιD H Λ <N ω o ^ n w ω to o w (η "f ⁽η ^ H | lc ιc ^D r- lIl w ^ c^ι ιD N H co ιn v ιn

H N (D iη fl ( N H (D (D N N ( ri i N ^ m ιn ^|-i r- ι^ σι ιo ifl r- oo ^ iD ι ^ ιn « OO CM Cn θ Cri rl rl CM CM rH r rl O CM r r "tf O "tf «tf m 'tf σl N H o3 σl o cn cn o cn cn cn cn cn o o o o o O rl o oo r~ oo r-~ r~ ιn 'tf in r- r- ιn

"tf o "tf o c co θ "tf ro oo co co oo oo m oo co oo co

m m t»

OO OO OO

υ o oa u υ υcj u u υ c u υ υ υ u υ u υ u u υ a oo o u υ cj u o υ υ υ υ ou υ u υ uυ u υ u o u o u u u υ u υ

Z Z Z Z Z Z Z Z co co co co co co co co co co OS PS OS PS OS PS PS OS OS OS PS OS OS DS PS PS OS PS OS Z Z Z Z Z Z Z SS Z D D D D LD D D D rl rl rl l rl rl rl H l ω tf tf tf tf tf tf tf tf a a a a a x x x x x x x x π i-a Ha H Ha Ha i- hi hi ω ω ω iii H B ω

EH -H EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH CJ CJ CJ CJ CJ CJ CJ CJ CJ rl CM CM rl rl CM tf CQ CJ Q Q tf CQ CJ Q Q Cxl Cx] tf CO CJ J tf CQ CJ Q ed Q di co a tf CQ CJ Q Cxl bl tf PQ CJ Q Q z υ cj o o z υ o z u cj ocj z υ z cj o z o c o υ υ o υ u cj cj u u υ υ o u o z o υcj cj o z υ o z o cj o u o o o z

oo oo oo oo co co cn in uo ri oo oo

o o o o o o o o o o o o m O CTl rl 00 rl Cn rl C0 ri m t-- r-- O r- oDoo M O o cM co c m c oo cn co H oo c oo r-- 'j^ι io ι r-- o M co r~ o oo r co r-- ιn oo ιn Λ ω ιD ω ιn ^ ^ α) co ^ ω m ω ιn

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rH rH r- c r~ r- rl i-H CO r- OD OO m v r~ cM "tf θ in in in ω in ^ n π N N H iη N N O O Λ co o m m ro ^ m m o o m ^ ^ in ^ n ^ in ^ n π oi fO 'J N H i n o o σi ffl co r- oo r- vo r-

O0 C rθ r O0 rO O0 O0 00 O0 00 O0 <^ 00 O0 CO CM CM C CM CM CM CM CM CM eθ rθ CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ rl O CM "tf "tf m rl rH ιn 00 00 in 00 CM 0000 O CM CM 00 O "tf iO ri en oo ro r~ o in cM in cM cn r~ vo cM ri o ^r co <)o oo cM O oo 'tf oo 'tf cn cM in cn < i io

■tf io c r^ oM f 'q' C 'tf ^' Co o o cn r- c m in o cM i^ o c σ^ o r-- "tf co L ^ co ιo i£> co r~ o r"-- ι ri r"- σ'ι o 'tf ri ιn <^ o cn "tf in ri c CM co oo m m o cM ri r~ ri m oo m ri co r-- r-~ m co r-- 'tf ri o ra oi "tf oo ιH θ r~ ^ cn σ^ ιH fθ ιH cn uo c ^ o ι r-- r-- oo o oo ri rH i r-- oo o r~ Ln r^

H o ol m o ι l P^ ι^,l ^ <J ιn l H H O CIl J to H l H H (^ι ^ t^ ^ ln o m o (!l O O O\ ^ a) ^ o o tJl o o3 ιJι tΛ oo o H W O N Λ o oo oo oo i^ r^ co ∞ co oo co oo oo ro co co co oo r^ r^ r^ co co co co co co oo co oo oo r^ oo r^ oo oo r^

φ ιn ⁽O lO lθ [^s (^ ι f. ^ | _r. (i) (i) ι_: (i) (lj oθ (I) IΛ irι <Il (Jl (Jl <II II1 51 01 0 0 0 0 0 0 0 0 0 0 0 H H rl H H H (\| N N (\| ( (V| N f)

^ ■ϊ "r "j ^ ^ ^ ^ ^ ιι^, ^^ι iϊ^t ^« Hτ ^ Hf ^ ^r ^ ιτ ^ ^' ^ ^ r ιτ ^ ^ "]i "]^ι t ιn ι ιn ιn ι ι ιn ιn ι ι ι ιn ιn tn ι ιn ι ιn ιn ιn ι ιn ιn ι o o u υ cj u o o o o u υ o υ o υ υ υ o υ o υ υ o o υ cj υ υ υ υ υ υ u υ υ o u o u o υ υ u u o u u u υ o c^j u υ υ ai aj tii Bi iiH af - i Hi ia Hi Hi j a Hi rl .-a ra πa ι-a D D D D D D D D D CJ CJ CJ O CJ CJ O CJ CJ CJ CJ PS PS PS PS OS OS O O O O O O O CO co co co co co co co tf tf tf tf tf tf tf tf tf t¹ a πi Hi J ia i i Hi 1-a pS χ oS pS S oS pS. oS oS oS oS ω ω cχi χ] CXI CXI PS OS PS PS OS CS I-S H tf tftftftftftf>>>>>>>> tf tf tf tf f

> > > > > > CJ CJ CJ CJ CJ C CJ CJ tf tf tf tf tf tf tf co co co co co co ⁽-j αι CL, ^Qj C-ι C-ι CLι a rl CM rl CM rl rl CM rl CM tf CQ CJ Q Q tf CQ CJ CJ tf O CD CD tf CQ CJ Q Cxl W tf pQ tJ Q Cxl CO a a tf PQ CJ Q tf CO CJ

U CJ u o o U O Z υ υ CJ υ o o z u υ υ O u o CJ CJ CJ U O O CJ O Z O CJ CJ CJ Z CJ Z Z O O Z CJ CJ O cj O Z CJ O CJ CJ U O ιn w ^ α! m o H (ι (o ^ ln ^o o w o H (ι (η f ι ω ^ co (Λ O H ( n ^ ιn ω ^ co ffl O H N P^ 'τ ιf) ^D (D σl O H | { •* ln ω ^ o3 Cfι o o o o o H H H H H H H H H H N N N N N N N N N N in ( rι ιn n ι ro (») (^,i "!' ^ ^ "]' 'r ^ "i "ir '3^, 'i ιn ιn uι ιn ιn ι ι ι ιn ιn

OO OO ∞ OO OO OO OO CD OO OO OD OO OO OO OO CO OO OO OO OO OO OO CO OO OO OO OO OO OO CO CO CO OO OO OO OO OO OO OO OO OO OO OO OD

00 CM CM CM CM CM CM CM CM CM CM CM I CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ rH se

© 2222222222222222222222222222222222222222222222222222222 O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O o tf E^HtfEH EtfHtfHtfEH EtfH Htf tfEH Htf tfH Etf^HtfEHtfEH Et_fH Et_fHtfH EtfH EtfH EtfHtfEHtfH EtfH EtfH EtfH EtfH Htf tfHtfHtfH Htf tfHtfH Etf^H Htf tfH tf^H EtfH EtfH EtfH EtfH EtfH EtfH Htf EH H EH H H EH H H EH H H H

oo r- rH θ co cM in cn co oo >-3 ri co oo <τι CM in co co o ri P- co cM oo oo m "tf ro co r- o io oo io o r- "tf rH o o ro r~- o cM co io oo "tf "tf in r~ oo

Λ v Ol N H O CKO n m O n iB rl fl V lfl flO Ol in rl rl CM CO CM rl 'tf CO eO OO CO O OO r- co cn io cn r- cM m co cn cn p- cM ^o oo cM cn ri oo oo r- oo r- oo r ^D cn r~ ^o r- in oo oo cn o ri cM ri r- in cn o en o cM co ιn oo co c cM θ in ι< <Tι u 'tf CM c 'tf ^f o m o '" ιn σι m co c 'tf t— CO CM r— oo oo oo o o SO ^ ιn ιn >J^, 1 l (n f^,) t^ (η «) ^ ^o ιD oo ^ o^ ^ o^ m O H O o o H (Λ o σl (D tD H H M (^,^ "l' CM H lM H H ^ (η ri N rl rl rl rl CM CM H H H H H H rl H H H H rl H H H H H rl rl H H N M N N M N H C H H H H M N N CM N t C N l M I I M M _rH "tf 'tf θo cn θ 'tf r~ oo m co cM θ ri ι-H Lθ 'j^, C e oo r~ oo co oo co m co σι ι^ r~ m w «) «i ιn "i' i ιn ιn i£) ^ ω 'ϊ in tD N N H H r rD i^,) (^,f) » ιn >D ιn cj H N θ θ (Ji oo oo CM o O rl O CM CM OO rl rl O r^ r^ r~ r~ r~ r^ c^ r~ r~ r~ r~ r^ r^ r^ r~ c^ [~ r~ r~ i^ r~ r~ r~ r^ r^ r^ r-- r^ r- r~ ρ~ r- r- r- r~ ιo co ιjo r- r- r- r- r~- r~- c-~ c- r- r- r-~ r-

o o co c co r o cθ _"tf ^ "tf «tf 'tf _"tf 'tf "tf ^ ^ 'tf i ιn ιn ιn ιn ιn ιn co <o o ι ιo ιj3 o co r^ in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in ^

CM CM CM CM CM CM CM CM I CM CM CM CM CM CM CM CM CM CM CM Cvl CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ o c υo oυ ooo c u oc cj uυ u uoo u uocj uooocj uυ uυu ocj ooo uo cjυuoo ucj u u υ o uo cj

CO CO CO CO a a c j tf

CM rl rl CM rl CM tf CQ CJ Q Q Cx] Cxl tf cQ c Q txi to a a Q tf PQ CJ CQ CD CD Q tf PQ CD Q Q t Q υ o c cj z cj z u o c υ o u z υ z z c o Z CJ C_> J CJ tf o Z CJ J J J υ O z O υ O CJ O CJ o z tf CQ f CJ o CJ O Z CJ O O O Z

O H M n >» lo ω io w H ∞ oo oo oo

CM CM CM CM

00 rH se 2 22 2 2 22 22222 22 lH O O O O O O O H o o o o o O O

H H E rH O tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

O

CM w o o e- oo

00 n in

H

N ιH n cM CM ri ri c 'r ιn 'tf θ θ o oo o oo oo o o ri ri cM θ θ cn cn oo r~ o ri cn o ω W H ^ m "^ O N Oo m r o a c^ι W Λ Iη o ιO '» o ιn σι t ^ ^ ^cι tD ^ o ^^l H ■ϊ ιn o ^ι ^ ^ι rl ^ lβ (^ι w ιS (^,l ^ ^ H H (») ιn ^D N ιn ^ (J a ^ H ιn O '! ιn co o ιI) (o ιn ιo ιJl (D Ol ^^ ^B ^o ι^η o ^o (^ ^ ι^⁾ (!l "l' 'a' ι (^l (Jl H ιn o o ω o ιn ^l H H O ^ oo (Λ ^ (s (D ^ ■» ^J ln H co ι ^ H O l ^ ⁽η σι ⁽^l H ^ Φ ιn o f ιn N H Φ w M ^ ^■J W o tη M ^ H ⁽I\ ⁽η H ^ o t^l ( m tD ω H ^(<l ⁽5ι ^ n ιn <n ιn ιn 'ϊ ( ra r~ oD Cθ i£> co ιo co co r^ ιn 'tf "tf co r -tf in ^ ^ ^ oo ( ro <M r 'r o t ιH CM o σι oo cn OT cn cn oo oo oo r^ r~ ∞ i" ^{φ φ} Φ io ιo ιa iD i^β iD io » w ω w ιι iD io iD iβ io ιC) io iB iD io ιa « ιo ιo ιo ιn ιn ιn ιn ιn ιn ιn ιn ιn «

o o H H H H H H H H csι w N N t^l N ^\ (η (^η (η n π 'l' 'ι^, ^ 'l^| v ^ ^ ^ ι ιn ιn ιn l ιn ι) ι ι^ ^o ^fl ^o ω ^D lfl ^D ^ ^ ^ ^ ^ ^ oD oo κ& ^SO *& ^SO ^SO SO SΩ <& SΩ SO SD SO SO <& SO ^ SΩ SΩ SΩ SO SΩ SΩ S SΩ SO SD SO SΩ SO SΩ SΩ SO SΩ SΩ SΩ SΩ SO SO SΩ SΩ SΩ SΩ SΩ SΩ SO SΩ SΩ SΩ SO SΩ SΩ SO SD SΩ ^ CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM C^

O U O O CJ O CJ CJ CJ O CJ CJ O CJ CJ CJ CJ o CJ o O o CJ υ o CJ o o o CJ CJ CJ U CJ CJ CJ CJ U CJ O J u u u o cj o cj cj o υ o cj o o X X D O O D D D D D O O O O O O O t tf z z z z z z z z CO CO CO C CO CO CO CO C PS P OSS I-S o oS PS rt j a _Hi _Hi j j j ^ _fi;

H i- ω ω ω ω ω ω ω ω o o oS oS ^QS ^QS ^QS J tti di Λ αj Oj αi Oi If

3 3 Hi co co co co x x x x x x x x x a u O _hj j j ia i j J i a a a a a a tf tf tf tf tf tf tf ι-ι ,-a tf tf f tf tf tf tf tf tf tf Hi α ^u a ta ia ia Hi EH EH > > > > > > > tf tf rl CM 3 t rl rl CM rl CM tf CQ CJ Q Q Q tf CQ CJ tf CQ tf CQ CJ Q D tf CO J J tf CQ CJ CJ tf

O O z CJ CJ CJ υ CJ υ o z uuυuu z u CJ CJ O z CJ CJ o O z υ o υ υ cj u cj z υ o z J υ o CJ CJ o z cj cj cj o c o z cj ιn w ^ ffl c^ o d c^ι n ^ ιr) Φ ^ ω o H ^ι ^D |^| ι w ^^• ra m o H N ιn ^ n ω ^ oo σι O H N ^ « ι ω ^ ffl c^ O H N f^ ^ ιn a ^ co cn ιH ri ιH ιH ιH CM CM CM CM CM CM CM CM CM CM co co oo oo oo c oo oo ro oθ 'T "tf "tf ^ "tf -tf ^ 'r ^ "tf in ιn ιn ιn ιn ιn ιn ιn

00 c cnn c ono c ono ccnn ccnn cn cn cn cn en cn cn cn cn cn cn cn cn cn cn cn cn cn cn σi cn cn ixi cn cn cn cn cn cn cn cn cn cn c^ rH CM CN CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM C se

© 222222222222222222222222222222222o22o2oo2o2 O ooooooooooooooooooooooooooooooooo o2o22oo22oo22o2oo22oo2o2o2o2o22o2o tf tf tf tf tf tf tf tf tf tf tf tf tf tf t_f t_f t_f t_f t_f t_f tf t_f tf t_f t_f t_f t_f t_f t_f t_f t_f t_f t_f t_f t_f t_f t_f t_f t_f tf t_f t_f t_f

Table 1

ATOM 2970 CB ALA C 268 49, .595 22. .410 164. 763 1. ,00 47. 07

ATOM 2971 C ALA C 268 49. ,296 20. .635 163. ,054 1. ,00 47. .68

ATOM 2972 O ALA c 268 49. .272 21. .056 161. ,898 1. .00 47. ,58

ATOM 2973 N LEU c 269 48, .520 19. .647 163. ,481 1. .00 48. ,97

ATOM 2974 CA LEU c 269 47. .563 19. .008 162. ,593 1. .00 49. ,91

ATOM 2975 CB LEU c 269 46. .675 18. .044 163. ,390 1. .00 51. ,98

ATOM 2976 CG LEU c 269 45. .568 17. ,292 162. ,645 1. .00 54. ,75

ATOM 2977 CDl LEU c 269 45. .328 15. .925 163. ,300 1. .00 55. ,71

ATOM 2978 CD2 LEU c 269 44. .290 18. .139 162, ,639 1, .00 55. .58

ATOM 2979 C LEU c 269 46. ,721 20. .087 161. ,923 1. ,00 48. .50

ATOM 2980 O LEU c 269 46. ,225 20. .987 162. .584 1. .00 48. .65

ATOM 2981 N GLY c 270 46. .592 20. .016 160. .607 1. .00 48. .14

ATOM 2982 CA GLY c 270 45. .795 20. .999 159. .901 1. .00 48. .37

ATOM 2983 C GLY c 270 46. .556 22. ,163 159. .297 1, .00 47. .96

ATOM 2984 O GLY c 270 45, ,988 22. .941 158. ,525 1. ,00 48, .79

ATOM 2985 N SER c 271 47. .834 22. .285 159, .632 1, .00 47. .43

ATOM 2986 CA SER c 271 48. .664 23. .371 159. .109 1. .00 47. .85

ATOM 2987 CB SER c 271 50. ,043 23. .337 159. ,769 1, .00 45, .66

ATOM 2988 OG SER c 271 49, .938 23. .210 161. .171 1. .00 44, .73

ATOM 2989 C SER c 271 48, .858 23. .296 157. .593 1. .00 48, ,34

ATOM 2990 O SER c 271 48, .412 22. .363 156. .936 1. .00 48. .78

ATOM 2991 N ASN c 272 49. .541 24. .291 157. .050 1. .00 48, .71

ATOM 2992 CA ASN c 272 49, ,832 24. .335 155. ,628 1. .00 50. ,82

ATOM 2993 CB ASN c 272 49. ,206 25. ,563 154. .969 1. ,00 53, .33

ATOM 2994 CG ASN c 272 47. .752 25. .369 154. .639 1, .00 55, .48

ATOM 2995 OD1 ASN c 272 47. ,377 24. ,398 153, .983 1. .00 57, .95

ATOM 2996 ND2 ASN c 272 46. .919 26. .303 155, .078 1. .00 57. .55

ATOM 2997 C ASN c 272 51, .337 24. .437 155, .474 1. .00 50. .91

ATOM 2998 O ASN c 272 51, ,885 25. .539 155, .492 1, .00 52. .42

ATOM 2999 N VAL c 273 52. ,011 23, .304 155. .320 1, .00 48, .89

ATOM 3000 CA VAL c 273 53. ,459 23, .323 155. .167 1. .00 46. .82

ATOM 3001 CB VAL c 273 54. .099 22. .146 155, .931 1. .00 47. .39

ATOM 3002 CGI VAL c 273 53. .438 20, .863 155, .529 1, .00 48, .39

ATOM 3003 CG2 VAL c 273 55. ,587 22, .079 155. .654 1, .00 48. .76

ATOM 3004 C VAL c 273 53. .874 23, .265 153, .702 1, .00 44. .84

ATOM 3005 O VAL c 273 53. .117 22, .783 152, .858 1 .00 45, .60

ATOM 3006 N GLU c 274 55, ,060 23, .794 153. .402 1, .00 42. .50

ATOM 3007 CA GLU c 274 55. .591 23, .756 152. .042 1, .00 41, .08

ATOM 3008 CB GLU c 274 55. .197 25. .008 151, .260 1, .00 42, .81

ATOM 3009 CG GLU c 274 55. .946 26. .261 151, .641 1, .00 48, .27

ATOM 3010 CD GLU c 274 55, .372 27, .499 150, .969 1, .00 50, .91

ATOM 3011 OE1 GLU c 274 54, .191 27, .820 151. .232 1, .00 52. .00

ATOM 3012 OE2 GLU c 274 56. .093 28, .149 150. ,179 1. .00 52, .04

ATOM 3013 C GLU c 274 57. .112 23, .606 152. .093 1, .00 38, .22

ATOM 3014 O GLU c 274 57, ,798 24. .370 152. .764 1, .00 35, .80

ATOM 3015 N PHE c 275 57. .623 22, .597 151. ,391 1, .00 35, .82

ATOM 3016 CA PHE c 275 59, ,056 22. .303 151. .356 1, .00 32. .70

ATOM 3017 CB PHE c 275 59, .286 20, .793 151, .208 1, .00 27. .90

ATOM 3018 CG PHE c 275 59. .061 20, .007 152, ,468 1, .00 21, .37

ATOM 3019 CDl PHE c 275 60. ,002 20, .013 153, .479 1, .00 19. .05

ATOM 3020 CD2 PHE c 275 57, ,906 19, .257 152, .638 1, .00 18. .11

ATOM 3021 CE1 PHE c 275 59, .792 19, .283 154, .643 1, .00 18. .55

ATOM 3022 CE2 PHE c 275 57. ,693 18. .532 153, ,790 1, .00 14. .62

ATOM 3023 CZ PHE c 275 58. ,631 18. .540 154. ,794 1, .00 15. .13

ATOM 3024 C PHE c 275 59. 759 22. ,996 150. .209 1. .00 32. ,68 θ '<tf σi ri O O oo

AH ooooooooooooooooooooooooooooooooooooooooooooooooooooooo rl rl rl rl rl oo o in r- ri fη rl "tf 00 00 rl n M 00 CN r- o "J c o o cn o o τ ιn "tf i* ιn ιn rl rl rH rl rl rH

« ^ ιn ιl ιn o ιn » N O <ι^ι ^ o oo ιn n m ^ « flo N N ^ 'ι^, ιn ^(,1 ιι⁾ 0 (0 '* ^ co ^ Φ o m ιn o m ol ⁽^ι r^• ^^ o ιn H O o ιη o ol O f^|l o ^ ln ^ m o3 ιn o ∞ ι ( lo ^ Φ ^ l ω (^^ ^ to ^ ιn •* κι m H lil ^ι f ^ⁿ H o ol ^ o ^ ιn o H (^l N (^) ιn oD ^£ι m o ^ ln H ^ι u) co o tD co M H ^ O H ^ i ω o H n t in o co ω in ^ ϊi H in h ai ω o i'i r- iJi in H iϋ H oj rt iη ^ in ^ ai m ω ai ic in fn iΛ ifl N ^ ^ iη H o o o ro ιn >o r^ oo cM CM c c oo θ rH cn θ "tf i (^ e o c^ rH θ rH r -tf CM eo ^,tf "tf i 5 θ "tf i ι c rH cχi i o c c^

CM CM CN CM CM CM CM CM CM CM CM CM CM CM rl l J CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN C^ rl ιn rl rl r- ^r OO CM rH rl "tf ^' CO Cn 'tf rH r-- r~ "tf ⁽M rl Cn θ O rH r-- l rl rl r-~ l ^t^l i i rl C0 rl 0 O ^l' P~ 'tf <x> '* oo a> en in io cn ri iO in oo

■ ■tftf iioo --tftf CCMM ccoo ccMM oθ σσiι --tftf CcDo oO ccn rrii oo ccMM CCM CCMM rr^^ oo oo oooo rroo oooo r-- o r^ ri oo ιn ^o cN oo cn ri oo ιn 3 rH cM io cn oo r- o -o- L ^■n- r -~ o —o o — rl ^■ U mO ' Ttf oo CN in ιH θ cθ "tf 'tf 'tf θo cθ '^ '^ ι cM c^ i 'tf in c co cM C c co oo oo θ r~- ι oo oo θ i c r^ cM θ oo >o oD r- cN Cθ Lθ cn oo cM θ oo oo CO rl o "tf "tf ^F cn rH rH CM ri cM CM CM co oθ "tf in i' '3^, ιn u3 r-~ r~ oo co r~ oo r^ co r- cn cn o ri 00 «tf 0 "tf Lθ lO m cθ CN CN CM CM rH ri cM N t^l 'j' m co r~ ιn o c "tf ι lO ^lD lD lD l0 lD D lD \O D lD lD lO ^D ^ lfl lO lD lD ^ lD lD ^D Φ ^ U [^ r- r- r- r-- r~ r~ r-~ r- r- r-- r- r-~ r~ r-^ r- r^- r- r- r^ r^ r- r- r^- r— r- r~

ln ^ ^o ^ ^lfl ^^β ^ ^ ^ ^ ^ ^ co o^ o oo c ι3l (Jι ιJl ffι ⁽]l σl (Jl o o o o o o o o o o o O H H H H H H ^ι ^ι ^ι l ι ^l (ι c^ι ι^,) ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ o co oo ω oD 03 o co ω ⁽ ι co co co oo o ⁽» () o^ o^ co o3 CO » ω tD co oo rø

CN CN CN CM CM CM CN CN CN CN CN CN CN CM CN CM CN CM CM CM CN CM CN CM CM CN CN CN CN CN CM CN CN CM CM CN CN CN CN CM CM o cj υ o υ o υ o o o o o o o cj υ o υ cj o o cj o υ c o o o c υ cj c υ o o cj u c o o cj u o cj υ u cj o o υ u o cj o c

W EH EH H H EH H h ^ w w w w w c tn t w w w iJ j Hi a ia a H oS o oS ^p oS oS ri P o oS o ι^ o o ^p cc; ^pi oS θj C-ι aι -ι -ι aι CLι Cι θ θ a ω txi txi cxi cxi ω cxi ω x x x x x x x x x x x tf tf tf tf tf tf tf x x x x x x x x x x x x co co co co co co co co cxi ps

OH 2 2 2 2 222 o υ υ υ u t H ι-a H Ha H > > > > > > EH EH EH EH H EH EH EH EH H EH EH H ω cxi w ω ω co co co co co co tf tf tf tf tf tf tf tf cn c-i rl CM rl rl CM CN rl CM tf CQ CJ Q W tf CQ CJ tf CQ tf CQ CJ CJ f CQ CJ Ω W ^Q tf PQ J Q α Q o z υ o cj co υ o o z o cj ^[χ] co a tf CQ CJ

O CJ CO Z J J J z o u cj υ cj o t υ cj cj cj c cj cj u o o o Z O CJ O J O Z CJ O O O O CJ O Z CJ ιn Φ ^ ω m o H N n ^ ιn ω ^ ω (I>O H N n ^ ι ω ^ ffl !!l O H (^J t ^ ιn a ^ o^ (3l o H N ι¹^ "l^| ιn ⁿ α3 (JlO HNfn 'ϊ ιn ^β ^ co <Λ CN CN CN CM CN Oo oo oooo oo oD ooco oo oO 'T 'r _'tf _'tf 'tf _' 'tf 'tf ' -tf in in in in in in in in in in i^

00 rH o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o se oo co oo oo oo oo oo oo oo co n oo n oo co oo oo r e oo oo c n oo oo oo oo oo oo oo oo oo oo oo oo m oo oo n

© 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O EH H H EH H H H EH EH H EH EH EH EH H EH H EH H H EH H H H EH EH EH H EH EH EH EH EH H EH E-< H fH EH EH EH EH EH EH H EH EH EH H EH EH H H EH tH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

I O " 00 00 CN 00 CN Cθ L0 CN 00 00 C0 r- T oo co oo co oo •^ o in r~ oo ri r- 00 CO 00 rl ri oo m cM CM r- oo -c 'tf oo oo r- oo in oo cn co o r- m fi co oo i-θ ι-o o ^t' "tf r- o *o - i o in in r- oo co «a< r- o in ^■w in in oo r- LO ^> oo "tf o N co ^ co o (^ lIl o o ^ ^β H (n to ul ^ ιn ιn ln

JS

© I <^ σι o (_Jι o o _{Λ Λ} o o (D _H ω a ^ ^ co o^ t_D ffl ι o o to ^ ^ » oo co ^ » c^l (D ^ O 'J ιn ^ (D ιη ^ p^ H ^^ c>J H)ι (η ιn ιn ln ^ H^ ^ © CN CM rO CM CO C^ CN CM CO CO rO C CM CM CN CM CM CM CM CM CM OO OO CO CO CO CO rO CO CM CM CM CM CM rl iH CM CM CM CM CM

CΛ ooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H ooooooooooooooooooooooooooooooooooooooooooooooooooooooo υ rl rl rl rl rl rl rl rl rl rl rl rl rl rl

AH

ri o cM r- en oo r- o o cM r- o s in co m "tf ιH r-- o r^ oo ιH co <τι o o o ι ιn ^, CM i ιn oo o ι oo o θ i ιo co 'tf o σι r~ co ιn vo n ι-H o

CN CN CO CO rl rO T 00 CN "tf r- CM 00 rl 00 rl in ri o -tf "tf ^ oo oo r~ co o cn co cM in oo r^ o oθ ιH CD θ rH C co oo r- "tf ^D CM θ CM H o r- o co c oo m ri r- "tf oo co co co oo ri ri ri 'tf ro r- ri r- 't_f oo θ ιr θ in cM r^ "tf in c ιn 'tf in cN CM r-- co 'tf oo ιn ^,^ σ^ ιH r^ oo ιn N r~ ri ri ri θ ri ιn o ιo o cn cD O O o o o ri oo ^r oo oo oo oo oo oo o oo cn r~ co m "tf i r co ^i" CO LO r- r- co oo oo o co co in in oo cN ri ri o m ιn m m u3 r~ oo oo r~

CM rl rl CM CM CM CM CM CM CM CN CM rl rl rH CM CM rl rl rl rH rH rl rl rH CM rl rl rl rl rl rl ιη O v l ( n H H m co ^ ^ ^ ^ ω ω oo o3 co ^ ω ^ w ι u^{) ■}» ^ m ^ι l H O ^ ιn ^ ^o p^ ^ι ^ "l' H H ri o o m ιJι w o o H σι <Λ co cD lJl O c r~ r~ r~ r^ r^ co ιo ιo i" o co i£) i co ιo ιo vo co vo co ιjo o u5 io ^ co co j c ιo co cD i co ιo i" io c^

(η ιη π (D ^ ^ ^ ^ ^ v ιa' fl ^ ιn ιn ι ιn ιn ιn ιn a ιc ^D ^ ιc ιo ιD ω φ Φ ^ ^ ^ ^ r- ^ cD co co co ro ω co ω oD m (5\ σ m J^ m o m ω co ω ∞ ∞ ω αi m m ω m m m oo oo o oo oo oo m o cD tD m cD m m ω o ω ω m ω ω oo Φ ω m m oo α m ω m m ω oo co o ω cD ω ω oo

CM CM CM CM CN CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM ^{■ _ "} J CJ O O CJ O O U CJ O CJ CJ O CJ CJ U U CJ CJ CJ J O CJ U CJ CJ CJ CJ O O CJ U U z z z z z O O O O O O O co co co co co co co co ccoo ccoo ccxxii Ccxxii ccxxii txi ω ω cxi cxi z z z z OJ C P-I Q-I O-I C CLI a ,a a j a t- α; β; κ; t, β; cS H H H H HH HH MH Hrl HH ^{• ■} HH ^{■ ■} jM - aH -l jH ~ HHa HHl H.-al Hι-l Hι-a Ha z z z M H.- H z lH-l Hl H HIl HHIl HHIl HhIl OS OS PS os OS PS OS cj cj cj cj cj c c c-i C-i c-i c-i C-i C-i a a a a a a a a a a rH HH rl rl H rl rl rl CJ CJ CJ CJ CJ CJ CJ CJ CJ EH EH EH EH EH H EH

CM rl rl CM CN rl rl CM oo tf CQ CJ tf PQ CJ Q Cxl W α tf Q D tf CO CJ Q Q Cxl Cxl tf CQ CJ CJ Q tf CQ CJ Q Cx] Cx] ocjooozoυocjozυ tf CO CJ Q Cx] Cxl

0 2 U U U U U o zooυcjzoz U 0 2 U U U U U 0 0 Z O J O U O Z O O Z O U O O O CJ

O ri cg n co c o rH CM O 'tf

CO CO ⁽D CO ICMN ICMN ICO'l C IO'J IO'OMO'O) IO'O) O O O O ii--HH rrll rrHH rrHH rrHH rrHH rrHH co oo oo co oo rH se 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 22 2 2 2 2 22 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 22 2 2 2 2 22 2 O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O

© tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf O

Table 1

ATOM 3135 CDl TRP C 289 59. ,015 18. 421 144. 331 1. ,00 25. 66

ATOM 3136 NE1 TRP C 289 59. ,731 19. 520 144. 743 1. ,00 25. 92

ATOM 3137 CZ2 TRP C 289 60. .881 20. 161 146. ,883 1. ,00 22. .40

ATOM 3138 CZ3 TRP C 289 60. .665 18. 451 148. 600 1. ,00 21. ,27

ATOM 3139 CH2 TRP C 289 61. .137 19. 706 148. ,152 1. ,00 24. 99

ATOM 3140 C TRP C 289 58. .502 13. 709 145. 125 1. ,00 25. ,97

ATOM 3141 O TRP C 289 57. .590 13. 261 144. .437 1. ,00 27. ,01

ATOM 3142 N LEU C 290 58. .983 13. 089 146. ,198 1. ,00 26. 09

ATOM 3143 CA LEU C 290 58. .471 11. 801 146. ,643 1. ,00 27. .29

ATOM 3144 CB LEU C 290 59. .505 10. 698 146. ,424 1. ,00 29. .58

ATOM 3145 CG LEU C 290 59. .621 10. 020 145. 068 1. ,00 31. .88

ATOM 3146 CDl LEU C 290 59. ,875 11. 031 143. ,947 1. ,00 33. ,27

ATOM 3147 CD2 LEU c 290 60. .752 9. ,027 145. ,170 1. .00 33. .26

ATOM 3148 C LEU c 290 58. .156 11. ,790 148. ,111 1. .00 27. .39

ATOM 3149 O LEU c 290 58. .697 12, .586 148. .875 1, .00 25. .52

ATOM 3150 N LYS c 291 57. ,264 10. ,885 148. .498 1. .00 28. .19

ATOM 3151 CA LYS c 291 56. .981 10. ,704 149. .907 1. .00 29. .65

ATOM 3152 CB LYS c 291 55. .547 10. .994 150. .298 1, .00 29. ,20

ATOM 3153 CG LYS c 291 55. .458 10. .873 151, ,802 1, .00 28. .12

ATOM 3154 CD LYS c 291 54. .082 10. .971 152. ,347 1. .00 31. .10

ATOM 3155 CE LYS c 291 54. .147 10. ,840 153. ,863 1. .00 34. ,01

ATOM 3156 NZ LYS c 291 52. .799 10. .966 154. ,488 1, .00 38. .80

ATOM 3157 C LYS c 291 57. .260 9. .245 150. ,201 1, ,00 30. .38

ATOM 3158 O LYS c 291 56. .877 8. .369 149. ,429 1. .00 30. .70

ATOM 3159 N HIS c 292 57. .934 8. .984 151. ,311 1. .00 31, .77

ATOM 3160 CA HIS c 292 58. .255 7. .617 151. ,683 1. .00 35. ,38

ATOM 3161 CB HIS c 292 59. .533 7. .606 152. .500 1, .00 33. .90

ATOM 3162 CG HIS c 292 60, .738 7. .971 151. .698 1, .00 33. .72

ATOM 3163 CD2 HIS c 292 61. .298 9. .173 151. .428 1, .00 33. .65

ATOM 3164 ND1 HIS c 292 61, .463 7. .042 150. .986 1. .00 32. .94

ATOM 3165 CE1 HIS c 292 62, .418 7. .656 150. .311 1, .00 32. .86

ATOM 3166 NE2 HIS c 292 62, .340 8. .950 150. .562 1. .00 33. .51

ATOM 3167 C HIS c 292 57, .110 6. .976 152. .436 1, .00 38. .27

ATOM 3168 O HIS c 292 56, .590 7. .535 153, .402 1. .00 39. .32

ATOM 3169 N ILE c 293 56, .740 5. .784 151, .992 1. .00 40. .65

ATOM 3170 CA ILE c 293 55, .616 5. .069 152. .565 1. .00 43. .55

ATOM 3171 CB ILE c 293 54, .598 4. .875 151. .447 1. .00 43. .18

ATOM 3172 CG2 ILE c 293 53. .368 4. .172 151. .951 1. .00 44. .52

ATOM 3173 CGI ILE c 293 54. .277 6. .252 150. .870 1, .00 43. .20

ATOM 3174 CDl ILE c 293 53. .296 6. .236 149. ,748 1, .00 48. .45

ATOM 3175 C ILE c 293 55. .914 3. .737 153. .279 1. .00 45, .41

ATOM 3176 O ILE c 293 56, .903 3. .058 152, .976 1 .00 45, .28

ATOM 3177 N GLU c 294 55. .068 3, .391 154, .252 1 .00 47, .39

ATOM 3178 CA GLU c 294 55. .204 2, .140 155, .008 1 .00 50, .70

ATOM 3179 CB GLU c 294 55, .286 2, .436 156, .512 1 .00 48, .39

ATOM 3180 C GLU c 294 53. .959 1, .310 154, .706 1 .00 53, .03

ATOM 3181 O GLU c 294 52. .850 1, .754 154, .971 1 .00 54, .66

ATOM 3182 N VAL c 295 54. .138 0, .104 154, .172 1 .00 56, .24

ATOM 3183 CA VAL c 295 53. .010 -0, .777 153, .810 1 .00 59, .45

ATOM 3184 CB VAL c 295 53, .401 -1, .659 152. .576 1 .00 58, .62

ATOM 3185 CGI VAL c 295 52. .315 -2, .666 152, .255 1 .00 58, .90

ATOM 3186 CG2 VAL c 295 53. .639 -0, .773 151, .363 1 .00 56, .91

ATOM 3187 C VAL c 295 52. .538 -1, .684 154, .972 1, .00 61, .72

ATOM 3188 O VAL c 295 51, .394 -2, .158 155, .024 1, .00 61. .54

ATOM 3189 N ASN c 296 53. .456 -1, ,910 155, .894 1, .00 63. .81 H ω (η o3 c o eo oo O O oo r- CO cN in co c in o o r- O C0 CM CM CCMN θ_ c c co rH Lθ cn LO

CO σi rl ιn r- "tf oo co i' ιr oo r-- Lθ

^ ω ι ιn ^o ^n "l^ι ^^ "tf O O r- 00 ι ιn ιn ιn "i^, ^ ^ <j ^P ^J ^* ^* ^^ rH ιH ιH ιH oo cN -tf co co o ι-H co co o θ ri ro r rH io cM in '>tf ^, ι oo co oo r-- ro cM in cM in »θ 'tf co m o cN "tf cn r- cM θ oo cM CN ^ o cn τ co oo ro o cN ri cM θo c oo oooo i r^— ccnn --tf=r iin i r c cD O 'tf oo cD m o co cM in oo co o cO rH CO 'tf iO 'j' oo 'tf cn ^■tf CN o m ro o3 "tf in ri oo oo o oo oo rH co >O ri cM cO rH Ln in co so ri oo ir in o en r- o 'tf ro cN co o oo co ro ri cO 'tf m cn cn co cri r^ cN co ι-H ιH cn r ιn co ^D r^ r^ cτ> ^r ri r~- 'tf θθ ιi' Cθ "tf in o r- 'tf r Lθ

CM oo m CM o O CN OO OO O O O rl CN CN OD OD uO O O o rl rl O O CN CM CN 00 T m in co r~ I— ifl i i 'j ci i'i N 'j' i' i' 00 i I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

n π ^ ιn tn "f 9 in Φ o ω ^ aι ^ oi ⁽⁾i o m tn oi (D θ o o H i ⁽η ιη ιn o o o c⁾i o N θ iιo o ι ra N i i N n oj N ri (\i '» ιn '» « ι ιn ιn Ln ιn ιn ιn ι ιn ιn ιn ιn ιn ιn Ln ι ιn ι ιn co ιn ι L ιn ^ co co cD co vo iD iθ co co ιo ι iΛ io co ιn c^

^ ιϋ ιc ιo ιo ^ ^ ^ ^ co <D a⁾ oo m ιJι Ol m m ιJl ffl m ffi <> ⁽S o o o o o o o o H ri ri H N M C ^ι l ( ^l (η (η m n ( (^ ιn (n ^ fl^, σι σι σι <Tv <τι θι cn cn cn cn cn cn cn cn cn σι σι σι σι crι cn cn cn cn cn cn o o o o o o o o o o o o o o o o o o o o o o o o o o o o o CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CN CM CN CM CM CN CN ΓO OO OO ΓO OO CO OO OO OO CO OO OO ΓO OO OO ΓO O^ υ υ c υ u c^j υ υ υ o u o u o o u o cj υ u υ u cj υ u u o υ υ o υ υ υυ υ o o υ o oo υ o o υ o o ocj υ o cj o o u z z z z z z z x x x x ps cci PS pS QS PS co co ω co co co co co co txi ω ω cxi ω ω ω X X X X O co co co co co co o o o o o o Cu P-i Oι eu z co Ha H i-a H -i Cxi xi ixi ω ω x x x x x x x H Ha H H Ha H πa z tf tf tf tf tf tf Hi 1 Hi π HI PS PS OS PS PS PS CO CO CO CO CO CO tf j cj cj cj co co co c c Ha ι-a _H Ha ι- H _{H H}i _H i H H ri ri ri M H J CJ J CJ Cu tti Oi Hi PL] tf tf tf tf tf tf tf tf tf tf rl CM CM rl rl rl CM tf CO CJ Q Q tf tf CQ CJ tf CQ CJ Q Cx] eg tf CQ CJ CJ Q tf Q tf CQ CJ tf PQ CJ Q Q

CJ CJ υ O Z J O z o υ o z cj J o c o z o o cj cj cj z u o z υ cj o υ υ c υ O z υ CJ tf o z u u u u u o z o υ υ o o CJ o z o

O H ⁽N ιη ^I» ιn ω ^ oo ol o H ⁽l n ^ ^ ω ^ ∞ Λ O H N ^^ "J ιn ^o ^ oo m o H l I'l ^ ιn ιo oo (Jl O H ( (^,l 'l^| ιn ιcι ^ oo o o r^ N ^^ ^ m Ol ^ l^ Φ tn Oi m m cn o O O O O O O O O O H H H H H H H H H H I N ⁱJ N N N N tSl M N M n tn oO ID I'l c t'i n i ^ 'I' ^ 'il' iJ ■H iH iH iH i-H rH iH iH rl iH CN CN CN CN CM CN CN CN CN CN CN CN CN CM CN eM CN CN CN CN CM CM CN CM CM CN CM CN CM CN oo oo cn oo m oo oo oo ro co ro co oo ro oD ro n oo oo m oo oo oo oo oo rn ro co n oo co n ro co

o

c rl CO rl OO CO Cn CD r- ^•^ oo co co r- CN O oo O O o oo cn cM cn o ιn ^ cD o cN cn co c ι-H ri o cM in o cM 'tf in co oo oo ιn ι-H n ι~- o cM cn r-- ιr cM OO LO O cn cO rl OO O O rH lO rH ' OO OO rl OO Cn oO H i _ri _CM m <» o ^ «) θ θ α) θ r- «) M «f ιn ci H fl θ θJ θθ H <rι ι3i v H «> ^ σι •q^, co o co oo O "tf c "tf in cri i- co cN oo o m "tf ri ι ^ oo ιn cN in ιn rH r~ r~ co c ri ij ιr ri r ι ιn ^ ιr ro r~ ιn σi rH in o o ιθ rH [^ co vo ιn r- in ro cn co cn co co r- r- cn rH Ln ri cN oo oo o r- rH oo cn o en oo oo t— r- ιn 'tf c 'τ oo oo co oo c cn α3 θo r~ on co o oθ rH ri cn σι θ ιH oo c r-- r_^ ι^o ι^ ι <Λ io ιθ 'jj r_^ o

T 'tf in "tf "tf T '3' "tf ιr '3" "tf 'tf "tf 'tf "tf "tf ^ ^ 'tf 'tf ιp "tf 'tf 'tf ^ ι ιn ^ ιι^, ιn ιn ιr i)^ι 'tf iι^ι "tf 'tf "tf 'tf "tf "tf "tf ^,^" 'tf

CM oo cN O CN r~ rH O c7i r-- oo in c3o o co cn rH co 'o cN cn cn oo oo co co co O _ "tf . _ .. r- co - cn m o o m co rθ ιH co r~ o oo cn r- ri ιo cn cn r- crv

00 CO 0000 CM CM 'tf o oo o oD oo co r~ O co r-- cn m co o ^r cM 'tf L ri in ^ o r- r^ m co ijⁱ m r^ ri o r- cD CM CN CM c c rO ri O CO O OO CD CM O o in oD "tf in m rH in oo oo iO ri oo oo ro o oo o "tf oo ιn "tf c cN "tf i rH in cώ 'tf ri oo f c ιt" cri ri r~ cn

'tf 00 itf o o o o o o o o cM CN oo oo T 'tf in co co in co in r- oo oo oo cn cn o cTi o cn o cn rH oo cD

^ ^ ^ ri cO (00 ) ^ "^ ω N ^ ^ m ^ ω ιn ω N (l H c ιn n H σι ω H H H ω ^ ω ιn "* ln •^ m σι r- co tD ιn ιn ^') ^ π H H _'t^ ^C H o ιo co ∞ cn c 'r io cN cθ 'tf r'-- ∞ 'r ιn ιH oθ !→ ιn co cn cn ι co o c o ιH θ C cθ "tf N i^

M ri iB n w oi ffl oo (D v o ιo ι» oo oo (» co fl H v v ^ o (Λ Λ ^ v ifl a o o w π n H n ι^β Hf θi H * ιn v θ H θ io o ifl (Λ n fl (iι n ιo r~ 3 oo 'r ιn oo c 'f Cθ ιn c ιH CM C ιH CM co o o n oo cD CD ιr~ r~ cD cθ r- r~ r~ oo r^ ιo ιo co co iD co co ιo vo ιχ> ιo co vD co cD i" CD 3 3 CD iD in ι-o ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ^

^ "a' "ϊ ^ "^ •ϊ ι ι ιn ιn ι ιn ιn ι ω ω ^J5 W ^o ιfl ^o ^ ^ ^ ι^ ^ ^ ^ ^ ^ ^ ^ ^ oo ω co ω co co co (Jl m m σι m Λ ffl m o o o o o o o oo oo co oo ro co oo co oo oo ro oo oD oo co m oD oo oo oo oo co m oD co oo oo eo oo co oo oD oo co m co r m oo oo

CJ o u o cj cj u c c cj υ c o ucj cju cj υ υ c c υ cj u o u o cj υ oυ c o cj o υ cj υo o υ o o o ocj cj uυ u o o υ z „ z_ z_ Z Z Z D D D D D D D D U O UO υO Oj O υO θO P-Sι PP-S. PPCS, PP6S CO6S PPSS PS OS PS o PS os πa Z Z Z Z Z Z Z Z Cxl Cxl Cxl bl Cxl Cx]

CO CO C C CO CO Cx] U Cxl [xl Cxl txl [xl Cxl OS l-S C-. CS pS pS pS X X X X X X X X X tf Hi Hi a πi Hi Hi Hi a a Hi hi a Hi Hi

CJ CJ O CJ CJ CJ CJ CJ rl rl rl rl rl rl rl CM rl CM rH rl CM CM rl CM rl CM CN rl rl

PQ CJ Q Q tf PQ CJ Q Q Q tf CQ CJ tf cQ cj α ω α cxi co a tf CQ CJ CJ tf CQ CJ Q W Cxl tf CQ CJ CJ Q CJ J O Z J O z CJ o CJ υ υ CJ o z υ υ o cj cj o z o cj υ υ ou υ cj o υ z CJ υ υ υ CJ o z υ o cj o o z cj o z o oυc o ιn ω ^ ω ⁽Λ O H N (π ^ ιn w ^ m Λ O H N n ^ ιn w ^ o^ m o H N lo f ιn ω ^ oo m o H N n « ln ω ^ tB ffl O H (^ι (η ^ ιn ιfi ^ o3 Il ^■" -f ⁱtf. 'tf "tf i ιn ιn ιn ιn ι ι Lθ in ιn co ιo iO co cD o iΛ co ιo co c~ r^ r~ r"- t^

CM CN CN CN CM CM CM CN CN CM CM CN CN CN CN CN CN CN CM CN CM CN CM CM CM CM CN CM CN CN CM CN CM CN CN C^ co oo n oo c m ro n oo c cn co c-o m ro n m c co co n oo co m co m n oD n ro m m co se

2 2 2 22 22 22 22 2222 22 22 22 22 22 O O O O O O O O O O O O O O O O O O O O O O O O O O H tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

oo ri "tf m co co cM m τ i' CM oo σι oo c 'tf ri vo r~ o H « oo H CO rl rl O 00 O

"tf 'tf "tf "tf CO "tf OOOO O O OOO O oooooooooo rl rl rl rl rl rl rl rl r- in r~ 'tf r- "tf H O W m o w H Iι

00 O LO 00 CM O ι N i N ω ι ι v o in ri i oo r- cn iJi iη o n in w tη o

00 00 "tf "tf LO CO 00 CO 00 00 CN •^ 'tf 'tf i ^ 'r C^ CO OO OO C CO OO CO CO rO OO CO CO C OO OO OO CN CM CM CO OO OO OO OO OO OO OO OO OO OO OO OO OO OO co o oo -tf in ir r— in r— oo i¹ rH O CO CN OO OO CO CN r- rl oo r~ oo θ "tf C rH o ιH "tf in cN θ ι-H in oo oo oo r-- ιn r~ ιn θ 'q' cn cN θ ri co o co co co <⁰ r- OO O rl if o oo oo oo r» co o cn co ri eo o co oo in r- >" r-- ιo ιo o cri Ln cN in co oo oo oθ "tf co o r~ CM r-- ιn cn r~ cn ιn ιr "tf oo oo oo o o co σι co in "tf so oo f m ri o oo in o rl CO CD OO rl O CD O Cn m < i iH c cD O iH CM co r~ in cD i «tf ^ o o r~ oo m <" r~ co co in cn r-- r-~ in ri in i o cn co

1-H C o u' θ 'r 'tf i ιn co r- oo o rH CM m m ιn Lθ "tf o oo co r- r- oo oo r-~ U3 co co oo o en o oo o OO O rl en en oo r- io oo O ri O ri o co rl rH rl rl rH rl rl rH rl rl rl rl rH rl CM CM rH rl rl rl CM rl CM rl CM rl CN CM rH rl rl rl rl rl CM CM CM CM CN rl c CM 'tf ^ C^ ^ tD n

-tf co -^ cθ 'r ''r "tf CN "tf ro ι ιn ιn ιn ιn ιn ι ω r^ in in in in in in in in in in in in in in in in in in in

o o H H H H H H H H W ι ^l N N ^l N (^l (^ι n n (η ^^ n n (D * "^ V "^^, ^ ιn ιn ιn ι » » a ^B W ^B ^ ^ ^ ^ ^ ^ tD <D ω o^ oo iH iH rH iH rl rH rH rH rH i→ i-H iH iH rl i-H rl iH iH lH rH iH rH rH rl iH iH i→ rH i→ iH rH iH iH iH rl i m ro co oo co co ro oo fo oo oo oo oo oo oo oo co n oo co oo ro oo oo oo oo ro c co iη ro ro c oo co ro oo n oo c iη υ c cj u υ cj cj cj υ c u o υ u cj cj cj υ u υ u υ υ υ u u υ o c cj u o u c cj cj cj cj cj cj u cj c u u u υ o υ o cj o υ cj u

Cxl Cxl D n D D D D D D CO CO CO CO CO CO CO CO CO OS OS oS cS OS oS ClS tf tf tf tf x x x H H H i- Ha Hi i- z z z z z z z z o ps os p os

H i- ω ω ω ω ω ω w ω x x x x x x x x a a a a Ha Ha π H H Hi H Ha tf tf tf tf tf tf tf co co co c co c c c a a a

H H a »j ιi a ^a a ιaa ^ a a Hi a αHi Hi H H EHtH tHSH tH«ι; tf tf tf CJ CJ CJ ⁽J > > > > > > > tf tf tf tf tf tf tf tf EH H EH EH EH rl CM rl CN rl CM rl CM rl CM tf CQ Cj α α tf CQ CJ Q ω CO tf CO CJ CJ tf CO tf tf CQ CJ CJ tf CD CJ Q Q tf CQ CJ CJ o o z υ o cj ooo o z υ υ u υ c z c o z o o o υ cj o z υ υ υ o z cj o o z o υ cj u υ o z o u υ o z cj o z υo o cj

^ tD ^ N CN' « ^D O (^,^ ri ω (! [^ι r^ ιn <Jl ^o ι o ^o ^o o ^ ιo ^ N H ι¹l ^ ^ <l^, ln cD ω o o ιf) ^ c>^ c ri r- co co cM O Co cn cD r cM CD ^ Ol σι H m o o ιn "I m ω ιo n αl ^ (^l H ri ω N J ω tΛ ^ N ιn ^io w cD H r• σι σ^ lJ^ to ι oJ N σl rι oo cM in i" p-- cn cn o cM CD ιn r ιi' in oo in σi co cD oo en in in σi iH in rH in r^ o oo o co oo oo ir ri cN ri ro ri oo O 'tf co cn o co oo cD co oO ri co -tf in co o o ri o cri σi cn cM LO m m "tf 'tf oo cN co in co m u3 in in m ⁱtf r-~ oo r~ r~- r- m 'tf co cM cn o cn O O CO CO 00 CO o O o en oo cn o cN CN CN co ro cN CN C CN 'tf LO i' io io

OD OO m OO OO OO OO OO OO OO OD OO OO rO CO OO OO OD OO OO eO OD OD OO OD T OD ^■tf f CO OO 0000 -stf H* lP 0 O0 D ^* ^¹ 'tf "tf 'J¹ "tf 'tf 1* 'tf 'tf "tf U¹ 'l¹ "tf " rl rl rl rH rl rl rl rl rl rl rl rH rl rl rl rl rl rl rl rl ιn n ^ N ι n N (i ^ ιD ι s H ω ιD H ^ ιn co ιD (ι o H ■ϊ m o ι» ω ^^ ^ ω ^ ^ N oo (D <f O ^ O 'J ro "^ι "l' ln ^ ω ln o co (η o ^ ^ co o o rn ^ ι N ^ ^ <Ji H oo ιn a o <)i ιη N ^ ^ H in θ M ^ m ^ θ (θ ^ rN^, ιη N ^ θ H h H θ iD N θ f^fi H r- (θ ( iC) θ3 iD ιn m <j ιx i^ c c iO uO CD r^ oo oo c iH in ro iH in oo c C Oo cn o c cN ^ ∞ C ∞ oo o cN CD cn O i^

H o ι n 'J ^ l ( n n ^ v n N n ιn ι w ^ ^ co (o σι σι w ^ ιn ln ι v ^ * ιn « ^^ n N H H O ω (^l rt (D n ιn ι w ^ ιn n rn ^O '!f

CN CN CM CN CM CN CN CM CM CM CN CM CN CN CN CN CN CN CN CN CM CN I CN CM CM CM CM CM CN CN CN CN CN CN CN CN CN CM CM iH CN

'tf ri m r- r~ ri o O ri co r- co in in i

os ffl m m m « is m m o o o o o o o o H H H H H H H H H N M N N M N N r N (n n n n n (^,) fO ( ")ⁱ 'i » ^ ^ <j » Hr Hr iii in ui oo oo oo oo oo oo oo oo c M OD co oo oo o oo oo oo oo oD oD oD oo co co oo ro oo co ro oo oo c oo oo oo oo ro co ro oo oo oo oo oooυυυoυuououooυυυouυυuυυυυoυυoυυoυυocjoυcjcjc cj cjcjcjc uuuc cjcjc

Λ a; (iS c- ; Λ p5 cS tt; (!^j iH θ₎ aι (iι a i-ι [- w tn tn n w !n w m w D D D D D D D D D D D D D D D D D Ha Hl H

3C 3* hC 3C 2.-J t-i- ϊ-C CO CO CO CO CO CO CO CO X X X H cxi cxi ω cxi ci i txi i q ^ Hi Hi fa ^ Hi a ia fiK ri; tf tf tf tf tf tf tf tf Ha πa π H Ha H i-a H Ha c cj cj c j cj j CJ 2 2 2 2 2 2 2 2 CJ O CJ CJ CJ CJ C3 CJ CJ > > > rl CM rl CM rl CN rl CN tf CQ CJ CJ tf CQ CJ Q Q tf CQ CJ Q Cxl CO tf CO CJ Q Cxl Cx] tf CO CJ Q Cxl tf CQ CJ Q Cx f

CJ O Z U O O O CJ O uuuoouo z υ o u o o z oozcjcjuυoocj oz uυocoou o z oooυol Coxloozo toCQ ln ω ^ oD m o H l ⁽D ^ ιn Φ ^ oo m o H N (D « ιn ω αl Λ O H ι π v ιn w ω o^ O H ^ι t^ ^ ln w ^ ω Λ O H c^ι n ^ ιn ω ^ m m ιn ιn ι ln ιn ω ιo ^D ls ^o ω ιo Φ lo ιo ^ ^ ^ ^ ^ ^ ^ ^ ^- ^ co ω c ∞ 03 m ω ω ω ω m cn m m m m m w c^ι c^ι o o o o o o o o o o OO OD OO OD ΓO OD OO OD ΓO OO ΓO OO OO OD OD OO OO CO CO OO OD CO CO ΓO OO OO OO OO OO CO OD OD OO OD OO CO C O oo oo oo ro oo oo oo oo oo oo ro oo co ro co oo n oo oo co co co n ro oo oo m oo oo oo oo m n n oo oo oo oo oo co oo ro oo rH

2oo2o22o2oo2o2o22o2o2oo2o22o2o2oo2o22o2oo2o22o2oo22o2o2oo2o22oo2o22o2o2oo22oo2o22oo22o2oo2o2o2o2o22oo2o2o2o2o2

© fttf tf tf tf tf tf tf tf tf tf tf tf tf fttf tf tf tf tf tf tf tf tf t_f tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf t_f o

in O lΩ r- oo cn "tf CO CM ιo ιθ N OOO OOO tnιn(^l!Λot>^ HOl n ιn ιn ιn

^ (n (N ^ ω ιn H d co ^ ^ ιx) ^ 0 (η ιo σ) ( <) ^ n ^ N n m l H O ιn ^ ts w o ( O ^o ()1 ^ [ » m ιJι ^ m ιfi H O O H <l' lo m co o ιn m ^ ^ H ι Λ (^ H (^ι <Jl lIl H m ιo l ω oo Φ H lO H H ^ o n o n H ^ o ^ ^ ιη N lo m ^ ι m ^ ^ W Hl' O co (n cD ffl lD ιn p^ o ιn v ιIι ^o o o N ^ ι» oo ^ ^ ^ o ol ^ t^ ^ ^ ι ω ι n ιn ^ v ^ ^ o ^ (η σι (η o 'J (η N m ^ cl N H l5l o ^■ 'f ^ o f^,^ ι o ( 'J r- o ^ m m c) o^|l (^l H lJl co t^ι ^ H N H ^N^■ (^,^ "f m ιn ^£ι ^£l H O ri O l)l co co H'H H N C H O H H i H o cM Oi co m oo oj i m Mio io in Hi' i' ^ cn M θ ι→ ι-H σι ιo ιn cD CN CD ri cD i (xι cN 'tf CN cη o r~ "tf co D σι o r o o ιn e <τv c ^ [~ CM co r-- r~- o '.D cn co co cD i-^ cM oo 'tf c cM in cri io eo cn o ιn r~ cD cn 'tf r-~ ro cn ιn 'H oo co o ^,tf c ιn r~ θ 'r oo c c cn 'r ιn cθ rH co r o ιn r- "tf ri ri oo ■tf o i o n" O CN r- oo r- o c rH "tf CD

O CO ιn CD 'tf r Oθ r-~ OO ιH OO ι^ ιH O ιH ∞ rH rH CO CD CN CD O CM O O ι^ 'tf ιH 'tf Cn oθ Cn o in Cn cN r- CO σi co o co ri cD in co cM C p- o c 'tf o

[^ r- r~ cD r~ cD CD ιn ιn cD ιn ιn "tf θ eM CM e o eθ (^ C ιH C ιH CM oo c cN θ o co r~ CcDo rr--- ccoo ccDo CιDo i' Cθ τ cN CD CD r- oo oo o cn ι-~ co r-- r~ ιn cD oo ιn ιn ιn ι ι ιn ι ι ι ι ιn ιn t ιn ι ι ιn ιn ιn m ι ι ιn ιn ι ^ m ln m Ln ^^ 1^, ■ϊ ^,3^, ^^, "l^, ^ 3* ^* ^^* ^3^ ^* ^3* ^3* ^* l ""^f ^3* *^f ^* ^* ^* ^^, '^

ιn ιn ιn ιn ω ιo ιo ιo ι^β lD ιfi ιo ^ ^ ^ ^ ^ ^ ^ ^ ^ ω oo ω o^ (! Oo ω ω m cn c^ n m o o o o o o o o H H H H H H H N f^l ( N r^ι

CN CN CM CN CM CM CM CM CM CM CM CM CN CN CN CN CN CM CM CM CN CN CN CN CN CN CN CN CN CN CN CM CN CN CN m oo oo oo co oo oo oo ro oo oo co oo co co oi co c oo oo oo oo oo c oo oo co oo co oo oo co co ro oo oo oo oo oo oo oo oo oo eo eo e^ o o υ o o o u o u υo o cj u υ u υ υ υ υ υ υ cj o υ υ o u υ υ υ υ u o o o υ o o u o u o o oo o oo cj cj υ u o c a a j D D D D D D D D w ω w w w w ω w to n D D D D D CJ rt) «( W CU til til U I-l tLl Kl H H H H H H H H H H z z z z z z z z ..a os os os os os

Cxl Cxl PS OS S PS co eo co co co co co co

> > > _H ι- ι-a Ha H Ha ι-a ι-a a a a a a a a H! a a HI H! ι-a ι-a tf tf tf tf tf tf tf tf tf tf tf tf rl CM rl CM rl rl CN rl CM rl CN rl CM o c tf CQ CJ Q Q tf CQ CJ Q Q Cxl [xl tf PQ CJ Q Q tf CO tf CQ CJ Q Q tf PQ CJ CJ tf cα CJ o c o o z CJ υ υ o CJ o o z O O O CJ Z O Z O O Z O J U O CJ CJ O Z J o o o z υ u c o z υ o o u o U CJ o z υ CJ o CJ ^ ω (Jι o H N fO <J ιn ω ι^ co m o H ^ (η ^ ιι^ w ^ (o tIι o H N ^o ^ OO OO OD 'tf '^ 'tf 'r co co oo co M 2o222 22 EoHoEHoEHo222 EHoEHo2 HoEHo2 EHoH Ho2oo2 EH Ho222 EHoEHoHo2 EHo2222 o2222 EH HoEHoHo222 EHoHoEHoEH EHoHoEHoEH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

^ "J H W co σι m rn ^ ^ ^ o ιn m ιJl O 'ϊ n ιn c^ι H O ^ m n N '* ι u⁾ n l ^ H ιn (η σι ^ ^ π ^ o ^^ ^ σl o ^^fl o ^ ^O r^ ^ ι N m ^

-a o ιn c c co co ri c c oo ιH r cM o cD ιH ri o co ιn ιn cn ιH r^ o r~ cM CM r~ cn cN rH -tf ι~ 'tf r-- cD r^ m 9 s c -tf in oo cM ro c 'tf "tf in ιn 'r 'r r co o cN CN CM θ co co θ 'tf θo ιn o cn ιn -tf rH ιH σι co ιr ιn cM o σι θ rH cn cM ∞ ιo co co co r- r-- c^ r^ r~ r^ i" co i" io co r--- r-- r- r~ co ιo ιn ιn ιn ιn ιn ιn ιn »tf

© ©

CΛ ooooooooooooooo o_ o_ o_ o_ o_ o_ oooooooo o o ooooooooooooooooo o o o o o o o o o o o o oooooooooooooooo oooooooooooooooooo ooooooooooooo

H rl rl rl rl rl AH ι ^ O H O ^^ ιn M O ω ιl) ι ^ Λ 'f m ■J ιn ιo ^ W H "T (D ln ιn ιo ^D co oo n ω H ιn ιn 'J ω o c^ι n^ n ιn ^ ^ H N W ^ oo ^ ^ ^ "ιr (^,l ιJl m o H Λ m m (o ^ ^ ω ι ^i) H ^ Iη M N ιn ιn "a^, H W (^l ln n ^ >J ^ H lo ιn N N H ι o ■ϊ ω ιn "^ ^ ( O ιn o ι oa ^o ffl n m cι co oo cn o c 'tf in r^ co cn r-- co r"- co co co 'tf c c CD in ι oo ιn ι ιΛ CN "tf cD r^ m o o N n "τ tn ιn ^ ιn t>o <Λ ro ^ ^ ^ w w ιn ω ω Φ Λ Λ « o^ ι ιD ιn ω o ιβ ^ ^ ιD lfl ιΛ "f "f ^ v ^ ^ M N (O H H ι (η n H H ijo co co ιo <o co <x> ιo co ιo ιn -o ιn u ιn ιn ιn ιn ιn ιn ιn ιn ιn Ln ιn ιn ι^ cθ "tf r^ σι cri "tf -^ oo cM "tf co c ιn ri c cθ "tf io σι c cD o oo cN oo oo o co o cD ( CD c 'tf θ ri cD O rH CM CM c— oi oo o r~ co -tf oo o oo oo r- "tf oo CN CM -tf cn oo ιn co ι^ o ιn cM r~ P~ co cn ιo co o ^ cn oo cn oθ 'tf iD rH ro r-- CM θ r-- ri θ Ln cM CN CN in co eo cθ ι-H "tf 'tf θ 'tf c- r--- co oo cD oo oθ 'tf θo (η r~ r-- oθ 'tf co oo rH 'τ ιn oo c Cθ co r^ o co o co c co co r oo c ιn Ln c r-- o c Ln θ ri rH CM cn ri ri CD m σo σι r~ ')^, o cN CM r-- o oo co ro oo ιn

T CO CN rH CN ri rO CN ^ OO rl rH rH O O rl rl CM rl rl O CN OO 'tf 'tf i> m co ro oo cM CM CN CM rl i-H O rH rH O O OO CO O CN rl 00 00 LO "tf -"tf 'tf rl rl rl rH rl rl rl rH rl l-H rl rl rl rl rl rl rl ιn o co co o ιH co c o σi H in oo ι c ιo ιn oo ιn o cM CM CD oo σi ιH ιH H r~ r~ c co c co c c co cM co D r^ oo cM C^

H ()^ "I « ^ o ιn H ιn m n ^ o o m ■J m ra ^ o » ^ oo ^ N ι (η w ιβ (^l H ^o w o o m m ιfl ι ω ω ιD m oo α ^C r^ n^ H "^ o {η r^ H O H ^ H t ι^ H lD (^l "^ι c^ι r^ ^ 'ϊ H o m ιn (n ro ω o3 <J N N N t^ι (l n w v <l^ι o ffl w ^ ω ω ^ o o H ffl N « (Λ ω ω ω "f o ^ v r^ r- oo oo oo oo oo oo oo oo oo o co oo r~ ^o m oo m oo o σι o o cn cn oo cM oo cM co oo -^ "tf in co r~ r~ oo cn o cM n cM 'r cn oo oo cn co r--. ρ-- ιn co -o in -tf i in 'T 'tf ^i' i Ln in i in Ln in in in in in in Ln co cD iD iD cD Ln in in in L i in in in i

CN co o c oo o oo c oo o r θ 'tf '" " ' "tf "tf ''i' "tf ' tn ιn Ln ιn Lθ ιn ι ιn cD i^ co co ro co oo co co co (^ c (^ r oo ro co (^ (^ co c oo oo oo oo oo oo c co oo ro oo oo oo co ro co co ro co co oo oo oo oo oo oo oo oo ro co n oo oo oo oo co n oo oo oo oo oo oo ro co oo ro co co oo oo oo m co oo oo oo oo oo oo oo oo oo n oo M υ υ υ υ ucj υ u υ ou υ oo o u ocj υ u o υ o υ υ o o u c u o υυo o o o cj u c o c υυ cj υ υ cj u υ cj u o u υ os ia ci cxi cxi ω ci ci ω cxi xi i D D O D D D D D D OJ OJ CLI CM CM CLI C CI-I D D D D D D D D D PS PS OS PS PS PS PS OS ωaaaaaaaaaa a co co co co co co co co Hi j j j j a j Hi J x x x x x x x x

CO CM C-j C CM CU PM CM CM CM CM CM O CJ O CJ O CJ CJ O tf tf tf tf tf tf tf tf O CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ EH EH EH EH EH EH EH EH rl CM rl CM rl CM rl CM rl rl CM CM tf CQ CJ Q Q W Cx] CO tf PQ CJ Q Cχl Cxl tf CQ CJ Q Q tf CQ tf tf PQ CJ Q dl Cxl tf PQ CJ Q Cx] Q CJ Z O O J o υ υ υ CJ CJ o u υ cj c oo c o υ CJ o o o o o z O O O o z uυozooouoooo z υ o o o υ o o ιn ^B ^ o^{) (}^ O H ⁽^ι ιo ^ ιn » ^ co ⁽⁾^ O H <^ι m ^ ιn ^ ^ co Λ O H (^ι Λ ^ ιn » ^ co o o H N r^ ^ ιn ^ ra (Λ O H (ι Hl' ιn ιfi ^ oo o^ ιo ω ιfl lo ιo ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ co tD ω oo oo ω o ω ro ∞ m m m α m ι3l σl (!l m σι o o o o o o o o o o l H H ri H H H H H H "tf ir ^ -'r "tf 'r ιr 'r ιr 'tf "tf 'tf "tf 'i¹ ^ "tf 'tf " 'r "tf "tf "tf "tf "tf 'tf "tf 'tf "tf "tf '^ ^,'j< "tf "^ co co oo oD oo oD oo oo oo oo oo m oD oo oo oo co r co oo oo oo ro co co oo oo eo oo oD oo oo oo co oo 2o2 2 2o2o2 2 2 2 2 2 2 EHoHoEHoH H EHoHoHoEHoEHoEHoEH

H H H H^ ι-3 ι-. H >-3 H H H '-3 H^ H ι-3 H^ H^ H^ H^ H^ H^ H-3 H^ H H^ H^ H^ H3 t-3 H3 H3 H H H ι-3 H H ι-3 H H l I-THI H H ^ ^ ^ H ^ H H H H H] ooooooooooooooooooooooooooooooooooooooooooooooooooooooo

ω ω ω ω u ω ω w ω ω ω Λj ω ω un u-i cji uπ uπ ui ui ui ui ui ui ui ui ui o o o si o m σι m m » cn oι m m ι U ) O lO ffi θ m l Λ l. W μ m W fc ω o o π o o π o o o o o z o o z o oo o z o O O CΛ O O O O Z O O O O o o Z O O on n u GO CO > σ σ <D co > D CD (D CO > o a o to CO n to CD CO

CO r¹ > z o o o o z o o o o n o

D > CO r¹

H H H H H H H [O (n 0H/l K tfl > > > > > > > t-^| t-^| t t-^| t-^| t-^, t-^| t-^| n θ π θ n ι-3 H ι-3 H3 H- H3 H9 H3 β H3 H3 lr tr i^l t t-^| t-^| t-^| Pi W Pi M n w co cn co co co co co co pi pi M W Pi κι p3 pi H ι- H< H< H< κ; 3; a a a κ H< H< H ra H M rø w n w sσ po ^ja po so so z z z z z z G a G c a G a G c cn o c n c sa po so so po po so to jo po po ooooπoooooooooooooooooooooπoooπnoonnonoooooπooooonooooo ω ω ω u ω u i ω ω ω i u ω ω i ω ω u u u ω u ω ω u ω j ω u ω ω ω u ω ω i ω ^

J O O O J O O m iΛ lJi σi a m n W W U Ul W W l ι-- ι-ι Λ ιl- ω ϋJ (J U U W M K) N) M N) M M M |^{H p} |^H |-^l O O O O O O O lD lD lD lO

^ ] ^ ^ o o o o o o o o o o o o ^ o ^ m cτι (Λ (^ (^ cΛ o^ σ^ cΛ σ_\ σι σ_\ σ^ σ» {jι σi (yι θ^ {T_\ (Λ θ o^ (^ σι σι σι σi (^ ^ crι i^ σι uι cπ

Ui l m θ OI Uι ft I W U M ^ P P P W U N I-^, O O I- lO lD ffl \O OII M O m * Oi Λ ω ι» * Uι * Λ W W ft W W H N ft W N N H H O U Λ ι θ ιt>ui N) ι--N i£) υι cn σι ω>J N l ιi- co ui (ji ιi- N M o o ro co cn ~J Ul ^ ffl tT_l O Λ H M U l003 σι U1 ιt> lj) tιl O O 00 ω θ lD ω ώ l

Uι ω iClM H OtjJ lOlCi ιt_' I H IM _^J υι Λ |J) ι_^, lβ ι-. o ra P σi ui H M ω ω u o o -ι ι.^j o _ M_ ω_ o3 uι u *> o c fe o ijι M uno p *> i W i u m en M Λ ui H oi Λ m ui o o oo o io m H w ω ^ w iD Ui O H ft O UI i-' OJ I U P O i-. lfl lB J o p -J m m σι oo u uι uι ιθ ιii ιi' Ui -J θ θθ tJi oi ii- ω ω M M O H ω M M ω M t -J ib ui ui J-. M5* l »- ιC ι-- ιfc. /l o μ o ui o m vo to iD co o Λ ffl ui u o ro ic iD O fc M σi M ^ m M o o Λ O Ui i σi iD M co i ω ω j ω μ ω Λ M iti P σi ui it' io o u ι IoD Oo ωUI ωU ιlθC P NN} Pr^, lιoO θO rP' Nto oO oO lωil ιlCo tcΛll NN>) ∞ co θD ∞ uπ uι -J ω c ιo ^ --J o O oO αCOj ωJ oO φCD oOoO cOoO oO MfO cCoO oCOs oCOiJ iOjOi cOtOi oO oO oO o oi p ^ m ^ oi Nj w iji m w M iji i tΛ O o oi fc W Ui ω ui o w o io fc ^ oi oi o fc O i u I-H r' ' ' ' ' r' r' ' r' r' l-π r' r' r' h-' r' H» r¹ r¹ l-¹ r> ' r' r' r' -' r' r' r' l-' r' r' H' l-' H-' l-' H-' H-' H' -' H' ωωωωω ιuuu)(.ωιou iιiuωuωwwuwwω<>*

Ui ω W Ul Λ fc W M N) O O M M J» U Ul Ul Ul ιb ιo. Ul Uι m l (I! 0 0 l-> O r> r¹ M M ib ω M ω Λ Ui σi m ui m o o o oo o cD iD ω H H ω M

.-• _>i ι& u σι M Ui o ui (Λ μ o o ιo o Λ M U uι iD i£i uι ιo o m o w o ω i u ^ ω o ifl Ui ι-- ω ω o σι uι o μ ifl θ θ co M io ω M M ιcι

^ fc μ μ ^ fc Λ O Λ 0!I O I (Λ IΛ l0 J U UI 00 O (J_l O O Λ O O θ μ (Λ W Ul l l CD W 0 C0 ( l -J O U1 ιb Ul M U 03 Ul *> l0 l0 fc U1 l5ι μ ffl *, ιn -j >t» .j ^ σ ω ^ cn o o o o ιχ> <τι c N) -^ W M cn ' ii3 ω o ιfe ^ cD ω o ω ∞ ω r¹ I-¹ r¹ r" H-» H¹ H¹ I-¹ r> l-^H !-^■ r¹ o ooo ooooo oooooooooo o_ o_ o_ o_ o_ o _ o _ o _ o _ o _ o _ oo o o o O o ooooooooooooooooo oooooooooooooooooo oooooooooooooo O O O o o ooooooooooooooooo ω ω i ΛJ W W ω ω ω ω i co c NJ M r' ' C M M c w w c w c M M Nj f iti Λ W ω NJ W M M M I NJ N N) M I N N N) NJ W M N M

U O O O M M M U W IC I M Φ (Λ (tl U flO P W ω M Λ U W H M U N) U Ui sl l ) o co ω ic co ui uni ω o Λ O O Λ i Λ σi in ui ui ω o

Λ ω C0 U\ U1 |J( \C fc ω θ Λ O P M 0 sl ιo 00 lϋ lι) 00 P Λ P 0 U1 (Jl 0 lD O l0 C0 O t. μ i£l l£l C0 Λ UI P U1 O vl J ui os ω ω w o o o u m ui ω o Λ o ω H iJi ω ffl M co H oo o M M fc p io m o cii u w -J o u o ii. ui u io o μ μ m σi Λ O w ui ifl cri M -J lD σι U3 M 01 W O §

table 1

ATOM 3575 O ILE C 347 75.934 10.788 135.716 1.00 34.67

ATOM 3576 N GLY C 348 74.309 12. ,207 136. 334 00 34.14

ATOM 3577 CA GLY C 348 74.046 11. ,458 137. 549 00 33.61

ATOM 3578 C GLY C 348 72.761 11. ,867 138. ,239 00 34.30

ATOM 3579 O GLY C 348 71.953 12. ,617 137. ,678 00 35.47

ATOM 3580 N LEU C 349 72.592 11. ,389 139. 471 00 33.67

ATOM 3581 CA LEU C 349 71.409 11. ,672 140. 269 00 31.92

ATOM 3582 CB LEU C 349 70.572 10. ,399 140. 360 1.00 34.71

ATOM 3583 CG LEU C 349 69.175 10. .536 140. ,962 1.00 38.25

ATOM 3584 CDl LEU C 349 68.296 11. .357 140. ,007 .00 39.99

ATOM 3585 CD2 LEU C 349 68.586 9. .156 141. ,191 .00 37.78

ATOM 3586 C LEU C 349 71.721 12. ,182 141. ,687 .00 30.62

ATOM 3587 O LEU C 349 72.719 11. .795 142. ,298 .00 29.04

ATOM 3588 N SER C 350 70.856 13, .051 142. ,207 .00 28.72

ATOM 3589 CA SER C 350 71.022 13. .587 143. ,551 .00 27.43

ATOM 3590 CB SER C 350 71.590 15. .001 143. .515 .00 26.34

ATOM 3591 OG SER c 350 72.889 15. .011 142. .967 .00 26.24

ATOM 3592 C SER c 350 69.667 13. .636 144. ,204 .00 28.04

ATOM 3593 O SER c 350 68.654 13. .578 143. ,515 .00 29.41

ATOM 3594 N HIS c 351 69.643 13, .742 145. .529 .00 28.26

ATOM 3595 CA HIS c 351 68.386 13, .832 146. .258 .00 28.95

ATOM 3596 CB HIS c 351 67.598 12, .518 146, .162 .00 30.19

ATOM 3597 CG HIS c 351 68.160 11. .405 146, .995 .00 33.01

ATOM 3598 CD2 HIS c 351 67.678 10, ,794 148. .107 .00 33.21

ATOM 3599 ND1 HIS c 351 69.373 10, ,805 146. .725 1.00 31.59

ATOM 3600 CE1 HIS c 351 69.615 9, .876 147, .632 1.00 31.13

ATOM 3601 NE2 HIS c 351 68.602 9. .849 148. .481 1.00 33.01

ATOM 3602 C HIS c 351 68.632 14, .167 147, .716 1.00 29.78

ATOM 3603 0 HIS c 351 69.599 13, .698 148. .302 1.00 31.58

ATOM 3604 N HIS c 352 67.764 15, ,001 148. .284 1.00 29.61

ATOM 3605 CA HIS c 352 67.833 15. .388 149, .692 .00 28.24

ATOM 3606 CB HIS c 352 68.020 16. .900 149, .845 .00 26.76

ATOM 3607 CG HIS c 352 69.436 17. .358 149. .705 .00 27.38

ATOM 3608 CD2 HIS c 352 70.582 16. .670 149. .488 .00 27.13

ATOM 3609 ND1 HIS c 352 69.797 18. .687 149. .786 .00 27.93

ATOM 3610 CE1 HIS c 352 71.103 18. .798 149. .625 .00 27.53

ATOM 3611 NE2 HIS c 352 71.603 17, .589 149. .442 .00 28.55

ATOM 3612 C HIS c 352 66.495 14. .998 150. .292 1. .00 28. ,26

ATOM 3613 O HIS c 352 65.473 15. .043 149. .613 1, .00 30. .53

ATOM 3614 N SER c 353 66.479 14. . ,660055 115511,. .555522 1, .00 28. .24

ATOM 3615 CA SER c 353 65.214 14, .,224444 115522. .115577 1, .00 29, .01

ATOM 3616 CB SER c 353 65.188 12, .761 152, .490 1, ,00 26. .29

ATOM 3617 OG SER c 353 65.387 12, .004 151, .310 1, .00 26. .32

ATOM 3618 C SER c 353 64.995 15, .083 153, .398 1, .00 30. .55

ATOM 3619 O SER c 353 65.937 15, .663 153 .932 1, .00 33, .17

ATOM 3620 N ALA c 354 63.742 15, .188 153 .824 1. .00 31. .52

ATOM 3621 CA ALA c 354 63.391 15. .954 155 .017 1, .00 31. .06

ATOM 3622 CB ALA c 354 62.994 17, .374 154 .657 1, .00 30. .66

ATOM 3623 C ALA c 354 62.240 15, .247 155, .702 1. .00 31. ,47

ATOM 3624 O ALA c 354 61.521 14, .447 155, .082 1. .00 29. ,46

ATOM 3625 N TRP c 355 62.069 15 .523 156 .988 1. .00 32, .19

ATOM 3626 CA TRP c 355 60.998 14, .873 157, .705 1. .00 33. ,04

ATOM 3627 CB TRP c 355 61.538 14, .043 158 .856 1. .00 36, .34

ATOM 3628 CG TRP c 355 60.566 12, .984 159 .209 1, .00 43. .15

ATOM 3629 CD2 TRP c 355 60.660 11, .598 158, .868 1. .00 46. ,13 CN ri oo oo m CM CD rl Cn CO "tf CM r-~ r- r~ m "tf "tf m in m m m in O O OO O O O O OO O O σl ra cn σι σl a) ro oo cD ^ ω ^ ^ oo ιΛ m o N ( (η "J C^l N (ι cJ H C O 'ϊ "J "if ω ^ ^ oo ^ ^ ιn ^ ιn ιn u ^ '» ln ω ιn ^ «) ln ) OO.CΛ ιn ιn ιn ι ιn ιn ιn ιn ιn ι ιn ιn ιn ιn ιn ι ι cD io ιo ιo cD io cώ iD iD cD io <o iD co ^ co cD CD iD co co >Λ oo TO iH rH iH rH iH iH rH iH iH iH iH iH iH rH iH iH iH rH rH iH iH iH rH H iH iH rl rl rl rH rH rl rH i-H rl rH rl rl rl ^μ r- H r~ rl

^r co ro cN oo oo cn σi oo oo ^i' r^ r- co ro co in i' ro oo σi in cn cn r^ ri r~ oo r~ oo cn ιn cN θ θ r~ cn cn r-- co O co oo o oo cO 'tf OO CN i' i— I 'p 'tf r— cn m _"tf _"tf r~ o o co H cn (-- cM r~- c oo cD "tf iD cN σι oo cM cn ι-H r- o r- CN rl rl CO rl Cn 'tf CO O rH OO LO o m oo cN CM co ιn m cM CM θ ro m ι-- r^

T CD r0 CD CN «tf ri σi rl CD ιn 'tf 'tf O 00 σi 'q' O -5I^, 'tf C000 rl CM O C0 co oo oo cO -tf r^ rH CM m in oo oo o r- o cM CN co ιn co o ro ι< cn o <o r^ crι o oo i en oo cn rl O 01 O 00 r^ CD in 'tf in CD CD r-- C0 r~ <X> CD U0 in 't' CM rl O rl CN CM rl rl CN 00 "tf r0 cyi Cn f «tf < ι cn oo o cn cn oo oo oo oo o oo m co in in m o vD in cD ιn ιn Ln ιn ι Ln Lθ Ln Ln Lθ Lθ i L in ιn ιn ιn Ln L ιn ιn ιn ιn ιn ιn ιn ιn Lθ 'tf "tf I-H rl O O O rl O O O O O O rl O

Λ ιΛ ιn ι ι ι ιn ι ιn w ιc ιD ω ω ^D W ^D ^ ^ ^ ^ ^ ^ ^ ∞ a) oo ω co ω oo <Jl lJ σl σι m m w m Λ σl C^ m m σι (Jι o o o o o o o H in in in -O LO in in in in in in in in in in in in in in in in in tn in in i^ n n ^pi n iη n n n n tn n n n π n n iη iη f m n n iη n iη to t tn π n n rn n n t iη t'i i'i n H H H ri H ri H ri ri H ri H ri H H H υ u oo υ υo oo υυ o o υ υu u o υ υ υ υ υ υ υυ υ υ u ou o υ u cj c u υ u Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q

^Qj 0. aι ^Qj CM C-ι C-. CLi C-ι D D D D D D D D pS p pS S oS oS oS H Ha D D D D EH EH EH EH H EH EH H O O O O O O O Ha PS S PS PS PS PS OS CS PS W W W W U CII C-I cxi a a a a a a a tf tf , tf tf tf ω c^χ] C^χi W [xi [^χ] ω [xi Cχi cχi ω ci cχi cχi χi Cχi S PS ps oS pS PS c-; tf

H H tH E< H ti H H ri a ιa Hi a a a a tf H D D D D

J H EH H H EH EH EH > > SJ H i-l > > Hⁱ a a a Hl J J Hl 22 22222 S (- (iι (iι C» (- (, flι >

CM 00 rl rl CM 00 CM rl CM rl CM rl CN rl CN Cxl Cxl Q Cx] CO O a tf co J Q Q tf CQ CJ O tf CQ CJ CJ tf PQ Q ^Q PQ CJ Q Cxl Q tf CO CJ υ o o z u υ υ u o z υ o u O O O o z o oo υ o o o o υ υ υ o z o o o o o υ o υ o co o υ o z z o υ o o u o z

O H N (η ^ ιn « co σ\ o H ι n f ι ω ^ m m o H N M "J ιn a ^ ffl Ol O H ι (η 'r ιn » ω Λ O H (^ι n ^ ιn ^fi ^ oo (^ι O H l ιη Nf co M oo oo c ro o ' 'tf 'tf 'tf '^ 'tf 'tf 'r -'r 'H LO in tn O LO LO tn L i LO co ω

SΩ SO SO SΩ SO ^ SO SO SO SD SO SO SO SO SO SO SO SO SO SO SO SO ^ SO SO SΩ SΩ SO SO SO SΩ SO SO SΩ SΩ SO SΩ SD SO SO SO SO SO ^ SΩ SO SO SO SΩ SD SΩ SO SO SΩ oo oo oo oo oo c^ oo oo oo oo oo oo c ro oo n M oo oo c oo co co ro oo oo oo oo oo oo oo oo oo co oo'co oo o co co

00 rH

V©

2 2 2 22 222 22 O O O O O O O O O O o o tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

Tf

"t_{f C}N -t_f ro _ri o ^ oo r oo m o cD in o cM in o cn r- CD O ιn t^l CD CM "tf "tf O rl oo o o o oo en en r- T co oo o c oo rH CM 'tf m o co m oo 'q' ri f. s _ri r-~ cn o o 't_f CM in cN o m ιn ιn cD σι o ^ Ln oo cn ri m rl OO rl rl OO rH OO 'tf θ ri σι m ri ri "tf c cN 'q^, r^ cM in c oo oo oo o σι o ^,tf r~- rH o

© S ri cn r- rl 00 OO r~- LO CO "tf CO CN CM o σι oo r-- <x> 'tf ^i' eo ^,tf 'tf co ιn co σ) co r-- ιn cN oθ ri ιn cM CM ri ro cM oo oo co o o o o CM ro in co in "tf © LO "tf -^ m "tf "tf i" ^ ^ ^Ηtf "tf ^ϊ¹ ^ 'tf rO OO OO OO OO OO OO OO OO OO OO OO OO O OO OO OO OO CO OO OO OO OO OO OO OO OO OO 'tf 'tf 'r 'r

CΛ ooooooooooooo oooooooooooooooooooooooooooooooooooooooooo

H ooooooooooooo oooooooooooooooooooooooooooooooooooooooooo υ rl rl rl rl rl rl rl rl o LO o in T 00 T rl O o 00 T r~ oo ri o i r~ in o r- *o θ Lθ θ "tf ro oo ^r' ro r- rl o r~ ri in O 'itf Co co cD oo cM VD 'tf ro in m oo ro o o oo cM co

CM r- 00 00 CO r- rl 00 o o o ri m CM co o ro ro r^ cM co o c m ^ oo co c i¹ r- r- cn ri cD r~ r~ ri oo oo -rι< oo oo ιn o oo cθ 'tf cn 3 o rH r- ri rH iD cn ιθ rH CM oo cn r ιH ro cn cn o r^ ro o cM in "tf r-- ri cn oo cn "tf ri co ιn cN r~ r~ rH Lθ r- rH 'tf crι ro oo cθ rH -tf rH m ro co co m m ιn r- θ '>tf "tf ri iH CN O CM CN CM CO 'tf Ln in in in r- r^ r~ oo oo oo oo oo oo cD D oo oo r-- co o o C 'tf ^r ^r ιn "tf "tf in ιn ^ι^, m cN CM CM CN ri cM θ oθ 'tf Cθ cθ Lθ cji σi σi σi σ^ σ^ σi cn cn cn cn cn cn cn cn en cn cn cn cn cn cn cn cn cn cn cn cn o o O O O O O O O O O O O O O O O O ^r O^ 'O~^, 'O-^{, ,}O^_, 'O~^, 'O^_, 'O^-, 'O-^, rl rl rl rl rl rl rl rH rl rl rl rl rl i-H

(^ι ^ O H 'ϊ H Λ ^ ιD ιo (η ιη ι ^ι o oo H O ιΛ ιn ω (Jl (η σι H H o ^ι n ιn o ( m ιn ^o ιn t^i π N N O ι ^ H ιη o ιD σι fπ ^ fη (D o H (n n ι H n ω ω M co ιo m n ^ H oo ιη co ιn o o o m H o o^ ιΛ ^ (<l σl ι ιn ^ (D ^^ ^ (»l ^n ιn ιn ^ o ιn o ^ H m m ^ ^o u^ ιn co ^^fι r^ cD ιn '^ 'tf r^ ιn r-- ιn r~ cD "tf C o co cN 'tf ι cD σ> ιn <-O r^ r o r 'α' r-- σ^ oo oo oo (^ σ ^•^ ι^ o c co r c^ r— co co cn co iD in 'tf ro m iD in 'tf co in 'tf CD ιn r- r~ oo oo o ι-H ri cM CN θ oo cn co oo oo r-~ r~ ccoo cooo co m m r~ !-H rH CM OO "tf ' O 'tf l-0 00 'tf LO CO rl rl rl rl rl rl rH CN CM CM CN CN CM rH rH rH rl rl rl rl rH rl CN CM CM CN CM CM CM CM CM CN CN CN CM

"ir H ω ω σi σi ^ m ω m N in in ω o ω w H oo ^ ^ in in oi o iΛ Λ W ω m i in ^ oj N ^ iTi ω ^ ^ co ω cri Λ H H N N r^ ω ^ in t N H ( O Φ ^ ^ o μ ιn m ιn W {D O O Φ W ιn Φ ln ι "f ιn oo l eo o ^ w w w ιn o ι r- 'il^, 0 (^ι ιD H lI) σ) N H lD t^ ι N σι » ^ m n o H ^ o ^ ^ ω ιD ι ω ω ιn tn ιn ω (η H ^ ^ ( ω ^ m ^ N O o ω ^ c^ι c^ι ^ ω ^ (D ^ O H co N v o ^o - o l H ιn o^ rι (n ιl) •!l' 03 ^ (<^ cn cn o o oo (~ oo oo oo co <-o co cn cn cn cn co co co o cn r-- ιn ιn o oo ao oo r- r- σ» o cn cn co co

O O rH rl O O O O O O O OO OO OO OO OO OO OO O l-H O O O O rl O O O O O O rl O O O O

H H H H H r^ N N N ( N n n r n n n n ^ "f ^ 'H^ 'r "l^, ^ ^ ^ "l^ι ^ HJ ι ιn ιn ιn ιn ιn l ιn ^n ιn ιn ιn ιn ιn ^ w ιB » ω ω ιi⁾ ^ ^ ^ ^ in iΛ in in in in in in in in in in in in in in in in in in in in in in in in in in in in Λ in in in in in ^ in in in in in in in in in in in in in in in in in ui

H H H H H H riHH HrlH H HHrl H HriHH ri HH rlH ri H H HH HHHH HHH HrlHHHH H H HHH Hri Hri H H Q Q Q Q Q Q Q Q Q QQ Q Q Q Q Q QQ Q QQ QQQ Q Q Q Q Q Q Q Q Q D QQ Q Q Q Q Q Q QQ Q QQ QQ Q Q Q Q Q Q

H! ι-a .4 33 O C£ CI; CM C-; O C-; CIS PS C£ C£ C M C-I C M M tf tf tf o PS oOS oOS oOS oOS oOS oOS x x x x x x x x x x x x oS oS c-ϊ c-l oS oS oS oS oS oS oS pS ps ps a a a a a a a cxi Cxi Cxi cx] > > > > tf3: - CM CM CM CM PM CM EH EH EH EH EH EH EH H EH EH EH EH EH EH EH EH EH H EH EH EH EH EH EH H EH H EH EH EH EH EH EH C CO O rl CM rl rl CM CM CN CN OO rl rl CN rO CN rl CM υ tf CυO CυJ CoJuoz tfuoOo Q tf CQ CJ tf cα cj α cxi α cxi co a tf CQ CJ Q Cxl Cxl Q W ISI i a tf CQ CJ CJ tf co cj o z u o u υ υo z υ υ υ υ υ o u u o c o z oυo u υ υυ z u o υ υ z υ o o υ υ o z υ o o

00 rH V© 2 22 22 22 22 22 O O O O O O O O o O O

© H H o tf tf tf tf tf tf tf tf tf tf tf tf tf tf

Table !

ATOM 3740 C SER D 157 1 11100.. 111111 23.305 107.091 1.00 47.76

ATOM 3741 O SER D 157 109. 389 23. 205 108. 083 00 49.26

ATOM 3742 N PRO D 158 111. 175 22. 510 106. 905 00 48.01

ATOM 3743 CD PRO D 158 112. 209 22. 622 105. 862 00 47.15

ATOM 3744 CA PRO D 158 Ill 529 21. 470 107. 873 00 48.12

ATOM 3745 CB PRO D 158 112 760 20. 830 107. 245 00 47.44

ATOM 3746 CG PRO D 158 113. 392 21. 978 106. 534 00 47.27

ATOM 3747 C PRO D 158 Ill 810 22. 047 109. 259 00 48.98

ATOM 3748 O PRO D 158 111 803 21 324 110 257 00 49.86

ATOM 3749 N GLU D 159 112 060 23 351 109. 313 00 49.77

ATOM 3750 CA GLU D 159 112 339 24 023 110. 577 00 50.29

ATOM 3751 CB GLU D 159 112 846 25 442 110 313 00 51.25

ATOM 3752 C GLU D 159 111 081 24 060 111 448 00 50.73

ATOM 3753 O GLU D 159 111 168 24 038 112 674 00 52.21

ATOM 3754 N LYS D 160 109 916 24 095 110 803 00 50.21

ATOM 3755 CA LYS D 160 108 624 24 127 111 493 00 48.11

ATOM 3756 CB LYS D 160 107 612 24 890 110 625 .00 47.76

ATOM 3757 C LYS D 160 108 088 22 714 111 803 ,00 46.25

ATOM 3758 O LYS D 160 106 895 22 534 112 065 ,00 45.85

ATOM 3759 N MET D 161 108 973 21 721 111 793 ,00 44.07

ATOM 3760 CA MET D 161 108 570 20 337 112 033 00 4 411.9 944

ATOM 3761 CB MET D 161 108 721 19 531 110 743 00 41. 0 099

ATOM 3762 CG MET D 161 108 422 20 324 109 491 00 40 86

ATOM 3763 SD MET D 161 108 201 19 267 108 062 00 41 70

ATOM 3764 CE MET D 161 106 479 18 779 108 274 00 40 72

ATOM 3765 C MET D 161 109 376 19 656 113 128 00 40 13

ATOM 3766 O MET D 161 109 080 18 532 113 514 00 39 25

ATOM 3767 N GLU D 162 110 394 20 339 113 624 00 39 93

ATOM 3768 CA GLU D 162 111 249 19 777 114 656 00 39 97

ATOM 3769 CB GLU D 162 112 330 20 803 115 035 00 41 29

ATOM 3770 C GLU D 162 110 504 19 276 115 912 00 39 38

ATOM 3771 O GLU D 162 110 942 18 317 116 555 00 39 93

ATOM 3772 N LYS D 163 109 387 19 912 116 256 00 37 75

ATOM 3773 CA LYS D 163 108 601 19 519 117 430 00 37 57

ATOM 3774 CB LYS D 163 107 739 20 699 117 879 00 38 91

ATOM 3775 CG LYS D 163 106 685 20 375 118 924 00 39 14

ATOM 3776 CD LYS D 163 105 919 21 641 119 271 00 42 01

ATOM 3777 CE LYS D 163 104 685 21 381 120 110 00 42 34

ATOM 3778 NZ LYS D 163 103 984 22 666 120 386 00 43 85

ATOM 3779 C LYS D 163 107 699 18 325 117 135 00 36 24

ATOM 3780 O LYS D 163 106 522 18 499 116 832 00 36 01

ATOM 3781 N LYS D 164 108 248 17 118 117 231 00 35 31

ATOM 3782 CA LYS D 164 107 482 15 908 116 949 00 34 73

ATOM 3783 CB LYS D 164 108 .429 14 .703 116 845 00 33 14

ATOM 3784 C LYS D 164 106 363 15 .627 117 971 00 34 05

ATOM 3785 O LYS D 164 105 279 15 178 117 597 00 33 86

ATOM 3786 N LEU D 165 106 616 15 901 119 251 00 33 62

ATOM 3787 CA LEU D 165 105 .614 15 .668 120 299 00 32 .88

ATOM 3788 CB LEU D 165 106 .266 15 .047 121 539 1.00 30.62

ATOM 3789 CG LEU D 165 105 .369 14 .968 122 780 1.00 29.12

ATOM 3790 CDl LEU D 165 104 041 14 .358 122 395 1.00 30.41

ATOM 3791 CD2 LEU D 165 106 .033 14 .148 123 .875 1.00 28.30

ATOM 3792 C LEU D 165 104 .825 16 .900 120 749 1.00 32.89

ATOM 3793 O LEU D 165 105 .403 17 .880 121 214 1.00 31.55

ATOM 3794 N HIS D 166 103 502 16 .839 120 623 1.00 34.11 rl OO CD in m oo N ιH ooo ooo ι oo ιn ιn o ιη c^ oo H n m n M Λ ^ ( W H co >* o H n o n o^ ιn ffl » ι^, w ^ o p^ c ol H oo ι^,^ (o n (D ιn ^|il ^ ^^■ c^ι o o <J co H l ri ^o ιη H ^ Λ ιn ^ ^ ιn ιΛ Ol ^ o n o ^ H ιo o ^ m o O '» co c ω ιIι ^ ιn (^l H H m o (Jl « (η r• ^^) (D ^D e^l (lO (o <f H r- ι r" H ^!) ^ι ι 0 3l ffl N O H tN N H ^ ω ^ H H ^ ιn w ^ ^ (I) "^ ^ n rt H ιn ι ω H Ol (Λ ^ αι π ^O "» (^ (η ^ m σι ιn ιn o3 (Tι ι£l r^ ιD σι H ^ H v ■* ri oo co oo co r-~ c— w c^ι ιη ^ ιn ιn ιn ι ln ^ ^ ^n ω ^D ^ ^ oo m oo ^ ω ^ ^ ^ ω ^ ιn ιn ιc Hf ^^ 'r rι ^^ c^ι m (^l H H r^ H m co cIl r- σι cn co

CM rH rl rl rl rl rl CM CM CN CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CN CN CM CN ^

O N H ^ n M ^ M ^ H ω ^B o^ m r^ (η ^l N H ^ ^ H (η (N ^C H m ι^,1 ι <Jl σι co ιo w H o^ ^^ n m m ιc> (^,) "l^ι o m ^ m N ^o O H Λ 3 oo ^o ιn ιn o ^O M o^|1 H ^ ^^ ^f| (^l • ι m ^^ M (ι ^^ H ln ^ H O ^ H ^ ■l' co ^o m ■ϊ ιn ^β ι Λ H O O ιn 1' ^ Λ ι cn 'tf ri ro LO ι l ^ o a (^l (Jl O (D m ιfl (^ι cD ^o ιn ^ H ιn o^ ιIι ^ l ln M 9 lB ι ^- ra ^ (D ^ ιn t N O ^ι oo o o ( ι o o^ H f O tη o cι r~ oo σ> o oo cn o r- CO r-- r~ r~ OO O OO OO O rH Cn cn oθ O CN O rH CM O rH Cn Cn cθ O rl O rH CN CN O O C r "tf "tf 'j' Cθ o ri "tf θ m ιθ "tf o 'tf CM

CN CN CN CN CM CM CN CM CM CM CM CM CM

c H l t^ι π ^^ ^ H o ^ι μ (ι o H Ol (a a) Ol ^ ^ ^ ^ ^• ln ι ^O "^ <l' n cN H H H H O (Jl H O (^l (^,) '» ιn ^ ^ n ol| (n to c H ^^ι ^ ln "» o o o o o o o o o o o o o o i βi iJi Λ tΛ m w ^ σi oi iJi in ^ m oi tΛ cn tJi Λ Oi oi oo cn iΛ Λ W Λ w iJi oi Λ ffl i m Λ Λ fli m σi m oi i-H rl rl rl i-H rl rH rl rl rH rl rl r-l rH

w ^o ^D ^ ^o ^fi ^o « ιo ^ ^ ^ ω llo oJ oo m ∞ co Ol ffl m lΛ m m m o o o o o H H H H H t N N cl N M ( l N N r^ (^,) to ^^ ιη f^ (») ^ co cD io io i o co io o cD CD co vo cD CD iD CD co co cD CD CD CD CD Co i cD io r~ r~ r-- r^ r~ r-- r^ r~ r^

Q Q Q Q Q QQQ Q QQQ QQ Q Q QQ D Q Q Q Q Q Q Q QQQ QQ Q QQ Q Q QQ QQ Q Q QQ Q Q QQQ Q Q Q Q Q Q co c co co co co c co o tf tf tf tf tf H H H Hi H H Ha o o o o o o o tf tf tf tf tf tf tf tf tf co co co co co co co co co pS oS PS oS pS oS pS rl

H Ht H H H H Ha Ha π iJ Ha tf tf tf tf tf tf tf s pS DS os os s o H HJ Hπaa Hπ iH-aa πa ^" ι-a ^" HI ^" _HJ X X X X X a a a a a a a a a tf tf tf tf tf > > > > > > > CM CM CM Pj c-ι c-ι cι tf tf tf tf tf tf tf tf H4 H! π ι-a r a Hl Hl EH H H H H H π σι !r ∞ se o 22o2o2o2o2o2oo22o2o2oo22o2o2o2o2oo2o22o2oo2o2o22o2o2o222222222222222222222o2222222

H EH EH EH EH H EH EH EH H H EH EH EH EH EH H H EH EH EH EH H H EH H HoHoHoHoEHoEHoEHoEHoEHoHoHoEHoEHoEHoHoHoEHoEHoHoEHoEHoEH HoEHoEHoEHoEHoHoEH o tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

CM co 0θ r- O ιn "tf rl rH ιn CO CM oo 'tf O » O (0 l»l in N U! >β -'r OOOOOOOOOOOOOO OOOOOOOOOOOOOO

O ri oo cN LO 'i< r~ ro oo cM "tf ^ σl r- co ^ ιfl •* [)^ ^• Hl' ^ι ιn o H ι») α) (IHO ιn o o3 lD ^ ιn H ^ ln m ^ ^D ^ ι«) (M ^^ ιIl lD H ω m o o H lO (n cN CD co r~ cn o r~ co oo ιn rH o e co ( θ ιn r~ rH [^ ri cM θ c o r σι cM oo ιn r- co rH H ri σ^ ^ r-- cD o ιH co oo oθ 'j' rι o oo oθ 'tf ri r o cn oo r- oo ro r- oo 'tf <ri o ^lo rH io cD θ rH CN r Ln ιn cN oo o ιo co o cD p-- oo cD ιn ιn r~ o ^ cM 'tf co c "tf 'tf 'r "tf θ σι o co ιn i cD θ "tf Cθ i oo r- oo ID m in "tf n^^p^(ιc^ι ^ι >^^oιn^£lr^oμ(Jιm<^ιOl^^Dιn"fω^ιn^•'3^,ln^oι»1πNHτ^HOOl(^ι^^ ^oιo^ι "^'tη rl rl rl rl rl rl rl i ri i-H ri ri o o o o o o o o o o o o o o o o o o o o o o cn cn cn cn cn oo oo cn cn cn rl rl rl rl rl rl rH O Cn θ rl rH CM CN 00 rl CN O O 00 00 00 r- r~ C0 C0 O O rl rl 00 O O O 00 o cn oo r~ rl CM CM rO OO rl rl rl O CTl Cn rl CN O rl CN rO O Cn O cn cn

CM rl rl rl

^f (Il o ^ σι ^ι ι ιn oo ^■ c■ rl « o ^Cl "^^| r^ <Il 0 o (η 'l^, ^ "ϊ 'l^ι ^ tO r^ ^ l ^^ ιo ιn o H O '^ ^ lJl ln (Λ o co H ^O N H r^ Ol <ι^ι ^β (^l H ol (n n ^ m v ( ω ^ o ι ιfl H o m ιn n m co ^ ι <I) Λ ιn ιI) r^ n ol Λ (η ^ H t-^■ <l' O oo ι o H c^ι r) o co H ^C H H σι ra H (Il ^ θ "tf ri oo oo o [cMl Hri ιm wvD ιιnn ^r~ ^c> ^ H "r o w o o N N ^O ι^ ^ ^ ιB ιn m « o m '* w ^ Hf ^D ^o aD H (» ιn H ^D (lo N o aι ιIl "^ O M ι ^ m ιo r- co m 'tf r- r~ r^ oo cn oo oo cn σι o oo o oo o o c H i-H C C ro cN ro ro o ro cN ^ ^ "tf in ^ in cD i i cn 'tf Ln ^ co co co co co r- cD co i oo cn cn cn cn cn cn cn cn cn cn cn cn cn cn o cn o oo cn o cn o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o rl rl rl rl rl rl rl rH rl rl rl rl rH rH rl rl rl rH rl rH rl rl rl rl rl rl rl rl rH rl rH rl rl rH rH

"» v ^ ^■τ ^ v ln ln ιn ιn ιn w ιo ^fl ^o ιo ιfi ιc lB lo vD ^D ^ ^ ^ ^ ^ ffl to ω « oo tD ⁽!l t^l σl W O o ⁽Λ o o o o o o H H H H H H l N N r~ r~ r~ r^ r- r~ [~ r^ r^ r-- r-- ι~ r^ r~ r-- r^ r- ~ r-- r~ r^ r~ r~ r~ r^ r--- r^ rl rH rH rl iH iH rH i-H rl rl iH rl iH i-H iH rH iH rl iH rH rH H iH rH i-H rH rH rl H rH rH iH iH iH iH rH iH rH iH r^

DQDQQQQQQQQQQQQaQQQQQQQQQQDQQaQQDQQDQQQQQQQDQQQQQ QQQQQD π Ha co cxi ω ω cxi c-i ω cxi cxi ω cxi co co co xa a co co co co co co co co o o o o o o o oS os cή oS os ciS os oS os oS oS QS X x x x x x x x o p ps o pS oS os ω j xi ω iii i cxi -i ω ω ω ω H H Ha ax^xa a ni baOaiaαiai-iaOi iii αaj Pai QaiaOixa Hxixa Ha πa O O U O O O Cli C-i CM C-i C-i C-i C-i CO CO CO CO CO CO CO CO CO CO CO CO CJ CJ CJ rl CN rl CM rl CM tf CQ CJ CJ tf CQ tf CQ CJ Q Q txl Cxl cO tf CQ tf CQ CJ Q tf CQ CJ t Q CJ υ o o o o tf CQ O f o z oooozooooυuυυυozυυ oozυυoυcozuooυu o z υ υ o u o z υ υ o υ tf o z υ o ιn Φ ^ ffl w O H N ^ ^ ιn ω ^ ω ^ι o d N n "> ln w ^ tD lJl O H N ⁽η ^ ιn ιfl ^ ω o10 H N n 'J ι w ^ co σι O H N (^,) ^ ^n ιn ιn ln ι w ιo ^o ^fl CD ιo ιo ^o ιo ιo ^ ^ ^ ^ ^ ^ ra ro co m c ∞ co m ω ι_l t^ι m ffl ⁽Jι ⁽Jl m m ⁽!^ m m o o o o o OD ∞ OO OO OO OO OO CO OO OO CO CO CD CO CD Cσ OO OO CO CO OO OO OO OO OO OO CO OO CO CO CO OO OO CO OO CO CD CO ∞ oo oo oo ro oo oo oo ro ro m oo oo oo ro oo oo ro oo ro co r co co n co n ro co oo oo ro oo oo oo ro r ro oo m 2o2222222222 2222 EHoEHoEHoEHoHo o 22 22 22 22o22 EHoHoEH EHoHo 22 EH oHoH o2 EH EoHoHo2 EHoEHoH oEHoEH oEHoEHoEHoEHoEH EHoEHoEH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

Table 1

ATOM 3905 O GLY D 182 104. ,697 20. 588 93. ,180 1. 00 47. 72

ATOM 3906 N THR D 183 106. ,184 19. ,421 91. 960 1. 00 A 6. 52

ATOM 3907 CA THR D 183 105. .424 19. ,577 90. ,724 1. ,00 45. 61

ATOM 3908 CB THR D 183 106, .044 20. ,652 89. ,807 1. ,00 45. 40

ATOM 3909 OG1 THR D 183 107. .457 20. .453 89. .725 1. ,00 46. 04

ATOM 3910 CG2 THR D 183 105. .766 22. ,049 90. ,358 1. ,00 44. 85

ATOM 3911 C THR D 183 105. ,339 18. ,251 89. ,978 1. ,00 44. 73

ATOM 3912 O THR D 183 106. .350 17. ,597 89. .730 1. .00 44. ,87

ATOM 3913 N PRO D 184 104. .116 17. ,818 89. .642 1, ,00 44. 69

ATOM 3914 CD PRO D 184 103. .857 16. ,493 89. .049 1, .00 43. ,56

ATOM 3915 CA PRO D 184 102. ,854 18. ,510 89. ,930 1. .00 44. ,95

ATOM 3916 CB PRO D 184 101. ,829 17. ,645 89. .213 1, .00 43. 90

ATOM 3917 CG PRO D 184 102. ,400 16. .271 89. .384 1, .00 43. ,92

ATOM 3918 C PRO D 184 102. ,559 18, .636 91. .431 1. .00 46. .12

ATOM 3919 O PRO D 184 103. .002 17. .806 92. .242 1. .00 45. .37

ATOM 3920 N GLN D 185 101. ,804 19. .677 91. .785 1. ,00 48. .01

ATOM 3921 CA GLN D 185 101. ,439 19, ,942 93. ,179 1. ,00 48. ,94

ATOM 3922 CB GLN D 185 100. ,386 21. .050 93. .269 1. .00 50. .69

ATOM 3923 CG GLN D 185 100. ,407 21. .749 94. .605 1. .00 55. .14

ATOM 3924 CD GLN D 185 101. .796 22, .271 94, .959 1, .00 58. .21

ATOM 3925 OE1 GLN D 185 102. .026 22, .757 96. .067 1. .00 61. .45

ATOM 3926 NE2 GLN D 185 102. .727 22, .177 94. .014 1. ,00 58. ,46

ATOM 3927 C GLN D 185 100. .927 18, .677 93. .851 1, .00 47, .51

ATOM 3928 O GLN D 185 99. .975 18. .049 93. ,374 1. .00 48. .35

ATOM 3929 N PRO D 186 101. .558 18. .283 94, .970 1. .00 44. .84

ATOM 3930 CD PRO D 186 102. .748 18. .894 95. ,593 1. .00 43. .75

ATOM 3931 CA PRO D 186 101. .150 17. .072 95. ,686 1. .00 42. ,59

ATOM 3932 CB PRO D 186 102, .346 16. .799 96. .590 1. .00 42. ,85

ATOM 3933 CG PRO D 186 102. .830 18, .176 96. .915 1. .00 43. .55

ATOM 3934 C PRO D 186 99. .835 17. .148 96. .460 1, .00 41, .51

ATOM 3935 0 PRO D 186 99. .275 18. .221 96. .670 1, .00 40, ,81

ATOM 3936 N THR D 187 99. .337 15. ,984 96, .862 1. .00 41. ,66

ATOM 3937 CA THR D 187 98, .108 15. .901 97. .638 1. .00 40, .35

ATOM 3938 CB THR D 187 97. .232 14. .753 97. .203 1, .00 39. .73

ATOM 3939 OGl THR D 187 98, .044 13. .590 97. .003 1 .00 40, .03

ATOM 3940 CG2 THR D 187 96. .502 15. .108 95. .941 1, .00 40. .19

ATOM 3941 C THR D 187 98. .468 15. .671 99. .092 1, .00 41. .68

ATOM 3942 O THR D 187 99. .486 15, .041 99. .408 1 .00 42, .57

ATOM 3943 N LEU D 188 97. .612 16, .174 99. .973 1, .00 41. .12

ATOM 3944 CA LEU D 188 97. .833 16, .066 101, .401 1 .00 39. .93

ATOM 3945 CB LEU D 188 97. .967 17, .475 101. .992 1 .00 39, .49

ATOM 3946 CG LEU D 188 98. .640 17, .685 103. .352 1, .00 38. .54

ATOM 3947 CDl LEU D 188 97. .695 18. .466 104, .252 1 .00 36, .15

ATOM 3948 CD2 LEU D 188 99. .031 16, .351 103. .972 1 .00 37, .43

ATOM 3949 C LEU D 188 96. .690 15 .317 102, .076 1 .00 39, .41

ATOM 3950 O LEU D 188 95. .525 15, .693 101, .944 1 .00 39, .82

ATOM 3951 N ARG D 189 97. .033 14, .254 102, .795 1 .00 38, .29

ATOM 3952 CA ARG D 189 96, .050 13 .463 103, .515 1 .00 37, .44

ATOM 3953 CB ARG D 189 95. .760 12 .168 102, .751 1 .00 37. .63

ATOM 3954 CG ARG D 189 96. .969 11 .294 102 .500 1 .00 40 .60

ATOM 3955 CD ARG D 189 96, ,551 9 .935 101, .942 1 .00 41 .74

ATOM 3956 NE ARG D 189 97, ,654 8 .970 101, .942 1 .00 42, .49

ATOM 3957 CZ ARG D 189 97, .512 7 .668 101 .714 1 .00 41 .00

ATOM 3958 C ARG D 189 96. .630 13, .156 104, .891 1 .00 36. .92

ATOM 3959 0 ARG D 189 97, .844 13 .071 105 .035 1 .00 37 .76 l S

© o ro c ri r- τ r~ oθ 'tf <τi ri r-- ιι m cN θ vD o cn r~ crι o o ^^, co ro ιn

CΛ o cN cn r ri cn o θ "tf CN 'tf O ri ri r^ oo oo ^' m in oo 'tf CM co σi co in θ ri "tf in cΛ oo cM c ro r oo o "tf m rH cri ri m ι ιn 'tf 'tf r- r- co cM ι> σι CD -tf CM co m r cn cn

H δ r" LO 'tf i in "tf CD r cN CD r-- r^ in i co r~ cn o o o ra cn <o ^ ro iH CN CN c ' U ro ro oo oo r co ro ro ro oo ro co ro co co co ro oO 'tf co oo oo ro oo ro ro co eo cM ro ro co m oo oi oo ro oo ro oo o^

OOOOOOOOO oooooooooooooooo 000000000000000000000000000000

000000000 oooooooooooooooo 000000000000000000000000000000

cn o «tf co cn "tf co co ∞ ro ∞ r-- oo cN 'tf r^ cM cn cn ιθ 'tf iθ ' p- ∞ r~ co r-- rH cn o "tf ω m w ■^ tn ^ m n ^ ^ N ^ w ^ (Nl ιn o H ^ ιη ln N ^ o ιn ιn M N (» H n oo ^ H n ^ o ^^■ (η ι' ffl o o ^n co (^ ι H oo ι cn ιB o u^ co o ω N N α >» ι3\ ^1 H H Io ω H ^ ιη ^ n flo n <ι ω ι!o m ιn m « H co o ι N (I) tD N n w o ιη o H (D ^ (Λ ∞ ^^ ιo ι o n o n ^ ιn '» n <• m r~ oo r- oo t~ oo r~ r-- co oo cn r^ r~ oo oo oo r~ r- iD o ri ri cN ro m in io r— ro cN ro ^r m co i— r-~ c oo ri o cn co o cn o σι σι oo r~ co oo oo co cn

O O O O O O O O O O O O O O O O O O O O rl

"tf m r- 00 m 0 r- c O ri 'tf rH CN i o in co oo fo O rH i' co cD cri D o r ^r co m oo i' H n -c cn r-- c cD CD r o <Ti cn ri cri o r^ r- ^^, cD in o rl 00 r— 00 co T 'tf OO ri σi rl CD CN CM CM m 'r OO OO CM CO 'tf m CM Cn rl co cM co co cD o θ ιn ri cM CM r-- cD CM θ ri o o ιn oo m cθ ri σι ιn ι-H θ o r- r- ri r~ o CM rH CM cn o 'tf eo oo co m 'tf O OO 'tf m oo rH o oo oo oo c co D 'tf ri m ovi m 'tf CM O r^ c cD o o r- o σi o r- oo ro cD rH o c ro cN ro uo in r- in cD r- r- so r-~ o o cn oo oo co r-- σι σι cn < ι σι oo oo o o r~- cD r- co ^Ln co ιo co ιn "tf m ^r* "tf -^etf ^Ln 'tf 'r θ r- m ID CD r- r~ cn 00 rl rl cn oo oo oo r-- r ri cn r~ r- O CM CO T rl ro O ri cN ri O ri CD rl 00 in rl in 0 o oo oo co -q^, >tf oo rl cn CM rl CO 0 r- rl oo W W ι "f (o n «' N N H H H H H

o o o o o o o o o o o o o o H H H H H H H H N N N N N N N N N M i'i n fn tn f t tn inf i' o' in in in in in io nno iD io r- r- cn cn w cn cn oo oo cn cn cn cn cn cn cn cn cn cn cn cΛ cn cn cn cn cn cn cn cn cn c^

Q Q Q Q D Q Q Q Q Q Q Q Q Q Q QQQQQQQQQQQQQQQQQQQQQQQQQDQQQQQQDQQQQQQQ D O D D D D D D CO CO CO CO CO CO CO CO CO Z Z Z Z Z Z Z Z X X X X CO D D D D D Cxl ω

PS OS OS OS OS OS OS OS Cύ OS OS OS dl Cxl Cxl Cxl [χl Cxl Cxl Cxl X X X X X X X X X c co c co co o co co H H π i- x x x x a ni j a a x a EH EH EH EH EH EH EH EH EH EH EH ι-a π H-a Hi a a Hi Hi J t a a a iJ tf tf tf tf tf tf tf tf O CJ CJ CJ πa HI HI πl H! CJ CJ CJ CJ CJ CM CM tf c^Q c α cxi c^xi α cxi co co a tf cQ cj Q Q tf co cj α ω co tf 03 CJ Cl Q to z u υ υ υ o υυ z υ o υ υ o z o υ u υ o υ o z o oo u υ z υ o z υooozooz tfυυ tf CQ tf o z υ o u o z o υ z tf υ o o o H w n >ιt' in Φ co m o μ N ⁽ 'i ιn ω h to σι o ri N (η ^ ι ω ^ cD θ\ θ H (sι n ^ ιn Φ ^ (o oι o H N n <i' in iD r- oo m o H N n ιj

00 ^C' l-⁾ w a Φ ω « « ^ ^ ^ ^ ^ ^ ^ ^ ^ α) ω ω » ro α) ω ro co ω cΛ m cIl n ι3 <J σι <Jl o ci o o o o o o o o o o H H H H H cyl σ^ ⁽Tι o σ Λ cτ^ cJ o o o^ ι^ ⁽Tι o σι σ^ σ\ σ ⁽Tι σ σ <Λ σ ⁽^ (Jl σ c <J c^ cτl σ ⁽yι tτι σ Φ ^ ⁽^ι σι ⁽τ^ a^ o o o o o o o o o o o o o o o oo ro oo oo oo ro ro oo co c oo ro ro ro oo oo oo oo ro oo oo oo ro M co co c oo oo oo oo oo oo m oo ro oo oo m

© o 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2222222222222222 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 O O O O O O O O O O O O O O O O O O O O O OOOOOOOOOOOOOOOO O O O O O O O O O O O O O O O O O H EH EH ttf tf tf tf tf tf tf EH EH EH EH EH EH EH EH tf tf tf tf tf tf tf f tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

ιn cθ rH r~ oo r

^■q> m

1" ']" ooo ooo

^ H N ln N ln co Φ m ιn n n ^ (J> H o w ^ r^ 'f ι ra m <Λ ^ H H lo n ^D O N tn ^^ ^■ vo ι o ■!^ ω Λ oo m (η ^ H (»l ^ (Jl ιn 'ϊ O o m ιn N Ol N (Jl ιn ιn ^ CN n Φ n μ w (lo μ H W ^ N ( O ^ H 9 ιn ιη o o3 m H O O o ^ ιn c^ N W ιn Λ ιn ^ (^,) co ιn H ιn ιn l ^• ι ol m π ^ iJi in o n w M oi ^ m in ^ H ^ H N Oi o H ^ ω co oi ffl i ^ w io i N t ri H iη σi o o o iη in iD ^ o io oi ω iη N v in iJi n ^ σi H H H N n n co (π oo m ^ m o m o σι ^ d N θ H θ σι co θ N π N ( r tvi N H θ o ιn ιci ιn «) i£) ιn ιn r- iB α) is iΛ r- α) iJi OT

O rl iH iH rH iH i-H O O O O O O rH O O rH O O iH iH rl tH iH O O rH i→ rl rH rH rH rl i-H rl i-H iH i→ i-H rH rl iH rl rl iH iH iH rH r^ i-H rl rl iH i-H rl rl rH rH iH iH iH rH rH iH iH i→ iH iH i→ rH i-H rH iH i-H rl rH iH iH rl rH i→ rH rH iH rH rl ιη (Jl ra ■» H ro H ^ H lo ^ ^ m "l' ιn o o H ^ ιo n w ιn O H (Λ N ^ (Λ l 'τ ιn ")• Φ o ω Λ ^ N ^ ιη ι ^ (D (Jl O o H (ι oo ^o o (ι N ι^r) ιθ H H H o ω ω N H Λ H θ (» r- θ3 ^ o ιn <j ^ θ f in ιn o >j ιn 5r ιn co H in ι ι N ^ co ιn Λ H >» iD N ω (η o H i») o θ "f i ^ o ^ ^o ι» | |fl m ri oo cΛ ^^ (^ι rl H m ιη o3 ^ ιn ω m ω o^ ^ ιn n ιo ιn ιB H ^ ^ N H t^| H 'f "f co ^ «τ O H ιn σl H o p ιn H ω ra cΛ ^ (η o H N H m H n o H O H O N H (^ ιη ■J ιn ^ f ^ I l H N ( ^l H H H O o <Λ oo Λ oo r• H o c^ι ι»l ^ ιn u^ ιn ^ oD ^ 'J ιn >a^| ιn ^n •» ^o iH iH i-H rl rl rl rl rl rl rl rl rl rH rl rH i-H H rH rH i-H rH rl rl rl rl rl rH rl rl rH rH rl i-H rl rl rH rH rl rH rH rl rl rl rl rl rH rl rl rl rl

H ■^' ω 3 N <j' t H t^ι o c^ι o H o o e a ^ ^ ^D φ lD ιn ιn ln ιn ^ fO N H ι o ιη n ιn ιn ^ ^ (xι ^o ιD ^ ιo ^o ιn ιn ^ ^ oo Λ m ιIι <J) "f Hf ^ (J N H n cn cn cn cn cn cn cn cn cn ∞ ∞ ∞ ∞ oo ∞ ∞ ∞ ∞ ∞ ∞ co ∞ oo oo oo oo oo oo cD ∞ oo ∞ ∞ oo oo ∞ ro

^ r- ^ ^ ^ ^ ^ ^ ^ » m o os ιIι ⁽Λ oι ι^ι l lJl (Il lIl o o o o o o o o H H H H rl H H H H H N ^ι (^l ( (^l ι ^^ι t N ( l f^,l ( ^^ ι^,) P1 cn cn cn cn cn cn cn cn cn cn cn cn CTi cri cn cn cn cn cn cn cn o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o

H H H H H H H H H H H H H H H H rl H H H H M r N N t ⁽NI (\| N N W N N N (\] N ⁽\I C N (\I C\I N C Cg N N N CV| N N N C\I N N N Q D Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q cxi ω ω cxi c-i c-i cxi cxi c-i co co co co co O O O O O O iii tti ώ Oj ni Oi fti iii ntn røn n ton w wwo u ts o u ou u uo u wwω w iii a a a a a a a a a x x x x x OS OS S OS OS OS CO CO CO CO CO CO CO CO H M H H H H tS Λ βi S os cS ^βj Bi Λ cu Bi Hi a a Hi a CM Cu CM CM C-i C Cu Cu C Ha Ha H Ha H cM αi αj MC C-iC tf tf tf tf tf tf tf tf a a a H H a a a a a a tf tf tf tf tf tf tf tf tf tf tf i M H i i-H rl CM rl CM r| CM CM rl rl CM CM rl

CQ CJ Q Q Cxl Cx] CO Q tf CQ CJ tf CO CJ Q Q tf CQ O Q Q Cx] Cx] tf cQ c α ω eo a a tf O CJ J o o o u υ o o u o z o o o z υ υ o o o z o υ υ o o υo υ o υ z υ z υ o z υ o υ υ z u z z u o z υ υ o υ

o2222 2 2222222222222222222222222222222222222 EHoEHoEHoEH o22 EHoEHoHoEHoEH EoHoEHoHoEH EoHoEHoEHoEHoEHoEHoHoEHoEHoHoHoHoHoHoEHoHoEHoHoHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoEHoEH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

CM r- cn ri 00 'tf "tf in 'q' r cM ri "tf " ' 1^, oooo oooo oo oo <n ri σι ιn o o ιn c-~ oo co co o o cM tn o «tf CM cn m r-- CN ro cD 'r oo en -tf C wD o i_'oi r i-- i Un cMN i HnI r-- T ID in t H in M¹ CO Φ NO m cn cD in cD ro o o o cD ι-H co co ιn cn ιn 'tf θ in cn cM 'tf r~ ro cD ro ιn ri ri co rrii oooo ccnn ccMM oooo rr~~ oooo cn r- co cn o cM ri cM r- ri o o oo cN r- ιn oo "tf o oo rθ ri cn ri rH -ϊr Ln oo cn cM CM Co cD m ro ιn r- 'tf "tf r~ cn ro oo r-~ θ ri co ri eM in ro co r-- ri r--. 'tf r--' ro oo o r- r~ co ιn ι< ro ^ι^, oo r "tf CN ι-H O cn oo cn oo o oo o o cn co cn r- c^β ιn ιn cD -θ ''tf cθ θ cθ '^j« ' o CM O rl rH rl rl l-H l CM rl rl rl rl rl

CM rl rl rl rH rl rl rl rl rl rl i-H rH rl O O O O rl O rH O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O rl rl rl rl rl rl i-H rl rH rl rl rH rH rH rl rl rl rH cn o oo ri cM Co r^ o cn cD '^r oo ' 'tf O m ro rH cn cD oo oo o co r- ro o cN 3 ∞ "tf ro ιn ri cn ro cn cM oo ri cM r-- r- o cM co co cN co r cn ιn oo r ri o co cM CN cn co σι cN in r-- r~ cD r- oo cτι cn r~ "tf oo m r- m ro cD r^ o CD θ "tf rH in o oo rr^- ιιnn coD cvDo rr^-- ciD" o<»o rr^- rr^-- oooo ιιn oroo cvDD ''tftf rroo ooo ccnn ^'qi'' Ccoo oσi LLθθ co ri LO oO rH cn oo r- ro o cM ' r-i ri o r- r^ oo oo o o oo T cn co "tf ro cM cn cD cM Ln o o O r ro co in oo oo oo cN in in cri cn cM CM co in rH CM in r- r~ t— σi oo cn r^ r^ co oo oo cn co r-- "tf r— cD in 'tf σi cn o rH r ri rH ri o cΛ cn oo cM C o 'tf m o o cM C ri ri o cn oo cn oo co oo m co r~ rl rl rH rl rl rH rH rl rl rl rH rl rl rl i-H rH rl rl rl rH rH CM CM CM CN CN CM CM rl rl rl CN CM r CN CN CM CM CM CM CM CM CN CM rl rl rl rl CN CM CM CM CM

LO CM r- co 'tf c cD 'tf oo in oo r- m r- oo rt CD in co r- CM rl 'tf CD

^ π ^ ( ιη "l' v ^ co co co co co ∞ co co

n ιη r^ ^ %f "f v ^n ιn ιn l ιD W ιo ιe ιB ^fl ιβ ^o ^o ω lll ^ ^ ^ ^ tB ω a! t» o oo ω a (7l m (^l Φ o o o o o o o o o o o o H H ri

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O rl rl rl rl rl rl rl rl rl rl rl rl rl rl H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CN CM CN CM CM CM CM CM CM CM CM CM CN CM CM C^

Q Q D Q Q Q Q Q QQ Q Q Q Q Q QQ QQ Q Q QCl Q Q Q Q O QQQ QQQ QQ Q Q Q Q Q Q Q Q Q Q QQa Q Q QQ Q Q m ω ω x x x x x x x x ps ps os ps os ps p c ri ps s tf co co c ω co i-i i-i i- i-a j Ha H cj u o cj oS oS o os tf cS cs ps cS oS QS os tf aπi aHia Hi a aHi a a < >< >H ι X X X X X X X X X X X X tf tf tf tf tf tf ft oS oS oS cS oS X X X X X X X X X X X X Hi

M l rl CJ CJ CJ CJ CJ CJ CJ CJ EH EH EH EH EH E ^"H EH H H EH EH H Ha r ι-a ι-a Ha > > > > > > > tf tf tf tf tf EH EH EH EH EH EH M^~ EH EH EH EH EH rl rl CM CM rl CM rl rl CM CM

Q υ υ o z υ f tf cQ cj α cxi α ω coa tf CQ tf CQ C5 o tf CQ co CJ o z tυ υ o z tf cα cjα cxi α ω co a tf υ υ u o υ u υ u o u o υ o υ o z u υ υ u υ o z υ o υ z u uuuu u uu o o o z υ u

O ri N ^^ 'ιf ln w ^ ra (ΛO H N n ^ ^n ^£> ^ oo w o H csι n ^ ιn ^D ^ ιI) σl O H (^ι n ^ ln ^D ^ o m o H ι m "l^| ln w ^ ω <! O H t^ι (^,) ^ ^ ^ ^ ^ r^■ ^ ^ ^ oo m co o!) (D α! co co co co Ol OHIl ⁽J\ (Λ (Jl (^ oι ol l o o o o o o o o o o H H H H H H H H H H C t^ι t^^ ι e

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O rl rH rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rH

^* ^* ^* ^3* ^* ^* ^* ^* ^* ^* ^* ^3* ^* ^* ^ϊ* ^* ^* ^3* ^* ^* ^ϊ* ^J* ^* ^J* ^^ ^* ^* *3* ^ * ^J* ^^ ^P ^* * * * ^* ^* ^* ^* ^* ^3* ^J* ^* ^}* ^T *_*r *sj* j* ^* ^* "S3* ^* ^* *5f ^3* oo l-H

22 22 2 rH 22 2 22

O O O O O o O O O O rH H © tf tf tf tf tf tf << tf tf tf tf tf tf o

Tf

Tf r- "tf θ r^ o r^ oo ιH "tf oo o co o ι θ r Ln cD in ιn rH "tf CN CTi o o σι c» C in r~ 'tf r ιθ ri oo oo c CM i cD o r~ o o ιn o o r- r~ m ri rH "tf f> H n ri ln oo (o ^o o c ln ^o ιo ^ ^O H σl H O ^o co n ^ f O "f lfl oo o oo co o ^ W l ιn ( v <D ι^,^ (^l ^ ^ CN 'tf O c cN m c o 'tf O cn JS §

© CM CM co (^ "tf ^ r~ CN ιH ιH rH Ci "tf '^ ι 'tf in cD ιn co ιj3 o o oo oo oo r-- r^ oo ι '^ ''r θ ιH 'tf 'iⁱ c cN CM c^ © 'tf ^ "tf "tf '^ ^ 'tf '^ 'tf 'tf 'tf <tf "tf "tf "tf "tf 'tf 'tf ^,^ 'tf 'tf ^ ^ ro ro oo oo oo oo ro oo co oo oo oo ro oo oo oo ro oo ro oo o^

CΛ ooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooo υ rH rH rH iH rH i→ rl rH iH iH iH iH rH iH rH iH rH rl iH iH iH iH rH rH iH rl rl H iH H rH i-H iH iH rH rl rH iH iH iH ln π ιD n cΛ ^ H "^ H ^ <Jl o O ln ω m ffl H ι^) N H fn ln co N H o tD n lJl H o o5 tD ω (X) (D CD l ^ α3 ^D σ H H co l ^l H f 03 "tf O CD H ιn w co ( ^ O (J ^n ro ^ ω ^ (η σl w m (η o m ^ ^n w o H » ^ ω ra ln ω N <^ « co o ^ (lO N H ∞ * cι H Φ N .. O_ o_ ^. ω _ N .. (.^,^. o in co ^ H ^n co m l o (^ι co N ^ H ^ ^ fl <l^ι N m c^l H O Ol ιn ln (^ι ιcι o ι ^ 'l' O H O ιil ln ι^,^ O ln co ln ^ co n ^o o cn coo 9-tf ιrηo oo eooo cn cD ri rH

CM CN rθ "tf in ιn r~ i' in 'tf i' "tf CM ri θ ri CM θ cn o oo m vo io r- oo oo oo r— oo cn o rl O O rl CM rl CM CM OO rl ri n rO ■tf in co m co ιn co r- r~ o o o o o o o o o o o o o o o o o o cn o cn o o o o o o o o o o ri rl rl rl rl rl rl rl rl rl

H l O H n {D co cD ι m co r~ cD ^i' "tf r cN i cN rH CN θ r ri o O rl rl CN rl 00 "tf rH rl O O OO OO OO CD O O rl rl CO CO OO m rl O O O σi lXl CO CD rl rH rl CM

CM CM CN CM CM CM CM CM CM CN CN CN CN CN CN CM CM CM CM rl CM CM CM CM CM CN CM CM CM CM CM rH rl rl rl CM CM CM CM CM CM CN CM CM CM CM CN rl rl rl rl CM CM CM CM

!→ ιH CM CN CM CN CN CM CN ro ro oo ro n oo oo oo ro oo ro oo ro oθ '* "tf ^ ^ ^ 'tf in ιn ιn ιn ιn ιn ι^ rl rl ι-H rl rl rl ιH ιH ιH ιH ι-H ιH ι-H rH ιH rH ιH ιH ι-H ιH ι-H ιH ιH ι-H ι-H rH ι-H ιH rH ιH ιH rl ιH rH ιH ιH r^ CN CN CM CM CM CM CM CM CN CM CN CN CM CN CN CN CN CM CN CM CN CM CM CN CN CN CM CN CN CM CN CN CN CN CN CN CN CN CM CN CN CN

QQQQDQQQQQQQQQQQQQQQQQQaDaQQQQQQQQaQQQQaQQQQQQQQDQQQQQQ tf tf Ct Ctl C-i CLS C-Ϊ C-I -i C C Cii C CM μ C CM C Oj C^

Ha H a a a a ^χ, os -. -; ctι C; c-; -; pS S o o c-. td C^χ] ω c^χi ω c^χi ι- ι-a Ha tf tf E^{H H} H E^H En E^H E^H H E^H H E^H E^H H ^H E^H H E^H E^H E^H H E^H CO CO O CO C CO H H I H Hl M ^Hi rH rl 2 2 2 2 2 2 tf tf rl CM CN CN OO i-l rH CN OO CN CM rl rl CM rH rl ooz tfυPυQ CoJ CυJυoz tfυCoO Ou^QυCυxl Coxl QoCz-l cuOυco aυυoz tfυoCQ CoJoozo tf CuO CuJ CoJ Qυooz tfo CuO CoJ CoJ Qoooz tfoCoQ CuJcQoCoxlυozo tf ιn cD r~ oo c o ri cN ro -^ ιn co r^ oo oo θ ri cM rθ 'tf i co r^ oo c θ ιH CM θ 'tf i cD r--- co c o ι-H CN ro ^ ι^ cM CM CM CM CM ro ro r r ro ro oo co c "tf 'T 'tf "tf "tf "tf 'tf 'tf -^ 'tf in in in i Ln i i i in in co co iD ^ io ^

H H H H H H H H H H H H H H ri H H H H ri H ri ri ri ri H H ri H H ri rl H H H H H ri ri H H H H H H H H H H H H H H H H ^ * ^T ^* *^* ^ * ^J^ ^3* ^* ^* ^ϊ' ^J* ^ * ^ * ^3 ^3* ^ * ^3* ^3* ^3* ^ * ^3* ^* ^i|3^ ^^ ^3^ ^ * ^^ ^* ** ^3^ ^ ^ ^3* ^3^ ^J^ ^3* ^3^ ^3* ^* ^3* *^* ^^ *^^ ^3* ^3* ^J' ^■ζj' ^ * ^4' ^p ^jι ^ζj ^* ^ * ^J* ^1^ oo rH s reH 2222222222222222222222222222222222222222222222222222222 rH 0000000000000000000000000000000000000000000000000000000 O tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

Table!

ATOM 4180 CB ASP D 218 88. .201 22. 968 117. 642 1. 00 35. 60

ATOM 4181 CG ASP D 218 87. .680 24. .115 118. ,468 1. 00 38. 16

ATOM 4182 OD1 ASP D 218 87. .193 23. ,858. 119. 592 1. 00 40. 42

ATOM 4183 OD2 ASP D 218 87. .753 25. ,272 117. ,989 1. ,00 37. 02

ATOM 4184 C ASP D 218 89, .268 21. ,533 119. ,460 1. 00 35. 32

ATOM 4185 O ASP D 218 89. .088 20. ,318 119. ,380 1. 00 37. 02

ATOM 4186 N SER D 219 89, .294 22. .181 120. ,623 1. ,00 35. ,62

ATOM 4187 CA SER D 219 89, .073 21. .525 121. ,916 1. .00 36. 41

ATOM 4188 CB SER D 219 87, .616 21. ,757 122. ,361 1. ,00 37. ,09

ATOM 4189 OG SER D 219 87. .424 21. ,434 123. ,736 1. ,00 40. 88

ATOM 4190 C SER D 219 89. .422 20. ,024 121. .962 1. ,00 35. ,85

ATOM 4191 0 SER D 219 88, .535 19. .165 122. .012 1. .00 35. .43

ATOM 4192 N VAL D 220 90, .721 19. .729 121. .951 1. .00 35. .38

ATOM 4193 CA VAL D 220 91. .217 18. .356 121. .999 1. .00 34. .96

ATOM 4194 CB VAL D 220 92, .725 18. ,305 121. ,745 1. .00 34. ,89

ATOM 4195 CGI VAL D 220 93. .016 18, ,848 120. ,369 1. .00 35. ,35

ATOM 4196 CG2 VAL D 220 93. .471 19, ,095 122, ,824 1. ,00 34. .72

ATOM 4197 C VAL D 220 90, .940 17. ,663 123. .329 1. ,00 34. .86

ATOM 4198 O VAL D 220 91. .165 18. ,204 124. ,403 1. .00 35. ,98

ATOM 4199 N VAL D 221 90. .470 16. ,437 123. ,227 1. ,00 34. ,78

ATOM 4200 CA VAL D 221 90. .117 15, .631 124, .373 1. .00 34. ,91

ATOM 4201 CB VAL D 221 88, .632 15, .251 124. .235 1, .00 34. .42

ATOM 4202 CGI VAL D 221 87, ,779 16, .515 124. .192 1, .00 30. .48

ATOM 4203 CG2 VAL D 221 88. ,423 14. .475 122. .935 1, .00 30. ,80

ATOM 4204 C VAL D .221 91. ,000 14. .374 124. .353 1, .00 35, .97

ATOM 4205 O VAL D 221 91. .607 14, .056 123. .332 1. .00 37. .52

ATOM 4206 N PRO D 222 91, .068 13, .637 125. .469 1, .00 35. .56

ATOM 4207 CD PRO D 222 90, ,372 13. .891 126, .742 1. .00 35. .68

ATOM 4208 CA PRO D 222 91, ,883 12. .419 125. .555 1. .00 34. .78

ATOM 4209 CB PRO D 222 91. .426 11. .801 126. .874 1. .00 36. .22

ATOM 4210 CG PRO D 222 91, .150 13. .011 127. .712 1, .00 36. .43

ATOM 4211 C PRO D 222 91, .714 11. .458 124. .383 1, .00 33. .09

ATOM 4212 O PRO D 222 92. .682 10. .842 123. .935 1, .00 33. .47

ATOM 4213 N SER D 223 90. ,490 11. .325 123, .887 1, .00 31. .05

ATOM 4214 CA SER D 223 90, .250 10. .412 122. .783 1, .00 31. .65

ATOM 4215 CB SER D 223 88. .761 10. .353 122, .460 1 .00 29. .34

ATOM 4216 OG SER D 223 88. .308 11. .570 121, .913 1, .00 32. .73

ATOM 4217 C SER D 223 91. .041 10. .824 121, .545 1, .00 32. .52

ATOM 4218 0 SER D 223 91. ,237 10. .033 120, .627 1, .00 33. .05

ATOM 4219 N ASP D 224 91. .501 12, .068 121 .524 1 .00 33. .64

ATOM 4220 CA ASP D 224 92, .276 12. .556 120, .394 1 .00 33. .83

ATOM 4221 CB ASP D 224 92, ,216 14, .088 120, .303 1 .00 33. .17

ATOM 4222 CG ASP D 224 90, .866 14, .593 119, .820 1, .00 33. .79

ATOM 4223 OD1 ASP D 224 90, ,395 14. .105 118, .769 1, .00 35. .24

ATOM 4224 OD2 ASP D 224 90, .278 15. .478 120 .482 1 .00 32, .14

ATOM 4225 C ASP D 224 93. .723 12, .116 120 .515 1 .00 34, .68

ATOM 4226 O ASP D 224 94, .450 12, .112 11 .531 1 .00 35, .14

ATOM 4227 N LYS D 225 94, .146 11, .753 121, .722 1 .00 35, .77

ATOM ^'4228 CA LYS D 225 95. ,527 11. .323 121, .923 1 .00 36, .05

ATOM 4229 CB LYS D 225 95. .731 10, .715 123 .315 1 .00 3 .64

ATOM 4230 CG LYS D 225 95. .658 11, .662 124 .489 1 .00 40, .94

ATOM 4231 CD LYS D 225 96. .158 10, .947 125 .731 1 .00 42, .47

ATOM 4232 CE LYS D 225 95. ,590 11. .577 126, .984 1 .00 46, .13

ATOM 4233 NZ LYS D 225 96. .280 11, .098 128 .215 1 .00 48 .29

ATOM 4234 C LYS D 225 95. .907 10. .274 120 .890 1 .00 34 .81 on CO 00 O CM σi ri ro ri cn "tf en

OO O O O O OO O O OOO O OOO O lO _rH OO CM iH rO ro rO _OO i→ _OO _CO rH rH σO CN _CO OO C_O O Cn eO CO O rH ι cN θ o σ^ co ^ r-- rH oo oo σi "tf cθ 'q< 'j' r~ r-- ιn ri cM ri 'q^, CM cn ^r oo ιn c3^ 'tf ro o o m co o cyι eM CM ι-H ri ro m rH co oo σι ιn 'tf m cN r-- oo ιn ri r~ e o [~ cM in θ ιH H ι r- CN oθ "tf r~ ι-H ro c~ r^ o cN r-- r r~ r-~ C r^ r~ r-- r--- co ro ro co ιn ro <N σ> o m 'tf θ ιn ιn cN in ι^, oD r-~ o cn cN rH CN Lθ o σi co r~ U3 r~ co cM θ co cn o ri r-- ιn r rH in rθ "tf cn cn oo o oo oo co r-- ιn "tf o o oo oo oo r- CD in r- r- - in i' ^ r r ^i' m cO 'tf 'tf CD r-- C CM cn cn o oo co oo co r- m in r- r- 'tf OO ro cM 'tf 'tf CN n ri O ri cn CM oo oo co r-

CM CM rl rl rH rl rl rl O O rl O O O O O O O O O O O O O O O O O O O O cn o oo oo cn cn

CN C cn co r- ■- . rl ιH rH cN cn -o ro ro cD o oo oo o coθ rii CN Cn θ r- r -cr 'tf O O CM co "tf O r- o r~ co σi O Cn O iH Cn cn cO CD i-H -tf CM CO rl O LO OO O ( (M M ^ Ol ^• ιη m H o ri ιn ι f^r) "» l ^n m N ^ O (X! co o σl fn ^fl ^ ^ r^ ιo ^o (^ ∞ α) (5l ^ ^ H lD H ^- ^ ^ o m 00 CN CD CM 'tf l r~ -^¹ M θ CN Cn ιo r~ ro o ιn rH θ ιn rH Co r-- o rH oo cn o ιn ιn 'r cN ι-H oo cN CN ιH r^ oo ιn cM Cθ o ιn ^ σ ro σ> r-- cn «tf o o ri o m in ri co co co cD «tf CD rl ι-H ιn CTι r CM ^ -tf Cn oθ rH O O ι-H αD r~ rH CD rθ CM ιH O CD CM 'f O OO ιn θ CN OO CM r~ Cn oθ O H O O CD CO r-- 00 m r- r~- oo cn co cΛ θ ri CM ri cn oo oo oo oo r-~ r- co ιn 'tf in "tf θ rH θo O rl rl CM O Cn rH O rl CN rl CN O rl O O O oo o Cn cM CN OO OO CN CN OO rl CM cn cn cn cn cn cn cn o o o o cn cn cn cn cn cn cn cn cn cn cn cn o o cn O O O O O OO O O O O O O O O O O O cn o cnooooo ooo o

ιn ω ιo lfi ^ ^ ^ ^ ^ ^ ^ ^ (o co ffl oo co a oo ω ι» tD co c al ^^ι ⁽Λ σι Ol Λ Ol o o o o o o H H H H rl H H H N l N N ^ι ( ^^ fO P^

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM rO CO rO OO rO rO CO CO rO CO M ( CM CN CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM

QQ QQ QQQQQ Q Q QQα O Q QQQ QQ Q Q Q Q D QQ Q Q Q QQQ QQ Q Q Q Q Q Q Q D QQ Q QD Q D QQ Q Q

X X X X Z ≥ Z Z Z Z Z Z OS PS OS PS PS OS OS os os cr- co co co co co co xi xi i ω ci txi cxi Ci Ha Ha Ha μi r H i-a co c co o co c co x x x x a a a a a x x x x x x H H H i- Ha H Ha i-a tf tf tf

CJ CJ CJ CJ tf tf tf tf tf tf tf tf EH EH H EH EH EH EH EH EH H U O U O O U H H H H H HI H > > > CJ CJ rl CM rl rl CM CM rl CM CM rl rl rl CM tf tf cQ cj α α tf cQ cj Q ti Q ci to a tf cα o o tf CQ C tf CO CJ CJ Q tf PQ CJ tf z oo O z o υυ o z υ o z o υ υ υ υ υo υ o υ o z υ υ o o υ o z o υ o o co z o o υ υ o o zυ υ o υ o o z υ in co r- oo oo o ri cM ro lJ' ιn ω ^ o m o ri N ^ "» ιn ω ^ ω σl O H N ( "f ln \D ω m o H N (η "f ln w (π m o H (^ι ιη ^ ln ω ^• (D m "» ^ ^ ^ ^ ^ ln ιn ιn ln ιn ιn ιn ln ιn ln ω ^D Φ lD lD ω ω ιf⁾ lo Φ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ω co ∞ ω o5 ∞ oo cI) ( ι ω

CN CM CN CM CM CN CN CN CN C CNM CCMM CCMM CCMN CCNM CM CM CN CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CN CM CM CM CN CM C^

^3* ^3* ^ * ^T ^3* ^3* ^ ^^ ^3* ^** ^* ^3* ^3* "^* ^J*

00 rH ©

2222222222222222222222222222222222222222222222222222222

© ooooooooooooooooooooooooooooooooooooooooooooooooooooooo o EH EH EH H EH EH EH EH EH EH EH EH EH H EH EH H H EH EH EH EH EH H EH EH EH EH EH EH EH H EH EH EH EH EH EH H H H EH H H EH EH EH EH H EH EH H EH EH H tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

Table 1

ATOM 4290 CB GLU D 233 101, .752 11. .482 97. .710 1. .00 46. 98

ATOM 4291 CG GLU D 233 101, .754 10. .584 96. .507 1. .00 54. .51

ATOM 4292 CD GLU D 233 101, .552 9. .132 96. .892 1. .00 59. .37

ATOM 4293 OE1 GLU D 233 100, .659 8. .864 97. .739 1. .00 61. .58

ATOM 4294 OE2 GLU D 233 102, .288 8. .267 96. .348 1. .00 59, .83

ATOM 4295 C GLU D 233 101. .941 13. .363 96. .090 1. .00 45. .68

ATOM 4296 O GLU D 233 100. .961 14. .096 95. .926 1. .00 45. .02

ATOM 4297 N ASN D 234 102. ,747 12. .958 95. .105 1. .00 45. .84

ATOM 4298 CA ASN D 234 102. .516 13. .281 93, .701 1, .00 45. .22

ATOM 4299 CB ASN D 234 103. ,183 14, .614 93, .314 1. .00 45. .24

ATOM 4300 CG ASN D 234 104. ,641 14, .468 92, .946 1. .00 44. .43

ATOM 4301 OD1 ASN D 234 105. ,256 13. .422 93, .165 1. .00 44. .59

ATOM 4302 ND2 ASN D 234 105. ,210 15, ,534 92, ,385 1. .00 40. .85

ATOM 4303 C ASN D 234 103, ,060 12. .112 92, .888 1, .00 45. .49

ATOM 4304 O ASN D 234 103, ,561 11. .149 93, .464 1, .00 45. .48

ATOM 4305 N GLU D 235 102. .965 12. .194 91, .564 1, .00 46. .96

ATOM 4306 CA GLU D 235 103. .410 11. .110 90, .687 1. .00 47. .27

ATOM 4307 CB GLU D 235 103, .165 11. .494 89, .218 1, .00 46. .16

ATOM 4308 C GLU D 235 104. .857 10. .643 90. .851 1. .00 47. .83

ATOM 4309 O GLU D 235 105. .171 9. ,496 90. .533 1. .00 48. .35

ATOM 4310 N TYR D 236 105. .735 11. .498 91. .368 1. ,00 48, .23

ATOM 4311 CA TYR D 236 107. ,139 11, .110 91. .492 1. .00 48, .07

ATOM 4312 CB TYR D 236 108. .000 12. .221 90. .905 1. .00 51. ,78

ATOM 4313 CG TYR D 236 107. ,449 12, .674 89. .579 1. .00 56. .38

ATOM 4314 CDl TYR D 236 106. .553 13. .744 89. .501 1, .00 58. ,00

ATOM 4315 CE1 TYR D 236 105. ,976 14. .112 88, .286 1. .00 60. .31

ATOM 4316 CD2 TYR D 236 107. .757 11, .981 88, .408 1. .00 57, .90

ATOM 4317 CE2 TYR D 236 107. ,184 12. .337 87. .190 1. .00 60. .14

ATOM 4318 CZ TYR D 236 106. ,298 13. .401 87. .135 1. .00 61. .38

ATOM 4319 OH TYR D 236 105. ,748 13, .758 85. .925 1. .00 62. ,75

ATOM 4320 C TYR D 236 107. .638 10. .728 92, .876 1. .00 45. .71

ATOM 4321 O TYR D 236 108. .803 10. .372 93, .049 1. .00 45. .60

ATOM 4322 N GLY D 237 106. .758 10. ,783 93, .863 1. .00 43. .72

ATOM 4323 CA GLY D 237 107. ,177 10, ,429 95, .202 1. .00 42. .52

ATOM 4324 C GLY D 237 106. ,233 10. ,922 96, .275 1, .00 42. .32

ATOM 4325 O GLY D 237 105. .280 11. ,661 95, ,996 1. .00 42. .37

ATOM 4326 N SER D 238 106, ,493 10. ,497 97. .509 1. .00 40. .93

ATOM 4327 CA SER D 238 105. .678 10. ,895 98. .643 1. .00 38. .31

ATOM 4328 CB SER D 238 104. .607 9. ,848 98. .912 1. .00 37. .78

ATOM 4329 OG SER D 238 105. ,218 8. ,650 99. .344 1. .00 39. .41

ATOM 4330 C SER D 238 106. .559 11. ,027 99. ,871 1, .00 37. ,41

ATOM 4331 O SER D 238 107. .577 10. ,350 99. .993 1, .00 36. .75

ATOM 4332 N ILE D 239 106. .166 11. ,919 100. .772 1. .00 37, .40

ATOM 4333 CA ILE D 239 106, .885 12. .138 102. .028 1, .00 37. .41

ATOM 4334 CB ILE D 239 107, .571 13, ,516 102, .117 1, .00 37. .31

ATOM 4335 CG2 ILE D 239 109, .017 13. .429 101, .703 1, .00 36. .88

ATOM 4336 CGI ILE D 239 106. .777 14. .527 101, .305 1 .00 38. .29

ATOM 4337 CDl ILE D 239 107. .409 15. ,895 101, .252 1 .00 42. .39

ATOM 4338 C ILE D 239 105. .828 12. .151 103, .098 1, .00 38. .18

ATOM 4339 O ILE D 239 104, ,672 12. .502 102, .825 1, .00 38. .68

ATOM 4340 N ASN D 240 106. .220 11. ,777 104, .311 1, .00 38. .07

ATOM 4341 CA ASN D 240 105. ,292 11, .775 105, .434 1, .00 39. .19

ATOM 4342 CB ASN D 240 104. .696 10. ,375 105. .660 1, .00 41. .17

ATOM 4343 CG ASN D 240 105. .743 9. ,348 106. .072 1. .00 43, .52

ATOM 4344 OD1 ASN D 240 106. .601 9, ,622 106. .912 1, .00 47. .31 σi ri oo oo O O O O O

^ ι^ co ιH in oθ 'tf r-- o rθ ri cD 'tf i ro c VD cn cM Ln r-- r~ ro o o cD cM CD CN rH ri r~ oo ri m oo ιn oo ι^ r-- r-- cn -rr oo oo ro cM CN CM ro cn ro θ "tf 'tf cn cn r^ co ^ cD O in oo ro co <Ti oo cM r-- ri oo in cM CO "tf CD cn cn cD O Ln o ao "tf io r-. oo cD cn cn o ^,f co θ "tf cn o ri m cn cN "tf ro co ro cD 'tf ri cD 'tf in [^ cD σo oo ri oo cD r~ oo oo r^ ri ri ι cM θ "tf r-- o cM θ rH σi H in r-. 'tf CD oo o m co ^' ri cM CTi co m σi co m oo co σi σi oo cn oo cM cn cN O 'tf in co co r- oo oo o o o oo cn rl CM CM rl 00 r0 00 "tf - ιn "tf CM CN ^^, CO CN rl lo io r- oo oo o ri o cN cn cn oo o cn o o e rH rH CM "tf "tf co r- o o o o o O O rl rl rl O O rl rl rl CN CN rH CM CN CN CM CM CM CM CM rl H H rl H rl rl rl rl rl rl rl rl rl rl r cD o co ιn ri co ι ι oo oo ιn r~ o r~ r~ o D o cM D "tf r ^ ιn cD r-- cM in cM r~ θ ri ιn "tf in ro ιn <τι σ^ o oo m r- co cN cn in r-- r- _'tf co ri oo "tf in 'tf -^ co cM CM D in co σo rH r^ cD cN ro in cM CD αD O CD O r_^ cD ri ri rO 'tf r^ ^ 'tf O cn 'tf 'tf r oo r^ i 'tf rl C0 O 00 O r^ 00 "tf r0 Cn cM CD CD "tf ιH CM CM VO ι-H lO ιH CN in CM rθ OO ιH r O ιn oθ ιH CO CM CM θ n θO r^ VD Cn cθ rH O CM ^ "tf r-- O OO CN CN CO [^ r-- "tf CN CD "tf θo r- cD "tf "tf crι oo o cn θ oo c C < ι rθ "tf i cD 'tf in vo cM c cM CM θ cn o cM ro o -^ ιn cD io r~ co r~ oo σι oo cN ro cM CM θ o o σι o ^ co -^ '^ ι c^ ιn Λ Φ ω H <Jl I» ιn co c c ιH cD (7» cM CM ιn ιn r^ ιn o o o o o o o cn iH iH iH rl rl rl rl

^Q Q Q ^Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q QQQ Q DQ QQ Q Q Q Q Q Q QQ Q QQ QQ Q QQ QQ Q Qa QQ Q Q QQ

Z Z Z to co co co co co co co co tf ciS pS pS PS aPS cd oS oS oS PS oS ps pS ciS pS øS P PS Z Z Z Z Z Z Z Z Z D D D D D D D D CM CM CU C-I CM CU CO CO CO M X X X X X X X i t] ω ci i cχi co co co co c co tf tf tf^' a a a HI rl rl rl M a χ χ H ι-a Ha H Ha Ha ι-a ι- H i i c DC DC 3-ϊ ι-C 3C ^* E-* a EH aEH EH aEH xEH EH EH H EH EH EH EH EH H Cj cj c j j c c cj i- Ha Ha Ha i- H Ha Ha tf tf tf tf tf tf rl CN

Q tf cQ c α α ω cxi tf PQ CJ O tf CO CJ Q txl D txl c a tf CQ O Q C-l Cxl tf Q CJ Q Q tf CO CJ Q Q zoozυouozozooz oυooυozoυυuυoυooυozouυυozo o zυυυυυυo z o o υ o o ιn ω ^ ω ffl O H ( lη v ln ω ^ o (!l O H t^ι (η ^ ln w ^ ω (Λ O H N n ^ ln w ^ lIι l O H ^ι n <^ ι w ^ t_ Jι o H N (») H^ ln ^o ^ oo cΛ ^ ^■^ 'tf «tf ^ ιn ι ιn ι ιn ι ι ιn ιn ιn cD D ^ cD io o iD co o cD r~ (~ r~ ι^ r~ r~ r~ r~ r^ r-- oo oo ro m oo oo oo co oo ro ro oo ro ro oo oo oo ro oo oo ro ro oo oo ro ro oo oo co oo ro oo oo co co oo ro co co ro co co co i^ ro co ^ '^ '^jι ^ ^ 'r ^ ^ ^ ^ ^ 'r "tf ^ ^ 'tf "tf ^ ^ 'tf ^ ^ "tf ^ ^ 'tf "tf ^ 'tf ^ '^ 'tf ^ ^ 'tf 'tf ^ "tf 'tf 'tf 'tf 'tf 'iⁱ "tf 'tf "tf 'r ^ 'tf 'tf ^ ^ "tf 'tf 'r 2o 222 EH oHoEHoEH tf tf tf tf

Table 1

ATOM 4400 C ASP D 246 98. .369 15. ,077 124. 915 1, .00 33. ,21

ATOM 4401 O ASP D 246 98, .793 16. .233 124. ,987 1. .00 33. .23

ATOM 4402 N VAL D 247 97. .181 14, .702 125. 388 1. .00 34. .04

ATOM 4403 CA VAL D 247 96. .259 15. .634 126. ,053 1. .00 34. ,00

ATOM 4404 CB VAL D 247 94, .819 15. .478 125. ,507 1, .00 33, .34

ATOM 4405 CGI VAL D 247 93, .957 16. .651 125. ,942 1. .00 31, .80

ATOM 4406 CG2 VAL D 247 94. .849 15, ,355 123. .997 1, .00 35. ,20

ATOM 4407 C VAL D 247 96, .204 15, .358 127, .557 1, .00 34. .12

ATOM 4408 O VAL D 247 95. ,933 14. .228 127. .970 1. ,00 32. .75

ATOM 4409 N VAL D 248 96. .438 16, ,394 128. ,365 1. .00 33. .95

ATOM 4410 CA VAL D 248 96. .414 16. .264 129. .822 1, ,00 34. .42

ATOM 4411 CB VAL D 248 97, .650 16. .919 130. ,475 1. .00 33. .86

ATOM 4412 CGI VAL D 248 97, .646 16. ,649 131. ,954 1, .00 33. ,01

ATOM 4413 CG2 VAL D 248 98, .925 16. .407 129. ,844 1. .00 35. .22

ATOM 4414 C VAL D 248 95. .202 16. .965 130. ,415 1, .00 35. .72

ATOM 4415 O VAL D 248 94, .969 18. ,134 130. ,116 1, .00 35, ,44

ATOM 4416 N GLU D 249 94. .438 16. .255 131. .246 1, .00 36. ,91

ATOM 4417 CA GLU D 249 93. .272 16. ,836 131. ,917 1, .00 38. ,36

ATOM 4418 CB GLU D 249 92, .182 15, .787 132. ,122 1, .00 41. .10

ATOM 4419 CG GLU D 249 91. .599 15, .230 130. ,847 1. .00 46. .18

ATOM 4420 CD GLU D 249 90. ,669 14. ,058 131. .103 1. .00 48. .79

ATOM 4421 OE1 GLU D 249 91, ,133 13. .032 131. .662 1, .00 50. .76

ATOM 4422 OE2 GLU D 249 89, ,476 14. .166 130. .743 1. .00 49. .83

ATOM 4423 C GLU D 249 93, ,773 17. .262 133. .289 1. .00 37. .17

ATOM 4424 O GLU D 249 94. .255 16. .417 134, .030 1. .00 37, .43

ATOM 4425 N ARG D 250 93. .675 18. .544 133. .648 1. .00 36. .72

ATOM 4426 CA ARG D 250 94. ,156 18. .956 134. .986 1. .00 35. .30

ATOM 4427 CB ARG D 250 94. .622 20. .427 135, .022 1. .00 32, .09

ATOM 4428 CG ARG D 250 95. .801 20. .729 134. .091 1, .00 31, ,09

ATOM 4429 CD ARG D 250 96. .960 19. .717 134. .237 1. .00 27, ,53

ATOM 4430 NE ARG D 250 97. .736 19, ,907 135. .466 1, .00 27, .19

ATOM 4431 CZ ARG D 250 98. .601 20, .901 135. .671 1. .00 23, .34

ATOM 4432 NH1 ARG D 250 98. .819 21, .807 134. .733 1. .00 24, ,08

ATOM 4433 NH2 ARG D 250 99. .236 21. .005 136, .824 1, .00 20. .42

ATOM 4434 C ARG D 250 93. .146 18. .699 136, .123 1. .00 35. .26

ATOM 4435 O ARG D 250 92, .000 18. .335 135. .877 1, .00 36, ,33

ATOM 4436 N SER D 251 93. .642 18. .752 137. .373 1. .00 36. .16

ATOM 4437 CA SER D 251 92. .839 18. .539 138. .596 1. .00 35. .07

ATOM 4438 CB SER D 251 93. .267 17, .254 139. .308 1, .00 33, .85

ATOM 4439 OG SER D 251 93. .280 16. .152 138. .433 1, .00 33. .32

ATOM 4440 C SER D 251 93. .050 19. .708 139. ,564 1. .00 35. .84

ATOM 4441 0 SER D 251 93. .706 19. .560 140. .601 1, .00 36. ,47

ATOM 4442 N PRO D 252 92. .505 20. .888 139. .235 1. .00 36. ,42

ATOM 4443 CD PRO D 252 91. .828 21. .237 137. ,975 1, .00 37. .05

ATOM 4444 CA PRO D 252 92. .655 22. .070 140. .088 1. .00 36, .24

ATOM 4445 CB PRO D 252 92. ,319 23. .219 139. .147 1, .00 34. .89

ATOM 4446 CG PRO D 252 91. ,286 22. .625 138. ,277 1. .00 37, ,22

ATOM 4447 C PRO D 252 91, .790 22. .066 141. ,334 1. .00 36, .91

ATOM 4448 O PRO D 252 90. ,850 22. .854 141. .469 1. .00 36, ,54

ATOM 4449 N HIS D 253 92. .122 21. .166 142. ,247 1. .00 37, .49

ATOM 4450 CA HIS D 253 91. .406 21. .063 143. .501 1, .00 39. .08

ATOM 4451 CB HIS D 253 90. ,229 20. .073 143. .366 1, .00 42. .98

ATOM 4452 CG HIS D 253 90, .599 18. .724 142. .823 1, .00 46, .99

ATOM 4453 CD2 HIS D 253 90. ,222 18. .090 141. .686 1, .00 48. .65

ATOM 4454 ND1 HIS D 253 91. ,398 17. ,830 143. ,511 1, .00 50. ,87 ιo o o "l^, O 00 ro CM O O O O oo CM oo co r- o o «tf r^ r- r~ CN ^ m o co m cD cD "tf τ co ri "tf r cM ri θ ri ri in oo cn ri cΩ oo oo en cD cM CM co ri O ri cM o ro in ro o cn cn cn

CM rl O _ C .N. L-O. o ri cM p- rO 'tf cn 'tf CPi o cD cN CO Ln 'tf H r oo -CT oo cN r- oo h Hf O OJ MH O O H Ol r- oo r~ θ ι— ι θ Lθ "tf r- co o ^ι^, ^' r- o 00 r~ cD co oo o cM r- oo ιo cM cn o o ro oo m cn cn r- co o cn cM θ oo cθ t'— αi -sjⁱ i io c in c cN r- cD LO r— "tf in o cM co in ro cn io m oi oo rl "tf "tf in r- oo oo oo o o oo i r- co i— oo r- co oo co cn r— oo r-- r~ co m oo oo o o cM CM ro cM O O O O O ri cM rH CM CM co cM 'tf in uo cD in m "tf

^^I 'tf ^ⁱ 'tf in LO 'tf LO "tf "tf i' ^r "tf i< 'j' m ιn ιn ιn m m m m Ln ιn ιn m ιn Ln m ιn m ιn ιn ιn ιn ιn ιn m ιn

H H H H H H H H H ri H H H H H rl H ri H H H H H H ri H ri H H H H ri H o ιn cD co o o o θ ri θ ri o σo σι oo cn oo cD cn r-- r- oo co cD in "tf o cM 'tf i cN CM CN i ιH r o (^ o o <^ r^ cD r~ r~ r- r-- - cD i D "tf "tf co ιn ιn Ln i-H rl CN CM CM CM CM CM CM CM iH i-H rH rl rl rH rl rl i-l rl rl rl rH

CN CO CM ι-H ιn θθ r- r~ rl CM ιn rl 1' Cn cθ rH OO CM rH co cθ ri o o r-. ι-H θ CN ri oo cN co τ σ oo ιn cn cM "tf r- ro co m ^■ co ro o r~ r"- m r- cn oo r~ 'tf o ro oo ro r-- ri r- r— CN in ro r- CN cn ri ri σi 'tf cn cM CD ^< ιn "tf ri ri cD r-- 'J - ri ^i' CN ri cD θ co c r-- m 'tf O "tf "tf ^ co r~ ' r- rθ "tf θ co ri cn cN "tf C θ co o oo o o oo ιn cM CM CN ri -tf r- ro co oo oo ro co cn co 'tf ri cn r- m cD 'tf r- cN ^i' m ι-ι cn ro r~ o -q< r- ro r- co

H O ( (^ C N tN O O fl^ (lo o3 ^ n M ^ ln ^ ln w fl (^ι n tl H o o o N M N N ι tn n ιn H O N H N O H σι ι ^ co o ω cn o o H t^ι ιη cn cn cn cn cn cn cn cn cn oo oo co co cn cn cn cn cn cn cr> cn cn cn cn cn σo <-o σo cΛ CΛ CΛ <τi cn σo ^

r c m o 'r ^ 'tf '* 'tf ^ 'tf 'tf "tf ^ ^ ι -n - ιn ιn ιn N7 D co co ιo ιo o ι^ in in in in in in in in in in in in tn in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in

CM CN CM CM CM CM CN CM CM CM CN CN CN CN CM CM CM CM CM CM CM CN CM CM CM CM CM CN CM CM CM CM CM CM CM CM CN CM CN CM CM CM CN Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q

CO CO CO CO O CJ CJ CJ CJ CJ CJ CJ O O O O O O O W ω Cxl Cxl Cxl Cxl Cxl Cxl D D D D D D D D Z Z Z Z Z tftftftftfXXXXDDD H rl H M Ctf S o xi a oS C-J tJ o tf M CtJ -J O OS oS O OS ^ a Hi hi h a a a a a u ω u ϊ s s ϊ ⁽( fl; ri| ιa; fi; ; (i; fl; iι ⁽iι iiι (iι (iι iiι ciι H H H H H H H H a a a Hi a a a ιa o t5 t5 c t3 rt; (< (< (i: J CJ CJ CJ πa i-a i-a

CM rl rl rl CM tf ca cj a cxi co a a Q tf co o tf PQ CJ Q o z tf CQ CJ Q Q uozooυυzozzoozouooo ozυυυoυo tf CQ tf CQ zυυυυυooz o υ o o z o υ υ o z tf o o o z o tf CQ υ ιn ^ ^[^ ro c> o H s. ro ^ u^ ø r^ ∞ r. θ ιH C ro ^ ι ^ r^ ∞

2o22 o 22222222222222 EHoEHoo222 EH EH EHo2 EHo222222 EHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoEHoEH tf tf t_f tf tf tf tf tf tf t_f t_f t_f t_f t_f tf tf tf t_f t_f t_f t_f t_f t_f tf tf

r- e

*s *H

© θ rH oo c cM cn "tf oo oo rH in r~ cD in ( oo c co o ιn oo rH ri "tf CN r ιn Ln cθ ri H 'tf o oo o σι CM in -"tf ^■tf Co o r- O i-H oo cN cn co ro r-

© -

CΛ »-βΪ o r r~ ιH CD CN oo 'tf θo o o cn cM σι oo r~ r rH in oo cD oo o oo oo cD ιn oo ι-H CD CM θ θ ro ro o r-- r~ ι> o ro oo ^■*!• "tf in o co oo oo in cD CM cn o cn

5 .K ^ ιo rn o n o o o o 5ι c(ι (!^ σl o ra ι5l ^ O H H n ^ ιo N o n ^ ω tB <n m m li) o3 ^ ^ ιcι ^ () ιlI N ^ (η ^'ι t^,l ln 'ϊ » ^o ^ ^C 'l' ^

H CM CM CM Co ro ro oo oo oo cM CM CM CM ro cN CM CM ro ro co ro oo M eo ro ro ro ro ro c^ ro oo oo oo oo oo oo oo co M oO "^ υ

AH ooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooo rl rl rl rl l-H rl rl rl rl rl r~ ' ri r CM oo

'tf in iH co l ^ co Λ (η ^ι ^ ^ n ^n H m ffl H ^ ^fi H l l ^ ^ o o « l f t^ w ^ o f^,l o ιn o ^ cD O '3^, ^ o ^ o ^ ι ■ σl l l H co N ( co H o ^ (Λ W ^ H H H O M O ^ ^ O (ι σ) 'J ln Λ ^ "lι w o w o o ( O ^β o ^ N co H ^ (il '* ^iI m o^ ^ ιη 'f Oι cD ^ (Il C^ ( ) P^ α) » σl ^ M H cn o ( M 7 ιn o ^ ιη "f oo "f ^c ^Il ^o » ^ ^ ^ ^ rl l H O N α! 0 "J ln ^ ^• ^ ^ ^ ^ (Jl r- ^ ιn ^ t^ o ln ln tD ι m N ⁽!^ l ιn

'tf 00 r0 C~ 00 r^ 00 lD r~ 00 in CD "tf r0 CM 00 00 000000 "tf in 'tf CM rl CM rl rH rH rl O rH O rH O O o CM o CM rl 00 oo in CM CM CM rl I I I I I 1 1 1 1 1 1 1 1 1 1 1 o ιn ιn o cτi CM ri 'tf ιCMv rιoo

1> Cn iH ∞ n "» n M N en cn cn cn oo

H H H H H N M N M N N N π tη n iη n ^ ^ ^ ^ ^ ^ ^ ^ in in i in in i in in in w ko io io io cβ io ^ h ^ ^ ^ ∞ ω ω ω ω iTi cfi

CO CO CD CO CO CO CO CD CO CO CO CO CD CD CD CD CD CD O ID 10 I" IO CO VD IO CD ID CD CD CO CO CO 'Λ CO CD CO CD CD I-3 CD CD CD ID (N CN CN CM CM CM CN CM CN CM CN CM CM CM CN CN CN CN CN CN CN CN CN CN CN CN CM CM CN CN CM CN CN CN CN CN CN CN C^

Q QQ Q QQ QQQ Q Q QQQ QQ QQQ Q Q Q QQ QQQ QQQ Q Q QQ Q Q Q QQ QQ QQ QQQQQ Q QQ Q QQ Q

DDDDDOOOOOOOtf z s ps es p i- Ha i- Ha i- H ω cxi ω ii cxi p ps ps os os os pS Ha a a ιa a a cn & c- ι- (- c- ciι rti 3 z z z z z z z co c co co co OT co cQ c ps os cs o cocococococococoxxxx xxxxxaa aaaaa tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf Ha H Ha H Ha ι-a H H Ha EH EH EH EH EH EH EH > > > > > > rl CM rl CM rl CM rl CM cj Q α Q tf CD CJ tf co tf CQ CJ Q Q tf CQ CJ tf PQ O CJ tf CQ o o o o o z o o o o o o z o o o o z O O O Z O O U O U Z O O Z o o o o o o o o o o o o o u o o tf o OO "tf in co r~ oo cn o ri cM rO "tf in i in ui i in in io ω iii io w

o2 2 2 2 2 2 22 2 22 2 EHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEH tf tf tf tf tf tf tf tf tf tf tf tf

-

Table I

ATOM 4565 CB LEU D 269 100. 533 -1. 626 176. 869 1. 00 47. 45

ATOM 4566 CG LEU D 269 101. 303 -0. 473 177. 541 1. 00 48. 73

ATOM 4567 CDl LEU D 269 101. 066 -0. 503 179. 041 1. 00 47. 47

ATOM 4568 CD2 LEU D 269 102. 800 -0. 570 177. 240 1. 00 49. 24

ATOM 4569 C LEU D 269 101. 859 -2. 354 174. 861 1. 00 48. 02

ATOM 4570 O LEU D 269 102. 082 -3. 548 175. 052 1. 00 48. 67

ATOM 4571 N GLY D 270 102. 712 -1. 551 174. 230 1. 00 47. 32

ATOM 4572 CA GLY D 270 103. 989 -2. 060 173. 761 1. 00 47. 45

ATOM 4573 C GLY D 270 104. 044 -2. 496 172. 307 1. 00 47. 67

ATOM 4574 O GLY D 270 105. 125 -2. 778 171. 784 1. 00 47. 93

ATOM 4575 N SER D 271 102. 895 -2. 552 171. 643 1. 00 47. 17

ATOM 4576 CA SER D 271 102. 861 -2. ,965 170. 246 1. 00 46. 98

ATOM 4577 CB SER D 271 101. ,416 -3. .160 169. 795 1. ,00 46. 79

ATOM 4578 OG SER D 271 100. ,759 -4. .117 170. 611 1. ,00 50. 01

ATOM 4579 C SER D 271 103. ,562 -1. .964 169. 327 1. ,00 47. 46

ATOM 4580 O SER D 271 104. 065 -0. ,933 169. 770 1. ,00 47. 22

ATOM 4581 N ASN D 272 103. 602 -2. ,288 168. 042 1. ,00 47. 66

ATOM 4582 CA ASN D 272 104. ,220 -1, .425 167. .045 1. .00 48. ,16

ATOM 4583 CB ASN D 272 105. ,418 -2. .118 166. ,394 1, .00 47. ,89

ATOM 4584 CG ASN D 272 106. ,677 -1, .978 167. ,204 1, .00 48. ,55

ATOM 4585 OD1 ASN D 272 107. .266 -0. .901 167. ,263 1. .00 49. .20

ATOM 4586 ND2 ASN D 272 107, ,099 -3, .063 167. .841 1, .00 49. .75

ATOM 4587 C ASN D 272 103. ,179 -1. .127 165. .986 1, .00 48, ,54

ATOM 4588 O ASN D 272 103, ,003 -1, .902 165. .049 1, .00 51. ,19

ATOM 4589 N VAL D 273 102, ,484 -0, .008 166. .133 1. .00 47, ,34

ATOM 4590 CA VAL D 273 101. ,452 0. .368 165. .172 1. .00 47, .18

ATOM 4591 CB VAL D 273 100, .245 1. .014 165, ,909 1. .00 48, ,44

ATOM 4592 CGI VAL D 273 100, .692 2. .319 166. ,584 1. .00 49. .44

ATOM 4593 CG2 VAL D 273 99. .093 1, .269 164. .936 1. .00 47. .73

ATOM 4594 C VAL D 273 101. .989 1, .355 164, ,121 1. .00 45. .31

ATOM 4595 O VAL D 273 102. ,945 2. .090 164. .377 1. .00 45. .17

ATOM 4596 N GLU D 274 101, .385 1, .353 162. .934 1, .00 42, .57

ATOM 4597 CA GLU D 274 101. .778 2 .281 161. .876 1, .00 40, .24

ATOM 4598 CB GLU D 274 102. .807 1 .650 160. .942 1, .00 41, .03

ATOM 4599 CG GLU D 274 102. .204 0, .676 159. .951 1, .00 43, .76

ATOM 4600 CD GLU D 274 103. .232 0. .089 159. .019 1, .00 44, .63

ATOM 4601 OE1 GLU D 274 104. .294 -0. .338 159, .533 1 .00 47 .63

ATOM 4602 OE2 GLU D 274 102. .979 0, .046 157, .789 1 .00 42, .57

ATOM 4603 C GLU D 274 100. .533 2 .673 161 .081 1, .00 37, .93

ATOM 4604 O GLU D 274 99. .781 1 .815 160, .617 1, .00 36, .45

ATOM 4605 N PHE D 275 100. .317 3 .976 160, .934 1 .00 36 .52

ATOM 4606 CA PHE D 275 99, .155 4 .499 160 .210 1 .00 33 .93

ATOM 4607 CB PHE D 275 98, .654 5 .787 160 .860 1 .00 32 .58

ATOM 4608 CG PHE D 275 98, .012 5. .585 162 .206 1 .00 29 .81

ATOM 4609 CDl PHE D 275 96. .732 5 .052 162 .307 1 .00 28 .52

ATOM 4610 CD2 PHE D 275 98, .682 5 .950 163 .373 1 .00 26 .90

ATOM 4611 CE1 PHE D 275 96 .127 4 .893 163 .554 1 .00 30 .09

ATOM 4612 CE2 PHE D 275 98 .088 5 .794 164 .619 1 .00 26 .27

ATOM 4613 CZ PHE D 275 96 .811 5 .267 164 .713 1 .00 28 .01

ATOM 4614 C PHE D 275 99 .465 4 .779 158 .758 1 .00 33 .21

ATOM 4615 O PHE D 275 100 .619 4 .954 158 .380 1 .00 32 .57

ATOM 4616 N MET D 276 98 .414 4 .829 157 .950 1 .00 33 .97

ATOM 4617 CA MET D 276 98 .552 5 .090 156 .529 1 .00 34 .49

ATOM 4618 CB MET D 276 98 .052 3 .923 155 .713 1 .00 38 .18

ATOM 4619 CG MET D 276 98 .799 2 .645 155 .872 1 .00 44 .09 Table !

ATOM 4620 SD MET D 276 98, ,473 1. ,821 154. .327 1. ,00 50. .23

ATOM 4621 CE MET D 276 99. ,686 2. ,703 153. .271 1. ,00 48. ,04

ATOM 4622 C MET D 276 97. ,724 6. ,274 156. .107 1. ,00 34. .32

ATOM 4623 O MET D 276 96, ,730 6. ,619 156. .747 1. .00 32. .03

ATOM 4624 N CYS D 277 98. ,123 6. ,871 154. ,994 1. .00 34. .70

ATOM 4625 CA CYS D 277 97. .408 8. .007 154, .442 1. .00 34. .96

ATOM 4626 C CYS D 277 97. .704 8. .032 152, .943 1. .00 33. .55

ATOM 4627 O CYS D 277 98. .843 8. .224 152. .529 1, .00 34. .70

ATOM 4628 CB CYS D 277 97. ,892 9. .283 155, .108 1. .00 36. .83

ATOM 4629 SG CYS D 277 96. ,863 10, ,744 154. .794 1. .00 39. .87

ATOM 4630 N LYS D 278 96, ,682 7. .820 152, .130 1. .00 31. .82

ATOM 4631 CA LYS D 278 96. .868 7. .799 150. .688 1. .00 30, .45

ATOM 4632 CB LYS D 278 96. ,086 6. .611 150. .107 1, .00 33, .60

ATOM 4633 CG LYS D 278 96. .331 6. .278 148. .628 1. .00 41. .46

ATOM 4634 CD LYS D 278 95. .614 7, ,246 147. .632 1, .00 43. .28

ATOM 4635 CE LYS D 278 95, .477 6. .643 146. .221 1. .00 40, .06

ATOM 4636 NZ LYS D 278 94, .721 5, .342 146. .221 1, .00 39. .77

ATOM 4637 C LYS D 278 96. ,380 9, .128 150. .120 1, ,00 28. .42

ATOM 4638 O LYS D 278 95, .182 9, .425 150. .132 1. .00 27. .77

ATOM 4639 N VAL D 279 97, .316 9, .932 149. .628 1. .00 27. ,51

ATOM 4640 CA VAL D 279 96. .987 11. ,240 149. .078 1. .00 26. .96

ATOM 4641 CB VAL D 279 97. .969 12. .305 149. .565 1. .00 27. .10

ATOM 4642 CGI VAL D 279 97. .531 13. .683 149. .075 1. .00 28. .38

ATOM 4643 CG2 VAL D 279 98. .044 12. .278 151, .066 1. .00 28. ,56

ATOM 4644 C VAL D 279 96. .991 11, .306 147. .560 1, .00 27. .47

ATOM 4645 O VAL D 279 97, .666 10. .528 146. .887 1. .00 27. .46

ATOM 4646 N TYR D 280 96, .213 12, .243 147. .031 1, .00 27. .87

ATOM 4647 CA TYR D 280 96. .140 12. .481 145. .590 1. .00 27, .91

ATOM 4648 CB TYR D 280 94, .879 11, ,896 144. .946 1. .00 25. .61

ATOM 4649 CG TYR D 280 94. .783 12. .292 143. .492 1. .00 20. .03

ATOM 4650 CDl TYR D 280 95. .581 11. .663 142, .538 1. .00 21. .49

ATOM 4651 CE1 TYR D 280 95, .641 12, .113 141, .214 1, .00 20, .60

ATOM 4652 CD2 TYR D 280 94, .016 13, .377 143, .092 1, .00 18, .90

ATOM 4653 CE2 TYR D 280 94. .064 13. .843 141, .766 1, .00 22, .69

ATOM 4654 CZ TYR D 280 94. .894 13. .206 140, .834 1, .00 23, .31

ATOM 4655 OH TYR D 280 95. .053 13. .704 139. .556 1, .00 23. .42

ATOM 4656 C TYR D 280 96, .100 13. .978 145, .338 1 .00 28, .68

ATOM 4657 O TYR D 280 95. .275 14, .692 145. .906 1, .00 30, .82

ATOM 4658 N SER D 281 96. .992 14, .462 144. .493 1. .00 28, .17

ATOM 4659 CA SER D 281 96. .984 15. .870 144. .171 1. .00 28. .04

ATOM 4660 CB SER D 281 97. ,625 16. .709 145. .275 1. .00 28. .85

ATOM 4661 OG SER D 281 97. .563 18, .093 144. .954 1. .00 27. .99

ATOM 4662 C SER D 281 97, .733 16. .050 142. .883 1, .00 27. .96

ATOM 4663 O SER D 281 98, .740 15, .372 142. .645 1, .00 26. .52

ATOM 4664 N ASP D 282 97. ,211 16, .942 142. .040 1. .00 28. .40

ATOM 4665 CA ASP D 282 97. .836 17, .229 140. .764 1, .00 28. .26

ATOM 4666 CB ASP D 282 96. .869 18. .031 139. .871 1. .00 26. .72

ATOM 4667 CG ASP D 282 97. .391 18. .230 138. .437 1. .00 27. .05

ATOM 4668 OD1 ASP D 282 96. .605 18, .670 137, .565 1, .00 23. .35

ATOM 4669 OD2 ASP D 282 98, .584 17, .968 138, .174 1, .00 27, .42

ATOM 4670 C ASP D 282 99, .077 18, .008 141, .190 1, .00 28, .63

ATOM 4671 O ASP D 282 100, .185 17, .485 141. .091 1, .00 31. .59

ATOM 4672 N PRO D 283 98. ,918 19, .246 141. .703 1. .00 27. .45

ATOM 4673 CD PRO D 283 97, ,721 20. .080 141. .912 1. .00 27. ,15

ATOM 4674 CA PRO D 283 100, .122 19. .969 142. .116 1, .00 25. .51 > -3 H

O o o o s o s o H > > ι s o o s s s s s

θ i i

C C M N⁾ co ∞ -^j cn o o o o o o o O O Z O Ω O O O Z O O O O O O O Z O n z n z o π o v. o o o O

D PJ PI O CD CO o o Cl z o n z o n n n n PI Pi O CD D z o n o o D CD CD CO > w PI D CD O O > a I M D to co co O ro D CO o O o CO > CD C o O

«-3 H Ω CD cD cD CD cD CD cD M ri ri ri O 'el ^,Tl ^fO 'c3 1^H 'O CD cD cD Q O cD cD CD cD ^fO' ^ft3 't3 to jo pa 50 JO S .O ^ fd JJOO rl→ tr-' ti-' tr-'ⁱ trr' tir-ⁱ' lt^H-' lp→ ti^H-' ItH-' tt^H-' tl^Hr* p--¹ i tr->i i t^Hr¹ i t^H-" p t-¹ H a rl H aH aH aH H HH HH H H HH 33 ?05 pop^» JOt^^,t t^^,t-^,t-' t-^, t -^, t-^, so ^'50 pα T3 13 O ^lD 2 Z Z Z Z 2 2 2 Z M M H M Pl M B n tn w W W B M IIl K 0I O O O O OOO Z Z ZZ Z Z Z Z Z O OO o o o o oo o α o σ o o σoo oo σ α σ o α σ σ σ σ σo σσ o σoo σ σ σσσ α o oo α σ o o o σ σ σ σ o σ o

M NJ W W J NJ M M M M C M W M f NJ KJ ^ NJ NJ M M M M M M M NJ W M I W CO CO CD CO CO CD CO ∞ CD OO CD CO ∞ OO OO ∞ CO CO CD CO CO OO ∞ ∞ OO CO αO CD CO OO CO OO OO OO C^ a ιo ιo ιo w ιιι ιo iΛ θo ω m cD ω ffl o o: ω o o o o o o o o σι m ft βι (rι oι σι oι σι σι uι uι u n w ijι w Λ Λ ι-. ι-, Λ ιb ^

r' ' l-' r' l-' l-' r' r' r' r' r' l-' r' r' r' r' r' r' H' H' l-' H' l-' H' H' H' H' l-' r' l

O CD O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O CO O O O O O O O O O O O O CD O CD CD CO lD O O r' r' r' r' O r' l-' J CO CO NJ Ki r' W tO I-' l-' ^J H M O H Ul *, J iMil M N H N H O IO id Λ il- il- iI- W H lfl O OO CD w w iB m o iD M CD H αi fc n w w o H m w ω ω ω U o u o o w o o ω ω o w tji i i φ m ω iD M w ω iD

J H H IJl ιli M fc Λ H θ ω 0 Λ UI U M M lJ 10 M fe O * tΛ ^ H ~J N α! Λ fc O (J H W ) ^ Ji M θ ω θ lfl ) C0 Λ W U) l0 O I\) O Λ H M O H (S M Λ l (J> 1 ^ IJl * CD U H μ Λ m H tD O O lO sl W ^ lD ή O U ^ W W W ^ H m θ0 1 H lD m iO M M Λ CO Ul lθ W M lll M

H H t M H H H M M M H W Ivl H' M P μ μ μ μ μ μ M H H H i-Η H μ p μ p fo w

H O O O I-' W .& il-. I I o o iD -J ^J c cn c c ω Λ ω j-. c vKD OJ O H H lC O O lC lO vl oo ui o oo m o o tc σi m m co ifl co io co iD H μ m uι w αι oo ~j θ (» μ ω μ o ^ ιo J t μ o ω o Λ (» o μ o (j\ iv) N) H W i Λ O O Ul M lϋ O N Λ lO NJ O N M CO ω O O ω o ω H W o m μ oo o w o co iD it! M u ^ i£) μ ι o co iβ Λ θ N M ii) (ii ιis. ω (Ai φ ω ifl W NJ O l O Λ CJ O l CD O iC σi -J -J O O r' ^l O I ^J Λ ui iβ iD io co o ii- o ui co M tji ui M O P ω ui ω H i-i ω io -J ϋi ib i-i σi σi N) co ui o o ici Λ Ji σi O Λ Co ω H ω o iϋ oo io ω M W O μ μ μ μ μ μ ' r' l-^H r' r' ' H' H' r' ' H' r' H' ' r' ' l-^H r' r' r' H ' r' ' l-^H I-^H Hⁱ Hⁱ H' H' Hⁱ l-' l-' l (^ l l I <Ti c OO 1 l l CTN Ul l l l Ul Jl l UI 1 l Ul l l Ul 1 l Ul l Ul CJl l l U1 ιl^ J-' ^ m o co ιo ιo o θ Φ Cθ cD w o iD φ θo θ Λ ^ w μ W ι-. ω u M N) M Λ b Λ ) ω o ιo ω o co ω oι m (Λ (Λ b M U U) fe * U ι-. ω M M w Ul O l w μ u o3 ω

0D

CD o oo io w o i ω o l-H l-i Hi I-^{1 1} r" r¹ μ μ μ μ μ μ μ μ

0000000000000000000000000000000000000000000000000000000 0000000000000000000000000000000000000000000000000000000

M N} NJ NJ C I\3 C W N3 ω w ω ω ω u t^ ω ^ή Λ oi w m o o σi m σi Λ o ω μ u M u o o o o uno M μ α) H co w Λ O ffi ii- ω M io cri cD iji o

ri ro r- o oo ιn σ> oo r- ro co co r~ ri "tf 'tf o r- r~ o cθ 'tf co r-- co o cM r~- m ιn «tf CN cri rH cM in r-- oo cN o m r- oo cn cN CD m cN r~ c oo cn m co cn co r- O O CM CD "tf in rl "tf CM C0 00 rl 00 ri m cM CN Oi ri m r- oo oo co oo co ri cn o r-- m c3θ cM co ri oo oo o oθ 'tf in r~ 'tf CM m oo oo ^r σι o

'tf i -tf CM in cD i m in r-- H ^^ ^ ιo σι M H (Λ ^ ^ co ^^ n ι ιil r• o c^ι O H C t» rl ι ι σl H ι ^l H o o ^N P^ ιn (η ffl ffl ^ l H H tD

CN C CM CM CM CN CM CM CM CN ro cN CN CN CN oo oo oo oo ro c ro oo oo oo oO 'T -^ ^ ^ -w oo oo oo ro co cN ro oo ro ro ro r ro r M ooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H rl rl rl rl rl rl rl 'tf CM CN O rO CD 'tf CN in oO CD OO CN CD OO O O O Cn CM CM r- OO m OO OO CD ri o co r- oo co o 'tf CM in ri c o o in σi 'tf 'tf m in cn ri c ^j' CM O 00 CM r-- Ln 'tf r~ 00 CD CN CM CD CM CO 'J' Ln C0 CM rl "tf '3< CD r~ 00 rl O in CD CM O "tf CD 00 f -q< r- CD CD rl 00 CM CD ιn rl O CM CM r0 r0 CM C0 CM CD 00 in < r- r~ cθ "tf cn rθ Ln oo r~ θ ri co ιn rH cN ri cN rH CM ri o r '}' C cn Ln -o ri oo -tf CD cN e m o co m co cN ri ri ri r- r- CM O r^ cN O r- o in cM cn r^ r^ c ∞ ιH C CN oo ro o c o "tf 'tf Ω t-~ co cn o ri cN co cD ∞ cn ∞ r-- co r~ ιn ιn θ r^ in i ιn in VD lO CD CD lO IO CD <O lO CD O CO CO CD ι~ r~ r~- CD CD CD D lO CD CO CO CO CD ι^ r~ CO CD lO D ^ iH rl rl rl rH i→ rH rl rl iH rl rH iH iH iH iH iH rH i-H rH rH rH rl rH iH iH rl iH rH iH rl rH rl rl iH iH iH iH iH rl H

O CD 00 O CN -"tf CN r-- «tf rH ( cMro ^ o r~ CD in r-- 'i^| o co fθ 'a' iD oo o cM 'tf o rθ ri "tf ^r ιn oo CM r^ cTi 'tf r- oo r-- CM r- cN cn rH «tf cn cM ri θ rH oo

CM ro r~ ro o r- so rl rl rl 'tf CO OO Cn rl in iH r-- CM CD r-- lTl Ln O rl O CO CD in 'tf OO CO OO rH C30 -tf o cn ri cD (T> o r- oo cn r-- m oo r~ m ιn cD ri cn 'j' r~ CM in cn oo ro r- ^•^ ιn σ> co r-~ "tf 'tf oo o co ιn oo ri "tf θ ri oo r-- 'j^ι r-- cn o o r- ιn "tf 'r cM "tf m cθ ri σι cn r-- m oo oo o cyι cM CM θ r~ cn r- rH cn o oi m oo ^ in ^ in w ^p- r- ffl Hiⁱ ci v ^ rn N H ri o in ifi f in i in v i^ r- in in "tf o o oo CTN r- r- co in "tf 'J¹ 'tf r co CD Γ~ oo oo o oo rl CM CN rl rl rl rl rl rl rl rl rl CM rl ro oo cN in cM oo cM in oo co fO ri ro cD rH co oo r- co ro o -tf CD CM CD CD in r- ri ri oo oo -^q' ri o o in oo σi co 'tf CN cn cn co o co cM ri cN co ro r- o oo -tf ^r cN θ cn "tf CN co o co co ιn ri r-- "tf ro r- oo cn c oo cD ιn ι~ ro oo n "tf oo ιn cn oo cM cn ri ιn '^^, ιn ri oo vD CN θ ro o oo r-- ιn co r ri ιn r-- o o cD OO CM ri o co r— CM O cn cN CO "tf co oo o cn ri ri vD oo o m H r- o cD "tf ro cM CM oo 'q^, O ri o o oo cM m oo ro in cD m o 'tf oo m r-- cD ri cN θ co co ιH CN θ cn ∞ cn o r-- cn ∞ cn ∞ cn cn cn cn o co co i-D io -'r '* o 'tf co ro co vD o o o cn cn o o o cn cn cn o cn cn cn cn cn cn cn cn cn o cn cn cn cn cn cn cn cn cn cn cn cn cn cn en cn cn o o o o o o o o o o o o o o o o o rl rl rl rl rl rl rl rH rH rl rl rl rl rl rl rl rl rl i-H rl rl rl rH rl

σ^ σ^ cn cn cn cn o o o o o o o o ri iH rH ri iH rH iH ri rH CM CM CM CM CM CM cM CM CM CM co oo oo oo oo oo oo cn cn cn cn cn cTi cn cn cn o o o o o o oa ω iri m ou ∞ oi oi Λ Oi ^βi oi oi oi m i^ji Λ tii Λ ffi cii Λ m oi Φ oi oi oi oi tJi σi m oi o o o o o o o o o o o o o o o o ri H ri ri ri H

CM CM CM CN CM CM CM CM CM CM CN CM CN CN CM CM CM CM CM CM CM CN CM CM CN CN CN CM CN CM CN CM CM CO n OO OO n rO CO m r^ Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q P Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q D Q Q Q Q Q Q Q Q Q Q Q Q Q Q Cxl Cxl H H rl CM 00 CM rl CM CM rl rl CM rl CM rl CN CN rl rl fxi co M a tf CO CJ Q Q tf CO O Q Cxl N tf CQ O Q Q Cx] Cx] υ υ tf CQ CJ CJ tf CQ CJ Q ω Cxl z υ υ υ u CJ CJ Q

O z υ u CJ o o z u υ υ u υ z o o z uoυυz υz υ o tf CO z oυoυoozoouoozυ o z υ o υ o o

O H t^ι M 9 ι Φ tD ⁽Λ O H ^[^ι ⁽η ^ l ^o ω ιJι o H ^l ⁽η ^ ln l0 ιIl O\ O H tι ⁽η "^' ιn ω ^ o ft O H N n ^ ln w ^ ro w o r^ t\l n >I co co eo eo r r r <^ ^«tf ^ ^ⁱ "tf ^ '^ "tf ^«tf "tf "tf iJθ ιn ιn ιn ιn ιn ιn ιn ιn ιn cD D CD < ⁾ iD co o ιo vD co r~ r^

^ 'tf ^ "tf '3" "tf "tf ^ ^ "tf 'i^l '^ 'tf '^ ^ 'tf 'tf ^r 'tf "tf 'tf ^ "tf "tf "tf ^ ^ ^ 'tf 'tf ^ "tf ^«tf 'tf '^ '^ 'ϊi 'r i^l 'tf ^,^ 'tf 'tf 'i "tf ^

o2o2o2 22222222 tfEHt_f ^H EtfHo222 HoH EoHoHoEH HooH EoHoH EoHoEH

in cM m cM r- m CD in in CM "tf rl σι cM ro o ro ro en CM «tf m CM en N. 1* 'tf T T 00 LO "tf O LO LO 00 so oo oo oo oo oo oo oo oo oo ro oo oo oo OO OO O OO O O OO OO OO OO O OO O O O O OO o ω ^ ^ tη (ι t» o t r^ H m l (^ o ^ l ω ω ^ o ιη ^ ^ l (η N ^cι a! (l co ^a ( n <^ (Jl tι ω l H m ω ln o co ^o cD m ^ m "l' O fl

■^ o o ι o '^ oj ιn r ιH in oo D _ιH in ιn cn cΛ oo c c c co c co «tf CD ιn "tf CM rH CN "tf in θ ιH in r~ ιn ιn o cN σ> ι^ r_^ cM CM CN r ιn ro oo cn o co ιn σι σ^ r-- cn σι ιn ιn r- oo ro ιn oo ιn cD -tf ri o oo cN ιH ι^ oo ro o cD ro cM θ CD oo c^

^ in 'tf -tf -tf i in io cN C rH o cn co oo r- r^ cn o^ oo r^ oo c r^ D io in ^ ro r 'tf c C CM C rH iH i-H O c^ cD co io i-D iD CD co cD CD iD CD CD in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in iH rl _l-H i-H rH iH rH iH iH rH rl iH iH iH iH iH rH rH rl rH rH iH rH iH iH rH rH rl rl rl iH iH rH rH r^

00 -^ CM 00 OO f r^»~- ri o ιn cM Co o ιn σι θ ι-H θθ oo o ∞ ιH o vD ^ r-- ιH r-- θ ιH CM CM r-- ri ιn ιn 'tf "tf cn r^ ιn "tf cn ri o o cD co r- in o oo r- oo

ID in f H H r~- m cθ ri co m r~ cn ro cD θ ri m oo cN CD cD o o r- oo o cN oo co ri cM ri cn co ιn m co LO LO CO OO O rl OO 'tf r- ' OO ri r- in rH 'tf

LO CD -tf CN O O O OmO o -^ 't_f C cD ro oo c r_^ r r- oo oD CM ^ι^, o cD ιn cD 'r cN in r-- CN CM 'tf CM CN CD r-- ■tf CD CD oo o r-- co ro r-- r- r-- oo cD t-- m r^ co co in T (η n ^ N ^ n •^^ ^ « (^ι o o oo ι l ιn ω o^ co w l-) lB ^c ιo ^o ^- co ^ co ^ ω oo ^ oo (!0 (3l ^D ιn ^£l ^£^ ^l) ^ oo r^ 'tf ro 'tf ro ro oo cM rH rl rl rl rl rl rl rH rl rH rl rl rl rl rl i-H rl rl rl rl rl rl rl rl rl rH rl rl rH rH rl rl rl rl rl rH rl rl rl rl rl ln o N co c^^ ιη ω ln m m o '? lD tn ω (! <f H ιn ^n ιn l a) (η ^D H "|ι ^ ^ "f l* N « ^ ln ^ tJl (^ι ∞ l •» H oo ^ ^ o N ^ H co oo r~ oo oo O H ^ w ol t^l m H ^ ^ ^ ^ H * <ι ^ ιn l (^ι tJl co m ^ι l "lι r■ ^ ιn p^ o ^ li> ln ^ι ^ ιn H ^!> ι "J l H ^- o^ ^ o ιO H O ιn r- oo co ID ro ra σι ro d H ^ι o o m o ^ H o^ ι ω ιn ^ ln ω (η ln tD H N "lι ι ^l N N (Jl ^l (l ln l ιn to oo ^l l n o o ιn ^ lcι ^B ln ^ rl "tf in r~ in co m "t_f -O _f r cN "t_{f L}o r~ _LO _CD CD iD r-- r~ "tf CD CD CD in co r- oo cD r- cD oo r- en o ri ri cM θ "tf D "tf t< ιn -cr «tf 'r ιn ιn cD o 'tf CN ri θ ri c o o o o o o o o o o o o o o o ooooooooooooooooo rl rl rl rl H rl H H rl rl rl H rl rH rl rl rH rl rl rl O rH rl rl rl HH ri HH ri H H H H HH HH ri H H Hri H H

O O rl rH rl rH rH rH rH ιH CN CN CM CM CM CM CM CM CM r0 C0 00 00 r 00 00 ^ ^ ^ 'tf 'tf in ιn ιn ιn CD C0 CD CD CD C0 CD r~ r~

H H H H H H H H H rl H H H H H H H H ri ri ri ri H H H H H H H H H H H H H H H H H H H H H H H H H H rl H ri ri rt H d ro c^ oo oo ro oo oo oo oo oo oo oo oo ro ro ro oo oo oo oo co ro ro co ro ro ro oo ro oo oo ro co ro n oo ro ro oo oo oo oo oo

Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q D Q Q Q D Q D Q Q Q D Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q D Q Q Q Q Q Q C-I C-I D O D O D D D D CO CO CO CO W CO CO CO CO PS Λ PS PS CI PS C-; tf tf tf tf x x x H H H H H H H z z z z z z z z p os os os

Ha H xi xi cxi xi i xi i cxi x x x x x x x x x a a a a a a a H H H Ha i-a H Ha Ha tf tf tf tf tf tf tf co co co co c co co c a a a

H H ni a a ^ a a a a a a a a a a a a a M H ^ n h ri tf tf tf tf CJ O CJ CJ > > > > > > > tf tf tf tf tf tf tf tf H EH fH EH EH rl CM rl CM rl CM rl CM rl CM tf CQ CJ Q Q tf OQ CJ Q Cxl lSl tf CD CJ O tf CQ tf tf OQ CJ CJ tf OQ Q Q tf CQ CJ CJ oozυouυυoozooouυzoozυυoυuozuυoozoυozoυυυυozυoυozυozυooυ ι ^ ^ o^ w o H N n ^ l w ^ co m o H N (n ^ ι » to σl O H (^l t ^ ln w ^ co σι O H N (n 'i' ln w p- co m o H f tn v ι ω !D tJl ω tD θ3 m ω (3i oι m m (j) m m w m m o o o o o o o o o θ H H ιH H H H H H H H N tNi N N N N N N N θN n n tn tη n ι») t») t (η tη ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ω ω ra ra oo ω ω o^ oo ω co ω ∞ ω ω ω co m ω ω m ω ω o oo !n ω ω oo ω ω m ω ω ω ω ω α) ω ra

OS rH se rH O o 22oo2o2o2o2o22o2o2o2o2oo22oo22o2oo22oo22o2oo22o2oo2o2o22o2o2oo2o22o2o2oo22oo22oo22o2oo22o2oo22o2oo22o2o2o2o2o

O tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

HSJ ln ^ o ω o ^ N m ^ ιD n H l 9 a ■a' ln ln ln H ^ ω o ^o o π (1 H f fl^ ι n ^ o tη ι W "l^ι ^ * a N ^ (O ffl O N tΛ O ^ >» o <l^, ^• o3 f ■Q ^ ω fo σl lO H Φ lJ) "» co o fO H ω oo o l» CD ^ (^l ln ^ w oo w σι o ιD m l n ^ N H H H m ^o ol O N o ω ^ ^l ln ln ^o ^l H n l^ r^

© © a co m r-- r-- r- cn ri ιo co ιo ιn oθ ' CN "tf L co r-~ r-- cn oo r-- cn co r^

CΛ ro ro oo oo ro rO 'tf ro oo oo oo ro r ro ro oo oo oo ro e 'tf ^ ^ ^ oo ro ro oo oo oo oo cM oo oo oo oo oo ro ro r ro oo ro ro oo o^

£ H ooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooo J

0- rH rl rl rl rl rl rl rl rl rl

^ π m ^ι ^ w ^ "n lD co ^ O f lD ιn ^o ^ rt ιo <» ι^l H ^O (^l O ιn μ ( ι al o (Λ o ι t»l (η l (Λ l ^I⁾ o m ^ι' lfl « oo ι H ιn o o tO "l^, ι ft r~ o r-^ ιn n "tf io iO oo cM cn ri r^ 'tf θ o σι CM co σι o ι^ 'r ιn cN cn σι r "tf C ro r~ r 'tf r ιn α^ f-~ r^

"tf 'T 'tf ri cM θ cn ιH θ rH cn iD r ro cM C CD co c r- Ln 'tf CN θ oo r r-- cD CD o "tf r--- r '^ cθ ri 'r oo vo r ro c ιH θ θ co rH CN θ n oo oo oo r~ o o <Λ c cn oo oo t^ r~ ι-H rH CN Cθ ^ ^ ι cD ^ 'r ιn r "tf o ι D "tf "tf co c^ ιn ιn ιn ιn ιn ι "tf in ιn ιn "tf '^ 'r '^ '^ ιn ι 'r 'tf " "tf ^ -* 'tf i ιn ιn ι ιn t ι^ rH H H rH rH rH H rt rl rH iH rl iH H rl i-H iH rH rH rt rH iH rl rH rH H rH rl iH H rl rl i-H iH rl rH rl rl iH H rH rl rH r^ l M O cn ( ^ m ^ ^ι w (Jl ^ O N ln m σ^ N ^ H O (n r~ ω H ^ι oD H m ln ω ^ n ^ t ^ W H O ^ ω ln ^ ιfl O l H n o1 σl ω ^ r^ H («l

•^ ro r~ o o cM in ιn o o ιn ιH r~ co ι-H in ιn ιn ιH rθ 'tf CD CD CD 'r oo cN CN r~ co ι~ co ιn '? c^ >tf CN oo ^ rø

CD CM cn co cn r^ ι ιH 'T "tf oo ri ι eM θ ro r~ r-~ r c «tf CM ri cD oo cn '^ θ rH i o ιH CM i^ o r~ ιn co oo oo o^ n "» M ( H N H N N H N n "I_' ^ 0 (!l O ∞ oo oo m co ^ Φ ^o co ra ^Λ <n cJl O ∞ 03 ^ 0 H N N π Φ o m tn ^ ra ra ^ co ^ lβ lB ^o <^ o in cn co i→ co o r^ cM 'tf CD 'tf D r^ ^ i→ co in co 'r in o r- in in r^ o c ri o^ co r^ co ro cD iO iH eN σi in r^

^o ω O H lD tO ( ^ w ιn H ^ι oo _^^ ^ ^ ^ι ∞ ^ H O N M co "i^ l£) ^ ιIl ^ '^ ω (» ω "l' « 'r ^ ιx) tJl ^ co ω l N ^£^| l n o m H ■a' ^ ^ ιB rπ ^ w cD O (O O ln N ω t^l Λ n N ( (η l o o H ^ H O H ln H ιη σι n ^ N <I^ l ^ M C m ιn m m o w (η o co ι ^ (η o ffl H l ln o oo rl O rl CM rl cn cn oo i— co co m co r- co oo oo o o r~ oo oo oo oo rl rl O CM O 00 CN ro rt O rl O O O O O O O O O O O O rl rl O O o o o O O O O O O O O rl rl rl rl rl rl rl rl

ra eθ W 10i m (J1010\ O O O O O O O O H H H H H H H H H tN M I M N N N N r iη (^,l tn rl t^ll m f1 ^ 'r "l^, ^ HI^, ^ 7 'if <» ιn ιn in ro oo ro oo oo ro ro ro oo oo ro ro oo oo n ro oo ro oo oo ro ro m oo oo oo oo oo n oo oo oo ro ro m ro oo n co Q Q Q Q Q Q Q Q Q Q Q Q Q Q O Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q D Q Q D α Q Q Q Q Q Q Q Q α Q Q Q Q α Q

C-l pS pS CS OS oS CtS pS pS Pj C CM αi CM αi CM CM C CO C C C C CO CO CO D D D D D D D D a a a a a c coci fcio eco rcon rco tcno rcon rco Xx Xx Xx Xx xx xx X x X x a πl πl H! HI HI IJ HI Hi w w H H W w w H H ta a a i ia Hi Hi Hi H EH EH EH Eπ H tf tf tf tf tf tf tf tf i-a Ha H Ha Ha H HI .-a CJ CJ CJ CJ O CJ CJ O CJ 2 222 2 2 2 2 CJ CJ CJ CJ CJ O CJ CJ CJ tf co CJ a ω tsi oozo tf CoQ CoJ Oυυoz tfυCυQ CoJ QooQ tf CQ α Q tf CO CJ Q Cx] tf CQ CJ Q Cx] Cxl tf CQ o o z υ o υ υ u z o z o υ υ υ O O O z o υ o co υ υ o z o υ υ υ o o o o z υ υ

_"*

■tf ω ω T CΛ CM •_tf cn co ri σι CM m σN ri cθ "tf CM m ιn ri ri 'tf θo ro r-- rH ro r- r-- r ιn cn σi cD r~- σi cD oo co o c ιn 3^ c cn 'tf r- cM 'tf rH 'tf ri r~ i m o Mti oo r- ■tf cn n o in co r- r^ r- ro oo cn cD cn ro oo ri t^ ro in cM ^r o r cD cM r c i o ri r~ r- ro o ri D co cD cM c "!]i c "tf co co o \D

OJ CM CD CD Γ~ OO OO OO Γ~ OO OO OO o co c o σN ιH CM 'j 'tf i t^ cD c cN c θ rH cM 'tf ^ cD r- oo θ (η Ln cD r-- o o oo σι oo ι^ θ ιH rH CM CM θ ro oo ro co oo ro ro ro ro ro oo oo ^ 'T '^ ι ^ ιn ιn ^,t_f 't_f 'r ^ "t_f "t_f "t_f ro ι ιn ιn ιn ιn ιn ι tn D cD io D iD co D in ιn ιn ι ιn cD co co cD cD CD CD ooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooo υ H rl rl rH rl rl rl rl rl rl rl rl oo cM co cD in m cn oo r- oo H o ιn ^ ^ m ^ ln ^o o « ω ιn M M^| H lO ι l ( o ι£ι r^ ^■ ιTι ^ O H ιJl lo ^ H O fι ^^ ^ o ιn ^ ^ t^,l Λ ^- N: cn co r- ri ro rO rH oo ri co o ^ l _H ^ tD ^D co l ( ln H ιn o >I^, ^^ t') H « _N ln ^ « ln o!) ^- ^D (η r^ o f l ι (^ϊl W oo ^O () 'l^, oo ιD ^ ^D rl CN OO OO Cn CM Cn CM rH CO ^ ln t ffl ln p^ cl o ^ oo M ^o o ^£l O (D H ^D ^£l O l (n o <B m ^ ln o co ^ ^ o ^ o ^ t^ι ιn ln H H ln tM Ol ιo ^ ^ ^ ra o o ^ι ^ (l H H H t^l H O (Λ O (J co (^ ^ _'» ^ ω ιo ^D ιo l0 r- ^ ιJl m ol O H ( t') m l M H N H (Il H (η "f ^ ιn ^O ln ln in in in in in co co io co io co io io io co io in co in in co co co co vo cD co w co co io ^ co io co io r^ r^ i^ r- rl rH rH rH iH iH iH rH rl rl i-H iH iH iH rH rH rl rl iH iH iH rH rH rH i-H iH rH rH rH rH rl iH rl rH rH iH rH H iH rl H rH -o o r-- ιH r--- co r- oo <M in ∞ ro cn ιn _ιH iD ιn ro ιc o σi ιn θ H θi n (o q' tn ω ιθ r- t- oo Λ σι ιn m ιn M^, τ n ι^, ( CN' (^γ) "j ιn f ^^, "d' m ccι t^ ( i H M N N H CM O O O O O rl CM rl CN CN CM O CN ri rO rO OO in OO I I in i^ o in 'tf co ^ co i^ in 'tf O 'j' i^ oo ^ cD in 'tf cn cN CD -tf co co cM O ri o cM ri rH CN in D cjo oo r^ oo oo in in i^

Λ w ^ ιn iD '» oo σi ( iD iD θ H i ^ ω H N n o H i co ^ ιη H oo ι '* ι3i H » (η o N "i^, ιn ιo ^ "f tJi ^ ^ co ifl ^ N N ^ (Λ θ rH in r~ r~ cN ιH in ∞ 'tf in r-- co cN co vo o eN oo oo ro cn ιo cD cM co ro co ro cθ !n oo ∞ i o 'tf CN C CM C o rH ro cM 'r in cD CD t^ cD io vo in i -tf -^ co cM i co iO 'H iD r- co r^ r^ cD CD r^ o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o

H H H H H ri ri ri ri ri H H ri H H H H H H H H H H H H H H H H H H H rl H H H H H H H H H H H rl H rl H H H H H H H H

ιn l ln ιn w w ^o ιD ^o ιi ^D ^B ^ ^ ^ ^ ^ ^ m ι ι m co co α3 ra oo σl Ol ⁽Jl tJl <Jl o o o o o o o o H H H H H H H < l (^ι t^ι c:

CM CM CM CM CM CM CM CM CM CM CM CM l CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CO rO OO rO n oo oo oo ro co ro oo oo oo oo oo oo oo oo oo oo ro ro co eo ro ro ro ro ro oo ro eo oo oo ro oo oo oo oo m ro oo oo oo oo ro oo n Q Q Q a Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q O Q Q D Q Q D Q a Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q jaaaD DD D D D CO CO CO CO CO CO CO CO CO CO D D D D D D D D CJ CJ O CJ CJ Z Z Z Z Z Z Z Z HI PS OS PS cύ a tf tf tf tf C^χl Cχl Cχl C-I Cχl C-] u W H H H H H H H H H H ω ω ω ω mim M Bi it Bi i- iS n w tβ tn n w w to rt; Cxl Cxl Cxl Cx] ω

> > > > Hi Hi a Hi Hi Hi a H H a a a a a a a Ha H Ha Ha H H H Ha tf tf tf tf tf tf tf tf tf tf tf tf tf > co co co co co rl CM rl CM CN rl rl CM rl CM rl CM rl CM

CυJ CυJoozo tfo CQυJ ao Qυυ tf CQ CJ Q Q Cxl dl tf CQ CJ Q Q tf o o z υoυυzυzυoz tf CQ O ^{Q Q} tf CO CJ CJ tf CQ CJ υ υ o o o υ o z υ υ υ o z υooozoozυυoυoozoooυ

Table !

ATOM 4950 0 SER D 332 100. ,512 4. ,522 174. ,845 1. 00 64. 37

ATOM 4951 N PHE D 333 100. ,397 3. ,754 176. ,946 1. 00 64. 59

ATOM 4952 CA PHE D 333 99. ,122 4. ,413 177. ,199 1. 00 65. 42

ATOM 4953 CB PHE D 333 98. .744 4. ,276 178. ,676 1. .00 68. ,43

ATOM 4954 CG PHE D 333 98. .278 2. ,896 179. 054 1. ,00 72. ,42

ATOM 4955 CDl PHE D 333 98. .169 2. .526 180. ,391 1. ,00 73. .24

ATOM 4956 CD2 PHE D 333 97. .933 1, .966 178. .069 1. ,00 74. .01

ATOM 4957 CE1 PHE D 333 97, .725 1. .252 180. .745 1. ,00 73. ,82

ATOM 4958 CE2 PHE D 333 97, .488 0, .691 178. .413 1. ,00 74. .79

ATOM 4959 CZ PHE D 333 97. .384 0. .334 179. .754 1. ,00 74. .53

ATOM 4960 C PHE D 333 99. .180 5. .882 176. .809 1. ,00 64. .25

ATOM 4961 0 PHE D 333 98, .161 6, .494 176. .488 1. .00 63, .25

ATOM 4962 N GLU D 334 100, .386 6, .436 176. .830 1. .00 63. .41

ATOM 4963 CA GLU D 334 100, .591 7, .835 176. .486 1. .00 62. .79

ATOM 4964 CB GLU D 334 102, ,032 8, .235 176, .794 1, ,00 65. .85

ATOM 4965 CG GLU D 334 102. ,503 7, .874 178. .195 1. .00 69, ,95

ATOM 4966 CD GLU D 334 104, .013 8, .031 178. .345 1. .00 73. ,26

ATOM 4967 OEl GLU D 334 104, .540 7. .773 179, .457 1, .00 73. .50

ATOM 4968 OE2 GLU D 334 104, ,669 8. .410 177, .342 1, .00 73. .62

ATOM 4969 C GLU D 334 100. .293 8. .067 175, .002 1, .00 59. ,92

ATOM 4970 0 GLU D 334 99. .578 9. .003 174, .643 1, ,00 59. .28

ATOM 4971 N ASP D 335 100. .839 7. .198 174, .154 1, ,00 55. .93

ATOM 4972 CA ASP D 335 100. ,669 7. .287 172. .712 1. ,00 51. .63

ATOM 4973 CB ASP D 335 101. .515 6. .217 172, .037 1. .00 49. .63

ATOM 4974 CG ASP D 335 102. .974 6. .327 172. .406 1. ,00 48. .72

ATOM 4975 OD1 ASP D 335 103. .514 7. .444 172. .311 1. .00 46. .64

ATOM 4976 OD2 ASP D 335 103. .584 5. .303 172. ,790 1. ,00 50. .29

ATOM 4977 C ASP D 335 99. .224 7. .183 172. .239 1. .00 50. .20

ATOM 4978 0 ASP D 335 98. .923 7. .478 171. .079 1. .00 50. .69

ATOM 4979 N ALA D 336 98. .327 6, .764 173, .123 1. .00 47. .17

ATOM 4980 CA ALA D 336 96. .924 6, .659 172, .750 1. .00 44. .10

ATOM 4981 CB ALA D 336 96. .119 6. .160 173, .923 1. .00 44, .65

ATOM 4982 C ALA D 336 96. .448 8, .050 172. .331 1. .00 42, .08

ATOM 4983 0 ALA D 336 97. .047 9. .059 172. .709 1. .00 42. .12

ATOM 4984 N GLY D 337 95, .384 8. .113 171. .544 1. .00 39. .09

ATOM 4985 CA GLY D 337 94, .900 9. .406 171, .116 1, .00 36, .28

ATOM 4986 C GLY D 337 94. .650 9, .494 169. .627 1, .00 35, .30

ATOM 4987 0 GLY D 337 94. .873 8, .550 168. .874 1. .00 37, .23

ATOM 4988 N GLU D 338 94. .199 10, ,661 169, .203 1. .00 34, .06

ATOM 4989 CA GLU D 338 93, ,864 10. .928 167. .819 1. .00 31, .79

ATOM 4990 CB GLU D 338 92. ,743 11. .964 167. .823 1. ,00 32. .76

ATOM 4991 CG GLU D 338 92. .136 12. .358 166. .515 1. .00 35, .47

ATOM 4992 CD GLU D 338 90, ,919 13, .237 166. .746 1. .00 38. .92

ATOM 4993 OEl GLU D 338 90, .910 13, .990 167. .750 1. .00 40, .52

ATOM 4994 OE2 GLU D 338 89. .972 13, .183 165. .937 1. .00 40, .80

ATOM 4995 C GLU D 338 95, ,058 11, .401 166. .987 1. .00 30, .61

ATOM 4996 0 GLU D 338 95. ,751 12. .362 167. .336 1. .00 28, .27

ATOM 4997 N TYR D 339 95. ,301 10. ,701 165. .886 1. .00 29, .87

ATOM 4998 CA TYR D 339 96. ,388 11, .062 164. .989 1. .00 30, .24

ATOM 4999 CB TYR D 339 97. ,305 9. .865 164. .711 1, .00 30, .60

ATOM 5000 CG TYR D 339 98. ,156 9, .495 165. .893 1, .00 31, .84

ATOM 5001 CDl TYR D 339 97. ,613 8. .807 166. .984 1. .00 33, .22

ATOM 5002 CE1 TYR D 339 98. ,365 8. .561 168. .127 1. .00 35. .77

ATOM 5003 CD2 TYR D 339 99. ,478 9. .917 165. .970 1. ,00 33. .47

ATOM 5004 CE2 TYR D 339 100. ,242 9. .683 167. .104 1. .00 36. .30 OO rl -q< oo o cfι o o o o

ιn ^fl « H ri oo cn r- oo ro ιo r-- oo co co co oo cM "tf r-- 'tf O N βi n ^ in N in ci f ^ N Oi o ^ o Ono in w in N ^ o r^ c r- H ΗP in oMo ci n H f iβ o cM in σi ri cn co ri T CM ri cn cM CM CM in ^■tf ro o σ^ o o o -tf cn cD '^ c r^ '^ o D in rH 'r σ^ co o ∞ oo co cM CM i σi ri in c H O oo cM co cD o co m oMO H in ^ d rno o N ^ ^ Λ "tf CD θθ ιH r-- "tf r-~ ( rH rH i r^ ^ D rH co cn ιn oo cD co ^ c -^ t-~ ri oo o o oo c "tf "tf in co ιn cM cn co _rH θ CN rθ 't_f 't_f m ro oo m ro ι^, "tf ι-H CN m cD r- oo crι r~ cD CD r- r— CD oo oo cn o ri θ rt cN ri ri CM θ c "tf "tf ⁽o cD CD co r~- ιn ιn 'tf 'tf '^ι^, cθ Lθ t l ^ (O W ^ ^ Ol o ^ ffl ^ N n (Il ^ ω Λ ^ H v H (n oo o o rl ln t^ι o o to ι o o ft O Λ l H l ll) ^ϊl H o H (^^ ιfl H O 'J ^β ( ι c tn ^■ι^ ln H ln » ^ tn ^ c^l "!^, ln ^ m ιn m M c N ^ ln o ^l H ro H ^fl H O ^ ^ ^ ^ M ( ln r- ^o ( o l ln o ^ ln ⁽Il l o ^ σl 0 ^o o ιo ^ ^ f^ ^ H N ^ ^ cIl N O ln ^ σι ^ ^ o ■q^, m ^ ^ co o H ^ H m σl <ιf tη ι ^ H W 03 n o n ^^ Ol ^ oo "^ o^ co to m f ^o n ctl σ^ o ιn "tf co ιn ιn ^ 't_f CD r-- ι ι r-- CD ι cD i^ ι^ r-~ r-- D CD ιn r~ σ> ι^ r~ ι^ r~ ι r^ r^ c3^ o cn c3^ oo σ^ σ-ϊ ( ι c^ σ^ cn cn <^ tj^ <τι cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn c^

0l m m Λ o o o o o o o H H ri H ri H N ^ι t N N N t^ι c^ι ( M m n t _'» "J ^ "J ln ιn ln ln ln ln ln l a ^0 Φ ^cι ^!) ^fl ^ ^ ^ c- ^• ^ ^J* ^T* ^J* ^1* ^5* ^f ^3* ^3* ^J* ^^ ^3* ^3* ^ϊ *^f ^T ^^ ^^ ^3* ^ϊ* ^3* ^J' ^3* ^3* **_*!* *^* ^3^ ^3* ^1' ^^ ^y "^* *^ζj^ ^J* ^J* ^J ^3^ ^ϊ* ^3 ^3f ^^ ^3^ ^-P ^ϊ* ^J* ***!* ^st* ^3* ^I* *■_*!* ro oo co rn ro ro r ro ro ro oo oo n ro oo ro oo oo oo ro ro ro n oo ro ro ro c ro oo oo oo ro oo oo oo oo oo oo ro M co oo

Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q α Q Q Q Q Q Q Q Q Q Q D Q Q Q Q Q Q Q D D Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q

PS OS PS S OS OS PS OS OS OS OS co co co CO CO CO D D D D D D D tf tf tf tf tf X X X X z z z z z z z os o a os PS PS ω Cxl Cxl fa] Cxl Cxl X X X X X X X X Cx] ω [x] Cxl xl x] J a a a Hi a a i a πa co c c tf tf CJ O CJ CJ tf tfo c tfo c tfo c t_fo t_fo c t_fo c zo EH EH EH EH EH O U U U J HI a a πi J HI Hi tf tf tf tf co M H rl CM rl CM rl CM CN rl rl I a tf CQ CJ CJ CO CJ tf CO CJ Q Q tf O tf tf CQ CJ Q Q tf CQ O tf CQ CJ CJ Q O O O z o o o υ υ o z tfoo o υ co z υ o υ υ υ o o zυoυoz oυ o z υ o o o z o o z υ υ o o o z υ υ υ υ υ υ ln w ^ ω m o H N ⁽^ 'l^ l ω m m o H N P^ * ln ^ ^ α) tJ^ o H l (^l^ ^ ιn ^ ω ιIl O H N ιn ^■» ιn u ^ ∞ t!^ O H ( n lJ l ^£ι ^ oo c^) o o o o o H H H H H H H H H H ⁽\i N tvi N [\i ⁽ N N N N m n n tn n to ffl fl n n 'i^j '» ^ < f 'j 5f "i' ⁱ» » in in in in in i in in in in o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in Ln in in in in in in in in in in in

O

ln n co fn ιe ω ιn cn r^ ∞ c o θ rH CN θ >tf ^ o c CN r ro c ri 'r "tf in cθ ι^ co cn r-- ∞ c iΛ cθ r-- r^ ^ "tf "tf in ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn co cD VD c^ iH iH rl rH rl rH rH rl rH rl rl rH rH iH iH iH iH rl iH rH iH rH iH rH i-H rH rH rH i→ i→ rH rH rl iH rH rH rl i-H iH rl iH iH rH rl rl ω n fl in o oi tΛ r- fi oo H ^ , , O-. O N Ifl HJ I0 0100 0 'lf 0 01 H H ^ O H rι| IO iη θ lJi n t" r" N ι r' rl O « N ( M» r^> KHI^l M' M in r~ ri ri co T co ri in cn m ro cn ^r- cft H m o i v oi tη io o 'f H β 'r oo i^ io m m in H Oi n in ω ω in r- N H tη tη kO H σi in ω N i^ N O o cN rH rH o r- r~ m vD ri 'tf CO ^~ ' —ϊ (l m ^ Φ co ^- <!l Ol ι {^ι ^o (Jl o c^ H ^ to o^ n n f^ ln ()o ( 'l' Λ ^fi ln Λ ι ιc ^D ^ι p^ H O H o m t)o H co f -tf co cM CN ri cN ri rH CN O O cn co r- r^ r^ r^ cD in cD i— r^ oo oo oo 'tf in ro cM ri ri cM O O ri cM CM ri ri CM ro o cn cn co r- oo oo r- r-

CM CM CM CM CN CM CM CN CN CM CM CN CN rl rl rl rl rl rl rl rl rl en o cn o r- cn r^ "tf cn ui o iO M^ H dn in o r- oi oo r- oi Mn M oi N ^ co ti h t M O ij iO in m n o o i irKO H O o ^ in ri uo n oo ri r^ cn o ri ∞ n o o H ιo N ^ "τ (η ι£ι ιo ^ eo H H ri ιxι o^ H N l^^, ri ^ ιn (D f0 l "l' e ^o o H ^n n σl ^ (Jl t ri o c ^ι ι ol r~ n cM oo o ri o i co Λ r- in t in 'i' iB H iη 't m N O N 'T t'i N σi t^ in r- ω o oj W H r^ f in ia' Oi rO 'i' ω t^ tη H o ^ H fli o i^ i^ o

N H ri ri θ ( r θ ( t H (M θ θ o (Λ

Q Q Q Q Q Q P Q Q D D D Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q D Q Q Q Q Q Q Q Q

X X X X D D D D D D D D OS PS OS OS OS oS co co co co co co co co co co co co co co co co co co co co OS PS PS PS PS PS tf tf tf tf tf CM

►a Ha H ι- H tχi ω fai ω χi fai fai c-1 fal M M HI HI rl rl rl rl rl H rl rl rl fa] fa] fa] fal fa] ti π H3 i-a a PS a a a u o u u ia Hi ia Hi ia ia H Hi co co co co co co a a a a a a a a a a a O tf tf tf tf tf rl CM CM rl rl CM CM rl rl CM tf tf CO Q Q tf CQ CJ D Q fa] fa] tf CQ CJ Q Q Cx] fa] tf O CJ tf O tf CQ CJ Q

O z υ o o z o o υ o υ υ o z υ υ o υ o z υ υ υ υ z υ z υ o z o o o υ z o z o o z υ o o o o z υ υ υ o z o υ o υ ιn co r-~ oo cn o rH CM rθ 'tf 000 0 ' ^■ -' rl rrll rl rl rl rl rl rl rl rH

2222222222 OOOOOOOOOO tfH tfH tfH EtfH EtfH etfπ EtfH Htf EtfH tfH

Table !

ATOM 5115 CE2 TRP D 355 90. .483 9. 626 170. 055 1. 00 44. 27

ATOM 5116 CE3 TRP D 355 89. ,247 9. ,858 167. ,972 1. ,00 43. ,24

ATOM 5117 CDl TRP D 355 91. .439 7. ,619 169. ,815 1. ,00 44. ,23

ATOM 5118 NE1 TRP D 355 91. .300 8. ,704 170, .656 1. ,00 45. .49

ATOM 5119 CZ2 TRP D 355 90. .049 10. ,871 170, .505 1. .00 43. .28

ATOM 5120 CZ3 TRP D 355 88, .818 11. ,093 168. .423 1. .00 43. .34

ATOM 5121 CH2 TRP D 355 89, .221 11. .589 169, .679 1. .00 43. ,92

ATOM 5122 C TRP D 355 92. .887 5. .812 167, .178 1. .00 33. ,47

ATOM 5123 O TRP D 355 92. .590 4. .693 166, .765 1. .00 33. ,00

ATOM 5124 N LEU D 356 93. .908 6. .044 167, .998 1. .00 32. ,81

ATOM 5125 CA LEU D 356 94. .728 4. .955 168, ,515 1. .00 33. ,21

ATOM 5126 CB LEU D 356 96, .194 5. .347 168, .594 1. .00 34. ,73

ATOM 5127 CG LEU D 356 97. .143 4. .144 168, .566 1. .00 35. .38

ATOM 5128 CDl LEU D 356 98, .543 4. .609 168, ,923 1, .00 35. .96

ATOM 5129 CD2 LEU D 356 96, .680 3. .065 169. .521 1, .00 35. .85

ATOM 5130 C LEU D 356 94, .263 4, .609 169. .925 1, .00 33. .74

ATOM 5131 O LEU D 356 94, .379 5, .412 170. .847 1, ,00 32. .37

ATOM 5132 N THR D 357 93. ,735 3. .404 170. .081 1, .00 35. .42

ATOM 5133 CA THR D 357 93. ,265 2. .931 171. .375 1. .00 37. .14

ATOM 5134 CB THR D 357 91. ,875 2. .264 171. .250 1. .00 37. .60

ATOM 5135 OG1 THR D 357 90. ,965 3. .173 170. .610 1, .00 36. .16

ATOM 5136 CG2 THR D 357 91. .342 1. .876 172. .632 1, .00 34, ,23

ATOM 5137 C THR D 357 94. .269 1. .898 171. .870 1, .00 37, .63

ATOM 5138 O THR D 357 94, .509 0. .900 171. .196 1, .00 38. .36

ATOM 5139 N VAL D 358 94, .857 2. .138 173. .039 1. .00 38. .60

ATOM 5140 CA VAL D 358 95, .849 1. .218 173, .602 1, .00 40, .52

ATOM 5141 CB VAL D 358 97, .132 1. .996 174, .025 1, .00 40, .83

ATOM 5142 CGI VAL D 358 98, .160 1. .048 174, .606 1, .00 40. .51

ATOM 5143 CG2 VAL D 358 97, .708 2, .739 172, .828 1, .00 39. .34

ATOM 5144 C VAL D 358 95, .308 0. .444 174, .814 1, .00 40. .94

ATOM 5145 O VAL D 358 94. .574 0, .998 175, .640 1, .00 40. .87

ATOM 5146 N LEU D 359 95, .673 -0, .834 174, .909 1. .00 40. .73

ATOM 5147 CA LEU D 359 95, .243 -1, .694 176. .015 1, .00 40. .07

ATOM 5148 CB LEU D 359 94. .083 -2, .584 175. .567 1. .00 37. .19

ATOM 5149 CG LEU D 359 92 .900 -1, .926 174, .858 1, .00 37. .09

ATOM 5150 CDl LEU D 359 91. .866 -2. .983 174, .499 1, .00 34. .94

ATOM 5151 CD2 LEU D 359 92, .291 -0, .851 175, .739 1, .00 36. .94

ATOM 5152 C LEU D 359 96. .405 -2. .583 176, .490 1. .00 41. .50

ATOM 5153 O LEU D 359 96. .472 -2. .906 177, .705 1, .00 43. .25

Fable 1

HETATM 5154 S S04 1 101. ,860 26. ,306 120. ,782 1. ,00 67.75

HE T ATM 5155 01 S04 1 101. ,069 25. .832 121. ,933 1. .00 68.48

HETATM 5156 02 S04 1 101. ,467 25. .556 119. ,574 1, .00 67.57

HETATM 5157 03 S04 1 101. ,618 27, ,745 120. ,575 1. .00 69.30

HETATM 5158 04 S04 1 103. ,293 26, ,096 121. .052 1, .00 68.39

HETATM 5159 S S04 2 112. ,071 33, ,384 123. .815 1. .00 66.75

HETATM 5160 01 S04 2 113. ,069 34, ,455 123. .623 1. .00 67.50

HETATM 5161 02 S04 2 112, .663 32. .092 123. .418 1. .00 66.52

HETATM 5162 03 S04 2 111, .676 33, .341 125, .238 1. .00 65.71

HETATM 5163 04 S04 2 110, ,883 33, .652 122. .975 1. .00 66.55

HETATM 5164 S S04 3 77. ,189 23. .441 106. ,691 1. .00 83.31

HETATM 5165 01 S04 3 78. ,088 22, .827 105. .694 1. .00 84.63

HETATM 5166 02 S04 3 77, ,908 23, .560 107. .969 1. .00 84.80

HETATM 5167 03 S04 3 76, ,762 24, .778 106. .237 1, .00 82.90

HETATM 5168 04 S04 3 76, ,003 22. .590 106. .876 1. .00 83.82

HETATM 5169 S S04 4 85, ,406 27, .736 115. .455 •1. .00 90.59

HETATM 5170 01 S04 4 86, ,326 28, .866 115. .704 1. .00 89.09

HETATM 5171 02 S04 4 86, .162 26 .578 114, .945 1 .00 89.08

HETATM 5172 03 S04 4 84, .725 27 .358 116, .711 1 .00 89.23

HETATM 5173 04 S04 4 84, .404 28 .146 114, .455 1 .00 89.64

iD 'j' 'tf CD D t~ r( Dc ιn coHl ωa o H rl CN rl iHCM rOCM CM CM iH 'tf CNCO rO 'tf -tf '^ 'tf -tf '^OO 'tf inCO 'tf rO 'tf inrO rO 'tf OO 'tf rl rHrl iHOOCniH OO O O^ σl lO ^ CN CN rO

co co oo oo oo oo oo oo oo oo oo oo oo oo oo cn cn cn cn cn cn o o o o O rH ri ri CM CM CN CM CM CM CM CM CM C r rO eO 00 rO CO 0 "tf j' ^j* ^5^ ^j* ^1'

9 rl rl rH i-H rl rl i-H i-H rH rl

© l-H oS os a oS α oS c^ a a oS oS oS co co co co co co co co co co co co co co o o o o o O O co co co co co co ω co co D D D D D D D D D D D D D D fa x x x x x x x x x x x x x x x x x x x x x x x x x x a a a a a a a x x x x x x x x x fai c^χ] fai c-] c-] fa] c^χi c^χi cχi fa] fa] fa] cχi c-]

H EH B H h H H B H H H EH a ι ι a Hi a Hi Hi J ιa Hi a ι ι & ftι αι iH ft o₎ ⁽-ι α ιa a Hi a ka Hi Hi α j ιa a H5 Hi a Hi Hi ι Hi Hi Hi ιa ιa ϋ rl rl CM CM rl CM rH CN co cj α fai α cxi tsi a tf tf CQ O Q fa] L I tf Q α tf co cj tf CO Q fa] O tf CQ CJ Q D tf CQ CJ Q Q O O O O O O O O O Z O O O O O z o o z o o o o z o o o o o o z o o o o o z uozoooooo z o o υ o o oo rH se

22222222222222222222222222222222222222222222222222222222

© oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H EH H H H H H H H EH EH EH H H EH EH EH EH EH EH EH EH EH EH EH EH EH H H H EH EH EH H EH -H EH EH EH H EH H EH EH EH H EH EH H EH EH EH EH EH EH EH o tftf tftf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tftf tf tf tf tftf tf tftf tftf tftf tftf tftf tf tf tf

Table 2

ATOM 57 C LEU 14 -4. ,532 65. 578 6.382 1.00 24. 80

ATOM 58 0 LEU 14 -5. ,057 66. 414 5.650 1.00 29. 43

ATOM 59 N TYR 15 -3. ,383 65. 778 7.011 1.00 20. 82

ATOM 60 CA TYR 15 -2. ,610 66. 994 6.900 1.00 16. 34

ATOM 61 CB TYR 15 -1. ,619 67. 035 8.076 1.00 16. 55

ATOM 62 CG TYR 15 -0. ,514 68. ,069 7.993 1.00 15. 27

ATOM 63 CDl TYR 15 0. ,667 67. ,811 7.296 1.00 11. 64

ATOM 64 CE1 TYR 15 1. ,680 68. ,768 7.213 1.00 12. 97

ATOM 65 CD2 TYR 15 -0. ,656 69. ,314 8.610 1.00 18. 36

ATOM 66 CE2 TYR 15 0. ,351 70. 281 8.538 1.00 17. 26

ATOM 67 CZ TYR 15 1. .513 70. ,005 7.838 1.00 16. 66

ATOM 68 OH TYR 15 2. ,497 70. ,973 7.754 1.00 17. 84

ATOM 69 C TYR 15 , -1. ,886 66. .980 5.571 1.00 16. 68

ATOM 70 O TYR 15 -1. .275 65. .984 5.215 1.00 16. 87

ATOM 71 N CYS 16 -1. ,970 68, .074 4.824 1.00 17. ,57

ATOM 72 CA CYS 16 -1. .277 68, .158 3.546 1.00 21. .60

ATOM 73 CB CYS 16 -2. ,156 68, .814 2.491 1.00 21. .60

ATOM 74 SG CYS 16 -1, ,350 68, .884 0.878 1.00 24. ,76

ATOM 75 C CYS 16 -0. .019 68, .991 3.739 1.00 24, ,96

ATOM 76 O CYS 16 -0. .082 70, ,116 4.239 1.00 24. .56

ATOM 77 N SER 17 1. .121 68, ,454 3.318 1.00 27. .88

ATOM 78 CA SER 17 2, .396 69. ,146 3.507 1.00 32. .13

ATOM 79 CB SER 17 3. .537 68. ,134 3.420 1.00 31. .38

ATOM 80 OG SER 17 3. .423 67. .359 2.243 1.00 37. .53

ATOM 81 C SER 17 2. .697 70. .337 2.596 1.00 33. .49

ATOM 82 O SER 17 3. .683 71. .055 2.805 1.00 34. ,92

ATOM 83 N ASN 18 1, .847 70, .563 1.601 1.00 34. .25

ATOM 84 CA ASN 18 2. .057 71, .665 0.670 1.00 33. .45

ATOM 85 CB ASN 18 1. .176 71. .458 -0.564 1.00 35. .74

ATOM 86 CG ASN 18 1. .612 72. .304 -1.742 1.00 37. .98

ATOM 87 OD1 ASN 18 2. .767 72. .247 -2.175 1.00 39. .41

ATOM 88 ND2 ASN 18 0. .685 73, .092 -2.273 1.00 39. .81

ATOM 89 C ASN 18 1. .814 73. .057 1.285 1.00 31. .98

ATOM 90 O ASN 18 2. .399 74. .035 0.843 1.00 34. .60

ATOM 91 N GLY 19 0. .971 73. .150 2.306 1.00 29, .15

ATOM 92 CA GLY 19 0, .714 74. .441 2.921 1.00 25, .91

ATOM 93 C GLY 19 0, .290 74. .337 4.375 1.00 24, .97

ATOM 94 O GLY 19 -0, .056 75. .331 5.025 1.00 20, .29

ATOM 95 N GLY 20 0. .314 73. .113 4.886 1.00 26, .22

ATOM 96 CA GLY 20 -0, ,066 72. .881 6.264 1.00 28, .13

ATOM 97 C GLY 20 -1. .565 72. .825 6.474 1.00 29, .03

ATOM 98 O GLY 20 -2. .030 72. .932 7.614 1.00 30, .16

ATOM 99 N HIS 21 -2. .320 72. .643 5.388 1.00 28, .28

ATOM 100 CA HIS 21 -3. .783 72. .580 5.463 1.00 26, .97

ATOM 101 CB HIS 21 -4. .428 73. .093 4.167 1.00 26, .00

ATOM 102 CG HIS 21 -4. .145 74, .534 3.875 1.00 27 .23

ATOM 103 CD2 HIS 21 -4, .774 75, .664 4.281 1.00 26 .36

ATOM 104 ND1 HIS 21 -3, .095 74, .941 3.080 1.00 24 .16

ATOM 105 CE1 HIS 21 -3, .090 76, .261 3.005 1.00 26 .23

ATOM 106 NE2 HIS 21 -4, .098 76, .724 3.725 1.00 28 .72

ATOM 107 C HIS 21 -4, .326 71, .188 5.740 1.00 26 .11

ATOM 108 O HIS 21 -3, .840 70, .195 5.198 1.00 25 .92

ATOM 109 N PHE 22 -5, .343 71, .130 6.592 1.00 26, .87

ATOM 110 CA PHE 22 -5, .998 69, .872 6.934 1.00 26, .99

ATOM 111 CB PHE 22 -6, .611 69, .925 8.339 1.00 27, .89

ATOM 112 CG PHE 22 -5, .597 70, .021 9.441 1.00 34, .47

ATOM 113 CDl PHE 22 -5, .700 69, .214 10.567 1.00 35, .19

ATOM 114 CD2 PHE 22 -4, .530 70, .917 9.353 1.00 37, .94

ATOM 115 CE1 PHE 22 -4, .764 69, .296 11.582 1.00 35. .09

ATOM 116 CE2 PHE 22 -3, .590 71, .005 10.366 1.00 36, .95

ATOM 117 CZ PHE 22 -3 .708 70 .191 11.482 1.00 36 .26 ιn CN CN CM CM CN CM CM CM CM CM CM CM CM CM CM CM ooooo OOOOOOOOOOOOOOOO O_{O O O}O OOOOOOOOOOOOOOOO

ιn c c_N oθ!H ι-Hr cN in "tf r--- θ _'^ c ιn t~ c ιH r c co ι "tf cn o cN θ ιn cN oo cn ι^

■tf i r- io ro oo r_^ o in (^ D in cD CN t^ t^ o co 'tf ^ cN rH Oi oovDr~ O M O r-- i [~ coo i O '^ ^ cD ι 'tf rHr~ ι ^ o r oo ri ^ c 'tf co co ricD θ o co e r-- ιncn 'r rico rθ rH inc -^ ι^ ι o cD ιn o cocn c cD ri ^ c ooo oo> )CD _l~ ιnoθ ι~ c cn θ rHCM c ιn ιn iD w m oo oo cD Dιn 'tf i-noo θ rH CNr "tf r o o θ rH θ θ ιH θ c ι-H rt c C^ ιo r~ cD coιocDCD D cD co D i" r-- ι^ r~ ι^ ι^ r-- r- cD iocD < ι co cDCDio ιocD r~ r- ι^

C CN C r c r e oo oO 'tf 'tf -tf ^ '^ ' ^ ^ 'tf 'tf '^ t in in in i i in i co ua io co cD o

CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CN CM CM CM CM CM CM CN CM CM C^

fal fal D O D D D D O D O O O O O O O O O Cxl Cxl C-l fal bl fal bl fal O D D D D D D D O O O O O O O CM C CM a fa]ia fc]fa] «3kicdcj a a tι a aos p ύ a o H H Hj Ha H ι- j cxiC HaH HaHaH H H H tf tf tf tf tf tf tf tf tf tf tf i i Ha H H H Ha H Ha πac CM C-i c^ rl CN rl CM CM rl rl rl CM rl CM rl CM tf CQ CJ l Q tf cQ CJ Q Cxl co a a tf CQ CJ α tf CQ CJ Ω Q Q tf CQ O tf CQ CJ Q Q tf tf CQ CJ U υozoυυoυυozυooυzυzzυozoυoυυoozυυυυυoozυυυoυozυυυoooozυoozoooo oo ooori cNr "tf LncD r-- oo HHHHriHHHririH

22222222222 ooooooooooo EH EH H EH EH H EH EH H EH H tf tf tftf tf

oooooooooooo oooooooooooo rl rl rl rl rl rl rt rl rl rl rt rl rl rl rl rl rl rl cn

(Iι cN o

I ri i c CD O^ r- r^ in cD rH iH cn r^ cM cn o O 'tf rH i^ c cD cN 'r i^ oo i e i ri -tf ri c 'r in c co cM 'tf r^ r^ o ^ r~ CN Cθ 'tf cn r-- "tf i ro αo cN ro ιn r~ co ιn i "tf cy> o o co ∞ ro 'r c r^ c co in c^ i^ cM in c^ "tf rH iH i cD oo o co co oo r~ c o r~ r^ <x) i i -^ iD in co D oo cD «tf CD iH in !^ CN CM ^ o o o σι oo oo ι^ θ ιH ri cM ro r cN in rH θ CM CM ro ιn r "tf ^ ιn "tf t ι cD i-3 r~ r-- oo oo oo ιn ιn ι ι cD in ^ t^ [^ - co cD CD CD r~ ρ-- r-~ r~ r~ ι~ r^ t^ r-- r^ r~ r~ r-- r~ r~ r~ r-- ι^ ι^

O O iH iH iH iH iH rl rH CN CM CN CN CM CM CM CN CO rO rO rO 'tf ^ 'tf 'tf 'tf 'tf 'tf LO in in in in in in ro ro ro oo to ro ro oo oo co co oo co oo ro ro ro ro c oo co oo ro ro ro ro oo ro ro ro co ro o^

aaHai-aHaHai- H i-a foC -i MC Xxxxaaaaaaaooooooø aatf tf tf tf tf tf tf owwwwcoc wi- HaHiH a

EH EH > > > > > > > tf tf tf tf tf tf tf tf CJ CJ CJ CJ EH EH EH EH EH Eπ H tf tf tf tf tf tf tf tftf tf tftf tf tf % tf tf tf tf tf tf tf tf co co co rl CM rl CN rl CM rl CN rl CM tf a cj cj tf cQoαα tf tf cQcjcj tf co cj α cxi N a a tf CQ CJ Q Q υozυoooo zυoυooυozoυozooooo o z oυoozυzz υozoυυoouo tf cQcjQcdcoaa tf m υυυυzυzzoozυυ r--- co cn o rH CM o "tf in co r^ cD cn o rH CM rθ "tf cn cn cn θ O O O O O O O O O rt rl rl rH ιH rH ιH ιH ιH ιH CM CM CM CM CM CM CM CM CN C^ iH iH rH CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

2222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooo tf tf tf tf tf tf tf tf tftftf t_f tf tftftf tftf tftf tftftft_f tftf t_f t_ft_f t_f t_f t_f t_f t_ft_f t_f tf t_f tf tf t_f t_f tf

CM CM CM ooooooooooooooooooooo ooooooooooooooooooooo

■^ o c o r~ "tf oo c r_^ o co c m c r_^ c c r orθ ri ιn∞ _ι--- e_θιn c -^ r-- o oo ιo cn

"tf t^ oo co o i oo oor o H in ooooocN CN cη ocN cncocD r^ cori O i^ o '^ cor c _'tf ^ -W i^ inσj 'tf CD i^ r θ 'r r~ ι^ oθ i c 'r oo oo oD cn 'tf r~ ^co -tf o cθ "tf ιH ocn oo ι^ ι^ cN t-~ r~ ιH r* r~ CN D rH 'r ιn cD ιnιnro cM ιH θσvcn cMCM CM CMCθιH rH θ cn oooo oocn cn oo oo r~ cn cn cn co rH ri cnσι θri cN roro roroo cn ( COlnιntonN

>O rH CD 00 CD rl 'tf Cn ^ σi CM r~ l^ rH 00 CM CM CD 'tf in rl ιH l^ ιH O 00 <^ 00 CN ∞ CD 00 CN Cn cD r-~ 00 O CM CD 0^

U3 io o Lθ Lθ CD co ^ co cN in ι rH in cD ι tn θ ιH θ co cn cn o θ "tf in ι^ u ιo ιn ιo r cn \^

CO rH C CO OO rH rH aD rH in θO CD VD O VO rH rH CM Cn n ^ *O Cn ιn cn cθ OO ιn {η rH CO 'r C CO ιH O ι^ O σι CN rH l^

'tf

O CN CO H CN CM C O O OO CM "tf ιn r^ ιn CD ιn ιn ιn i^ OO I^ OO Cn r (^ CM rl O O O Cn ιH O CM CM CM CM CM "tf <M CN rl CN rl O ^ H d H H d d d d d d d d d d H d d H H H d d d d d d d d H d d I rt i-H rl rl rl rl rl rl rl rl rl rl rH rH i-H I d d d d d d d d d d d d d i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i

CO OO OO Cn cn cn cn uO OO Cn cn O O O O O rl rH rH H rl rl rl rl rH rl CM CM CM CM CN CM CN CM rO OO OO OO OO OO OO OO OO ^'"tf 'tf ^ι^,^''tf «tf mmmι mιnιnmι co c oococ r r r c^ O(^'^ _"tf _"tf 'r 'tf "tf ''r'tf 'i^, 'r_"tf ^'r'tf 'tf "tf ^"tf 'tf "tf ^,tf 'j^,'tf "tf 'r 'tf 'tf 'r 'r'tf "tf ^r

a a a cu CU C-H ^Qu CM C CM CM Z Z Z Z Z CO CO CO CO CO CO CO CO CO CO Z Z Z Z Z D D D D D D D D Z Z Z Z Z Z Z Z Z D wwt tnwt na iJJiaHHHHHHHH HH jaa HiauHtiww iiiwwaHiaa HiHiHiHiaia co co co tf tf tf tf tf tf tf tf oc^joooa a oo jOHaH HaH Ha Ha H i- jcjcj c c cjc Ha rrll C C CMMM C CNM rrll rrll CCNM C CMM rrll rrll r rll C CNM rrll C CNN rl CM tftf CCQQ CCJJ u^Q QQ oυozυooooυo tf CQ tf CQ CJ Q Q x] fa] tf C^Q CJ CJ Q tf CQ O Q bl fa] tf CQ CJ Q Q tf CQ O O fal fa] υooooυoz ouozoυυozoz υ ozυυυυoυozoυouozoozυoooυυozouυυozooz

O rH CN cO 'tf in co r- co cn o ri cM ro -^ LO CO r^ co c o ri c rO 'r i co r^ co cn o iH CN o '^ ^ ^•^ •tf ' '^ 'tf 'tf '^ -^ -^ in in in i in in i in Ln i co o cD Ω CD iO D io io D r^

CM CM CM CM CM CM CN CN CM CM CM CN CN CN CM CM CM CM CN CM CM CM CN CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

00 rH se rH 2222222222222222222222222222222222222222222222222222222222222 o o HoEHoHoE^HoE^HoHoE^HoHoHoHoEHoHoEHoHoHoHoHoHoHoHoEHoHoH EoHoEHoEHoH EoHoEHoEHoEHoHoEHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoEH O tf tf tftftftftf tftftf tf tf tftftf tf tftftf tf tf tf tf tf tf tf tf tf tf tf tf tftftf tftf tf tftf tf tftf tf tf tf tf tf tftf tf tf tf

rimιnromc oθ"tf LncNroι cDri cD_"tf θ_"tf VDr~CNoθricNooθrH-tf oooooooooooooooooooo oooooooooooooooooooo rl rl rl rl rl rl rl

CM CM ^ o cD D rH "tf r^ cM m c cM co cD ι ιn co cD o r~ o o o o oι cD r^ ιή θ ^ c in ( r~ r θ "tf 'tf θ r^ "tf σi '^ cn "^

O H lβ o co O N N ^ Φ (Λ J n tO ln l N ω O ln m ln ^ N d H H Ol ^ ιr N ^^ ^ o ^ι σι O l ^ tO l d O (I) Λ ■τ H N co ^ H α! N N^^,n σl oo i r in r oo r^ co cD io r^ cN 'r r in 'tf oo oo in in σ^ rO H r i iD i i cN iD H Csi iD iH in r co o t i in oo o oo r^ cD CD m cD m cD r~- ιn m m co -tf r 'r ro r cN r rH θ θ ri o o o o O O rl CM O O O O O O o O O O o cMrθ_"tf -tf inooo

I I I I I I I I I I I I I I I I I I

■t_f <N rH rθ rH c c θ cn oo ι^ ro ro ∞ OT Cθ c ∞ rθ [^ co ι o co ro co «tf rH θ ∞ Ln ιθ ιH a ιn r-- c c <N θθ o r cN CM H ∞ ' θ H rH r^ ι- c 'r co - "tf CN ∞ r cD io ιn ι^ c o r ιn cM "tf cn oD "tf r ιn iD CM 'r io r^ r~ a^ o cM c cM io r "tf ^ oo o c r-- r^ o ιn "tf f^ ι σ^ c cn o c H H CM co ∞ ιn co r-- oo r- 'r ro ro cM CN cθ rH CM θ cn oo co r- cn cD CD co r-- ∞ cΩ cθ Lθ un ι ι co r^ ιn ι 'i^, "tf r vD r-- r-- c o H c o o cn cD o co rH θ CM r cM i "tf "tf ^r Lθ ι ι u ι Lθ Lπ Ln L ι Lθ i m ι "tf "tf 'tf 'tf "tf 'tf '3^ι 'j' ^,,tf "tf "tf ^,,tf -t^ι 'jⁱ 'r 'tf T 'tf 'tf -tf 'tf 'tf 'tf -tf ^r 'tf 'tf m i 'tf m in 'tf ^' ^r ^r in in in m m m i m in LO

^fi (η ^ (»ιo d co o m ιn o o ^ ln ι ιD m o d co o ιn <s ι^ o ^^ cι ol ln ω o^ ιn ^ co "^ n ^ ^ N ι o^ 'ϊ ιn <* t d l ^ ^ (^»l "l' ^D O (^ o H ^ ^ o w o ^D o m ^ σl H ^ι o ^ σl O ιn o ^ ^ ^ o ιo d ^ l n H d tι ιD σι M ^ ^ d ^ ^ ι^,l o <!l (^l co o ln ι^l '!^ ιn o3 <Jl "f (η o ι ιn o o m (Jl p^ oo co o oD CJ cD d ⁽η H H ln o ιn o n "» N ^ w m "I H (^ι ^fl ^ co n (^l ι H ^ι n^ ^o ^ σ^ ^ o ιc⁾ D cl H H "» ιn o o ω t π w ^n "l' ^D Ol d ^D l o σl ^ l o o o

O Cn OO OO r~ rl rH rt CN r "tf rl O Cn rl CM CM 0000 "tf in CD CD CN 00 o θ ιH co oo oo co ιn 'tf CD co cD ιn ιn co ιn r-- oo cn oo oo o co cn cn cn o co r-- oo ri d I I I I d d d d d d d rH I rl rl i-H rl rl rl rl rl rl rl rl rl rl rl l l l l l l l l l l l l l l l l l l rl l l l l rt l l l rl I I I I I I I I I I I I I I I I I I I I I I I I I I I I

co ιo co co co ιo co r-- r "J '* ι

D D D D D D D a a a a tf tf tf tf tf D D Ω D n D D D D a a a a a ι^ ι- ι- ι-a ι- ι- ι- x o fa3 fa] fa] fa] fa] fa^] fa] fa^] fa^] bi fa] fa] fa] Ha iJ Ha iJ Ha H Ha H H H H Ha Ha H x] fai fa: ti fai fa] tf tf tf tf tf tf tf Ha Ha Ha Ha i-a H Ha ι- H Ha H H co co c c c co tf tf tf tf tf o o o o o o co o co c co c > > > > > > > o o o o j j c c cj o > > > > > > > H rl CM rt CM rl CM tf a o Q α tf a c tf m tf cQc αui cxi tf m t tf a CJ cj tf tf a cj Q J ti tf a cj CJ o o υ o o υ o z o o o o o z o o o o z ooo ooooz o oo oo z o o o o o o z o υ o z o oo oo ooo z o υ o o o o z rH CN Cθ 'tf in co r--- co cn o ri cN ro ^ ιn co r^ co cn θ rH CN cθ 'r ιn co r^ ro cn θ ri cN rθ 'r ιn co r^ o o o o o o o o o d d d d d H d d d ^{( (}\i ⁽\i ^{( ( (}si N N M N m r ⁽^ n r tη M ι tη ⁽η ιi' ^ ^>» ^ ^ιj ^ ^ ^ ^ f in ιn ιn ιn ιn ι ιn ιn ιn ιn ιo 'a oo oo n oo ro ro ro oo oo oo oo oo oo oo oo oo oo oo n oo n ro ro oo oo oo oo ro ro ro n oo oo ro ro r ro ro m

00 rH se 2222222222222222222222222222222222222222222222222222222222222 rH o o oo oo o o o o oo o o oo o o o o o oo o o o ooooo ooo ooo oooo o oo o o ooo o ooo o o o o o oo o © ti h tH tH EH tH H h H H H H H H EH H H ti H tH tH H H tH H fH H tH tH tH H B H tH H B ti EH tH tH tH B H tH B H h Ei h H H tH EH H B tH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

T t-- O r^ in <T_l OO CN r r-- CD Cn rH CO OO _OO ^ O O CO -_C ^, ιn "t_f r~ CN O rH CN Cn ri σι σ^ O OO CN rH O O ιH CD OO lO 'tf OO CD σi rH CO

't_f σ_\ crι oo r o co c rH in cD oo ι-H σ^ cM cn ^ cM i cN CM in c c ιθ 'tf r Λ o σι r σι c ιH in c^ c3o o ^,^ r^

IN "S o r~ rH θ σ^ cM r ri cn ιn ri cM θ co θ ιn r-- o eo cM CD co oo ro D CD CD "t_f r~ r~ oo ^ σ^ oo rH CM in o σ^ o oo rH θ cM ^ D

CN CM OO rO CM OO OO OO CM CM CM CN eN rl CM rH rl CM CM Ovl CM CM CM OO OO OO CM CM CM CM CM CM CN CM rO rO OO 'tf OO rO rM rO C r^

CΛ oooooooooooooooooooooooooooooooooooooooooooooooooooσooooooooo oooooooooooooooooooooooooooooooooooooooooooooooσooooooooooooo d _d d d _d d d H d d d d ri d d d d d d H d H H H d d d d H d dd d d d d H d d d d d d d d d d H H d d d H H d d HH d d d csj ^ σ^ ^ r ^ CN

^ ri r^ r^ ιH D oo ιθ ιH θ rH ιH rθ "tf d o ln "f ιn o co ιn <tf C 'tf ro cvi ri cN ιH CD in r-- oo oo o oo cn cn o cn o cn co oo t--~ cD rH θ CM r "tf in cM ιH CM CN ri oo o cN CM ι ιn ιn ιn ι ιn ιn ιn ιn Ln ιn ιn ιn ιn o ι ) i ιn cD ιn cD in ι ιn Ln ιn D D iD D io D io o D CD iΛ iD iΛ CD cD c^ 0 (^,l O l (o o cΛ '3'

(η "f ιn ιn Φ ιn ω ιo c^■ H t N H H o m (η ^ ^ ι ιD ^ oo co o ι ιn ^o ^-l w ^ ^ ω ^ Φ ιn ln ω cn co t3l co m σι co o o H O H H O O H ( O ri O H

ι ι ιn ι ιnιn ι ι ιn ιnιncoiDioιo o <o ιoco r"~ r- r~ ι^ r~ [~ r~ r~ r^ ∞ ∞ ininin ininin ininininin inin inin in in in in in in in inin in in inin in inin inin in inin in in in Ln in co co io c^

a a a a a a a a os cxi i xi J -i -i fai fai o co c co co o c o o a a a a a a a a a a j a D D D D D D D D D a a a o a a a x x x x x x x x x x x x x Ha H Ha Ha Ha H i-a H x x x x x x x x fai fai fai ci fai fai a a a H Ha HJ H i-a H H Ha H a a H H Ha H rl rl CM CM CM rl rl rl CM rl CN rl CM tf mcjQC-iQCxiisia tf cqc cjα tf cocjαcjco tf CQ cj tfυ CυQ CoJ CυJυoz tfυCυQ O f oυυυυυυυooozυυυυυooz υυυυυzυozoυoυo oQυaol fao]uoz tfυυO CoJ CυJυoz tfυυo

CD ro

co cD io oo c^ 'tf oo o oo r~ ^ ^ι ffloolH OlOON HlBH CM CMCM CM n r rO r rO0 ooooooooooooo ooooooooooooo

ⁱ£>ιoco ιocococΩco co^tocoιnιnιnιn ιnιnιnιn ιoιo ιo co ιo c^{Q i} ιo ιo ιocDco c ιoco ^<

CMi ι ro o ^ co o c»i£)CNCN ^ro r^ r--- ιH c3oooor-- r-- _"tf D

0(3lm OO O [D

CM rH rl CM CM CM CN iH

I I I I I I I I

ro r co r ro r M ro 'tf ^«tf -^ ^ 'tf ^ ^ "tf «tf ^ ^ ^ ι ιn ιn ιn ιn ιn ιn ιn cD CD CD cD CD r-- r^ r^ r^ r^ r^

IO CD CD CD CO CO CD IO CD CD CO CO CD CD ID CD CD CD CD ID IJ CO IO CD CD O CD CD CD CO CD CD ID IO CD CO CD CD <J31D IO CD IO

z z z z z z z z a a a a a a a a a a a D O D D o o D D tf tf tf tf EH H EH EH EH H EH EH CM a c a c-i CM αi a a a a a a a a -i C-i a r ι- Ha Ha Ha H ι- H H x x x x x x x x fai t] c-] iχi fa] Cχi cχi fa] Ha ι- Ha >J C^χ] ] fa] fa] ^[χ] C^χ] c-^] fa^] co co co co co co co co a a a a a a a co co co co c cj cj jcj c o j cj EH EH EH EH EH EH EH EH H H EH EH Ha Ha H Ha Ha i- H H tf tf tf tf 22222222 tf tf tf tf tf tf tf tf EH EH EH EH EH EH H tf tf tf tf rl CM rl rl CM CN rl CN rl CM rl CM tf a o Q co fa] tf acjocxiα iNi tf to o α α tf to tf CO CJ Q fa] tf CQ CJ Q Q tf CQ CJ CJ tf CQ CJ z o υ o o o z υo zo oυo o o oo o υ o z oυoυoooz oooo υ o υ co υ υ O Z υ υ υ o o υ o oυoυυozυoo r ' incor~ ∞ c θri cMo "tf i o r-- ∞cno ιH C cM CNCN CM CN CN CNOooorocoeooooooorooO 'tf ' 'tf oo se i-H 2222222222222222222222222222222222222222222222222222222222222 rH ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo © H H H H H EH H H H EH H H H H H H H H H H H H H EH H EH H H H EH EH H H EH EH EH -H EH H EH H EH EH H EH EH EH EH EH EH EH H EH EH H H H EH EH EH EH tftftftftftftftftftftftftftftftftftftftftftftf tftftftf tftf tftf tftftftftftftftftftftftf

O

Tf

Tf r-. _rH «_tf r~ oocD cn iH<o oooo 'tf CM r~ oor oo r~ coc r~ CD Co iH r-- in o iH ^ ro <^ cD <Ti r~ r~ r^ ιn cn co cN Lθ ιn co co r~ !-H θ _"tf CM in o o c~ cn ιo ιn co cn cM CN cn cn cn cn cD in roc^

IN

O cM -_{tf C}o r~ r-- r cn Dooo oooo o oo σ r_^ r~ co ι_^ r~ r~ p~ ιn ιn rH coι^co ιn cM in -^ cD ι-HC^ o in in OO OO OO rO CM CM CM CM CM Cvl OO CM CN CM CM CM CM CM CM CM CM CM CM rH iH rH i-H rl rH rH i-H CM rl iH rH CM CM CM CM CM C^

CΛ oooooooooooooooooooooooooooooooo ooooooooooooooo O.O_O_O_O_O_O_ O_O_OOOOO

H oooooooooooooooooooooooooooooooo oooooooooooo ooooooooooooooooo rl rl rl rl rl rl rl rH rl rl rl rl rl rl rl rl rl ft. ιn ιn ΦO rlo O O rl CM O rl i i t i i i

o r oooo CD oθ ιH in ιncn<^ ιH CM θθco co θ ιH oθ ιH oo cMco cM cn cM rH CM CM co co o r~ ocD ιnoo oo cN θιn oo rooo cDooιncD oo ∞ r rH c io i co 'r r^ cocncn _'tf co 'rco o o in oo r^ o αD∞ 'tf ri iH co α 'tf rH ro cn r o r^

∞ i r^ r~ oocDoocoo roo oo r~ "tf σι cn ro r~ ocN θ C θ o σι CN rHin r~ rH co ιH ro r~ r~ 'rcDCM 'tf CN in c^ ι ιn ιH θ ri oo <^cM CMroc r ιH C ro c CM rio n o ^ 'r "tf CD r-- r~ oo c cD r~ cooo co D r^ oo cn oc o θ ιH ιH ι^

C

o o o θ ιH rH ιH ri cNCN CNC C CM CN CN ro r oo ro o o rθ"tf 'r ^ 'r ^ "tf ^ "tf "tf 'tf 'r "tf in ι ι ι^

cc^Qj M -ixxxxD-DDDDDDDDDDDDDDDaaaaaaaaaaaaxx xaaaaaazzzzzzzzz aaaaa cocococθHiHaHaHafa]fa]fa]fa]af]fa]Cχi ofa] i χicicχi faifaixxxxxxxxx H H ιjHifa]fa]fa]fa]fa]fa]HaHaιJι^H^

^<< (3θθoaajaaaaaaaaaa₁ijιihHtHEHEHHHHHHE<Bt3t5θunnmMM(n Uuuu )uuuHEiHtHEHtH rl CM rl CM rl CM rl rl CM CM rl CM rl CM

Q Q tf tf m O Q Q tf CQ CJ Q Q tf CQ O Ω fal Q fal co a tf tf CQ CJ tf CQ O Q fa] fa] tf CQ CJ CJ ooυozυυozooυυυυozυυυoooozoooooooυooozυoozooooozυυoυozυozυooυυ

>tf

CD CM roro

"tf

00

2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH H H EH EH tH EH EH EH EH EH EH EH H EH H EH EH EH EH EH EH EH EH EH EH EH EH EH EH E^H E^H EH EH EH EH EH EH EH EH EH H EH EH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

oooooooooooo oooooooooooo rl o t^ <τι oo o cD ri r^ ιn ∞ _ιH θo oo ∞

H r- m t t o w Λ tn H ON

CM θ θ _ri o o c r r "t_f i ιn ιn cD ιn 't_f CD r_^ oo o o o o r^ r~ r^ r~ r^ c3^ σ^ cn rH in ιn 'tf tη cM CM r < co o ^

I I I I I I I 1 I I I I I I I I I I rH < — I r-i I I I I I I I I <-H I 1 I I 1 I 1 I I 1 I I I I I I I I I I I I I I I I I I I

I I I I oo "I OO t^ ιn (D n Φ ^ m ιD lD HJ ■ϊ ιn o o ^ ^ n o ω oo H ^ ω ^ H σl H H ιη M lo O ln o * d ^ N H ^ ι' ^O H d oo ^ n « o ol ( ιn ΛW (l) ιn

O CN CO l^ Cn ro ∞ lO CO CO rO OO rH O 'tf O CO iH ∞ iH CN CM CN CD lO CN W CN CN CM CD CN OO VO 'tf -O CN C

• Co r-- o c <t_f 'r cn _Lθ o cn ro cN r^ cn o ' C co cM in _ιH cn ιn "t_f r~ cn _ιH cn cM H o oo co ιn co ^ "tf in 'tf in ιn ι r-~ ra r^ 'tf in "tf '3^, θ "tf in co ιn ιn ιn cD r^ c oo θ ri o oo c r~ r^ r~ oo co r~ in in in in in in Ln in in in in in in in in in in in in in in LO in in in in in in in cD co co in in in in in in in in in in in in in in ^ cn cn cn "tf in θ rH r-- cn cN θ CN oo ro r-- cn "tf in rH co co o r~ co ιn co co cn !H ιH cn cN ro [--- r^

(^ι ^ n M ι ^ o o ^ ι O "J O ^ m o N » "t^, ^f d 't^ι o c W O ι ^ rn ^ ιn w ^ ^ co ^l d o α) d π ιfl (^»l t v (lo <^' tD ιn r- <Jl r ^ ιn to ^ o o r- ι o r σv CN i cD in ιn -tf θ r^ oo ιH ιH ιH oo θ "tf in co ιn σ^ r~ ιn α3 o 'tf θ <rι c in ιn ιH C r-- σι c r^ ιH ri cM θ cn ιH θ ri cn cn o o o cD θo r^ oo cD i~ oo oo c r~ ιn '^ cD ι co r~ r~ oo o ιn 'r uo ιn co r~ ro o o cN CM ro ^

N N N N H N M N d d N N N d d H d d d d d d d H d d d d d d H H d d d d d H d d d d d d d d d d d l I I I rl l rl rl l I I I C

I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

03σiΛmmffi(jι0\oooooooo HHHdd dd( ΛiNN( ( M< < nnnnnn-»"»"<'"i^,^v^^ιnΛi ιnιnιnιnιnιnuiι iflw ι^t^^~r~^ ^^∞ω∞ωωαoωω∞ ωωcoωraooω∞mωooιI)ωooωraωω∞ωooωωωωωωωωm∞ro∞rotDωoorooo∞raα]co

a θ O O O O O O Z Z Z Z Z Z Z Z D D D P D D D D D D D D D D D D D D W C0 C0 C0 C0 C0 D D D D D D D D Ca fa] fa] fa] fa] fa] Iχ] [χ] [-] Cχ] [χl D D a a a a « a c co o co co OT w ω H iH H Hi ri Ha Ha ι-a H Ha ι-a ι-a ι- iH Ha H H ι-a x x x x x i i cd H Oi M M C a a tf tf tf tf tf tf tf tf o o o o o o o o o o o o H Ha Ha Ha H Ha Hi H HM CM ij C rl CM rl CM rl CM rl CM rl CM rl CM

Ωtf mcj tf cαc αα tf m O Ω Cxl Cxl tf CQ CJ D fal fa] tf CQ CJ tf CQ CJ Ω Ω tf CQ CJ Ω Ω txl fal CO tf ozoooυυozυoυozoo υoυυooυozoυυυooυozυυcoυ ozoυυoooozoυoυoυυυυozo 'f ιn oo rH

2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

O H H EH H H H EH H EH EH H EH EH EH EH EH EH EH H EH H EH H H EH EH EH EH EH H EH EH EH EH EH EH H EH EH EH EH EH EH EH EH EH H H EH EH H EH H EH H EH H EH EH EH H o tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tftf tftftftftf tf tf tf tf tftf tf tf tftf tf tf tf tf tf tftf

ιocDθ

oooooooooooooooooo oooooooooooooooooo

M ro CM rl CM rl rl O O O O CO rO OO I I I ^ιn o^

co iD co ιo iΛ CD r- r--- r-~ r-- r~ r~ r-- r~ r-- oo ∞ ro ∞ ∞ co oo co oo o

CO ∞ ∞ ∞ ∞ OO CD ∞ OO OO OO OO CO OO OO OO OO OO ∞ ∞ OO CO ∞ ∞ OO OO ∞ ∞ OO OD OO OO OT CO OO CJO Cn C^

D D D D D D D D D D D D D D D O O O O O O D D D D D D O D D D D D D D D D D D D D D D D D D D Z Z Z Z Z Z Z Z CO w u w u u w a a a hi a a a a a ^aJ rtrt rt ai i-irt i-i rt tf w wH WM WM W ia a ij a a i a Hi J rl CM acjΩΩ tf moΩc-ifa] tf mcjΩfaacoaa tf cα ø Ω Ω tf cα cj Ω d di tf co CJ Ω cd fai tf CQ CJ Q Ω oooυoozυυoυooυozυoυυzυzzυozooυυυυozυυoυooυozυυυoooϋ I o z υ υ υ o z o o cD r~ oo cn θ ιH CN rθ "tf i co r~ c» c o rH CN rθ 'tf -θ co r~ oo cn θ !H CN c "tf

O O O O rl rl rH ιH rl rH ιH rH ιH rH CM CM CM CM CM CM CM CM CM CM rθ Oθ r r O CO CD CD CO CO CO CD CD CD CD ID CD <Λ VD CD CD IO CO CD CD ID CD CD CD CD CD CD CD CD

2o2o2oo22o2o2o2oo22o2o2o2o2o2o2o2o2o2o2oo22o tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

θ '^ "tf in r~ r^ cninco r^ cM in in 'tf o r^ 'tf ^ ιηωratιιoiHπ(ηιnωιn"P(ηιnιnιniDioιnw rl rl rH rH CM CM CN CM CM CM CM CM eN CM CM CN CN CN CM CN CM CM CM CM CM CN CN CN CN oooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooo rl rl rl rl rl

ooιH roo

(η

_CD co cn coo co r-~ cn Lθ in iD in

CD "tf CMCD o cn ρ-. r~ oo cnoo cno ιn ιn ιn «tf 'tf 'tf 'tf "tf coco cD CDcorθrHθ θ θθ ri o o o o oθ ri ri ri cM 'tf inm ι θ i* τ "tf 'j^, ' "tf _" 'tf "tf CM rl O CD CD OO OO OO OO

I I I I I I I I I I I I I I I I I I I I I I I I I

oo o ro r r oorθ 'tf -^ 'r 'tf 'r -^ ^ «tf -^ "tf 'j' "tf inLn ι ιn Ln ιnι ι cD D iovD iDCD D r-- r-_' r--- r-~ cncncncn cncncncncnencn cn cn cn cn cn cn cncn cn cncncncncn cn cncncncn cn cnc^

co co co co co co co co w a a c-i os a a a c-i a a a a z z z z z z z z a a a ps a a a a a a a a a a a a a a a cxi fai cxi cxi fai fai fai cxi a a a a a ri i M M H H M i x x x x x x x x x x c co co co co co co a a a x x x x x x x x x x x H H Ha Ha πa iJ Ha Hi ia fai fai ixi c-i a a εH EH H H H H H H H EH EH H tf tf tf tf tf tf tf tf H EH H EH H H EH H EH EH H EH EH H EH H EH EH EH H l H H H H rl c O C CO O rl rl CM CM CM rl rl tf cooΩcxi Ω xi oa tf mocj Ω tf m o o o z oυυoυooooυozoυoooυozυυoo HHHHHHHHtMclNC CMNCNN se rn 2222222222222222222222222222222222222222222222222222222222222 rH o EHoHoEHoEHoEHoHoEHoEHoHoEHoHoEHoEHoEHoEHoHoHoEHo&HoEHoEHoEHoHoHoEHoHoHoEHoHoEHoHoEHoHoHoHoEHoEHoEHoEHoEHoHoEHoEHoEHoHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoHoHoEHoH © tftf tftftftf tftf tf tftf tf tf tftf tftftf tftftftf tf tf tf tf tf tf tf tftf tftftftf tftf tf tftftftf tf tf

O

Table 2

ATOM 728 O SER 99 -7. 602 56. 432 -9. 084 1. 00 23. 70

ATOM 729 N LYS 100 -9. 101 55. 863 -7. 491 1. 00 27. 88

ATOM 730 CA LYS 100 -9. 195 54. 468 -7. 903 1. 00 27. 72

ATOM 731 CB LYS 100 10. 045 53. 687 -6. 897 1. 00 26. 37

ATOM 732 CG LYS 100 -9. 848 52. 176 -6. 908 1. 00 25. 42

ATOM 733 CD LYS 100 10. 364 51. 544 -8. 171 1. 00 23. 12

ATOM 734 CE LYS 100 10. 292 50. 028 -8. 091 1. 00 26. ,78

ATOM 735 NZ LYS 100 11. 136 49. 473 -6. 995 1. 00 27. 99

ATOM 736 C LYS 100 -9. 809 54. 391 -9. 293 1. 00 28. ,12

ATOM 737 O LYS 100 -9. ,402 53. 571 -10. 113 1. ,00 27. .55

ATOM 738 N LYS 101 10. ,777 55. 264 -9. 552 1. ,00 30. .25

ATOM 739 CA LYS 101 11. ,454 55. ,297 -10. 840 1. ,00 34. ,17

ATOM 740 CB LYS 101 12. 770 56. 070 -10. 720 1. ,00 36. ,86

ATOM 741 CG LYS 101 13. 554 56. ,186 -12. 025 1. ,00 37. ,77

ATOM 742 CD LYS 101 ^•14. ,802 57. .027 -11. ,843 1. ,00 38. .43

ATOM 743 CE LYS 101 15. ,534 57. .241 -13. ,161 1. ,00 39. .99

ATOM 744 NZ LYS 101 16. ,726 58, ,124 -12. 996 1. ,00 39. .40

ATOM 745 C LYS 101 10. ,604 55. ,923 -11. 943 1. ,00 34. .72

ATOM 746 O LYS 101 10. ,696 55. ,536 -13. 102 1. ,00 35. .47

ATOM 747 N HIS 102 -9. ,780 56. .895 -11. ,591 1. ,00 34. .55

ATOM 748 CA HIS 102 -8, .955 57. .543 -12. ,596 1. .00 36. .40

ATOM 749 CB HIS 102 -9. .241 59. .048 -12. ,584 1, ,00 40. .56

ATOM 750 CG HIS 102 10. ,628 59. .392 -13. ,040 1, .00 44. .63

ATOM 751 CD2 HIS 102 ^•11. ,758 59, .655 -12. ,340 1. .00 45. .60

ATOM 752 ND1 HIS 102 ^■10, ,983 59, .438 -14. .372 1, ,00 47. .62

ATOM 753 CE1 HIS 102 ^■12. .272 59. .715 -14. .472 1, .00 49. .39

ATOM 754 NE2 HIS 102 ^■12. .766 59. .851 -13. .253 1, .00 48. .16

ATOM 755 C HIS 102 -7. .471 57. .249 -12. .393 1, .00 35. ,09

ATOM 756 O HIS 102 -6. .604 58. .097 -12. ,635 1, .00 30. .28

ATOM 757 N ALA 103 -7. .198 56. .019 -11. .962 1, .00 35, .43

ATOM 758 CA ALA 103 -5, ,842 55. .561 -11. .705 1, .00 37, .35

ATOM 759 CB ALA 103 -5, .871 54. .138 -11. .211 1, .00 34. .67

ATOM 760 C ALA 103 -4. ,948 55. .666 -12. ,934 1. .00 39, .11

ATOM 761 O ALA 103 -3. ,886 56. .287 -12. .887 1, .00 41, .02

ATOM 762 N GLU 104 -5. .382 55, .046 -14. .025 1 .00 40 .77

ATOM 763 CA GLU 104 -4. .641 55, .059 -15, .282 1 .00 40 .86

ATOM 764 CB GLU 104 -5. .591 54, .695 -16. .422 1 .00 43 .20

ATOM 765 CG GLU 104 -5. .130 55, .168 -17. .787 1 .00 49 .96

ATOM 766 CD GLU 104 -6. .293 55, .507 -18. .713 1 .00 52, .78

ATOM 767 OEl GLU 104 -6. .045 56 .087 -19, .796 1 .00 52 .63

ATOM 768 OE2 GLU 104 -7, .453 55 .194 -18, .357 1 .00 53 .57

ATOM 769 C GLU 104 -3. .971 56, .408 -15, .569 1 .00 39 .23

ATOM 770 O GLU 104 -2. .804 56, .462 -15. .944 1 .00 38, .66

ATOM 771 N LYS 105 -4. .714 57, .493 -15. .390 1 .00 39, .54

ATOM 772 CA LYS 105 -4. .192 58 .833 -15 .641 1 .00 38 .83

ATOM 773 CB LYS 105 -5, .345 59 .814 -15, .842 1 .00 35 .41

ATOM 774 CG LYS 105 -6, .562 59 .186 -16, .484 1 .00 34 .90

ATOM 775 CD LYS 105 -7, .832 59 .953 -16, .147 1 .00 36 .61

ATOM 776 CE LYS 105 -9. .058 59 .174 -16. .584 1, .00 37 .07

ATOM 777 NZ LYS 105 -8. .974 57 .765 -16, .092 1 .00 38 .64

ATOM 778 C LYS 105 -3, .340 59 .314 -14 .473 1 .00 39 .73

ATOM 779 O LYS 105 -2, .691 60 .350 -14, .564 1 .00 42 .17

ATOM 780 N ASN 106 -3, .345 58 .568 -13, .375 1 .00 39 .76

ATOM 781 CA ASN 106 -2, .586 58 .962 -12, .194 1 .00 41 .17

ATOM 782 CB ASN 106 -1, .099 59 .080 -12 .538 1 .00 41 .89

ATOM 783 CG ASN 106 -0 .386 57 .741 -12 .474 1 .00 45 .65

ATOM 784 OD1 ASN 106 0, .626 57 .531 -13 .143 1 .00 48 .02

ATOM 785 ND2 ASN 106 -0, .908 56 .827 -11, .653 1 .00 44 .93

ATOM 786 C ASN 106 -3, .117 60 .279 -11 .625 1 .00 39 .74

ATOM 787 O ASN 106 -2, .413 61 .281 -11 .557 1 .00 39 .43

ATOM 788 N TRP 107 -4, .379 60 .254 -11 .222 1 .00 39 .27 n ιn cMc ∞

oooooooooooooooooooo oooooooooooooooooooo

co ιncn

O ri cN oo -tf CN oO 'tf LO cO 'j' cn oo co r- co r^ oo ^lO Cn cD 00 C0 lO in 'tf CN rl 00 r000 00 r0 00 00 rM CN O O ιH O CM CM CM r0 -=P in cD 0000 CM rl CM rl CN CN rH rl 00 O ddddddddddd I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

I I I I I I I I I I I

ιH in iniH oιn m co

I I

^^^^^^r-^^^^ι~^ωooc cotDO CococDωco IlcΛ(3l(^σlσισιoooo^-lHHrlHH

Ma HCMaaαH iia C a iCi dfaifaiωfaifaifaitacxifai i-aHaHaHai-aHaH xxx X O D D D D D D D CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO aa a a a aaaaa aa a aaaa aaa a aaa tf tf tf tf tf tf tf i-a πaπa Ha Cxl W Cxl Cxl fal Cxl fal Cxl X X X X X X X X X X X X X X X X X X

EH H H H EH H EH EH EH EH EH EH En a CU u C C-i CM C C M a C > > > > > > > CJ CJ Cj O Hi Ha πi HU j ia i Hi Ha i Hi i i Hi ia Hi ia h Hi ^ ia i i Hi Hi eH ffl O Q W W Q W N N S tf CQ CJ Ω Ω fal fal cO tf CQ CJ CJ tf tf CO CJ Ω Ω tf CQ CJ Ω Cxl CO tf CQ CJ Ω fa] CO υυooυoυzυυυυozυυoυoυυυυozooooυozυo O Z oυυυuooz υ υ o o υ z o o z υυυυυzυo

2222222222222222222222222 222222222222 O OOOOOOOOOOOOOOOOOO OOO OO O O OO OOO OOOOOO EH H H H EH EH EH EH EH EH EH EH EH H EH EH EH EH EH EH EH EH EH EH EH tf tf tf tf tf tf tftf tftf tf tftf tf tftf tf tftftf tf tftf tftf tf tftf tf tf tf tf tf tf tf tf tf

∞

oooooooooooooooooo oooooooooooooooooo ι "tf Cθ oo θ ιH ∞ ιH (~ 'r r~ ιn o<^ cM∞ rHCM cnoc" 'r σro ∞r~ o or^ co rooo r~ rH CM r c cn o cD o o ^ ιH ro cooo oo ι 'r 'r noo cnr~ CN cnr~ CM co "tf r--- cn o co CM θ θ ιH 'tf ooθ '_J" oo oo rH o rH θ rH in ιH r-- θ "tf 'tf θ Ln "tf "tf 'tf CM in ιn cM r_^ θ "tf CM Dc~ r 'tf ri θ ιH oo ιn < ι θ θ rH 'tf rH ro oo oo cN in oc "tf ^ o c CM roo oo o oθ ricM 'tf oθ 'r "tf o ιn cD ιn D iD r-~ r_^ oooo r~ r-- ooθ ri rH CMr «tf 'tf ^i' θθ o θ ri rl CM CN O0 "tf "tf 0 "tf CM CN CN CN "tf L l I I I I l l l l l l l l l l l l l l l l l l l l l l l l rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl

I I I I I I I I I I I I I I o σι o r^ ιn o oo roιθ ι θ 'τ oocN θ r~ CM CM rH CMin cri rH «tf CD oo θ "tf in ocDcM '-θ rH in riιnri (3 r~ r~ rH ri ro cD r^ oocM o rH r~ oe ro oo r~ oo oo θ rH t^ o ιn ro oo cM CDro ιn co oo ovD cocoιn r~ cD -w σι oo r~ co cM θ 'tf θ oo co oιn σ^ rH ∞ ιn ιn rH cn r~ co ιo ιθ "tf "tf ⁱ" ⁱώ r-- ∞∞ c cD ιnr--- ∞CM " ∞ ∞ θ ιH co i"CM r^

CM "tf ^ ιn 'r -tf in 'tf in cD r~ co r^ r~ oo r-- o oo ooo θ ι--- r~ r^ cD 'r r cM rH θ CD o r^ r^ [^ cn

ii 'tf ' 'r T 'tf ωcoωωooω ra c ωtΛffl tJiσi m σi Λ aifli tiiΛooooHHH ri ri riN t NC W N dd dddri iH rH rl rH iH rl rH rH iH rH iH rl iH rd iH rH rH iH rH CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM dddddd d H H d d d d d d d d d d d d d d d d d d d d d d d d d d d d H d d d d H zzzzzzzzxxxxaaaaaacococococococoeococococococococjcjcjc cjcjocjocjcjxxxxoooooooocjcjc oo cococ cocoticocoiHHaHaH faiωi-αcα xifaixxxxxxxxxxx xxa ^aacxj tf tf tf tf tf tf tf tf j jcj cocococ co υo HaHaH HaH H HaHaHatf tf¹ tf tf tf tf CJ CJ CJ CJ CM CM CM CM C CM CM tf 333 tf tf rl CM tf a O Ω Ω tf tf cα o tf CQ c tf a CJ Ω ti co tf cQ cj Ω fai co a a tf Ωtf cαo tf mcjΩfa] z υ o o o z υ o z υ o o z υυooozυυcoυoz υυoυυzυoz oυoυzυzz υozooozoooooozυυυυz

O iH CN oO 'T LO Co r^ co cno M CN rO 'tf i co r^ co c o iH CM cO 'tf i co r^ ooc o rH CM r^ ιn ιnιn ιn ιn Ln ιn -o ιn ιnco ιo D i" iocΩCD ioιo or~ r-- r~ r^ r-~ r-- r^ r^ oo∞ ∞ ∞∞ ∞ ∞ ∞ a oo oo ∞oo oo co oooo coco oo oo oo oo co coooco cooooo cooo oo oo co oo oooo co αo co oo ∞ oococ^

2222222 2222222 222222 o o o o o o o o o o o o o o o o o o o o tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

CM CO r^ rl ^

oooooooooooooooooo oooooooooooooooooo OHOl^ϊl co r~ Cn ^ 0O ^ 0O CM rH C r^ O Cn ιH rH CM ιn rH ι 'tf 'tf 0O Cn cn cM 0 CD 0O CD CD rH rH "tf CM I^ ιH 0θ a Cn rH r~

"t_f r^ o o ιn c r oo ri r~ co co c cn o cD io o cD ιn ri Λ rH CD co D θ r^ r-- Ln rH o r ιH "tf θ CN in -tf rH ^ cθ "tf σi '^ ∞ ιn o ιn "tf ιH rH θ co co i" o r~ co o o cN ιH i cn r r ιo cM r cN "tf ^ oo ι cD o oθ ιH ri o cM θo cn r^ cD ιn "tf Vθ ι "tf in ι cD ιn ιn "tf r -<tf ^ 'tf (^ CM ri o c co o e cn co co c ^ 'tf CD CD io r-- r~ r_^ r_^ r_^ D CO VD CO CO l^ CD VD O CO i-D CD CD CD CO CO O CO VO CD D D CD in in VD in in in CD D lD CD VD lD CO CD CD CO CD lD CD ^

CM CM CM CM CM CO CO OO OO OO ro o ^,τ "tf ^ 'tf "tf ^ 'tf "tf '^ 'r ιn ιn ι ιn ιn ιn ι ιn ι ιn ιn ιn cD CD D co [^ r-- r~ r^ r~ r~ -- r^ CN CM CM CM CM CN CM CN CM CN CN CN CN CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CN CM CM CN CM CM CM CM CM CM CM CM CM CM CM CN CM CN CN CM CN CN CM C^

H d H H d d d d d d d d d H d d d d d H d d d d d d d d d H d d dd d d d d d H d d H d d d d d d d d c cjocjcjaaaaaaacocococococococococoaaaaaaaapsaaaxxxxzzzzzzzzzcococococococococo tf tf tf tf aaaosaaa aa ariri iriHriHMriHxxxxxxxx xxxHaHaH HaHaHaHaH H HaHaHaH xx xxx xx μl HI πl H3 tf tf tf tf tf EHEHEHEHHHEHa a ^HHH H HHEHEHHEHEHOOcjc jcjo jcjcjocjcjH H HaH HaH H H H tf tf tf tf rl CM co a a tf m cj o tf a CJ Ω Ω di fai tf a o Q fai Ω Cxi cci a tf tf m j Ω i fa] tf m cj Ω fai co tf m υzzoozυυoυυozoυυυzυzυozouυooυoooυozooo zooυυozυozυυoυυzoozoυoo

00 rH 9 2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

O

^ H ^ ^ ^ ^ H3 ^ ^ ^ ^ ^ H3 Hj H H3 H3 H3 ^ H] H H H3 ^ ^ H ^μ; ^μ: ^μ; H; H] ^μ: β ^ H ^ Hj H H H! H3 H3 ^ ^ H3 H9 H ^ H H β H H H H3 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H P P H P O O O O O CCCDDD CCCDDD CCCDDD CCCDDD IIIDDD u u u M Ni ooJMMJ OOOOOvi OOo N μ o iD θo m w oz

< < < < ^ 3 ^ π3 ^ 'ϋ rj ^ t t lr' lr^< t t-^, lr ^ π3 n3 3 ^ ^ ^ tr^l t -^ t-^| l^ ^ ^ ^ ^ ^ ^ ^ P1 M p] p] p] ] p] ] ^ ^ W ^ p0 p0 ?H _{π P}rj |_?j _{M π π π n s x π ffi m} j_{r ffi K} 5_{C ffi} t-^,t-^,t-^,t-^,oooooooααααcGαcoooooooGσGσGGGσ ]p]p3 ιππ ]pip]p3p]CGcαGGGC 3P3pι ]p)p] ]p3 l-π H^π I-π |-^π |-^J H' l-^π |-^π H.' l-^π H^J r' l-^» l-^J H' l-^π r> l-^π ' r' r' I-π μ-' l-π r^ u u u u ω u ω ωuu u u ω u u ω ω ω u ω u ω ω ω i ω ω u ω ω u u i u ω ω u ω ω u u o -j o o oi mm m m σi m υi ^ w w ω t^ cn ui i-. A Λ Λ Λ Λ i-. ω ω j ω ω ω ω ω M N M M M M N M M M N μ H μ μ μ H h' H O O O O OO OO

O 1 1 1 1 I I I I I I I I I I I I I I I I I I

CO cn cn a-. J-. CO O O CO CO CO O H> co co o μ μ o u ω Nj μ O O O O fc W M U M ' O O O O iC Ul ife. CO H' r' O O H' o o o o cn tΛ W Ui o ifi tΛ ω o ω Λ M M w μ o iD M θ M N μ M co o o ω μ tj> Λ θ ιθ Λ ω uι o μ ω o o m θ M H W U

Λ θ W H θ ω m ω o w ∞ w M oi i o m -j μ ιo ω M ω ιe σι ω θ ι-. o o ιc ω o σι σι o u uι o w cn oo w o ' ii (Ti cn N) ifc -o cn W r' c» it-. N3 N3 io w c3 cn cnc c c c c cn c c c

CH il-. i& W >!-. U> rn cO NJ M

^ ι-- μ M i φ Co σι m o ω ω u o w fc w Nj μ N) o ) -J Φ !jι ιo * ι» w ifl W om o <Λ U

CD J r^, r^,r^,r^l r^, r>ι-'r' r' i--'i--'i--' r*r'r'r'i-'r' l I I I I I I I I I I I I

O Λ m oi w cπ tΛ σi w ui Λ M W H M H M M μ o o o io io -J ω o ^ ω o ra o m n iii Λ O O H O M P N tJ H H O O O o o H H H W i-i ^ fr W o ∞ M H^, Λ ^ >t-. D c M c o ϋJ θθ r' c ι-' >& cD cn oo H^j μ^j --J ' oo c σ^ w ω -j ι-

H^{j j} ιfa ∞ ιi-. c^ W ιfe c ^ c c ιtⁱ ^ ∞ ---J M c ω co o c cn N3 ω cΩ --J cπ c ∞ π co j-. -j i" ^ -j ιt-. -o cD VD C ) cD J σ^ M σ^ σι oo o oD CJ CJ ι ω cn ∞ H^H W σ^ ω ω

I-¹ H¹ H" Hⁱ μμμμμμμμHμ H> H¹ H¹ H> H> r'l-'r'r'l-'r'r' r'. r> r^{1 1} r¹ r¹ ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

IM M M M I M M M W M M M N P μ μ M M M M μ μ M MW μ Nt H M M μ HI W ω ω U W ID M t W N ID t H H H H C M M P W M N MM σi fc o o w m υi m ui ui m ω w M ω m o μ M M μ ^ -j μ o io O H m o o co m μ o NJ O O is ∞ t- w μ o o o o M ω t io ω oj w w μ ifc Λ oi cn μ ιn μ m iD i μ uι ιo o ^ J U θ Λ u)ωa! ιt. o3 μ iD ωw μ θ H U o ω w (Λ μ Λ M o3 iθ j iB m iD Λ Ui θ ι& * μω o ω u w ι-, μ oo MU

P W Uι ω cθ ω θ ιb (31 ιl- H ω ιfc lCl M MlD Ca vl W v| μ μ ∞ Λ ιt> N) O lD H θ ω θ O ) O H lD O W ι-ι ι-> ω N)H φ ι-> O H O O WU

ro o oo ιn ri o σi "t_f CD ^ (^ σι o r σι r^ M in ι^ cD M iΛ iD ro cM θ o r~ -tf CD oo cM H ro cn rH ri ri co ^ "t_{f r}i co ^ r o c in H CΛ cN r_^ co r_^ r^ cD r^ '^ θ ri θ ιH ∞ ri ro cn ιn r~ co ^ cD r~ o cn r~ r~ "tf crι r cτ^

CJ

© ( <3l ω ^ N O H O o^ ιn o » Λ ^ ι ^Bct 'J ln ι ^ ιB ιn σι ln ^ n H (DH OO Λ O O ( co H ^ t» ιn H lf ι ^ ιn f N ι <Jl co W ιn w ^ n © CN CN CN OO OO OO rO rO OO rO CN CM OO CN CN CN OO OO rO rO rO rO OO OO OO OO OO rO CO OO OO CM rO O^

CΛ ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo U PH oo cn ιH oo cD in co o cN r-~ cθ "tf CD c ιn r-^ rH oo cM rH i ιn σι r~ o cM cτ^ ι→ ιH "tf o r oo 'tf r oo ~ ro ro D ∞ _ιH < r~ ^,^ r_^ o cn σι c r--- o ro cn ri ιn <Λ Ω o o ^ o r~ r-- o cM co iD ιn oo 'tf θ CD 'tf r~ -v cn ro co o ιn cM _ιH ιn o ιn o cN P- rH θ _'r cn cN ri cΩ r-- CM CM θ rθ ιH r~ r^,-- r-- ^ oo ιn co c ιn r-- cD oo oo o σι c cD in ιn ι ^ c ro co oo oo cD r^ oo oo oo r~ cD in ι θ rt θ ri rH CM CM "tf 'r ι co ι ιn '^ ι^ rl rl rH iH rH CM rH rl CM CM CM CM CM CM CM CM CM CM CM CN CM CN CM CN CM CM CM rO OO OO rO OO OO OO OO CO OO CO ro m oo n OO OO O^ cM iD co cM ^ θ 'τ r-- r ιH e o r- o t^ o co r^ oo "tf r ιn cn ι oo ιn '^ rH ri r-- cD oo r-- cn ιn o^ r^ D r~ ι-H C^ θ 't_f σι o cD r~ σι r_^ r t^ σ^ ro o ι cD ro oo r cn ιH ri ι ιn "tf r~ "tf i r cD θ D r ιn o o α3 oo -- co cD c "tf θo oo co M ι co ^ιn <i H 'f ^ ω ιn β v N σι o oo H "» iD ω iΛ H ^ N 'f H N 'τ ιn ι ^ H i "» co o w n ω <iι ιn ^ ffl ra (η M ifi ιnθ N N t iB n ιn ιO lnco ^B ^o ^ ιo ^ ^ 3 ω co w (^ CD ^ ω σι O H ^-l N o^ rn o o o o H Λ oo <3l ι^ oo o o r- oo ιD ι ^ ι '^ "t' ( ιn ιn "tf ro ro m in in ri ri o crv oo cD iD cD CD co ιo iD iD "tf 'r "tf "tf "tf '" ^ "tf 'tf "tf "tf ^,^ 'tf in ι ιn ιn ιn ιn ιn ιn Ln ιn Ln 'r 'J^{ι ,}^ ι ^ "tf i "tf 'j" '3^ι ^ "tf 'tf "tf ^ι^, 'tf 'tf "tf 'tf "tf ^ι^, r ro

r-- r~ r~ oo co oo oo oo oo oo co ∞ oo oo oo co oo oo ∞ oo cn cn ^ σι cn cn cn cn cn o o o o θ ιH ri ιH ιH ιH ιH rH CM CM CM CM CN C^

C rO OO n OO OO rO OO O O O O O O O O O O O O O O O O O O O O O rl rH rH rH rl rl rl iH iH iH rl rH iH rl iH iH iH rl iH iH rl iH rl rl iH rl rl rl rl rl rl rl rl rl rl rl rl rl rl O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d dd dd d d d d d d d d d d d d d d d

_^ H aa aa aaaaa aaaaaa ococococo oc coco oco oco oooooooo cococo oco DDDD a a [-icχi wcχi c_{- -} a₍jιi^t aHjιaHia aaHiHi

CM rl rl CM CM rl CM

CJ tf cQ m cj Ω fai Ω Ci t tf tf co o p fai co tf CQ Ω tf m c tf CQ CJ Ω Cxl cO tf CQ CJ Ω Ω tf CO υυozυυυoυυuυυυυoυozυzυooυozυozυυυ z υ υ u υ o o zυυυυυzuozυoooυυozυυ

OOOOOOOOOOOOOO Hddd HddHd HHdrid

o222o2222 HoEH EoH Ho2 Ho222222 EH EoH EH Eo EoHoEHoHoEHoEH EoH tftf tf tf tf tf tf tf tf tf tftf tftf

rθ rH "tf cn o co ∞ o rH o ro c ro in

Lθ Ln cn oo cM oθ i σ^ co cn oo co co oo oo r^ cD io oo r^ co i co vD Ln ^ ri cO 'tf r cN C iH iH o o σi CJi r^ co r^ o σ^ rH iH r M oo oo ro ro oo oo oo oo ro oo oo ro oo ro oo oo ro oo oo oo oo oo oo oo ro oo ro ro ro ro cM CM CN CN CM ro cM r^ π "J^ι ^ o ιn H ι t (Λ lD ^I) o o ^ ιn o oo c^ Λ ιn H ^D lD ιη N ^ [>J m H ri O "l' N O (o ω ιn o ^ ιo ι l ιn o o co n oo ιo o H Ol tη H ^ co ^ ^ι r" rθ "tf r~ o ι^ 'r D (η co r~ ιH rH in D r^ [~ r cM oo cD ri r-- ιJ3 cD CM C3^ ovi o o cN ri r-~ m cM θ cD σ^ ιn '^ oo ιn ∞ cM ro co αo i ιn «tf ιH oo 'tf M rH cn ιn ιn ιn r^ ιn ι 'tf CD rH "tf r~ 'tf θ rH ri σi rH σ^ cN ιH Ln r^ ιH ^ CM in ιH CD 'r ^

0

I CM O r-- CD >O ιn 'tf CN CN ιH CN O O O ιn ιn ιn ιn C0 l0 ^ r0 M CM CN r0 CM O C0 CN '"tf 'tf C0 'tf Cvl rl CM ιH rH O ιH rl CN ιH 00 ^ ιn 'r ^

^■» N d M O O d d oDDDDaaaaaaaaaaaacocococococoaaaaaazzzzzzzzxxxxxxxxcococococococococococxicxifaifaifaicx] fa]fa]fa]faiiiixxxxxxxxxxxxxxxxxxfa]iafa]fa] χifaicoc co ococo ocθH iHHaH ι-iiHH H iHHririBaa r HaH H HaEHEHEHEHEHEHEHEHEH HEHEHO u ocococococotf tf tf tf tf tf tf tf c c c c c c a aa aaaaaaa rl CM rl rl CM CM rl CM CM rl H CM rl CM

CJ Ω Ω tf c fai Cxi cj tf m cj tf a cj tf a O Ω Ω tf tf tf a CJ Ω Ω Cxl fa] tf a CJ p p ooυoozυυoυυoυoooozoυcoo z o o o o o υ υ υ o z oozooozυυo uυouzυzυo z υ υ o o o ^ "»^ <J sl' " "tf"''tf«"'tf«imnimn 'un'm" i-'oi rl rl rl rl rl rt rl

Table 2

ATOM 1155 CE1 PHE 1022 3. .713 42. 791 40. 930 1. 00 35. 49

ATOM 1156 CE2 PHE 1022 2. ,655 40. 899 41. 966 1. 00 36. 57

ATOM 1157 CZ PHE 1022 2. ,568 42. 062 41. 213 1. 00 35. 79

ATOM 1158 C PHE 1022 8. .058 38. .916 42. 842 1. ,00 27. 74

ATOM 1159 0 PHE 1022 8. .386 38. ,978 44. 037 1. ,00 28. 42

ATOM 1160 N LEU 1023 8. .905 38. .586 41. 869 1. .00 26. 44

ATOM 1161 CA LEU 1023 10. .294 38. .278 42. 173 1. ,00 25. 87

ATOM 1162 CB LEU 1023 11. .070 38. ,015 40. 885 1. ,00 22. 37

ATOM 1163 CG LEU 1023 12. .441 37. ,371 41. 093 1. ,00 24. 38

ATOM 1164 CDl LEU 1023 12. .332 36. ,176 42. 043 1. ,00 20. ,70

ATOM 1165 CD2 LEU 1023 13. .002 36. .951 39. ,743 1. ,00 23. ,30

ATOM 1166 C LEU 1023 10. .898 39. .457 42. ,948 1. .00 25. .50

ATOM 1167 O LEU 1023 10. .807 40. .608 42. ,516 1. .00 24. ,70

ATOM 1168 N ARG 1024 11. .489 39. .150 44. ,104 1. .00 27. ,06

ATOM 1169 CA ARG 1024 12. .092 40. .149 44. ,998 1, .00 26. ,64

ATOM 1170 CB ARG 1024 11. .282 40. .229 46. ,301 1. .00 24. ,40

ATOM 1171 CG ARG 1024 11. .960 41. .004 47. 407 1. .00 19. ,74

ATOM 1172 CD ARG 1024 10. .992 41. .364 48. ,527 1. .00 17. 02

ATOM 1173 NE ARG 1024 10. .461 40. .193 49. .219 1, .00 19. ,05

ATOM 1174 CZ ARG 1024 9. ,777 40. .245 50. ,363 1, ,00 21, ,94

ATOM 1175 NH1 ARG 1024 9. ,541 41, .407 50. ,955 1. ,00 20. ,91

ATOM 1176 NH2 ARG 1024 9. .310 39. .137 50. ,919 1, ,00 25. ,83

ATOM 1177 C ARG 1024 13, .548 39. .873 45. ,348 1, ,00 24. ,92

ATOM 1178 O ARG 1024 13. .932 38, ,729 45. ,586 1, ,00 27. ,55

ATOM 1179 N ILE 1025 14. .355 40. ,925 45. ,376 1. ,00 25. ,20

ATOM 1180 CA ILE 1025 15, .770 40. .791 45. ,734 1. .00 27. ,59

ATOM 1181 CB ILE 1025 16. .704 41. .245 44. .581 1, .00 27, .75

ATOM 1182 CG2 ILE 1025 18, .162 41. .066 44. .994 1. .00 27. .22

ATOM 1183 CGI ILE 1025 16. .424 40. .431 43. .313 1. .00 25. .51

ATOM 1184 CDl ILE 1025 17. .321 40. .810 42, .144 1. .00 22. .73

ATOM 1185 C ILE 1025 16. .059 41. ,656 46. .966 1. .00 27. .93

ATOM 1186 O ILE 1025 16. .398 42. ,837 46. .837 1. .00 28. .55

ATOM 1187 N LEU 1026 15. .901 41. .067 48. .152 1. ,00 29. .13

ATOM 1188 CA LEU 1026 16, .133 41. .764 49, ,420 1. .00 30. .12

ATOM 1189 CB LEU 1026 15. .744 40. .864 50. .583 1. .00 30, .24

ATOM 1190 CG LEU 1026 14. .253 40. .510 50. .579 1. .00 30, .34

ATOM 1191 CDl LEU 1026 13. .980 39. .378 51. .578 1. .00 29, .27

ATOM 1192 CD2 LEU 1026 13. .432 41. .759 50. ,909 1. .00 24, .29

ATOM 1193 C LEU 1026 17. .594 42. .202 49. .544 1. .00 30. .91

ATOM 1194 O LEU 1026 18. .512 41. .436 49. .235 1. .00 29. .93

ATOM 1195 N PRO 1027 17. .822 43. .438 50. .015 1. .00 31. .36

ATOM 1196 CD PRO 1027 16. .754 44. .228 50, .666 1. .00 30. .05

ATOM 1197 CA PRO 1027 19. .127 44. .086 50, .212 1. .00 30, .53

ATOM 1198 CB PRO 1027 18. ,771 45. .368 50, .963 1. .00 29. .38

ATOM 1199 CG PRO 1027 17, .520 45. ,004 51, .693 1. .00 30. .61

ATOM 1200 C PRO 1027 20. .250 43. .282 50, .879 1, .00 30, .41

ATOM 1201 O PRO 1027 21. .415 43. .650 50, .804 1, .00 30. .55

ATOM 1202 N ASP 1028 19. .897 42. .175 51, .509 1, .00 31. .88

ATOM 1203 CA ASP 1028 20, .865 41. .316 52, .175 1, .00 33. .73

ATOM 1204 CB ASP 1028 20, .212 40. .774 53 .421 1 .00 36, .11

ATOM 1205 CG ASP 1028 18. .770 40. .437 53, .182 1 .00 40, .54

ATOM 1206 OD1 ASP 1028 18, .502 39. .362 52, .595 1 .00 39, .57

ATOM 1207 OD2 ASP 1028 17. .907 41. .273 53, .546 1, .00 44, .85

ATOM 1208 C ASP 1028 21. ,294 40. .154 51, .273 1 .00 34, .93

ATOM 1209 O ASP 1028 22. ,074 39. .292 51. .679 1, .00 35. .53

ATOM 1210 N GLY 1029 20. ,771 40. ,129 50. .054 1, .00 35. .81

ATOM 1211 CA GLY 1029 21. .110 39. .070 49. .125 1, .00 34, .91

ATOM 1212 C GLY 1029 20. .015 38. .025 49 .017 1 .00 35, .42

ATOM 1213 O GLY 1029 20. .078 37. .159 48 .150 1 .00 33, .85

ATOM 1214 N THR 1030 19. ,012 38. .104 49 .890 1, .00 36, .08

ATOM 1215 CA THR 1030 17. ,907 37. ,143 49, .885 1, .00 36, .46 Table 2

ATOM 1216 CB THR 1030 17. 082 37. 217 51. 204 1. 00 39. 04

ATOM 1217 OG1 THR 1030 17. 765 36. 484 52. 229 1. 00 37. 14

ATOM 1218 CG2 THR 1030 15. 668 36. 638 51. ,012 1. 00 37. 72

ATOM 1219 C THR 1030 16. 952 37. 322 48. ,711 1. 00 36. 12

ATOM 1220 O THR 1030 16. 364 38. 393 48. ,535 1. ,00 37. 82

ATOM 1221 N VAL 1031 16. ,797 36. 256 47. .925 1. ,00 34. 66

ATOM 1222 CA VAL 1031 15. .914 36. .241 46. .757 1. ,00 32. .25

ATOM 1223 CB VAL 1031 16. .622 35. .588 45. .557 1. ,00 32. .21

ATOM 1224 CGI VAL 1031 15. .617 35. 305 44. ,443 1. ,00 28. 71

ATOM 1225 CG2 VAL 1031 17. ,742 36. .502 45. ,069 1, ,00 27. 43

ATOM 1226 C VAL 1031 14. ,622 35. ,481 47. .079 1. ,00 31. ,61

ATOM 1227 O VAL 1031 14. ,644 34. ,315 47. .485 1. .00 31. ,86

ATOM 1228 N ASP 1032 13. .493 36. ,145 46. .882 1. .00 29. ,65

ATOM 1229 CA ASP 1032 12. .207 35. .538 47. .204 1. .00 28. .58

ATOM 1230 CB ASP 1032 11. ,959 35. ,656 48. ,707 1. .00 27. .71

ATOM 1231 CG ASP 1032 11. ,545 37. ,075 49. ,125 1. .00 27. .66

ATOM 1232 OD1 ASP 1032 11. ,886 38. ,060 48. .418 1. .00 26. .65

ATOM 1233 OD2 ASP 1032 10. ,880 37. ,203 50. .170 1, .00 22. .45

ATOM 1234 C ASP 1032 11, .082 36. .258 46. .471 1, .00 28. .37

ATOM 1235 O ASP 1032 11, .330 37. .059 45. .572 1, ,00 26, ,82

ATOM 1236 N GLY 1033 9. .847 35, .988 46, .892 1. .00 27. .76

ATOM 1237 CA GLY 1033 8. ,698 36. ,612 46. ,267 1, ,00 26. .49

ATOM 1238 C GLY 1033 7, ,779 37. ,247 47. ,277 1. .00 26, .11

ATOM 1239 O GLY 1033 7. ,820 36. .912 48, ,458 1. .00 27. .57

ATOM 1240 N THR 1034 6. .956 38. .178 46, .805 1. .00 26. .39

ATOM 1241 CA THR 1034 5. .987 38, .882 47. .646 1. .00 27. .75

ATOM 1242 CB THR 1034 6. .576 40, ,181 48. .236 1. .00 28. .31

ATOM 1243 OG1 THR 1034 5. ,508 41. .047 48. ,646 1. .00 30. .58

ATOM 1244 CG2 THR 1034 7. ,439 40. .890 47. .216 1. .00 30. .03

ATOM 1245 C THR 1034 4. ,742 39. .247 46. .846 1. .00 27. .63

ATOM 1246 O THR 1034 4. .775 39. .294 45. .619 1, .00 31. .50

ATOM 1247 N ARG 1035 3. .641 39. .502 47, .532 1, .00 24. .78

ATOM 1248 CA ARG 1035 2. .423 39. .864 46, .837 1, .00 25. .50

ATOM 1249 CB ARG 1035 1. .249 39. .046 47, .371 1, .00 25. .09

ATOM 1250 CG ARG 1035 1. .349 37. ,553 47, .119 1, .00 23. .18

ATOM 1251 CD ARG 1035 0. .085 36. .839 47, .606 1, .00 27. .17

ATOM 1252 NE ARG 1035 -0. .011 35, .491 47, .048 1, .00 31, .66

ATOM 1253 CZ ARG 1035 -0. .103 34, .377 47, .771 1, .00 33, .76

ATOM 1254 NH1 ARG 1035 -0, .122 34. .422 49, .101 1, .00 34, .54

ATOM 1255 NH2 ARG 1035 -0, .146 33, .204 47 .162 1. .00 35, .20

ATOM 1256 C ARG 1035 2. .130 41, .348 46, .992 1, .00 27. .20

ATOM 1257 O ARG 1035 1. .005 41, .785 46, .805 1, .00 28, .13

ATOM 1258 N ASP 1036 3. .150 42, .127 47, .332 1, .00 31, .07

ATOM 1259 CA ASP 1036 2. .989 43, .568 47, .521 1, .00 32, .80

ATOM 1260 CB ASP 1036 3. .524 43, .959 48, .887 1, .00 35 .64

ATOM 1261 CG ASP 1036 3. .599 45, .457 49, .067 1, .00 40, .73

ATOM 1262 OD1 ASP 1036 4. ,229 45, .893 50 .064 1 .00 41 .06

ATOM 1263 OD2 ASP 1036 3. .028 46, .186 48, .217 1, .00 36, .48

ATOM 1264 C ASP 1036 3. .699 44, .396 46, .445 1, .00 33, .66

ATOM 1265 O ASP 1036 4. .923 44, .336 46, .309 1, .00 34, .64

ATOM 1266 N ARG 1037 2. .931 45, .185 45, .700 1, .00 33, .72

ATOM 1267 CA ARG 1037 3. .496 46, .000 44, .626 1, .00 32, .18

ATOM 1268 CB ARG 1037 2. .438 46, .321 43 .563 1, .00 31, .11

ATOM 1269 CG ARG 1037 2. ,015 45, .120 42, .750 1, .00 31, .44

ATOM 1270 CD ARG 1037 1. .118 45, .481 41, .571 1, .00 32, .91

ATOM 1271 NE ARG 1037 1. ,828 46, .167 40, .492 1, .00 32, .28

ATOM 1272 CZ ARG 1037 1. .478 46, .085 39, .208 1, .00 32, .10

ATOM 1273 NH1 ARG 1037 0. .434 45, .346 38, .848 1, .00 25, .01

ATOM 1274 NH2 ARG 1037 2. ,167 46, .745 38, .286 1, .00 32, .51

ATOM 1275 C ARG 1037 4. .120 47, .295 45, .087 1, .00 31, .28

ATOM 1276 O ARG 1037 4. .809 47. .958 44. .313 1, .00 29. .49 ω ι o n v H (η H

oooooooo oooooooo oco tnH o ιn (η ) Nn iDCD "t_f '_tf co cN c c ιH c o ∞ c rH o "tf iD 'tf θ rH oo iD c r c c C ∞o r~ o rθ ri cn c oo coι co roι^ r~ rH co oo c "tf r t~ i ^ i rH H rH co co cM CD O r~ oc cn ^ '^ ocM r r~ r^ ri o cM r co i i cM o cD ro ^ iD cn in co co in ro oo oo r^ iH Oin "tf rH oo oo cnin co ooooo "tf OO rHCM Coco o cN cn r~ iH cn r^ oo co ri r^ cDCM co r^ r^ ∞cn cooo cnr-- co ιn 'tf in "tf r^ r^ <)oo cn r~ oo o ιn ιn ιn cD CD r^ r^ ^,^ r ιn "tf o cN i^

"tf 'tf 'tf "tf "tf ^ ^ ^ 'T 'tf '^ 'tf ^ ^ "tf ^ ^ ^ 'tf "tf "tf 'tf ^ ^ ^ "tf ^,tf 'tf '^ "tf "tf "tf ^ ^ ^ "tf 'tf "tf 'tf ^ "tf "tf ^ ^ 'r ^ ^,^ "tf "tf ^ 'tf "tf ro∞r_^ c o ιn "tf r ιnιH ' rocN coθ ιHom r cn r--- cN cθ rH H ' r co co ∞r o "tf tn ι^ r^ ι or ooιn -^ CM CM ri 'r c e»oo ιn - o c co θ _"tf i~ ιH rH CD Cθr~ cn rH ro cNr cD coc "tf σ r-~ 'tf CD oo o^ oo "tf in rH oo m ri _"tf inoo oor~ m "tf "tf m cMCD "tf in cDro o oo ιnr 'tf. rπ cooιn ooo cM r~ r-- cD ri "tf 'tf rH θ oo ι-H ∞ oo oo o oo cN cn ri r 'tf CD θ c3o oo o ro r-- rθ "tf ro oo ιn cD io r~ r-- cocn co co oo cn θ ιH ri cM ι→ cM rθ "tf in oo -w ιncM CM ιH o σιoo oocD oθ ιH ri ri o o o σι CN ro c^

(D ω ω ω ω ι ιn ιn ιn ιn ι ui o o o M o o o o o o o o o o o o

H d d d d d d d d d d H aaa a aa iia Maaazzzzzcoco oco oco oc cococii ifaifaifaicxicifaizzzz zzz DDDDDDDDzz zzzz uωωωwωt mMwωnnMaiiHiaaHHHHHHHH^μHjaiiJ^HihihiJ^^a^aaajωHt-WKWi-tii^aaHiaiaHi coc c c c cotf tf tf tf tf tf tf tf oo a a MHiHM iHOooo ooHaHaH H H i-aHaH ooo o z zo zoυo z υ υ υ υ o zυυυυoυozυoυυoz o iH C^ d d dd d NN N r <^ NNN NM m (η n (ηt π n rO OO rO rO rO rO OO OO rO H d H d d d d d rt d d d d H d d d d d d d d d d d d d d

222222222 2222222 O OOOOOOO O O O O O O O O tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

Table 2

ATOM 1338 C GLN 1045 16.856 45.230 34.423 00 26.34

ATOM 1339 0 GLN 1045 18.035 44.977 34.700 00 26.34

ATOM 1340 N LEU 1046 16.185 44.597 33.464 00 25.58

ATOM 1341 CA LEU 1046 16.806 43.549 32.666 00 23.78

ATOM 1342 CB LEU 1046 15.732 42.647 32.046 00 22.97

ATOM 1343 CG LEU 1046 15.147 41.560 32.960 00 23.09

ATOM 1344 CDl LEU 1046 14.469 42.162 34.174 00 17.46

ATOM 1345 CD2 LEU 1046 14.167 40. 733 32.163 00 25.21

ATOM 1346 C LEU 1046 17.661 44.171 31.581 00 22.40

ATOM 1347 O LEU 1046 17.311 45.223 31.047 00 19.22

ATOM 1348 N SER 1047 18.782 43.524 31.269 00 23.55

ATOM 1349 CA SER 1047 19.699 44.017 30.237 00 26.45

ATOM 1350 CB SER 1047 20.830 44.820 30.871 00 21.82

ATOM 1351 OG SER 1047 20.423 45.328 32.123 00 25.79

ATOM 1352 C SER 1047 20.300 42.850 29.460 00 28.44

ATOM 1353 O SER 1047 20.522 41.775 30.018 00 29.64

ATOM 1354 N ALA 1048 20.578 43.064 28.178 00 30.05

ATOM 1355 CA ALA 1048 21.158 42.009 27.358 00 31.08

ATOM 1356 CB ALA 1048 20.510 42.002 25.973 00 29.58

ATOM 1357 C ALA 1048 22.670 42.151 27.225 00 33.28

ATOM 1358 O ALA 1048 23.180 43.165 26.741 00 33.23

ATOM 1359 N GLU 1049 23.395 41.140 27.679 00 35.86

ATOM 1360 CA GLU 1049 24.844 41.163 27.555 00 38.31

ATOM 1361 CB GLU 1049 25.467 40.164 28.532 00 43.39

ATOM 1362 CG GLU 1049 26.992 40.046 28.448 00 52.18

ATOM 1363 CD GLU 1049 27.706 41.401 28.409 00 57.15

ATOM 1364 OEl GLU 1049 27.319 42.318 29.172 00 60.15

ATOM 1365 OE2 GLU 1049 28.667 41.542 27.619 00 58.73

ATOM 1366 C GLU 1049 25.121 40.746 26.111 00 36.83

ATOM 1367 O GLU 1049 26.063 41.211 25.471 00 36.38

ATOM 1368 N SER 1050 24.253 39.868 25.617 00 34.63

ATOM 1369 CA SER 1050 24.316 39.328 24.271 00 30.69

ATOM 1370 CB SER 1050 25.168 38.061 24.245 00 32.49

ATOM 1371 OG SER 1050 26.415 38.268 24.883 00 36.39

ATOM 1372 C SER 1050 22.880 38.962 23.939 00 29.47

ATOM 1373 O SER 1050 22.015 39.005 24.818 00 27.73

ATOM 1374 N VAL 1051 22.627 38.601 22.682 00 27.04

ATOM 1375 CA VAL 1051 21.282 38.226 22.256 00 22.31

ATOM 1376 CB VAL 1051 21.260 37.727 20.774 00 21.56

ATOM 1377 CGI VAL 1051 19.845 37.323 20.367 00 20.09

ATOM 1378 CG2 VAL 1051 21.762 38.801 19.851 00 19.56

ATOM 1379 C VAL 1051 20.812 37.093 23.157 00 21.36

ATOM 1380 O VAL 1051 21.564 36.147 23.405 00 20.77

ATOM 1381 N GLY 1052 19.589 37.206 23.666 00 20.09

ATOM 1382 CA GLY 1052 19.023 36.166 24.512 00 20.83

ATOM 1383 C GLY 1052 19.501 36.003 25.947 00 22.14

ATOM 1384 O GLY 1052 18.819 35.359 26.744 00 21.79

ATOM 1385 N GLU 1053 20.660 36.564 26.281 00 24.79

ATOM 1386 CA GLU 1053 21.215 36.454 27.631 00 27.88

ATOM 1387 CB GLU 1053 22.706 36.163 27.553 00 26.83

ATOM 1388 CG GLU 1053 23.068 35.352 26.346 00 30.13

ATOM 1389 CD GLU 1053 24.499 34.877 26.370 00 34.21

ATOM 1390 OEl GLU 1053 25.405 35.697 26.646 00 37.12

ATOM 1391 OE2 GLU 1053 24.715 33.677 26.100 00 36.45

ATOM 1392 C GLU 1053 20.988 37.767 28.370 00 29.37

ATOM 1393 O GLU 1053 21.326 38.842 27.863 00 30.58

ATOM 1394 N VAL 1054 20.446 37.684 29.579 00 27.70

ATOM 1395 CA VAL 1054 20.139 38.896 30.313 00 26.97

ATOM 1396 CB VAL 1054 18.602 39.150 30.335 00 27.40

ATOM 1397 CGI VAL 1054 18.023 38.965 28.954 00 29.21

ATOM 1398 CG2 VAL 1054 17.916 38.209 31.313 00 25.23 t <N

C-- SB θ ιH i oor "tf oo o cocD 'r σ^t^ cM i r~ o ∞ Lncn rH rocD o ιn ovi rH 'r "tf ri ri ooco cM co oroco o o ιn r^ r-- r^ r~ ιn c_N(^ ιH oo r-- r--- θ ιH 'tf r~ co oo oocD oocN in θιH θ 'r r--. o cn ro ∞ ri oo ιnco "tf co cD ∞oo oo cN σιc^

CJ r-- σ ∞r-- coOTcn oo ιH<^ <^ cnr"-- ' coro o r~ α3r-- co σ> co r-- o cN Cθ co oor--- vocn ocn o (MCMCM CM C^ CM CM CMCOCM CN CNCNCMCM CM CN rH rHrl CM CN CM CM CO r r OOOOCMCM CMrOCN CNrOnOOOOrO rOrO r^

CΛ e OOOOOOOOOOO o- o_o_o_ o_ o_o_o_ o_ ooooooooooooooooooooooooooooooooooooooooo

H o o o o o o OOOOOOOOOOOOOO ooooooooooooooooooooooooooooooooooooooooo υ i-H rl rl rl rl rt rl rl rl rl rl rl rl rl rl rH rl rl rl rl

PM o o of'l rHCN CNco rooθ 'tf θ CNCM CM CM 'tf ro ιnco cD r-- ιn ιn r~ cor~ c»oor^ oooocncn m rom ooro ro oo ro oo oo oo oo oo oo oo oo oo oo oo ooro ro rooo roro oooo oocooo o "tf ^ 'tf _"tf "tf _"tf 'tf 'tf 'tf "tf θ "tf "tf

oo o ooc- oo H M σιooo t»c•

0000 "tf "tf cDro r^ ooc rH rH "tf ιn i o ocN ^ ιH '^ oo oc r^ CM oo oo n c ι > o o ^r r^ o ooo cn "tf co cn o cM ^ co ιn r-- oιn rH r--- o r-- co oo 'r cocn cn 'j<t~ rovo o cM Lθ r^ ιo r~ r^ i H in c in o co cN i oo oo Do ιn cM ιH "tf r^ ocD θ "tf C 'tf C cn ιH '^o ooθ ιH CMco -tf in "tf in co r-- cn oo cn co r--- cD r~ cDoooooo cnoθ riri ri oo r--

CN CM CM CM CN CM CM CN CM CM CM CN rl rl rH rl rl rl rl rl rH rl rl rl CM CM CM CN CM rl rl

' 'tf in Lθ Lθ ιn ιn tn ιn ιn ιn ιn ιn ιn <o D io ιoιocoiD o ininin in in in in in in in in in in in in in in in in in inin o oo oo o o o o o o oo o o o o o o o oo o o oo oo ooo oo ooo oo

H d H H d d d d H H d H d d d d H d d d d d

,-aι-aa aaaaaa c, a ^χi ^χi χi fa] fa] fa] c-] fa] co c co co c co c o a a a a a a a a a a a D D !D D D D tf tf X X X X X X X X X . x .x .x Ha Ha Ha H H Ha Ha i-a x x x x x x ω fai ω fai fai fai a a Ha H H i-a Ha Hi EH EH EH M H M Hi H Hi M Hi Ha Ha H H Ha Ha Ha i- o co co co co co EH EH H EH EH EH EH Cj cj j c c o rrll rrll CCNN CCMM CN rl rl rl CM rl CM rl CM tf m cj Ω Cxi P fai co a tf a cj o p tf m o Ω Cxi co tf a cj tf a o c tf a cj Ω Cxi ed tf ω c cj oozυυoυυυoυoυozυυooυυozoυυυυzoozυυoυozυooυυozoυυυooυozυυoυυ o z

^ w i in ro _*tf 'ji d d d

2o2o2o2o2oo22o2o2o2o2o2o2o2oo22oo22o2o2o2oo22o2o2o2o2o2o2oo22oo2 tftf tftf tf tf tftftf tf tf tf tf fttf tf tf tf tf tf tf tf tf tf tf tf tftf tf tf tf tf

cn ιH oo o oo r~ cN C r oo c oθ 'τ oo r~ o ι r~ "tf < ι σ^ iD CN r~ cM ^ CN ri oo ( cθ ιH σ^ ιn r~ θ ιH oo ri oo ιn c^ o d (Jl o^o ι (J "l' ^ ιn m <» o ι N cn ιη oo σι ^ o ιn ι H ιn o o α3 ιn H < ι '» d ω Λ ^^ c^ι ι ι (O ^ co H N ln ιJl co N N co ^ ^ ^ c^ r- ^ iji o o W 'i' ^ oi rii ^ Λ v in 'T in oo ^ ∞ ^ o iif o oi m d in ∞ Λ ij o m ω ω ^ ω o σi in o oi tη o io v ω iD H ^ N 'f n in m ω cM C CM ro O 'tf m D i— r~ ri o cyi oo cn oo r— cD r— cD O ri o o cn cn ri cn cn oo o o o ri ri O ri o en en rH o cN ro ^r in cD -tf CN ri cN CM CM CN ri cM CM ro

^J* ^5* ^3* ^* ^3* ^ * ^P ^J¹ * 'tf -^' oo ro oo co ro oo ro oθ "tf 'tf 'r "tf ro oθ 'tf θo oo rθ 'tf 'tf ')' ^r 'r "tf 'tf "tf 0 'tf 1i "tf ^,tf 'tf ^ⁱ ^ 'J¹ ^t* 'J "tf 'tf "tf ^¹ ^ ^¹ ^l¹ ^Ji ιn cn ιn cN θ C cn cM -^ r^ D co cn r^ 'tf θ ∞ cM in rH CD σi rH r-- r r-- ιn co o ι "tf D oo rH r--- r cN θ r( ^ "tf oo o r^ ιo cn ιH "tf CN ^ cn o ιn ιn ri ιH C cn cD CM oo 'tf c rH rH r^ o r ιn oo u o rM CM CN i r-- [-^ ιn o c» o cM ^

Ln iH Ol i C» CN C» rH O CD rH iH CO O CN iH "tf in in CD O in ^ CM O CD 'tf Ln CN rO CN CN CD CO r-- CD in CO CM CO "tf r-. iD in ιn ro co ro oo cN oo ro oo cN ιH rH CN ro ^ cM rθ "t_f Ln o cn en co oo cD cD CD r--- r~ co ιn ιn ro ro cN ri o cn ∞ 't_f -t_f ^ "tf 'T 'tf 'tf -^ -^ "tf "tf "tf "tf -^ "tf 'j^, 'tf "tf "tf "tf "tf "tf "tf o o o r ro oo o o r r r o m cn r~ cn cn .n r~ cn in c cD r-- ^ in rH cM o in «tf o "tf 'tf CN 'tf rH ro o cN CN r~ r^ ιH O CO CD CD σ\ 'r r^ O CO OO Cn θ CD cn rH "tf CD rH CM 'tf CN r~ ιn CM CM Cθ rθ (^ '^ CM rH CD rθ CM <^ CM C~ ιn ιn CO OO O O^ r_^ ^ in o 't_f oo rH CD O in ^ 'tf o cN oo i σi in D O 'tf oo in cn in i^ 'tf r^ ^ 't_f CM CM CD ∞ o in r co e '^ oo cD iD r^ co o ri rH CN rθ ri ri cM CM ι-H ri o co o "tf r Ln ^ ro oo r ιn ^i' CD cD r~ oo oo ιn ιn «tf iH M CM CM CM CM CM CM CM CM CM CM CM rl CM CN CN CM CM CN CN CN CM CM CM CM CN CM CM CM CM CM

CN CN CM ro c r o e r c r o "^»i ^_^. «^r "^»r "^j "T 'r ^,τ '» ^ "r "r ιn ιn ui ι ιn ιn ιn ι Φ ω cB ifl io r~ t ι t ι ^ r^ t^ co oo ra ω oo oo a) co m o'ι t3i (ri (3i w oι o

CO CD ID CO VO CD CO CD CD CO ID VD CCOO CCΩD lCOD lCOD lCOD C—O C —O C —O C —D C _O l _O lΩ CD lO lO CO UJ CO CO CD lO CO CO CD lO CD CO CO ^lΛ CD lO CO lO lO lO lO lO l^ o o o o o o o o o o o o ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooo x xz z z z z z z z zaa Scx aod aaa a a a oD DD D DDDtf tf tf tf tf EH EH EH EHH H EHH a aa acMi-j M a a cώa ac-s a aD, j aiJjaaiaa aj aa^^ ^^ ^^^ ^^ ^^ ^ Mωuωω aw ωi-i aaaauH WMω wiaω w inwwwωtn ϊ sxaffi

O Cj J OO OOOO OOOEHH EHEH EH EH EH EH EH EH EH EH Ha H H ιJ Ha Ha Hl H tf tf tf tf tf 22 tf tf tf tf tf tf tf tf EH EH H HH EH Htf tf tf a CJ Ω fa] fa] tf a cj Ω fa] P cχi co a tf a cj Ω Ω tf a tf ffl cj Ω fa] tf m c p p tf a cj o υ CJ ozuυoυozυoz ouoυoυυυoooz υυυoυoozoυυo υυυcoυυozouooooo zυυoυooz

r se 2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

Eι E< H H tH ^ Eι H tH ri H H tH £H H EH tH tH EH tι H tH H H B H tH H H B tH EH h H H H h h h tH t< h Fι h tH h tH H H tH h tH tH [H H H [H tftftftftftf tftftf tftf tf tf tf tf tf tftf tf tf tf tf tf tf tf tf tf tf tftf tftftftf tftf tftf tf tftf tf tf o

co i

Hι ιnσι

'T inco r-- Drn ro ro

'T 'tf 'tf 'tf 'tf "tf 'tf 'tf ω _'a^, oo

(D O

"tf CM ι

"tf i co ιn nt

OOOOOOOιHrHιHrlCNCNCMCNCMCNCMCN0000r0r0000000r0'tf" "tf"tf'tf'^'r'""tf'tf'^^-0

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO ddddddddddddddddddddddddddddddddddddddddddddddddddddddddddddd aaa iaaxxxxDDDDDDDDDDDDDDDDaaaaaaps os aaxx xosa ososazzzzz zzzaao

MOTcowOTOTOTH H H ra 3fa]fa] Jfa]fa] qfa] Jfa]rdfa]fa]fa]fa]fa]x tf tf tf tf tf tf tf cj c OH H HaHaH HaHaπ i- HaHiiaHaH HaH HEHEHHEHEHEHEHEHEHEHEHO uoco ococo c jcjc^ rl CM rl rl CM CM rl CN tf a cj Ω Ω tf tf w, a u-i <J Ω HI Ω HI ^ μ aj u O Ω i Ω i- tf a cj p cxi Ω fai co tf tf a CJ tf oΩfai i tf m υυυooυozou Z O O O O O O O Z υoooooozoυυυoυυooooz O O z o o o o o zooooozoozυo

H( tn"iι D ι Φ i co σιθH

CM CMCM C CMCM

-o ιntn Lθ Lθ -o

HHddHd d dddHdd

2222222222222222222222222222222222222222222222222222222222222

H ooHoEHoEHoEHoEHoHoH EoHoHoEHoHoEHoHoEHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoEHoEHoEHoHoEH EoH EoHoEHoEH EoHoEHoEHoEHoHoEHoEHoEHoEH HooEHoEHoEHoEHoEHoEHoHoEHoEHoHoHoEH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

•a ι ιn

© CO OC_N O _"tf CD uθ o ooooooroi ro ro

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO J dddHHHHdddHHHHddddHHdddddddddHdddddHHHHddHdHdHdddHdHdddddddHd ιo

"tf cn co rH rocN ri ri ri roro cM CM rθ"tf inιn cD r-- r-- ri

"f ^ ^ 'r rnnt con M n tn mrnfn ^ t'nrn r ro rnrnntn n i'ioionf rotn i ^ 'i¹ "tf oo oo oo oo oo oo oo oo oo oooo ro oo oooooooo oooooo oooo oo roco ro

ιn o o r~ cn o r~ o oo o oo r^ ιH o oo cD r^ r-- o ιn r~ ro cD r^ cM co "tf r~ ι cM 'tf in ∞ cD ιH oo o ^ cM ιH "tf ιH cn "tf i^ cN CM ^ r~ r- cD co ιn oo 'tf σ^ cD i" oo r cM θ CD CD θ ri ι "tf rH C CM r~ cN ro o r~ r r ∞ r^ r~ oo ι cD θ ι ιn ιn ri o o cN CD c r~ cτι ro r cn cn co rH cθ 'r ^ ∞ σ^ ri ^ ^ cM Co r~ ιn r t--- cn cθ Ln σi ri o c ri cD ι ^ o ^ o o co oo oo co r"- r~ oo co oϊ co cΛ <Λ oo co co oo [~ <Λ oo θ ri θ ιH θ r~ co ι^ vD co t~ c^ r~ r"- ιo ^ ιo ^ rO rO CN CN CM CM CM CM CM CM CM CM CM CN CM CM CM CM CN CM CM CN CO rO OO OO CM CN CN CN CN CM CM CM CM CM CM CM CM CM CM C^

∞ ∞ ∞ OO Cn OO CΛ Cn cn Cn Cn O O O O O O O O rH rH rH rH rH rH rH iH rH CN CN CN CM CN CN CN CM CM OO OO CO rO OO eO ^ '^ ^ ' _^Vι<_"tf 'tf ^^ι^^,mmι mιnιnmmιnm r-~ r^ r~ r- r--- r^ r^ r-- ["-- r^ r~ c» oo oo co co co co oo co oo oo cD co co co co oo oo Q Q O Q Q Q r^ r-^ ^ -i - ^ i— i i^-i i— ι -ι ^ ι— ι ι^Λ, ι^Λι - -^ ^ ^ ^ ^ -ι ι--ι -^ ^ ^ rl f tf tf tf tf tf tf c cjcjc c cjcjcjcjcjcjcjcjoc cjcjcjoυυoυo Ha Ha H H Ha Ha Ha Ha a a a a a a ci a a a rl CN rl CM . . CM rt CM cj cj Ωtf ao tf acjΩΩ tftf aa ccjj ΩΩ fafaiifad] tftf a ccjj ΩΩ faCx]i dxii tf ωcj tf ac ΩP tftf aaccj ΩΩ ΩΩ fatii ωω ccoo oυoozυooυυosυoυozoozυυυυoooozυυυυooυozυυcouozuoυυυυozoυooυooυυ

N M 'ϊ in ω t^ co m o H N tη ^ ΛΦ ^ ωm o H N n 'r in ω r- ra ri O H cvi tn ^ in cD ^ cD W O H N to ^ in co ^ tn cri

CO OO OO ∞ CO CO OO OO Cn Cn cn cn cn cn cn cn cn cn O O O O O O O O O O rl rH H rl rH rH iH rl rH rl CM CN CM C CM CM CM CM CM CN CO OO OO n OO in in in in i in in in in in in i i i i in in in cD CD D co cD co co io cD o cD D co iD iD o cD io o cD io D io cD ^

H d H d d d d d H H H d d d d d d H H d d d d d d d d d d d d d d d d H H d d d d d H d d d d H d d d d d d d d d d d H d

00 rH

2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo o H tfHtf Etf^H Htf Etf^H Htf Htf Etf^H HtfEtfHtfH Et_fH Et_fH Et_fH Ht_f t_fH EtfH EtfH Et_fHtfH Et_fH Et_fH EtfHt_fH Et_fH Et_fH EtfH Et_fH HtfEt_fH EtfH Et_fHtfHtfH EtfH EtfH Et_fH EtfH EtfH EtfH Et_fH Et_fH Et_fH EtfH EtfH EtfH EtfH Et_fHt_fH Et_fH EtfH EtfH Et_fH Et_fHt_fH EH H EH EH EH EH O

Table 2

ATOM 1643 O PHE 1085 19. .846 35. .148 30. ,326 1. ,00 26. 28

ATOM 1644 N LEU 1086 19. ,377 32. ,952 30. ,563 1. ,00 28. 35

ATOM 1645 CA LEU 1086 18, .872 32. ,797 29. .212 1. ,00 25. ,31

ATOM 1646 CB LEU 1086 19, .145 31. ,385 28. .709 1. ,00 19. ,69

ATOM 1647 CG LEU 1086 20, ,649 31. .146 28. .547 1. .00 21. .64

ATOM 1648 CDl LEU 1086 20, .919 29. ,763 27. .995 1. .00 18. ,82

ATOM 1649 CD2 LEU 1086 21. ,227 32. ,215 27. .631 1. ,00 19. ,38

ATOM 1650 C LEU 1086 17. .391 33. ,073 29. .255 1. ,00 25. ,89

ATOM 1651 O LEU 1086 16. ,647 32. ,360 29. .925 1. ,00 25. ,83

ATOM 1652 N GLU 1087 16, ,974 34. .131 28. .562 1. .00 26. .76

ATOM 1653 CA GLU 1087 15, ,570 34. .511 28. .527 1. .00 28. .92

ATOM 1654 CB GLU 1087 15, ,428 36. ,039 28. .538 1. .00 28. .77

ATOM 1655 CG GLU 1087 13, .976 36. ,543 28. .523 1. .00 27. .49

ATOM 1656 CD GLU 1087 13. ,883 38. ,060 28. .352 1. ,00 29. ,97

ATOM 1657 OEl GLU 1087 14. .340 38. .573 27, .306 1. .00 30. .86

ATOM 1658 OE2 GLU 1087 13. .357 38. .747 29. ,261 1, .00 31. .30

ATOM 1659 C GLU 1087 14. ,879 33. .944 27, .292 1. .00 29. .76

ATOM 1660 O GLU 1087 15. ,336 34. .141 26, ,164 1. .00 30. .29

ATOM 1661 N ARG 1088 13. ,784 33. .227 27. .510 1. .00 29. .72

ATOM 1662 CA ARG 1088 13. .041 32. .667 26. .400 1, .00 31. .93

ATOM 1663 CB ARG 1088 13. .310 31. ,169 26, .238 1. .00 36. .51

ATOM 1664 CG ARG 1088 12. .700 30. .625 24. .947 1, ,00 43. .94

ATOM 1665 CD ARG 1088 12. .476 29. .112 24, .932 1. .00 46. .90

ATOM 1666 NE ARG 1088 11. ,471 28. .768 23, ,922 1. .00 52. .33

ATOM 1667 CZ ARG 1088 10. .807 27. .614 23, .867 1, ,00 54. .24

ATOM 1668 NH1 ARG 1088 11. .037 26. .664 24, .770 1, .00 53, .32

ATOM 1669 NH2 ARG 1088 9. .894 27, .421 22. .916 1. .00 52, .86

ATOM 1670 C ARG 1088 11. .547 32. ,876 26. .582 1. ,00 31, .39

ATOM 1671 O ARG 1088 10, .975 32, .525 27. .628 1. .00 31, .35

ATOM 1672 N LEU 1089 10, ,927 33, .467 25. .562 1. .00 28, ,47

ATOM 1673 CA LEU 1089 9. ,490 33, .706 25. ,564 1. .00 26, ,29

ATOM 1674 CB LEU 1089 9, ,145 34. .879 24. .641 1. .00 23, ,74

ATOM 1675 CG LEU 1089 7. ,675 35. ,197 24. .343 1. .00 21, .80

ATOM 1676 CDl LEU 1089 6. .774 34. .974 25, .559 1, .00 23, .10

ATOM 1677 CD2 LEU 1089 7. ,599 36. .636 23, .880 1, .00 23. .12

ATOM 1678 C LEU 1089 8. ,857 32. .423 25, .056 1. .00 25. .24

ATOM 1679 O LEU 1089 8, .916 32. .122 23 .870 1, .00 26, .06

ATOM 1680 N GLU 1090 8. ,262 31. .658 25, .961 1, .00 26, .17

ATOM 1681 CA GLU 1090 7. .656 30. .386 25 .592 1. .00 28, .55

ATOM 1682 CB GLU 1090 7. .358 29. .562 26, .850 1, .00 28, .73

ATOM 1683 CG GLU 1090 8. .535 29. .404 27, .824 1, .00 31, .24

ATOM 1684 CD GLU 1090 9. .790 28. .808 27, .186 1, .00 32, .62

ATOM 1685 OEl GLU 1090 9. .712 27. ,703 26, .609 1, .00 33. ,25

ATOM 1686 OE2 GLU 1090 10. .862 29. .450 27, .273 1, .00 34, .62

ATOM 1687 C GLU 1090 6. .379 30. .490 24, .754 1, .00 30, .27

ATOM 1688 0 GLU 1090 5. .722 31. .540 24 .672 1, .00 28, .66

ATOM 1689 N GLU 1091 6. .034 29. .368 24, .138 1, .00 29, .86

ATOM 1690 CA GLU 1091 4. .847 29. .289 23, .316 1, .00 30. .85

ATOM 1691 CB GLU 1091 4. .759 27. .895 22, .706 1, .00 36, .47

ATOM 1692 CG GLU 1091 6. .007 27. .536 21, .924 1, .00 44, .98

ATOM 1693 CD GLU 1091 6. .014 26. .099 21, .445 1, .00 49, .97

ATOM 1694 OEl GLU 1091 7. .041 25. .680 20, .859 1, .00 53, .36

ATOM 1695 OE2 GLU 1091 4. .998 25, .393 21, .654 1, .00 52. .79

ATOM 1696 C GLU 1091 3. ,603 29. .597 24, .145 1, .00 27, .67

ATOM 1697 O GLU 1091 2. .643 30. .181 23, .644 1, .00 26, .96

ATOM 1698 N ASN 1092 3. .631 29. .207 25 .413 1 .00 25, .03

ATOM 1699 CA ASN 1092 2. .514 29. ,447 26, .319 1, .00 23, .79

ATOM 1700 CB ASN 1092 2. .668 28. .611 27, .579 1 .00 22, .47

ATOM 1701 CG ASN 1092 3. .808 29. .092 28, .455 1, .00 24, .99

ATOM 1702 OD1 ASN 1092 4. ,676 29. .873 28. .021 1, .00 25, .87

ATOM 1703 ND2 ASN 1092 3. ,822 28. .625 29, .695 1, .00 21, .94 o "l^, ω CM CM oo oo dd cθ "tf cθ ιH o ^ co ^ o co r- c ro cM cn co ro rM r^ ι o oo oo rH n co r~ CM CM r^ ri crι oo θ ri σι rθ rH CM θθ θ ^ c c cM rθ "tf oo c ri cM oo r~ en ιn cM r~ ro oo o <» ι ^ oo cD CM rd ri oo o ιn cD σ^ cN o ιH D CN '^ cθ ri o oo o oo 'r ^ co ι o c c '^ oo ιn o ^ ιn σι cN in ιn cN ri t^ oo "tf Co σι cM CM C ιH ^ o ri ι θ H r-- cD H θ3 CM in ι r^ r-~ r^ lo t^ cD io i 'tf r r cN CN r^ i^ oo c o iH CM CN O iH CM C c co o o o c ro cn ri cN O ri iH c i rH o c^ cM CM CM CM CM CM CM cN CM CM CM CN CM CM ro ro ro n oo oo r oo cM CM co n oo cM CM CM co ro ro ro n cN ro co M n c^ rH cn co ιo σi "tf θ ro cM co o cD r~ σι o co cM Co co r^ ro ro ro cM cn o cM θθ oθ 'tf in o cD cn rH "tf 'tf θ ιn ιo co co cM in 'r cM n o ιn ∞

CM CM O ^ C0 «tf 00 l0 C0 ιn 00 C0 ιn θ ιn CN CM ιH rH O O Cn c0 rH 00 CN ιH «tf O C00000 C! rH - O "tf r-- r- rH CN 00 "tf O O rH O ιn σ^ r^ rH r^ co cM "tf CD rH CD r-~ r^ i o cM CM 'r _"tf Co cD r^ rH r-- r^ oo c rH r~ -^ oo ιn r «tf c oθ "tf ∞ θ ιH rH ro ro r 'r oo oθ 'tf r "tf CM o c C ro r i rH c CM ro cN co ro ιn cθ Lθ r-- C CN C^ ro ro oo ro r M Oo oo oo oo oo oo oo ro oo oo oo oo ro oo oo ro oo oo co ro oo oo oo ro oo oo oo ro cM CM CM Oo oo ro eo oo oo ro r^ oω tJi i^ αi n tη is' T o σi ffUD Mn mino ^ M HOΛ o i oN O o ^ m w Λt- ^ i N mo oo m in ino ^Λ o odoo M' too v H d oo r ιH ∞ ιH θ θ o r-- cD θ ιn (θ ro ro c» σD 'r < ι ι oθ 'tf CN ri ιn θ ιH r~ o σ cn σι ιo oo o rM [~ ro ro σι co θ "tf CM θ^

^■^ r^ ro e o r^ cD VD o oo o iD CD CM cn in ro ri 'r C O ri r^ C ^ cn ^ ^ cD 'r ∞ cD r c oo oD co c 'tf co o cN ∞

CN ιH ro oo cN ri o cN CNθ ro oo ^ ιn ^ ro ro cN CN !H rH θ co r-- t"- oo cn cn cn cn cn ∞

I rl rl rl rl H d d d d d d d d d d d d d d d d d d H d d d M

o o o o o o o o o o o o o o o o o o o o o o o o o o d d d d d d d d H d d H d H H d d H d d H d d d d d z z co co co co co co co co co a a a a a a a a a a a a z z z z z z z z a a a a a a cts a a a a ct; a a a a a a a c^χi fai c^χi fai (^χi c^χi fai fa] a a co o M i ri M M M M M ri x x x x x x x x co co co o co o co a a a a x x x x x x x x x x X Ha H Ha iH H Ha H Ha ia -i tf tf a a H EH H H H EH EH H EH H EH H tf tf tf tf tf tf tf tf EH H EH EH H H EH H EH EH EH EH EH EH H EH EH H EH M H M M rl M rl l CO CO

CM rl rl CN rl i-H CM CN rl C rl CM rl rl CN CM CM rl rl tf a CJ Ω p t]. J tf a o Ω txi Ω txi co a tf acjΩΩ tf acjo tf a cj Ω bi P Cxi co a tf a cj o Ω oozυoυυzυzυozυoυυoυoυoυo zooυozυozoυooυoz ooooooooooo o υ υ υ υ tf o υ z o

"f ιn oo r-* r--

00 rH se rH 2222222222222222222222222222222222222222222222222222222222222 rH ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo © EH EH EH EH EH EH EH EH H H EH H EH H EH EH EH EH H EH H EH EH H H EH EH H EH H EH EH H EH H H EH EH EH EH H H EH H EH EH H EH EH EH H H H EH H EH H EH H EH EH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

cD CM oo ιn ri oo cM M σ^ cN i ι cD "tf cr) io r-- r^ cn eD "tf θD "tf r~ 'tf r^ cD co ιn ri oo c cn >o oo oo ^ σ^ cn ro co oo oo oo θ "t_f in o co oo ιH in ri oo c co r_^ ι cN ^ θ ιH θ CM ιH θ oo cM o ιn r c CM rθ 'r ιn c 'tf oo oo c cD ro r~

© in ro r-~ in oo r~- in rO rH r~ ri <_o o ro iD cn o co ro in oo o oo cM CO o cM r 'r cM ri r~- o o r~- CN 'r co cN ro o r^ O CN CN C CN CN CN CN CN CN CN ro c ro o o rO 'T "t_f " ^ ro ^ rO 'j^, "tf in i in in tn 'r r "^ CΛ ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo υ rt rl rl rl rl rl 0. c Cθ ιH r- rθ ιH

CD CD 00 ι ιn ro cN CM ιH rH θo ccι oo co cM rH f c ιn ιn r^ r~ oo ^ o ^ 'tf CD r~ r^ r-~ oo oo 'r cM rH θ rH rH θ θ θ ιH CM CM CM ι^ oo oo oo oo co co oo cM CM CM CN co ro ro ro co oo oo oo ro oo M ro m co oo oo ro n co ro oo oo oo n ro oo cη oo oo o^ r-~ rH i i m [~- iD oo in cM "tf rO 'H p- M o oo o o in r iH CM r ri cD i oo in r^ o in o^ "tf CN O 'r c in r~ r-~ oo ro cθ "t_{f C}N i ιn o ∞ co cM io c C cn i oo 'j" co ιn ιn o oo o c r- c ι cN t_^ rH n ri θ _!^ c co ιn ^ co ιn c ιH o cθ rH Co σi [--- σ^ 'r r~ rM 'r α^ 'r ιn c co r~- oo c oo o co r cD co ιn cM θ "tf r cn "tf σ^ c^ oo oo cn cD θ θ rH CM rH ιH ro cn oo cn oo cn oo cn oo co r- cD r-. ιn ιn ιn cD '^ ιn co ιn "tf in ιn cD 'tf r ιH rH cn cn co

CM CM CM CN rO rO rO OO OO rO rO CM CM CN CN CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CN CN CM CM CM rH rH rH ^ o ^ H ιn n (^ 'r w o H t^ι O H c^l H ιn ^ ω ω o ιη ^ n tB v ^ (0 "l lJ H ι n o ι ιn ω ^ oo ( m ιη 'J^, ι l ιn H O t ^ ^ o^ ^• H Λ H "I' N ιn ∞ H o c^ι ^ ι "» N (l H Φ ^ m tn H o ιn oo ι N ιn ι n o H ^ ιn ^ ω ^ ιo >J ιn m ω n o fη tΛ m ^n <Jl ri N ω ιD H H O o^ o o H « J ^D ^ t-- co ^I! ^ N O (η o r^ r~ oθ "tf cη oo ro vD CN co ιn o c o co oo (N r r-- r~ ιn -~i' θ ιn cD θ ιn 'r i cn θ ιH CM CD o cn cM CM r^ c ri cN rH rH CN c r 'tf i co D "tf i 'tf io cD r-- oo c en ιn cD 'tf -tf M «tf i ιn D o cN CM ro cM CM C θ co r "tf ^

CN CN CN CN CN CM CN CN CN CN CN CN CN CN CN CM CN CN CM CM CN CM CN CM CM CN CN CN CM CN CN CN CN CN CM CM CN CN CM CN CM CN

cn cnen cno ooo o oo o o ri riri CM CM CM CM CN CM CM CM CM CM rO rO rO OO OO 'tf 'tf ^«tf"tf"tf"tf" 'tfLO-0-0LOL0-0L0-0L0 DCOlDC0lOCO σi cncn cno oo o ooo o oo o o OOOOOOO "O"O"O"O"O" O O O O O O O O O O O O O"OOOOOOOOOOOOOOOOOOOO

O O O O rl rl rl rl rl rl r rl rl rl rl rl rl rl rl rl rl rl i-H ddddddriddd ddddddddddddd a aoS acocococΛco cocococococo cococococococococococococo cococotf tf tf tf tf DDDDDDDDDcocococococococo M xi i xixx x xx x x x x x x x xx ri riri H MH H H H H H HaH Ha H Ha H H H HaH Ha Ha Hi x x x x x x x xx c c c co oco totnnna a a j a aaaa j ιiaaιJ aιiaa E Ea a EK Bsκ x ι< out3 i5i3uuut3 Hi HiιaajHijaHifl;<; fl;<;ι4; rt;

CM rl rl CM rl CM ao tf a cj Ω faico tf a CJ Ω ti co tf a cj Ω Ω fai fa] tf a tf a cj p txi cxi tf a cj Ω fai co tf a cj p p υoυozoooυυz oozυυoυυz υozυυυozυzυozυυo ozυoυυoooozυυooυzooz o υ υ o z

Lθ co r~ oo σ^ θ ιH CM rθ "tf in vo r'-- co cn o ri c Cθ ^,'r ιn co r~ CD C o ri cN r ^ ιo ιo ιo cD CD r r~- rr~rr^~rr--- rr-~~ tr~-- rr~-fr~-r"~ r-- αo co co ∞ oo co oo oo r~ r-r~ r~r~r~r~r-r~ r--r~r- r~ rH rl rl rl rl rl rl rl rl rl rl rl rl rl rt rl rl rl rl rH rl rl rH rl rl rH rl rl rH rl rH rl rH rl rl rH rl rl rH rl rl rH rl rl rl rH rl rl rH rl

00 rH

2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

© E tfH EtfH EtfH EtfH EtfH EtfH EtfH EtfH EtfH EtfH EtfH EtfH EtfH EtfH EtfH EtfH EtfH Et_fH Et_fH Et_fH Et_fHt_fEHt_fEHt_fEH EtfHtfH EtfH EtfH EtfH Et_fH EtfH EtfH Et_fH Htf Et_fHtfH EtfH EtfH EtfH EtfHtfEH EtfH EtfH HtfEtfH EtfH EtfHtfHtfEH EtfH EtfH EtfH EtfH EtfH EH EH EH EH EH EH H o

cn ιH CN in θ _'~r r--- ri ιn ro cn cn cD r~- ιθ Ln "tf ιH cn ιo r~- oo ro cn ιo o tn ro c^ r~- _ιH ro rM r~ ri c CD ri r-- c ιn θ ri ( "tf θ r-~ oo ιn rH ro oo oo co [~- σ^ σι o ι co o cD ^ σ^ r~ ιn ιn r^ ri r~ r_^ o r~ ιn ιn c _ιH r cM ( i rH in o oo (M θ r~ ι cD θ 'tf ri cM C Co σ^ θ "tf CN in ci r 'tf r-~ ri co ι^

"tf ^ 'tf o co r~ oo ∞ c r~ ∞ cn o o ιn ιn cD VD in «tf 'r o o cN C r^ co cD co r"'- co r^ ro ro ro oo oo ro oo oo ro oo ro o 't_f 't_f M ro oo oo ro ro oo oo ro oo oo ro ro ro e eo oo oo oo oo oo oθ "tf ^ '~r '~ι^, "tf «^

O rH cn r~ ^ [~- _ri co oo cn in ^ cD o cN OO O r~ in r~- oo cN p- CM rO ri oo oo oo o co cO iH in oo oo r-- ro cn

OO CM CM CM CM "tf r^ CO Cn CO "tf C30 -^ rH ιH ιH CD "tf CO O ιH ri e -^ ιn [^ 00000 "tf OO Cn 'tf "tf 3 r~ -^ CM

■t_f θ ' θ r _rH _ιH co _rH θo θ "t_f oo ιn co c 'tf θ CN Co c» o o co r c ι cΩ o cn "tf r "tf σ iθ ri r^ co cN r-- ∞ θ ιH M r θ _''r ιn ιn -^ 'r cN in c eN CN ^,'i^, r o r~ ιo r~ r-- θ "tf iθ 'r iθ "tf ∞ -- c^

CM CM CM CM CM CM CN CN CM CN CM CM CM CM CM CM CM CN CM CM CM CM CN CM CM CM CM CM rO t^ CO rO OO OO CM CM rO rO CM rO rO O^

OO rO CM r~- r~- CM (-o cn r~ r~- co cD rl rl rH

^φcor-M~M~ ι~ι^ r-r- r~ r~- r~ r~- r- co oo ∞ oo oo oo oo oo oo oo co cn cn cn cn oo cn cn o o o θ ri rH ri rl rl CM CM CN CM CM CM CM CM C OO OO OO OO OO OO o o o o o o o (-! (-> <-| |-| (-> |-| (-> l-ι r-) |-ι r-ι r-ι n O O O O O O O O O rl rl rH rl rl rl rl ddddrtHHdddddddddd dHdHHdddddddddddd

I rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl z z a a a a a a a a a a a a a a i ω ι] i i -i fa] fa] fa] fa] fa] H H Ha Ha Hi Hi H x x x x D D D D D D D D co c c co c co w c c co c c co c) co co co a a a a a a a a a ps a a a a a a a a a a a a a a a tf tf tf cji rtJ tf tf Ha i-a Ha Ha c-i ω cxi ω cxi fai cxi ω x x x x x x x x x x x x x x x tH EH tH h ri tH tH ri tt tH tH ⁽- oι tiι nt iiι ⁽iι iHiu i⁾ι Λ θι > > > > > > > um5 u a a ιi a a j a a j j aa a aa a a a H) ι a a Hi

CM CNrO rl i-HCNOO CM rl CM rl CM rl CM rl CM tf a cj Ω cxi xi Ω txi isi co a tf a CJ Ω Ω fal bl O tf a o CJ tf tf ΩΩ tf aoΩ faico tf a cj Ω co oo zoυoυυυυzυυooo O O O O O O O O O ozooυoυozooo υυυooo ozυυυoo zυ o z υ o o o υ ωr~ ω σι θ H N tθ "» ι w ω σι θ H N n "» ιn ifl ^ oo <Ji θ H ( π ^ ιn Φ flθ Λθ ri N (n ^ ιn ω ffl cιι θ H N to ^ ι ω ι~ ω ffιθ H N n * ι ω

CM CN CN CN co ro c r ro oo o o c rθ 'r "tf «tf "tf "tf "tf "tf ^,~r 'r ''r ιn ι ιn ιn Lθ i^ oo ∞ oo co oo ∞ ∞ oo co co co oo oo co oo co oo oo oo oo co ∞ oo oo oo oo co cD oo oo oo oo co co oo oo oo oo oo oo oo ∞ ∞ αo a oo ∞ d H d d d d ri d d d d H dH d d d d d dd d H d d d d d d d d H d d H d H H d d d d d d d d H dd d H d d d d d d d d d d

00 rH se 2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tftf tftftftf tftf tf tftf tf tf tf tf tftf tftf tf tf tf tftf tf

O

<N r~ .?> cM 't_f CD σ^ ^ r-- cn ^ co t~- 'r cθ 'r σι ι ιH ∞ o crι σ^ cN oo o ι rH σ^ H θ H i ι cM Cθ cN CD cτι D ι o oo cn H

% o cM ∞ ∞ ro oo ιH in oo ι o o o r ^ ιn co Λ 'tf co cM θ co iD CM 'tf CD D (M ∞ r cM in c ιθ rH o cD oo H co c c cD u^

,Q o 1 I cN ^ "t_f CD r~- oo oo o oo ιn cD ^ co r-- co o ri ιH 'tf CM CM in co ro oo cn cM cn cn cn cn o ri ri cn o o o cN co oo crι ^

© ^ (^ ro r c ro rθ ' co M c o r (^ cθ "tf "tf 'tf "tf -^ '~r 'r 'tf ^ι ^ ^ ιn 'tf "tf "tf 'tf tn ι ιn 'r ι ιn ιn ιn ι ιn L^

CΛ

? ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

U ftπ

C rθ rH θ in oo cD ^ rH CN 'r c o r θ ιH ''r cN θ "tf -o ro c ιn vD co 'tf r cn cN ιH _'^ r-- θ "tf r^

<Λ (η ^ o ^ o n (D W ι o ι c ^ 'ι^, ^ ^ (Il CΛO ( ^• H co ^I o ^ d ιn ^ N o ^ ιn m ^ (I\Φ o ^o ^^ ^ ■ϊ H m H N ιn oo o ιc) ιlO lJ^| "» ^ H ^ co o o ^ cn o c r~ ιo ιn "tf θ ι ( ιH co r^ rH 'tf CD ιn ιn o cM ri o cD in Ln o cθ "tf in σι r~- CD CM θ ιn co (η oo rH co r^

N ^ ω o o o^ o ωw ^ ^ ^ ^ oo co o o ^ ^o ^ ^ ^ a ω ^ ^ ^ n (η (ι l N π ^ι ^ ^ ιn ^o ^ ^ ^ ^c⁾ ^0 ( N t^ι o o ol O N O d ι o o d d ι 'j^, "^ "tf 'T 'tf in ιn 'tf in 'j^, 'tf "tf "tf 'r 'tf '^ 'r ~ι* Lθ 'tf '" 'tf ~t^, "tf ~J^l ~ϊⁱ ^ ^ "tf 'tf "tf 'tf ^,^ 'tf 'tf ^ 'r '^ ιn cD CD ^ co cD co ιn cj rH CD CN c r- D ro o ι r^ ι o cM i θ 'tf θ c cM θθ cn ιn co σι ιn o M "tf r^ c» ιn ι^ r-~ ιn r ιn o o cn c» r~ rH i o r rt rH CD r cM co ι ιn ιn c c cD oθ ri ι-o oo cD r-- crι ^ ^ cn ^ ιH θ '^ oo cM θ M r-~ ιH r~ oθ 'f θ "tf in r cM C cn cn iD "tf r~ oo "tf r^ ∞ c ιH CD ιH <_θ ιn o ιn c co o co r rH M θ θ o o ^

'tf cn o cn o cn cn cn r~- rH CM ιH CN CM cn rH o en cn o cn o o o cn ∞ oo cD r^ ιθ Lθ ιn co rN C^

CM CM CO CM OO CM O CM CN rO rO OO rO n OO rO OO CM CM rO CM CO m rO CM CN CM CM CM CM CM CM CM CM CM CN CM CN CM C^ cn -^ cn r~- rH Cn ri θ "tf C3θ "tf θ 'r "tf ro cM r-- rH iD 'r CD ro ιn ιn cN 'tf Cθ rH r~ cn ro ιn oo o cn o oθ ιH 'tf θ ιn ro o cθ "tf m ιn o ι^ o cM 'J^ι oθ ri c ιH r^ o ι co o ιn σ^ cD cn Ln r~- CM cn cn (η c r~- ιn σι oo cM "tf CD [~- 'tf cn co c co oθ 'tf in CD CD lD CD Ol rO CO 'r CD CD CM iH in -tf OO iH iH -^ O in OO CM ^ O rl O O a^ r^. lo CM rH r- CM CO Cn CM CO rH CO iH OO CN CM C^

■H CO CN 'tf ^,~r "tf CD r-- lO ιn in C0 r--.00 Cn 00 O O rl rt O CN r0 "tf CD 000000 CM rl rl O O ∞ '^^, "tf ^r^ι D co cD CD oo ∞ a o cD ιn r~ r- r- co r~ oo r- σ^ oo D co in 'tf oo rl rl rl rl rl rl rl rl CN rH rl rl rH rl

oo oo rθ 'tf 'tf 'tf "tf 'tf 'tf 'tf "tf in ιn ιn ιn cD io co co co iD r~ r^ r-- r~ [--- r-- co ∞ dHHddddddddHdHdddHddddddHddddddddHddddHdddHddddt l NNNC NMMt MCit M ddddddddddddddddddddddddddddddddddddddddddddddddddddddddddddd ddddddddddddddddddddddddddddddddddddddddddddddddddddddddddddd coco co z z z z z z z z xx x x aa aa a a cocoωcocococococococo co co co co cjocj cjcjcjoocjoo xx x xo oooooocjc c x x c c o o co coco c HaHa HaHa cxiω ciw ω ω x x x x x x x x x x x ^psa a os a a aaa a H i-a Ha Ha a a a a a a aa a H ι-a Ha tf tf tf tf tf tf tf tf j joc ococ cococoυ oυυ H H Ha H Ha Ha Ha Ha H tf tf tf tf tf tf ' tf ^J tf -tf ^Jtf ' tf ' ocjcjoa - c --i a - a - a - c -M atf ^• tf ^• tf Ω tf a CJ tf a υozυυ ozoooυυozoo r-~ oo cn o rH CM rθ "tf in cD r~- ∞ cn θ !H CN o "tf in ιo r-- co cn o ri cN θ '~n ιn co r~ co cn

∞ ∞ αo cn cn cn c c c cn e cn σ^ o o o o o o o o o O iH rH iH rH iH rH iH iH rH rH CN cN CM ON CN CN c^ oo cD ∞ oo ∞ co co oo ∞ oo oo oo oo oo cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn c^ d d H H d d d d d d H H d d d H H d d H H H d d d d d d d H d d d d d H d H ri d d d d H d d d d d d d H d ri d d d d d d H

00 rH se 2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

© E tfH EtfH EtfH Htf Et_fH HtfHtftfH Htf HtftfEHtfEH EtfH HtfHtf Htf EtfH HtfHtfHtf Htftf EtfH EtfH Htf Htf HtfEtfH HtftfEH Htf tfH EtfH Htf EtfH EtfHtfH EtfH Etf^H EtfH EtfH EtfH EtfH EtfHtfHtfH EtfH EtfH HtfHtf tfH EtfH Htf H H H H H H H H O

ι-~ ιH co oo c r~- cD CM ^ cD c ι ιn cM "tf CD r^ cD σ^ σι co r^ co cn r~ o r 'i^, co r^ ri o o θ rH ιH ιH r^ c^

Cn 00 ιH CD r~ 00 CM rH r~ 'tf ιn 00 00 C0 C0 l" rH O O Cn r~- ιH Cn cN in CD CN CO 00 (n 00 00 CD C0 O CO CN in 00 rH V0 '^ J

© o ιn ∞ o o cN c f~- cθ "tf θ ri o r~ ιn θ '~ι< oo cM CN in ιn ^ '~P '~r 'tf 'tf τi D c ri c ιH C Cθ ιH CM r~ ro c^ © ιo co co r~- r~- r- ' 'i^, -^ 'r _'~r "tf "tf "tf Lθ ιn Ln D io D D io ιn ιn ιn ιn ιn ιo ιo r~ ^

EΛ ooooooooooooooooooooooooooooooooooooooooooooooooσoooooooooooo

H ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo υ rH rl rl rl rl rl d d d d d d d d d d

P. o ∞ ιH "tf Co rθ 'T "tf Co oo ιo r-- m cn ' io co cn o ιo r-- ro ιn cn cθ "tf "tf cn oN in cM CD "tf ∞ r~ r^ ιn 'r cM D σ^ oo cn M ^ ιH oo ιn σ^ r-- o D o o r~- "tf θ ιH i rH CM C in Ln ιn ι o cM ^ σι CD oo ιn cD σ^ ro M

(Jιo o^ωι ιnιon^^otη^ooιBomιo^co»ιom(ηNm^HO oι ^(n(Iιmoπ^oo(η(nι tD(^ H ^ιooωo*^ωα)^Dιnn "tf ^ ιn ^ ιn o o cn co oo r~ σι r^ co o ιn co -^ "tf ro cM o 'tf -^ o cM o σι σ^ oo oo oo r~ cD c ri cN r '^ 'tf u^ ^■^ "tf ^ ^ ^ -~r "tf 'r ro ro oO (O ro n oo n oo r oo oo oo ro oo oo ro ro oo oo cM CM CM CM CM CM CM rO (^ oo ro oo o^

^ "tf ∞ co co ιn cN r-- ri r~- H cn co r~ r ιn o o ιn 'tf co ro co D o ^ r-- co ι^ cn r~ r~ rH cn r^ ro ιn r~- oo ιn r-~ 'r ro ιn σ r rH r~- co o ιH σ oo oo co r~ cn ri ιn ιn ι^ ιn co ιn oo oo o^ ro ι j o o cn c ιn cM CTι o>ι θ rH r-- cD ιH C3o σi D cM ^ σ^ ιn cM 'tf θ CM r-- CM r- cn ^ 'tf ^ ιn cD ^ rH O Cn Cθ r- CD ιH ιH CM CM "tf 'tf in CM ιH ιH ιH σ^ CD r-- cn cθ r~- ιH CN rH CM ιH CN e n ιH rH CN θ rM rθ ιH rH CM CN C^

"tf rH ' "tf co ιn ^ o ιn co cθ rH r^,~ θ !H cn 'tf co rH ^ r-- c cN c ∞ c r-- rθ ι→ ιH c o cN in r^ o ro cM r~- vD c co r-- D a o r cM ri oo r~ CM r M θ CD o co ^ oo cM CN r- oo o r ιH r CN CM cn "tf θ oo cn ιn rH ^ cn c "tf rH «tf CD ιH CΛ o r~- eθ "tf r~ r~- r^ 'tf CN cθ ri ιn ^,^ "tf θ ι ∞ r^ rH ^ co σ^ cM CD σι cM i cD o o ι c3Λ r^ ^ιnιnw^ιnnH(ηNn*t (^ιt HHOOO(Jlmoomooo!! σιΛω^ω^ωoo^-^oι '3'^β^B^(I)Oloωι ^o^ ^ CO o o o m m co r~ r rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rl rH rl rl rl rl rl rl rl rl rl I I

cMC CNC C CNCMCNcororoo o o o «tf _"tf

CN CN CM CM CN CN CN CN CN CN CN CN CN CN CN CN CN

HddHddddHHdHHHddd HdHdddddddddHddddHddddd ddddHHddddddddddd dddddHddddddddHdddHdddd o oo o cj ocjcj a a aa aaa cococococo co co co co co a a a a a a a a a a a a x x x x z z z z z z z z z co co co co co co co co co tf tf aa a a a a a a a a a ri H HH Hi Hi H ri M H X x x x x x x x x x x x Ha iH i-a ι-a iH Ha ι-a H Ha >-a H ι- r x x x x x x H Ha tf tf tf tf tf tf tf tf EH EH Eπ EH EH EH H a a a a a a EH EH EH EH EH EH EH EH EH EH EH EH j cj cj j o j o O i-a H Ha H Ha H H Ha H tf tf rl CM CN —r il —r jl rCvMi — r4t -rHl nCM.1 mC — i m o Ω fa] co a a tf a cj CJ tf a oΩΩ Cxi xi tf acj fai cxi o aα tf tf a c Ω a d tf a c Ω i to tf ozozzoo υ υ o υ υ o z ooυozυzυozooooooυooυ o z υυozυoυυozooz υυυυυzoozυ cθ ' in cD r~. co r- r^ d rl d d d d d d d H d d d d d d H H I N N t N N M tN N

222222222222222222222222222222 O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

Table 2

ATOM 2009 CB ALA 1129 7. 946 26. 817 40. 300 1. 00 31. 85

ATOM 2010 C ALA 1129 8. 212 28. 537 38. 501 1. 00 28. 04

ATOM 2011 O ALA 1129 8. 671 29. 614 38. 897 1. 00 24. 95

ATOM 2012 N ILE 1130 8. 548 27. 997 37. 331 1. 00 25. 55

ATOM 2013 CA ILE 1130 9. 512 28. 668 36. 460 1. 00 25. 84

ATOM 2014 CB ILE 1130 10. 408 27. 648 35. 730 1. 00 24. 07

ATOM 2015 CG2 ILE 1130 11. 103 26. 771 36. 743 1. 00 25. 87

ATOM 2016 CGI ILE 1130 9. 576 26. 785 34. 783 1. 00 22. 30

ATOM 2017 CDl ILE 1130 10. ,421 25. 886 33. 896 1. 00 18. 90

ATOM 2018 C ILE 1130 8. ,901 29. 619 35. ,417 1. ,00 25. ,23

ATOM 2019 0 ILE 1130 9. ,620 30. 188 34. 585 1. ,00 23. ,60

ATOM 2020 N LEU 1131 7. ,582 29. 796 35. ,474 1. ,00 22. ,59

ATOM 2021 CA LEU 1131 6. ,885 30. 672 34. 542 1. ,00 21. ,21

ATOM 2022 CB LEU 1131 5. ,493 30. ,115 34. 227 1. ,00 15. ,60

ATOM 2023 CG LEU 1131 5. ,505 28. ,801 33. ,432 1. ,00 11. ,10

ATOM 2024 CDl LEU 1131 4. .108 28. ,233 33. ,361 1. ,00 7. ,19

ATOM 2025 CD2 LEU 1131 6. 082 29. ,033 32. ,038 1. .00 4. ,00

ATOM 2026 C LEU 1131 6. ,774 32. ,086 35. ,086 1. .00 23. .55

ATOM 2027 O LEU 1131 6. ,251 32. ,309 36. ,191 1. .00 23. ,78

ATOM 2028 N PHE 1132 7. ,265 33. ,042 34. ,298 1. .00 23. .72

ATOM 2029 CA PHE 1132 7. ,249 34. .438 34, ,708 1, .00 24. ,86

ATOM 2030 CB PHE 1132 8. ,685 34. .916 34. ,968 1, ,00 28, .80

ATOM 2031 CG PHE 1132 9. ,291 34. .355 36. .229 1, .00 29, ,89

ATOM 2032 CDl PHE 1132 9. ,078 34. .978 37. .458 1, .00 29, .52

ATOM 2033 CD2 PHE 1132 10. ,028 33. .176 36. .193 1, ,00 30. .41

ATOM 2034 CE1 PHE 1132 9. .591 34, .429 38, .629 1, ,00 33. .18

ATOM 2035 CE2 PHE 1132 10. ,544 32. ,616 37, .364 1, .00 32. .28

ATOM 2036 CZ PHE 1132 10, .328 33. .240 38. .582 1, .00 32. .37

ATOM 2037 C PHE 1132 6, .577 35. ,341 33. .697 1, .00 24. .19

ATOM 2038 O PHE 1132 6, .553 35. .050 32. .505 1. .00 28. .10

ATOM 2039 N LEU 1133 6. .048 36. .451 34. .186 1. .00 22. .19

ATOM 2040 CA LEU 1133 5, .365 37, .404 33. .339 1. .00 20. .42

ATOM 2041 CB LEU 1133 3. .875 37. .313 33. ,627 1. .00 18, .98

ATOM 2042 CG LEU 1133 2. .869 37. .744 32. .573 1. .00 17, .32

ATOM 2043 CDl LEU 1133 3. .125 36. .981 31. .292 1. .00 17, .67

ATOM 2044 CD2 LEU 1133 1. ,458 37. .454 33. .091 1. .00 17, .57

ATOM 2045 C LEU 1133 5. .872 38, .816 33. .636 1. .00 21 .21

ATOM 2046 O LEU 1133 5. .916 39, .230 34. .790 1. .00 21 .22

ATOM 2047 N PRO 1134 6. .298 39, .558 32. .602 1 .00 22, .31

ATOM 2048 CD PRO 1134 6. .657 39, .079 31. .256 1 .00 21, .79

ATOM 2049 CA PRO 1134 6. .788 40, .928 32, .810 1 .00 21 .91

ATOM 2050 CB PRO 1134 7. .495 41, .248 31, .496 1 .00 22, .07

ATOM 2051 CG PRO 1134 7. .868 39, .892 30, .954 1 .00 20, .81

ATOM 2052 C PRO 1134 5, .603 41. .874 33, .046 1 .00 21, .75

ATOM 2053 O PRO 1134 4, .594 41, .786 32, .353 1 .00 22 .26

ATOM 2054 N LEU 1135 5, .710 42 .761 34, .028 1 .00 22 .32

ATOM 2055 CA LEU 1135 4. .632 43 .708 34, .297 1 .00 21 .76

ATOM 2056 CB LEU 1135 3. .785 43, .304 35, .512 1 .00 17 .50

ATOM 2057 CG LEU 1135 2, .990 41, .993 35, .546 1 .00 14 .52

ATOM 2058 CDl LEU 1135 1. .923 42 .095 36 .624 1 .00 4 .60

ATOM 2059 CD2 LEU 1135 2, .341 41, .732 34 .208 1 .00 10 .88

ATOM 2060 C LEU 1135 5 .198 45. .072 34, .571 1 .00 23 .53

ATOM 2061 O LEU 1135 6, .331 45, .199 35, .037 1 .00 24 .94

ATOM 2062 N PRO 1136 4, .419 46 .121 34, .262 1 .00 27 .53

ATOM 2063 CD PRO 1136 3, .196 46 .068 33, .441 1 .00 26 .33

ATOM 2064 CA PRO 1136 4, .822 47 .515 34, .482 1 .00 28 .25

ATOM 2065 CB PRO 1136 3, .726 48 .305 33, .770 1 .00 27 .06

ATOM 2066 CG PRO 1136 3, .281 47 .370 32 .695 1 .00 26 .26

ATOM 2067 C PRO 1136 4, .805 47 .742 35, .993 1 .00 28 .67

ATOM 2068 O PRO 1136 4, .103 47 .039 36, .720 1 .00 30 .06

ATOM 2069 N VAL 1137 5, .560 48 .713 36, .480 1 .00 29 .29 OOOOOOOOOOOOOOO OOOOOOOOOOOOOOO cD cn r~- fO

o co cn

(I) ln ιη N(η lO 'tf n ιn co iD o cn

r r r^ r- r-- r oo oo oo oooo r~ r-~ r~ r~ r~ r~ r r- co oo oo ∞cocn cncn cncncn cncno o oo o o rocoro rooooooorororocθ 'tf '* "tf 'tf 'tf 'tf 'tf 'r 'tf -r "tf "tf "tf "tf 'tf «tf 'tf 'tf 'r "tf "^ d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d rH iH rH i→ rH iH iH iH iH iH i→ CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CN CM CN CM CM CM CM CM CM CN CN CN CM CM CM CM CM C^

JJJ μlιi acι: (l!l)5κ;(<;ZZ 222222 t3e)t5O0H hhHH Hrih0O0000 _ θ - a.. Ha Haπ HiHa H tf tf tf tf oooooooaaa tf tf tf tf tf tf fai xi cxi icxic cococo o oc a a a a ω citxi xicxi txi cxicxi a a aa αios tf tf tf tf tf tf tf r - πa - H - πaacsaaaaaxxx >> > > > >cococococotf tf tf tf tf tf tf tf tf tf tf tf tf 22222222a a a aaaa>> > > > > > tf tf tf tf aaaaaaaHEHEH rl CM rl CM rl CM tf aoc tf a o Ω tf a tf m CJ Ω J Ωtf acj tf acjcj tf a Ωtf ao tf a υυoooozυoooυooz o o z o o o o z ooυcoυooz oυυυoozυυυυoozυuυozυυoυυozυυ

O ι

O rl CN

00

2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H EH EH EH EH EH EH EH EH EH EH EH H EH EH EH EH EH EH H EH H H EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH H EH EH EH EH EH EH EH EH EH EH EH EH EH EH t_f tf tf t_ft_f tf tftftftf tftf tf tftf t_f tf tf t_ftf tf t_f tf tf tf t_f t_f t_f t_f t_ft_f t_f t_f t_f t_ft_ftftf tftf tftf tftf tf tf tf tf t_ft_f t_ft_ftftf

O

Table 2

ATOM 2131 CG TYR 2154 10. 926 94. 732 7. 678 1. 00 16. 22

ATOM 2132 CDl TYR 2154 12. 161 95. 274 8. 011 1. 00 14. 25

ATOM 2133 CE1 TYR 2154 13. 087 95. 600 7. 029 1. 00 17. 02

ATOM 2134 CD2 TYR 2154 10. 638 94. 521 6. 332 1. 00 17. 27

ATOM 2135 CE2 TYR 2154 11. 559 94. 842 5. 340 1. 00 14. 79

ATOM 2136 CZ TYR 2154 12. 776 95. 383 5. 696 1. 00 15. 43

ATOM 2137 OH TYR 2154 13. 676 95. 728 4. 723 1. 00 16. 67

ATOM 2138 C TYR 2154 10. .571 91. 995 8. ,711 1. 00 22. 61

ATOM 2139 O TYR 2154 11. ,657 91. 687 8. ,203 1. ,00 23. 08

ATOM 2140 N TRP 2155 9. ,452 91. 316 8. ,502 1. 00 24. 53

ATOM 2141 CA TRP 2155 9. ,404 90. 115 7. 677 1. 00 25. 22

ATOM 2142 CB TRP 2155 8. ,017 89. 493 7. 786 1. ,00 20. ,66

ATOM 2143 CG TRP 2155 7. ,600 89. 146 9. 194 1. ,00 16. ,41

ATOM 2144 CD2 TRP 2155 8. ,402 88. 535 10. 208 1. ,00 12. ,68

ATOM 2145 CE2 TRP 2155 7. .571 88. ,351 11. ,344 1. .00 14. ,74

ATOM 2146 CE3 TRP 2155 9. .737 88. ,123 10. .273 1. ,00 13. .09

ATOM 2147 CDl TRP 2155 6. .352 89. ,305 9. .741 1. .00 18. .18

ATOM 2148 NE1 TRP 2155 6. ,328 88. ,829 11. ,029 1. .00 14. .03

ATOM 2149 CZ2 TRP 2155 8. ,040 87. ,769 12. ,532 1. .00 11. ,48

ATOM 2150 CZ3 TRP 2155 10. ,203 87. ,541 11. ,459 1. .00 12. ,94

ATOM 2151 CH2 TRP 2155 9. ,353 87. ,373 12. ,569 1. ,00 14. ,66

ATOM 2152 C TRP 2155 9. .722 90. .419 6. ,210 1. .00 27. .64

ATOM 2153 O TRP 2155 9. ,326 91. .454 5. ,679 1. .00 27, .23

ATOM 2154 N THR 2156 10. ,433 89. .503 5. ,560 1, ,00 30. .07

ATOM 2155 CA THR 2156 10. ,810 89. .663 4. ,162 1. .00 32. .68

ATOM 2156 CB THR 2156 12, ,334 89. .496 3. ,996 1. .00 33. .62

ATOM 2157 OG1 THR 2156 12, ,998 90. .564 4. ,675 1. .00 36. .23

ATOM 2158 CG2 THR 2156 12. ,737 89, .532 2. .531 1. ,00 40, ,06

ATOM 2159 C THR 2156 10. ,083 88, .642 3. .289 1. .00 34, .34

ATOM 2160 0 THR 2156 10. ,241 88. .617 2, .069 1, .00 34, .49

ATOM 2161 N SER 2157 9. ,272 87. .803 3. .918 1, ,00 35. .53

ATOM 2162 CA SER 2157 8. ,542 86. .788 3, .181 1. ,00 36. .03

ATOM 2163 CB SER 2157 9. .490 85. .632 2. .860 1. ,00 37. .70

ATOM 2164 OG SER 2157 8. ,833 84. .616 2. .133 1, .00 43. .05

ATOM 2165 C SER 2157 7. ,375 86, .303 4, .026 1. .00 36. .23

ATOM 2166 O SER 2157 7. .117 85, .106 4. ,120 1. .00 36, .84

ATOM 2167 N PRO 2158 6. .639 87, .242 4. .639 1. .00 36, .88

ATOM 2168 CD PRO 2158 6. .668 88, .673 4. .292 1. .00 35, .23

ATOM 2169 CA PRO 2158 5. .487 86, .950 5. .498 1. .00 37. .16

ATOM 2170 CB PRO 2158 4. .713 88. .262 5, .489 1. .00 36. .26

ATOM 2171 CG PRO. 2158 5. .790 89, .271 5. .347 1, .00 36, .76

ATOM 2172 C PRO 2158 4, .653 85, .793 4. .985 1, .00 38, .08

ATOM 2173 O PRO 2158 4, .120 84, .997 5, .759 1, .00 37, .13

ATOM 2174 N ALA 2159 4, .536 85, .721 3. .666 1, .00 40, .74

ATOM 2175 CA ALA 2159 3, .771 84, .669 3. .020 1, .00 41, .35

ATOM 2176 CB ALA 2159 3. .976 84, .737 1. .512 1, .00 42, .33

ATOM 2177 C ALA 2159 4, .214 83, .310 3. .549 1, .00 41, .99

ATOM 2178 O ALA 2159 3 .465 82 .636 4, .271 1 .00 41 .46

ATOM 2179 N ALA 2160 5, .439 82, .922 3, .196 1, .00 40 .06

ATOM 2180 CA ALA 2160 5, .992 81, .640 3, .615 1, .00 41 .70

ATOM 2181 CB ALA 2160 7, .505 81, .629 3, .395 1, .00 40, .83

ATOM 2182 C ALA 2160 5, .670 81, .281 5, .072 1, .00 42, .86

ATOM 2183 O ALA 2160 5, .556 80, .101 5, .418 1, .00 45, .81

ATOM 2184 N MET 2161 5 .505 82 .292 5 .919 1 .00 41 .09

ATOM 2185 CA MET 2161 5 .223 82 .062 7 .335 1 .00 36 .97

ATOM 2186 CB MET 2161 5 .658 83 .287 8 .152 1 .00 35 .45

ATOM 2187 CG MET 2161 7 .028 83 .838 7 .748 1 .00 33 .71

ATOM 2188 SD MET 2161 7 .574 85, .241 8, .737 1 .00 28 .89

ATOM 2189 CE MET 2161 9, .301 85, .166 8, .486 1, .00 33 .50

ATOM 2190 C MET 2161 3. .765 81, .725 7, .653 1, .00 35, .46

ATOM 2191 O MET 2161 3, .456 81 .336 8, .775 1 .00 33 .94 cricn o ooo ro cM oo cM o)'i^, ιooσi "r"f or-

oooooooooooooooo oooooooooooooooo Hddd dddddddHHHdd oωH mwo^DO"l'"l'H cnoo ooo σι ooo θ riσι rθ ri o tnoo ιcoo ooιηwrn^ηN

CM CN CN co cN θθ ro oo oo r oo oo oo rθ "tf "tf 'tf '^ 'r ιn ιn ιn ιn ιn ιn Lθ L io co ιo co cΩ io co c^

CD CO CD CD VO ID CD O CD CD CD CO CO VD CD CD ^ CD CO ID CO IO CD CD 'JD VD CO CD CO ID CD CD I^ CD CD VO IO CD CD CO VO CO CD IO CD C^ d rt d d d d d d H d d H d d d d H d d d d d d d d d d d d d H H d d d d H d H d d d d d d H d d d d d d d d d H d H d H d CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CN CM C^ tf tf co co cococo co cococo tf tf tf tf tf DDθDD DDDcoco o c coaco ococotf tf tf tf tf HaH ι- ι-aH H ι-aoooooo o Ha pi x x x x x πa - i raHa i-a faifaicxi cxi xi ω dfai HH H iH HM H μH H Ha H Ha i-a H tf tf tf tf tf tf tf os a aa o a a rt rtU HlHl HlHl Hl^j HaH S tf tf tf tf H HaH H Ha H H Hiaaaa tf tf fttf tf >>> >> > >a aaaaac tf rl tf5 tf^ tfr1 rl CN CM rl rl CM rl CM tf a tf a cj Ω xi co tf a tf a cj Ω Ω υυoozυυoυυzυo t flυf C z υo υ oz υυυυυυo zfυ υJ ΩυΩzCυxl Czxlooz tfomυυ tf acjcj Ωtf ao tf a zooooυozυυυυυozυυ υ

ιH θθ ιH CN 'tf r~- cn σι ntMω'»ι σlιnoo o^ o ιnod'»(^( (^ι rH θ c3i cM CM CMc ιn 'f "tf c»oo ∞ io co in co cD ocD r- NO H in cncncn cn r rHi rH "tf ri ro ro ro

d C C CM CM CM ro o o r r ^ 'tf 'tf 'tf -^ 'r 'tf in in in in in co D CD co D co co cD CD CD CD r^ r-- r~ r-~ r~ r~ r-- r~ r~ r^ r~ r- r~ r- r~ r^ r~ r~ r~ d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d CM CM CM CM CM CM CN CN CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CN CN CM CM CM CN CM CM CM CM CM CM CM CN CM CM CM CM C^ tf tf tf tf tf tf tf tf tf tf a a a a aa a iH HaH Hi H iH Hatf tf tf tf tf ω w a -iωωci fai ω cxifai tf oa a faa coi f a d CM d CM d CM d CN z o t o υ o z tf a tf a cj cj tf a CJ tfa tfaoΩΩfaiwco f a cj υ υ υ o z υ υ o υ υ o z υ o υ υ υ o z υυυozυoυoooooo tf a tf a cj Ω t tf a o z o υ o o z υ υ oocozoυoυυ o z υ υ r '* tn ιo r~- co cn o < ro -'r ιn co r~ cD cn o C r 'tf in co r co cn o cN c "tf ι^ Lθ in ιn ιn ιn ιn ιn co cD co vo ιo cD co co cD CD r- r~- r-- r~- r~ r~ r--- r-- r^

CN CM CN CM CM CN CM CM CN CN CN CM CN CN CM CM CM CN CN CN CM CN CM CN CN CN CN CN CM CM CN CN CM CM C^ CN CN CN CN CN CN CN CM CM CN CN CN CN CN CN CN CN CN CN CN CN CM CM CN CN CN CN CM CM CN CN CN CM C^

00 rH se 2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

© tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf O

oo ro oo oo

∞ o rø 'tf d r r^ o co r^ c ∞ 'tf CN r^ in cN r^ d co ∞ oo cD 'tf CNi ^ 'tf O r r^ C 'tf ιc o N ^ ^ ω co « ιn N H O O d c^ι t^ ^O N ^ o o w ι ι d ω ^l ^ (^ι lD l» ^ ^ ( ^ ^ ol ι» Φ ^ <ιf ^ ^ ^ ι tn co 0 ^o o ιn ι m α) ^ (» cD θD in -- θ 'tf u Ln r-- ιn r in cn cD σi 'tf r~. o cN ro σ> Ln cN cn cM o r~- o cM oo ιn cM r^ co c o c^ cn r-- r~- r~ r~- co ιn oo cn co cn cn σι o o o oo σι co r~ o ιn ro •^ CM "tf σι cN i co o o cM 'r (η cM in r-- ι o cD θ '~r σι r~ ιn c "tf θ CM "tf Co cD θ CD oo ιn oo r-- ^ιι ^ι D r- r- CN co r~ co o oθ "tf r- cD "tf in o oo o cn d rroo dd oo rroo oo oo oo dd eσn^ -ⁱtftf ^^ oo ccMM rr~~-- ccNN rroo ccMM ccnn ιιnn ccDD oooo rroo ccDD oooo rr---- ιιnn oo oooo rr-- ιιnn ""tftf oo ιn cD cD o ιn oo oo d oo iD d -tf N 'tf c oo cM r- iD c CM co in in d o^ cD in D r-~ M in in o r oo oo cD r--. r oo O 'r r o in d 'tf r cM CD ^j" ro c d C CM co CM co co r- o cM oo -tf CD o in tn ro cD ou O W H N tn tn c t ^ Λ io in t^ m m o ω ω m co oi i^ ra oo w w i ^ n N H M n n cif n t tN N O o o m ai tJi ω ω oo ^ oo cn co cn cn cn cn cn cn cn cn cn cn cn cn cyi o c^ cn cn cn cn cn cn en cn cn σ^ σi σi cn cΛ cn cn cn σi σi cn σ^

"tf θ ∞ cN

H m to d r~ co cn cD

"tf in 'r d d d

o o o d CN cN C CN ro o o o o ro oO '^ ' 'tf 'r 'tf -tf ^ in in in in in in in in cD io io io i^

OO OO CD OO TO OO OO OO ∞ CO OO OO OD CD CO OO αO CO CO OO OO OO CO CO CO OO CO CO OO OO CO OO CO OO OO CO OO CO OO OO OO OO CO OO CO ∞ d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d

CN CM CN OM CM CM CM CM CM CM CN CN CN CN CN CN CN CN CM CN CN CN CM CN CN CN CN CN CM CM CN CN CM CN CN CN CM CM

"tf in o r~ oo cn o d cM ro -~r ιn cD r~ co c o d CM θ 'tf in co r-- oo cn o CM rθ 'tf in D r~ 3 CΛ θ CN fθ '^ ιn d d d d CM CM CN CN C CM C CM CM CM ro r ro o oo oo r r rθ 'r "tf 'tf '^ 'tf ^,^ "tf -^ -^ ^ ιn ιn ιn ιn ιn ιn ιn ιn Ln ιn o ιo ι^ oo oo oo oo oo oo oo oo ro ro ro ro oo oo ro oo ro ro ro oo oo ro oo oo m ro co oo oo ro ro oo ro ro oo n n m

CM CM CM CM CM CM CM CN CM CN CN CM CM CM CM CM CM CM CN CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

00 rH ^O 2222222222222222222222222222222222222222222222222222222222222 rH ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo © tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

ooooooooo ooooooooo d d d d d d d d d ιo ιoω d O(B

CM r-~ r-- d

ιn oo cM θ c r inCD

lOOOOooooooooo o dd ra cn cn cn cn cn cn cn cn cncncn cn cn cn cncn d d d d d d d d d d d d d d d d d CN CN CM CM CM CM CN CM CM CN CN CN CN CN CN CM CN tf aaaaaacMaaaaaaaDDDDDDDDcococococococococozzzzzzzzxxxxtf tf tf tf tf tf tf tf tf [x] fa] fa] b] fa] fa] fa] H aaa aaapsaaaaaaiifaifaifaiωfaiωω xx xxxxxc ocococ c co oHaHaHai-aH HaHaH H HaH Ha H-i a a a a a a a tf HEHHEHHHHEHEHEHEHEHHEπiHiHH H H HaHaHaH H H HiH^HaHaH^i^tf tf tf tf tf tf tf tf oocj tf tf tf tf tf tf tf tf tf C CM eu a u M -i

C CNM C INN O l^τO) d rl d rl C CMM O I'OJ C CMM l IN n I d CM d tf xicxiΩw o a tf ac ΩΩ tf aoΩfaico tf oΩΩ tf tf a tf a tf a J Ω Ω a

O Z ooυυouυzυυυυozυoυυooozooooυzυozυυυozυozoυozυυυozυυυ ozυooooυ ιn cD r-- oo cn o CM ^ ιn co r~ ∞ cn o CM (θ -^ ι D i~- c» 3θθ d cM ( "tf in co r-- oo o o CM rθ "tf in co t~- ∞

^ ^ ^ ^ ^ 0 ω l C0 ω il0 IB 03 C0 tD 01 1 ^ 010>0l (n Φ (Λ (Jl OO O O O O O Q O O H d d d d d d d d d N N N C N N M N ( (\| l^,) l^,) nfi miη co co oo oo oo ro oo oo co oo ro ro ro oo co i^ oo ro oo oo oo ro oo co ro ^ 'tf 'tf 'tf 'tf 'tf ^ ^ ^ '^

CN CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CN CN CM CM CM CN CN CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM C^

00 rH

2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

EH EH EH EH H EH H EH EH EH EH EH EH EH EH H EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

ιn oo tΛ ιI)mo tIo o d "|ι oooooooooooo oooooooooooo

(η ^ Λ ^ ι lI) ^ ^ n ιn ^ o ol ^ ιn o oo ω ^ ^ H o n cD H N H ω ιn ιΛ l d C ^ ιn ιn ιn ^ ιn ^ι ιn "^^, r O t3l Λ ^ H lJo ^ ιn ι ^ tη ι»l N in cM θ^ o cn 'τ o oo cM c» D 'tf D 'tf cn cM co cM -tf o r-- c Λ r-- o ιn ιn r r~ cD ^ o r ιn ι cM (M ∞ cM θ co r

■tf o r~- r~ ιn -θ t co ιn cN r-- cn r~ ιn o r~ o r~ 'tf ' ∞ cn ™ θ M H n n ^ N N ri o m o H H M n "» "i n ι ^ ^ m <j <» ιn ι ^ co a (η ^ N d θ m co oo w » a H θ o o θ Λ H tD oj w ιo a ^ oo ^ >o

CN CM CM CM CM CM CM CM CM CM CM CM d CM CM CM CM CM CM CN CM CM CN CM CN CN CM CN CM CM CM CM CM CM CN CM CM d d d d d d CM CM CM CM N r~- oo o oo ιn ιn

N (3l O O d o r- oo iO 'tf CM

CM CM CD iD ιn ιn ιn oo cM θθ 'τ cN CN ro d θ d o θ d d CM cn co o o d CM ro cM c "tf cn co oo r~- co co cn r~ r~ r-~ cD io ^ r~ r^ ι^ r^ ι^ r-- t^ r^ r-- ι^ r-- r"-- r-- [-~- c^ r~ r-- r-- ι-~ c c c co ro ιn ι oo r o cM 'tf d r-- ro cM θ ro o cD o r~- "tf c σ^ o CD ιn r oθ "tf CM in 'tf σ^ ιn cn r-. oo r~' (»

^ ιo fπ ^ O d N (η w ^ ιD co ^ o o ^ ^ n o ol ^ o cD ^ ιn o o ^ » (Λ c^ tη o ^ Φ ι (Jl ιo ι3l t oo d H lfi H 9 ι^r) ιn >3^, ^D ι ^C! t\l - O H O ^ o ^) o co co d in σ^ ro d "tf co ro ro ιn co ιn r-- ro d n o d cn d cn ∞ cn >o r ∞ cn o cn co o cn ι^ ιn ι cD (Iι <- O o <Λ d l N n H H c^ι ^l m "l^| l» "l^ι o o m m ^ ^ ιo w (D ^ ra w ω (D ^ w ^ ^fl ^o ffι o ffι o m o o x o ιIl d d d l d d o tJ^ d d d d d CN CN CM d CN CM CM CM CM CM CN CN CM CM CM CM CM CM CN d d d d d d d d d d d d d d d d d d d d CM d CM d CM d d CM d CM CM CM CM CM CM CM d

r- r~- r~ ι^ oo oo oo oo oo oo σ^ c^ c cn rι c3θ o o o o o o o θ d d d d d M CM C CM C C CM CM C CM C ro r o r o M tn cn cn en cn cn cn σi cn cri σi cn cn σi cn cn o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o d d d d d d d d d d d d d d d d CN CM CM CM CM CM CM CN CM CM CM CM CM CM I CM CN CM CN CM CN CN CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ CN CN CN CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CN CM CN CN CM C^ fa aiωafifaitf_πitf_H ft_Ha tf_Hi tf_H oaoo oa oaoaoa oa aco ac aa cao aaacocaocaoc_Moc_Moci-o_Hω_Hc_Hoc_How_ric_Moc_Moc_Moo o ooooo o fai cxi cxi ω faicxiωcxixx x x x x x x a - a--a-- p-s-a a . a. a.a ^■ os - PS. ι-a - H - H - H - Ha - ι- - ι- - H - Ha - H - H - ι-a - H - ι-a - Ha - ι- aaaatftftftftfaaaaaaatftftftftftftftfaaaaaaaaaa tf tf tf tf tf tf tf tf tf tf tf M M H H M M M M CJ O CJ CJ O CJ O CJ

CN d CM CM d d CM d CN CN d d faico tf a Ωtf acj tf acjΩΩ tf aoΩ Ωtxicxi tf acjΩwcoaa tf a CJ CJ Ω tf tf oυoo zυooozυυυυoo zoυoo o υo υoυozozυozooυυzozz υozυυυυυυozυυozoυo ιo r~ ∞cn od CN oθ 'tf tn cD r~ ∞cn o d CNrθ 'tf in co r-- cocno d CN rθ "tf incor ∞ r oo o _"tf -~^ι 'tf 'tf 'r '_tf 'r "t_f -^ ^ι-θ LnLn ιn ιnιn tn ιnιnιn ovo o cDco D C_D CD CDCD r~- r-- r~ r~. r_^

^ * ^ * ^^ ^^ ^3 ^ * ^3* ^^ *ζjt ^j* ^3^ ^3 *^P "^T ^ * ^3* ^3* ^3* ^ *

CM CM CM CM CM CM CM CM CM CM CM CM CM CN CN CM CM CM CM CM CM CM CM CM CM CM CN CM CM CN CM CM CM CM CM CM CM CM CM CN CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM

SO

2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

EH H H H EH H EH H H H EH EH EH EH EH EH EH H H EH H H EH EH H H H H H H EH EH H H EH H EH EH H EH H EH H EH H EH H H IH H H H EH EH H EH EH EH EH H EH

© tf tf tf tf tf tftf tf tf tftftf tf tf tf tf tf tftf tf tf tf tftftf tftf tftf tftf tf tf tf tf tf tf tf tf tf tf tftf tf tf tf tf tf tf tf tf tf o

θ r~ r^ ^ r~ -θ cn oιθ "tf CM i^ ro ιn io ιooθ -θ r^ ιn c r-~ r^ co r "tf

_CNro cnιo c_M ∞ doo d 'tf CN cn d oo oo r~ o ιn cri "tf CN θ co oo cn cn cDcn rocM cn o ro tnco co m

"^ "tf c cn inr r r~ LO cn o io o r~- r~ co r-~ ,^ r-- .^ cn ro in o r~ d r- co c cDin ιncD CDr- oo oo oo ^ "tf inooro d C CM CM CM ro ro -~r d d θ OT r~ σι ooco crιo cM CN ro r 'tf 'tf in oo oo ^ d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d cncNrocM oor co d r~- cτιco cM θ co o o cnr~ cN CNθ ro cD o cn o cocN CN ∞ oo _'tf cnιncn cocn o∞ co r- "tf ri o∞ 'tf o σιr~- ιn ι ∞ σι CD oo r^ c i~- r~. cM r- σι ooιn r co ρ~ [^ cn ^ cD Dθθ ιn ι^ ∞ o∞roιn oooor "tf CD r~- o r~- CM ro σι ιn 'tf r_^ cn cn d d r^ cM r_^ 'tf røcn ror~ doo d d _'^ tnoo oo d oo oo ro σi 'tf d d CM C "tf in ro «tf in co oo oo oθ "tf θ ιn ιn cor^ oo o ∞ ∞cn cocn coo d d ro ro ro cN d oo cM d d M -w oooo oooθ "tf CM CM θo o c^

mn d d aaosaaosaaaaosatf tf tftf _M HI πa π πa rl rl tf tf itf tf tftf aaaaaaac C aaαjC C C-r

X X X X X X X X X X J iH H H tf tf tf tf tf tf tf Haπ H EH EH tH EH EH EH EH EH fH EH EH tf tf tf tf >>>>> >> H H f Ha tfHtf aHaaH EH a tf tf tf Jt EH EH EHaH EHaHaEH EaHaHaEHaEH d d CN CM d CM d d CN CM d CN CN CM 00 d tf a cj Ω Cxi Ω fai co a tf a tf a cj cj tf a tf acjΩ fai Ωfaicoa tf a tf a cj cj tf CJ Ω fa] fa] Ω zυoυυooooooozυooozoυυυoozυoυo zooυυoooυooozυυυozυυoυo zυυoυυυυ

CM 22222222222222222222222222222 OOOOOOOOOOOOOOOOOOOOOOOOOOOOO tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tftf tftftf tf tf tf

Table 2

ATOM 2558 NE1 TRP 2213 17. ,770 87. .311 7. .132 1. .00 29. ,13

ATOM 2559 CZ2 TRP 2213 18. ,357 88. .764 9. .093 1. .00 31. ,44

ATOM 2560 CZ3 TRP 2213 17. .581 87. .839 11. .194 1. ,00 30. ,07

ATOM 2561 CH2 TRP 2213 18. .238 88. .841 10. .458 1. ,00 31. .81

ATOM 2562 C TRP 2213 16. .287 81. .961 9. .264 1, .00 24. .83

ATOM 2563 O TRP 2213 15. .090 81. .961 9, .551 1. .00 22, .52

ATOM 2564 N SER 2214 17. .020 80. .861 9, .302 1, ,00 27, .35

ATOM 2565 CA SER 2214 16. .394 79. .591 9. .642 1. .00 29, .71

ATOM 2566 CB SER 2214 16. .088 78. .819 8. .354 1. ,00 27. .02

ATOM 2567 OG SER 2214 17. .209 78. .851 7. .494 1. ,00 27. .71

ATOM 2568 C SER 2214 17. .195 78. ,710 10. .601 1. ,00 28, .94

ATOM 2569 O SER 2214 18. .374 78, ,960 10. ,877 1, ,00 28, .56

ATOM 2570 N ILE 2215 16. .514 77. ,698 11. ,127 1, ,00 27, ,21

ATOM 2571 CA ILE 2215 17. .106 76. ,732 12, ,040 1. .00 28, .54

ATOM 2572 CB ILE 2215 16. .427 76. ,730 13. ,419 1. .00 27. .61

ATOM 2573 CG2 ILE 2215 14. .908 76. ,803 13. ,260 1. .00 26. .81

ATOM 2574 CGI ILE 2215 16. .844 75. ,461 14. ,172 1. .00 27. .42

ATOM 2575 CDl ILE 2215 16. ,230 75. ,302 15. ,532 1. ,00 26. .34

ATOM 2576 C ILE 2215 16. .891 75. .362 11. ,410 1. .00 29. ,14

ATOM 2577 O ILE 2215 15. .828 75. .079 10. .853 1. ,00 30. ,48

ATOM 2578 N ILE 2216 17, .885 74. .499 11. .510 1. .00 26, .76

ATOM 2579 CA ILE 2216 17. .747 73. .206 10. .892 1, .00 27. .79

ATOM 2580 CB ILE 2216 18. .734 73. .078 9. .715 1. .00 27. .12

ATOM 2581 CG2 ILE 2216 18. .621 71. .708 9. .083 1, ,00 28. .89

ATOM 2582 CGI ILE 2216 18, .418 74. .153 8. .671 1, ,00 27. .77

ATOM 2583 CDl ILE 2216 19. .258 74. .069 7. .413 1. ,00 28. .95

ATOM 2584 C ILE 2216 17. .940 72. .055 11. .853 1. .00 28, .07

ATOM 2585 O ILE 2216 19. .017 71. .907 12. .441 1. .00 29, .76

ATOM 2586 N MET 2217 16. .891 71. .241 12, .004 1. .00 25. .11

ATOM 2587 CA MET 2217 16. .931 70. .075 12. .885 1. ,00 25, .02

ATOM 2588 CB MET 2217 15. .785 70. .111 13. ,897 1, .00 25, .93

ATOM 2589 CG MET 2217 15. .711 71. .336 14. .777 1. .00 30. .67

ATOM 2590 SD MET 2217 14. .404 71. .152 16, .030 1, .00 37, .94

ATOM 2591 CE MET 2217 12. .915 71. .200 15. .008 1, .00 32. ,03

ATOM 2592 C MET 2217 16. .840 68. .748 12. .127 1, .00 23, .05

ATOM 2593 O MET 2217 15. .772 68. .382 11. .618 1. .00 23, ,87

ATOM 2594 N ASP 2218 17. .952 68. .027 12. .057 1, .00 19, .07

ATOM 2595 CA ASP 2218 17. ,967 66. .734 11. ,395 1, .00 17, .04

ATOM 2596 CB ASP 2218 19. .408 66, ,293 11. .096 1. .00 19, .60

ATOM 2597 CG ASP 2218 19. .938 66, ,862 9. .781 1, .00 26. .60

ATOM 2598 OD1 ASP 2218 19. .482 67. ,956 9. .391 1, .00 30. .39

ATOM 2599 OD2 ASP 2218 20. .818 66. ,232 9. .137 1, .00 29. ,07

ATOM 2600 C ASP 2218 17. .266 65, ,682 12. .266 1. ,00 15. .55

ATOM 2601 O ASP 2218 17. .126 65. ,829 13. .480 1, .00 9. .21

ATOM 2602 N SER 2219 16, .791 64. ,632 11. .614 1. ,00 18. .32

ATOM 2603 CA SER 2219 16. .131 63. ,533 12. .295 1. .00 19. .16

ATOM 2604 CB SER 2219 17. .168 62. .498 12. .722 1. .00 20. .74

ATOM 2605 OG SER 2219 16, .575 61, .532 13. .563 1. .00 29. .39

ATOM 2606 C SER 2219 15, .305 63, .939 13. .497 1. .00 17. .12

ATOM 2607 O SER 2219 15. .735 63, .836 14. .643 1, ,00 17. ,72

ATOM 2608 N VAL 2220 14, .103 64, ,400 13. .222 1, .00 17. .02

ATOM 2609 CA VAL 2220 13. .202 64, .799 14. .276 1, .00 18, .02

ATOM 2610 CB VAL 2220 12. .095 65, .705 13. .731 1, .00 19. .17

ATOM 2611 CGI VAL 2220 12. .692 66. .990 13. .189 1. .00 19. .80

ATOM 2612 CG2 VAL 2220 11. .328 64. ,961 12. .630 1. .00 22, .22

ATOM 2613 C VAL 2220 12, .550 63. .535 14. .814 1. .00 18. .57

ATOM 2614 O VAL 2220 12. .417 62. .532 14. .103 1. .00 18. .14

ATOM 2615 N VAL 2221 12. .132 63. ,593 16. .067 1. .00 18. .04

ATOM 2616 CA VAL 2221 11. .463 62. .469 16. .704 1, .00 18. .22

ATOM 2617 CB VAL 2221 12. ,460 61, .595 17. .490 1. ,00 19. .68

ATOM 2618 CGI VAL 2221 13. ,130 60. .596 16. .551 1. ,00 15. ,48 in r~- in -* ι ιn ιn co o CM CM d d d d d d CM dd CMCN d d d d d CM CM CM ooooooooooooooooooooo ooooooooooooooooooooo d d H d d d d d d r~ d ιncD

Hio oo r~- ooco r~- cocnco o oθ dCN d dCN cn cnr-- co∞ r~ cncy>cn cn cn o d cn ocn∞ o oooo c^ _{d d d} d d d d d _{CM CM CM CN CN CM CN CN} d d d d d d d d d d d CN CM d CN d d CN d CM CN d CN d CM d d d d d d d d d dd dd d d d d d r I d ι o ol n1 •t' cM lD

d d CN CN CN CN CN C CM r oo o oo o "tf - -*i' "tf 'tf "tf '^ ^ ιn ιn ιn ιn ιn cθ 'Λ D o

CM CN CM CM CM CM CM CM CM IN CN CN CN CN CN CN CN CM CM CM CM CN CM CM CM CM CM CM CM CN CM CM CN CM CN CM CN CN CM CN

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CN CN CN CM CN CM CM CN CM CM CM CM CN CM CN CM CN CM C^

CN CN CN CN CN CN CN CN CN CN CN CN CN CM CM CN CN CN CN CM CM CN CM CM CN CN CN CN CN CM CN CN CN CN CM CM CM CM CN CN CN C^

HaHaH Q _ Q_ Q_ Q_ Q_ Q_ O_ s a aaaaaaaaaatf tf tf xxxxzz zzzzzzaaaaaaaaaaaaaaaaaaaco tf tf tf a a a a ω ω ω w ω xi co co co co c c o co H H H ιH-a H H Ha Ha H co c c co co c c a x x x x x x x x x a a a x

> > > CXι a a a a a a tΛ C CO CO CO C tf tf tf tf tf tf tf tf tf tf tf tf tf O O tf tf tf tf tf tf tf tf EH EH EH EH EH H EH EH EH EH H EH EH EH EH EH EH EH EH

CM CM d CM d d CM CM rl N CJ Ω tf a CJ tf acj tf aoΩΩ tf tf tf aoΩΩ tf o ω txiN tf acjcj υ o o z o υ o υ o o z oυooozoooooυo υυoozυoo zooυozυozυυυυoooυoυozooooυoz c o CN Cθ 'tf in _ϊ r-- ∞ c o c o "tf in ιo r- ∞ cn o d CN Cθ "tf i co r^ ∞ cn o C r^ d C CM CM cN CM CM CM C C CM r r o o t^ o r r o o -^ ^ '^ 'tf ^ 'tf 'tf "tf '^ "tf in i in i in in Ln Ln in in cD i_^

CD CO ID CD <O CO CD CO CO CD CD CD CD CD ID CD CD I_> _⁾ CO CO CD CD CD CD VD CD IO CD CD CD CO IO CO CO <O CO CD O CO CO CO CO CM CM CM CM CM CM CM CM CM CM CM CM CN CN CM CN CM CM CM CM CM CM CM CM CM CM CM CN CN CN CM CM CM CM CM CM CM CM CM M

00 rH

2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

© EH EH EH EH H EH H EH EH H EH EH EH EH H H EH EH EH EH EH EH EH EH EH EH H EH EH EH EH EH EH EH EH H EH H EH EH EH EH EH EH EH H EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH tf tf tf tf tf tf tf tf tftftf tf tf tf tf tf tf tf tf tf tf tf tftftf tftf tf tf tf tf tf tf tf tf tftf tftf tf tf tftf tf tf tf tf tf tf tf tf tf tf

O

Tf « f^ <_ ∞ oo o r~ r- d r~ o m r~ ∞ ιn "tf f ∞ m r-- o t^ r- d c i cN O o O "tf co r~ a in d oo 'tf c_i o a o r- oo f o cN cri '}' 'i' 'tf CTl O ^' CN CO OO O CΩ -J'

Ti d ro cD oo d i' θ rθ d oo τ ιn ro co r-- oθ 'tf d ro o oo r~- cN r-- in o oo r~ 'tf o ro oo oo cn oo r-- cD in r~ cN 'i' co cM r~ ^^, ro ro in d O _> d oθ "tf _> co ro d o fN

O -P. ∞ m d θ ∞ ∞ σι o d o r~ O Φω ω t N m oo (η ω (O v o ιη ιn ^ w ι ^ o m ^ ω fn ω ιn ι N ιn α) n N n H ιn ∞ N "J ιn o (^ι co(!o o cs| H v ^

© d d CM OO d d d CM CM CM d CM d d d d d d d CM CN CO ^ in in in CM CM CM CM CM d d d CM d CM CM CM CM CM CM CM CM CM rO OO CM CO rO rO CM CM d d CM CM CN CM CM

CΛ

E? ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

CJ ft. d d d d d _<-t r-t _<-t τ-t r^ <-l r- r-i

_> d CN - d 'tf i coc ιo D CD 'r r^ r~ cτι σ^ σ^ d r~ r~ o ιn '^e M DcocD r_^ ooc o CD iθ ι^ cD in ^ ιn ro r^ d d d d d d d d d d C_M d d d d d d d d d d d d d CMCM CMd d d d d d d d d d d d d d d d d d d d dd d d d d d d d d d d d d

_> " θr^ o ιn∞∞ co r co oo oo oor~ ιn ^ 'tf oι ι^ c d ro _>cM 'tf oo dCD ^oo cM cocN in o ∞

"tf "tf CMcn r~- oo cM ro inco d co DcD co o ^ "tf ooin in cocn d r~- coo cncN d<o r~ cM r^ ro c 'tf r- in c^ r~ CD -~ co r~- d d tn "tf 'tf c r^ cn co o cn ιo cM r~ ∞ σι oo [^ r "tf c cM CN d θ 'tf cn ιo cN CN o ro o σι r^

CM ^ ^ C r 'tf co ι_ι - ι ιn co ι_ι r- co cn (^ r-- o o o cN d θ θ oo cM CM 'r ι ι cD cD iD CD VD r~- ∞

∞co oo oj oj m o ai ω ro oo co oo oo m oj oo co tJi wtn mw mΦCΛmσi mm mfli mffl m σi ffl m m co oo o ∞ cn c ∞c_M θ ->oo ro r _> r_^ r~ 'rιo -ro c d _> ιn ^ ro r~- _"tf CM co o oco "^ d cn 'tf cn cMCMcoo "tf cocD r~ ro cMc rθ'tf θo c ino r ιn o c^ "tf n(η ιoc oo Mθ θ c r^ r D Dι_n ∞

CN O ooo c docMcocno ocM i 'tf σi ooσ^ cN _'tf L cM ∞ CDoo ooco r^ ood cnoiΛ D D 'tf e in o DCM O CM in o σi c^

CM CM OCM θr0000000d CM "tf in00 'T m "tf 00 'tf 00 ιnιn ιnCDLn "tf C0CDr- CD ~ c0CDCDlO ~- CD 00C0 d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d

O O O O O d d d d d d d d CM CM CM C CM C CM C ro r r c^ r 'T 'tf 'r 'tf "tf «tf '~P 'r in i in in in D io _> D io io co D cD D o cD r^ . ro , .oo , ,oo , ,r -o, .co , .oo , .oo , .oo , ,oo , .o , ,ro , >oo , ,ro , ,oo , oo oo ro o oo oo oo oo ro oo oo oo oo ro ro oo oo oo oo ro oo o oo oo ro ro oo oo oo oo ro oo oo oo ro oo oo oo ro ro oo oo oo oo oo oo oo

CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CN CN CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CN CN CN CN ON CN CM CN CM CM CM CN CN CN CN CM CN CM CM CN CN CM CN CN CN CN CN CN CN CN CN CM CN CM CM CN CM CN CM CM CM C^

W W ⁽Q W W t. U ^[ιl W W Iιl W W ιl J ιi a j i a D D D D D D D D D g 22 Z Z Z 22 tf aapsaaaaosaaaaxx x x x Ha Ha ι- ι^ Ha ι-a H Ha tf ft tf tf tf tf tf ι-a Ha H ι-a Ha ,-a Ha ,-a H co co c c co o co co xxaosa πaxxxxxxx ^{" "}

O O O O O H M H M rl H M H > > > > > > > CJ CJ O CJ CJ CJ CJ CJ CJ tf tf tf tf tf tf tf tf

CM d d d CN d CM d CM d d CN CM tf acj tfmcjc Ω tfaoc tf ac Ωfaiw tfacjΩΩ tf a tf cQ c Ω Cxi Ω txi co a tf tf a υooocozoooooυozυυoυoozυυoooooozoυυozoozooυ O Z υυυυυυυυoυozoυozυυ

Oθ dd CCMM rrOθ T'tf iinn ccDD rr^~ oooo oco oo d CCMM rroθ "tf in co r~ cD cn o d CN C 'tf in cD r~ ∞ cΛ θ d C rθ 'tf in cD r~ oo cn o d cM rθ "tf in c^ oo o co co co co oo oo co tn i iji m m tJi tii in m tri oi o o o o o o o o o o d d d d d N N tsi N N t N N N N i to n in tn n n n n ^ cD VD CD io co co cD VD co co D VD io co i_i io o cD io cD r~ r-~ r~ r~ f-~ r~- r- r~ r~ r~ r^

CN CN CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CN CN CN CN CN CN CM CM CN CM CM CM CM CN CM CM CM CM CM C CM CN CM C^

00 rH se 2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo o EH EH EH EH EH H H H H H H H H H EH EH H EH EH EH H EH H EH EH EH H H H EH H EH H H EH EH H H EH H H EH EH H EH EH H EH EH EH EH EH EH EH EH EH EH H EH EH EH tf tf tf tf tftf tf tf tf tf tf tf tf tf tf tf tf tf tftf tftf tf tf tf tftf tf tf tf tftf tf tf tftf tf tf tf tf tf tf tf tftftftftf tftf tf tftf O

d CN "tf CO CCNM CCMM CCMM CCNM CCNM CCMM CCNM CCMN CN CN CM d d CN d CM CN ooooooooooooooooo ooooooooooooooooo r~ oo o D 'tf "tf o c -) D CD >_ι oo oo r~ σ^ ι ιn ιn ιn ro cN C CM d i -' in cD r~. oo oD in '~r ιn ^ ^ _ddddddddddddddddddddddddddddddddddddddddddddd ddddddddddddddd oo ιn o oo -t_f co in 't_f θ -> r-- ∞ c ro oo o Lθ 'tf in co θ ' d ∞ co co c -> cn r-~ αD c L^

CD CD "tf cn ιn r cn cD CD o oo ι σι cn Ln cD r _'^ r~ 'r t~- 'r oo cN c o D ro o cD cτι r~ oθ "tf C r o r~- «tf c^ o ro ι~ -~p r~ o ιn ιn oo oo oo ιn d oo oo cM cn co cn o d d ^ cM θo cn o r~- '^ o r-- cD ιn d CD oo ιn ^ o o oo r~ o oo r d CN C d θ d cN θ θ cn co oo r- -J r_^ r~ r-- _> -) ιn 'r 'r ro cN ro cN C CN CN CN θ θ c c c ∞ cn σ cn en cn cn σ cn <n co co co oo co co co ∞ oo oo co co co oo co co oo o3 θo oo cD θo oo oo r-- r~ r-- r^

^ Λ CD lD (B O H ιn ^ ι o ω w ^ ω ^ o » m lI! l H^ ^ σ^ ^ o ( ^ ιn ^ rt H Λ H ^ d d c^ ι ω m N Λ ιn w ^ oo m ^ ιi) N f ^ t^^ O (^l ι^γ) o ^ f c ιn "tf r^ t~ θ d cτι ιn ( d o ι^ ι^ cN CN CΛ c o cn ro cD r-. oo oo D r~- ι ιn 'tf f 'tf p- oo v^ o ιn '* ω ^ c O ^ n β ^ ι ι to o o o lnw ω H ιηω N OΛ o oo m a ^n f ^ ^ oo l ln ^ ^ m H ^■ιI H n o ιn ^ <o ι ol ^ H W (Xl n ^ cN θ c o c cn <- o o cn o OT ∞ oo -- ιo r-- r~ -> r~ ^to r~ _> -> "tf 'tf in o oo L^

co co oo cn cn cn cn cn σi crι cn o o o o o o o o d d d d d d d d d d rM CM CM CM CM CM CM θ ro oo oo oo oo oo oo oo oo oo o "tf «tf "tf 'r ^ ιn ιn ιn ιn ι^ o o r oo ro ro o ro ro oo oO 'T ^ 'tf 'r ^ 'tf 'tf 'tf ' ^ 'tf 'tf 'tf ' 'tf 'tf -tf 'tf "^

CM CM CM CN CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CN CM CM CM CM CM CN CM CM M CM CM CM C^ CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM a a fai fa] fa] ^χ] i-] fa] b] fa] z z z z z z z z cocococococococococoa a aa aosa ac-ii-s a a a

CM d d d CM CM d d CM d CM d d C d CM cj tf a CJ cj Ω tf a CJ Ω Ω tf a c Ω Ω a a ooozυυoooo tfacjo tf oΩfaiΩM CwMco tfa tf a J Ω Ω o z υ υ u o z o o z υ υ υ υ z υ z o o zooooυozυoυuυυυυoυozoυυoz u υ o υ υ υ o CN oo "tf in co r- cD cn o d c ro ^,^ in D r^ co c o d CN rO "tf in -> r~ c» cTi o d c^ "tf ^ 'f ^ -^p -tf "tf 'tf "tf in ιn ιn θ in ιn ιn ιn ιn tn co o o co _> ιo o -^ r~ t r~ r-- r-- r~ r- r~ r~ r-- - r-- r~ -- r-- r~ r [-- r-- r~. r_^ CN CN CN CM CN CN CN CN CM CN CN CM CN CN CN CM CN CN CN CN CM CM CN CN CN CN CM CM CN CN CN CN CN CN CN CN C^

00 rH

2222222222222222222222222222222222222222222222222222222222222 ooEHoHoEHoEHoHoHoEHoEHoEHoEHoHoEHo

© EH EHo EHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoHoEHoHoHoHoEHoEHoEHoEHoHoEHoHoEHoEHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEH tf tf tf tf tf tf tf tf tf tf tf tf tf tft_f tf tf tf tftf tf tftftf tf tftf tf tf tf tf tf tf tf tftf tf tftf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

O

PS

(N H o ι CO CM oo oo cD θ r^ cN _) o ro cn cn _) 'tf 'tf r"- r^ ∞ ιn ∞ oo o ιn o oθ d d ^ σ o ∞ co ro o ∞ ∞ cn o c cn oo cM d co o co o ro cM d θ cn ιn d cD CM CN co ι^ cD ^ CM Cτι cD oo d co r~ ιn d "tf in cM co cD oo co o cM "tf d o oo ιn r-- ^ cD o co ^ i c^- cN cn ro o 'r co 'tf in t^ 'r i co oo cn co oo 'tf - r^ d D in i c ro cn cD 'r in cD ^ CD o r in o ∞

"tf in "tf i cD ^r "tf r "tf 'tf in "tf "tf "tf in OO OO CM CN C CM d CO OO "t_f in r^ r~ r- CM CM d θ oo oo oo co r~. co co o o o o d σι oo oo oo cD ιn cD CD co r- r-- oo oo o cn cn dddddddddddddd d d d d d d d d d d cN in cN d oo co cn ro ro cn in "tf Co ro d cN d co r~ d cn cN d ro O ''r in co oO "tf ro r~- in c^ co en ro cn D ro ^,~p CM d 'tf D "tf r θ 'i" r~ c d r^ cN in ro D oo o oo o -tf θ oo cD ιo ∞ CN ∞ oo o cM in w cM CD o oo o3 CM r^ tri cD CD (^ o r-- - oo i "tf CM O in d oo <^ o o oo cN cn c c r~ cn co o cD o c^ 'r cD co r cn o oo io cD oo (^ d 'tf O ^ co ι^ r^ cD io ι cD VD ι 'tf 'tf ιn ro M CM d d cn cM c c oo r~ D r-- r-- ι_ι r-- co cD iθ ιn cD r~- ∞ iD iD co cD D D CD CD CD o io cD CD iD io iD cD D io io i n in in in in in i in in in i i in in in i in in i i in i i^ cn «t_f CM -' d "tf cn d cn _> 'tf 'j« o o ιo ιn cn cn oo r~ ιθ 'r cn cD r-- d d CM ro co θ d cM -> cn d d o^ cθ 'r ^ d o ro oo o oo cM cn cD (^ uo d <x> ιn o co ro oo ιn c^ θ "t_f CM CN CN oo r~ oo cn co d ro cM θ θ cN r~- r d oo θ d d θ θ CN r-- cD ∞ r-- CN r~ d "tf o c co cN θ o CM r~ d - CN ' o ∞ "tf co -^ co ιo r- .'r r cn cN in o vo ιo cN r - M

-t_f 'τ cM CM CM d 't_f tn ι cD t_^ oo oo ιn ^ ιn "t_f co cM CM in ιn ιn ιo ιo r~ r~ co oo ιn "tf Ln ιn ιn ιn ro cM C CM d i o ^

a -tf "tf

CN CN CM CN fc(-Λ (- (iιt- i- (iιj a aHi ahi ιjaj ajajdDDD DDDD D θt5U ut3 θt5C)ϋu c)<«ι;«ι;(( (<o OoOoOoOoOoOoOtcooncocococococo cgM ww co wco o tf tf tf tf tf tf tf tf tf tf tf tf tf tf iHH i- Hi i- i- iH H H H H H tf tf tf tf tf tf tf tf >>>>>>>>>>>>>> oooooootf tf tf tf tf tf tf tftftf tf tf tf tf tf tf aaaac-ιaaaa a a a a a d CM d CM d CM CM d d tf aoΩΩ tf acjcj tf a CJ CJ tf a cj Ω di ti tf acjΩ fai co aa tfa Ωtfacj tf o Gfa] z oo υ o o υ oz υυυυυ oz υ υ υ υ o o oυυυooυoz oo υυz ozzυoz υooozoυυoυozυυυozυ c r 'tf i co r- ra c o d C rO 'tf in D r~. co w o CM ro -~f in co r~- oo o o o o o o o θ d H d d d d d d d N NW N« ( ( NN "i^, "» ιn ιn ιn ιn ιn ιn iΛ in ιn ιn ιoιo - co co co oo ∞ oo oo oo oo oo oo oo oo oo oo oo oo oo oo oo oo oo co oo oo oo oo ∞ ∞ ∞ ∞ ∞ ∞ ∞ ∞ ∞ ∞ ∞ ∞ oo ∞ oo

CM CM CN CN CN CN CN CN CM CM CN CN CN CN CN CM CN CN CN CN CN CN CM CN CM CM CM so

2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo tf tf tf tf tf tf tf tf tf tf tftf tftf tf tf tf tf tftf tf tftf tftftftftf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tftf tf

O

'q^,ooo 'tf in '

ooo ooo θH m ^ω^Hiij^tηω ( ^_'j^oι »^d^^oιm(Nθ^^ (η^mo ino ^»(ϊ)HriθW(NθθNH( r-f^riN_"i'conιn<»ιn ι ol^omwMmlIι coιn^^oιηoιβHtηιDH ^o^(NO^ω^(ηN^tBNιnιnnocoNln(^ιιn omo N(lIιn(Nω roo^ ^D^l»

CD CN _CN d OO OO 't_f r-- l_) CN O O CM _CM _CO _CM CD CM _OD CD CM Cn θ O CM CO CM CO CM O _CO CM l^ ιn «t_f CM ^ CM CD ιn θ 'H n r- r_^ o r~ r- r~ co co r~ r~- r- oo cn co oo cn co r~ cn cn r~ o o d "tf in co ro -tf "tf ^' ^r cN CN CN CD CD r- oo n d d d d oo oo cn cn cn o d o o o o cn cn σι θ d d d d d d d d d d d d d d d d d d CN CN CM CM d d d d d CM CM CM CM CM CM d d d CM CN CN ιη (η α) φ ι w ιl ι ω w σι ιn m o ^ n lIO H ln ra ι ^ ω "^ o ιn ^ « ι σι ιn ιn w n m "J' H o o (I 0 (D ω(^ o o w ^n( d ιIι ω ω - ι ^ cn ro ro cN θ 'tf in o co cD θ d σι cN oo r~- CN Co cD ιn cD ro o co ro co ι~ cD o cD r-- σι cD oo 'tf in r~ θ d oo oo r~ ∞

_> oo d o ιn o cn cn ιn 'tf in ro ιn cn ro cn "tf θ 'H 'tf 'tf r cn _> oo o cn "tf rθ d co ro r^

00 CD r~ ι 'tf ro d d o σ> σ^ oo "tf 'tf "tf θθ 'r "tf "tf r cN c cN ro cM 'r ' 'tftf CCMM rroo dd oo σσ>> σσιι ccoo oo oo ccn oo oo oo oo oo ccMM θcn oo r~- oo cD CD CD CD in "tf ^r ro ιn ιn r- r-~ σι _>

'tf T ^^ ^ ^^ ^ 'j^ι ^r "tf r r cθ "tf 'tf "tf "tf "tf 'tf 'tf 'tf "tf "tf ' ^,~r "tf "tf ' "tftf ''tftf "'tftf ''tftf ''tftf rroo rroo rro "-tftf ''~rr ee ''rr ''tftf ''tftf '-^tf ''tftf '^^ oro ro oo oo oo oo oo ro ro oo oo oo ro ro ro oo ro oo

"tf <- r~- cN C Cθ '^ oo ιn cn d CD r~- d t '~r c 'tf C ιn σι r d o σ> ' ιn cM cn cM en cM d ro cn o c σi 'tf ro ^ D oo ^ co "tf r oo co co o ιn cN θ "tf "tf oθ "tf θ CN ∞ o r~ d io o d r~ CN CN d cn r~ cn c <o c in c^ co t^ oo ιn cN CN in o o c CM co ι d cM r~ "tf oo o d oo θ 'tf o iJ CD in oo ιn cn o cD d d oo cD 'tf "tf d oo "tf CM i σι cΛ r - ιn ∞ r- CO CM OO CM CM CM 'tf 'tf l' rO ^' d CM O O O d CM O O O O d d CM OO O d O CM C CO -tf CM CM ro CM O d CM O O O in r~ I I I I I I I I I I I I I I I I i i i i i 1 1 1

ro oo ro 'f ^,'r 'r "tf ^ " '>^, "tf 'tf 'tf ' in t LO L u in in co i^ o o io _> o c^ in in in in in in in in in in in in in in in in in in in in in in in in Ln in in in in in in in in in in in in in in in in in in i^

CN CM CM CM CM CM CM CM CM CM CM CM CM CM C CM CN CN CN CN CM CM CM CN CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM C CM CM CM CM C^

CO CO CO CJ CJ CJ CJ CJ CJ O CJ CJ CJ CJ O O O O O O O ω Cxi ω ω W W ω W D D D D D D D D Z Z Z Z Z Z Z Z Z tftftftfXXXXDDDODD ^μ H H cζ ⁽- i^j: i!u (i (- ι. (- ι, β; pt; tf (Sι- (-tf ι. ι. ad a a d ^ ^ ιi ωω [- H w ω ω ω d aa a a ιj a a a aa aπihiaaabi E-uu ω i] a a tf tf tf tf tf tf tf tf tf tf tf a a a a a a a M H M H H Hi Hi H Ha Ha Ha Ha Ha H c cj cj cj o j c c tf tf tf tf cjcj jc H n H Ha H H a d CN CN d d d CN d CM d CN z tf aoΩcxicoa a Ω tf a CJ tf a CJ cj Ω tf acjΩ Ω tf acj Ω fai fai tf a tf tf a CJ Ω Ω o o zυυυυz ozz υozoυυυυo z υ υ υ o o υ o z oυυυ υυo z uυυυozυozυυυo zυυo z υ υ υ υ υ

oo ∞ cxj oo cD OO cn cn cn cn cn cn CN CN CN CN CN CN CN

00 rH se 2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

© tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf t_f t_f t_f t_f t_ft_f t_f t_ft_f tft_f tft_ft_f tf t_f tf tft_f tf t_f t_f t_f tftftf tf tf tftft_f tf t_f t_f O

,^ i c c c m cN LO o cN O -> ^ r-- cN -> r^ r _m in co cM -O d O c o o o a in r r r^ ^~ o o cN crl o cM O o o co <^ r~ 'tf σ O 'tf ^ cN n o co c ιn oo ιn oo ^ ^■^ r r~ d CD d '^ co o cN d ιn ιn ιn ι cN ^^ ιn (B H ^ m o ω ^ vo^ ιn O "f fn ιn '» co σl 03 "^ ^ ιn ( o ^ ^ m ιn ol oo o o o ιn o ω ^fl o ^ ^ m N C ι (D o ιn H o ooι ιBO⁽ ^ι t^ l» ιB N r- co r— LO ~ r~ ιn oO OO O O CM O O O O O Cn CO O d CM d CM d CM CM CO 'r d θ r n 'l^, rθ «tf r '^ O O CM CM d CO CM rθ rθ ιn CM CM CM O O Cn θ ∞ d CM O O d d d d d d d CN CN CN CN CM CM CN d d CN CM CM CN CM CN CN CM CN CN CN CM CM CM CN CN CM CN CN CN CN CN CM CN CN CN CN CM CM CM <o oo <Λ iD CN rθ σ oo cM in cD CN d d ιn ι_) ^ "t_f 't_f 'r ro cN CN d CM θ θ c co cD CD i^ ι oo o r_^ r^ co o o o o D Ln ι "tf r r c i ιn 'r ι-θ D t^ cD ^ rO r OO n CO OO OO OO OO OO OO n OO OO CM CM CM CM CM CM CM CM CM CM CM CO CO CO CO CM CM CM CM CN CM CM CN CN CN CN CM CM CM CM C^

'r cN d "tf CN o cD 'tf in -> r~ d c r~ cn r^ cN CΛ ro oo ro cn 'tf "tf ∞ d oo r^ d r ro ro ∞ ro ιn d ιn cn cn o o r~ cM CM co ι D r~ D o ιn o OT oo ιn t^ d θ 'r t-~ [^ ιn ιn t^ ro cM CM θ oθ 'j" D ι r~ '^ "tf r^

O d r i c i r- cD 'tf o oo o cM i 'r r^ in in i in -tf o oo t^ cM r σi d in in d σi r o d CM C tη cD d CN r^ 'tf D in r_^ r_^ oo oo oo r_^ co oo oo r^ σi O o σi co r_^ t^ cD O O d C co o 'r ^ cD ro o ^ 'tf 'tf r in co cD r^ oo o ∞ "

I I I I I I I I I I I I I d I I I I I I d d d d d d d d d d d d d d d d d d d d d d d d CN CM CM CM CN CM CN CN CN CM CN CM CM CM CN CM

I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

d d CN CN CM C CN CN CM oo r o "tf τ 'tf "tf 'r "tf ' 'r ιn ι ιn ι ι-i ιn Ln ι^

CD _> _> _> IO IO CO - CO CD _⁾ CD _⁾ _> -> IO CD IO CO IO IO CO ID CO CD CO IO CO CO CO IO CO IO CO CO CO CO CO IO _^

CN CM CN CN CN CN CN CN CN CN CM CM CN CN CN CN CN CM CM CM CM CM CM CM CM CN CN CN CN CN CN CN CM CN CN C

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CN CM CM CM CM CM CN CN CM CM CM CN CM CM CN CN CN CM CM CM CM CM CM C^

D D O O O O O O O zzzz zzcococococococococoaaaao os |_HlHlHlμlHaHlH rt l*fξia; DDDDDDDDXXX ωωaaaaaaa HaHjHaπJcocococococococoxxxxxxxxxaaaaaaatf tf tf tf ^■tf -tf ^■tf -Ha - ,-a H_{H H} ι- b] fa] i i fa] [χi fa] fa] fa] ι- ,- ι-i π πi a aa a a a a tf t 33 zz f tf tf tf tf tf tf tf tf tf tf π μaH iHHiH HaH]HatH HEHEHEHEH-H>>>>>>>tf tf tf tf tf ι-iH H ι-iHaHaHaHacjoo d CM d CM d CM d CM

Ω tf a CJ tf a tf a cj Ω Ω tf a CJ Ω to co tf a o o tf a c tf a tf acjΩΩ tf oozυυυoυ z υ υ υ o z υ υ υ o z υ o υ υ υ υ υ z υozooooυo z o o o υ o o z υooozυυυoυυozυo

^■^ ιn _> r~ oo c o d CN o "tf inco r^ co cno dCNcθ '' in ->r-- cBc^yι o d CN m 'tf i^

CN CN CN CM CN CNoo ro ro oo o o coro r "tf " "tf -^ "tf "tf "tf '^ 'T "tf i Ln ιn L^ cncncncncncncn cncx*cncncy cncncncncncncncncnα^cncncncncncncncnc^ rH se 2222222222222222222222222222222222222222222222222222222222222 ooEHoHoEHoEHoEHo o EH EHoEHoHoEHoHoEHoEHoEHoEHoEHoHoEHoEHoEHoHoEHoEHoEHoHoHoEHoHoEHoEHoEHoEHoHoEHoEHoEHoHoHoEHoEHoEHoEHoHoEHoEHoEHoEHoHoHoHooEHoEHoHoEHoEHoHoEHoEHoEHoEH tf tftf tf tftf tftf tftftftftftftf tftftf tftftftf tftftftf tf tf tf tftf tf tftftf tf tftftf tftf tf tf tf O

H

O O d

"t_f i o r-- c^ c uO d ' io _^ ro r-- '^ r~ d oo io ^ i cD CN CO CD o r o r ' O d c _^ oo o oD co σi c r^ in o cD c oo cN o in i D d d r^ o cM cri ^ cM i σi i o oo r^ cD oo d r^ in D i d n d t-o oo oo ^ '^

H co (η o m [^ι Φ a o m (^) σ o ol lD ^o H lJ ιn o '_^f (η fl N "^ ^ ιn ^ n N' Λ o o3 H tDH O d ^o ^ ^ H cι oo o3 m ιD ^ ^o ω ^ Ol d o^ ^ ιo ^ d d tl (η m d O HOoo o d o tι oιo fl\ _ (Il (Il α) O l O O MO ffl 00303 ^ ^ ιo ^ ιo ^ ∞ ^ o)co o (^l N ^ ^ ιo ιc ^o ιn(nc■ ^• ιx) Ol Ol

CM _CM CM CM _CN CN CM CM CM CM rM CM CN CM CM d CN d d d d d CM d CM CM CM CM CM d CN d d d d d d d d d d d d d CN CM CM C d d d d d d d d d d d d d o ro ιn "tf r~ c ro r D cM 'r ιn co o co d o CD 'tf cn ιn co d i ιn d CD oo c 'tf co ι^ ι ∞ c "tf in "tf oo oo cM ro r^ r^ c^ o cn en o oo cn o cM "tf e ro cy> cN in oo cn ro D io in o cD cn co ~ o^ d in (^ CM c cM co cD d OO o r^ d r^ c^ ro d ro co r_^ CM cn in in σi r^ σi 'tf r^ eo cM ro o oO 'tf in o o cM -^ oo o oo d o in oo cM 'i' O d 'r oo o cM CD in cn co r^ in d r^ co r~ co r- cD σι oo o d CM CM d rθ d d CM CM d θ d rθ "tf "tf in cD CD oo r^ cn Ln "tf in ιn 'tf ro cN CM θ d θ co r-- ι_ι oo oo oo o^ CM CM CN CN CN CN CN ro oo oo oo ro oo oo ro oo oo ro oo ro ro oo oo ro ro co oo ro ro ro ro n ro oo oo

H ^ι ω ra ιn ω ^ o H n <ϊ ιn ι' ^ (^^ * ιn » ^ ιn o ^■^ •^ σl 00 co ^ H ^ N ^ ^ ^ tn 'ϊ ^ι ιo v ^•^ cι ^ ιc' O H ιn ω ω ^ ιη ^ ^η ω σι o N tJl O » -

't_f θ d cN i cN CD o cD θ c ιθ 'tf ^ cN "tf d r~ _ι^ d i o ^ t^ cM cn r^ d o r-- cτι ιn d CM d d io ^ o cn ιn 'tf σι ιn ιn θ "tf ^

'tf io ^ co co in d co d c o i-o o co cM C^ in r^ i 'tf i oo i n cN O 'tf CD O o co e in oo 'tf o r^ c d oo cn ^ o d in o cM ι_> «t_f ro cN CM ro oo oo ro ro ιn ιn co d d o σ^ oo cn r~ oo oo r^ r-- r~ oo cn cn cn ιn ιn ιn ro ro oo cM "tf ro -* oo o^

CN CM CM CM CN CM CM CN CM CM CM CN CM CM CM CM d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d l I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

O d d d d d d CN CM CM CN CN CM CM CN r0 00 l^ r00000 00 "tf 'tf 'tf 'ϊⁱ ^ "tf " 'r ^•,^qι ι-n) ι-nϊ ιUnJ m-) m-ϊ m_l muj muι m_) ι_nϊ ι^n cD CD co co cD cD cD CD r- r- r~ r~ r-- r- oo co oo co co r~ [~ r-- r*- l~ r- r- r- r-- r~ l~ r~ l_"» r- r~ r- r~ r-- r~ ~ r- r_"- r^ l~ l~ r~ r-- r"- r_^ '^,~ r-.

CM CM CM CM CM CM CM CN CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CN CM CN CM CN CM CM CN CM CM CN CN CM CN CM CM CN CM CN CM CN C CN CM CM CM CM CN CN CN CM CN CN CN CM CN CN CN CN CM CN CN CN CN C^ a a a a z z z z z zZHaH Ha H Hai-a H o DDDDDDD D fai ωi-i ωω ω ω ω c-iωωEHEHEH EH EHEH EH HCocococococ cocoωcoc Ha w ω ω ω ω ω coco w c co ococo tf tf tf tf tf tf tf H Ha Ha H Hi H H H H a a a a a a a ωfaiω ω ω ω c-iω x x xx xx x co co co co w co tf tf tf tf tf tf tf tf >> > > > > > cjcjcjc cjcjcjcjcja a a a a a a a aa a22222222 oooυo Ha Ha Ha Ha Ha d CM d CM d CM d CM tf a o tf a cj Ω Ω tf a cj cj tf a CJ Ω j ti tf m c fa xl t a CJ Ω fai tf a tf a CJ Ω z υ υ o o o zυυυozυozυυυυυ ozuooυoooo zooυυΩoΩυlot coOυ f oz oυυcoo o z o oυcoz υυυυ ιn cD r~ α3 crι θ d CN c 'tf i D r^ oo oo o d CN θ '^ ι cD r~ ∞ cyι θ d CM (^ "tf in cD t~ co cn o ( rθ 'tf in co r~ ∞ σ o d c^ cD oo oo oo oo cn cn cn cn cn cn σi cn cn cn oo o o o o o o o o d d d d d d d d d d CM CM CM CM CM CM CM CM CM CM ro ro ro c c ro co ro ro cO 'tf 'tf cn cn cn cn cn cn cn cn en cn cn cn cn cn cn o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o CM CM CM CN CM CM CM CN CM CM CM CN CN CM CM ro ro oo oo co M r ro oo i^ ro ro ro ro ro oo ro c co oo ro co m

00 se 22222222222222222222222222222222 222222222 2222222222222 2222222 oooooooooooooooooooooooooooooooo O O OO O OO O O O O O O OOO OO O O OO O O O O O o o

© tf tf tf tf tftf tf tftf tftftftf tftf tftf tftf tftf tf tf tf tf tf tf tf tftf tftf tf tftf tf tf tf tf tftf tftf tftf tf tf tftftf tf tftf tf tf tf tf tf tf tf tf O

Ό» r- . !. o o cθ d o d oo cN C ro oθ "tf θ 'tf θ θ d ιn ιn cD r~ 'r cn 'tf 'tf oo r~ r r-- co cD o r r-~ 'tf ^ oo o r-- cM < d r 'tf (^ o csi ιn co r^

Tt o r~ oo oo d "tf d 'r r~ oo oo c -tf oo ιn co oo oo r^ cD CN co d in c CN d c 'r ιn ∞ θ d ^ r^ o ιn ∞ ιn o w r^ "tf r cN d o^ J o IKH ιn » (^ι ^ N o ^ ra N o ιJl w o N Nf ^ d Λ H ιn o nι» H ι n t^ o Λ o o co n tD m^ ι w ^ <l' ^ co eo H ^ o tη m tΛ O O M O co o H ffl (^l

© OO rO CM CN CN CM d d d CM d d CM CM CM CN CM CM d CM CM CM CM d CM CM CM CM CM CM d CM CM d CM d d d d d d d d d d CM CM rO OO OO CM CM CM CM CM CM d CM

CΛ

E ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H? ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo υ a. ddddddddddddddd d d d d ro ro cn cM -o ro r 'tf σ r- ιo -i' θ d o co oθ d iD -> ιn cθ Ln oθ 'tf d cn _> ∞ d d "tf cn d CM Cθ d r^ ro in cn cM co in cM in o in d co d co o r cM co cΛ 'r in c o in o r d i O 'tf r o d cΛ r 'tf r^ cn r^ cD i r^ cM CM cn cD i^ ∞ ιn c cM d in ^ d c c ιo cM CM CM CM cn ιn cN θ o cM en co c σ^ o co cD CD r σ^ D d o r-~ r~ cn ιn θ 'tf N ∞ r^ o d co co m OO d CM "tf LO "tf "tf m T in m -r ro -r oo c CN CN O O oo o oocn cncn cn co oo oo r^ r~ cD Ln ιnιo r^ vD co ιnvD t~ oo r~ co ιn r-- oo r~ oocn cD cD ιn

CM CM d d d d d d d d d d d d cD cn d oo d o ro r^ ro θ 'tf d io ro ιn cM cn cn cD cn r-- ιn ιn cD CN r^ co r--- r^ cM Cθ CD o o oo d r~ CN CM oo cD CM ro cN ro o v^

(n ^ ^ tn H N ω σι O (D ω H o ιfl <J ιησ^ ^ ω ι oD ^ o ω ^ ιn ω o n „ w ^^ H H lO Λ « ^ ιη ^fl o o^ ^^ "t "l^, (I) 0 ^|- o o ιn o^ ^ ^ toω cN co cn cN θ "tf "tf i^ o ∞ _> cn cM oθ ιr> co cn ιn r~ cn θ "tf in ιo co o cN oo cn cn ro co cN t^ ιo ιn t N « « ^ « n ln ^B ιn ^ ^ co t ι o to σι o (^ι w α! _ o3 ω o o O N c^ι ^ Hf ^ ι n H d ^l O d O d H n M r H m (Jι m o ^ ^D ^ ιo ^ "tf 'tf 'tf "tf 'tf "tf ^r ^ 'r ''r 'tf -^ ^ "tf "tf _'tf Ln 'r 'tf Ln L 'tf 'tf ^,tf "tf '3 "tf in ιn ι ι ιn Ln ιn ιn ιn ι ι ι ιn ιn ιn ιn ιn ι^

<o cN r~ co ιn oo rθ 'r oo θ θθ L σ^ "tf cn ιo σi d r "tf C^ o ιθ "tf d o c© o ιn d σ o σ oo o cn o o ιθ "tf 'tf CN co ιo ιn ι^ o ^

CD O d r 'T OO O <M r~ r~ CM CO ιn ^ d "tf O CM O CD CM CM CO CO CO r-- d O CD 'tf d CN O d «tf "tf r^ O Cn oθ CM CO CD C Cn CD Cn r^ co ιn "tf -'r -' r~ co r~ cN d co cn cN θ cN in d ∞ Lθ d co r-- o cn ' ro o ιn ιn ro oo d cN oo d CN CN m m m 'tf m 'r m 'tf D 'tf ^' CM CM d o o o o d d d d CM CM d CM O O d d CM θ θ d d o ro r "tf in cD r- r- r- co m m m cD m m co r~ co

I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

(D co to aj ^ m m cri m m oi o o o o o o o o o o o o d H d d N N CN' N N N N N to fl M M t M n ^ ^ ^ Hf ^ 'i' ^ ^ ^ in i in in i in in - t^ r~ r^ r-- r^ r-- r-~ r^ r-- r-- r~ CD θo oo ∞ oo ∞ ∞ oo oo oo oD ∞ ∞ oo oo ∞ ∞

CM CM CM CM CM CN CM CM CN CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CN CM CM CM CM CM CM CM CM CM CM CM C^ CM CM CN CN CN CM CM CN CN CM CM CN CM CN CN CN CN CN CN CN CM CN CN CM CN CM CN CM CM CM CN CM CN CM CN CN CN CN CM CN C^ co co co co i-a ι-a iiiHiπi^HaaaaosaaaaaaaactaaaaacMaaac ac OOoo O O O Z Z Z Z Z Z Z Z Z O O O O O O O co

X X X X tf tf tf ttf a a o H Ha h Ha Ha Hi Ha H H p os a a a a a M πa πa μ] i-a > > >f> >tf>tf>xEHxEHxEHxEHxEHxEHxEπxEHxEHxEHxEHxEHcCχO]cCOχifaCO]Cfa]Cfa]CωOctfoctfoctfoctfoctfoctfoctfoctfoaaaaaaaa a a a o o cj cj cj cj o o o a a a a a a a a d CM d d CM CM d CM d co tf a o tf a c Ω fai Ω fai co a tf a c tf a c Ω Ω Ω tf a CJ υzoozoooυυoz υυoυυooυoυozυoooozυυoo ozofυaυcυυ tf oΩω CωM oυ Ωt ozυυυυozυoz υ υ υ o υ o D r- oo oo o cM rθ "tf in co r^ cD θn o d C θ 'tf in cD r^ co cn o cM rθ 'tf i D r-- co cn o d C cθ 'tf i cD r^ oo oo θ d CM rθ '^ ι^ ^•^ "tf 'tf 'tf in ιn ιn ιn ιn ιn ιn ι ιn ιn cD CD o o D CD cD o D co r-- r-- r^ r-- r^ ι^ r--- r~ r~ r^

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O d d d d d d d oo oo oo oo oo ro ro ro oo oo ro oo ro oo oo ro co i^ cη ro ro oo oo oo oo ro oo oo oo ro o^

00 rH se 2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H ^ t. tH H Eπ H E< ^ H H h ^ ^ H tH H tH H tH h h tH H EH H ^ EH H H tH H ^ E→ h h ^ EH H ^ h EH tH ri fH tH H tH lH tf tf tf tf tf tf tf tf tf tftf tf tf tf tftf tf tf tf tf tf tf tftftftf tf tf tf tf tftf tf tf tftf tf tftf tf tftf tf tf tf tf tftf tf tftf tf tf tf tf

O

Tf f- •a CM cn d LO ^ -i ro d io -w ∞ oo d r-^ o r 'tf O c o in co oo c O 'tf CN ∞ a in c io cn i^ cx)

Ti 00 "tf 00 iD c r^ CN ro ∞ C oo co cn oo cM Ln ^ cN 'tf r cD oo in d O in cη r D in oo o ∞ r^ cM ∞ cM ^ in r^ r^ oo i 'tf CN r^ cM CΛ d r^ fM r~ cM in o 'tf in d o yι d cn o o ιn rθ "tf "tf r^ ∞ θ f r~ 'tf r~ rø D oo ιn t~ r- D ^ r^ ι ιn r ιn o o ∞ o σ^ σ^ co c cM incM r^

© CM CM M rO rO rO rO CM CM d CM d CM CM CM CM CM CM CM CM rO rO OO C^ CN CM CM CM CM CM CM CM CM CM CM CM CM CM M CΛ ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo υ d d d d d d d d d d d d d d d d d d d d d d d d d d

"J n _'ϊ ^ ^ σι ^ ^ d M ^ H co ^ ω ^ H o^ v ιn ^ _ ^ t^ H l H ιn ιc n ^ ω ro l v ω Hf ι o Ol ω 'lI o lo ffι ιn coω tocooo ι£ι ^ - N' o o m ∞ ι i ∞ ∞ _ι^ r~ o r_^ cM ∞ cft eN cn c "tf C i σ! d n d c -> cN c 'tf d .^ L^

"tf c c o o cD iθ d c σι ι~ cM θ ^ ιo cN CΛ cN r^ o cN CΛ <» c r~ c c ι^ r--- c cn iD θ CN CN ∞ c^ ιn o ro cM CM CD in co r~ σ o cn cΛ r~ o r^ ιo ι ^ cM d CN ι~ cn r^ oo ^ o cM CM CM d CM 'tf θ '^ r-- CD ι-n. wo30w d, , ω N H to N M N Ci ιn (n ιo n σι . ccθθ ''tftf θθ ''tftf d cθ 'tf ro o o cn cn ιn ιn o d cN cc ''tftf oooo ιιnn cM r-- "tf d r-- "tf θ oo 'tf CD "tf "3' oo oo ιn ιn 'τ ιn oo cN 'j' ro ro ro cM CM d c "tf CM θ cn co cn cn cn r^ co ι^ r-- cD D r^ co r^ ιn cD co t-~ ιn D ιn ι co cM C r oθ 'tf o σ^ cn r- r-- iD ^

^^ ^J^ ^^ ^ ^ ^3* ^* ^3* ^3 ^ϊ* ^3^ * ^3* ^ * ^3^ *!' 'tf 'tf co oo oo oo co ro co t^ oo oo oo ro ro ro oo oo n ro ro oo ro oo oo oo oo ro oo oo ro ro oo e^ co d θ 'τ cD C θ d CD d CN C r~ cn ιn σι ro o -^ 'r ro cD CN CD r-- o ι 'tf θ cn 'r cD r-- ιo σι ^ r cN o r-- Ln c o cN o c c^ r oo ιn cM in c^ o CD CM C ιθ "tf "tf i o ιn ι^ oo r-- '^ ιn "tf θ θ cn ιη cM ro ι θ '^ CM r ιn oo cM -^ 'tf '^ C r cD θ d ∞ r-- c^ ιn "f r- m m H oaιo ωιB _ ω o^ ^ ol o ω ln tN ιn r^ "t^ι "f 'r wω ^ <τ ^ ιcN Φ O to ι ra Φ H N O (^ι m o ιn ra '» ^ N ιn H ^ o m [B ^ ^ ln <f oo oo cn o en d d co r- cn cn o o co oo o cN O d d d d d d d o cN CM ro ro cN CM CM ro ro cN d d C ro cM CM d o oo d CM d ro ro in LO in in in cM CM CM d o cn

I I I d l dd l I I I dd l I dddddd ddddddddddddddddddddddd I ddddddddddddddd I

I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

_> _5 co co

CN CN CM CM co cocococococococowcxiω ω ω ω ω fai zzz zz z z z z a a a a a aa a a a aaa a DDDDD DDDco cocococococo cococo cococo H H HM H H πa i-a iH H H i-i H H H iH H H iH Ha Haa a a a HxSa a a osa c-i a ω xi ifaifai ω ωfai x xxx x x x x H HH xs a sϊa ϊϊSHHHHHHHHt5out. uαui3i5EHH tHEHHH[ιtHfHhBHhddιiaaddaj-dadaaaaaϊiικ tf a o υuo tf oΩbiN tf ao υ zυoυoozυozυυυ r~ co c o d CM rθ 'tf in D r-~ co cn o CM rθ "tf in iD r-- cD σ^ o d cN r "tf in o r~ oo cn o d CM rθ '^ ιn cD r~ ∞ σ^ θ CM rθ "tf

O O O d d d d d d d d d d CN CM CN CN CN CM CM CN CM CN rθ rθ Oθ r O O O OO CO O -^ '* "tf "tf "tf "tf 'r '^ ' '^ ιn ιn ι^ d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d ro ro oo n oo oo oo oo oo oo ro ro m oo n oo oo ro oo n ro M oo oo oo oo oo ro ro ro oo oo oo oo ro oo oo ro ro n se 2 2 2 2 222222222222222222222222 22 2222222222222222222222222222222 o HoHoeHoEHooHoHoEHoEHoHoBoHoHoHoHoHoEHoHoEHoEHoEHoHoEHoEHoEHoEHoEHoHoHoHoHoHoHoEHoEHotHoHoHoHoHoHoHoHoEHoEHoHoEHoHoEHoHoEH EoHoEHoHoEHoEHoEHoEHoEHoEHoEH tf tf tf tf tf tftf tf tf tf tf tf tftf tf tf tf tf tf tftf tf tf tf tf tftf tf tf tf tf tftf tftf tf tftf tf tf tf tf tf tf tf tf tf tftf tf tf tf tf o

r-

Ti lηιηmoto ^ιnocoHO ιn(NιηdlONO(N(^ιw^9ιn r_"»^lN(ηMΦHω^lJcocot H ι^dHlcωι (^ιoo^m^^n Λ^c^ι <I_'07 o ωo^ommιη(ηot^( Φtηιn ιιn^o^HfmoO"l_'OO^mooιnoω<»olO(nσιd ι (J^ι^!Hιnoc-d(Jl(rιlB(JιΛl»^ιo

CJ

© CM -l" CM CD β ( Ho^ι„m(J\HH*Ht σιm^ι«^ONH'f"Jιn( NNHC HNoσι^mowmι nωNι ιonln^^mffιι (^,lr^^OH(^lH

^■ "tf ^ ' M r rθ 'r 'r 'tf '^ ^ O _> CO r^ r-- r--. lo lβ ⁽O O lO O *O O O CO O ι^ -ji in i

CΛ

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O

H O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O υ o- r-- " ro ιn _>o ιn σι ιn σ> σicM d cn 'tf ro cN CD Co cMCN dcM cno c oo dro r- ιnn Hr >_ιcDCD oo cM ι o "τn dOOl ιn(^ιωoc^l r• oι»l H Mm ιn H O r~ r-- oo cor- '3i i. r ro ro c c rM CN OOOOOOOOO d O O O d CM CM rO rO d d d O o o o o H N H N N iη rH w n^,ι n N rg H ^[η N (^,n "» l I I I I I I I I I I I I cN ∞ "t_f ∞ ^ co o o ^ cn cN in o -> r d θ d d CN σϊ C CN θ _'rjι r cM r_^ "t_f ro d c ^ σϊ oo cn ω

O "tf d o i_> in oM in o cn in o oo c c o cM U3 o o r^ i in oo d 'tf 'r i cN d o c cn d CN CD in r^ o^ i io OT d tn oo cN i^ oo oo i r co en cn ' 'r r^ ^ r- ∞ cn r rM 'tf CN CTi M C co r^ d co d cM CM i D 'tf d o o cM r o o σ^ r^ cD cn σ^ r^ r^ co r^ ∞ ι .tf 'tf c ^ ro ιn _> CN CN ro r ro c CN ^ 'tf -^ ι r~ r^ c co ιn «tf i^

CM CM CM CM CM CN CM CN CN CN CM CM CM CM CM CM CN CN CM CM CM CN CM CM CM CM CM CM CN CN CM CM CM CM CM CN CM CN CM CM CM CM N

CM i^ o co cN CN d cτ cN r~ c cn o d <n r~ ιn o σt d 'tf c r~ 'tf oo α i r ιn cθ ' io ^ co ιn co cD r-~ r^ o r^ ^r θ cn o ι o ^ σ^ oo oo cn cn 'r cn d in r^ co co co oo D oo θ cN r^ "tf i^ d o D r-- '^ σ^ o ∞ e CD d θ ιn d i^

^ N in N io m iD in ^ ino flO Mii o iD ai N oo o N r- o o H m ci o ^ o o v ^ eo ι ι'l β oo 9ι ^ (Λ ιn ^ Φ ιn o ln ιo o ι* ^ Hf ^^ι tJ^ cι ^- o ^l l ιn

Ol t ^ roN ⁽^CH tn HI ιn ιn ιn^ d d OO d o l d o ι ι^rl n d l d ll' ιn ιn 'l' ^o ^D ιn ^ ^ α) ⁽Jl o o olOl O(Λ mol o o d d o<Iι o^ι r^( ιn ιB ^ _ i

I I I \ rH rH rH rH rH <-H rH rH rH rH \ I I I I I I I I I I I I I I I I I I I I d d l I d l I I rH rH rH rH rH l rH rH rH r rH rH rH rH C

I I I I I I I I I I I I I I I I I I I I I I I I I I

cN CN CM CN CN CN oo ro ro o o o o ' "tf "tf ''r -^ "tf 'tf ^ ιn ι -o ιn ι ιn Lθ i^ cn cn cn cn cn cn cn cn cn cn cn cn cn cn o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o cN CN CN CN CN CN CN CM CM CN CN CM CN CN ro oo ro oo oo ro ro ro ro ro oo oo oo oo oo oo ro oo oo oo oo ro r^

CN CN CN CM CM CN CN CM CN CN CN CN CN CN CN CM CM CN CN CN CN CN CN CM CN CN CM CN CN CN CN CN CN CM CN CM CN CN CN CN CN co w co c co co fai i ω ω fai fai bi ci z z z z z z z z D D D D D D D O o o o o o o a a a a a a a a a a H Ha i- H i-a H Ha z z z z z H H M M H H Ha Ha iH Ha H iH Ha co c co o co c co c bi ω fai ω fai i-α M fai a a a o a a x x x x x x x x x x tf tf tf tf tf tf tf i- i- Ha H Ha a M H M M H M M tf tf tf tf tf tf tf tf Ha Ha H H Ha H ι-a HP a a a a a a a H EH EH EH H EH EH EH EH H H H > > > > > > > j cj cj j j

CM d d CM CM d d d CM d CM o d d CM CN d CM

Ω Ω a ed tf a o Ω tf a cj Ω Ω tf a cj Ω Ω Ω tf a cj tf a j fai Ω bi c a υ z o z υ o z tfaocj tf aoΩ υ υ υ υ υ υ ozυυυozoo υ υ υ o υ o o z υ υ o o o ozooυυυυυυoυo υoooυozυυυυ ^ o5 σι o ι m H^ ιn Φ ^ ι_ ⁽Λ O d N n ^ ιn - ^ (D σ⁾ O H N t^ ^ ιn Φ _ tIl ⁽Λ ⁽J^ o o o o o o o o o o d d d d d d d d d ^ι c (ι^ι cN M ^t CN^" d d d OvJ CM CM CN CN CM CN CM CM CN CN CM CN CM CN CM CM CN CN CN CN CN C CM CN CN CM CN CM oo po ro n ro ro n ro ro m

222222222 2 22222 2222 22 222 22 2 22 222 O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O tf tf tf tf t_f tf tf tftf E tfHtfEHtfEH EtfHtfH EtfH EtfH EtfH Etf^HtfEH EtfHtf-H EtfH EtfH EtfH EtfHtfH EtfH EtfH EtfH Et_fH EtfHtfH

I r ιn ro c r~ oo d oo o o oo -tf r- co r r~ r^ r cD _'^ ιn d oo cn r~ σι «tf C iπ _"tf CD θ 'J^ι ooιncx5 ^

Ti o τι ^ cN d o ocM oor~ oo cD oo 'tf c~ d cn 'tf o a cM in (Ticnooo D din ^ ro ιnr~ (^r r~ m r~ cn D c»

CJ o r^ co cNcoo c^cΛ in σ^cn d 'tf d d CMCM cn cMc 'tf or~ o ιn cτ c «tf in o o r-~ ι cMCM i^ oo cD in d coo ^ oιn oco c^ © ιn ιn -w -^ -^ror ro o "tf "tf 'tf "tf -^ 'r ''r 'tf "tf ^rθ "tf "tf 'tf 'tf in r cocNCNCM N CNCM C CMc^

CΛ ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo υ ftπ

r^ ιn cN cn o d CN io ιθ "tf r^ c cn ιn cN ^ ∞ ∞ "tf ι^ cn 'r o _> " d oo cn ro ιn d CN θ c^

'tf θ cn co ιn σ^ co ^ o ι^ cM d co ιn 'tf CM o o cM CM CD co d ιn d CM θ CM r-- ro co cD θ co ιn r~ oo o r~ -' oo oo r d co ιn

( c ∞ c cn cN c r^ d θ 'tf θ <-o d i o ι 'tf CD θ 'tf r-- - σ^ r~ d σ^ 'r ιn cN crι d in o c a c d c cθ "tf CD i c r^ cM ^ co oo d N ^ ιn Φ ιn ιn '^' V Hr l ' (^ l N Φ ^ (0 ( ι n "r ι ιn Φ H O ri o^ o o σι tJι ^ ^ ιn "l^, ιn tn Φ ι - Φ ^ ^ ιn oo ^ - ιn ιn tO N H H O M

CM ro ro ro oo oo ro oo oo oo oo oo oo oo oo ro ro ro ro r 'tf '^ ^,tf 'tf "tf ^ "tf 'tf "tf -tf i^ -^ "tf "tf t^ ro oo ro ro n oo o^

Φ ri ιn θl d in d m ιn θ (O θ n (\| tD Φ d Cn Φ Φ O "f d ^ W N O ( d tD O V N H 9 0 >I H (\| . (I! ^ C' O OO O H ^ ιn θ 01 C O N 'Φ - H o ol H d N rl| d H N Λ tn o « m ιn ι Φ Oι (η d H oo o3 ^ ^ ^ M co ιn - ω m ^ o ^ o w _ t^ ιn Φ o ^ι ιn Φ N ⁽Jι <Ji H ιn Φ O "» >- ιn o ιn -> " θ cn o o o c co ιn co ro c ^ cn r~ cN r~ ∞ oo «tf 'tf C in cD c cM CN Co r^ r d _> ^ r oo cn m ι^ι m m m "tf θ CN CD r- iD r~ - co iD oo r- oo oo cM CM d d o cM CM ^ 'tf i in i^ in cώ in D in -i r^ in i^ r- oo c o d d CN CM CM O d O d o cn oo cn cM dddddddddddddddddddddddd d d d d d d d d d d d d d d d d d d d d d d CN CN Ovl CN CN CN CN CN CM CN CM d d d OM C I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

⁽Λ Ol Ol Ol o o o o o o o o d d d d d d d Hf fl ^ l» <t ^ « * ^f ιn ιn ιn ιn ιn ιn ιtl Φ ^D tIι ι(⁾ Φ ιo ^5 ^o ^ ^ t" ^ ^ ^- ^ ^ (- lIJ (I) oo t)3 oo _

O O O O d d d d d d d d d d d d d d d d CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CN CM CM CN CM CM CM CM CM CM CM CM CM CN CN CM CM CN CM CN CM ro ro ro M oo oo ro oo oo oo oo ro ro oo ro ro ro oo co oo oo ro ro ro ro ro oo oo oo ro oo oo oo ro ro ro ro oo oo oo oo

CM CN CN CN CN CN CN CM CM CN CM CM CM CM CN CN CN CN CN CM CM eN CN CN CN CM CN CN CN CN CM CN CN CN CM CN CN CN C^

22Z ZIdIJUωiιl[ιlW[JDD3DDD D DDDDDDDPaadaadaDDD DD D3 DtOtOtOBtn B)t⁽l (βBltODDDDDD-

H H H Hi H H H H HaH HaHaw w xiωωwω H H Ha H H Ha HaH tf tf tf tf tf tf tf MMtxiwωaωM M HMM MHi ωω xiwωww i5UϋU HH H HH H HHaa aaHiaa C5ut5t- iDt5θ ! > > > >> Jd fH aa aaaa a a E aa Baaιι:aj aιia ιi d

CM CN d d CM CM CM CM d d CM M w l tf a cj cj Ω tf a CJ Ω Ω tf a CJ Ω w fai tf a cj o tf a CJ Ω Ω tf CJ Ω Ω fa] fa] tf a J Ω Ω o zυo z υoυυoυoz o o υ o υ o z υo o υ o o υ o z u υ o υ υ o z u υ o υ υ o o z υ o υ o z o z υ oz υ u υυ υ υ cnoH ro(Il OH ιI)01 cN r

CN CN CN eo oo ro r o r o o o co o o

00

2222222222222222222222222222222222222222222222222222222222222 rH oooo o oooooooooooooooooo ooo o o oooooooooooooooooooooooo oooooooo o © EH EH H H H EH H H H H H H H H H EH H EH H H EH H H EH EH &H H EH EH EH EH EH EH EH EH EH H EH EH EH H EH EH EH H H EH EH H H EH H EH EH EH H EH EH EH EH EH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

OOOOOOOOOO OOOOOOOOOO r~ ιo o _> _> d

(nooNOJ d "f ιn _> ' ' dco r~ ιn D in r_^ r~ dddddd _ ιn n r~ ιn CO CM CO Cn "tf «' r-- rM d 'tf "tf Cn in θ CD in "tf in CD CM d VD CO ιn CΛ (η r~ O ιn θO CM θ rθ O [-- (^ d lO CO O OO OO CO d CO ra

'r eN co co oo o -^ co o o cM in cn ro d cn in _> r^ ' _> cn co io tn -> co ^ ro io cM in Ln 'tf r^ σ d d ^ ^o co d cD ιn o oo 'tf CD ^o o^ 'tf 5 d co >_⁾ 0^ σ ro cD ιn r^ ι oo d o^ d co 'tf lD oo cD CD d cN [^ o oo d cN ro ιn o^ ιn

CN CO 'tf -' in 'tf CD CD OO OO OO OO in CD 'tf lO CN d d 'tf 'tf CO OO -tf 'tf CM d CM d d CM rO d OO d CM O Cn d d CM d CM CO CM O Cn O Cn O d d CM CO CM CM CM CM CN CN CN CN CM CN OM CM CN CN CN CN CN CM CN CN CM CM CN CN CN CN CN CN CM CM eN CN CN CM CM CM CN d CM CN CN CN CN I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

^{D ⁽Λ m m m ⁽Λ o o o o o o o o H d H d H H N ( l M ι l N t (n ιη π (η ^ t m o t^ ιη '* "l' '» 'l' v ^ "l' fl f ιn ιn ι^ ιn ιn ι ιn ι Φ - - Φ lD ^ cN CM CM CM CM CM ro oo oo ro ro oo oo ro oo oo oo ro ro oo oo ro co co co c ro oo oo oo oo ro n ro oo oo oo oo oo n oo oo oo o^ ro ro ro ro oo oo oo oo oo oo oo oo oo oo oo ro oo oo ro oo ro ro ro co co c co n n ro co ro oo oo oo ro oo ro ro oo oo ro oo M

CN CN CN CM CN CM CN CM CN CM CN CN CN CN CN CM CN CN CN CN CN CN CM CN CN CN CN CM CN CN CN CN CN CN CM CN C^

D CJ CJ CJ O CJ Z Z Z Z Z Z Z Z Hai-iHiH H HaH aciSaaaawωww ifaiwωwwωDDDDDDDDDaaaaac a a tf tf tf tf tf x cxiaaat-sacocococococococotf tf tf tf tf rtKwwwwwwaaaaaasaaa aHiaaHiaaaHirat noitnωω ω πi πi HI a HI HI πa tf tf tf tf tf tf tf tf tf tf tf tf tf >> >> > ^" >cocococococoaaaaaaaaaaacjoc oocjcjcjcjtf tf tf tf tf tf tf tf tf tf tf tf tf d CM d CM d CM d CM d CM d CM tf a tf a CJ Ω Ω tf a cjcj tf a cj tf ac Ω Ω Cxiw co tf aoΩfaici tf acjΩΩ tf a zooυozυoooz υozυoooυozoυooozooooυoooυ o z υυooooυozυoooooozooυ o z

00 rH

2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

r~ rθ "tf d r o d O r- Cn CD CM O

OOOOOOO OOOOOOO cn cn o co ιn -^ cn o ro c~ ιn cn cn _> r^ ^ _Lθ ro co r-- co _> ιn cM _Lθ cn cn o cN co cM cn r~ ι^ cn d d _> -^ "tf co D CN θ oo _> crι cn o d cn cN in r~ co cn "tf d co o r~ ^ co o - co r--- c ro c^

^ o o o d ιn "^ Λ O ι "^ (η H Φ ιn l H d - tn N - ^ ^ ιn N ιn co "» ^ O Λ O "^ r^ ^^ m o - Φ ι o oo 1 r- o r- ^- co (Il ι ι H o f ^ ^f

(M o "tf CN CN o o d d o cM d cM CM r d d CM CM d CM θ o en c cD θ cn d θ θ θ CM CM co ∞ cD in «tf L r~ r~ r~ r~ cn cD co ιn ^ 'tf dddddddddddddddddddddddddd d dddddd l (^ι ιη o ^ ^ o o o ^ σι N O m "_f ι co ^ l ΦN n o ^,ϊ ι H CD ^ H O <* J ι o - 'ι^, co H (Il (!l σl r- ι D ι ^ - oι o ^ ^ oo (^,^ ^ 'ϊ (^l 'τ

"tf d o d t~ oo 'r cD "tf CM co o cn c co r- "tf < i d o oo oo in in co iD oo r-- co c in i cM "tf "tf ro co co cM co "tf d OT M co ∞ ιn o o ιn _5 o cN "tf θ "tf 'r ∞ ιn co cD θ "tf r~ co o _> 'tf _> Lθ d θθ cN θ ro co cN t~ ι^ cO "tf in in cD in cD i_> in cD r^ r^ oo oo o oo oo oo o c a> oo o o d CM eM O M 'r "tf ^ co o cD o oo r~ r^ r-- r^

CN CN CM CM CM CM CN CN CN CM CM CM CM CM rO CM CM CM rO CM CM CM CO OO OO rO rO rO OO OO OO OO rO M OO OO rO OO OO OO OO OO OO OO O^ σι ra Φ d o ^ ol ^n o H O d O d m _> r- co co co _"> "tf O

00 CM CM d O cn 00 r- d d d d d 1 1 1 1 1 1

∞ co ∞ co oo oo oo oo oo cn cn cn cn cn c^ ^ σ^ cn cn cn cn o o o o o o o d d d d d d CM CN CM CM CM CM CM CM Co co oo oo oo o oo oo oooo ro rroo cc r cc oooo oooo oo oooo oo oo oo rr rcoo oo oo oooo oo oo ''tftf ''tftf ''tftf ""tftf ''tftf ''tftf ""tftf ''tftf ''tftf ''tftf «"tftf ^^ ^^ ^^ ^^ ''tftf ""tftf ^^ ""tftf ""tftf ""tftf ''r^ 'tf 'tf 'r 'j" oo oo oo oo oo oo oo c^ co co ro ro ro ro oo oo m oo oo oo oo oo oo oo oo ro ro oo oo ro ro ro ro oo oo ro oo oo oo oo oo oo oo n xxxDDDDDDDDDaaaaaaaaaaaaaaaaaaac w cococoDDDDDDDDtf tf tf tf tf xxxxzzzzzzz jaajιiJJιiιiajJ ι t ι (>H ι ι ι ι ι ι>ιaB x aa H H^ < H><ωωwωκwωwaahHaaaah4ιi[nnnoικt(iw

U t3 U U t5 U t5 ⁽5 U t5 t5 U EH ^ EH h EH ^ EH ti H E< H ti H h H H U U U U U U a d a a j a a il < « < < U O t30 ; < i< d CM d d CM CM d CM d CM d CM tf tf a cj Ω Cxi fai tf a cj Ω ω Ω ω co a tf acjcj tf ao tf acjΩΩ tf a tf tf a J Ω Ω υυozυυυυoooozoυooυoυυooo υυoooozυooυcozυυυυυυozυoυo uoozυυυoz υ

H Φ o w o N tn iϊ in - h oo m o ιn σι w m m o o o o oo o o o o H co ro

00 rH se o 2o2o2o2o22oo22o2oo2o2222222222222 2 22222222 222222222222222 222222222 OOOOOOOO O O O O O O O O O O O O O O O OOOOOOOOO o EH EH EH EH EH EH EH EH EH EH EHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoo22222 H EHoEHoHoEHoEHoEHoH H H EH EH H EH H EH EH EH EH EH EH H EH EH H EH EH H EH H H EH EH EH EH EH EH H EH EH tftf tftftf tf tftf tftftftftftftftf tf tftf tf tf tftf tf tf tftftf tf tf tf tf tf tf tf tf tf tftftf tftftf tf tf tftf tf tf tftf tf tf tf tf tf tftf tf tf tf O

Tf Tf t _J oo CD cT) rθ M3 r~ ι cn r^ co o o ιn "tf co ^ o cM "tf i c d CD θ in r~ ∞ o ∞ ιn i ι cN CM '^p co cN in cD σi M

Ti ∞ c θ cn r~ r-~ ι oo oo t~ ιn o r~ -^ oo o θ "tf σι crι oo ι oo oo ∞ cM ∞ rθ 'tf in 'tf c r~ d co r^ cn o cθ 'tf 'tf in r~ w

CJ s C d d 't_f M O 't_f c c c co 't_f 't_f cri oo oo o σi d M ^ in r_^ 't_f r M in r cD r_^ CM CM o i -^ in in co in D D r^ β _CN _CN CM CM rO CM CN d d d d d d d d d d d CM CM CM CM CM CN CN CM CN CN CN CM CM CM CM CN CN CM CN CN CN CM CN CM CM CM CN CM OM CM CM CN C^

CΛ

O_{O O O O}OOOO_OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO CJ d d d d d d d d d d d ρ- co cn rθ ' ^ cN r-- CN -> rθ -> co rθ "tf d _> oo o ιn o cN cn d CN cn <M cn cM cn d d CM tn co _> cN d cτι oo cD r~ ιn f~ co oo r-- oo D OT cM 'tf r^ c^ d d o oo r~ θ d in 'tf θo cM o oo cM θ CD r~ ιn c ιn ι r-- oo r^ o w co cM o r_^ (M O\ o oo in cM cn o cM co co co o cn r~ co o o cn co r-~ co cn d CD 'r cM CN r-- -> O d d r^ oo oo oo r-- oo d 'tf ^

CN d O O d O O d CN rO OO OO CN CN d CN CM OO -tf OO •^ ro rθ "tf d ιn ιn cD r~ cn oo oo oo cn σi (i5 θo oo r^ -' r~ o θ d CM "tf «tf θ ιn ιn "tf CM CM ro oo cM θ 'q' in 'r I

•t_f r~ r~ C r~

CN cM co "tf CM CM θ ιn r~ r^ oo en iD co iD io co ιn r--- oo -w oo oo cM CM oo o o σι oo r^ oo cn co cn oo cn o t^ co cD co ιn ^ cM 'tf M 't_f "tf "tf "tf "tf "tf -tf "tf ^ ^ "tf "tf _'^ ^ 'tf ^ 'tf 'tf "tf "tf "tf ro r ro ro o oo oo o oO "tf Co r ro ro r r r oo ^ o ∞ "tf t^ cD -^ co oo co cM oo cM cθ d o o o o cM r~ CM ro o 'r OT Co ro oo oo D ~ d θ θ c oo D o oo c θ ro o rι θ '» cD r^

^ o tη v d (rι ^ ιη ^ ^ ι o - n N ιn n d o co ιn n H ιη ι ιn ^ Φ c^ι ^o ^ n H ^ H ιn (Λ 030 ^ o ^ ^ ^ l ω ^ ^ oo ^ o co a oo co ^ r H (η ι (η Φ oo <^' P^ ^ 'l' ^ σι ω Φ ^ ^ ^ c^ N σι o ^ o ^ ln ιn rn o f O tη ^ H tn H n ιn tη ra ιn w ω <Jι _ ∞ Φ ιn tn d Φ H H O N fll ι ^ ω ^o o d d O O O O d d CM rO ^ rO CN CN rO d d O O O O CM CM CN O O d d O O CN OO CM OO 0000 CM ro ro ro CN o in co m co in m io m r— oo I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

ln z a a aaa a ω w ωω ω ω ωw x x x x DDDDDD Doaa aa aa co co co co co wco cocococoacocococoacococoa aa a aa w ω ωfaiwω a Ha Ha Hi H H H iH H Ha Ha i-i i-a ω - - ω ω ω fai ω ωω wωωω H HHH H HH H H H H H M H H MM H HH fai ωi-i ω cxi i] dlMMwwwoidHHHHHHHOUistia a a ii Hiaaatnnwwnwa aaaax a aa a a aaa aatonnt wB

CM d d d CN CM d d CM CM d d CM tf a o tf a cj cj Ω tf tf CJ Ω Ω tf ao tf acjΩΩωω tf aoΩΩωω tf a cj tf o z o υ o υ o zoυυυυυ o zυυ o z o o o υ o υ zoooυozυυυυzυzυozυυυυzυzυo o υ o υ o z υ

00 rH rH 222222222222222 222 22 2 2 2 2 2222222222222222222222222 2222 22222 222 rH ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo © ^ EH EH H EH EH H EH EH EH EH H H EH EH EH EH EH EH EH EH H EH EH EH EH EH H EH EH EH EH EH EH EH EH EH EH H EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH H EH EH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

ιo _ - oo oo

Φ ^ H Φ σι - ι ^ l N t^ v ^ n o "_l ^ι n ooιn oo ι ιn oo H ^ ^ oo "l' ι o d n o ι >» d ^ H H Φ ^ N (η ι O t txι ιn Φ N M co (N N (J ^ - ^ o ^ cn ( N ^ (! ^ N O ^ H ^ ιn m m d "f v H ^ ri ^ o ιn Φ σι n (ι ^ (!l ι ^ ω m ^ ω ^ "ϊ Φ Φ ri cD Φ Λ ^ ∞ H ^ O 'J (Λ eo ι ^η « « ιn ri cn (o ι-o iD ιn D 'tf in 'tf «tf CM 'tf CM in ∞ o r^ p-) co co cD cτι iD σι r^ σι σ^ d "tf in d iθ (^ oo "tf αD D d cβ in 3 'tf oo ^ co ιn "tf D D CD ιn ιn «tf o 'r M M cθ 'tf [~ co cD r^ cD r--- oo co r~ D cn cn o o o cn o cn e oo c r~ o o d CN c ro ^ d d d d d d d d d d d d d d d d d d d d d d d d d d d CN CM CM d CM d d d d d CM CM CM CN CN CM CM CM CM CM m m in in m in in in in m in m in LO o cD C d c» θ "tf ro o o -^ cn d D ι ) r~ oo cn c oo cM d o cM (^ o o cN CM in ^ r ro c ro r c u3 o ιn cn ro o cM "tf r^ ιn o cM <M

<» N Ol ^ ιn ^ H ι ιn ln ^ l^^, m m o m ιη ιn o ιn ^n H m o ιn H ^ (n o ιn Φ ι ^ o π ιn ιΛ ι o ιn ιn d ι Φ ( Φ m N O tIl r- d ^ ⁽Il ra ι ^^ lJl r• o (Jl H (!ι Φ Φ ^ o n ι ι o (η Φ O d ro tD - ι 'ϊ 0 ^ ^ o ^ o N - ^ ιn oo o3 ^ cι ιn "^ ^ ^ - - co "^ ln o H m ^ ^N ι _ ^ (Jl - rι o co t~ r~ ιn 't_f o c CM CM co cM d d o D CD ιn ιn co ιo -- r~ ^ rθ 'tf C CM CM θ CM C c CM Co o cn o c cn cn c c^

CO _CM CN CM CM CM CN CN CM CN CN CM CN CN C CM CN CN CN CM CN CM CM CN CM CM CM CN CM CM CM CM CM CN CM CM CM CN d CN d d d d d c ^τ σ> o r~ cn in o (Λ oθ 'tf co oo t co o o D o oo D CJi cN CD θ r^ cD r^ ιn c» M co ι σ^ σ) o cn r- 'tf θ ιn Λ (^ co co o o - r^ "tf θ ro r ι d in cD co d ∞ c o cM CN co _> ιo o c ιo cn α- CN cn "tf 'tf ro c ^ c^

Φ o ι ( ri f ιfl ^ o - W W ιn ^J "f - oo H O l H Hf N Φ ^ n O 9 al (η M - - ^ ^ ιnffl N ^ O N ^ H m o tΛ H ω o N O - ^ M σ^ ιη ιxι (^ι ιJl 0 o (^ι m o o d W (Λ H c^ι t ri H N n 'ι^| Φ Φ "l' ^ ^ « tΛN ^ Φ Φ - co m o ω tD ω σι (Λ σι ^ ^ ^ H t ^ Φ ι ^ (^ nιn ιn N H o o H o

I I I I d I I d d d I I d d d d d d d d d d d d d d d d d d d d d d d CN d d d d d d d d d CM CM rO OO OO OO OO OO OO OO OO OO OO OO OO OO i I I I i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i

'tf 'f ' inιn ιnιnιn ιnιn ιnιn ιnιnιnιn ιnco ιo _>co cDco co co r--- r^ r^ r^ inin in in in ininin inin inin inininininin in in in in inin in in in in in in in in ininin in in ininin inin in in com cnror nro ro oo^pooom mooroc oocorooorororooorooo ooro roro m ooro ooro roro moo tf tf tf a a a a a a a a a a a a a a D D D D Ω D D D a a c_ a a a H ι-a Ha H H Ha H D D D D D D D D Z Z Z Z Z z z z o j cj cj cj EH Ha i-a Ha a a a a a a a a a a a a a a ω ω ω fai cxi i-i ω w a a a a a a a tf tf tf tf tf tf tf ω ω w a w ω ω M a co co co co co co co a a a a a w i EH fH fH h h H EH EH H H EH tH tH H i^j a a a j a a a H EH H H tH EH ti > > > > > > > H4 a a a a ^j Hi a «; rt; «; fl; ⁽⁽; 4; <; s

CN CMCO d d Oi rOCM d CM d CM d CM d CN d CM a tf a o Ω ω w ω o o a tf a CJ Ω Ω tf a CJ CJ tf acjcj tf acjΩΩ a CJ Ω Ω tf tf o υ o z υ υ υ υ υ υ υ z υ o υ o ozooυυυυ o z o o o o o o z oυυυυozoυoυυυ o o υ o z o o o z υ o υ o z

00 rH se rH 2222222222222222222222222222222222222222222222222222222222222 rH o HoHoEHoHoHoHoHoHoHoHoHoHoEHoEHoEHoHoEHoHoEHoEHoEHoEHoHoEHoEHoHoEHoEHoHoHoHoEHoEHoHoHoEHoEHoHoEHoEHoEHoEHoEHoEHoHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoH © tf tf tf tf tf tf tf tf tf tf tftftf tftftf tf tf tftf tf tf tf tftf tf tftftf tf tftf tf tftf tf tf tf tf tf tf tf tf tf o

cM OO OO d 'tf CN d d CN OO OO d 'tf CM CM CM CM CM CM CM CM CN CM rO rO oooooooooooooooooooooooo

o t N n d d σι H (Jl - ( ιn N ^ "l' m ^o ι 'J W Φ (Jl (^ι ^ < <^ ^ Λ n H o oo ιη o H Λ ^ m σ; o l H ( O W ^ ffl n cD _ « t o c H O (^l ιn( ^ ^- o cθ "tf D θ o c~ o co d σ3 D ro p~ d r~ cD r co cN in σi o d oo oo cM cτι oo r^ ιn αo cN o r~ ^ 'r o ιn o r-- -^ -^ o ∞ ιn ' ∞ cn ro oo co cN ^ -> 'r r~ d cθ 'r o cN r^ ιn ι r--- o ι o ιn r~ 'tf ro -r co 'r o co cN cn co r~ oo oo oo r~ cn o co en o r~ co cD in "t_f CM 't_f "t_f 't_f "t_f ro ro cM d CM co d d CM O cn cn r_^ r-- r~ cn cn r~ r_^

CM CM CM CM CM CM CM CM rO CM CM CO CM CM CM CN CN C CM CM CM CM CM CM CM CM CM CM CN CN CN CM d d d d d d d d d d d d d d d d d d d d d d d d d d d d d i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i

"i' i»'i' ini i in i in i in i in inin in i - - ιnιn ιn ιn d d d d d d d d d d d d d d d d d d d

EωH EH H EH HωH EωH OaO O O O O O π Hl Ha -l Ha Ha H tf tf tf tf tf O t tf tf tf tf _ O _ O _ O _ O _ O _ O _ aaaaaaaaaaaaaaaaaaaaaaaaaaaa 22ωω2ω2ω222aaaaaaaaaaaaa tf f πa >>>>>> ³> ^a5L]g aa ^"a ^'aaaosxxxxxx tf tf - a a a a a a EH EH EH H EH EHxHxHxEHxEHxEHxEπaEHaEHaEHaEHoEHsoEHsoEHsEaHoEHsaEHaEHaEHaEHaEHaHaEH d CN d d CM CN CN CN OO d d CM CO CN tf a c Ω i Ω tf a CJ tf a cj o tf a Ωtf acj tf a ΩMΩωcoa tf acjΩwwΩωcocoa tf υ υ υ co υ υ o z o o u o υ o z υυoυoozoυo zoυoυυozoooυυυυυoυozυoooυoυzυυυυozυ

2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

ι r- ιn ιn ιn r ιn 'tf Cθ io cD ιn oo oo oo oo o o oo o d cn co r^ c o co c o3 θ d cN CM d CM d cθ "tf θ (^ rθ "tf in 'tf "tf n o cM c i ^

CM CM CM CM CM CM CM CM CM CM CM CM CM rO OO CM rO OO CM CM CM CN rO CM CN CM OI CO rO C OO CO rO rO OO OO OO OO rO OO OO rO r^ ιn ∞ 'tf in cn cn ∞ 'r ιn cN o 'tf in oo oo "tf co θ ' ro cn r- ιn cN oo o cN in ∞ _> co oo rθ d oo u r~ d ιn θ "tf r~ D ro cM cn co cn r^ cθ "tf θθ CD CM r-- d CM r~ σ^ d CM CD ro ^ ιn cN ιn ιn c co oo d in d θ co d -tf r^ σι N ιn ιn o oo f 'Φ H ^ O (D ^N N ιn∞ "l^, H ^ N ^ H n n m ιn H mΦ o o ιn ^ ιn Φ « (^ N ^^) ιn - H oo ^ * N n H H O Offl Λ tJ^ - ^ ^^ m o Φ

^ iD -tf CM CN d o o cn cn cn cn o cn cn o r- r~ r~ in in in in co cD r~ vD CD r-- r~ oo o cN CD CD in ^r ro ro ro oo oo cM CM CM CM CM in "tf in in ro ro CM d 00 o d d d d d d d d l I I I d l I d l I I I I I I I I I I I I I I d d I I I I I I I I I I I I I I 1 1 1 1 t i l l 1 1 1 I I I I I I I I I I I I

^φ - - u) i iun) inιn ιn d d d d d ro oo oo oo oo aaaaaa aaaa aoooooootf tf tf tf tf tf tf tf tf tf HEHEHEHEH HEHHtf tf tf tf tf co co co coco co co co eo I tf tf tf tf D D D D D D x aωωωi.i.i.i.i-iii^i-i-i.aiJdaiJdaaaiiωui-i.i.i-Eiii-aiJHi πa ,_l X X X X X X X X X κa π ι-i HH fai fai w fai ^χi -1 EHEHEHEHEHCocococoacoaaaaaaatf tf tf tf tf tf sctf tf tf 22222222tf tf tf CC ^ Hl Hl Hl πl Hl Hl Hl i Hl ! tf tf tf tf Ha ι-a ι-a H ι- H d CM d CM a CJ cj tf a CJ Ω tf a cj tf tf a tf a cj Ω o tf a tf a o Ω a co tf a tf a cj Ω Ω o o υ υ o z o υ o o o z υoυυυozυoo o z υ υ υ ozoυυcoυooz υ υ υ o z υ υ υ υ υ z υ o z υoυoz υυυυo ininin ininin

00 rH

* roH 2222222222222222222222222222222222222222222222222222222222222 rH o EHoEHoEHoEHoEHoEHoEHoEHoE oo © EHoEHoEHoHoEHoEHoEHo H H EHoEHoEHoEHoEHoEHoEHoEHoEHoHoHoHoEHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoEHoEHoHoEH o tftf tf tf tftf tf tf tf tf tf tftf tftftf tf tf tftftf tftf tf tftftftf tftf tf tf tf tf tftf tf tf tftf tf tf tf tf tf tf tf tf tftftf tf tf tf tf tf tf

oooooooooo oooooooooo ftπ co o d oo

CD oo d o

_"tf ιn n c!l n oo ro oo ooco oo ro ro ooro oo oo oo rooo oo ro oo oo oooooo noo oooo rooo oo ooro oo oo nro oooo n ro oo ro oo M

Dowcowcococ cocococotf tf tf tf tf raH πai- HiH Haoooooootf tf tf tf tf tf aaosaa osa πa J HI HI ω ω M M M M M H M H d i- Ha Ha Ha Ha tf tf tf tf tf tf tf a a a a a a a Ha Ha H H Ha Haaaaa a . tf, tf, tf, tf . d tf tf tf < πa Ha a a a a a a a a a a tf tf tf tf tf > > > > > > > a a a a a a a tf tf tf tf tf tf EH EH EH H tH EH EH > > > > > > > tf

CM d d CM d CM d CM d CM tf a CJ Ω Ω Cx] fa] oozυυoυzoz tf a tf acjo Ωtf ao tf a tf a tf a tf acjcj tf a o CJ υ o zooυozoooυυozoυυooozυooo zoυυozoυυozoooυoo o o υ o o o z

- oo ri - ιntn ιn ιo

CO CO CO ^CO r~ co oo oo oo oo

00 rH se 2o2o2o222 22 o22 2 22 2222 222222222222222222222222222222 O O OOO O O O O OO O O EHoEHoEHoHo2 Ho2 Ho2 HoHoEHo2 EHo22 22 EH EoH H EoHo2 Ho2 EHo2 EHo^oEHoEHo2 EHoEHo22 Ho O O O O O O O O O O O OOO O O O EHoEHoHoEHoHo o H EH EH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf rtl tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

to d -l ooo ooo ra ₉ M Φ O (^^ o ι d - "^ t (l^ M O ιη ι5\ o ^ m ffl H o tη Φ O 'f d n(^ι ι M o ra M O (η o ι o - ^ (Jl H ιn o ^ ^ ^ ^ N "^' Φ - ( '!^ d

"tf "tf oo ro oo r~ c o [^ cn ιn cD in cM σi cD oo r^ «tf "tf cn cn r^ d d co crι ιn «tf in r--- o D r~ d c ( ro <η ^ o o ^ Ol ιn ^ H 9 ^ t» (!l H ιJ ιn 'r ^ co "|| 'f ^ n _ αι t^ ιn o ιη H Hl^ι M Φ co c^ι ^^ "^ 'lι ^B Φ σι ω H l Ol co (!lco ιn ^ Λ '* ^ - 0 (^|^ o ιD

CD io r- r^ ∞ cn cn cn cn co oo c^ oo o θ d CM CM ro -c' -^ ιn cD co ιn ιn cD CD r~ r--- cD oo σ\ ∞ cn σι cn o c^ r ro ro r o co c^ r o o r oθ "tf 'tf 'tf '^ 'r ^ ^ ^ -'r '^ "tf ^ 'tf ^ 'tf "tf ^ 'tf 'r 'j' 'tf ''r 'tf 'r ιn "tf tn ι ιn ιn ι^ D O d σl ιn m - Φ ^ ^β ln ι ^ r• <o r- co ^- ^ d (η Ol o S C

ιn ιn ιn ι - Φ Φ - Φ - Φ . - Φ Φ ^ ^ ^ ^ ^ ω oo ω eo ω(» trι σι n m (Λ Oι (Jl o o o o o o d d H H M N ι c>^ σ) P1 t»l n ι»l nt ^ ^ ^ ^ ^ r~ r~ r~ i^ r^ [^ r_^ r_^ r~ r~ r~ r~ r-- r-- r^ r~ r-- r--- r~ r^ r--- r_^ [~ r_^ r~ r-- r_^ d d d d rl d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d co ro ro i^ ro ro ro ro ro ro ro ro r n ro oo oo n ro ro ro ro ro n oo oo oo oo oo oo co t^ ro ro co co co ro ro ro r oo r^ tfa f i bi bi ci faxi ωx co co co co cocooooooooa a aa a aaaaos a a x xx x aa a a aosaoooo o tfatf tf tfa xi fai a b tfat tfaω c aaaxaaaaaaxaaaaa x xx xx aa a pS os aaωfai i-ii-i txi wcifaiωfai ωω H Ha H Ha aa a B a a aa a o ooooϋ a a a a a a acocococococococococococo cjcjc c EHEH EH EH EH EH EH a a a a c-i d CM d CM d CM tf a tf a cj Ω Ω fai fai co tf a tf a ø Ωtf ao tf a CJ tf ao tf tf acjcj Ωtf acj oooozooooooooo o z oooozoooocozooooo z o o o o o z oooozooozoooooozoooo r~ ∞ c o d CM (^ 'tf in cD r~ oo c θ C ro ^ ιn cD r-~ ∞ n o d CN r ^ ιn co t^ ∞ σ^ θ d CN ro ^,^ Ln cD r- oo cn o d C o 'tf d d d CN C CN CM CN CM CN CN CM CM c co r ro M o r "tf "» "tf 'tf 'tf ^ 'tf 'tf 'tf "tf in ι ι ιn ι ιn ιn ιn ι^ r~ r^ r^ r~ r~ r~ r- [--. r^ r~ r~ r~ r^ r~ r^ r-- r-- r-- r^ r~ r- r~ r-- r^ r~ r^ c n co ro oo co oo ro ro ro oo oo oo oo ro oo oo oo oo oo oo oo oo oo oo oo n oo ro oo oo r n se

222 2222 22222222222222 22222222222222 222222222222222222222222 OOO O O O O OOOOOOOOOOOOOO OOO OOOOOOOOOOO OOOOOOOOOOOO OOOOOOOOOOOO

© E ^H E^H E^H E E H EH EH EH EH EH EH EH H H EH EH tf tf tf tf tf tf tf tf^H Etf tftf ft^HtfEH EtfH EtfH EtfH EtfH EtfH ItfH EH EH E tf^H Etf^H tf tftftftftftf tf tf tf tf tf tf tf E tfH EtfH EtfH EtfH EtfH EtfH EtfH EtfH EtfHtfH EtfH EtfH EtfH Etf^H EtfH EtfH EtfH EtfH EtfH EtfH EtfHtfEH EtfHtfH

O

<N r~ ooc cD ^ro rovo o cnr~ σι o c o ror ι r r o r~ 'tf "tf r^ ιn oo cN r~ ocM ^ d oo 'tf r^ ιn d cM dcη ^ rO ■* r-- cnroocorooooocD(^ Dσ^ι c co D in ιnco tncΛ ^ c_N CD in r~ -) ro oo r~ ι c~ ^ ocM -^ 'tf θ r~ oocD ^

CJ

© r _d inc_{D d} σ^ _{d C}M in r_^ "_tf ^ ιnιn 't_f DiD o cyi c _d c o c oo _'^cn oo cD in ιn coιn 'tf c r~ cD ∞ d oor~ o ∞ © 3 _{CM CM CM}C_M COrO 'tf 'tf C_M C_MCM CMCM CM C_MCN CM CM d dCM d CM CMd d d d d d d d d CN CM CM d d d d dd d d CMCMCM CM CM CN CM CNCM CO rOOO

CΛ ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo CJ ftπ d d C ^ c ι -^ _> r~ ιn ^ ro r-- _) r-- r^ ιn r-^ o ∞ cx>r '^ r-- deN r~ ocN C^ o^ t_D W ^ O ( d ι m N d "J _N O (Jl^ ι Φ(η ^ [Dd d d - m N ^ m - Nι d t <J (ηeo co (η^d αl (\l - ιn ^ ' 0 ^l ^^ o * 'tf in r o cN r~ cn d oo cN CΛ r^ ιn c ro o d CD r cMoo r oo r-- Ln θ '^ o e σι σ^ oo d CM ∞o c c cD ιn o ιnαo ∞ cn 'r r "tf ^ cMCM d ocτιoor~ ooσ^ <^σ o cnoo oo ρ- r~ cDco ιnιn ιn cθ 'tf 'tf ro rocM CN CM d rocM CN CM CM θθ oooo o o cn o dd do cno o dCM ro dcn cn co co ιnιnι ι <tf "tf "tf "tf 'tf ^ "tf in -^ ι ιn 'tf _"tf 'tf 'tf 'tf 'r "tf 'tf 'r Hr 'r 'tf 'r "tf ^t 'i^, 'tf ^r "tf "tf "tf 'j^, ^r "tf rθ 'j^l "tf "tf 'tf "tf 'tf 'tf ^i 'tf rθ'tf ^,'j* τ ^r 'tf ^rr r r o

« Hf inιnιnιnιnιnιnιn . ΦΦΦΦ r- r- c-c- c-ι»ιj)co(Dcot»cocooιoι ιoi(rιo ooooooooooooodd ridHdHd( (\ι co co co ∞ oo ∞ ∞ oo oo oooo ∞oooo oo∞ oooocD∞oo ooro ro cDOD Oooo oooo ∞ oo ∞ ∞∞ oooocn cn cn cn d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d oo ro oo ooro rooo oo ro oocorocoooooro rooooooooorooo oooooooo oororo oooo ro rooo roro rocooo oo o o z z z z z z z zo oooo oo a aaaa aoSDDDDDDD D tf tf tf tf tf a a a a a a a aa aaaaaDDDDD DDDcoco a a co acococ c coco a a a a a a a a a a a ω xifai xiω faiw ωHaHaHa Ha Ha a a a a a a aa a a aa aaω ω ω u ω ω ω ω x x a a tf tf tf tf tf tf tf tf a a a a a a a EH EHHEHEH EH EH HaHaHaHa Hi HaHa Ha tf tf tf tf tf H EH EH EH EH H HEH H EH H EH H EH iH Ha H Ha Ha Ha Ha i-a H Ha d CN d CM d CM CN CN OO d d CN OO CN d CM tf a CJ Ω Ω Ω tf acj tf aocj tf a J Ω Ω tf a tf a cj Ω fal fal Ω txl co cO B tf a CJ Ω Ω tf υo z oυυo z υ o υυυυ υo z υυooυoz o υ u υ υ o o z υ o o o zυυoυooozooυυo υυυυυυozo

00 rH

2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo tf tf tf tf tf tf tf tf tf tf tf tf tftf tftf tf tf tf tftf tftftf tf tf tftftf tftf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tftf tftftf tf tf tf o

∞ oo_/oo_.ooooooo-'oo-'^o_-oo_< oooooooooooooooo d d dd d d d d d d d ι»oι ιnn-ι πnoo3^^ι _Hlncooιno ιnt^ιnΦoιnoΦΦOιJιιn <^ln(ηN^ σι'fc^ιoo■»N^^oα)Λ^ιnfl_'^ιnσιH_ cD in -tf oo oo oo oo oo oo ra r- oo co o o d cN d csιo (Jlω σι w ω oo ω ^ _ ^ ι - ιn ιn n^ _'a' l N m ιnt>l o^ N N H H H O o o m ∞ co ^- ^ r- oo ^ ^ c^ι co oo ro ro ro oo ro ro ro oo ro ro ro τ 'J" 'tf "tf 'tf 'tf 'r ro ro t oo oo oo oo ro n n ro oo ro ro ro n oo ro n ro ro ro ro oo oo oo oo oo co cM CM CN CM CM CM CM CN CM CM C^ o θ 'tf r^ M CD r~ oo d io oo oo -tf C θ ιn o r~ r^ ro vD D 'tf ∞ ιn ι o θ 'r 'tf r^ cN c^ d < θ CM θ r~ c r "tf ^ oo ιn r-~ r oo cM CD d cM θ c^ c cD <τι d 'r d in cM CD D cyι o cD to σ^ D o ^«tf θ ιn "tf oo cN CM d o cM d i "tf 'tf i ^ oo co ι cn c^ cn ^ c» r~ oo ιn 'tf CD CM ιn d 'tf oo θo o θ 'r io ιn o d cθ "tf '_J" θ c^ co ro D cN θ d r~ oo θ "tf CN cn o oo ι c C o cD oo ^

^η ^ (η p '» ιfl φ ιn c^■ tI! r• c■ ^• ^ o ^ ^ ^• c• r' oo ^£l ιn ιtl HP lJ ^ « ( ^l d d O N βι d O d O d H d O ^ ι^ι co r- ^ Ol O d d o l H ^ι (»l ^^ '^ "tf '^ 'T "tf "tf ^,^ ^,') "tf '^ "tf ^r 'tf '^ ^ "tf ^ "tf ^ ^,tf "tf 'tf "tf 'tf "tf -^ 'r 'r 'tf "tf ^ 'f 'tf "tf -^ (^ "tf '^ "tf '^ ^ 'tf ^

Ln o n c co t~ cM o r^ cM ^ crι cD σι cM in o r-- d r~ CD oo ^ M d C σι o r^ "tf i-o r-- a r~ r^ cM ∞ co r^ d cn d CN CD ro r~ co ro oo d d (M Cθ CD oo oo c^ cD σ^ co cn o ro cD σ o co ιn oo oo ιn cD in σι oo cN d d d co d d ro ιn co cM ∞ o r~ rθ L^

"tf d CN 'tf c^ d σ^ o oo e cM CM ro θ '^ D oo d d c in ιn cn o d in d oo ιn cD Λ co _ o ιn d r~ o oo o '^ f i "tf i o r-- oo D ^ ^ φ ι ιn '» (N - - ιn ^ ι^ι (η N tηφ φ φ (!l o ol o o o o ^l N ^ H d o m oo _ 03 ^ ^ ^ d H t^ι n "f l d c^l (η H r π H O c>^ (^ι ^ ι ι ι r^ d C d d d d d d d d d d d d d d d d d d CM d CM CM CM CM CM CM CM CM C CM CM d d d d d d d CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C CM CM CN CM CM C I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

cM CM CNCN CN CM CMrocoro roooro oooo -r - 'tf "tf in ιn ιn ιn ιnco ιθ -> -> -> r^ cn cn cncncn -ncncncncn cn cn cn o^ cn cn oi cn oocn cn cncn cn cn cnoi i^ d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d dCM CM CNCN CN CMCM CN CM co ro ro rorooooo ooro ro oooo oo ooro ro oo oo oororoco oooo noorooorooooo n oo oo n co co co co co co co Z Z Z Z Z Z Z Z X X X X tf tf tf fttf t t o x x x x x x x co c co co co co a H Hi i- i-i i-a Ha H . , j tfa a atf fJ πtfi aωωa awaaωωxωϊ aωaωaωacxiJtfjtftfatfd dfooioBi Kiouoαi ioiuoβiato taonananaatn raaMacHo

,_i Ha Ha Ha H Ha Ha tf tf tf tf tf tf tf tf cj o j c tf tf tf tf tf tf tf ^' tf tf tf a a a a a a a a a a a tf tf tf tf tf a^" a - a - a - a - a - a - tf "tf ~tf "tf "tf 'tf 'tf ^*tf 'a d CN d CM d CM d CM a o Ω fai o tf a cj Ω Ω tf o z tf a tf a tf a c Ω Ω Cxi fai co tf a υυoozoo Ω tf a cj tf a cj Ω Ω o o o o z o zoo o z υooozυυoozoooooooooozooυo z υ o υ υ υ o υ υ υ o o υ o cn o dCM ro ri_Jo _>r-- CD cn od rMrO'tf inco r-- co cno dCM Co «tf tn co r~ cocn o d rθ '^p "tf "tf 'tf "tf 'r "tf ^«tf "tf "tf in ιn ιn ιn ιn ιnι ιnιn ιn _> _> β io ιo -ϊ _> ι^ oo co oo oo co oo ∞ ∞ ∞ oo oo oo cooo oo oo∞co∞oooo∞ ∞a ∞αo oo ∞ ∞ a ∞ oooo∞co∞ ∞oooo oo∞ oo ∞ oo ro oo ro ro ro ro m ro ro ro ro oopo ro ron oocomcoro oooo oo n m oo r oo m

00 rH

2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo o tf tf tftftftftf tf tf tf tf tf tf tftftf tf tftf t_f t_f t_f t_f tf tft_ft_ft_ft_f t_ft_f tft_f tftf tftft_f t_f tf t_f tf tf t_f t_f tf tf tf tf tf t_f

f

o o d ι σ^ ιn 'tf θ r~ CM d co cM c o o σi d co d ro cM ro ιn o <ri c 3 d oo r~ oo oo d θ oo ιn r~ ro o (-Cι CD cM CM in oo cD r^ ιn ιn cM r~ Lθ cn d oo ' Lθ cn -- '_ ro ιn cn d cn rθ "tf ro cn r-~ o cn ιn c θ cθ 'tf cn ' θ r^ ιn o oo oo ιn ro cM co cn cM in ιn o co θ '^ co r-- -tf "tf 'tf CM d cn cD oo oo cD ro ra cn <τι r~ co cn cM CD ~ -. ι_ι ιo ιn ι^ σ^ d d cM d CM ro co oo oo ι^ oo cn σ^ σι oo oo r~ iD D ιn 'tf cθ d cN d 'w ιn "tf 'r ιn ιn D r~ oo cn OT θ d cN o "tf CN cθ 'tf

CM OO OO OO OO r OO CM CM CN CM CM CM CM CM CM CN CM CM CM CN CN CN CM CM CN CM CM CN CM CN CM CM CM CM CM CM rO rO CO I^ M

CN σ ιn r~ ιn ι Φ d f (Jl ιn m t "j ιn "f Hm H H θ θ H d (η moo _

o τι d d cM r cN θo oo co r-- ιo co ιn 'tf <^ 'r cN r^ c» <_> cD ιn cD io ι θ Ln r^ co r~ oo oo c co r~ α^ co r^

CM d CN CM CN CM CM d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d CM d CM CM CM d CM d d d d d CM CM CM CM CM CM CM d I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

d d d d d d d d d 0M CN CN CM CM CM CM CN CN CM CN Cθ eθ ro eO 000O 00 O0 "tf -r 'r 'tf ιn ιn ιn ιn iO lO _> lO l^ ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ro ro oo oo oo oo ro oo oo oo ooro oo oo ro ro oo oooo rococoroc ro roro roro oo oooo oo ooro oo ooro oooo oo oo oo ^ co coco co co oco co co oo o o o ^jc^jc^jc^jc^jc^jω wω iωwωω x x x x xx x a aaaaaa a aaa tf tf tf tf tf Ha H H H Ha H Hatf

H M HH HM HM H aa aaaΛaa aos a Ha H iHH H H iHH Ha Ha i-i Ha H H Hi H xx xx x xxx H H HaHa H tf tf tf tf tf tf tf a a a a a a a a a tf tf tf tf tf tf tf tf tf tf tf M M M M H M Ooo jcj o EH EHEHEHEH EHEHEH EH EHEH H tf tf tf tf tf > > > > > > tf

CM d d CM d CM CN d d d d CN CM rH CN tf CJ Ω Ω fa] fa] tf acjΩiacoa a tf a cj cj Ω tf tf tf oΩ xiΩω coffi tf a tf acj cj oυυozυzoo zυυυozozzooz υouoooozυo ozooozυυυoυυυuoυozυυυozuυυυυo

00 rH se

222 2 2 2 22 2 222 2 2 22 22 22222222222222 2 222 22 22 2222222 22 22 2222222 222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo tf tf tf tf tf tf tf tf tf tftf tf tftf tf tf tf tf tftf tftftftftf tftf tf tf tftf tf tf tf tf tf tf tf tf tf tf tftf tf tf

O

- θ H(rιι

ooooooo ooooooo ^ ^ '_l' ro Φ "_f ω N ^ι Φ cl Φ W ^ o ι ιn ιn fll (^ ^^ ^ N C H ^ (ι o ^ ω ^ o n o (^ι o tη fl Φ H ^ ω ri ω ■τ ^ N N t^ o o H m '^ ιn '» ^ o ^ ω tη oo cD D 'tf CM CΛ (yι oo ro cD crι [^ CN e co o 3 CN θ o ro c co oo co cM 'tf ^θ 'tf θθ "tf r~ r--- ∞ cn cM CM '^ n H ra H ^_I "t Φ M ι N 'ϊ H r^ n ιn Φ tn '^ Ol O d ιn ι^ϊ^ ιn ^ o o ^ W lI t^,ι co v co ιn ^ι ιn H ^ (D Oιn ^ m σι oo (c W [^ι ^ H H (o

^ ^ ω <n m o o m m ^ o ol (D ^ ^^ O H O ιn o σι o M ^ W N 'l' ιn ^ ιn ιn I l N O O ι3^ (!l oo (lo fl Φ ^ ^• ιn ιn ιn 'J (') (^,l N ^ c r o o 't_f 't_f r o r ^ r r ^ "tf 'T 'tf 'i^, 'tf -^ 'tf 'r "tf (^ 'tf -'^ ^ 'tf 'tf "tf "tf "tf "tf 'r ^ 'tf 'tf "tf -^ "tf ^ 'r

't_f CM CD ι d "t_f d r σι co o r~ σ^ σι to "tf τ oo rθ 'tf CM "tf -> <^ d co ι r^ ∞ crι ^ o o θ co r^ o cD 'tf co r^ d ∞ co ιn ^ c i-^ r d t^ co cD ro cN -'r oo ∞ D in ^ r^ in r^ O d ^ oo d oo 'tf oo D CN i oo oo o in cD O '^ oo oo c cD i^ 'tf D d ∞

H (N W d ιη tη 'f ι σl o m (Jl H M OOJ O Φ ω o ^ ^ n "l^, <D ιn ^ H •J tη o r ln ^ p^ N O H mΦ (^,1 ιn( (B t^, ιn ^^ι o o c ιn o oo H

^ Φ ^ ^ ^ ^ m oD m c?^ H O H Φ Φ ιn n N "f n M^| ιn 'f (η 'f Φ ^ ω o^ ^ cD ^ σl Φ Φ ^ tJιω (Λ Ofll o <Λ ^ o o H N ( ^ "l^| ιn cι l H H O (Λ cn

CM CM CN CN CM CM CM CN CM CM CM rO rO rO CM CM CN CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM r^ m N N H c» _) cN

cn en cn c^ o o o o o o o o o o o o d d d d d CM CM CM CM CM CM CM ro ro ro oo oo ro ro oo ro ro oo oo oo ro 'r 'tf -sr -tf 'ti m in m m in m in m co cD CD CD iD

O O O O d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d CM CN CM CM CN CM CM CM CM CM CN CM CM CM CM CM CM CN CM CM CM CM CM CM CN CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM co co oo ro oo ro m oo oo ro ro m oo m oo oo n co oo oo o n n ro ro oo oo oo oo oo oo oo oo co co co oo ro co oo ro oo ro oo ro ro tf tftf tfaaaaaaaaaaaatftftf tftf aaaaaaaaaaaaaaaaaaaaaaaaaaaaaa xiuωaabiaaaa H tf Htf Htf HtfxEH EH EHxEH EH EHxEHxEHxEHxEHxEH -xHHtfHtfHtfHtfaHtf a EH-aEHa - EHaEHaEHaEHaEHaH EaHa -EHaE-Ha-EHo-EHsaE-H Ea-HaE-HaE-πa-EHa-EHa-EHaE-HωCOwCOcCiwC wCOωCOH H HMHMιH-aHMaHHaHHaH H H ι-iHa d d CM CM d CN CM CN OO d d CM CO CN CM d d CM d tfa tfaoΩWΩa oa tf a tf a CJ CJ tf a cj Ω fai a Ω fai co co a tf acj tf acjc Ω tf acjcj υooozυυoooυυυoυoz υoυozoυoυυo υoυυυoυzυυυυ ozυooυozυυυυυυozυoυo

00 rH

2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

EH EH H EH EH EH EH EH EH EH EH EH EH EH EH EH H H EH EH H H EH EH H H EH EH EH H EH H EH EH EH EH H EH EH EH EH EH EH EH EH EH EH EH EH EH H EH EH EH EH EH EH H EH EH EH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

■Si ιnt3lιn_OlJOOΦf 0300(ΛoΦΦfn^ no^o [»)u^Ol(η (Of oσl(Jl"»o^ ιn"^ol"J'ι o(^lNOW"^^l^ιooln ll O(J^Φr" o^H _"tf cnr~α3θ'tf t^ ι^ _ -^r---ooιnc CD∞^ι r~o^e c CD oDr cDCDιn_"tf oocococ c cθ"- r^ ∞oo^ιnι^ o

CJ ιo ιθ ^ ιn ιn ιn cn oo o -tf r^ cN o oo cn oo cN oo -^ d cN in (^ d cM oo d d oo cn o cn cn cn d r~ co cn oo cn σ\ oo r-- ιo σι O O (\l d ] ^ r- ^ ^ ιj ιn o ι^γ) ϊi^{, ι}a' ij

CN CM CM CN CM CN CM rO rO CN CM CM CM CM CM rO rO d d CN CM CN rO CM CN CN CN CM CN d CN d d d CM d d d d d d d d d d CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM ooooooooooo _ o_^ooooooooooooooooooo oooooooooo _ oooooooooooooooooooo

H ooooooooooooooooooooooooooooo ooooooooooσooooooooooooooooooooo CJ ft. csi d tD '» N O ι tn ^ H « N O ^ Ol ra M ι N d Φ ^ ιη ι H ιn ^ m N H H cO "J ω ^ ω m σ^ m N o o ^ w ^ι o ι ^ fn ^ (^ m cD O 'f m ιn o O H N ^ H ^ d n σι Φ σι ^ o o ^ fn (η o o ^ ι ιn Φ ιn ι r^ H 'ϊ H lo Φ l * ( ^ m ⁽Λ H Φ ^ ^ n co Φ (^ι ι ol H H ^- ^ ^l "^ ^(,) (η oo ιη ^ o ιn ∞ CM d CD r~ o en d r cn oo co M 'tf C CM r co σ "tf αD in ι cM CD ιn 'tf '^ cD Ln oo ι ^r r^ r^ o cθ 'tf 'tf tn oo cn ιn m v N H < d d N f (η o o ra ^ Φ ^ oo Φ ^ ^ Φ ι "f fn Φ Φ ^ ω σι o w t Φ ^ ι ^ ιn ^ co ^ ω ^ Φ o θ m m ^ h θ o m o o oι σι co N π r rO rO rO rO rO n CO rO rO OO OO CM CN CN CM CM CM CM CM CN CN CM CN CM CM CM CN CM rO CM CM CM CM CM CM CN CM CM CM CM C^

^■ιf ^ fll "f Φ M O O O l ! Φ Φ o ^ co ιn ι ιη ι7ι ^ < ι σι 'τ t ^ ^ (Λ Φ O ( m m ol o ι Ol Φ o n o o H co H lfl (N ιn H ι « ^^ co ^ ^ "f 0 ^ι (^ ^ o Φ Φ CD O l ^ ra π fn o o ^• ιn ^- co ^ <^' 'l^| o o m (ι ol Φ O "^ Φ ι I ) ^ O ^ ιn <» σ) ^ ι !n ol n o t^ Φ O O ι<l rl ( l tι ^ ol lJ^ ^ r• D ιn ι cN d ιn d cn cD r^ r^ o cn d co c r-~ d CM c o "tf CN CD oo r- cD CM co "tf d d Ln co ιn rθ 'r cN θ ^,tf ^ιtf 'r θ 'r c^ c^ ^ n "^ ιn Φ ^ ( tn π { ( O O w ^ ιn (O ιn ιn Φ r ^ ^ Φ ^ ω tD O H H O (N l r^ tη ^ ln ^ ιn ιn ln ιn ιn ^ ιn ι (^rι ^l O O (^rι ^ι n CM c ro r ro r o o r r t^ c oo ro r r ro r f^ t^ ro M to o ^ 'tf 'f 'tf 'tf 'tf 'tf 'r ^

T T LO rO rO OO -tf CO CM CN d rO CN CN CM CM CN CN O cn o cn cn o oo co co σi io oo r— co r- oo oo cr> r-~ co co in co r- co o d d O d O O O d CM d O O CO d d d d d d d d d d d d d d d d d d d l d l l d l l l l l l l l l l l l l I I I I I I I d d I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

Φ Φ ^ ^ ^ ^ ^ ^ (B co o3 co {D m tD co Ol ⁽^ m m m al o o o o o o o d H d d d d ι l N ^ι p^ J (^ι tη ⁽»l ( n ⁽n n ^ "P Hf ^ "f ^ ^ ^ ι d d d d d d d d d d d d d d d d d d d d d d d d d CM CN CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CN CN CM CM CM CN CM CM CM CN CM CN CN CM CN CN CN CM CN CM CN CM CN CM CM CN CN CN CM CM CN CN CN CN CN CM CM CM CM CN CN CM CM CM CM CN CN CN CM rN CM CN ro ro n ro fO ro ro ro oo rO oo ro oo n M r ro oo ro rO oo ro oo oo oo n oo oo ro oo oo ro ro oo oo oo oo oo oo oo oo oo o^ ω faiω EH HEHEH H EH tH EH a i-i a a a a a a a a aa aHa H Ha Ha Ha H H H Ha H Ha Ha Ha μi oo o o o o o a a a a a a aa aa aa a a tf πa iHiπ w cxifai ω ω ω ω ω tΛ coco coco cow co fai a ω i-iω faitf tf tf tf tf tf tf tf tf tf tf tf tf tf a a a a a a c^ fai ωωωω ωωcococow

H M hH 22222222 tf tf tf tf tf tf tf tf co co cowcoω> > > > > > > > > > > > > > a a a a a a a cococotococotf tf tf tf tf tf tf tf tf d CM d CM d CN d CM

Ω tf a cj Ω o tf a J Ω Ω tf a CJ tf a CJ cj tf a o cj Ω tf a CJ tfacj tf oΩΩ υ o z o υ υ co o o o zoυ υo oυo z υ o o o o o o o o υ o z o o o o o o z o o o o o o zooooozoυoooυo

Nn "J ln D m o HN CN CN CN

O O O O O O O O O O O

00

22222222222 22222222 22 ooooooooooo 222222 22 222 222 222 222222 22 22 22 222 OO O O O OO O O O OOOO O O O OO O O O O O O O O O O O O O o O O O O O O O O O tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

Φ -o -t' o o ftπ d d d d d d d d d d d d d d d d d d d d d (n _ H m r o o o o -^ _'^ 'tf ' 'tf "tf c 'tf "tf ( 'tf "tf "tf 'tf "tf 'tf '^ "tf «tf 'tf _"tf "tf "tf ^,'r 'tf "tf ^

in in in in co cD CD _> r^ ^ r~ r~ r~ r~ r~ r~ oo cD c» oo oo oo oo oo oo co co co cn cn cn cn <-o c^

CN CN CM CN CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CN CM CO rO rO CO rO CO rO CM CM CM CM OM CN CN CN CN CN CN CN CM CM CN CN CN CN CN CN CN CN CN CN CN CN CM CM CN CM CN CM CM CN CM CN CN CN CN CN CN C^ oo ro ro ro ro ro ro r ro ro oo ro ro oo ro oo ro t^ ro ro co co ro m ro oo co ro oo ro oo oo oo co co oo oo oo oo o^ tf tf tf tf xxxxzzzzzzzzaaaaaaaaaaaaaaaaaaa tococ a oωωωaωωωωH HaH H i- H H DDDΩ HaHaH i-iH HaHaH ocococococococoxxxxxx xxxxxaaaa aaxxxxxxiHHaHaH H HaHai-itf tf tf tf tf tf tf H HaH H tf tf tf tf CJ O CJ CJ tf tf tf tf tf tf tf tf E^H EH EH EH EH EH EH EH EH H EH EH EH EH EH EH EH EH EH O O O O O O H H H d H H M H > > > > > > > O CJ CJ CJ tf tf d CM d d CM CM d CM CM d d d CM tf a Ω Ω tf c ΩωΩfaj o oooozoooz tf a cj cj tf a o o o υ o z υ o tf a c o Ω tf a cj cj tf a c zoυυυυυυooυoz υoooυozυυooco υoυoυo o z o υ o υ o z υ υ υ

00

222222222222222222222222222222222222222222222222222222222222 oooo o

O EH EH EH EHoEHoEHoEHoHoEHoEH EHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoHoHoEHoEH EoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEH tf tftftf tf tftf tf tftftf tft_f t_f tf tftftf tftftf tf t_f t_f t_f tf t_ftf tftf tftf tf tftf tf tftf t_ftftf tf tftft_f tf tf tftftftf tf tf

O

ri ιn «N O ooooodcMCM'tf 'tf inininininininininini i i i i inininini i inini i i i i i i i i

ro n ro ro oo oo oo oo ro ro oooo oooorooo oo oo ooro roro ro ro o oooo n oo oo oor c r o o o r r r

CM CM CM CM CM CM CM CM M

o o rocθ_"tf 'tf "tf ^'^^^'tf tnιnιnιnιnco _>cD o okθ o _> _>vo o _>r~r~ oooocomoooonoooocorooooooororooooororooooooororooooororooocooororor^ roroi^roooooeooorooorooooooorooooooooorooooooooooorooororooooonrororoMt corororo

D D D D Ω z z z z z z z z tf tf tf tf tf a a a a a c-s a a a a a a x x x x a a a a a os ω ω ω ω ω ω ω cxi z z z z z z z z co co co co co 1-a H H H Ha OT o a co w co co ι^ H Ha Ha Ha x x x x x x x x x x x x H Ha ιJ Ha ii fai fai ω ω ω Ha H H Ha Ha Ha H Ha co w co co a a m c M M i-H Hi

OU UOt3 rt < < ^«< ^ (i; B B h H B h H h H BH - O UO n m⁽O M⁽Otl3 H H H H H H HH < (( ^ ; a a a a X d CM d CM d d CM CM CM d d d CM xi fai tf a cj Ω Ω tf a tfaoΩaΩw oa tf tfacj tf a cj Ω tf a CJ Ω Ω tf a o Ω ooooozoooozoozooo ozoυυooυυυoυozυυozooooo υ υ o υ o o o υυoozυoz o υ o o

2222222222222222222222222222222222222222222222222222222222222 0000000000000000000000000000000000000000000000000000000000000 tftf tf tf t_f tf t_f tf tf tf tf tftf tf tf tftf tf tf tftf tf tftf tftftf tf tf tf tftf tf tf tf tftftf tftf tf tf tf tftf tf tf tftftf tf tf tf tf tf

O

o cM CM in ^ 'tf e cn d d 'tf σι ιn cN <Λ in d CN C ^ cM i oo cM co ιn D θ Ln θ "tf cn r o N oo o r^ ιn t^ ro r~ o oo d o <N oo cN C r^

Ti oo Λ H <Jι (^ι d ^ ι H (Λ Φ ^ to o o ωra ffl ιn tI) Ol H o t n al ^ ^ o ^ ιn ^• oo (D ^P O ^ <! ^ (» '* N O (^ι o N ^ι o Hl^, ιnt ιn w (J (oo

CJ o t « N θ H θθ θi o o o o Λtη ^ ιnN n N H iη ^ to o N H n n oω ^ ιn (\i(θ N ΦN (D N r] ^ Φ 'r ι 'i^ι 'i^ι n Φ H N 'J^ι ιn H N co o o rO rO CN CN CN CN CN CN d CN CN CN CM d eN CN CM CN CN CN CN CN CM eM CN CN CM CM CN CN CN d CN d CM CM CM C^

CΛ ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo υ d d d d d d d ftπ oo (η Φ ^ (Jl Φ tn ra ιn o ιn o N d ^ (n _ ^ N ω o H Φ o ri ^ ol n Φ N o^ l o O '^ H oo [D co ^ι tι ιn o ^ 'l' ( n "^^ι <l^ι H H oo ω oo c r cM ro r o ι d 'r cD iD n ^ cM CM CM co ιn σι ∞ d θ CN in ro o o C o cM rø ri r 'tf θ r~ d o r~ 'tf (^ θ "tf oo D o ^,'r ιn cjι c^ σι io ^ oo o r_^ "t_f CD CM oo ιn ιn oo o oo o r-- c_ σ CN Λ oo d r-- r~ o ιn cD r "tf σι cM CN r-- σι o r^ ∞ oo oo r~ co ιn cD ιn ιn D 'T 'tf in ro cM CM CM r ro ro oθ 'tf "tf d d d θ d σ c oo r-~ cD in 'tf 'tf D ιn ιn ιn ιn 'r ^ "tf ^ 'tf 'tf "tf "tf "tf 'tf 'tf 'r 'r 'tf "tf 'H 'tf "tf 'tf 'tf "tf ^ 'tf "tf "tf 'tf "tf ^ 'r "tf 'tf ro oo ro o oo ro ro r r r (^ (^ r ^ r-- ι co ro d O O ιn n o (Iι m (o t r~ cD CD <-θ cn cn o cM CM CM θ cn cn cn co co cD ιn cD ιn -^' θ θ d θ d CM d cn d o o cn co oo d CN d cN CM o 'tf ro d θ d d d o θ d ro d d CM o cn d oo r ro o o "tf "tf 'f 'tf 'tf ro ro ro ro e o r o ro ro rθ "tf 'tf 'r "tf "tf "tf M "tf "tf 'i' rθ 'tf 'tf 'tf "tf 'tf 'tf '^ "tf -t< "tf CO "tf

d d d d d CM C CM CM CM CM CN o ro ro ro oo oo o o o O 'tf ^ 'tf ^ 'tf in i i in Ln in in in co co io D D iD

^y^t ^* ^* ^3* ^* ^3* **•-* ^* ^* ^* ^* ^* ^J* 'ϊJ' ^* ^3* ^* ^* ^¹ ^* ^* ^* '•i' ^3* ^* ^* ^^ "^J* ''J' ^3* ^l* ^* *^t* "^J* ^T "'S' 3* *f ^* ^* ^J* 'si¹ ^J* ^P ^* ^* ^P ^P ^* ^* ^T* ^* ^* ^f ^3* ^* ^f ^* * * ^* ^* CM CN CN CM CN CM CN CN CM CN CN CN CM CN CM CN CN CM CN CN CN CN CM CN CN CN CM CN CM CN CN CN CM CM CM CN C^ ro ro ro oo oo ro ro oo ro oo ro oo oo oo oo ro ro co ro oo ro oo ro co n oo ro oo oo oo ro oo co n oo oo n oo n oo ro m co co co cocoa a a os aos a aosososos a u;ιa-(a-(a.a(-(o.s(ai;<(i;< rt;DaDDDDDD(.(iι-iiιθιnoι(iιaHiaaaaιiιiaHiιiHiιjaDD H M M M a a x xx x x " '- '- '--^x ^x- 'x-HaH H Ha Ha ω ωω ω fai ω ωωcococo c coc cocotf tf tf tf tf tf tf tf tf tf tf tf tf tf Ha H a a x a tH H tH fH EH Ei fH EH tH H H EH EH H EHEH EHtf tf tf tf tf Ha ι-i H H HaH H H tf tf tf tf tf tf tf tf > > > > > > >> > > > > > o d d CM d CM CM CM CM d CM d CM CM Ω Cxl fa] tf a CJ cj tf cjΩWΩωt a tf a tf acjΩΩ tf acjΩΩ tf acjcj tf a o cj tf z υ z o o z oυ o oυυυυυυooυoz oυυozooυυυυozυυυoooozυυυυo o z υoυυυozo

^ Λ Φ ^ oo o^ o d N tO 'l^, ιn Φ ^ co σι O ^ι f ^ ιn ^ oo ol o d c^ι tη ^ιn ^ ωm o H ι ιη 'f ιnΦ ^ ω ⁽^O H( (n'l• ι ^• co ol O H (^l (^ \^ o oo o oo d H d d d H d d t\i MN (\i( N N N N tη t tπιη (ηt ro ( tn ιη ^ ^ <j <» w ι» 'j 7 fl "i' in ιn ιn ιn ιn ιn ιn ιn ιn ιn Φ Φ io Φ i£i

CN CN CN CM CN CN CN CN CN CN CN CM CN CN CM CM CN CN CM CM CM CN CM CN CM CN CN CN CN CN CN CN CM CN CN CN CM CM CM CN

^ ^, "tf 'tf 'tf ^ 'r ^ ^ 'tf "tf "tf 'tf "tf ^ 'iⁱ 'tf ^ 'r ^ ^ ^ "tf "tf 'tf -iⁱ 'tf ^ ^ "tf 'tf 'tf 'r 'tf "tf 'tf 'r ^ 'tf 'j¹ ^ "tf '^ 'tf "tf "tf ^ ^ ^ "tf ^

00 rH MS 2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo H EH EH H H H EH H H EH H EH EH EH EH H EH EH EH EH EH EH EH EH EH H EH EH EH EH EH EH EH EH EH H EH EH EH EH EH EH EH EH EH EH EH EH H EH EH EH EH EH EH EH EH EH H EH H

© tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

r^ ^ d r-- u o cn v c ro co ιn co c c Lθ _> ro o «tf θ CN cn r~ CM CD in TO o c θ CD c^

^ o ^ Φ t tn ιn ^ ω Φ Φ foo ^ ^ ι m ^ ιn ιn σl ιn H H H σι ^ o ι H 03 « Φ ι M Φ 'ϊ ιn (Jl tn tη Φ co H ^ Φ N ^ n co m o (3 0 !!l o^ « Φ N o ιn oo cn cn ro cM ro oo ιn o ιn ^ co oo ιn cD o cM r~ ro o cΛ θ ιn r~ o oo o cD oo ro o co ιn cN θ "tf d CM "tf CM "tf d σ cM r~ ιτi "tf CD

^ f t m (η ιn ιn <^| "l' ιn Φ ^ ^ (D ^• ιη N ^l riO d oo o o o tB ^ co r" Φ Φ ^ Φ ^ ^ ∞ Φ ^o ιn n (η H O d (Λ Φ ^ ^ ^ ^• tD ιn Φ ιn ιn

CN CM CM CM CM CN CN CN CN CM CM CM CN CN CM CN CM CM CM CM CM CM CN CM CM CM CM CM d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d oo co o o cM r- o o ro n oo cM CD oo cM cn r-- cn o cn o cn d d "tf cn co ro ιn "tf CD ro co cn cn r~ ^ cN C» oo r^ cN in ιn cN ∞ r-- τι c cN θ 'r cM τι cD d r~ θ d ι oo r~ oo ∞ c d oo o c^ ιn 'tf CN r-- ιn o cD o σo cn r~ ιn d ^ ιn cM i r^ r~ co cD C^

« 00 O H O O lJl ^ ( σι Φ ^ Φ Φ Φ ^ H (n H ιn (^ Φ O (η H ^ o ιη ^ '* ^,- ^ ^ Φ ^- ω H * ι^,l m ^ι o O N r• tι^ t0 O Φ 'l' ιJl Φ M 03 ■* rι Φ

CM CM -tf d w cn r-- r~ oo cD r_^ cD r~ oo σι σι θ d cn cn co r-- r~ ιn cD r~ co oo oo cn cn o oo oo oo co cτι cn cn cn o o o d CM O d CM d CO rO CM T OO m CO CD

"tf "tf 'tf 'tf ro ro ro ro ro ro ro oo oo t^ oo ro -^ 'tf ro ro oo oo ro co oo oo ro ro oo oo oO 'r ro ro ro oo oo oo ro oO 'tf 'tf 'tf 'tf "tf "tf ^f ^3 ^J* ^1* ^ * ^3* j *^ji ^ * *sj' j* ιn ro r~ cM in ιn ^ r~ o co r_^ co d "tf iθ "tf oo ι co ιn cD 'r cM r^ o o d r--- cn ι D (~ o o ^ co fθ o ^ «tf crι ^ ιIl c^ι ιn ^ ιn H (η ^ 'τ ^ tn ω( Ol o ^ (Jι H ^ N O N ιn H ιI) H ιn o n c^ι ι ^ ιn '* ιn <^ '» 03 ιn o n Φ ιn co o o oo oo oo t n Φ σ^ ^ o to _ in o ^ r^ in oo cM Co o cM o r~ cN cri 'w cN O 'tf in oo cM O CM co i oo cM t^ o o in r^ cM ro in cM d cn ro r~ o c r~ ^ o CM ro d CN d ro oo oo o Lθ m m r- oo cN " 'tf m co r- m 'tf CD CD ^ι r~ r-- 0000 r-- CD in in 'tf "tf <rι O O CM CM CM d d CM CM CM d O CM ^,«¹ CM - ' "tf CM CM d d Cn l I l I

mmmmφij>mooooooooooodHHdHCN^,ciNMN( Nnnι nιηιηtom(if 'r>f"rHrv'9'»"j^^«ιnιnιfiιnιrιιnιnιoιoΦ _"tf _"tf "tf -^_"tf _^r_"tfinιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnιnι^ oo co ro oo ro co ro c oo ro ro oo ro ro oo ro n oo ro ro oo oo oo oo c^ oo oo ro ro ro ro oo oo ro r^ D D D D D D D O CJ O O O tf tf tf tf tf O O O O O O O CO CO CO C W C C CO C CO CJ O O CJ U O O O O O O O O O Cx] |_] [χl ^^ ^ ^ ^ Λ c &eύ ύ ozcύ iύ&ozoici rHri rΑrH'r &cύiύoicύ cύeC H ocj o oo tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf aaa a a a a a a a a aa aa aa tf tf tf tf tf tf tf tf tf tf tf aaaa a aM H H d CM d CM CM d d CM d CM a cj Ω cχi ω tf acjΩωcoaa tf a Ω tf a cj tf acjΩΩwω tf aoΩωcoaa Ω tf a o tf a υ υ o o o o o zoυυυzυzz υozυoυozυooυo ozoυoυzozυozooυυzυzz υozoυoυυo u o

00

2222222222222222222222222222222222222222222222222222222222222 0000000000000000000000000000000000000000000000000000000000000

H EH EH EH H H EH EH H H EH H EH EH H EH tH EH EH EH H EH H EH EH EH EH EH EH EH EH EH H EH EH EH EH EH EH EH EH H EH EH H eH EH EH EH EH H H EH EH EH EH EH EH EH EH EH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

o ol O N O N (loo Φ CD H tη d d d d d d d d d CN CM oooooooooooo oooooooooooo o d tη (η ^N ^ ^ ^ "f co l (I) σι H o ιn H ^n o "» "l^ι N "^ o t σι ra d n m o m Λ ι H (!^ H O o ιn ^ ιn ω ^ Φ H tnΦ ^ (^ι to n o ln ^ ιn

'tf σ^ oθ "tf θ r- CM C CD o c "tf θθ "tf d D d 'tf 'tf in D oo oo t cD o -tf r--- ιn '^ D r^ o ιn cM c r^ ro ι r cM θ o n oo cM

Φ (η ιn Hf ιn ^ O ll' ιn σl on ω ^ H m oo Φ ^ tι v o M <) Φ H (Λ ∞ ιn σιω tnιn fll H ^ ^ ^ Φ ^ o ^ ιη n t^l o ι ι t<) (l H ^ σl rη N H Φ

'f in i in -T 'f tn o m ω m Λ O tηn 'j n H H H HW ri o mo m oi c oi r- Φ in 'ϊ 'tf ro r- r- r- t- dddddddd d dddddddddddddd d

O O CD 00 d d

-r oo cn co d LO r- 00 LO CD 00 d r~ ιn ιn r~ oo oo oo σ^ oo oD oo o θ d c^ "tf in "tf "tf 'tf r ro o o (^ 'tf in 'tf D CD r^ ιn ιn ιn r~ r-- oθ "tf r 'tf c D ι^ 'tf 'tf "tf r 'tf '" '^ ^,^ 'tf 'r "tf i ιn L ιn ιn ι ι ιn ιn ιn ιn Lθ Ln Ln Ln ι Ln ιn Ln ιn ιn ιn ιn ι ιn ιn Ln ι Lθ in Ln ι^ m m m uo in co m in in co cD CD co

■ o o ι<) H Φ r- t in c- d h o Φ (i ( d N tn ιn ιn (') o o (io o H d θ3 p- M Φ "i' Φ "i^| !rι ^ tD θ H φ ιn ^ <n o (o r- N N ^ ιi ι H θ H (η ι ιn N ( o ^ H Λ ^ ι o Φ ιn d ιn d ιn (N ^ ^ n Φ (^ Φ d ^ (η ol o ιn oo (» "^ co (Jι o^ ιn ^ ^!l ιn <J> N oo ι H π O Ol ^ t^,1 ιn ι7ι d ι oo ιn H ι ι t^Φ N "f 'l^, ι Φ (^) ^ o o l H ^ ^ι o ιn o ^ o co <J H cl l o lnt^rιtn m 'f Φ ^ "l' Ol ω ^ H o rι ιn "ϊ O (^ι ι<^oo ffι o -^ cn oo r- d d C co ^■w m _> m c d CN d d o cn co cn cN oo d d o cN d ro ')' in "tf CD m - "tf in r- CO OO O OO O O OO OO OO OO r- O d O d d d d O d O O d d d d d CM CM d d d d d CM CN CM CM CM CM CM CM CM CN CN CM

Φ ^ ^ ^ ^ ^ ^ ro (D m co α) co co o3 Co m ^ σι cn crι o o o O d H H d d « N ( <l ^l N N ^^ (^,l ^ (^,) '^ 'I <ι^, 'l' '» ^ fl' ^ ul ιn in in in in in in in in -o in -o in in in -o in in in in in Lo in in -n i^

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM t^ CM CN CM CN CM CM CM CN CM CM CM CM C^ ro ro ro ro oo oo oo ro ro ro ro ro oo ro co oo ro n ro n oo ro ro ro ro oo oo ro n oo ro n co oo oo oo oo ro oo oo oo n oo oo

Cd fal tl fal Cd D D O O D D D D Z Z Z Z Z Z Z Z Z tf tf tf tf tf X X X X D D O D D t-- D D O O O O O O O I tf tf Z Z Z Z Z Z Z Z CO CO

HiaaHiJwwwwwωωwaaaaHiaaaiaaaJaaa^i iawωωuu- cxiωaaaaaaa i Ha Ha coco co cococo eocox x HMMHMHaH H iHH iHH Haoo oo jocjcjtf tf tf tf tf cjcjc cjH HaH H Haι-a πaπaaaaaaaa tf tf tf tf tf tf tf tf tf tf πa πa

CM d d d CM d CM d CM d CM

CJ CJ Ω tf a O Ω Ω tf a Ω Cxl fa] tfa tf tf a J Ω Ω Ω tf a cj tf a tf a J Ω Ω ooooozooυυυυozoυϋoozooz o o o o z o o ozooooooo z o o o o o o z o o o o o o o o z o o z

Φ ι Φ

CM oo

00 rH

2222222222 2222222222222222222222222222 22222222222222222222222 0000000000 O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O EH EH H EH EH EH EH H EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH H EH EH EH EH fH EH H H B EH H H H h EH H H H H H tH h ti H H EH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

ω tn o o ftπ cN co α_{3 d} o o σ^ θ tn m Φ o t\i (θ 'f H θ i^,) H i») cι cιj ^ M θ3 in ιn o d "f "f d d θ !Λ θ ( inrn ιn d "» d i r- d i ι ιn r- ιn o r" d fli d in 5r 'j o θ co d Φ in d l ι ri v (D ιn Λ o ιη d n H m l^| Φ o n N n (B ^η ιn <J n n l o ^ ^ ιn HO ^ (^,^ r^ ffι H '^ι^ι o tη tn o ΦCN O 'f l»l α) ^^■ H ^^• r- o co r- r_^ d d e in o o o co c o o cM o d 'i' r_^ d r_^ r oo cD cD o o co c d o oo oo ro c^ o cM cM CM r σ^ oo o co d oo j ∞ cM C co ι D <^ cM 'tf in D in cD CD r~ CD r~ cD D in r^ r~ ∞ ^ o oo co oo oo co r~ cD D co c r^ ∞ c» oo ∞ ∞ ∞

ID CO CO CD CO CO CD CD CD VD CO CO CO CD lO CO CD CD CD CD CD CD CD r^ CD CO lO CD CD CD CD CO CD CD CD CD CD CD CD CD CD CD CD CD CD C^

^ ^ ^ o d C ln ln Φ ιn "^ "f n co ιn w ^ Φ O o O "ι^, N ^ n o o ι o ιn ω ιn n oo ^ ^ ^ w ol N 03 ro 'ι^, oo ⁾ ιn ^ H ^ oo oD ⁽η (o ι "l' ^ ιn o3 oo o cn ro cM d d θ CM oo oo σ^ cN CM co d r~ cM in r~ ιn cn co r~ co o co d cn ~ cD oo oo 'tf r~ cD co cD ιn oo rθ 'tf θ cyι u^ ω ^ H "f ^ ιn ω o ^ ω Φ ^ Φ ^ (0 'l^| H '( < H ^ "l' ιrι n ^ (Jι ^^ ^ ιn » w m o H ro ra ^ '^ (n ιn N ιn N o w ^ o σi H 'I Φ O ^ ^ 'J 'f Φ

C t N M tθ (θ ^ ιn « ι ιn 'f Φ ι cooo ^ ι m o o d N N n ^ ^ Φ "i^, 'f in ui (^,) i») ( H θ θ H θ θ θH (i H a) o5 co r- r- iJ> Φ in <» cM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM ro ro ro ro ro ro ro n oo oo oo ro oo oo co n ro oo oo n o^

ιn ιn Lθ in ιn ιn ιn _> ιo -> ιo -> -> ιθ ι~ r~ r~ r~ ι--'- r-- r^ ro oo oo n oo oo ro n oo m oo oo oo oo oo co n oo n oo oo oo oo oo oo n oo oo ro oo ro ro ro m oo n oo oo oo m m ro ro ro o oo oo r^ coco coωωaaaaosaaiHHaiHHaH HaH tf tf tf tf tf DDDDDDDDxxxxaosaaaazzzzzzzzH HaH H HaH H DD xxxxxxxasa aaaatf tf tf tf fttf tf π iHH H iafaiωωωωωωwμiHaiHHaωωωωωwaMwcoωcocoOTtf tf tf tf tf tf tf .-iH j H πi iJ ia iJ ^jHEHEHEHEHEHEH>>>>>>>tf tf tf tf tf H HaH H HaH HaH joc owcoac oc tf tf tf tf tf tf tf tf >>>>>>>cjcj d CM d CN d CM d CM d CM acjΩfaico tf acjcj tf acjo tf a tf a O Ω Ω tf tf ao tf oΩΩ tf acjcj υυoυzoozooooυozυoooυozoυυo O O ozooozooooozυυυozoozυυooo tf o z υ

^ tB m o d N ιη ^■^^ ιn Φ ^ oo m o H ⁽ι tη Hf ι Φ ^ ⁽X⁾ Λ O H ^ι n ^ ι Φ ^ „ Λ O ri ι n 'l^ι Λ Φ ^ flO Λ O w m ^ ιn ^ co <Jl O H N n ^ ln ^ t003 ∞ 01 1 ⁽Λ 1 t7l ⁽Λ trι ⁽I10i m o O O O O O O O O O d d d d d H d d d H M (\I N N (V| N N N N N m M n M t m r m (θ m * '|ⁱ 'f "l^l "r ^ ^ ^ o ro co c o r o oo o o o co c "tf ^ 'f 'tf 'tf 'tf "tf "tf 'r "tf 'tf '^ ^r "tf 'tf "tf 'y 'r 'r "tf 'tf 'tf ^ ^ ^ ^ "tf ^ "tf 'tf "tf 'tf "^

^tf ^* ^* ^l¹ ^* ^F ^J* ^* ^tf ^* ^* ^* ^* ^* 'tf ^* ^ⁱ ^* ^ ^ⁱ ^ⁱ ^ ^ ^ⁱ ^ⁱ ^ⁱ ^ⁱ ^ⁱ ^ ^* ^ ^ⁱ "tf ^* "tf ^* ^* ^* ^* ^* ^* ^* ^* ^ ^* ^J¹ ^ ^T ^* ^* ^* ^* ^* ^* ^* ^* ^* "tf "^P "d* "ζjl

00 rH

2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

EH EH EH EH H EH EH EH EH EH EH EH EH EH H EH EH H EH EH EH EH EH H EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH H EH H EH H EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

O

Table 2

ATOM 4448 CB GLU 3274 23.979 62.074 17.690 ,00 23.38

ATOM 4449 CG GLU 3274 24.913 62.655 18.749 ,00 27.48

ATOM 4450 CD GLU 3274 24.164 63.399 19.858 ,00 31.71

ATOM 4451 OEl GLU 3274 23.681 64.538 19.628 .00 32.69

ATOM 4452 OE2 GLU 3274 24.048 62.833 20.965 .00 31.25

ATOM 4453 C GLU 3274 23.649 60.737 15.610 .00 21.95

ATOM 4454 O GLU 3274 22.935 61.400 14.861 .00 21.49

ATOM 4455 N PHE 3275 23.597 59.418 15.672 .00 19.24

ATOM 4456 CA PHE 3275 22.626 58.674 14.916 .00 19.23

ATOM 4457 CB PHE 3275 23.287 57.514 14.191 .00 19.10

ATOM 4458 CG PHE 3275 24.127 57.924 13.024 .00 19.09

ATOM 4459 CDl PHE 3275 23.549 58.509 11.903 .00 16.19

ATOM 4460 CD2 PHE 3275 25.502 57.691 13.032 .00 18.92

ATOM 4461 CE1 PHE 3275 24.327 58.856 10.798 .00 19.77

ATOM 4462 CE2 PHE 3275 26.296 58.033 11.930 .00 19.55

ATOM 4463 CZ PHE 3275 25.709 58.617 10.809 .00 19.45

ATOM 4464 C PHE 3275 21.674 58.146 15.976 .00 21.86

ATOM 4465 0 PHE 3275 22.112 57.809 17.079 1.00 21.13

ATOM 4466 N MET 3276 20.381 58.089 15.651 1.00 22.58

ATOM 4467 CA MET 3276 19.374 57.594 16.581 00 20.39

ATOM 4468 CB MET 3276 18.189 58.559 16.669 00 24.62

ATOM 4469 CG MET 3276 18.569 60.006 16.901 00 28.34

ATOM 4470 SD MET 3276 17.107 61.034 17.050 00 35.45

ATOM 4471 CE MET 3276 16.966 61.152 18.854 00 30.79

ATOM 4472 C MET 3276 18.875 56.255 16.096 1.00 17.79

ATOM 4473 O MET 3276 19.039 55.897 14.940 .00 18.35

ATOM 4474 N CYS 3277 18.248 55.520 16.992 ,00 17.70

ATOM 4475 CA CYS 3277 17.710 54.222 16.662 ,00 20.83

ATOM 4476 C CYS 3277 16.625 53.942 17.694 ,00 20.81

ATOM 4477 O CYS 3277 16.870 54.046 18.888 00 21.06

ATOM 4478 CB CYS 3277 18.814 53.177 16.750 ,00 22.91

ATOM 4479 SG CYS 3277 18.391 51.532 16.092 ,00 30.91

ATOM 4480 N LYS 3278 15.424 53.617 17.232 ,00 21.63

ATOM 4481 CA LYS 3278 14.317 53.330 18.133 ,00 22.79

ATOM 4482 CB LYS 3278 13.116 54.204 17.774 ,00 22.66

ATOM 4483 CG LYS 3278 12.549 55.036 18.920 .00 25.77

ATOM 4484 CD LYS 3278 11.525 54.270 19.754 ,00 27.26

ATOM 4485 CE LYS 3278 10.787 55.171 20.761 ,00 32.36

ATOM 4486 NZ LYS 3278 9.998 56.303 20.152 1.00 36.39

ATOM 4487 C LYS 3278 13.964 51.854 17.991 1.00 22.92

ATOM 4488 O LYS 3278 13.645 51.388 16.903 1.00 26.50

ATOM 4489 N VAL 3279 14.010 51.128 19.101 1.00 19.71

ATOM 4490 CA VAL 3279 13.740 49.699 19.101 1.00 17.12

ATOM 4491 CB VAL 3279 15.001 48.917 19.619 1.00 17.18

ATOM 4492 CGI VAL 3279 14.748 47.431 19.611 00 16.48

ATOM 4493 CG2 VAL 3279 16.218 49.251 18.782 00 14.76

ATOM 4494 C VAL 3279 12.563 49.360 20.009 00 18.51

ATOM 4495 O VAL 3279 12.359 50.014 21.036 00 17.83

ATOM 4496 N TYR 3280 11.772 48.365 19.611 00 18.37

ATOM 4497 CA TYR 3280 10.663 47.877 20.434 00 19.65

ATOM 4498 CB TYR 3280 9.283 48.153 19.848 00 21.02

ATOM 4499 CG TYR 3280 8.217 47.325 20.584 00 26.66

ATOM 4500 CDl TYR 3280 618 47.794 21.765 00 26.80

ATOM 4501 CE1 TYR 3280 736 46.989 22.504 1.00 24.94

ATOM 4502 CD2 TYR 3280 890 46.025 20.160 1.00 24.05

ATOM 4503 CE2 TYR 3280 012 45.219 20.896 1.00 24.17

ATOM 4504 CZ TYR 3280 442 45.706 22.064 1.00 25.11

ATOM 4505 OH TYR 3280 602 44.905 22.807 1.00 26.64

ATOM 4506 C TYR 3280 10.859 46.370 20.461 1.00 20.50

ATOM 4507 O TYR 3280 11.101 45.749 19.423 1.00 20.46

ATOM 4508 N SER 3281 10.724 45.771 21.632 1.00 18.62 Table 2

ATOM 4509 CA SER 3281 10. .951 44. ,352 21. .722 1. ,00 18. .26

ATOM 4510 CB SER 3281 12. .446 44. ,103 21. ,521 1. ,00 13. .72

ATOM 4511 OG SER 3281 12. .762 42. .733 21. .584 1. ,00 23. ,33

ATOM 4512 C SER 3281 10. .489 43. ,821 23. .067 1. ,00 20. ,13

ATOM 4513 O SER 3281 11, .004 44. ,249 24. .092 1. .00 23. ,43

ATOM 4514 N ASP 3282 9, .506 42. ,915 23. ,071 1. .00 21. .92

ATOM 4515 CA ASP 3282 9, .023 42. ,327 24. ,319 1. .00 18. .13

ATOM 4516 CB ASP 3282 7, .911 41. ,313 24. ,046 1. .00 17. .35

ATOM 4517 CG ASP 3282 7, .463 40. .592 25. .297 1. .00 23. .20

ATOM 4518 OD1 ASP 3282 6, .423 39. ,898 25. .266 1. .00 21. .51

ATOM 4519 OD2 ASP 3282 8, .160 40. .709 26. .324 1. .00 29. .34

ATOM 4520 C ASP 3282 10, .238 41. ,675 24. .993 1, .00 17, .69

ATOM 4521 O ASP 3282 10, .647 42. ,102 26, .072 1. ,00 18, .82

ATOM 4522 N PRO 3283 10, .837 40. .640 24. .379 1. ,00 16, .79

ATOM 4523 CD PRO 3283 10. .440 39. .777 23. .257 1. ,00 16. .75

ATOM 4524 CA PRO 3283 12. .003 40. ,079 25. .072 1. ,00 18. .89

ATOM 4525 CB PRO 3283 12. .267 38. ,779 24. .315 1. .00 19. .64

ATOM 4526 CG PRO 3283 11. .723 39. ,043 22. .959 1. .00 17. .42

ATOM 4527 C PRO 3283 13. .165 41. ,070 24. ,982 1. .00 18. .93

ATOM 4528 O PRO 3283 13. .200 41. ,882 24. ,064 1, .00 19. .18

ATOM 4529 N GLN 3284 14. .100 41. .017 25. ,927 1. .00 20. .79

ATOM 4530 CA GLN 3284 15, .228 41. .954 25. .923 1. .00 23. .12

ATOM 4531 CB GLN 3284 16. .190 41. .670 27. .079 1. .00 26. .64

ATOM 4532 CG GLN 3284 15. .686 42. .185 28. .403 1. .00 31. .18

ATOM 4533 CD GLN ■ 3284 15. .444 43. .677 28. .369 1. .00 33. .51

ATOM 4534 OEl GLN 3284 14. .530 44. .187 29, .025 1. .00 37. .06

ATOM 4535 NE2 GLN 3284 16. .270 44. .392 27, ,611 1. .00 30. .56

ATOM 4536 C GLN 3284 16. .024 41. .991 24. .632 1. .00 22. .12

ATOM 4537 O GLN 3284 16. .584 40. .984 24. .198 1. .00 22. .15

ATOM 4538 N PRO 3285 16. .088 43. .170 24, .000 1. .00 21. .03

ATOM 4539 CD PRO 3285 15, .338 44. ,399 24, .314 1. .00 18, .24

ATOM 4540 CA PRO 3285 16. .831 43. .327 22. .748 1. .00 20. .96

ATOM 4541 CB PRO 3285 16. .141 44. .520 22. .100 1. .00 16. .42

ATOM 4542 CG PRO 3285 15. .890 45. .387 23. .289 1. .00 17. .30

ATOM 4543 C PRO 3285 18. .308 43. .614 23. .016 1. .00 19. .61

ATOM 4544 O PRO 3285 18. .652 44. .229 24. .019 1, .00 17. .18

ATOM 4545 N HIS 3286 19. .172 43. .159 22. .122 1, .00 18. .93

ATOM 4546 CA HIS 3286 20. .590 43. .421 22. .256 1. .00 21. .50

ATOM 4547 CB HIS 3286 21, .386 42. .122 22, .155 1, .00 24. .23

ATOM 4548 CG HIS 3286 22. .858 42, .309 22, .322 1, .00 31, .35

ATOM 4549 CD2 HIS 3286 23. .614 42. .468 23, .436 1 .00 35, .30

ATOM 4550 ND1 HIS 3286 23. .725 42. .413 21, .255 1, .00 33. .71

ATOM 4551 CE1 HIS 3286 24. .949 42. .629 21, .702 1, .00 35. .42

ATOM 4552 NE2 HIS 3286 24. .909 42. .667 23, .023 1 .00 36. .55

ATOM 4553 C HIS 3286 20. .909 44. .351 21, .094 1 .00 20. .80

ATOM 4554 O HIS 3286 20. .759 43. .969 19, .941 1 .00 23, .48

ATOM 4555 N ILE 3287 21. .334 45, .573 21, .391 1 .00 20, .39

ATOM 4556 CA ILE 3287 21. .621 46, .542 20, .339 1 .00 20, .95

ATOM 4557 CB ILE 3287 20. .963 47, .928 20, .640 1 .00 20, .11

ATOM 4558 CG2 ILE 3287 21. .540 48. .991 19, .725 1 .00 18, .21

ATOM 4559 CGI ILE 3287 19. ,453 47, .874 20. .409 1 .00 17, .87

ATOM 4560 CDl ILE 3287 18, .684 47. .133 21, .453 1 .00 19, .51

ATOM 4561 C ILE 3287 23. .098 46, .781 20, .079 1 .00 22, .79

ATOM 4562 O ILE 3287 23. ,882 46. .958 21 .004 1 .00 26, .54

ATOM 4563 N GLN 3288 23. ,465 46. .802 18, .803 1 .00 24, .49

ATOM 4564 CA GLN 3288 24. ,847 47. .044 18 .394 1 .00 26, .54

ATOM 4565 CB GLN 3288 25. ,519 45. .772 17 .891 1 .00 27, .11

ATOM 4566 CG GLN 3288 25, .897 44. .755 18 .923 1 .00 29, .11

ATOM 4567 CD GLN 3288 26. .700 43. .633 18, .300 1 .00 32, .97

ATOM 4568 OEl GLN 3288 26. .985 42. ,623 18. .942 1, .00 36. .15

ATOM 4569 NE2 GLN 3288 27. ,077 43. .809 17. .035 1, .00 34. .32 Table 2

ATOM 4570 C GLN 3288 24.871 48.020 17.240 00 27.48

ATOM 4571 O GLN 3288 23.938 48.058 16.432 00 28.66

ATOM 4572 N TRP 3289 25.933 48.811 17.157 00 26.47

ATOM 4573 CA TRP 3289 26.067 49.736 16.045 00 26.74

ATOM 4574 CB TRP 3289 26.374 51.152 16.533 00 23.41

ATOM 4575 CG TRP 3289 25.166 51.857 17.065 00 23.14

ATOM 4576 CD2 TRP 3289 24.250 52.667 16.319 00 24.29

ATOM 4577 CE2 TRP 3289 23.249 53.110 17.221 00 24.25

ATOM 4578 CE3 TRP 3289 24.176 53.068 14.977 1.00 21.24

ATOM 4579 CDl TRP 3289 24.696 51.836 18.350 00 23.53

ATOM 4580 NE1 TRP 3289 23.546 52.587 18.453 00 21.95

ATOM 4581 CZ2 TRP 3289 22.191 53.930 16.821 00 21.61

ATOM 4582 CZ3 TRP 3289 23.128 53.882 14.585 00 20.89

ATOM 4583 CH2 TRP 3289 22.148 54.303 15.505 00 21.46

ATOM 4584 C TRP 3289 27.209 49.187 15.212 00 27.47

ATOM 4585 O TRP 3289 28.209 48.729 15.770 00 26.21

ATOM 4586 N LEU 3290 27.062 49.206 13.890 00 27.19

ATOM 4587 CA LEU 3290 28.112 48.670 13.030 00 30.23

ATOM 4588 CB LEU 3290 27.654 47.363 12.364 00 30.65

ATOM 4589 CG LEU 3290 26.744 46.363 13.088 00 32.74

ATOM 4590 CDl LEU 3290 26.405 45.229 12.126 00 32.45

ATOM 4591 CD2 LEU 3290 27.415 45.814 14.331 00 31.09

ATOM 4592 C LEU 3290 28.540 49.627 11.925 00 31.63

ATOM 4593 O LEU 3290 27.706 50.259 11.281 00 32.46

ATOM 4594 N LYS 3291 29.847 49.725 11.706 00 31.42

ATOM 4595 CA LYS 3291 30.367 50.556 10.636 00 30.67

ATOM 4596 CB LYS 3291 31.649 51.270 11.086 00 32.02

ATOM 4597 CG LYS 3291 32.367 52.067 9.979 00 34.48

ATOM 4598 CD LYS 3291 31.482 53.169 9.410 00 36.64

ATOM 4599 CE LYS 3291 32.240 54.108 8.483 00 37.18

ATOM 4600 NZ LYS 3291 32.575 53.496 7.171 00 40.53

ATOM 4601 C LYS 3291 30.677 49.592 9.483 00 31.41

ATOM 4602 O LYS 3291 31.101 48.457 9.703 00 32.63

ATOM 4603 N HIS 3292 30.450 50.025 8.257 00 29.58

ATOM 4604 CA HIS 3292 30.744 49.181 7.123 00 30.27

ATOM 4605 CB HIS 3292 29.750 49.477 6. 012 00 32.12

ATOM 4606 CG HIS 3292 28.356 49.047 6. 340 00 35.10

ATOM 4607 CD2 HIS 3292 27.449 49.557 7. 208 00 37.52

ATOM 4608 ND1 HIS 3292 27.782 47.917 5. 807 00 36.31

ATOM 4609 CE1 HIS 3292 26.580 47.746 6. 332 00 37.82

ATOM 4610 NE2 HIS 3292 26.356 48.728 7. 185 00 36.14

ATOM 4611 C HIS 3292 32.167 49.447 6. 674 00 33.55

ATOM 4612 O HIS 3292 32.593 50.595 6. 598 00 37.07

ATOM 4613 N ILE 3293 32.923 48.393 6. 403 00 36.32

ATOM 4614 CA ILE 3293 34.305 48.570 5. 961 00 38.28

ATOM 4615 CB ILE 3293 35.306 47.935 6. 941 00 38.79

ATOM 4616 CG2 ILE 3293 36.727 48.397 6. 594 00 39.12

ATOM 4617 CGI ILE 3293 34.959 48.331 8.374 00 40.05

ATOM 4618 CDl ILE 3293 35.815 47.629 9.413 00 42.09

ATOM 4619 C ILE 3293 34.524 47.942 592 00 36.87

ATOM 4620 O ILE 3293 34.286 46.754 413 1.00 35.64

ATOM 4621 N PRO 3306 28.867 41.727 498 00 50.53

ATOM 4622 CD PRO 3306 27.398 41.849 543 00 49.75

ATOM 4623 CA PRO 3306 29.512 43.010 3.811 00 49.98

ATOM 4624 CB PRO 3306 28.333 43.986 .832 00 48.87

ATOM 4625 CG PRO 3306 27.204 43.134 ,329 00 48.75

ATOM 4626. C PRO 3306 30.270 42.985 ,142 00 49.99

ATOM 4627 O PRO 3306 29.706 42.596 ,172 00 50.18

ATOM 4628 N TYR 3307 31.541 43.393 ,126 00 49.25

ATOM 4629 CA TYR 3307 32.328 43.399 363 00 49.05

ATOM 4630 CB TYR 3307 33.815 43.615 087 00 53.62

ooooooo ooooooo

^ ιn o H w N ^ o ^ ^ (ι ιn "f lJι w ^ (!l ιn o '» H Λ n ^ m tΛ (η^ 'p coO 'J^, oD (Iι ^ o ^- O ri ι ιn w w m Φ c^• o ^ⁱ σι o ιn ^ H m H ^ o ^ !l o oa ^ H ^ ^ ιn ^ H t!ι ^ ^ ιn m ^ H m o n ^ l ^ Φ l l O H Φ (B "f ^ ^ H Φ d Φ Φ '^ω H ra Φ 'f ι (ι^ H C^ι (D U1 o m o^ ^ ol m ^ N ∞ ιn ln o ω l Ol ιη ιn (ι ^ d d N Φ ^ Φ ^ (a m ιn ^ Φ ^ (η ιn H ι o ^ o tη ιn oo o oo Φ Φ tB N n oΦ ιnΦ <J\ ^ ol

"tf c 'tf (^ cN d ι-- ιo oo cn o ∞ o o o d CM CM ro o cM ^r o 'q' in cD r-- cD ιn cD CD cD r-- <_i ιn "tf m oo oo cn o o d d ro cN θ cn d CN CN d cN rθ "tf oo τ "tf in d d d d CM CM CN CM CM CM CM d C CN CN CN CM CN CM CM CN CM CN

0 '^ o tη r m ^ o ιn H O Ol o ω c^ι ^ι ιn '^ H O 'i^ W N Otn Φ "1^| tD ι ιn H H ⁽Jl ιn ιn oo ^• <f t»l ιn ^ ι o^ ^ Φ ιn tO ιn (Jl d o3 ιn (Il no m ιn m t^ ιn n tη o H c^l C ^ σι <n H H ^ ^ ιn ιn ^ N Ol H ιn '» o^ σι ^ (J) ^ ιn "» d tι ^ Λ H n ιn to ^ m o ^ H ^ N v σι ^^ H (]l N ι ω 'ι^ι ^ ω m ιn oo ιn ιn f^ (n o ιτι ^ n ^ ι t-- m N ιn ω 'r H W ( ιn (^ ^ o σl ^ _ ^ ⁽ H (^ Φ ^ O H m m H ω H σι N O H co ιo ι tη o ^ w o oo

(^l (O N H O o ^ ιn ^ ι ι ^ n ιn 'f Φ ∞ fll ll o ^ ω Φ Φ ιn ιn ^ p^ ^ ^ OJ lJl d ^ι d o o ol Λ H H n toιn oo co oo Φ ιn ιn '* ^ ^- ^ ^ Φ "tf "tf "tf 'T 'tf 'r 'ji 'r "tf ^ι^ 'tf 'tf ^ ^ "tf "tf ^ 'r '^ 'i^, 'r '^ ιn 'tf 'tf "tf 'tf 'tf "tf 'i 'tf "tf 'tf "tf "tf i ιn ιn L ιn ιn ^ ^ ιn ιn ιn ^

(n ^ ooσι Φ Φ O H (o ^ o oΦ "^' ri ^- t Φ l N ιn Φ ιn ^ O ⁽J ^ ^ Φ t ι^,l Φ Φ ⁽η ιη 'I P^ J (η H H ^ d (η ⁽Il ⁽^ι ^ !^ H o no H N O ^•

CM cn 'tf r-- ro oo 'r "tf r~ "tf θ CN r~ o o cM r^ ro ^ d "tf r-- ^ oo ι o co cN ι^ ι cD σ3 d CN Co vD ( ) σ^ σι r cN 'tf ^ oθ d CD cn ro cM VD ∞ ro cn ιn d d o ιn oo «tf CN CM CM C^ ιn r~ oo r~ d θ co co o cD oo o cn ^ oo cM CD r-- σι oo cD d (M CM "tf

^ N^ 'l|^ι ^ ιn Λ ιn d d d d O ffι o N n N n ^ ιn ιn Φ ιn ^^ H N d d O d (Jι tη o d O d o ι o d (Il m oa a) ^• co ^ ol ^• a! <Λ ^• Φ ^ ιn ^^ p^,) ιn r ro oo oo oo ro oo ro ro ro ro ro co cM ro oo oo oo ro oo ro oo oo oo oo ro oo ro t^ ro oo cM eo ro ro oo n ro n oo oo ro cN CM ^ C

r~r~r^r^r---r-r^r~r-~cDraoooooooorocnooOTcncncncncncnooooooooddd

O O O O O O O O O O O O O O O O O O O O O O O O O d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d ooroooroooroooromoororooooororoc^rororoooooooroeororororoooooroooM oororoooooooooooooncorooororo rorororooooooorororororororomroooroooooooroooror^ i- Di i. a: a; ts i- i. Hi ii a a X X X X X X X X X tf tf tf aaaazzzzzzzzzubii- ω ω xi ω ω D Ω D D D D D D co c co a a co c ω a a a a a os a tf tf tf tf

Ha Ha H Ha Hi a ω ω ω w ω ω ω x x x x x x x a a H i- H H

EH EH EH EH EH EH EH EH EH > > > o; rtaaaajaajajaaM Hi

> > > > O CJ O CJ CJ CJ CJ CJ CJ M M M H H HH HH H H a a a ni a a a a Hi j a Hi a ia ij j ia EH H EH EH H tH EH rt; <; (i; i!t; d d CM CM d CN CM CM d CM O Ω fa] Ω fa] CO K tf a cj u tf a cjΩ Cxifai tf a oc Ω tf a o Ω Ω tf acjΩfaico tf aocj tf a O O O O O O O O z υ o o o o o z ooυυozoozoυυυυoo υ υ υ υ υ o o ooυoυzoozooooυozooυ in co r-- oo cn o d oo oo oD oo oo ol σι VD CD CD CD CD CO CO

00

MS

22222222222222 2 222 22 222 22222222222222222222222 222 22222222222 O O O O O O O O O O O O O O O O O O O O O O O OO OOOOOOOOOOO O O O OOO O OOO OOOOOO OOOOOO OOO β EH EH EH EH EH EH EH H EH EH EH H EH EH EH EH EH EH EH EH EH EH EH H EH EH H EH EH EH EH EH EH EH H EH H EH EH EH EH EH EH H EH EH EH EH EH EH EH H EH EH EH EH EH EH EH EH EH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

O

π

O H '_l ^, H Λ ιn oo cD io _ ιn co cN d CD tn o ιn ^^l H ι n

CM CN CN CN CM CM r- o ro o d in 'tf θ oo cM cn ιn co -r cn r "tf d cn cM d in cN co r--- o oo oo 'f cn oo eo oo ro cM θ θ θ ιn ∞

N ι o ^ ιn ^^ « (η d o m tη d o m M w ^ ^ oo o ι Hr ι d o o3 ιn d n ιJl ^ α) O Φ Λ (n (»l ^ H ιn c^ (lo co 'ι^, ^ ^n cxι (Jι (Λ d co ιn d ιn (η oι o ι fθ ιn "f Φ θ "» ιc tJi ω ιη ^ "j t^ Φ tnΦ ιn o Φ ^ ιnσi N ω n H θ tn "ϊ N Φ θ H H co <rι ιn ιn ι ι '» Φ σi H θ r- ω Φ θ "i^, H H in ιn H in

■t_f -t_f 'r in -^ in cD in in in in co oo oo cD CD in D iD i in in 't_f r^ oo r^ oo cn d C C r o OT oo o o o cD oo i^ d "t_f in ιn ιn ιn ιn ιn ιn ιn ιn ιn ιr) in ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn co co co cD iD Ln ιn cD CD iD Ln ιn ιn cD co ιo ι^ ra m « ιn r- 'tf ln o

CN CM

"^ ^ '<l^, ^ "ιι^, ^ 1' ^ » f ιn ι ιn tn ιn ιn ιn Φ Φ Φ Φ Φo^■ ^ r- ^ ^ ^ ^ ^ ^ c oo co ωco ω (D OD σι m mfl w o o o oo ooo ri H H ri H d CM CM CM CN CM CN CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CN CN CM CN CM CM C^ oo oo m oo oo oo ro ro ro ro oo ro oo oo ro oo oo ro eo ro oo oo oo ro ro ro oo oo oo co ro oo oo co oo ro M o oo oo oo oo oo oo ro ro ro ro ro oo oo oo ro ro ro oo eo ro ro co oo ro oo oo oo oo oo oo ro oo oo ro ro oo n oo oo ro ro oo M ι< D D D D DD D D D a a a a a a a D D D D D DD D tl⁾ t⁽l W I⁽l⁽n Bt⁽lti) tnt⁽lD D DD D D D - Ue . l5 t32222 Z 2Z2 Hl H¹ ιJ ιJ Hl

^ a H H H Ha Ha H Ha Ha tf tf tf tf tf tf tf ω ω ω cd d i-i fai ω M H M M ri H M H M H ω ω ω ω ω ω ω ω a a a a a co co o co co c co co tf tf tf tf tf tf o o o o o o o > > > > > > > H H Hi Ha H H iH H a a a B H μi Ha Ha H H ι-i Ha tf tf tf tf tf tf tf tf tf tf tf tf tf > > > > > d CM d CM CM d d CM d CM d CM d CM tf a Ω a fai tfaocj tf ΩΩ tf acjΩΩωcxi tf acjΩΩ tf a tf acjΩΩ tf a c o o z υ o o o o o o o zoυoυoozoυυυoυoz υυυυzozυozoooooυozυoυozυoυoz o o z o o υ υ

so rH

2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H EH H H H EH EH EH EH EH EH EH EH EH EH H H EH EH H EH H H H H EH H EH H H EH EH H EH EH H EH EH H EH EH EH EH H H EH EH H EH EH H EH EH H EH H EH H EH H EH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

O

ddoencncn∞ooι^Ln_"tf _"tf -roooooooo m « ι ιn ιn ι 0 ( H

'τ ιn oo _> co _>

(π ^ O ( ι ^ ΛΦ o ^ ιn ^ ω Φ o tη oω (Λ t^ι ιn (N Ol tD (^ ffl o N (Jl Λ H Φ H ιn Φ "τ o m n ιn ^ ^ fπ co o Φ ιη ^ ol m t^ o v 'p ra "^ H ^ o „ H O ι ra o ω ιn ^l (J c ι ^- o ι^ t<) ιn d ^ (^ <D '» d N r- ιn !D ιn "I ω Φ O - m m ^^,l ιn co co o H ^ ι ^lι ^ Φ σ^ ^ ι fl o^ H o ιn ιn ■^^, l^ (^ι ι) O ^ u^ "lι ^ oo ιn Φ ιJι d ^ ιn (O O O (») ^ι O ffl r• "^^, 0 (^,) ιn o co (») H O ιn ^ ιn "ι^, ι ιio ^ι ^ ^

Ln ιn ιn co oo oo cD ιn r^ cD r~ p- oo iD oo co r~ ιo ιn r^ r^ oo oo cn o oo co tn ιn ^ ^ ιn ιn ιn co cM co cM CM CM CM θ θ cn co ∞ ro ro ro ro ro ro ro oo oo oo n oo oo ro ro ro co ro ro oo oo oo ro o "tf oo oo oo oo ro ro oo oo oo c oo oo ro ro r^

d CM CN CM CM CMC r m r coro o c^ cθ 'tf "tf 'tf «tf «tf "tf ^ ^ 'tf i ιn ιn ιn ιnι L o D Dco o o oocoro oororo ncoooro oooo nrorooooooo oocOfo n ooro ooco rooo Moomooroooro ooro roooco noorooomroro rococ roooco oororo ooooro roro noo rooororoconcororo roro oooooor^ ro ro oooo oo oooororooorooo oooo oororo oo oo oo ro roeo ro oo oo oooo ro oo oo oororoooooro oooo oooo oo oo oo oo oo oo oo oo ro oo oo oo oooo ro roro ro oo ro

HaHaaaaa aωωωfaiωωfaiωωfai xiDDDDDDDDDaaaaaaaatf tf tf tf tf xx xDDD DDDODaaaaaaa <Λ;ωι,[jut,waaaaa aaBa daaaHiaaaHitnnnt(iwncomajaaaatiaaaaaaHiajHia>H H H ι>H>ι H >>coacocococoaaaaaaaaaaaoo o o ootf tf tf tf tf tf tf tf tf tf tf tf tf o cjcjcjc ocjEHEHEHEHEHEHEH d CM d CM d CM tf a CJ tf a CJ Ω Ω fal Cxl CO tf a CJ Ω ω a tf a CJ Ω Ω tfo tf a o Ω a a tf a cj Ω fa] Ω oozυoooo υoυoooυυυoz O O O O O O O z υ υ o o o o oz tfoaυoozo o z o υ o o o o o z υ o o υ o υ

00 rH MS 2222222222222222222222222222222222222222222222222222222222222 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

EH EH H H H H EH EH H EH H EH EH EH H EH EH EH H EH EH EH EH EH EH EH H EH H EH EH H EH EH EH EH EH EH H H EH EH EH EH EH EH H EH H EH EH EH EH EH EH EH EH EH EH EH EH

© tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

CM CM CM CM CM

d ∞ d in ∞ ro co rθ " cn cN in cN _> ro θ 'tf co r"-- co cΩ "tf »tf tn cn cM cn oo cN co co cn M c CM r~ d cM "tf d c r- r o ι^ cM r--- d σι oo o ιn r~ r^ d o cN in co co cn c t^ oo o r~ θ '^ ι cN i o cN r~ d ^

^ ^ ^ ^ o m ( αι tD Hf ι ^ oo ι ^ d r- ^ m d ^^ >J H H d ^^ Φ d O N O ιη Hf (^l 'l^| co (0 ( ιn d o o (D O O d d Ol oD ιn t)l tη φ "J ^^ ^ u^ d θ θ cn cn o o o oo θ CM ro cM 't_f ^r rθ 't_f CD 'a' τ -1" "tf θo ιn co r^ ιo r^ r^ r~ vD cD ∞ cn o cn o o cn cn cn o crι d o cM CN cn cn cn r- -- co oo o cD in cD in ιn cD d d d d d d d d d d d d d CM d CM CM d d d CM d CN CM CM CN d d d d d d d CN d d d d d d ιn m NΛ o w ιn n v ^ "r tn "» π "r m o o Φ ^ ιnω N θ cvι m Φ o σι n <D σι α) "r θ H θi ιn ^ ιn ^ Φ r- ιn α) in oi "if tιor- mo ^^, o ΦΦ ω ιn ^ o ιn ^η co ^ σι H σι H H n co Φ O O l N 'f Φ ι « N N ffl n Φ co Φ (n ^ ιn l O N ri ^ fn ι ^ ^ oo oo O '» Φ m ^ Φι t- N Cfι e oo 'tf θ o cM CD c oD θ oo oo ιn M ^ ιn ιn cN CN r^ o o ∞ d ( j oo r~ oo o ι in c cD σ "tf CN d cM 'tf θ D cN in o r~

*tf m co cN CM d o oo oo r- o oo o α oo o^ o o Φ ιn n (') (^,1 ιn Φ ι ^ ι t'l tn (ι ^^ o o w co ιJl σι ω o t-- ^ ιn 'f ^ ^ t^Il ιn ιn ιn ιnm ι ιn ^ Φ ω ro i/i ifi in ui i/i iJi in ^ ii' it iri ¹ in 'tf ^,tf 'tf in in 'tf "tf "tf "tf 'tf ^ 'r 'tf "tf 'tf 'r 'tf 'r "tf ^ ^ "tf OO oo oo oo O "tf oo oo o o r r c r ro ro ro c M e o o cM cn cM d ro co oo ro ιn oo ιn ιn cM d cn r^ d CM θ rθ 'tf -' ro co r~ d o r^ σv 'τ oo cθ "tf CM ι~ ^ r--- oo oo co σι o cD ∞ o in cn co o co cN o r^ in ro ro in cn oo co tn cn co cΩ in cM CM CN CM in in σϊ cn r^

0 (η ιn N H O N O H ^ Φ < m t ( m d oo n "^ o ^ oo ^^ (^ι ^ ^n o N ^ ( l ι f m ι- ω o π ^ a) oo ^ι oo o tN tη σι (^») o ιn c^ι n o o o o d ιn "J ιn "J "f ^ lη c1 "r N d H O O O H H N C n H O Ol (o r- ∞ ι ι tI) tx! ^ to Φ 'l^{, (}^ (^,) tn Φ Φ ιn ι ιn ^ ιn ιn 'l' t H H d 'l' ^ "^ ιn r rO rO rO CN CM CM CM CM CM CM CM CN CN CN CN CM CM CM CN CM CM CM CM CM CN CM d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d C

ooooc oo a aaa aa a a a a aacococococoaDDDDDDDD tf tf tf tf tf xxx xz z z z z zz zoSosa aaa c-i ωcxiw w cxiw cxi x x xx

>^ι < ^H>^ι < aaaBaa ^ι H>< ^ι H>^ιt-iιiiι]ωi^jωω ωHia a aaaa awnMwnM⁽tno[-HW(,wiιiaaaaaaaaa aaa H H H H H H H EH EH H H H O OOO Ona iJHa iH H H Ha Ha tf tf tf tf tf OOO CJ tf tf tf tf tf tf tf tf WWWacO COH MMH HHMHC JCJCJ tf o oo zoυ υcozoooooo o z υυoozooozoυoozυo z υ υ o o o υυooυoozυoo

^•^ ιn o r^ ∞ cn o d CN rθ "^ θ o ι^ rø c o d C rθ "tf i ιo r~ ∞ σι θ CN θθ ^ ιn _^ d d d d d d c CM CM CM CM CM CM CM CM CM r e co M ro r oo oo o -^ -tf 'tf ^ 'r 'r 'tf ^ ^ ^ in in i i in in in i in in c^

OO OO OO CO CO OO CO CO OO OD CO OO OO OO CO CO CO CO CO CO CO CO OO OO OO OO OO OO OO OO OO OO OO CO OO CO OO CO OO OO CO OO ∞

— P "tf "tf ¹ 1" "tf 'tf ^¹ "tf ^¹ ^ Jⁱ ^ⁱ ^ⁱ —lⁱ — T ' Ji ^i ^Ji — Ji "3i — Ji "3i — P '^i 'Ji 'Ji .qi — P ' ^ 1" "tf 1* ' J¹ I¹ 1" ' r 1" "tf "tf ' 3" — I¹ — P 1" - li ^i ^i -Ji — 1" — ϊi ^i ^i — r — p — |i — 11 — |i — r ^ji ^i — p ^i

00 se rH 2222222222222222222222222222222222222222222222222222222222222 rH OOOOOOOO OOOOOO OOOOO O O OO O O O OOOOOOOOOOOOOO OO O O O O O O O O O O O O O OO O O O O © EH EH EH EH EH H EH EH EH EH EH EH EH EH EH EH H H EH EH EH EH EH EH H EH EH EH EH EH EH EH EH EH EH EH EH EH EH H EH EH EH EH EH EH H EH EH EH EH EH EH EH H EH EH EH EH EH EH tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o

cN eo in d c cN d oo o in . inw ω H u ω t 'M- N i¹

ooooooooooo ooooooooooo

ιη o ra ^ ι ra ^^ „ w o m ^ n on r ι 'J O nΦ Φ ιn ω N _ n α) H O ri N W ^ O Φ ω ιn H ^ H "I (J o ^ ' H ^ Φ ιη(η o _ ιη lnO "l' O H o ιn oo cN oo o co r- CN r~ ∞ ∞ CN θ ι~ r~ o oo ιn r~ r~ CN ro ra ro cN θ co ιn ro o d -θ - -w oo H m 'r Φ co o Φ n n Λ H ιn Φ N •!^ (Il N (Λ Φ n o Φ ^ c^ι o H "l^| ri tη ιη σι Φ oo 'ιι^ι o ^ ^ H o ιn co Φ O O <I H ri 'l^| H Ol "* ^ 'ϊ ^ ιn oo oo o cn m o oo o ^l (o n π 7 ^ ιn ιn ιn ιn n ^ ^ ^ oΛ o o <Il o m o o oH o m ιη ^η tη ln ι Hl^ι φ ^ φ ^ Φ co ι "^' ιB ^ co o oo o oo -^ o r ^ oo ^ "tf "tf "tf " 'τ ^ 'tf 'r "tf ' 'tf "tf ^ "tf ^ ^ ^ ^ ^ ι ιn ' -o ιn ^ ιn L Lθ L L^ eo ιn

cn cn cncn cn cncn cnoo ooo o d d d d d dd d d dCN CN CMCMCN CN CN CM CMCM roooro roro rO 'tf 'tf 'tf 'tf 'r in i^ 'tf 'tf -r -r 'r '^ 'tf ^ in-Oi ininin in ininin in in -o in in ini L in in i^ c c rorococo oooo oo o ro m roro ro rorooo rooo oo ro oo ooro ooro ooro rooo oo oooo oocororo ro ooro oo ooroo^ oocooo roro ro rooo oo rooo oo roro oo ooro ro oooo oo oo oo oo oo ooro ooco oooo oO Mco oororoM oo oDooooc-J a aa a a cocoacococ c c c c aco wcoacococ c coa aa aa a tf tf tf tf aaa CMaaaaaaaaaaaa a aa aa DD ωw ωωωω ωω i ω aω w wM H MM H H H H HHH H H H H H ω ωω ωω ω H-J Ha HH Ha a a a a a a a a a jaa jaaa anwtQnnwa a aa a aa aa aaa aaaaaaaxnwoiwwtn tf tf tf tf EH EH EH -H H EH EH EH H H

CM CM d d CM CM d d CM CN CN OO d d C CO CM tf a CJ Ω Ω tf acj tf acjΩΩwω tf a Ω Wfai tf ao tf a tf a cj Ω a w Ω i ro co a tf zoυυυυυo zυυoυozυooυzυzoozυυυυzυzoozoooυoz υυoozooυυυυυzoooυozυ ι<) "qι

00 rH

2o2oo22o2oo22o2oo2o2o2o2o22oo2o22o2oo2o22o2o o 2o22oo2o2o2o2o22oo22o2oo22oo22oo2o22oo2o22o2oo22o2oo22oo22oo2 22222222 OOOOOOOO tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf o tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf tf

Table 2

27.968 59.567 7. 987 1.00 26.37

ATOM 4936 CB LEU 3356

28.642 60.839 8. 517 1.00 26.66

ATOM 4937 CG LEU 3356

27.578 61.699 9. 187 1.00 25.57

ATOM 4938 CDl LEU 3356

29.746 60.490 9. 505 1.00 25.10

ATOM 4939 CD2 LEU 3356

LEU 3 3335566 28.003 60.498 5. 710 1.00 23.94

ATOM 4940 C

29.026 59.954 5. 285 1.00 20.62

ATOM 4941 0 L LEEUU 3 3335566

27.598 61.683 5. 307 1.00 26.42

ATOM 4942 N T THHRR 3 3335577

28.376 62.416 4. 323 1.00 26.09

ATOM 4943 CA THR 3 3335577

3335577 27.459 63.010 3. 267 1.00 25.60

ATOM 4944 CB THR 3

26.573 61.984 2. ,793 1.00 30.06

ATOM 4945 OGl THR 3357

28.265 63.514 2. ,110 1.00 26.38

ATOM 4946 CG2 THR 3357

29.198 63.499 4. .993 1.00 23.29

ATOM 4947 C THR 3357 OM 0 THR 3357 28.696 64.243 5, .836 1.00 21.43

AT 4948

30.465 63.579 4, .618 1.00 20.55

ATOM 4949 N VAL 3358

31.325 64.568 5 .231 1.00 22.35

ATOM 4950 CA VAL 3358

4951 CB VAL 3358 32.469 63.889 5 .973 1.00 23.52

ATOM 33.132 64.901 6 .887 1.00 24.27

ATOM 4952 CGI VAL 3358

31.934 62.693 6 .755 1.00 20.28

ATOM 4953 CG2 VAL 3358

31.880 65.595 4 .248 1.00 22.21

ATOM 4954 C VAL 3358

32.343 65.253 3 .155 1.00 16.76

ATOM 4955 o VAL 3358

31.834 66.863 4 .661 1.00 24.15

ATOM 4956 N LEU 3359

67.973 3 .822 1.00 25.25

ATOM 4957 CA LEU 3359 32.276

68.821 3 .465 1.00 21.53

ATOM 4958 CB LEU 3359 31.050

4959 CG LEU 3359 29.968 68.004 2 .752 1.00 20.11

ATOM 68.857 2 .488 1.00 18.40

ATOM 4960 CDl LEU 3359 28.734

67.447 1 1 ..448 1.00 16.31

ATOM 4961 CD2 LEU 3359 30.553

68.851 4 4 .404 1.00 26.37

ATOM 4962 C LEU 3359 33.383

69.014 5 5ι..644 1.00 31.30

ATOM 4963 0 LEU 3359 33.406

24.099 44.777 1.00 72.77

ATOM 4964 S S04 4000 5. .633 4000 4. .278 23.915 44.236 1.00 73.25

ATOM 4965 Ol S04

23.359 43.945 1.00 72.28

ATOM 4966 02 S04 4000 6.603

25.529 44.784 1.00 72.55

ATOM 4967 03 S04 4000 5.958

23.586 46.157 1.00 75.61

ATOM 4968 04 S04 4000 5.678

21.084 46.120 1.00 83.74

ATOM 4969 5 S04 4001 10.965

21.413 47.103 1.00 84.81

ATOM 4970 01 S04 4001 12.014

19.741 45.559 1.00 83.81

ATOM 4971 02 S04 4001 11.205

21.112 46.776 1.00 83.46-

ATOM 4972 03 S04 4001 9.641 8 22.071 45.032 1.00 84.3.1

ATOM 4973 04 S04 4001 11.00

-2.986 74.153 -11.455 1.00 58.62

ATOM 4974 S S04 4002

-1.886 73.544 -12.230 1.00 56.25

ATOM 4975 01 S04 4002

-3.387 73.255 -10.356 00 57.05

ATOM 4976 02 S04 4002

-2.542 75.460 -10.941 00 59.05

ATOM 4977 03 S04 4002

S04 4002 -4.157 74.370 -12.323 00 63.86

ATOM 4978 04

0.500 75.090 -5.675 00 41.03

ATOM 4979 S S04 4003

0.983 74.248 -6.786 00 39.49

ATOM 4980 01 S04 4003

0.212 74.253 -4.505 1.00 44.82

ATOM 4981 02 S04 4003

1.532 76.084 -5.344 1.00 46.05

ATOM 4982 03 S04 4003

-0.732 75.799 -6.055 1.00 44.94

ATOM 4983 04 S04 4003

Table 3

Table 3 FGFR2(D2-D3) Complexed with FGF2

HEADER GROWTH FACTOR/GROWTH FACTOR RECEPTOR 19-APR-00 1EV2

TITLE CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR

TITLE 2 LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)

COMPND MOL D: 1;

COMPND 2 MOLECULE: FIBROBLAST GROWTH FACTOR 2;

COMPND 3 CHAIN: A, B, C, D;

COMPND 4 FRAGMENT: THE B-TREFOIL CORE OF FIBROBLAST GROWTH FACTOR 2;

COMPND 5 SYNONYM: FGF2;

COMPND 6 ENGINEERED: YES;

COMPND 7 MUTATION: YES;

COMPND 8 MOLJD: 2;

COMPND 9 MOLECULE: FIBROBLAST GROWTH FACTOR RECEPTOR 2;

COMPND 10 CHAIN: E, F, G, H;

COMPND 11 FRAGMENT: EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF

COMPND 12 RECEPTOR 2 CONSISTING OF IMMUNOGLOBULIN LIKE DOMAINS II

COMPND 13 (D2) AND III (D3);

COMPND 14 SYNONYM: FGFR2;

COMPND 15 ENGINEERED: YES

SOURCE MOLJD: 1;

SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;

SOURCE 3 ORGANISM COMMON: HUMAN;

SOURCE 4 EXPRESSION_SYSTEM_COMMON: BACTERIA;

SOURCE 5 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;

SOURCE 6 EXPRESSION_SYSTEM_PLASMID: PET15B;

SOURCE 7 MOLJD: 2;

SOURCE 8 ORGANISM_SCIENTIFIC: HOMO SAPIENS;

SOURCE 9 ORGANISM_COMMON: HUMAN;

SOURCE 10 EXPRESSION_SYSTEM_COMMON: BACTERIA;

SOURCE 11 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;

SOURCE 12 EXPRESSION_SYSTEM_PLASMID: PET28A

KEYWDS IMMUNOGLOBULIN (IG)LKE DOMAINS BELONGING TO THE I-SET

KEYWDS 2 SUBGROUP WITHIN IG-LKE DOMAINS, B-TREFOIL FOLD

EXPDTA X-RAY DIFFRACTION

AUTHOR A.N.PLOTNIKOV,S.R.HUBBARD,J.SCHLESSINGER,M.MOHAMMADI

REVDAT 1 31-MAY-00 1EV2 0

JRNL AUTH A.N.PLOTNIKOV,S.R.HUBBARD,J.SCHLESSINGER,

JRNL AUTH 2 M.MOHAMMADI

JRNL TITL CRYSTAL STRUCTURES OF TWO FGF-FGFR COMPLEXES

JRNL TITL 2 REVEAL THE DETERMINANTS OF LIGAND-RECEPTOR

JRNL TITL 3 SPECIFICITY

JRNL REF CELL (CAMBRIDGE.MASS.) V. 101 413 2000

JRNL REFN ASTM CELLB5 US ISSN 0092-8674

REMARK 1

REMARK 2

REMARK 2 RESOLUTION. 2.2 ANGSTROMS.

REMARK 3

REMARK 3 REFINEMENT.

REMARK 3 PROGRAM : CNS

REMARK 3 AUTHORS : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-

REMARK 3 : KUNSTLEVE.JIANG.KUSZEWSKI.NILGES, PANNU,

REMARK 3 : READ.RICE.SIMONSON.WARREN Table 3

REMARK REMARK REFINEMENT TARGET : ENGH & HUBER REMARK REMARK DATA USED IN REFINEMENT. REMARK RESOLUTION RANGE HIGH (ANGSTROMS) : 2.20 REMARK RESOLUTION RANGE LOW (ANGSTROMS) : 25.00 REMARK DATA CUTOFF (SIGMA(F)) : 0.000 REMARK OUTLIER CUTOFF HIGH (RMS(ABS(F))) : NULL REMARK COMPLETENESS (WORKING +TEST) (%) : 91.7 REMARK NUMBER OF REFLECTIONS : 84816 REMARK REMARK REMARK FIT TO DATA USED IN REFINEMENT. REMARK CROSS-VALIDATION METHOD : NULL REMARK FREE R VALUE TEST SET SELECTION : RANDOM REMARK R VALUE (WORKING SET) : 0.248 REMARK FREE R VALUE : 0.273 REMARK FREE R VALUE TEST SET SIZE (%) : NULL REMARK FREE R VALUE TEST SET COUNT : 4291 REMARK ESTIMATED ERROR OF FREE R VALUE : NULL REMARK REMARK FIT IN THE HIGHEST RESOLUTION BIN. REMARK TOTAL NUMBER OF BINS USED : NULL REMARK BIN RESOLUTION RANGE HIGH (A) : NULL REMARK BIN RESOLUTION RANGE LOW (A) : NULL REMARK BIN COMPLETENESS (WORKING+TEST) (%) : NULL REMARK REFLECTIONS IN BIN (WORKING SET) : NULL REMARK BIN R VALUE (WORKING SET) : NULL REMARK BIN FREE R VALUE : NULL REMARK BIN FREE R VALUE TEST SET SIZE (%) : NULL REMARK BIN FREE R VALUE TEST SET COUNT : NULL REMARK ESTIMATED ERROR OF BIN FREE R VALUE : NULL REMARK REMARK NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK PROTEIN ATOMS : 9818 REMARK NUCLEIC ACID ATOMS : 0 REMARK HETEROGEN ATOMS : 20 REMARK SOLVENT ATOMS : 263 REMARK REMARK B VALUES. REMARK FROM WILSON PLOT (A**2) : NULL REMARK MEAN B VALUE (OVERALL, A**2) : NULL REMARK OVERALL ANISOTROPIC B VALUE. REMARK B11 (A**2) : -14.90300 REMARK B22 (A**2) : -0.98800 REMARK B33 (A**2) : 15.89200 REMARK B12 (A**2) : 0.00000 REMARK B13 (A**2) : 0.00000 REMARK B23 (A**2) : -0.65800 REMARK REMARK ESTIMATED COORDINATE ERROR. REMARK ESD FROM LUZZATI PLOT (A) : NULL REMARK ESD FROM SIGMAA (A) : NULL REMARK LOW RESOLUTION CUTOFF (A) : NULL REMARK Table 3

REMARK 3 CROSS-VALIDATED ESTIMATED COORDINATE ERROR. REMARK 3 ESD FROM C-V LUZZATI PLOT (A) : NULL REMARK 3 ESD FROM C-V SIGMAA (A) : NULL REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES. REMARK 3 BOND LENGTHS (A) : 0.007 REMARK 3 BOND ANGLES (DEGREES) : 1.33 REMARK 3 DIHEDRAL ANGLES (DEGREES) : NULL REMARK 3 IMPROPER ANGLES (DEGREES) : 0.78 REMARK .3 REMARK 3 ISOTROPIC THERMAL MODEL : NULL REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. RMS SIGMA REMARK 3 MAIN-CHAIN BOND (A**2) : 0.87 ; 1.500 REMARK 3 MAIN-CHAIN ANGLE (A**2) : 1.53 ; 2.000 REMARK 3 SIDE-CHAIN BOND (A**2) : 1.16 ; 2.000 REMARK 3 SIDE-CHAIN ANGLE (A**2) : 1.79 2.500 REMARK 3 REMARK 3 REMARK 3 BULK SOLVENT MODELING. REMARK 3 METHOD USED : CNS REMARK 3 KSOL : 0.38 REMARK 3 BSOL : 47.84 REMARK 3 REMARK 3 NCS MODEL : NULL REMARK 3 REMARK 3 NCS RESTRAINTS. RMS SIGMA/WEIGHT REMARK 3 GROUP 1 POSITIONAL (A) : NULL ; NULL REMARK 3 GROUP 1 B-FACTOR (A**2) : NULL ; NULL REMARK 3 REMARK 3 PARAMETER FILE 1 : NULL REMARK 3 TOPOLOGY FILE 1 NULL REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: NULL REMARK 4 REMARK 4 1EV2 COMPLIES WITH FORMAT V. 2.3, 09-JULY-1998 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 26-APR-2000. REMARK 100 THE RCSB ID CODE IS RCSB010917. REMARK 200 REMARK 200 EXPERIMENTAL DETAILS REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION : 22-SEP-1999 REMARK 200 TEMPERATURE (KELVIN) : 110.0 REMARK 200 PH : 7.50 REMARK 200 NUMBER OF CRYSTALS USED : 1 REMARK 200 REMARK 200 SYNCHROTRON (Y/N) : Y REMARK 200 RADIATION SOURCE : NSLS REMARK 200 BEAMLINE : X4A REMARK 200 X-RAY GENERATOR MODEL : NULL REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M REMARK 200 WAVELENGTH OR RANGE (A) : 0.9789 REMARK 200 MONOCHROMATOR : NULL REMARK 200 OPTICS : NULL Table 3 REMARK 200

REMARK 200 DETECTOR TYPE : CCD

REMARK 200 DETECTOR MANUFACTURER : SDMS

REMARK 200 INTENSITY-INTEGRATION SOFTWARE : SDMS REMARK 200 DATA SCALING SOFTWARE : SCALEPACK

REMARK 200

REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 206913 REMARK 200 RESOLUTION RANGE HIGH (A) : 2.200 REMARK 200 RESOLUTION RANGE LOW (A) : 25.000 REMARK 200 REJECTION CRITERIA (SIGMA(I)) : 0.000 REMARK 200 REMARK 200 OVERALL.

REMARK 200 COMPLETENESS FOR RANGE (%) : 96.3 REMARK 200 DATA REDUNDANCY : 2.200

REMARK 200 R MERGE (I) : 0.04200

REMARK 200 R SYM (I) : NULL

REMARK 200 < I/SIGMA(I) > FOR THE DATA SET -. 16.3000 REMARK 200

REMARK 200 IN THE HIGHEST RESOLUTION SHELL. REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.20 REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 2.28 REMARK 200 COMPLETENESS FOR SHELL (%) : 87.8 REMARK 200 DATA REDUNDANCY IN SHELL : NULL REMARK 200 R MERGE FOR SHELL (I) : 0.24100

REMARK 200 R SYM FOR SHELL (I) : NULL

REMARK 200 <I/SIGMA(I) > FOR SHELL : NULL

REMARK 200

REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: NULL REMARK 200 SOFTWARE USED: AMORE REMARK 200 STARTING MODEL: NULL REMARK 200

REMARK 200 REMARK: NULL REMARK 280 REMARK 280 CRYSTAL

REMARK 280 SOLVENT CONTENT, VS (%): NULL

REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): NULL REMARK 280

REMARK 280 CRYSTALLIZATION CONDITIONS: PEG 4000, ISOPROPANOL, HEPES- REMARK 280 NAOH REMARK 290

REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 REMARK 290

REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X,Y,Z REMARK 290

REMARK 290 WHERE NNN - > OPERATOR NUMBER REMARK 290 MMM - > TRANSLATION VECTOR

REMARK 290

REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. Table 3

REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 REMARK 290 REMARK: NULL REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT REMARK 300 WHICH CONSISTS OF 8 CHAIN(S). SEE REMARK 350 FOR REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S). REMARK 350 REMARK 350 GENERATING THE BIOMOLECULE REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H

REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000

REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000

REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000

REMARK 465

REMARK 465 MISSING RESIDUES

REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE

REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN

REMARK 465 IDENTIFIER; SSSEQ= SEQUENCE NUMBER; I=INSERTION CODE.)

REMARK 465

REMARK 465 M RES C SSSEQI

REMARK 465 GLY A 15

REMARK 465 SER A 146

REMARK 465 GLY B 15

REMARK 465 SER B 146

REMARK 465 GLY C 15

REMARK 465 SER C 146

REMARK 465 GLY D 15

REMARK 465 SER D 146

REMARK 465 ASN E 147

REMARK 465 SER E 148

REMARK 465 ASN E 149

REMARK 465 THR E 268

REMARK 465 VAL E 269

REMARK 465 VAL E 270

REMARK 465 GLY E 271

REMARK 465 GLY E 272

REMARK 465 GLU E 295

REMARK 465 LYS E 296

REMARK 465 ASN E 297

REMARK 465 GLY E 298

REMARK 465 SER E 299

REMARK 465 LYS E 300

REMARK 465 TYR E 301

REMARK 465 GLY E 302

REMARK 465 PRO E 303 Table 3

REMARK 465 ASPE 304

REMARK 465 GLYE 305

REMARK 465 LEUE 306

REMARK 465 PROE 361

REMARK 465 ALAE 362

REMARK 465 PROE 363

REMARK 465 GLYE 364

REMARK 465 ARGE 365

REMARK 465 GLUE 366

REMARK 465 ASNF 147

REMARK 465 SERF 148

REMARK 465 ASNF 149

REMARK 465 GLYF 272

REMARK 465 VALF 294

REMARK 465 GLUF 295

REMARK 465 LYSF 296

REMARK 465 ASNF 297

REMARK 465 GLYF 298

REMARK 465 SERF 299

REMARK 465 LYSF 300

REMARK 465 TYRF 301

REMARK 465 GLYF 302

REMARK 465 PROF 303

REMARK 465 ASPF 304

REMARK 465 GLYF 305

REMARK 465 LEUF 306

REMARK 465 PROF 307

REMARK 465 LEUF 360

REMARK 465 PROF 361

REMARK 465 ALAF 362

REMARK 465 PROF 363

REMARK 465 GLYF 364

REMARK 465 ARGF 365

REMARK 465 GLUF 366

REMARK 465 ASNG 147

REMARK 465 SERG 148

REMARK 465 ASNG 149

REMARK 465 ASNG 150

REMARK 465 GLUG 295

REMARK 465 LYSG 296

REMARK 465 ASNG 297

REMARK 465 GLYG 298

REMARK 465 SERG 299

REMARK 465 LYSG 300

REMARK 465 TYRG 301

REMARK 465 GLYG 302

REMARK 465 PROG 303

REMARK 465 ASPG 304

REMARK 465 GLYG 305

REMARK 465 LEUG 306

REMARK 465 PROG 307

REMARK 465 GLYG 364

REMARK 465 ARGG 365

REMARK 465 GLUG 366

REMARK 465 ASNH 147 Table 3

REMARK 465 SERH 148 REMARK 465 ASNH 149 REMARK 465 ASNH 150 REMARK 465 GLUH 295 REMARK 465 LYSH 296 REMARK 465 ASNH 297 REMARK 465 GLYH 298 REMARK 465 SERH 299 REMARK 465 LYSH 300 REMARK 465 TYRH 301 REMARK 465 GLYH 302 REMARK 465 PROH 303 REMARK 465 ASPH 304 REMARK 465 GLYH 305 REMARK 465 LEUH 306 REMARK 465 GLYH 364 REMARK 465 ARGH 365 REMARK 465 GLUH 366 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS(M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I INSERTION CODE): REMARK 470 MRESCSSEQI ATOMS REMARK 470 HIS A 16 CG ND1 CD2 CE1 NE2 REMARK 470 ARG A 39 CG CD NE CZ NH1 NH2 REMARK 470 GLU A 45 CG CD OEl OE2 REMARK 470 LYS A 46 CG CD CE NZ REMARK 470 SERA 47 OG REMARK 470 ARG A 72 CG CD NE CZ NH1 NH2 REMARK 470 LYS A 77 CG CD CE NZ REMARK 470 GLU A 78 CG CD OEl OE2 REMARK 470 ARG A 81 CG CD NE CZ NH1 NH2 REMARK 470 LYS A 86 CG CD CE NZ REMARK 470 GLU A 91 CG CD OEl OE2 REMARK 470 LYS A 110 CG CD CE NZ REMARK 470 TRP A 114 CG CDl CD2 NEl CE2 CE3 CZ2 REMARK 470 TRP A 114 CZ3 CH2 REMARK 470 LYS A 119 CG CD CE NZ REMARK 470 ARG A 120 CG CD NE CZ NH1 NH2 REMARK 470 LEU A 126 CG CDl CD2 REMARK 470 LYS A 129 CG CD CE NZ REMARK 470 LYS A 145 CG CD CE NZ REMARK 470 HISB 16 CG ND1 CD2 CE1 NE2 REMARK 470 LYSB 46 CG CD CE NZ REMARK 470 HISB 50 CG ND1 CD2 CE1 NE2 REMARK 470 LYSB 52 CG CD CE NZ REMARK 470 LYSB 77 CG CD CE NZ REMARK 470 GLUB 78 CG CD OEl OE2 REMARK 470 ARGB 81 CG CD NE CZ NH1 NH2 REMARK 470 LYSB 86 CG CD CE NZ REMARK 470 GLUB 91 CG CD OEl OE2 REMARK 470 LYSB 110 CG CD CE NZ REMARK 470 TYR BUI CG CDl CD2 CE1 CE2 CZ OH REMARK 470 TRP B 114 CG CDl CD2 NEl CE2 CE3 CZ2 Table 3

REMARK 470 TRP B 114 CZ3 CH2

REMARK 470 LYS B 119 CG CD CE NZ

REMARK 470 ARG B 120 CG CD NE CZ NHl NH2

REMARK 470 GLN B 123 CG CD OEl NE2

REMARK 470 LEU B 126 CG CDl CD2

REMARK 470 LYS B 145 CG CD CE NZ

REMARK 470 HIS C 16 CG ND1 CD2 CEl NE2

REMARK 470 HIS C 35 CG ND1 CD2 CEl NE2

REMARK 470 ARG C 39 CG CD NE CZ NHl NH2

REMARK 470 GLU C 45 CG CD OEl OE2

REMARK 470 LYS C 46 CG CD CE NZ

REMARK 470 SER C 69 OG

REMARK 470 GLU C 78 CG CD OEl OE2

REMARK 470 ARG C 81 CG CD NE CZ NHl NH2

REMARK 470 LYS C 86 CG CD CE NZ

REMARK 470 ASN C 101 CG OD1 ND2

REMARK 470 ARG C 120 CG CD NE CZ NHl NH2

REMARK 470 LYS C 129 CG CD CE NZ

REMARK 470 LYS C 145 CG CD CE NZ

REMARK 470 HIS D 16 CG ND1 CD2 CEl NE2

REMARK 470 HIS D 35 CG ND1 CD2 CEl NE2

REMARK 470 GLU D 45 CG CD OEl OE2

REMARK 470 LYS D 46 CG CD CE NZ

REMARK 470 ASP D 48 CG OD1 OD2

REMARK 470 SER D 69 OG

REMARK 470 GLU D 78 CG CD OEl OE2

REMARK 470 ARG D 81 CG CD NE CZ NHl NH2

REMARK 470 LYS D 86 CG CD CE NZ

REMARK 470 SER D 87 OG

REMARK 470 LYS D 119 CG CD CE NZ

REMARK 470 ARG D 120 CG CD NE CZ NHl NH2

REMARK 470 LYS D 129 CG CD CE NZ

REMARK 470 LYS D 145 CG CD CE NZ

REMARK 470 ASN E 150 CG OD1 ND2

REMARK 470 LYS E 151 CG CD CE NZ

REMARK 470 GLU E 160 CG CD OEl OE2

REMARK 470 LYS E 161 CG CD CE NZ

REMARK 470 GLU E 163 CG CD OEl OE2

REMARK 470 ASN E 184 CG OD1 ND2

REMARK 470 ARG E 210 CG CD NE CZ NHl NH2

REMARK 470 ASN E 211 CG OD1 ND2

REMARK 470 GLN E 212 CG CD OEl NE2

REMARK 470 HIS E 213 CG ND1 CD2 CEl NE2

REMARK 470 GLU E 234 CG CD OEl OE2

REMARK 470 SER E 267 OG

REMARK 470 TYR E 281 CG CDl CD2 CEl CE2 CZ OH

REMARK 470 LYS E 292 CG CD CE NZ

REMARK 470 HIS E 293 CG ND1 CD2 CEl NE2

REMARK 470 VAL E 294 CGI CG2

REMARK 470 TYR E 308 CG CDl CD2 CEl CE2 CZ OH

REMARK 470 LYS E 310 CG CD CE NZ

REMARK 470 LYS E 322 CG CD CE NZ

REMARK 470 GLU E 323 CG CD OEl OE2

REMARK 470 ARG E 330 CG CD NE CZ NHl NH2

REMARK 470 ASN E 331 CG OD1 ND2 Table 3

REMARK 470 VAL E 332 CGI CG2

REMARK 470 THR E 333 OG1 CG2

REMARK 470 PHE E 334 CG CDl CD2 CEl CE2 CZ

REMARK 470 GLU E 335 CG CD OEl OE2

REMARK 470 VAL E 359 CGI CG2

REMARK 470 LEU E 360 CG CDl CD2

REMARK 470 ASN F 150 CG OD1 ND2

REMARK 470 LYS F 151 CG CD CE NZ

REMARK 470 GLU F 160 CG CD OEl OE2

REMARK 470 LYS F 161 CG CD CE NZ

REMARK 470 GLU F 163 CG CD OEl OE2

REMARK 470 ASN F 184 CG OD1 ND2

REMARK 470 ARG F 210 CG CD NE CZ NHl NH2

REMARK 470 GLN F 212 CG CD OEl NE2

REMARK 470 HIS F 213 CG ND1 CD2 CEl NE2

REMARK 470 GLU F 234 CG CD OEl OE2

REMARK 470 GLU F 236 CG CD OEl OE2

REMARK 470 SER F 267 OG

REMARK 470 VAL F 269 CGI CG2

REMARK 470 VAL F 270 CGI CG2

REMARK 470 HIS F 293 CG ND1 CD2 CEl NE2

REMARK 470 TYR F 308 CG CDl CD2 CEl CE2 CZ OH

REMARK 470 LYS F 310 CG CD CE NZ

REMARK 470 LYS F 322 CG CD CE NZ

REMARK 470 GLU F 323 CG CD OEl OE2

REMARK 470 TYR F 328 CG CDl CD2 CEl CE2 CZ OH

REMARK 470 ILE F 329 CGI CG2 CDl

REMARK 470 ARG F 330 CG CD NE CZ NHl NH2

REMARK 470 ASN F 331 CG OD1 ND2

REMARK 470 VAL F 332 CGI CG2

REMARK 470 THR F 333 OG1 CG2

REMARK 470 PHE F 334 CG CDl CD2 CEl CE2 CZ

REMARK 470 GLU F 335 CG CD OEl OE2

REMARK 470 TRP F 356 CG CDl CD2 NEl CE2 CE3 CZ2

REMARK 470 TRP F 356 CZ3 CH2

REMARK 470 THR F 358 OG1 CG2

REMARK 470 VAL F 359 CGI CG2

REMARK 470 LYS G 151 CG CD CE NZ

REMARK 470 GLU G 160 CG CD OEl OE2

REMARK 470 ARG G 165 CG CD NE CZ NHl NH2

REMARK 470 LYS G 176 CG CD CE NZ

REMARK 470 LYS G 196 CG CD CE NZ

REMARK 470 ARG G 203 CG CD NE CZ NHl NH2

REMARK 470 ARG G 210 CG CD NE CZ NHl NH2

REMARK 470 GLN G 212 CG CD OEl NE2

REMARK 470 HIS G 213 CG ND1 CD2 CEl NE2

REMARK 470 LYS G 226 CG CD CE NZ

REMARK 470 GLU G 236 CG CD OEl OE2

REMARK 470 ASP G 273 CG OD1 OD2

REMARK 470 TYR G 308 CG CDl CD2 CEl CE2 CZ OH

REMARK 470 LYS G 310 CG CD CE NZ

REMARK 470 LYS G 322 CG CD CE NZ

REMARK 470 GLU G 323 CG CD OEl OE2

REMARK 470 GLU G 335 CG CD OEl OE2

REMARK 470 LYS H 151 CG CD CE NZ Table 3

REMARK 470 GLU H 160 CG CD OEl OE2

REMARK 470 LYS H 161 CG CD CE NZ

REMARK 470 ARG H 165 CG CD NE CZ NHl NH2

REMARK 470 LYS H 176 CG CD CE NZ

REMARK 470 LYS H 196 CG CD CE NZ

REMARK 470 GLU H 197 CG CD OEl OE2

REMARK 470 LYS H 199 CG CD CE NZ

REMARK 470 ARG H 210 CG CD NE CZ NHl NH2

REMARK 470 ASN H 211 CG OD1 ND2

REMARK 470 GLN H 212 CG CD OEl NE2

REMARK 470 GLU H 236 CG CD OEl OE2

REMARK 470 HIS H 245 CG ND1 CD2 CEl NE2

REMARK 470 VAL H 269 CGI CG2

REMARK 470 HIS H 293 CG ND1 CD2 CEl NE2

REMARK 470 TYR H 308 CG CDl CD2 CEl CE2 CZ OH

REMARK 470 LYS H 310 CG CD CE NZ

REMARK 470 ASN H 318 CG OD1 ND2

REMARK 470 LYS H 322 CG CD CE NZ

REMARK 470 GLU H 323 CG CD OEl OE2

REMARK 470 PHE H 334 CG CDl CD2 CEl CE2 CZ

REMARK 470 GLU H 335 CG CD OEl OE2

REMARK 470 VAL H 359 CGI CG2

REMARK 500

REMARK 500 GEOMETRY AND STEREOCHEMISTRY

REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS

REMARK 500

REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES

REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE

REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN

REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I INSERTION CODE).

REMARK 500

REMARK 500 STANDARD TABLE:

REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),F6.3)

REMARK 500

REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991

REMARK 500

REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION

REMARK 500 MET A 76 CE MET A 76 SD 0.046

REMARK 500 MET E 162 SD MET E 162 CG 0.047

REMARK 500 MET E 189 CE MET E 189 SD 0.050

REMARK 500 MET F 218 CE MET F 218 SD -0.073

REMARK 500 PRO F 286 CD PRO F 286 CG 0.048

REMARK 500 PRO G 361 CG PRO G 361 CB 0.061

REMARK 500 PRO G 363 CG PRO G 363 CB 0.051

REMARK 500 PRO H 363 CG PRO H 363 CB 0.048

REMARK 500

REMARK 500 GEOMETRY AND STEREOCHEMISTRY

REMARK 500 SUBTOPIC: COVALENT BOND ANGLES

REMARK 500

REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES

REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE

REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN

REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).

REMARK 500

REMARK 500 STANDARD TABLE: Table 3

REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)

REMARK 500

REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991

REMARK 500

REMARK 500 M RES CSSEQI ATM 1 ATM2 ATM3

REMARK 500 ARG A 22 N CA - C ANGL. DEV. =-10.0 DEGREES REMARK 500 SER A 64 N - CA C ANGL. DEV. = -9.7 DEGREES REMARK 500 THR A 112 N - CA - C ANGL. DEV. = 10.5 DEGREES REMARK 500 VAL A 116 N - CA - C ANGL. DEV. =-10.5 DEGREES REMARK 500 ARG B 22 N CA C ANGL. DEV. =-10.2 DEGREES REMARK 500 SER B 64 N - CA C ANGL. DEV. = -9.9 DEGREES REMARK 500 THR B 112 N CA C ANGL. DEV. = 10.8 DEGREES REMARK 500 VAL B 116 N - CA C ANGL. DEV. =-10.1 DEGREES REMARK 500 ARG C 22 N CA C ANGL. DEV. = -9.5 DEGREES REMARK 500 SER C 64 N - CA C ANGL. DEV. = -9.0 DEGREES REMARK 500 THR C 112 N - CA - C ANGL. DEV. = 10.7 DEGREES REMARK 500 VAL C 116 N - CA - C ANGL. DEV. = -9.8 DEGREES REMARK 500 ARG D 22 N CA C ANGL. DEV. = -9.6 DEGREES REMARK 500 SER D 64 N • CA C ANGL. DEV. = -9.2 DEGREES REMARK 500 THR D 112 N - CA - C ANGL. DEV. = 10.6 DEGREES REMARK 500 VAL D 116 N - CA - C ANGL. DEV. = 10.1 DEGREES REMARK 500 GLU E 234 N - CA - C ANGL. DEV. = 8.0 DEGREES REMARK 500 CYS E 342 N CA C ANGL. DEV. = -8.2 DEGREES REMARK 500 GLU F 234 N - CA - C ANGL. DEV. = 8.2 DEGREES REMARK 500 LEU F 258 CA - CB - CG ANGL. DEV. = 8.1 DEGREES REMARK 500 CYS F 342 N CA C ANGL. DEV. = -8.5 DEGREES REMARK 500 GLU G 234 N - CA - C ANGL. DEV. = 8.6 DEGREES REMARK 500 ALA G 362 N - CA - C ANGL. DEV. = 13.7 DEGREES REMARK 500 PRO G 363 C ^■ N ^■ CA ANGL. DEV. =-10.5 DEGREES REMARK 500 GLU H 234 N - CA - C ANGL. DEV. = 8.6 DEGREES

REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: 1CVS RELATED DB: PDB REMARK 900 CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR REMARK 900 LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFRl) REMARK 900 RELATED ID: 1EVT RELATED DB: PDB REMARK 900 FGF1-FGFR1 COMPLEX

DBREF 1EV2 A 15 146 SWS P P0099003388 FGF2_HUMAN 24 155 DBREF 1EV2 B 15 146 SWS PP0099003388 FGF2_HUMAN 24 155 DBREF 1EV2 C 15 146 SWS PP0099003388 FGF2_HUMAN 24 155 DBREF 1EV2 D 15 146 SWS PP0099003388 FGF2 HUMAN 24 155 DBREF 1EV2 E 147 366 SWS PP2211880022 FGR2 HUMAN 147 366 DBREF 1EV2 F 147 366 SWS P21802 FGR2_HUMAN 147 366 DBREF 1EV2 G 147 366 SWS P21802 FGR2JHUMAN 147 366 DBREF 1EV2 H 147 366 SWS P21802 FGR2 HUMAN 147 366 SEQADV 1EV2 SER A 69 SWS P09038 CYS 78 ENGINEERED SEQADV 1EV2 SER A 87 SWS P09038 CYS 96 ENGINEERED SEQADV 1EV2 SER B 69 SWS P09038 CYS 78 ENGINEERED SEQADV 1EV2 SER B 87 SWS P09038 CYS 96 ENGINEERED SEQADV 1EV2 SER C 69 SWS P09038 CYS 78 ENGINEERED SEQADV 1EV2 SER C 87 SWS P09038 CYS 96 ENGINEERED SEQADV 1EV2 SER D 69 SWS P09038 CYS 78 ENGINEERED SEQADV 1EV2 SER D 87 SWS P09038 CYS 96 ENGINEERED SEQRES 1 A 132 GLY HIS PHE LYS ASP PRO LYS ARG LEU TYR CYS LYS ASN SEQRES 2 A 132 GLY GLY PHE PHE LEU ARG ILE HIS PRO ASP GLY ARG VAL TabU 3

SEQRES 3 A 132 ASP GLY VAL ARG GLU LYS SER ASP PRO HIS ILE LYS LEU

SEQRES 4 A 132 GLN LEU GLN ALA GLU GLU ARG GLY VAL VAL SER ILE LYS

SEQRES 5 A 132 GLY VAL SER ALA ASN ARG TYR LEU ALA MET LYS GLU ASP

SEQRES 6 A 132 GLY ARG LEU LEU ALA SER LYS SER VAL THR ASP GLU CYS

SEQRES 7 A 132 PHE PHE PHE GLU ARG LEU GLU SER ASN ASN TYR ASN THR

SEQRES 8 A 132 TYR ARG SER ARG LYS TYR THR SER TRP TYR VAL ALA LEU

SEQRES 9 A 132 LYS ARG THR GLY GLN TYR LYS LEU GLY SER LYS THR GLY

SEQRES 10 A 132 PRO GLY GLN LYS ALA ILE LEU PHE LEU PRO MET SER ALA

SEQRES 11 A 132 LYS SER

SEQRES I B 132 GLY HIS PHE LYS ASP PRO LYS ARG LEU TYR CYS LYS ASN

SEQRES 2 B 132 GLY GLY PHE PHE LEU ARG ILE HIS PRO ASP GLY ARG VAL

SEQRES 3 B 132 ASP GLY VAL ARG GLU LYS SER ASP PRO HIS ILE LYS LEU

SEQRES 4 B 132 GLN LEU GLN ALA GLU GLU ARG GLY VAL VAL SER ILE LYS

SEQRES 5 B 132 GLY VAL SER ALA ASN ARG TYR LEU ALA MET LYS GLU ASP

SEQRES 6 B 132 GLY ARG LEU LEU ALA SER LYS SER VAL THR ASP GLU CYS

SEQRES 7 B 132 PHE PHE PHE GLU ARG LEU GLU SER ASN ASN TYR ASN THR

SEQRES 8 B 132 TYR ARG SER ARG LYS TYR THR SER TRP TYR VAL ALA LEU

SEQRES 9 B 132 LYS ARG THR GLY GLN TYR LYS LEU GLY SER LYS THR GLY

SEQRES 10 B 132 PRO GLY GLN LYS ALA ILE LEU PHE LEU PRO MET SER ALA

SEQRES 11 B 132 LYS SER

SEQRES 1 C 132 GLY HIS PHE LYS ASP PRO LYS ARG LEU TYR CYS LYS ASN

SEQRES 2 C 132 GLY GLY PHE PHE LEU ARG ILE HIS PRO ASP GLY ARG VAL

SEQRES 3 C 132 ASP GLY VAL ARG GLU LYS SER ASP PRO HIS ILE LYS LEU

SEQRES 4 C 132 GLN LEU GLN ALA GLU GLU ARG GLY VAL VAL SER ILE LYS

SEQRES 5 C 132 GLY VAL SER ALA ASN ARG TYR LEU ALA MET LYS GLU ASP

SEQRES 6 C 132 GLY ARG LEU LEU ALA SER LYS SER VAL THR ASP GLU CYS

SEQRES 7 C 132 PHE PHE PHE GLU ARG LEU GLU SER ASN ASN TYR ASN THR

SEQRES 8 C 132 TYR ARG SER ARG LYS TYR THR SER TRP TYR VAL ALA LEU

SEQRES 9 C 132 LYS ARG THR GLY GLN TYR LYS LEU GLY SER LYS THR GLY

SEQRES IO C 132 PRO GLY GLN LYS ALA ILE LEU PHE LEU PRO MET SER ALA

SEQRES 11 C 132 LYS SER

SEQRES I D 132 GLY HIS PHE LYS ASP PRO LYS ARG LEU TYR CYS LYS ASN

SEQRES 2 D 132 GLY GLY PHE PHE LEU ARG ILE HIS PRO ASP GLY ARG VAL

SEQRES 3 D 132 ASP GLY VAL ARG GLU LYS SER ASP PRO HIS ILE LYS LEU

SEQRES 4 D 132 GLN LEU GLN ALA GLU GLU ARG GLY VAL VAL SER ILE LYS

SEQRES 5 D 132 GLY VAL SER ALA ASN ARG TYR LEU ALA MET LYS GLU ASP

SEQRES 6 D 132 GLY ARG LEU LEU ALA SER LYS SER VAL THR ASP GLU CYS

SEQRES 7 D 132 PHE PHE PHE GLU ARG LEU GLU SER ASN ASN TYR ASN THR

SEQRES 8 D 132 TYR ARG SER ARG LYS TYR THR SER TRP TYR VAL ALA LEU

SEQRES 9 D 132 LYS ARG THR GLY GLN TYR LYS LEU GLY SER LYS THR GLY

SEQRES 10 D 132 PRO GLY GLN LYS ALA ILE LEU PHE LEU PRO MET SER ALA

SEQRES 11 D 132 LYS SER

SEQRES 1 E 220 ASN SER ASN ASN LYS ARG ALA PRO TYR TRP THR ASN THR

SEQRES 2 E 220 GLU LYS MET GLU LYS ARG LEU HIS ALA VAL PRO ALA ALA

SEQRES 3 E 220 ASN THR VAL LYS PHE ARG CYS PRO ALA GLY GLY ASN PRO

SEQRES 4 E 220 MET PRO THR MET ARG TRP LEU LYS ASN GLY LYS GLU PHE

SEQRES 5 E 220 LYS GLN GLU HIS ARG ILE GLY GLY TYR LYS VAL ARG ASN

SEQRES 6 E 220 GLN HIS TRP SER LEU ILE MET GLU SER VAL VAL PRO SER

SEQRES 7 E 220 ASP LYS GLY ASN TYR THR CYS VAL VAL GLU ASN GLU TYR

SEQRES 8 E 220 GLY SER ILE ASN HIS THR TYR HIS LEU ASP VAL VAL GLU

SEQRES 9 E 220 ARG SER PRO HIS ARG PRO ILE LEU GLN ALA GLY LEU PRO

SEQRES 10 E 220 ALA ASN ALA SER THR VAL VAL GLY GLY ASP VAL GLU PHE

SEQRES H E 220 VAL CYS LYS VAL TYR SER ASP ALA GLN PRO HIS ILE GLN

SEQRES 12 E 220 TRP ILE LYS HIS VAL GLU LYS ASN GLY SER LYS TYR GLY

SEQRES 13 E 220 PRO ASP GLY LEU PRO TYR LEU LYS VAL LEU LYS ALA ALA Table 3

SEQRES 14 E 220 GLY VAL ASN THR THR ASP LYS GLU ILE GLU VAL LEU TYR

SEQRES 15 E 220 ILE ARG ASN VAL THR PHE GLU ASP ALA GLY GLU TYR THR

SEQRES 16 E 220 CYS LEU ALA GLY ASN SER ILE GLY ILE SER PHE HIS SER

SEQRES 17 E 220 ALA TRP LEU THR VAL LEU PRO ALA PRO GLY ARG GLU

SEQRES I F 220 ASN SER ASN ASN LYS ARG ALA PRO TYR TRP THR ASN THR

SEQRES 2 F 220 GLU LYS MET GLU LYS ARG LEU HIS ALA VAL PRO ALA ALA

SEQRES 3 F 220 ASN THR VAL LYS PHE ARG CYS PRO ALA GLY GLY ASN PRO

SEQRES 4 F 220 MET PRO THR MET ARG TRP LEU LYS ASN GLY LYS GLU PHE

SEQRES 5 F 220 LYS GLN GLU HIS ARG ILE GLY GLY TYR LYS VAL ARG ASN

SEQRES 6 F 220 GLN HIS TRP SER LEU ILE MET GLU SER VAL VAL PRO SER

SEQRES 7 F 220 ASP LYS GLY ASN TYR THR CYS VAL VAL GLU ASN GLU TYR

SEQRES 8 F 220 GLY SER ILE ASN HIS THR TYR HIS LEU ASP VAL VAL GLU

SEQRES 9 F 220 ARG SER PRO HIS ARG PRO ILE LEU GLN ALA GLY LEU PRO

SEQRES 10 F 220 ALA ASN ALA SER THR VAL VAL GLY GLY ASP VAL GLU PHE

SEQRES 11 F 220 VAL CYS LYS VAL TYR SER ASP ALA GLN PRO HIS ILE GLN

SEQRES 12 F 220 TRP ILE LYS HIS VAL GLU LYS ASN GLY SER LYS TYR GLY

SEQRES 13 F 220 PRO ASP GLY LEU PRO TYR LEU LYS VAL LEU LYS ALA ALA

SEQRES 14 F 220 GLY VAL ASN THR THR ASP LYS GLU ILE GLU VAL LEU TYR

SEQRES 15 F 220 ILE ARG ASN VAL THR PHE GLU ASP ALA GLY GLU TYR THR

SEQRES 16 F 220 CYS LEU ALA GLY ASN SER ILE GLY ILE SER PHE HIS SER

SEQRES 17 F 220 ALA TRP LEU THR VAL LEU PRO ALA PRO GLY ARG GLU

SEQRES I G 220 ASN SER ASN ASN LYS ARG ALA PRO TYR TRP THR ASN THR

SEQRES 2 G 220 GLU LYS MET GLU LYS ARG LEU HIS ALA VAL PRO ALA ALA

SEQRES 3 G 220 ASN THR VAL LYS PHE ARG CYS PRO ALA GLY GLY ASN PRO

SEQRES 4 G 220 MET PRO THR MET ARG TRP LEU LYS ASN GLY LYS GLU PHE

SEQRES 5 G 220 LYS GLN GLU HIS ARG ILE GLY GLY TYR LYS VAL ARG ASN

SEQRES 6 G 220 GLN HIS TRP SER LEU ILE MET GLU SER VAL VAL PRO SER

SEQRES 7 G 220 ASP LYS GLY ASN TYR THR CYS VAL VAL GLU ASN GLU TYR

SEQRES 8 G 220 GLY SER ILE ASN HIS THR TYR HIS LEU ASP VAL VAL GLU

SEQRES 9 G 220 ARG SER PRO HIS ARG PRO ILE LEU GLN ALA GLY LEU PRO

SEQRES 10 G 220 ALA ASN ALA SER THR VAL VAL GLY GLY ASP VAL GLU PHE

SEQRES 11 G 220 VAL CYS LYS VAL TYR SER ASP ALA GLN PRO HIS ILE GLN

SEQRES 12 G 220 TRP ILE LYS HIS VAL GLU LYS ASN GLY SER LYS TYR GLY

SEQRES 13 G 220 PRO ASP GLY LEU PRO TYR LEU LYS VAL LEU LYS ALA ALA

SEQRES 14 G 220 GLY VAL ASN THR THR ASP LYS GLU ILE GLU VAL LEU TYR

SEQRES 15 G 220 ILE ARG ASN VAL THR PHE GLU ASP ALA GLY GLU TYR THR

SEQRES 16 G 220 CYS LEU ALA GLY ASN SER ILE GLY ILE SER PHE HIS SER

SEQRES 17 G 220 ALA TRP LEU THR VAL LEU PRO ALA PRO GLY ARG GLU

SEQRES I H 220 ASN SER ASN ASN LYS ARG ALA PRO TYR TRP THR ASN THR

SEQRES 2 H 220 GLU LYS MET GLU LYS ARG LEU HIS ALA VAL PRO ALA ALA

SEQRES 3 H 220 ASN THR VAL LYS PHE ARG CYS PRO ALA GLY GLY ASN PRO

SEQRES 4 H 220 MET PRO THR MET ARG TRP LEU LYS ASN GLY LYS GLU PHE

SEQRES 5 H 220 LYS GLN GLU HIS ARG ILE GLY GLY TYR LYS VAL ARG ASN

SEQRES 6 H 220 GLN HIS TRP SER LEU ILE MET GLU SER VAL VAL PRO SER

SEQRES 7 H 220 ASP LYS GLY ASN TYR THR CYS VAL VAL GLU ASN GLU TYR

SEQRES 8 H 220 GLY SER ILE ASN HIS THR TYR HIS LEU ASP VAL VAL GLU

SEQRES 9 H 220 ARG SER PRO HIS ARG PRO ILE LEU GLN ALA GLY LEU PRO

SEQRES 10 H 220 ALA ASN ALA SER THR VAL VAL GLY GLY ASP VAL GLU PHE

SEQRES 11 H 220 VAL CYS LYS VAL TYR SER ASP ALA GLN PRO HIS ILE GLN

SEQRES 12 H 220 TRP ILE LYS HIS VAL GLU LYS ASN GLY SER LYS TYR GLY

SEQRES 13 H 220 PRO ASP GLY LEU PRO TYR LEU LYS VAL LEU LYS ALA ALA

SEQRES 14 H 220 GLY VAL ASN THR THR ASP LYS GLU ILE GLU VAL LEU TYR

SEQRES 15 H 220 ILE ARG ASN VAL THR PHE GLU ASP ALA GLY GLU TYR THR

SEQRES 16 H 220 CYS LEU ALA GLY ASN SER ILE GLY ILE SER PHE HIS SER

SEQRES 17 H 220 ALA TRP LEU THR VAL LEU PRO ALA PRO GLY ARG GLU Table 3

HET S04 9001 5 HET S04 9002 5 HET S04 9003 5 HET S04 9004 5

HETNAM S04 SULFATE ION FORMUL 9 S04 4(04 SI 2-) FORMUL 13 HOH *263(H201)

HELIX 1 1 LEU A 126 THR A 1305 5

HELDC 2 2LEUB 126 THRB 1305 5

HELIX 3 3 LEU C 126 THR C 1305 5

HELIX 4 4 LEU D 126 THR D 1305 5

HELIX 5 5 ASNE 158 GLUE 1635 6

HELIX 6 6 LYS E 199 ARG E 2035 5

HELIX 7 7 ASNE 211 HIS E 2135 3

HELIX 8 8 VAL E 222 LYS E 2265 5

HELIX 9 9 THR E 333 ALA E 3375 5

HELIX 10 10 ASNF 158 GLUF 1635 6

HELIX 11 11 LYSF 199 ARG F 2035 5

HELIX 12 12 ASN F 211 HIS F 2135 3

HELIX 13 13 VAL F 222 LYS F 2265 5

HELIX 14 14 THR F 333 ALA F 3375 5

HELIX 15 15 ASNG 158 GLUG 1635 6

HELIX 16 16 LYSG 199 ARG G 2035 5

HELIX 17 17 ASNG 211 HIS G 2135 3

HELD. 18 18 VAL G 222 LYS G 2265 5

HELIX 19 19 THR G 333 ALA G 3375 5

HELIX 2020 ASNH 158 GLUH 1635 6

HELIX 21 21 LYS H 199 ARG H 2035 5

HELIX 2222 ASNH 211 HIS H 2135 3

HELDC 23 23 VAL H 222 LYS H 2265 5

HELDC 2424 THR H 333 ALA H 3375 5

SHEET 1 A 4 VAL A 40 VAL A 430

SHEET 2 A 4 PHE A 30 ILE A 34 -1 N PHE A 31 O VAL A 43 SHEET 3 A 4 LYS A 21 CYS A 25 -1 O LEU A 23 N LEU A 32 SHEET 4 A 4 PHE A 139 SER A 143 -1 N LEU A 140 O TYR A 24 SHEET 1 B 4 LEU A 53 GLU A 590

SHEET 2 B 4 VAL A 62 GLY A 67-1 N VAL A 62 O GLU A 59 SHEET 3 B 4 ARG A 72 MET A 76-1 O ARG A 72 N GLY A 67 SHEET 4 B 4 LEU A 82 SER A 85 -1 O LEU A 83 N ALA A 75 SHEET 1 C 4 LEU A 53 GLU A 590

SHEET 2 C 4 VAL A 62 GLY A 67 -1 N VAL A 62 O GLU A 59 SHEET 3 C 4 PHE A 94 LEU A 98-1 N PHE A 94 O VAL A 63 SHEET 4 C 4 ASN A 104 SER A 108 -1 O THR A 105 N ARG A 97 SHEET 1 D 4 VAL B 40 VAL B 430

SHEET 2 D 4 PHE B 30 ILE B 34 -1 N PHE B 31 O VAL B 43 SHEET 3 D 4 LYS B 21 CYS B 25 -1 O LEU B 23 N LEU B 32 SHEET 4 D 4 PHE B 139 SER B 143 -1 N LEU B 140 O TYR B 24 SHEET 1 E 4 LEU B 53 GLU B 590

SHEET 2 E4VALB 62 GLY B 67-1 N VALB 62 O GLUB 59 SHEET 3 E4ARGB 72 MET B 76-1 O ARGB 72 N GLY B 67 SHEET 4 E 4 LEU B 82 SER B 85 -1 O LEU B 83 N ALA B 75 SHEET 1 F 4 LEU B 53 GLU B 590

SHEET 2 F 4 VALB 62 GLY B 67-1 N VALB 62 O GLUB 59 SHEET 3 F4PHEB 94 LEU B 98-1 N PHE B 94 O VALB 63 SHEET 4 F 4 ASN B 104 SER B 108 -1 O THR B 105 N ARG B 97 Table 3

SHEET 1 G4VALC 40 VAL C 43 0

SHEET 2 G4PHEC 30 ILE C 34-1 N PHE C 31 O VALC 43

SHEET 3 G 4 LYS C 21 CYS C 25 -1 O LEU C 23 N LEU C 32

SHEET 4 G 4 PHE C 139 SER C 143 -1 N LEU C 140 O TYR C 24

SHEET 1 H4LEUC 53 GLU C 590

SHEET 2 H 4 VALC 62 GLY C 67-1 N VALC 62 O GLU C 59

SHEET 3 H4ARGC 72 MET C 76-1 O ARG C 72 N GLY C 67

SHEET 4 H4LEUC 82 SER C 85-1 O LEU C 83 N ALA C 75

SHEET 1 I 4 LEU C 53 GLU C 590

SHEET 2 14 VALC 62 GLY C 67-1 N VALC 62 O GLU C 59

SHEET 3 I 4 PHE C 94 LEU C 98-1 O PHE C 94 N VALC 63

SHEET 4 14 ASN C 104 SER C 108 -1 O THR C 105 N ARG C 97

SHEET 1 J4VALD 40 VAL D 43 0

SHEET 2 J4PHED 30 ILE D 34-1 N PHE D 31 O VALD 43

SHEET 3 J4LYSD 21 CYS D 25-1 O LEU D 23 N LEU D 32

SHEET 4 J 4 PHE D 139 SER D 143 -1 N LEU D 140 O TYR D 24

SHEET 1 K 4 LEU D 53 GLU D 590

SHEET 2 K 4 VALD 62 GLY D 67-1 N VALD 62 O GLU D 59

SHEET 3 K4ARGD 72 MET D 76-1 O ARG D 72 N GLY D 67

SHEET 4 K4LEUD 82 SERD 85-1 O LEU D 83 N ALA D 75

SHEET 1 L 4 LEU D 53 GLU D 590

SHEET 2 L 4 VALD 62 GLY D 67-1 N VALD 62 O GLU D 59

SHEET 3 L4PHED 94 LEU D 98-1 O PHE D 94 N VALD 63

SHEET 4 L 4 ASN D 104 SER D 108 -1 O THR D 105 N ARG D 97

SHEET 1 M 2 ARG E 152 TRP E 1560

SHEET 2 M 2 ALA E 181 ASN E 184 -1 N GLY E 182 O TYR E 155

SHEET 1 N 5 LEU E 166 PRO E 1700

SHEET 2 N 5 GLY E 238 VAL E 249 1 O HIS E 245 N HIS E 167

SHEET 3 N 5 GLYE 227 ASNE 235-1 O GLYE 227 N LEU E 246

SHEET 4 N 5 THR E 188 LYS E 193 -1 N THR E 188 O GLU E 234

SHEET 5 N 5 LYS E 196 GLU E 197 -1 O LYS E 196 N LYS E 193

SHEET 1 O 3 VAL E 175 ARG E 178 0

SHEET 2 O 3 SER E 215 MET E 218 -1 O LEU E 216 N PHE E 177

SHEET 3 O 3 LYS E 208 ARG E 210 -1 O LYS E 208 N ILE E 217

SHEET 1 P 2 ILE E 257 LEU E 2580

SHEET 2 P 2 VAL E 280 TYR E 281 -1 O TYR E 281 N ILE E 257

SHEET 1 Q 2 VALE 274 VALE 277 0

SHEET 2 Q 2 VALE 326 ILE E 329-1 N LEU E 327 O PHE E 276

SHEET 1 R 4 LEU E 309 ALA E 3140

SHEET 2 R 4 HIS E 287 HIS E 293 -1 N TRP E 290 O LYSE 313

SHEET 3 R 4 GLY E 338 GLY E 345 -1 O GLU E 339 N HIS E 293

SHEET 4 R 4 ILE E 350 LEU E 357 -1 O SERE 351 N ALA E 344

SHEET 1 S 2 ARG F 152 TRP F 1560

SHEET 2 S 2 ALA F 181 ASN F 184 -1 N GLY F 182 O TYR F 155

SHEET 1 T 5 LEU F 166 PRO F 1700

SHEET 2 T 5 GLY F 238 VAL F 249 1 O HIS F 245 N HIS F 167

SHEET 3 T 5 GLYF 227 ASN F 235 -1 O GLYF 227 N LEU F 246

SHEET 4 T 5 THR F 188 LYS F 193 -1 N THR F 188 O GLU F 234

SHEET 5 T 5 LYS F 196 GLU F 197 -1 O LYS F 196 N LYS F 193

SHEET 1 U 3 VAL F 175 ARG F 1780

SHEET 2 U 3 SER F 215 MET F 218 -1 O LEU F 216 N PHE F 177

SHEET 3 U 3 LYSF 208 ARG F 210-1 O LYS F 208 N ILE F 217

SHEET 1 V 2 ILE F 257 LEU F 2580

SHEET 2 V 2 VAL F 280 TYR F 281 -1 O TYR F 281 N ILE F 257

SHEET 1 W 5 ALA F 266 SERF 2670 Table 3 SHEET 2 W 5 ILE F 350 THR F 358 1 O TRP F 356 N ALA F 266

SHEET 3 W 5 GLY F 338 GLY F 345 -1 O GLY F 338 N LEU F 357

SHEET 4 W 5 HIS F 287 LYS F 292 -1 N HIS F 287 O GLY F 345

SHEET 5 W 5 LYS F 310 ALA F 314 -1 O LYS F 310 N LYS F 292

SHEET 1 X 2 VAL F 274 VAL F 277 0

SHEET 2 X2 VAL F 326 ILE F 329 -1 N LEU F 327 O PHE F 276

SHEET 1 Y 2 ARG G 152 TRP G 1560

SHEET 2 Y 2 ALA G 181 ASN G 184 -1 N GLY G 182 O TYR G 155

SHEET 1 Z 5 LEU G 166 PRO G 1700

SHEET 2 Z 5 GLY G 238 VAL G 249 1 O HIS G 245 N HIS G 167

SHEET 3 Z 5 GLYG 227 ASN G 235 -1 O GLYG 227 N LEU G 246

SHEET 4 Z 5 THR G 188 LYS G 193 -1 N THR G 188 O GLU G 234

SHEET 5 Z 5 LYS G 196 GLU G 197 -1 O LYS G 196 N LYS G 193

SHEET 1 AA 3 VAL G 175 ARG G 1780

SHEET 2 AA 3 SER G 215 MET G 218 -1 O LEU G 216 N PHE G 177

SHEET 3 AA 3 LYS G 208 ARG G 210 -1 O LYS G 208 N ILE G 217

SHEET 1 AB2ILEG257 LEU G 2580

SHEET 2 AB 2 VAL G 280 TYR G 281 -1 O TYR G 281 N ILE G 257

SHEET 1 AC 5 ALA G 266 VAL G 2690

SHEET 2 AC 5 ILE G 350 LEU G 360 1 O TRP G 356 N ALA G 266

SHEET 3 AC 5 GLYG 338 GLYG 345-1 O GLYG 338 N LEU G 357

SHEET 4 AC 5 HIS G 287 HIS G 293-1 N HIS G 287 O GLY G 345

SHEET 5 AC 5 LEU G 309 ALA G 314-1 O LYSG 310 N LYS G 292

SHEET 1 AD 2 VAL G 274 VAL G 2770

SHEET 2 AD 2 VAL G 326 ILE G 329 -1 N LEU G 327 O PHE G 276

SHEET 1 AE 2 ARG H 152 TRP H 1560

SHEET 2 AE 2 ALA H 181 ASN H 184 -1 N GLY H 182 O TYR H 155

SHEET 1 AF 5 LEU H 166 PRO H 1700

SHEET 2 AF 5 GLY H 238 VAL H 249 1 O HIS H 245 N HIS H 167

SHEET 3 AF 5 GLYH 227 ASN H 235 -1 O GLY H 227 N LEU H 246

SHEET 4 AF 5 THR H 188 LYS H 193 -1 N THR H 188 O GLU H 234

SHEET 5 AF 5 LYS H 196 GLU H 197 -1 O LYS H 196 N LYS H 193

SHEET 1 AG 3 VAL H 175 ARG H 1780

SHEET 2 AG 3 SER H 215 MET H 218 -1 O LEU H 216 N PHE H 177

SHEET 3 AG 3 LYS H 208 ARG H 210 -1 O LYS H 208 N ILE H 217

SHEET 1 AH 2 ILE H 257 LEU H 2580

SHEET 2 AH 2 VAL H 280 TYR H 281 -1 O TYR H 281 N ILE H 257

SHEET 1 AI5ALAH266 VAL H 2690

SHEET 2 AI5ILEH350 LEU H 360 1 O TRP H 356 N ALA H 266

SHEET 3 Al 5 GLYH 338 GLY H 345 -1 O GLY H 338 N LEU H 357

SHEET 4 Al 5 HIS H 287 HIS H 293 -1 N HIS H 287 O GLY H 345

SHEET 5 Al 5 LEU H 309 ALA H 314 -1 O LYS H 310 N LYS H 292

SHEET 1 AJ2VALH274 VAL H 2770

SHEET 2 AJ2VALH326 ILE H 329-1 N LEU H 327 O PHE H 276

SSBOND 1 CYS E 179 CYS E 231

SSBOND 2 CYS E 278 CYS E 342

SSBOND 3CYSF 179 CYS F 231

SSBOND 4CYSF 278 CYS F 342

SSBOND 5 CYS G 179 CYS G 231

SSBOND 6CYSG 278 CYS G 342

SSBOND 7 CYS H 179 CYS H 231

SSBOND 8CYSH 278 CYS H 342

CISPEP 1ASNE 184 PROE 185 0 0.40

CISPEP 2 LEU E 262 PRO E 263 0 -0.38

CISPEP 3 ASNF 184 PROF 185 0 0.15 Table3

CISPEP 4 LEUF 262 PROF 263 0 -0.12

CISPEP 5 ASNG 184 PROG 185 0 0.49

CISPEP 6LEUG 262 PROG 263 0 -0.21

CISPEP 7 ASNH 184 PROH 185 0 0.32

CISPEP 8LEUH 262 PROH 263 0 0.10

CRYST1 72.198 ' 71.677 90.92090.53 89.98 89.99 P 1 4

ORIGX1 1.0000000.0000000.000000 0.00000

ORIGX2 0.000000 1.0000000.000000 0.00000

ORIGX3 0.0000000.000000 1.000000 0.00000

SCALE1 0.013851 -0.000002 -0.000005 0.00000

SCALE2 0.000000 0.013951 0.000129 0.00000

SCALE3 0.0000000.0000000.010999 0.00000

ATOM 1 N HIS A 16 65.781 -6.823 6.422 1.00 40.96 N

ATOM 2 CA HIS A 16 66.617 -7.615 7.378 1.00 40.54 C

ATOM 3 C HIS A 16 68.092 -7.469 7.011 1.00 39.31 C

ATOM 4 o HIS A 16 68.508 -7.845 5.917 1.00 39.03 o

ATOM 5 CB HIS A 16 66.208 -9.095 7.337 1.00 41.05 c

ATOM 6 N PHE A 17 68.872 -6.932 7.942 1.00 38.01 N

ATOM 7 CA PHE A 17 70.295 -6.694 7.734 1.00 37.01 c

ATOM 8 C PHE A 17 71.138 -7.925 7.375 1.00 36.59 c

ATOM 9 o PHE A 17 72.148 -7.797 6.674 1.00 35.98 o

ATOM 10 CB PHE A 17 70.876 -6.008 8.975 1.00 35.65 c

ATOM 11 CG PHE A 17 70.934 -6.887 10.184 1.00 35.24 c

ATOM 12 CDl PHE A 17 72.061 -7.659 10.442 1.00 35.09 c

ATOM 13 CD2 PHE A 17 69.877 -6.928 11.084 1.00 35.37 c

ATOM 14 CEl PHE A 17 72.139 -8.452 11.578 1.00 35.43 c

ATOM 15 CE2 PHE A 17 69.942 -7.724 12.231 1.00 35.92 c

ATOM 16 CZ PHE A 17 71.075 -8.487 12.479 1.00 35.61 c

ATOM 17 N LYS A 18 70.743 -9.106 7.844 1.00 36.25 N TOM 18 CA LYS A 18 71.527 -10.296 7.529 1.00 37.09 C

ATOM 19 C LYS A 18 71.279 -10.894 6.143 1.00 37.63 c

ATOM 20 o LYS A 18 72.035 -11.753 5.690 1.00 38.05 o

ATOM 21 CB LYS A 18 71.410 -11.364 8.626 1.00 37.68 c

ATOM 22 CG LYS A 18 70.092 -11.449 9.358 1.00 40.55 c

ATOM 23 CD LYS A 18 70.220 -12.396 10.551 1.00 41.58 c

ATOM 24 CE LYS A 18 68.877 -12.603 11.238 1.00 42.51 c

ATOM 25 ^•NZ LYS A 18 68.252 -11.308 11.616 1.00 43.74 N

ATOM 26 N ASP A 19 70.251 -10.412 5.453 1.00 37.64 N

ATOM 27 CA ASP A 19 69.948 -10.882 4.106 1.00 37.79 c

ATOM 28 C ASP A 19 70.899 -10.289 3.067 1.00 37.96 c

ATOM 29 o ASP A 19 71.364 -9.150 3.206 1.00 37.12 o

ATOM 30 CB ASP A 19 68.532 -10.476 3.701 1.00 39.51 C

ATOM 31 CG ASP A 19 67.454 -11.162 4.521 1.00 40.50 c

ATOM 32 ODl ASP A 19 66.291 -10.708 4.445 1.00 40.65 o

ATOM 33 OD2 ASP A 19 67.760 -12.152 5.220 1.00 41.75 o

ATOM 34 N PRO A 20 71.209 -11.066 2.011 1.00 38.07 N

ATOM 35 CA PRO A 20 72.092 -10.620 0.929 1.00 37.64 c

ATOM 36 C PRO A 20 71.431 -9.441 0.211 1.00 37.31 C

ATOM 37 0 PRO A 20 70.217 -9.264 0.300 1.00 36.68 o

ATOM 38 CB PRO A 20 72.208 -11.860 0.033 1.00 38.78 C

ATOM 39 CG PRO A 20 70.966 -12.663 0.352 1.00 39.38 C

ATOM 40 CD PRO A 20 70.850 -12.489 1.845 1.00 38.63 C

ATOM 41 N LYS A 21 72.218 -8.648 -0.508 1.00 36.88 N

ATOM 42 CA LYS A 21 71.676 -7.467 -1.180 1.00 37.48 C

ATOM 43 C LYS A 21 72.379 -7.166 -2.476 1.00 37.29 C

ATOM 44 o LYS A 21 73.460 -7.684 -2.752 1.00 37.08 o

ATOM 45 CB LYS A 21 71.872 -6.198 -0.336 1.00 37.95 C

ATOM 46 CG LYS A 21 71.512 -6.244 1.129 1.00 38.66 C

ATOM 47 CD LYS A 21 71.931 -4.921 1.755 1.00 40.44 C

ATOM 48 CE LYS A 21 71.606 -4.821 3.239 1.00 42.18 C

ATOM 49 NZ LYS A 21 71.769 -3.412 3.691 1.00 42.97 N

ATOM 50 N ARG A 22 71.761 -6.288 -3.254 1.00 36.67 N

ATOM 51 CA ARG A 22 72.355 -5.825 -4.492 1.00 36.55 C Table 3

ATOM 52 C ARG A 22 72.707 -4.390 -4, ,132 1, ,00 35. ,63 c

ATOM 53 o ARG A 22 71.986 -3.755 -3, ,360 1, ,00 36. .38 o

ATOM 54 CB ARG A 22 71.340 -5.813 -5. ,633 1. ,00 38. ,00 c

ATOM 55 CG ARG A 22 70.630 -7.118 -5, ,891 1, ,00 40, .54 c

ATOM 56 CD ARG A 22 69.712 -6.938 -7, .092 1, .00 43, .45 c

ATOM 57 NE ARG A 22 68.439 -7.649 -6. .962 1, .00 47, .18 N

ATOM 58 CZ ARG A 22 68.163 -8.822 -7, .524 1, ,00 48. .01 C

ATOM 59 NHl ARG A 22 69.072 -9.436 -8, .267 1, ,00 50. .26 N

ATOM 60 NH2 ARG A 22 66.971 -9.381 -7, .348 1. .00 48. .58 N

ATOM 61 N LEU A 23 73.818 -3.881 -4, .647 1, .00 34. .34 N

ATOM 62 CA LEU A 23 74.201 -2.502 -4, ,380 1. .00 32, .35 C

ATOM 63 C LEU A 23 74.093 -1.739 -5, .696 1, .00 32, .62 C

Table 3

ATOM 64 o LEU A 23 74, .914 -1. .906 -6. ,603 1. ,00 32. ,26 o

ATOM 65 CB LEU A 23 75, .617 -2, ,419 -3. .811 1. .00 30. ,80 c

ATOM 66 CG LEU A 23 75, .763 -2, .709 -2, .306 1. .00 30. ,93 c

ATOM 67 CDl LEU A 23 77, .234 -2. .691 -1. ,923 1. .00 30. ,37 c

ATOM 68 CD2 LEU A 23 75 .009 -1. .662 -1. .491 1. .00 29. .15 c

ATOM 69 N TYR A 24 73, .051 -0, ,910 -5. .783 1. ,00 31. .86 N

ATOM 70 CA TYR A 24 72, .740 -0, .103 -6, ,965 1. ,00 31. .06 C

ATOM 71 C TYR A 24 73, .479 1, ,236 -6. ,959 1. .00 31. .28 C

ATOM 72 o TYR A 24 73, .373 2, .008 -6, .011 1. ,00 31. .13 0

ATOM 73 CB TYR A 24 71, .207 0, .107 -7, ,032 1. ,00 30. ,62 C

ATOM 74 CG TYR A 24 70, .689 1. ,069 -8, ,092 1. ,00 29, ,13 c

ATOM 75 CDl TYR A 24 70. .769 2, ,450 -7, ,906 1. ,00 29. ,62 c

ATOM 76 CD2 TYR A 24 70, .099 0, ,599 -9, .268 1. ,00 29. ,08 c

ATOM 77 CEl TYR A 24 70, .271 3, .346 -8. ,864 1, ,00 29. ,47 c

ATOM 78 CE2 TYR A 24 69. .598 1, .484 -10, ,236 1, .00 29, ,62 c

ATOM 79 CZ TYR A 24 69, .686 2, .859 -10, ,024 1, ,00 30, .70 c

ATOM 80 OH TYR A 24 69. .181 3. .748 -10. ,957 1, ,00 31. ,61 o

ATOM 81 N CYS A 25 74. .236 1, .510 -8. .020 1. .00 31, .62 N

ATOM 82 CA CYS A 25 74. .975 2. .767 -8, .097 1, .00 32, .94 C

ATOM 83 C CYS A 25 74. .147 3, .842 -8. ,798 1. ,00 33, .32 c

ATOM 84 o CYS A 25 73, .684 3, .650 -9. .921 1, .00 33. .93 o

ATOM 85 CB CYS A 25 76. .311 2. .581 -8. ,836 1, .00 32, ,09 c

ATOM 86 SG CYS A 25 77, ,380 4. ,066 -8. ,811 1. .00 34, .82 S

ATOM 87 N LYS A 26 73, ,963 4. ,970 -8. ,122 I; ;oo 34, .61 N

ATOM 88 CA LYS A 26 73, ,189 6, ,072 -8, .676 1. .00 36, .27 C

ATOM 89 C LYS A 26 73, .786 6. .512 -10, .018 1, .00 37, .44 C

ATOM 90 o LYS A 26 73, .061 6, .928 -10. .923 1. .00 37, .35 O

ATOM 91 CB LYS A 26 73. .171 7. .248 -7, .697 1. .00 36. .24 C TOM 92 CG LYS A 26 72. .293 8, .403 -8. .145 1. .00 38. .36 C

ATOM 93 CD LYS A 26 72. ,480 9. ,630 -7. .270 1. .00 39. .80 c

ATOM 94 CE LYS A 26 71. .585 10, .769 -7. .747 1. .00 41. .47 c

ATOM 95 NZ LYS A 26 71, .853 12. .023 -6. .987 1. .00 42. .04 N

ATOM 96 N ASN A 27 75. ,107 6. ,406 -10. ,148 1, ,00 37. .91 N

ATOM 97 CA ASN A 27 75, ,782 6. ,790 -11. ,386 1, .00 38. .44 C

ATOM 98 C ASN A 27 75, ,509 5, .753 -12. ,479 1, .00 38. ,53 C

ATOM 99 o ASN A 27 76, ,092 4, ,663 -12, ,479 1, .00 38. ,51 0

ATOM 100 CB ASN A 27 77, ,287 6. ,904 -11, .152 1, .00 40. .85 C

ATOM 101 CG ASN A 27 78, .001 7, ,640 -12, .276 1, .00 44. .71 C

ATOM 102 ODl ASN A 27 79, ,237 7. ,582 -12, ,395 1. .00 44. ,59 O

ATOM 103 ND2 ASN A 27 77, ,230 8. ,350 -13, .101 1, .00 44. .65 N

ATOM 104 N GLY A 28 74, .606 6, ,081 -13, .397 1, .00 37, .85 N

ATOM 105 CA GLY A 28 74, .285 5, ,170 -14, ,481 1. .00 37, .25 C

ATOM 106 C GLY A 28 73. .303 4. ,054 -14. .159 1, .00 37, .29 C

ATOM 107 o GLY A 28 72, .750 3, .427 -15. .065 1, .00 37, .26 O

ATOM 108 N GLY A 29 73. ,089 3. ,779 -12. .878 1. .00 37, .91 N

ATOM 109 CA GLY A 29 72. ,153 2. ,730 -12, .512 1, .00 38. .15 C

ATOM 110 C GLY A 29 72, ,674 1, ,313 -12, .685 1. .00 38. .39 C

ATOM 111 o GLY A 29 71. .937 0. .423 -13, ,114 1. .00 37, .89 0

ATOM 112 N PHE A 30 73. .946 1, .100 -12, .353 1. .00 39, .32 N

ATOM 113 CA PHE A 30 74. ,562 -0. .225 -12, .458 1, .00 39, .93 C

ATOM 114 C PHE A 30 74. .609 -0. ,919 -11, .102 1. .00 39, ,45 C TOM 115 o PHE A 30 74. ,773 -0, ,275 -10, .070 1, .00 40, .04 0

ATOM 116 CB PHE A 30 76. ,002 -0, .123 -12, .971 1, .00 40, .37 C

ATOM 117 CG PHE A 30 76. ,124 0, ,432 -14. .354 1, .00 41, .36 C

ATOM 118 CDl PHE A 30 76. ,436 1. ,774 -14, .554 1. .00 40, .94 C

ATOM 119 CD2 PHE A 30 75. .941 -0. ,393 -15, .465 1. .00 41, .73 C

ATOM 120 CEl PHE A 30 76. .568 2. ,291 -15. .841 1, .00 41, .63 C

ATOM 121 CE2 PHE A 30 76. ,070 0. .111 -16, .760 1, .00 41, .47 C

ATOM 122 CZ PHE A 30 76. ,384 1. ,457 -16, .950 1, .00 41, .25 C

ATOM 123 N PHE A 31 74. .473 -2. ,236 -11, .113 1 .00 39 .36 N

ATOM 124 CA PHE A 31 74. .540 -3. ,020 -9. .893 1, .00 38, .71 C

ATOM 125 C PHE A 31 75. .980 -3. .498 -9, .744 1, .00 39, .23 C

ATOM 126 o PHE A 31 76. .546 -4, .047 -10, .688 1, .00 39, .27 O

ATOM 127 CB PHE A 31 73. .599 -4. .204 -10, .006 1, .00 38, .16 C

ATOM 128 CG PHE A 31 72. .164 -3. .837 -9, .855 1, .00 37, .93 C

ATOM 129 CDl PHE A 31 71. .654 -3. .494 -8. .605 1 .00 36 .22 C Table 3

ATOM 130 CD2 PHE A 31 71. .315 -3. ,821 -10. 958 1. 00 38. 03 c

ATOM 131 CEl PHE A 31 70, .317 -3. ,143 -8. 454 1. 00 36. ,77 c

ATOM 132 CE2 PHE A 31 69, .965 -3. ,467 -10. 815 1. 00 38. ,19 c

ATOM 133 CZ PHE A 31 69, .469 -3. ,128 -9. 557 1. ,00 36. ,80 c

ATOM 134 N LEU A 32 76, .580 -3. ,279 -8. ,575 1. ,00 39. ,11 N

ATOM 135 CA LEU A 32 77, ,959 -3. ,707 -8. ,352 1. ,00 39. ,72 C

ATOM 136 C LEU A 32 78. ,047 -5. ,205 -8. 596 1. 00 40. .18 c

ATOM 137 o LEU A 32 77. ,254 -5. ,972 -8. 048 1. ,00 40. .08 o

ATOM 138 CB LEU A 32 78, ,403 -3. ,395 -6. ,922 1. ,00 40. ,02 c

ATOM 139 CG LEU A 32 79, ,896 -3. ,576 -6. ,645 1. ,00 39. ,28 c

ATOM 140 CDl LEU A 32 80, ,700 -2. ,659 -7. ,556 1. ,00 39, ,53 c

ATOM 141 CD2 LEU A 32 80. ,194 -3. ,263 -5. ,187 1, ,00 39. ,11 c

ATOM 142 N ARG A 33 79, .006 -5. ,621 -9. ,420 1. .00 41. .12 N

ATOM 143 CA ARG A 33 79, .162 -7. ,038 -9. .751 1, .00 41. .65 C

ATOM 144 C ARG A 33 80, ,543 -7. ,605 -9. .427 1. .00 41, .77 C

ATOM 145 o ARG A 33 81. .568 -6, ,987 -9. .720 1, ,00 41, .35 O

ATOM 146 CB ARG A 33 78. .851 -7. .253 -11. ,236 1. ,00 41. .70 c

ATOM 147 CG ARG A 33 79. .046 -8. .686 -11. ,700 1. ,00 42. .74 c

ATOM 148 CD ARG A 33 78. .491 -8. .922 -13. ,089 1. ,00 41. .98 c

ATOM 149 NE ARG A 33 79. .193 -8. ,155 -14. ,113 1, ,00 43, .07 N

ATOM 150 CZ ARG A 33 78. .905 -8. .208 -15. ,413 1, ,00 43, .19 C

ATOM 151 NHl ARG A 33 77. .927 -8. .996 -15. ,848 1, .00 42, .00 N

ATOM 152 NH2 ARG A 33 79, .590 -7, .469 -16. .279 1, ,00 42, .32 N

ATOM 153 N ILE A 34 80, ,561 -8, ,785 -8. .813 1. .00 42. .97 N

ATOM 154 CA ILE A 34 81, .820 -9, .442 -8. .465 1. ,00 44, .25 C

ATOM 155 C ILE A 34 81, .917 -10, .784 -9. .186 1, .00 45, .31 C

ATOM 156 o ILE A 34 81. ,232 -11. ,743 -8. ,837 1. ,00 45. ,06 O

ATOM 157 CB ILE A 34 81. ,957 -9, ,626 -6. ,933 1. ,00 44, ,16 c TOM 158 CGI ILE A 34 82, .190 -8. ,253 -6. .285 1. ,00 43, ,89 c

ATOM 159 CG2 ILE A 34 83, .115 -10. ,575 -6, .604 1. ,00 43, ,90 c

ATOM 160 CDl ILE A 34 82, ,527 -8. ,297 -4. ,818 1, .00 43, ,24 c

ATOM 161 N HIS A 35 82. .766 -10. ,819 -10, ,213 1, .00 47, .73 N TOM 162 CA HIS A 35 82, .984 -12. ,008 -11. ,044 1, .00 49, .67 C

ATOM 163 C HIS A 35 83, .746 -13. .118 -10, ,335 1, .00 50. .49 C

ATOM 164 o HIS A 35 84. .558 -12. .859 -9. ,442 1. .00 50, .08 O

ATOM 165 CB HIS A 35 83. .761 -11, ,638 -12, ,307 1, .00 50, .99 C

ATOM 166 CG HIS A 35 83, ,016 -10. ,736 -13. ,239 1, .00 52. .80 C

ATOM 167 ND1 HIS A 35 81. .950 -11. ,167 -13, ,998 1, ,00 53, .66 N

ATOM 168 CD2 HIS A 35 83. .200 -9, .432 -13. ,551 1, .00 53, .29 C

ATOM 169 CEl HIS A 35 81. .511 -10, .167 -14, .741 1, .00 54, .14 C

ATOM 170 NE2 HIS A 35 82, .252 -9, .102 -14, .488 1. .00 54, .32 N

ATOM 171 N PRO A 36 83, .510 -14, .376 -10, .748 1, .00 51, .42 N TOM 172 CA PRO A 36 84. .171 -15, .543 -10, .158 1, .00 51, .76 C

ATOM 173 C PRO A 36 85. .698 -15, .454 -10, .187 1, .00 52 .11 C

ATOM 174 o PRO A 36 86. .365 -15, .951 -9, .281 1, .00 52, .27 O

ATOM 175 CB PRO A 36 83. .632 -16, .700 -10, .998 1, .00 52 .08 C

ATOM 176 CG PRO A 36 82. ,239 -16, .235 -11. .327 1. .00 52. .48 C

ATOM 177 CD PRO A 36 82. .487 -14. .795 -11. .725 1, .00 51. .66 C

ATOM 178 N ASP A 37 86. .246 -14, ,813 -11. ,217 1, .00 52, .61 N

ATOM 179 CA ASP A 37 87. .696 -14, .685 -11. .328 1, .00 52, .96 c

ATOM 180 C ASP A 37 88, .259 -13, .462 -10. .616 1, .00 52, .62 c

ATOM 181 o ASP A 37 89, .444 -13. .154 -10. .746 1, .00 53, .00 o TOM 182 CB ASP A 37 88. .141 -14. .688 -12. .803 1, .00 54, .40 c

ATOM 183 CG ASP A 37 87. .511 -13, .570 -13. .620 1, .00 55 .76 c

ATOM 184 ODl ASP A 37 86. .310 -13, .676 -13, .962 1 .00 55 .75 o

ATOM 185 OD2 ASP A 37 88. .226 -12, .584 -13, .917 1. .00 56, .34 o TOM 186 N GLY A 38 87. ,410 -12. .761 -9. .868 1, .00 52, .10 N

ATOM 187 CA GLY A 38 87. ,874 -11. .601 -9. .126 1, .00 50. .89 C

ATOM 188 C GLY A 38 87. ,793 -10, ,223 -9. .766 1 .00 50, .43 C

ATOM 189 o GLY A 38 88, .254 -9, .248 -9, .168 1 .00 51, .26 O

ATOM 190 N ARG A 39 87, .222 -10, .115 -10, .960 1, .00 49, .14 N

ATOM 191 CA ARG A 39 87, ,106 -8, .811 -11, .615 1, .00 48. .54 C

ATOM 192 C ARG A 39 85, .884 -8, .066 -11, .060 1, .00 47. .80 C

ATOM 193 o ARG A 39 84, .876 -8, .689 -10, .717 1, .00 47, .58 O

ATOM 194 CB ARG A 39 86, .973 -8, .991 -13, .135 1 .00 47, .72 C

ATOM 195 N VAL A 40 85. .975 -6, .740 -10, .976 1, .00 46, .88 N uo

OOCO mo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooσooooooooooooooooooooooo ιn H(Λ ιnNO 'T 'jι σi θ H I I I θ "di -ϊ ∞ co -r «- θ ' ιn >ι Ni σι oo o ι coro ι 'P "f ιn 'lo

I I I I I I CO

ιn ιn ιnιnιoiD c i ^

"f"»v"»«ιnιnιnιnι v^"f"»"»^^"*flvnn"f^<j^ι nnπnπnrιπnnnn( fnnnιηιηr ιηMrnnfθi N oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo d rH i-H , I d d d d d d d d d ' ri d d

ro o n f θco ιoo _> _>

HO o< _ σi <τι inιn Cθ ocNi "- r~ o ιn m N ∞ m r- c_₄r- ffl oo oo «^)ιn<ι« »ιnιon N lHO ιnιO ln * ιo ^ oo ιoιn»^ιo ^ ^ ιoιoιoιo r" ffl (Λ O ι-l H βl

ooooooooooHHHHHHHH(^lN( !^ιN(^ι^l^l^ι^^nnnn(OMn« « "f "f ^ <»'» v"^ιnlnιnlnιnιnιoιflιoιoιoιDuιfi^otcιo^^^^ - -oιnιniΛinιnιnιnιntΛtnιfi-iιnιnιnιn- ιθι ιnιθ-1-iιn «: <

W COOTW OT W Z Z Z ZZ DDD D DD D D Z Z Z Z Z Z Z Z Z H H H H HH HH

Ϊ Ϊ ΪS Ϊ S UωuUϋ JJJ J J ijμiJOUOOUOUU - d CM H N H IM d CM

< Q O Q Q ω ω < cQ CD O Q CQ O O W N < ffl U O Q rt P3 CJ3 Q W W rt H O Q Q < PQ CJ) Q Cd W rt zoooυozoozzcjooooouzuuoc ouozzυoo υυυozuυouuuozzcjuoooouzooouuoozzυo o m o N NN

00 se

© EoSoSoSo O yE^{H E}-^Ei

Table 3

ATOM 328 N GLU A 58 82.430 -5.783 10.708 1 . 00 32 . 12 N

ATOM 329 CA GLU A 58 83.595 -6.330 11.391 1 . 00 33 . 18 C

ATOM 330 C GLU A 58 83.752 -5.580 12.713 1 . 00 33 . 89 C

ATOM 331 0 GLU A 58 84.270 -6.119 13.695 1 . 00 33 . 53 o

ATOM 332 CB GLU A 58 84.845 -6.173 10.515 1 . 00 34 . 27 C

ATOM 333 CG GLU A 58 85.985 -7.131 10.859 1 . 00 35 . 60 C

ATOM 334 CD GLU A 58 85.594 -8.601 10.725 1 . 00 37 . 03 C

ATOM 335 OEl GLU A 58 84.964 -8.980 9.715 1 . 00 37 . 39 o

ATOM 336 OE2 GLU A 58 85.926 -9.387 11.635 00 39.38 O

ATOM 337 N GLU A 59 83.309 -4.325 12.710 00 34.07 N

ATOM 338 CA GLU A 59 83.308 -3.467 13.891 00 34.95 C

ATOM 339 C GLU A 59 82.302 -2.353 13.593 00 33.54 C

ATOM 340 o GLU A 59 81.825 236 12.465 00 33.43 O

ATOM 341 CB GLU A 59 84.707 904 14.195 00 36.91 C

ATOM 342 CG GLU A 59 85.182 -1.759 13.322 00 40.94 C

ATOM 343 CD GLU A 59 86.539 224 13.774 00 43.27 C

ATOM 344 OEl GLU A 59 87.532 977 13.689 00 45.02 O

ATOM 345 OE2 GLU A 59 86.615 058 14.225 1.00 44.36 O

ATOM 346 N ARG A 60 81.969 -1.550 14.593 1.00 32.58 N

ATOM 347 CA ARG A 60 80.991 -0.486 14.413 00 32.17 C

ATOM 348 C ARG A 60 81.227 0.369 13.154 1.00 31. ,15 C

ATOM 349 o ARG A 60 82.287 0.978 12.988 1.00 30, .43 O

ATOM 350 CB ARG A 60 80.981 0.381 15.676 1.00 33. .58 C

ATOM 351 CG ARG A 60 79.844 1.365 15.781 1.00 36, ,07 C

ATOM 352 CD ARG A 60 79.939 2. .142 17.087 1.00 38, .02 c

ATOM 353 NE ARG A 60 79.379 3. ,472 16.921 1.00 42. ,32 N

ATOM 354 CZ ARG A 60 80.065 4. ,601 17.059 1.00 44. .12 C

ATOM 355 NHl ARG A 60 81.351 4. ,574 17.384 1.00 44. .60 N

ATOM 356 NH2 ARG A 60 79.466 5. ,761 16.829 1.00 46, .46 N

ATOM 357 N GLY A 61 80.245 0. ,383 12.253 1.00 29, .90 N

ATOM 358 CA GLY A 61 80.356 1. .185 11.043 1.00 28, .83 C

ATOM 359 C GLY A 61 81.330 0.720 9.972 1.00 28, .80 C

ATOM 360 o GLY A 61 81.550 1.430 8.986 1.00 28, .16 O

ATOM 361 N VAL A 62 81.913 -0.467 10.148 1, ,00 28, ,29 N

ATOM 362 CA VAL A 62 82.861 -1.000 9.171 1, .00 27, ,10 C

ATOM 363 C VAL A 62 82.384 -2.354 8.646 1, .00 26. .34 C

ATOM 364 o VAL A 62 82.059 -3.248 9.422 1, ,00 25. ,88 O

ATOM 365 CB VAL A 62 84.265 -1.161 9.799 1, ,00 28. .53 C

ATOM 366 CGI VAL A 62 85.279 -1.603 8.723 1, .00 29. .17 C

ATOM 367 CG2 VAL A 62 84.702 0.152 10.450 1, .00 28, .29 C

ATOM 368 N VAL A 63 82.343 -2.517 7.328 1, .00 25. .99 N

ATOM 369 CA VAL A 63 81.878 -3.781 6.762 1, .00 25. .26 C

ATOM 370 C VAL A 63 82.788 -4.378 5.695 1, .00 26. .19 C

ATOM 371 o VAL A 63 83.677 -3.704 .157 1, .00 26. .01 O

ATOM 372 CB VAL A 63 80.474 -3.634 .109 1, .00 24. .65 C

ATOM 373 CGI VAL A 63 79.509 -2.926 .065 1, .00 25, .24 C

ATOM 374 CG2 VAL A 63 80.587 -2.856 .794 1, .00 22, .71 c

ATOM 375 N SER A 64 82.552 -5.655 .405 00 26. 88 N

ATOM 376 CA SER A 64 83.263 -6.358 .341 00 27 . 68 C

ATOM 377 C SER A 64 82.119 -6.687 3.375 00 27 . 92 C

ATOM 378 o SER A 64 80.979 -6.878 3.804 00 28 . 11 O

ATOM 379 CB SER A 64 83.946 -7.646 4.846 00 27 . 31 C

ATOM 380 OG SER A 64 83.020 -8.615 5.315 00 27 . 80 O

ATOM 381 N ILE A 65 82.415 6.712 2.082 00 27 . 99 N

ATOM 382 CA ILE A 65 81.410 6.996 1.068 00 29 . 29 C

ATOM 383 C ILE A 65 81.827 8.241 0.264 00 31 . 00 C

ATOM 384 o ILE A 65 82.841 8.223 -0.439 00 29 . 42 O

ATOM 385 CB ILE A 65 81.258 -5 786 0.121 1.00 29. 51 C

ATOM 386 CGI ILE A 65 80.756 -4 565 0.908 1.00 30 . 05 C TOM 387 CG2 ILE A 65 80.277 -6.117 -0.990 1.00 30 . 34 C

ATOM 388 CDl ILE A 65 80.874 -3.234 0.160 1.00 30 . 18 C

ATOM 389 N LYS A 66 81.032 -9.306 0.356 1.00 31 . 83 N

ATOM 390 CA LYS A 66 81.353 10.560 -0.317 1.00 34 . 62 C TOM 391 C LYS A 66 80.397 10.993 -1.434 1.00 35 . 76 C

ATOM 392 o LYS A 66 79.179 11.031 -1.251 1.00 34 . 62 O

ATOM 393 CB LYS A 66 81.451 11.681 0.737 1.00 35 . 88 C Table S

ATOM 394 CG LYS A 66 81.735 -13.089 0.193 1.00 36.63 C

ATOM 395 CD LYS A 66 81.757 -14.123 1.321 1.00 37.90 c

ATOM 396 CE LYS A 66 81.989 -15.544 0.806 1.00 39.28 c

ATOM 397 NZ LYS A 66 82.226 -16.531 1.919 1.00 39.38 N

ATOM 398 N GLY A 67 80.961 -11.316 -2.597 1.00 37.32 N

ATOM 399 CA GLY A 67 80.146 -11.789 -3.707 1.00 39.35 C

ATOM 400 C GLY A 67 79.760 -13.231 -3.407 1.00 41.10 C

ATOM 401 0 GLY A 67 80.625 -14.104 -3.319 1.00 41.10 o

ATOM 402 N VAL A 68 78.469 -13.488 -3.233 1.00 42.27 N

ATOM 403 CA VAL A 68 78.006 -14.831 -2.908 1.00 44.02 C

ATOM 404 C VAL A 68 78.433 -15.881 -3.933 1.00 45.16 C

ATOM 405 o VAL A 68 79.007 -16.906 -3.560 1.00 45.69 o

ATOM 406 CB VAL A 68 76.465 -14.869 -2.754 1.00 44.56 C

ATOM 407 CGI VAL A 68 76.006 -16.280 -2.426 1.00 44.70 C

ATOM 408 CG2 VAL A 68 76.032 -13.921 -1.639 1.00 45.21 C

ATOM 409 N SER A 69 78.164 -15.631 -5.214 1.00 45.89 N

ATOM 410 CA SER A 69 78.533 -16.582 -6.270 1.00 46.52 C

ATOM 411 C SER A 69 80.036 -16.769 -6.398 1.00 46.52 C

ATOM 412 o SER A 69 80.538 -17.889 -6.308 1.00 46.68 o

ATOM 413 CB SER A 69 77.974 -16.146 -7.630 1.00 47.12 C

ATOM 414 OG SER A 69 76.629 -16.568 -7.798 1.00 47.66 o

ATOM 415 N ALA A 70 80.749 -15.670 -6.609 1.00 46.10 N

ATOM 416 CA ALA A 70 82.193 -15.717 -6.762 1.00 46.16 C

ATOM 417 C ALA A 70 82.905 -16.199 -5.498 1.00 46.34 C

ATOM 418 o ALA A 70 84.060 -16.625 -5.556 1.00 46.73 o

ATOM 419 CB ALA A 70 82.710 -14.344 -7.161 1.00 46.03 C

ATOM 420 N ASN A 71 82.214 -16.134 -4.362 1.00 46.13 N

ATOM 421 CA ASN A 71 82.791 -16.540 -3.080 1.00 46.22 C

ATOM 422 C ASN A 71 84.099 -15.780 -2.820 1.00 45.32 C

ATOM 423 o ASN A 71 85.074 -16.345 -2.323 1.00 44.86 o

ATOM 424 CB ASN A 71 83.025 -18.061 -3.059 1.00 47.52 C

ATOM 425 CG ASN A 71 83.496 -18.578 -1.692 1.00 49.37 C

ATOM 426 ODl ASN A 71 82.985 -18.172 -0.639 1.00 49.71 o

ATOM 427 ND2 ASN A 71 84.464 -19.494 -1.709 1.00 49.93 N

ATOM 428 N ARG A 72 84.100 -14.492 -3.165 1.00 44.62 N TOM 429 CA ARG A 72 85.259 -13.620 -2.980 1.00 43.24 C

ATOM 430 C ARG A 72 84.849 -12.325 -2.265 1.00 43.09 C

ATOM 431 o ARG A 72 83.665 -11.965 -2.247 1.00 42.61 o

ATOM 432 CB ARG A 72 85.890 -13.286 -4.331 1.00 42.91 C

ATOM 433 N TYR A 73 85.836 -11.637 -1.684 1.00 41.68 N

ATOM 434 CA TYR A 73 85.616 -10.398 -0.941 1.00 40.49 C

ATOM 435 C TYR A 73 86.114 -9.166 -1.696 1.00 40.25 C

ATOM 436 o TYR A 73 87.253 -9.145 -2.180 1.00 40.29 o

ATOM 437 CB TYR A 73 86.337 -10.447 0.417 1.00 39.59 C

ATOM 438 CG TYR A 73 85.871 -11.523 1.371 1.00 39.87 C

ATOM 439 CDl TYR A 73 86.428 -12.813 1.341 1.00 40.03 C

ATOM 440 CD2 TYR A 73 84.869 -11.260 2.310 1.00 39.69 C

ATOM 441 CEl TYR A 73 85.988 -13.818 2.228 1.00 39.43 C

ATOM 442 CE2 TYR A 73 84.422 -12.252 3.196 1.00 39.45 c

ATOM 443 CZ TYR A 73 84.983 -13.528 3.148 1.00 39.35 c

ATOM 444 OH TYR A 73 84.513 -14.506 4.000 1.00 38.23 o TOM 445 N LEU A 74 85.273 -8.137 -1.780 1.00 39.02 N

ATOM 446 CA LEU A 74 85.656 -6.899 -2.460 1.00 38.07 C

ATOM 447 C LEU A 74 86.859 -6.288 -1.750 1.00 38.59 C

ATOM 448 0 LEU A 74 86.963 -6.346 -0.524 1.00 38.50 o

ATOM 449 CB LEU A 74 84.515 -5.887 -2.435 1.00 36.96 C

ATOM 450 CG LEU A 74 84.825 -4.568 -3.149 1.00 37.24 c

ATOM 451 CDl LEU A 74 84.673 -4.774 -4.656 1.00 35.39 c

ATOM 452 CD2 LEU A 74 83.870 -3.465 -2.661 1.00 35.55 c

ATOM 453 N ALA A 75 87.768 -5.702 -2.521 1.00 39.32 N

ATOM 454 CA ALA A 75 88.951 -5.085 -1.942 1.00 40.14 C

ATOM 455 C ALA A 75 89.471 -3.946 -2.809 1.00 40.56 C

ATOM 456 o ALA A 75 89.246 -3.917 -4.012 1.00 39.49 o

ATOM 457 CB ALA A 75 90.038 -6.134 -1.746 1.00 40.67 C

ATOM 458 N MET A 76 90.147 -2.996 -2.178 1.00 42.11 N

ATOM 459 CA MET A 76 90.722 -1.874 -2.898 1.00 44.44 C oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooo oooo

H Haιn 7 N aj 'r σι ιθ ιo ιnιη cM c M c

I I I I I I

- cM - alιn »<ΛOlιJlι»O H OlIllJι a) 00

C <M cg <o co<η r ω ωω ω ω _ ωωωω co o) on (lo co oo cD co ω ι_ <D CDCDω ro oo(-ιβ < ^ < < < < <^ < < i ti a: ^ < ι^f < << < < < << < < < < <tt < < < fi <r3i fi (s:

E^H t^H H H t^ι W Kl tl 0i n D D DD D Λ M>ι llι l, ⁽iι ⁽lι ⁽iι >ι < ι ι U U (!H5ø D D D D D D D D D D D D D D D D rt O- O- Q- Pύ O- I^ C C C C CO Pt; M W H U Iim W H U J I w w w ω ω i-i iH rHi jH ^ iH ϊ-)

Esa2asjhijj₁ju!5ι5t5u a; ₁);(ilrt;₍ι;rt:uu(5i52332SJj3H^ιjHiHi J J _hJ _fl J J | J J I W W OT CO C W H^ Hl Hl HP -I

_^ _ _^ H IM rl CM d CM co o a ω < m fζ pa rt moQQ rt ft cu rt nuαα «c m o a < cα rt m o rt m υoc cjc uzuυoυ oυo zuoooooozcjυozυooozooooooozuυooouozϋuouzucjouozucjoo: HN O O ^ ^ ιi"> ιi">

ooooooooooooooooooooo

"4 oυo o ozυoooυυzυooooυz oo oo o o o z o Oo υ z υoooOTZooouoυoouυzoo ooooυυu uzυo ooo

rl ( oooooooooooooooσooooooooooooooooooooooooooooooooooooooσooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo d d d d d d d d i-H d d d d d d d d i-l d d d d d d d d d d i-l d d d rH d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d

o _ -o r- n o ro

'f " "f "I Λιnιn ln l O GO rtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrt cciLiιai_iι i-4 aj a, Doθ D ωω ω ω ωω ω ω wnnwn ιJιJri κasιi!XBaii!!i!a aBa:aaϊκaκffiaaa κιιis rt rt rt rt rtcs u o αi c cii i-i P- c tt. αi αi Qi ciiPu fc i-j Cu c

CM CM CM C CMM CCMM d CCMM d CCMM ft CQ O rt CQ CJ) U rt CQ O CJ) rt CO CJ) Q α rt Q ft O O < (O O D Q W W N ft (O O Q D W W N rt w u o oo o z υo o u o o z oυ o υ o o z oo oυooozυ υ oc z o υ o u co z υ υ ocjcjυ υoou z υoooc o υυoo z υoo oo o r~ oo ^θ H CM C ^ ιncD r- oo σ> o CM rθ 'r ιn co r-- co cno c <θ " in c_ r'- o Λ θ ( rn ^ ι ^ C CMM CCMM << Mr rr (c Pfi rMθ ffθθ ff <c^ rno rno »»-- 'ιi ^^ι '-»ι «^ "* ') 'r 'r 'jι ιn ιθ ιo ιn ιn ιn ιn ιθ ιθ ιn cD co vD D co D co o i ιθΛ ι.θΛ .-")i iiπri iι r ^ ^ ^ ^ ^ ^ L/₎ ^ ^ ^ ^

00 πri .ι i .-r")i iri .-r"i> .m .-iθ .-r->i i-oi .ιn .-ri .ιΛ .-"> .uroj ^ ^ i ^ tf^ i t^ i^ ^ ^ ^ ^ ^ i/^ rH se

© aaaaaaaaasaaasssasaasasaasasaaaaaaaaaEsaaaaaaaEsaaaaEaassaaaEaaass o ^Eo1 to^, to^, fo^< to^< fo^< to^H to^H EotoEoHtoto^H to^, to^< to^, HooHohotoi toi HoHo < < < < < < < < < < < < <

υ uc υ o z u u ou uoo ozo υ o u υ uzo z z z o uoou uυ z o υo o υ υ o o z o uo cjo zo oocjoo z z uoo oooz zυ rl- ro δ o

H U _> < "- o co ιn -ϊ i"i ιn m ιn ιn r~ ro σϊ M M «* σι ιn σι ιn o m cM t^ _> ω mNO_O (n ιI! N αl O H » ₉ O(D OO<M ln Φ ^ ιno^ ω^ Oln α^ αl<»(ΛO H ^0 - ωιι ^ vι»l H ON n ^r (1 H (M0(ι^ - <ll O ^ι ι^,ι ooHl0 ι^,)ιflιι)O H «

^ "^ ιn Φιn m o H om ol Ol o eo ιn ln "» ^ H ^ Φ (Dω ^ ιΛ - lnu) lnΦ ι - Φ _ ι0^ ωΛ OΦ ω co ^ ^ ιo o Φ vn π ln _ _ _ ι H O^ l "l^l ^ ιn» ro r cθf r csi < r c cNi<M (θ CM r o rπ fθ '3^, ^ ^ ^ ^ ^ooc c o^ ( c r f c <or c c c (θ ^ r c ooooooooooooo oooooσ ooooooo ooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooσoooo rH rH i-H H H d I r-l d d d d d d d d d , "^HO "^ - 0"» ^ ooσl ^ . ι^o !

_ι co co c olιo n ιη N - O(

un ιn ιn σι m σι σι<Λσ»σi (Tι (Λ (ΛiJiΦΛθθθθθoooooo o ooo oo o o o o o oo d d d d d i-l iH d d d d d d d d d d d d d d d d ^ft < < < < < < << < <ft< ft <^ << < < < < < < < < ft << < < < < ft < <<< < < ft < ft< ft ft ft ft ft ft < < < ft ft < ft ω ω ω ωωD D D D D D D D DOOCJ)O Ci⁾ OOOOCJ)CJ)DD DDDD D D D D D DD D DDDP, P, C-; p-(-;p, Z Z Z Z ^. ZZZZ Z Z Z Z Z Z Z Z Z Z P- P- a κ κ iBB J ^j H^ ^j Hq ^j H3 Hq H52«ij 2 cij C« « Pή pc;cci ύ pή ω ω ω w ω i-j i C Dj cijO U U cJ O U OUU rt rt rt rt rt S rt rt ^rt rt Hi Hi Hi Hq i-i Hi Hi H oo u -* -* - < < b fr>

H CM H CM d CM H IM H N d CM H CM H IM

^Q a ω ω isi r ca o a ω ω (n uQiii iϊi; O U Q Q co e> a ω ω ft CQ CJ) f PQ O Q Q <t CQ U Q O ft u o u o o z u u o ou u o oz o oo o uozozzz uoou o ou z ooo u uuoo z uoooozu oouooz zu u oo u o z zu

Table 3

ATOM 658 C TYR A 103 73.419 6.488 0.608 1.00 26.83 C

ATOM 659 o TYR A 103 73.727 7.195 1.568 1.00 25.26 o

ATOM 660 CB TYR A 103 72.874 7.485 -1.600 1.00 27.20 c

ATOM 661 CG TYR A 103 71.882 7.684 -2.719 1.00 28.12 c

ATOM 662 CDl TYR A 103 71.564 6.640 -3.586 1.00 27.59 c

ATOM 663 CD2 TYR A 103 71.281 8.930 -2.932 1.00 27.54 c

ATOM 664 CEl TYR A 103 70.685 6.830 -4.638 1.00 28.35 c

ATOM 665 CE2 TYR A 103 70.395 9.130 -3.981 1.00 28.24 c

ATOM 666 CZ TYR A 103 70.101 8.080 -4.828 1.00 28.25 c

ATOM 667 OH TYR A 103 69.215 8.265 -5.856 1.00 28.55 o

ATOM 668 N ASN A 104 74.032 5.343 0.313 1.00 25.83 N

ATOM 669 CA ASN A 104 75.146 4.842 1.112 1.00 25.48 c

ATOM 670 C ASN A 104 76.486 5.082 0.417 1.00 24.49 c

ATOM 671 o ASN A 104 76.544 5.176 -0.803 1.00 24.92 o

ATOM 672 CB ASN A 104 75.006 3.333 1.337 1.00 25.94 c

ATOM 673 CG ASN A 104 73.980 2.983 2.400 1.00 27.69 c

ATOM 674 ODl ASN A 104 73.342 3.860 2.998 1.00 25.70 o

ATOM 675 ND2 ASN A 104 73.819 1.680 2.646 1.00 26.43 N

ATOM 676 N THR A 105 77.555 5.186 1.198 1.00 24.18 N

ATOM 677 CA THR A 105 78.901 5.317 0.636 1.00 24.45 C

ATOM 678 C THR A 105 79.805 4.316 1.370 1.00 24.99 c

ATOM 679 o THR A 105 79.577 3.995 2.542 1.00 23.75 o

ATOM 680 CB THR A 105 79.534 6.703 0.838 1.00 23.48 c

ATOM 681 OG1 THR A 105 79.479 7.037 2.230 1.00 24.08 o

ATOM 682 CG2 THR A 105 78.852 7.752 -0.026 1.00 23.94 c

ATOM 683 N TYR A 106 80.828 3.839 0.672 1.00 25.52 N

ATOM 684 CA TYR A 106 81.768 2.873 1.222 1.00 27.52 C

ATOM 685 C TYR A 106 83.191 3.402 1.052 1.00 29.31 C

ATOM 686 o TYR A 106 83.715 3.461 -0.064 1.00 29.05 o

ATOM 687 CB TYR A 106 81.577 1.531 0.504 1.00 26.36 c

ATOM 688 CG TYR A 106 80.223 0.933 0.807 1.00 24.59 c

ATOM 689 CDl TYR A 106 79.982 0.278 2.024 1.00 23.67 c

ATOM 690 CD2 TYR A 106 79.149 1.120 -0.065 1.00 23.83 c

ATOM 691 CEl TYR A 106 78.690 -0.169 2.367 1.00 24.28 c

ATOM 692 CE2 TYR A 106 77.852 0.682 0.268 1.00 24.28 c

ATOM 693 CZ TYR A 106 77.628 0.044 1.479 1.00 23.75 c

ATOM 694 OH TYR A 106 76.338 -0.348 1.807 1.00 23.41 o

ATOM 695 N ARG A 107 83.793 3.804 2.167 1.00 31.22 N

ATOM 696 CA ARG A 107 85.142 4.369 2.182 1.00 33.44 C

ATOM 697 C ARG A 107 86.175 3.400 2.788 1.00 33.71 C

ATOM 698 o ARG A 107 85.979 2.870 3.874 1.00 32.90 o

ATOM 699 CB ARG A 107 85.110 5.693 2.961 1.00 33.34 c

ATOM 700 CG ARG A 107 86.390 6.517 2.919 1.00 33.84 c

ATOM 701 CD ARG A 107 86.147 7.883 3.550 1.00 33.44 c

ATOM 702 NE ARG A 107 85.639 7.773 4.919 1.00 33.98 N

ATOM 703 CZ ARG A 107 86.396 7.548 5.991 1.00 35.38 C

ATOM 704 NHl ARG A 107 87.712 7.415 5.861 1.00 37.25 N

ATOM 705 NH2 ARG A 107 85.840 7.418 7.191 1.00 34.53 N

ATOM 706 N SER A 108 87.266 3.177 2.060 1.00 36.11 N

ATOM 707 CA SER A 108 88.345 2.270 2.475 1.00 37.06 C

ATOM 708 C SER A 108 88.890 2.572 3.866 1.00 37.88 C

ATOM 709 o SER A 108 89.251 3.713 4.162 1.00 37.86 o

ATOM 710 CB SER A 108 89.494 2.342 1.464 1.00 37.14 C

ATOM 711 OG SER A 108 90.533 1.433 1.779 1.00 38.83 o

ATOM 712 N ARG A 109 88.957 1.555 4.724 1.00 38.90 N

ATOM 713 CA ARG A 109 89.485 1.779 6.063 1.00 40.45 C

ATOM 714 C ARG A 109 91.011 1.889 6.005 1.00 41.31 C

ATOM 715 o ARG A 109 91.630 2.487 6.886 1.00 40.95 o

ATOM 716 CB ARG A 109 89.078 0.657 7.020 1.00 40.32 C

ATOM 717 CG ARG A 109 89.395 0.986 8.476 1.00 41.68 C

ATOM 718 CD ARG A 109 88.858 -0.060 9.446 1.00 42.89 C

ATOM 719 NE ARG A 109 89.418 -1.384 9.187 1.00 45.20 N

ATOM 720 CZ ARG A 109 89.221 -2.452 9.959 1.00 45.77 C

ATOM 721 NHl ARG A 109 88.471 -2.362 11.049 1.00 46.70 N

ATOM 722 NH2 ARG A 109 89.783 -3.615 9.648 1.00 45.83 N

ATOM 723 N LYS A 110 91.604 1.319 4.959 1.00 42.40 N Table 3

ATOM 724 CA LYS A 110 93.061 1.363 4.779 1.00 44.16 c

ATOM 725 C LYS A 110 93.474 2.688 4.128 1.00 44.71 c

ATOM 726 o LYS A 110 94.231 3.472 4.711 1.00 44.66 o

ATOM 727 CB LYS A 110 93.522 0.188 3.908 1.00 43.41 c

ATOM 728 N TYR A 111 92.972 2.928 2.918 1.00 44.79 N

ATOM 729 CA TYR A 111 93.257 4.159 2.184 1.00 45.33 C TOM 730 C TYR A 111 92.041 5.041 2.440 1.00 45.58 C

ATOM 731 o TYR A 111 91.143 5.160 1.606 1.00 45.68 o

ATOM 732 CB TYR A 111 93.417 3.834 0.704 1.00 46.39 C

ATOM 733 CG TYR A 111 94.310 2.631 0.495 1.00 48.08 C

ATOM 734 CDl TYR A 111 95.651 2.659 0.881 1.00 48.44 C

ATOM 735 CD2 TYR A 111 93.797 1.440 -0.016 1.00 48.53 c

ATOM 736 CEl TYR A 111 96.457 1.528 0.770 1.00 49.53 c

ATOM 737 CE2 TYR A 111 94.591 0.303 -0.131 1.00 49.37 c

ATOM 738 CZ TYR A 111 95.920 0.351 0.266 1.00 50.10 c

ATOM 739 OH TYR A 111 96.695 -0.787 0.186 1.00 50.23 o

ATOM 740 N THR A 112 92.037 5.652 3.620 1.00 45.88 N

ATOM 741 CA THR A 112 90.937 6.477 4.112 1.00 45.92 C

ATOM 742 C THR A 112 90.372 7.631 3.291 1.00 46.09 C

ATOM 743 o THR A 112 89.499 8.354 3.783 1.00 46.15 o

ATOM 744 CB THR A 112 91.274 7.047 5.485 1.00 45.93 c

ATOM 745 OG1 THR A 112 92.262 8.072 5.337 1.00 46.22 o

ATOM 746 CG2 THR A 112 91.805 5.952 6.395 1.00 46.03 c

ATOM 747 N SER A 113 90.826 7.819 2.059 1.00 45.29 N

ATOM 748 CA SER A 113 90.295 8.924 1.270 1.00 44.93 C

ATOM 749 C SER A 113 89.594 8.456 0.006 1.00 43.95 C

ATOM 750 o SER A 113 88.935 9.245 -0.670 1.00 43.68 o

ATOM 751 CB SER A 113 91.417 9.870 0.869 1.00 46.51 C

ATOM 752 OG SER A 113 92.182 9.282 -0.168 1.00 48.39 o

ATOM 753 N TRP A 114 89.746 7.177 -0.319 1.00 42.46 N

ATOM 754 CA TRP A 114 89.140 6.628 -1.521 1.00 41.49 C

ATOM 755 C TRP A 114 87.816 5.892 -1.270 1.00 40.48 C

ATOM 756 o TRP A 114 87.626 5.255 -0.233 1.00 39.86 o

ATOM 757 CB TRP A 114 90.136 5.697 -2.227 1.00 41.54 C

ATOM 758 N TYR A 115 86.916 5.986 -2.246 1.00 39.44 N

ATOM 759 CA TYR A 115 85.598 5.364 -2.180 1.00 38.58 C

ATOM 760 C TYR A 115 85.381 4.306 -3.250 1.00 37.61 C

ATOM 761 o TYR A 115 85.971 4.359 -4.324 1.00 38.60 o

ATOM 762 CB TYR A 115 84.489 6.413 -2.377 1.00 39.18 C

ATOM 763 CG TYR A 115 84.357 7.433 -1.277 1.00 38.67 C

ATOM 764 CDl TYR A 115 85.127 8.597 -1.277 1.00 39.24 C

ATOM 765 CD2 TYR A 115 83.477 7.223 -0.221 1.00 38.75 C

ATOM 766 CEl TYR A 115 85.022 9.532 -0.243 1.00 39.67 C

ATOM 767 CE2 TYR A 115 83.362 8.143 0.818 1.00 39.61 C

ATOM 768 CZ TYR A 115 84.137 9.300 0.804 1.00 40.08 C

ATOM 769 OH TYR A 115 84.014 10.209 1.836 1.00 39.83 o

ATOM 770 N VAL A 116 84.514 3.349 -2.945 1.00 36.63 N

ATOM 771 CA VAL A 116 84.136 2.320 -3.899 1.00 35.26 C

ATOM 772 C VAL A 116 83.257 3.123 -4.847 1.00 36.10 C

ATOM 773 o VAL A 116 82.389 3.872 -4.394 1.00 36.77 o

ATOM 774 CB VAL A 116 83.267 1.221 -3.231 1.00 33.90 C

ATOM 775 CGI VAL A 116 82.773 0.220 -4.281 1.00 31.71 C

ATOM 776 CG2 VAL A 116 84.068 0.515 -2.151 1.00 33.37 C

ATOM 777 N ALA A 117 83.463 2.980 -6.147 1.00 36.82 N

ATOM 778 CA ALA A 117 82.676 3.747 -7.096 1.00 37.68 C

ATOM 779 C ALA A 117 82.654 3.144 -8.486 1.00 38.75 C

ATOM 780 o ALA A 117 83.542 2.378 -8.866 1.00 38.92 o

ATOM 781 CB ALA A 117 83.212 5.180 -7.161 1.00 37.78 C

ATOM 782 N LEU A 118 81.621 3.496 -9.242 1.00 39.82 N

ATOM 783 CA LEU A 118 81.461 3.014 -10.606 1.00 40.49 C

ATOM 784 C LEU A 118 81.371 4.200 -11.551 1.00 41.61 C

ATOM 785 o LEU A 118 80.875 5.258 -11.166 1.00 42.32 o

ATOM 786 CB LEU A 118 80.200 2.167 -10.723 1.00 40.77 C

ATOM 787 CG LEU A 118 80.254 0.818 -10.000 1.00 42.07 C

ATOM 788 CDl LEU A 118 78.951 0.057 -10.239 1.00 41.45 C

ATOM 789 CD2 LEU A 118 81.446 0.003 -10.516 1.00 41.56 C oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H _d d d H H _d H H H H rl H H H H H H H H H H H H H H d H d d d rl d d d H H H H H H d H H H H H H H H H H H H H H H H H H H d

_C ro cM in ro

N Φ OΦ

Oθ m<Λ<Il

-r 10 T n -r co so ■ ^ M^ι n (ι| ri n N "|ⁱ rl O O H OO O rt O O H N N O O N N O O O H O H O H N W n ιfl Φ M» O V ι|^| ιn ill Λ « lO li r- W r- en o r- _> I I I I I I I I I I I I H n o"ι^ι oo l riπ ι^,ι

Λ O O O o o H H H H H H H N (M ^ι ^ι c^ {η (η (0 ^^,^ ^»l (¹^ ^η l^ι ^ ^ q^, "^^■ 1^^, " "^ ^ ^ ^ "r 1l^, ιO ln ιO l ι ln ιO ιO ι Φ Φ ιo y) ^ ^ ^ oo α) oo

H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM M d H H H d d H H d H d H d d d H H H H H H H H H H H H H d H H H H H rl rl d rl H H H H H H H rl H H rl H H H H H H H H H H H H H

CO CO W CO CO O CD U CJ O P- C-; p. o- o- o; o, >^ >H < >H Z z z z z z z z o- ι; α3 o- p. -; α: piJ p- PS pS co co co co co co co co co D D D D D ^ lH H ^ p- p- piJ pci cC pi; H π >< ι ι o; ρι; p£; (ϊ| β; aB -3 K ffi S! S S J j Hl J l^jHl Hl j H⁾ lJ J J Hl >1 >1 >1 >H >1 l H j Hq Hl ^ i rt rt rt rt rt H EH EH EH EH EH j ^ H3 Hl Hq Hl HP J H) Hq HP HP Hl H5 Cj) C) J) C) O O W CO d CM

< ce rt cQ rt m CJ> cj> ft t moαωw <; nooonmNa «c O U Q H N rt m rt ft CQ CJ) zoooozououzuoooou z u u o zcjuocjuc ozzooouoouυcjuozcjuoυuuc zzuυocjzυo o z υ o o CJ o m C r r COf rι C fOj C c) 'J^, "- 'Ii ' —ϊi ' —r ^ ^i ' ^Jι ι un; C_Oι0_0 CO

oooooooooσooσooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo rH τH ri r < I ri ri rH ri ri rH r rH \ rH rH rH i ^

N OM!V N H ιn (M -) H ιn ιn o o ι»l H ( CΛ oo (D a^ H < oo o ^ ( * m Φ<M H Λ ! 0 "l' N Ol ^ N H "l' M lI) H (D ln ^ o ^ m H lnιΛv ^ H r- ιΛ ^ o^ ^ ln » ( H ^ n o m H a! ^ (^,) O H ^ ιn N ln o ln n lfl ^ Φ Φ (N H C^ '^ Φ ^ ιn n ln t" Φ O l ^ ιtι n o c1| « H n ln ol a> ιIl n o Φ f H l m r~ ^" <n m <n Φi_> Oo Oo Λir) nr ι(MN nco ^r- c_o N ^ o ι 5l o ^f tM Ol Φ (Jl Φ ^^ Φ Φ O (Λ ^ H lJ> oo o H m n <o H ι») ln Φ n w N m <M H O n Φ ( H ln Φ "f o m ^

(D r- co <τι co co ι ' ιn '* cθ 'ii (θ ( ro M H d H θ θ H M ^ ιn ιn co c-) ιr) - ι_ι r~ (_ r- r~ co oo r~ σι σ< o H C_ co r~ r^ σ> _> 'jⁱ '» m r (O 'ϊ' C τ

I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I H H H I I I I I I I I I I I I I I I I I I

I I I ro ^" m ^ H "r ιΛ ω "» aι o fl o> ^ (D ^ o ω ln ι ^ H m m ιn "^ Φ Φ H o n "J φ c^ l ln n N <n o lfl <Λ ι»l H m (M ι^,l ιfl H ^ co n l⁾\ f^ ⁽^ o ^ _

00 O VO o c _D oo ^ O (» W H H ^^ ιM OO ι oo H ω Φ W ^ιι ( "^ m ln Φ l Φ m ^l H O <M _ o^ ιn Φ ι^,1 ^ < v ^ <Λ ^^■ ιn a> "f ln ^ <!o ^ eo < <D co ιD ln Φ H Φ ID r- Λ D CMl "» Φ ω H (η H lM n ^ ιη > Ol O ιn ri ^ r "l^ι m ιη ^ ι^,) Φ ^ (M a) ιn ^ "ι^, ln ^ (M n H f^ _ o ιι^ o Φ (O Φ ^ ιn o! ιn m a! d Φ βι r• » (M ιI^ n " f^ oo σι <τι o σι m <Λ θ H co co [~ H CN H M n ro n m "- f ^ι^, ' '»ι i' ( C H H H <N d θ CM H θ m co H o o o o σi MO ii MO Φ in r^ oo ai oi Φ in iO Mii o σi

H H H H H ro co H iΛ N θ N H iη f o o (D ιn o ι)l ln π 1» ln Φ d N N o sι iD ^ iJ a) Φ ^ ^ Φ h * ιn ι ) >f π n N o n 9 in d oo Φ θ o m a) d n 9 M^| ι/ι a) t" x ^ «) ^ "ii (^,) N iΛ oι o θ d θ oa) oi d θ N d i£i ιn ιo ιn ιo ιn Φ ^ co oo co <» <D oo co co Go co co cx> Go co oo co co co co co Go co a) co co r- cx> <x> r-^,* t^ _ ao co co oo [^ r^ r"- r r^ r'~ [^ r^ r^ r r^ GO CO D CO O^

⁽Il Ol ⁽n ιJl m o o o o o o o H d ι « ^l ( ^M N ( ι^ n n M ^ v v « fl v <» "|l "f ln ln ln ln ln ιn lJ) ln l Φ Φ Φ ι~^■ ^ ^ ^ ^ ω ωoo _ al O) a) _

CM CM CM CM CM r ro ro ro ro <0 (0 ( ro ro ro f r ro ro ro ro f ( i ro r io c < <^ ro < < ro ro ro M

H H H H H H H H H H H H H H H H H H H H H H H H H H rl H H H H H H H H H H H H H H d H H H H H H H H H H H d H H H H H d H H H d H H ft ft et et < rt ft < < ft < < < < a: < < ft < < < < < t* < < < < < < < < < ft < < < < < < tt < < < < < < < < ft < < ft ft < < rt < < < w w co co c pι; ή P- c-; p- -; 5 >-" >H ι H θ o o o o o o H >H ι -ι z z z z z z z z -3 c c o o o) w rt rt rt rt rt « ω w c-i ι_i (_ c-ι ω D D D D D D P D

^ ^ ^ ^ ^ K K K ϊ a a a j j j j Bj K H oi oi i- i- Hi j Hi Hi hJ Hi J j ₁j ₁j _hj Ht ^ >₁ . >ι ι >ι ι >ι !M j 3 3 ιJ j j j i J j i J j ω iii ω iιi ω M i. M

J j μi J J ^ h H h h h fri U O O O fe Λ ft ft ft fe ft J U - O J lJ U ei U ϋ iJ U CJ J ^" J ^" J ^" ϋ ^" J - ϋ ^{" " "} ~ ft ft < i ri H H H H J ^' J ^' J ^' J ^' J ^' j ^' μ ^'i iJ ^'

H CM d lM H CM H H CM a. m rt ωocj) rt < mop rt m CJ> a ω ω rt OIUQU H < ω BCDUQ < ωuoQ zυuoozoooooozoυozυυoυuozooozuuouυoozzυυoυυoυzzυooυzoooυooυzoυooooo ιn Φ ι ) Ol O H H d d d d N (

oΞΞEEoo∑o∑oaEoo∑ rtrtrtrtrtrtrt

Table 3

ATOM 922 N PHE A 139 75.516 4.655 -3.495 00 26.91 N

ATOM 923 CA PHE A 139 74.851 3.368 -3.706 00 26.74 C

ATOM 924 C PHE A 139 73.584 3.210 866 00 27.02 C

ATOM 925 0 PHE A 139 73.475 3.730 758 00 25.58 O

ATOM 926 CB PHE A 139 75.801 2.198 383 00 27.16 C

ATOM 927 CG PHE A 139 76.989 2.089 311 00 27.58 C

ATOM 928 CDl PHE A 139 78.119 893 130 00 27.23 C

ATOM 929 CD2 PHE A 139 76.973 179 -5.375 00 27.34 C

ATOM 930 CEl PHE A 139 79.228 786 -5.007 00 27.33 C

ATOM 931 CE2 PHE A 139 78.064 066 -6.253 00 26.45 C

ATOM 932 CZ PHE A 139 79.192 1.868 -6.070 1.00 26.09 C

ATOM 933 N LEU A 140 72.638 2.450 402 1.00 26.95 N

ATOM 934 CA LEU A 140 71.385 2.199 723 1.00 27.05 C

ATOM 935 C LEU A 140 71.262 0.701 504 1.00 27.88 C

ATOM 936 o LEU A 140 71.153 0.058 461 1.00 28.79 O

ATOM 937 CB LEU A 140 70.228 2.708 3.591 1.00 26.81 C

ATOM 938 CG LEU A 140 68.802 2 552 3.055 1.00 26.55 C

ATOM 939 CDl LEU A 140 68.691 3 334 .760 1.00 27.17 C

ATOM 940 CD2 LEU A 140 67.784 3 057 .090 1.00 25.60 C

ATOM 941 N PRO A 141 71.287 0 246 .239 1.00 28.65 N

ATOM 942 CA PRO A 141 71.171 -1 201 -1.015 1.00 30.03 C

ATOM 943 C PRO A 141 69.762 -1 677 -1.358 1.00 30.80 C

ATOM 944 o PRO A 141 68.777 -1 062 -0.945 1.00 31.23 O

ATOM 945 CB PRO A 141 71.502 -1.341 0.472 00 29.16 C

ATOM 946 CG PRO A 141 70.894 -0.089 1.053 00 29.20 C

ATOM 947 CD PRO A 141 71.285 0.987 0.035 00 28.56 c

ATOM 948 N MET A 142 69.670 -2.758 -2.124 00 32.42 N

ATOM 949 CA MET A 142 68.378 -3.298 -2.531 00 34.31 C

ATOM 950 C MET A 142 68.296 -4.795 -2.277 00 35.79 C

ATOM 951 o MET A 142 69.318 -5.486 -2.227 00 36.15 O

ATOM 952 CB MET A 142 68.143 -3.025 -4.018 00 34.61 C

ATOM 953 CG MET A 142 68.149 -1.553 -4.402 1.00 33.78 C

ATOM 954 SD MET A 142 67.851 -1.331 157 1.00 34.38 S

ATOM 955 CE MET A 142 66.113 -1.835 255 1.00 34.37 C

ATOM 956 N SER A 143 67.075 -5.291 132 1.00 37.37 N

ATOM 957 CA SER A 143 66.848 -6.707 -1.883 1.00 39.58 C

ATOM 958 C SER A 143 67.342 -7.591 -3.020 1.00 40.67 C

ATOM 959 o SER A 143 67.277 -7.215 193 1.00 39.83 O

ATOM 960 CB SER A 143 65.360 -6.966 ,652 00 39.84 C

ATOM 961 OG SER A 143 65.143 -8.328 -1.337 00 41.58 O

ATOM 962 N ALA A 144 67.842 -8.770 662 00 42.94 N

ATOM 963 CA ALA A 144 68.327 -9.715 659 00 45.52 C

ATOM 964 C ALA A 144 67.165 -10.596 -4.135 00 47.20 C

ATOM 965 o ALA A 144 67.364 -11.740 -4.528 00 48.00 O

ATOM 966 CB ALA A 144 69.453 -10.571 -3.083 00 44.42 C

ATOM 967 N LYS A 145 65.954 -10.037 -4.103 00 49.35 N

ATOM 968 CA LYS A 145 64.739 -10.732 -4.536 00 50.42 C

ATOM 969 C LYS A 145 64.599 -12.067 -3.830 1.00 51.05 C

ATOM 970 o LYS A 145 64.318 -12.015 -2.615 1.00 51.85 O

ATOM 971 CB LYS A 145 64.749 -10.954 -6.053 1.00 50.92 C

TER 972 LYS A 145

ATOM 973 N HIS B 16 29.691 59.874 -5.987 00 41.20 N

ATOM 974 CA HIS B 16 30.532 60.667 -6.938 00 40.87 C

ATOM 975 C HIS B 16 32.001 60.521 -6.563 00 39.74 C

ATOM 976 o HIS B 16 32.413 60.901 -5.467 00 39.06 O

ATOM 977 CB HIS B 16 30.131 62.149 -6.894 00 41.47 C

ATOM 978 N PHE B 17 32.783 59.981 -7.489 00 38.43 N

ATOM 979 CA PHE B 17 34.203 59.742 -7.270 00 37.73 C

ATOM 980 C PHE B 17 35.047 60.975 -6.928 1.00 37.15 C

ATOM 981 o PHE B 17 36.062 60.855 -6.240 1.00 36.85 O

ATOM 982 CB PHE B 17 34.784 59.027 -8.494 1.00 36.91 C

ATOM 983 CG PHE B 17 34.834 59.876 -9.724 1.00 35.74 C

ATOM 984 CDl PHE B 17 35.928 60.696 -9.969 1.00 35.10 C

ATOM 985 CD2 PHE B 17 33.794 59.855 -10.646 1.00 35.94 C

ATOM 986 CEl PHE B 17 35.988 61.480 -11.112 1.00 35.16 C

ATOM 987 CE2 PHE B 17 33.846 60.640 -11.800 1.00 36.07 C Table 3

ATOM 988 CZ PHE B 17 34.944 61.453 -12.032 ,00 35.19 C

ATOM 989 N LYS B 18 34.641 62.154 -7.392 ,00 37.23 N

ATOM 990 CA LYS B 18 35.420 63.355 -7.092 .00 38.08 C

ATOM 991 C LYS B 18 35.185 63.943 -5.698 ,00 38.08 C

ATOM 992 0 LYS B 18 35.948 64.798 -5.244 ,00 38.20 o

ATOM 993 CB LYS B 18 35.231 64.432 -8.171 ,00 39.65 c

ATOM 994 CG LYS B 18 33.845 64.545 -8.774 ,00 42.73 c

ATOM 995 CD LYS B 18 33.890 65.478 -9.994 1.00 43.91 c

ATOM 996 CE LYS B 18 32.555 65.512 -10.725 1.00 44.63 c

ATOM 997 NZ LYS B 18 32.139 64.155 -11.160 1.00 46.27 N

ATOM 998 N ASP B 19 34.158 63.462 -5.007 1.00 37.77 N

ATOM 999 CA ASP B 19 33.864 63.942 -3.661 1.00 38.47 C

ATOM 1000 C ASP B 19 34.811 63.344 -2.620 1.00 38.55 C

ATOM 1001 0 ASP B 19 35.267 62.202 -2.763 1.00 37.81 O

ATOM 1002 CB ASP B 19 32.431 63.580 -3.263 1.00 39.90 C

ATOM 1003 CG ASP B 19 31.384 64.268 -4.122 1.00 41.14 C

ATOM 1004 ODl ASP B 19 30.214 63.826 -4.091 1.00 41.72 O

ATOM 1005 OD2 ASP B 19 31.724 65.253 -4.814 1.00 42.42 O

ATOM 1006 N PRO B 20 35.132 64.121 -1.566 1.00 38.54 N

ATOM 1007 CA PRO B 20 36.016 63.650 -0.497 1.00 38.26 C

ATOM 1008 C PRO B 20 35.346 62.480 0.226 1.00 37.93 C

ATOM 1009 0 PRO B 20 34.129 62.302 0.135 00 37.55 O

ATOM 1010 CB PRO B 20 36.182 64.886 0.397 00 39.27 C

ATOM 1011 CG PRO B 20 34.945 65.690 0.133 00 39.95 C

ATOM 1012 CD RO B 20 34.776 65.539 .361 00 39.71 C

ATOM 1013 N LYS B 21 36.128 61.684 ,945 00 37.56 N

ATOM 1014 CA LYS B 21 35.566 60.514 .624 1.00 38.03 C

ATOM 1015 C LYS B 21 36.277 60.213 .922 1.00 37.58 C

ATOM 1016 0 LYS B 21 37.356 60.736 3.195 1.00 37.36 O

ATOM 1017 CB LYS B 21 35.718 59.232 0.773 1.00 38.55 C

ATOM 1018 CG LYS B 21 35.458 59.310 -0.726 1.00 40.40 C

ATOM 1019 CD LYS B 21 36.141 58.119 -1.403 00 42.66 C

ATOM 1020 CE LYS B 21 36.004 58.118 -2.931 00 45.28 C

ATOM 1021 NZ LYS B 21 34.693 57.570 -3.390 00 46.79 N

ATOM 1022 N ARG B 22 35.660 59.338 3.705 00 36.89 N

ATOM 1023 CA ARG B 22 36.254 58.875 4. .942 00 36.76 C

ATOM 1024 C ARG B 22 36.607 57.442 4..575 00 35.99 C

ATOM 1025 0 ARG B 22 35.878 56.812 3..807 00 36.59 O

ATOM 1026 CB ARG B 22 35.244 58.835 6..088 00 37.88 C

ATOM 1027 CG ARG B 22 34.503 60.125 6.396 1.00 40.72 C

ATOM 1028 CD ARG B 22 33.663 59.899 7.650 1.00 42.38 C

ATOM 1029 NE ARG B 22 32.359 60.562 7.626 1.00 45.73 N

ATOM 1030 CZ ARG B 22 32.137 61.830 7.961 00 46.48 C

ATOM 1031 NHl ARG B 22 33.137 62.608 8.355 00 48.50 N

ATOM 1032 NH2 ARG B 22 30.904 62.320 7.909 00 47.02 N

ATOM 1033 N LEU B 23 37.725 56.938 5.085 00 34.47 N

ATOM 1034 CA LEU B 23 38.119 55.559 4.824 00 32.66 C

ATOM 1035 C LEU B 23 37.990 54.799 6..142 00 33.01 C

ATOM 1036 0 LEU B 23 38.799 54.979 7..059 00 33.02 O

ATOM 1037 CB LEU B 23 39.557 55.479 4..311 1.00 31.69 C

ATOM 1038 CG LEU B 23 39.832 55.862 2..851 00 31.92 C

ATOM 1039 CDl LEU B 23 41.324 55.644 2..544 00 31.01 C

ATOM 1040 CD2 LEU B 23 38.968 55.019 1. ,914 00 30.24 C

ATOM 1041 N TYR B 24 36.957 53.958 6.223 00 31.84 N

ATOM 1042 CA TYR B 24 36.651 53.158 7.408 00 30.77 C

ATOM 1043 C TYR B 24 37.390 51.815 7.406 00 30.86 C

ATOM 1044 o TYR B 24 37.290 51.042 6.457 00 30.57 O

ATOM 1045 CB TYR B 24 35.118 52.950 7.489 00 29.83 C

ATOM 1046 CG TYR B 24 34.605 51.982 8.548 1.00 28.06 C

ATOM 1047 CDl TYR B 24 34.689 50.601 8.359 1.00 29.06 C

ATOM 1048 CD2 TYR B 24 34.010 52.447 9.728 1.00 27.71 C

ATOM 1049 CEl TYR B 24 34.191 49.701 9.314 1.00 28.51 C

ATOM 1050 CE2 TYR B 24 33.509 51.559 10.691 1.00 27.43 C

ATOM 1051 CZ TYR B 24 33.601 50.184 10.475 1.00 29.33 C

ATOM 1052 OH TYR B 24 33.092 49.285 11.398 1.00 29.90 O

ATOM 1053 N CYS B 25 38.135 51.537 8.471 1.00 30.52 N u

ιι) H M oooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H d d H rH d H d d H H r-I H H H H H d H H H H H H H H H H H rl d H H H d H d H H H H H H H r• '* w « lnoo ι ιn

(D lJlo

"l' -l co p- co σ> H H H H H H aOaO OasOaOaO < < ft rt < ft

oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooσoooooooooooooooooooooooooooooooooooooooooσoooooooooooo

HHH HHHHHHHHHHHHHHdddHHHHHHHHdHHHHHHHHHHHHHddrlHHHHHdHHHHHHHdHHHHHHH

< d ιnΦ m d co

H H d ΦΦ ro

r ror ro( ^"»^'^'r'r"- ^ιnιnιnιnιθιnιnι ιθιncccDiDiocococDr~ι^r~c~r~r~ r~r~oooooocoo^ f i ioooi fO oiorococ roMc i roc r rococor c i c roroc rop cooirororo

vιo (Da) H H d rl BB sB ft ft ft fC ft 't fi

Table 3

ATOM 1186 ODl ASP B 41 45.810 59.094 15.981 1.00 47.24 O

ATOM 1187 OD2 ASP B 41 45.073 59.188 13.916 1.00 46.74 O

ATOM 1188 N GLY B 42 44.128 56.143 13.553 1.00 45.79 N

ATOM 1189 CA GLY B 42 42.707 55.956 13.333 1.00 45.89 C

ATOM 1190 C GLY B 42 41.901 56.424 14.527 00 46.60 C

ATOM 1191 o GLY B 42 42.416 56.488 15.644 00 46.61 O

ATOM 1192 N VAL B 43 40.643 56.774 14.286 00 47.12 N

ATOM 1193 CA VAL B 43 39.735 57.224 15.336 00 47.40 C

ATOM 1194 C VAL B 43 38.317 56.844 14.975 00 48.03 C

ATOM 1195 o VAL B 43 37.985 56.718 13.795 00 48.35 O

ATOM 1196 CB VAL B 43 39.767 58.745 15.542 1.00 47.09 C

ATOM 1197 CGI VAL B 43 40.850 59.099 16.524 00 47.34 C

ATOM 1198 CG2 VAL B 43 39.976 59.452 14.219 00 45.89 c

ATOM 1199 N ARG B 44 37.480 56.684 15.991 00 48.67 N

ATOM 1200 CA ARG B 44 36.099 56.291 15.776 00 49.72 C

ATOM 1201 C ARG B 44 35.109 57.447 15.655 00 50.61 C

ATOM 1202 o ARG B 44 34.020 57.274 15.110 1.00 50.99 O

ATOM 1203 CB ARG B 44 35.671 55.316 16.879 1.00 49.25 C

ATOM 1204 CG ARG B 44 36.431 53.989 16.811 1.00 49.05 C

ATOM 1205 CD ARG B 44 36.035 53.017 17.909 1.00 48.64 C

ATOM 1206 NE ARG B 44 36.670 51.714 17.715 00 49.15 N

ATOM 1207 CZ ARG B 44 37.108 50.942 18.706 00 49.17 C

ATOM 1208 NHl ARG B 44 36.982 51.347 19.965 00 49.60 N

ATOM 1209 NH2 ARG B 44 37.671 49.768 18.443 00 48.11 N

ATOM 1210 N GLU B 45 35.487 58.628 16.129 00 51.32 N

ATOM 1211 CA GLU B 45 34.590 59.770 16.061 00 52.99 C

ATOM 1212 C GLU B 45 34.382 60.301 14.639 00 53.72 C

ATOM 1213 o GLU B 45 35.247 60.970 14.067 00 53.64 O

ATOM 1214 CB GLU B 45 35.094 60.885 16.981 00 54.62 C

ATOM 1215 CG GLU B 45 34.103 62.022 17.153 00 56.11 C

ATOM 1216 CD GLU B 45 32.668 61.533 17.166 00 57.20 C TOM 1217 OEl GLU B 45 32.367 60.568 17.904 00 58.01 O

ATOM 1218 OE2 GLU B 45 31.838 62.115 16.436 1.00 57.95 O

ATOM 1219 N LYS B 46 33.212 60.001 14.081 1.00 53.86 N

ATOM 1220 CA LYS B 46 32.863 60.425 12.732 1.00 54.06 C

ATOM 1221 C LYS B 46 32.912 61.941 12.542 1.00 54.13 C

ATOM 1222 0 LYS B 46 32.890 62.429 11.411 00 54.29 O

ATOM 1223 CB LYS B 46 31.465 59.911 12.377 00 53.90 C

ATOM 1224 N SER B 47 32.993 62.682 13.641 00 54.05 N

ATOM 1225 CA SER B 47 33.013 64.142 13.573 00 54.44 C

ATOM 1226 C SER B 47 34.403 64.755 13.425 00 54.13 C

ATOM 1227 0 SER B 47 34.536 65.932 13.092 1.00 54.74 O

ATOM 1228 CB SER B 47 32.328 64.728 14.811 1.00 55.19 C

ATOM 1229 OG SER B 47 32.215 66.138 14.708 1.00 57.49 O

ATOM 1230 N ASP B 48 35.438 63.964 13.668 1.00 53.76 N

ATOM 1231 CA ASP B 48 36.802 64.460 13.560 1.00 53.29 C

ATOM 1232 C ASP B 48 37.058 65.080 12.186 1.00 52.62 C

ATOM 1233 o ASP B 48 36.837 64.444 11.157 1.00 52.61 O

ATOM 1234 CB ASP B 48 37.790 63.320 13.832 1.00 54.05 C

ATOM 1235 CG ASP B 48 39.219 63.808 13.965 1.00 55.08 C

ATOM 1236 ODl ASP B 48 39.994 63.167 14.711 1.00 55.65 O

ATOM 1237 OD2 ASP B 48 39.569 64.825 13.324 1.00 54.58 o

ATOM 1238 N PRO B 49 37.526 66.340 12.158 1.00 52.10 N

ATOM 1239 CA PRO B 49 37.813 67.060 10.910 1.00 50.74 C

ATOM 1240 C PRO B 49 39.037 66.568 10.134 1.00 49.71 C

ATOM 1241 0 PRO B 49 39.256 66.979 8.997 1.00 50.41 o

ATOM 1242 CB PRO B 49 37.962 68.504 11.378 1.00 51.63 C

ATOM 1243 CG PRO B 49 38.574 68.337 12.738 1.00 51.61 C

ATOM 1244 CD PRO B 49 37.745 67.216 13.325 1.00 52.05 C

ATOM 1245 N HIS B 50 39.825 65.685 10.737 1.00 48.05 N

ATOM 1246 CA HIS B 50 41.026 65.163 10.088 1.00 46.32 C

ATOM 1247 C HIS B 50 40.866 63.790 9.411 1.00 44.99 C

ATOM 1248 o HIS B 50 41.856 63.141 9.085 1.00 44.20 o

ATOM 1249 CB HIS B 50 42.173 65.102 11.104 1.00 46.22 C

ATOM 1250 N ILE B 51 39.628 63.344 9.209 1.00 43.86 N

ATOM 1251 CA ILE B 51 39.394 62.066 8.544 1.00 42.57 C Table 3

ATOM 1252 C ILE B 51 38.772 62.280 7.163 00 41.66 C

ATOM 1253 o ILE B 51 38.504 61.316 6.441 ,00 40.77 O

ATOM 1254 CB ILE B 51 38.477 61.141 9.371 ,00 42.29 C

ATOM 1255 CGI ILE B 51 37.116 61.801 9.584 00 42.59 c

ATOM 1256 CG2 ILE B 51 39.148 60.807 10.695 00 42.29 c

ATOM 1257 CDl ILE B 51 36.040 60.839 10.067 00 44.12 c

ATOM 1258 N LYS B 52 38.536 63.542 6.804 ,00 40.51 N

ATOM 1259 CA LYS B 52 37.975 63.871 5.496 ,00 39.40 C

ATOM 1260 C LYS B 52 39.143 63.807 4.521 ,00 38.70 C

ATOM 1261 o LYS B 52 40.060 64.632 4.582 ,00 39.00 O

ATOM 1262 CB LYS B 52 37.360 65.276 5.492 ,00 38.94 c

ATOM 1263 N LEU B 53 39.107 62.824 3.622 00 36.69 N

ATOM 1264 CA LEU B 53 40.179 62.627 2.657 00 34.75 C

ATOM 1265 C LEU B 53 39.783 62.879 1.209 00 34.22 C

ATOM 1266 o LEU B 53 38.610 62.835 0.852 ,00 36.06 O

ATOM 1267 CB LEU B 53 40.710 61.203 .775 00 34.22 C

ATOM 1268 CG LEU B 53 41.174 60.750 .153 ,00 33.71 C

ATOM 1269 CDl LEU B 53 41.431 59.259 ,133 ,00 33.62 C

ATOM 1270 CD2 LEU B 53 42.430 61.507 .533 1.00 34.34 C

ATOM 1271 N GLN B 54 40.778 63.127 .370 1.00 32.84 N

ATOM 1272 CA GLN B 54 40.533 63.363 .044 1.00 31.93 C

ATOM 1273 C GLN B 54 41.373 62.404 .865 1.00 31.30 C

ATOM 1274 o GLN B 54 42.598 62.530 .886 1.00 30.03 O

ATOM 1275 CB GLN B 54 40.916 64.793 .439 1.00 32.97 C

ATOM 1276 CG GLN B 54 40.549 65.155 -2.877 1.00 33.02 C

ATOM 1277 CD GLN B 54 39.042 65.222 -3.080 1.00 34.77 C

ATOM 1278 OEl GLN B 54 38.352 66.036 -2.455 1.00 35.07 O

ATOM 1279 NE2 GLN B 54 38.522 64.362 -3.946 1.00 34.98 N

ATOM 1280 N LEU B 55 40.729 61.446 -2.533 1.00 30.73 N

ATOM 1281 CA LEU B 55 41.475 60.498 -3.375 1.00 31.57 C

ATOM 1282 C LEU B 55 41.591 61.069 -4.786 1.00 30.56 C

ATOM 1283 o LEU B 55 40.724 61.818 -5.234 1.00 30.71 O

ATOM 1284 CB LEU B 55 40.783 59.127 -3.430 1.00 32.23 C

ATOM 1285 CG LEU B 55 40.429 58.411 -2.113 1.00 35.23 C

ATOM 1286 CDl LEU B 55 40.135 56.946 -2.398 1.00 34.62 C

ATOM 1287 CD2 LEU B 55 41.576 58.513 118 1.00 34.97 C

ATOM 1288 N GLN B 56 42.666 60.721 482 1.00 30.02 N

ATOM 1289 CA GLN B 56 42.886 61.211 -6.837 1.00 29.32 C

ATOM 1290 C GLN B 56 43.742 60.202 -7.575 1.00 29.63 C

ATOM 1291 o GLN B 56 44.809 59.829 -7.094 1.00 29.46 O

ATOM 1292 CB GLN B 56 43.597 62.579 -6.789 1.00 29.41 C

ATOM 1293 CG GLN B 56 43.917 63.203 -8.146 1.00 29.62 c

ATOM 1294 CD GLN B 56 42.684 63.475 -8.982 1.00 28.94 c

ATOM 1295 OEl GLN B 56 41.830 64.275 -8.611 1.00 29.99 o

ATOM 1296 NE2 GLN B 56 42.583 62.799 -10.122 1.00 30.33 N

ATOM 1297 N ALA B 57 43.272 59.749 -8.733 1.00 29.97 N

ATOM 1298 CA ALA B 57 44.016 58.779 -9.534 1.00 30.63 C

ATOM 1299 C ALA B 57 45.177 59.458 -10.267 1.00 31.45 c

ATOM 1300 o ALA B 57 45.013 60.545 -10.821 1.00 31.11 o

ATOM 1301 CB ALA B 57 43.082 58.116 -10.545 1.00 29.39 c

ATOM 1302 N GLU B 58 46.342 58.816 -10.262 1.00 32.00 N

ATOM 1303 CA GLU B 58 47.521 59.361 -10.935 1.00 32.70 C

ATOM 1304 C GLU B 58 47.660 58.627 -12.267 1.00 33.16 C

ATOM 1305 o GLU B 58 48.173 59.169 -13.249 00 32.46 O

ATOM 1306 CB GLU B 58 48.769 59.141 -10.075 00 34.03 C

ATOM 1307 CG GLU B 58 49.957 60.027 -10.445 00 35.07 C

ATOM 1308 CD GLU B 58 49.636 61.517 -10.331 00 36.28 C

ATOM 1309 OEl GLU B 58 48.984 61.930 -9.346 00 36.31 o

ATOM 1310 OE2 GLU B 58 50.041 62.280 -11.231 1.00 38.59 o

ATOM 1311 N GLU B 59 47.221 57.372 -12.264 1.00 33.20 N

ATOM 1312 CA GLU B 59 47.200 56.526 -13.450 1.00 34.42 C

ATOM 1313 C GLU B 59 46.210 55.405 -13.136 1.00 33.04 C

ATOM 1314 o GLU B 59 45.739 55.293 -12.004 1.00 32.98 O

ATOM 1315 CB GLU B 59 48.591 55.983 -13.806 1.00 36.51 C

ATOM 1316 CG GLU B 59 49.109 54.811 -12.999 1.00 40.45 C

ATOM 1317 CD GLU B 59 50.435 54.299 -13.555 1.00 42.69 C oozocjoou u zυzz zooozoo ou c υzu c oo υ o zυ u o u o zo u o υ cj o o z u o oo cj υ oz zo cj oz u u o ocj u z

(M ιn lfl ^ w ω β 'l^| H r- m ^ (Iι » « "» ln ω n "^ Ol o ^ ^ Φ Λ ^ o cι ιΛ ^l H ln ncJ H» O H ^ _ o « CD Oo (MΦ αI OΦ l^l n o (M ιn eo d O O ln «^ < («) I^ H O ")^, (M t^ ( O lθ π θ ^^, Φ ^^, ^ O CO ( Φ ^^, "3^, [^ "lO I^ [^ Φ Ol r^ l/ (M l H OO lΛ ^ MM C H P^,ϊ ιn (N] l^ϊl ιn H Φ Φ O CO CO lO ^ OO H H O O ιn

^ r c Csj o o f ιn r^ H M "- <^ co oD θo r^ t^ co r^ r^ t^ r^ co D r* v- ι ιθ 'r cD c^ t^ r^ t^ cD r^ ^ o σ^ co c_ σ^ J ^ ι ι ιθ ι^

"» 'T ro rO (O IO < rO (^ ' "y «, '» CM CM CM CM g CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM f CM CM CM Cg ^ ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooσooooooooooooooooooooooooooooooo

(Λ ϊi o i n r- in ω o c CDO n( cσni tCMM n'*' ωa) OO ιr> CD CO H O O rO O CD O [~ 'r ιO O <M _ CM H H H H rθ tM C CO l_i 'I^, CD l- 'r H C lΛ σ cθ 'Ji '|i VD ιr) lO O t^ CO d O ιr) OO H d H n pι ι/) θ ^ Mθ r- ("M' d-^, -i^Λn "θ Λ"' ^jH H θ d θθ (M ( oι r- m « d d i»i (!i M^ι <Ji M « (n i») H θθ h ^ n d ( !Λ oo oι ω ι»m o ι ιn ιn oo Φ v r" θ r. o ιn Φ σi H σi Mn N i in io H n _ ιn ιn ln ^ ^ H O (^ ι σl a> c N ^ ιn (M σι<o ol (») 1^, ^ d oo ι») ^ ^ ι^,) 0 ^" _ t^^ N (M π o H -) ^ (n n o H ^ H Φ r c i co cM CN in m io cD CD r- iO ri o σi oo cn co co co σi oo σi CD CD in in o i' i c M r T 'r H O O O O O H O O O d d o oo o d PK' fi n i m i' fl' n i iM in

HHHHHHHHHHHHHHH I I I | I I I I I I I I I I I I I I I I I I I I I I I I

I I I I I I I I I I I I I I I

ιJlmoooooo ooo oo d d d( N ι l N^ι<M n M m π^^ ι^(η ^ι ^^ ^ "f ^ »ιnιn ιnιn ιn ιnιn ιnΦΦΦΦ ιoΦΦlI!Φ ^ ^ ^ ^ _ ffl(. B ffl (- oo(!^ l ll O _ Φ Φ Φ Φ _ ΦΦΦ Φ Φ . Φ ΦΦΦΦΦ Φ Φ Φ ΦΦΦΦΦΦΦΦΦΦΦ Φ O _ lO 0 φl0 Φ lø ιDlDlO ΦΦΦCP _ lP Φ lC φ φ φ φ φ cQm ωfflωmmmmmmmmmpamcam ωωca Q m m mβ cQ ca m

CD D CJ) CJ⁾ uCJ)uCJ)uCJ)uCJ)uCJ)u_IuCJ)uCJ)o0 <' >< iH >ι j jιJj j j₍j ιj jj _l,₍j jh)ι-««(, ιϊ ι- ωww ι- iιiιa rt ri tf tf tf tf tf <5 5^j ι^j ,j Hq rt rt rt rt rt^ rt rt rt rt rt rtrt rt ωω w ω ω ω .J J

O _⁾ I? ^ ^ ^ flJ rti ^ 3 g U 5 U - > > > > > > > > > > > B W W lθ n n H H H H H H H H _lJ ^ ιJ j Hl ιJ J J tJ t3 IJI (I 3 > > > > > > > n

H CM H IM H CM rl ω ω rt C^Q CD ^Q W N BG W rt rt cαoo o o < CQ D rt o o a ft D U Q U N 5 < CQ O o o z υu o uυ u z uz z z oo o zooooϋu z υoo oou z c u ouo z υ υou υuoz oooυuoo ^{^} O O Z CJ O O O O O Z

Table 3

ATOM 1384 CA SER B 69 42.448 69.632 6.709 1.00 46.56 C TOM 1385 C SER B 69 43.952 69.817 6.842 1.00 46.50 c

ATOM 1386 o SER B 69 44.451 70.938 6.752 1.00 46.70 o

ATOM 1387 CB SER B 69 41.880 69.193 8.062 1.00 47.39 c

ATOM 1388 OG SER B 69 40.546 69.648 8.225 1.00 48.53 o

ATOM 1389 N ALA B 70 44.668 68.717 7.059 1.00 46.13 N

ATOM 1390 CA ALA B 70 46.116 68.768 7.212 1.00 46.16 C

ATOM 1391 C ALA B 70 46.831 69.248 5.946 1.00 46.37 C

ATOM 1392 o ALA B 70 47.985 69.674 6.004 1.00 46.38 o

ATOM 1393 CB ALA B 70 46.641 67.397 7.612 1.00 45.59 c

ATOM 1394 N ASN B 71 46.141 69.181 4.810 1.00 46.18 N

ATOM 1395 CA ASN B 71 46.716 69.580 3.530 1.00 46.20 C

ATOM 1396 C ASN B 71 48.020 68.816 3.275 1.00 45.29 C

ATOM 1397 o ASN B 71 48.998 69.373 2.780 1.00 44.85 o

ATOM 1398 CB ASN B 71 46.967 71.094 3.501 1.00 47.58 C

ATOM 1399 CG ASN B 71 47.420 71.591 2.129 1.00 49.28 c

ATOM 1400 ODl ASN B 71 46.896 71.171 1.090 1.00 50.06 o

ATOM 1401 ND2 ASN B 71 48.388 72.504 2.123 1.00 49.96 N

ATOM 1402 N ARG B 72 48.012 67.531 3.618 1.00 44.62 N

ATOM 1403 CA ARG B 72 49.169 66.654 3.443 1.00 43.83 C

ATOM 1404 C ARG B 72 48.766 65.366 2.719 1.00 43.20 C

ATOM 1405 o ARG B 72 47.586 65.001 2.702 1.00 42.97 o

ATOM 1406 CB ARG B 72 49.764 66.296 4.805 1.00 44.52 C

ATOM 1407 CG ARG B 72 50.427 67.453 5.555 1.00 45.96 C

ATOM 1408 CD ARG B 72 50.762 67.031 6.984 1.00 47.04 C

ATOM 1409 NE ARG B 72 51.594 68.003 7.687 1.00 47.76 N TOM 1410 CZ ARG B 72 52.921 68.062 7.593 1.00 48.23 C

ATOM 1411 NHl ARG B 72 53.575 67.199 6.831 1.00 46.93 N

ATOM 1412 NH2 ARG B 72 53.593 68.996 8.256 1.00 48.72 N

ATOM 1413 N TYR B 73 49.752 64.681 2.134 1.00 41.62 N

ATOM 1414 CA TYR B 73 49.518 63.435 1.401 1.00 40.58 C

ATOM 1415 C TYR B 73 50.020 62.208 2.156 1.00 39.99 C

ATOM 1416 o TYR B 73 51.160 62.185 2.633 1.00 39.66 o

ATOM 1417 CB TYR B 73 50.215 63.446 0.029 1.00 40.09 C

ATOM 1418 CG TYR B 73 49.784 64.535 -0.919 1.00 40.53 C

ATOM 1419 CDl TYR B 73 50.373 65.807 -0.872 1.00 40.88 C

ATOM 1420 CD2 TYR B 73 48.781 64.304 -1.863 1.00 40.46 C

ATOM 1421 CEl TYR B 73 49.971 66.826 -1.747 1.00 40.70 C

ATOM 1422 CE2 TYR B 73 48.368 65.313 -2.739 1.00 40.89 C TOM 1423 CZ TYR B 73 48.966 66.573 -2.673 1.00 40.86 C

ATOM 1424 OH TYR B 73 48.535 67.573 -3.511 1.00 40.19 o

ATOM 1425 N LEU B 74 49.179 61.180 2.244 1.00 38.79 N

ATOM 1426 CA LEU B 74 49.558 59.939 2.919 1.00 37.94 C

ATOM 1427 C LEU B 74 50.758 59.334 2.211 1.00 38.53 C

ATOM 1428 o LEU B 74 50.857 59.391 0.985 1.00 38.81 o

ATOM 1429 CB LEU B 74 48.416 58.926 2.890 1.00 36.70 c

ATOM 1430 CG LEU B 74 48.709 57.584 3.569 1.00 36.84 c

ATOM 1431 CDl LEU B 74 48.555 57.742 5.082 1.00 35.17 c

ATOM 1432 CD2 LEU B 74 47.747 56.508 3.052 1.00 35.08 c

ATOM 1433 N ALA B 75 51.668 58.748 2.981 1.00 39.29 N

ATOM 1434 CA ALA B 75 52.854 58.131 2.402 1.00 40.25 C

ATOM 1435 C ALA B 75 53.373 56.988 3.262 1.00 40.75 C

ATOM 1436 o ALA B 75 53.151 56.962 4.467 1.00 39.83 o

ATOM 1437 CB ALA B 75 53.948 59.180 2.223 1.00 40.32 c

ATOM 1438 N MET B 76 54.047 56.035 2.632 1.00 42.15 N

ATOM 1439 CA MET B 76 54.620 54.920 3.365 1.00 44.74 C

ATOM 1440 C MET B 76 56.129 54.945 3.143 1.00 45.67 C TOM 1441 o MET B 76 56.600 54.917 2.000 1.00 44.81 o

ATOM 1442 CB MET B 76 54.050 53.580 2.898 1.00 45.53 C

ATOM 1443 CG MET B 76 54.433 52.434 3.831 1.00 47.11 C

ATOM 1444 SD MET B 76 54.068 50.811 3.162 1.00 50.36 S

ATOM 1445 CE MET B 76 52.275 50.720 3.489 1.00 49.90 C

ATOM 1446 N LYS B 77 56.873 55.014 4.246 1.00 47.14 N

ATOM 1447 CA LYS B 77 58.335 55.069 4.215 1.00 48.96 C

ATOM 1448 C LYS B 77 58.982 53.702 3.985 1.00 49.89 C

ATOM 1449 o LYS B 77 58.306 52.670 3.990 1.00 50.27 o uzuυoozoυouυoozυυozυuouzcjuocjuuuzoυoυuoozoυoozoυooozoooυzuooυozoooo

_ ιnn Φ ln <l' ln mo ι lΛ H l _Ol t ^ Φιn lOΦn nn ιJιH ^ "^«»o O lnw α)ιη ^ O | lΛ ι^,l"» r• ι^ι <I> ^oo oιnc VH mn oo ι flo cD V'r o HNNn lftlΛιoιι)ιn -p ιn ιn ιn ι/ι ιn ιntnιn*n ι> ιn tn ιo ι/}tπ ιo ιn 'r ιn ιn " "3 'f ' ιn ιn ιn ιθ oooooooooooooooooooσoooooooooooo oooooooooooooooooσooooooooooooooo oooooooooooooooooooooooooooooooooooσoooooooooooooooooooooooooooooo

H H rl H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

co ιD aι mco CO CO o co a) mmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmωmmmmmmmmmmmmmmmmmmm mmmammmm

Λ ⁽- ⁽lι >ι ^ > > C ⁽3 l) lS U D D D D D D D D D D D DD D D D < < < < l. l. l- lt l. B! I» »IO M W I. I,l- l- l. l- J J ₍J J ^ c π-i Hq ^j Hi rt ή rt pg Λ ω ω c-i ω ω ω ω ω ω ω ω c-i M ω c-i W HH HH H^ Hj H^ iuoooortrtrtrtrt

H CM H CM H CM CQ rt CQ rt CQ C5 Q Q ft co rf <n CJ> a a rt nuaa < ca rt cQ rt CQ rt cou rt CQ

CJ Z CJ CJ O O Z O CJ O CJ CJ O O Z cjuozuooυzoυouoυυzuυouooozooocjzuc oc ozcjυoυzoooυozc υoυ fl ln l in in i m in m dd

00 Λ

H d d H rl H H o aooεaooaaoaoaooaaoaoaoaooaaoεoaooεoεoEEooεoεoεεooεεooaoaoEaoaoaoSεεooεoεoεεooεoaEooεoεoεεoεoεooεoεoεεoεoEoSooEoaoεEoεooεoεεoεooεεoεo O rtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrt

oozooououzc uoυooozυoouzouoυcoz-'uooυυoooυzoυoouuoouυzυυouooυoυozuuoo ro

CM δ a o

CΛ

Φ rιrNdωιn^α)«9V( d( in( 9 ddiΛoσi(M θ H(θHHiDθ"»d<Ji"(^|iJιι»ιnc>j ι)θι»)<!inι»)ιnΦ '^,ιιn"i^|ιn inoρ-(^,)ιndθi _l f^"l^|OΦN(M^ OHlJl(MOOvlD^rt lDooo<DP^mo ^_ι^,^dΦ^ιol doo <M on^<ι^|<ι^|oo<n dVOι^,)^ n χι'(M^H lnιΛιΛιlι09 Φ»ιn"»v^<J HH ^lHOfl>H(^o^^mffloΦ Φ^(Dωωoooιnr)n^^"lιvn(ηnn lHHO(n^lMW(η(η9noOHO_ f^^ r'T"*"r"T'r'r'<<^'r"T'jιι ιn_"*^"^<θ'j'c ro( < (θ"q<< rororof ( co<θ'r^"*ror c ( ( <^ oooooooooooooooooooooooooooooooooooooooooooooooooooooσoooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooσoooooooooooo

H ri H H I H H H H H H H H H H H H H H H H H d , ω m Φ N (M d ιn <M ι⁾l π ιfl o o ω ι) in in ui Mn

I I I I I I n o H _ ^ σl m ^ ln m n co m m ln « o β ιn ^ι » H (o oo t o l H oo » ^ N H n (M "l^, ^ <' ιn ιJ lD d "l' "f d ιnH ι v i Λ n o ^^■ l<) O ι^^Λ Ol ιn m ω ι <l^, ^ N ^ ^ ιη ι n o n a) H (n ιnω o m(D ιn « ^ Φ H ιn co d _ ^ ^f d Φ cΛ τr σ ^ ^ ^ Φ ^ι ^ιo d^ d Ol ^ ln ι^ m r• ιo o ^ ⁽M ⁽M ⁽ _ <θ 'τ r~ o co (o o r~ 'r <i) in ιn 'r σ> ιn 'r ' m o 'r o ci M r~ H in cM H H 'r <Λ M in <rι ι~ ιn H θo cD i M io w csi m <M f n o <o r ιn '^ π ιn (M ( O O d O d lIl α) ^ Φ ^ ffl Φ ^ ^ ^ ω ι»ω ω OH ^ Φ v ^ Φ ^ o) l- O lI> o * ι^,l (M n n π Λ ι <n Φ ι d o o oι Ol Ol OO ιJ\ σ) σl σl O O Oι (^ d ιo _ι ιo _> _> co cD _> _> ιn ιo - iθ ιθ ιθ ιo ιo ιo ιn ιn ιπ ιn ιn _ ιn tθ ro

OO OO "P fl lO lO lϊ ιn ι lO ιπ ι lO lΛ lfl Φ Φ Cθ m m DQ mc^Q m m m cQ Q Q Q ∞ cQ m cQ m Qa Q cQ m cQ ffl m Q m mma Q Q Q m nωffi m

►J ω ι_ ω w rt W Bci rc K K W K

>

H CM H CM H CM H CM H CM H CM H CM H CM H CM Dc) rt _ jqou rt _ cQ c>a a rt CQ rt mo < CQ u> a a w w N ft Q o a a w ω N f n tsoai-i-N < m uozoυoooozooooooozυυoozucjoocozuυoυouυoυozυυouoooooozoooooooooυzυooo

εεεεoosaa hooHoHhHoEιotH < < < < < <

Table 3

ATOM 1582 CG GLU B 96 41.360 51.916 .708 1.00 29 44 C

ATOM 1583 CD GLU B 96 40.476 53.138 ,981 1.00 29 62 C

ATOM 1584 OEl GLU B 96 40.222 53.415 .167 1 00 29.90 O

ATOM 1585 OE2 GLU B 96 40.039 53.816 .016 1 00 28.37 O

ATOM 1586 N ARG B 97 42.380 48.634 .996 00 32.72 N

ATOM 1587 CA ARG B 97 41.711 47.423 .470 00 35.12 C

ATOM 1588 C ARG B 97 40.421 47.108 .700 00 34.90 C

ATOM 1589 0 ARG B 97 40.381 47.161 ,475 00 33.69 o

ATOM 1590 CB ARG B 97 42.672 46.229 .336 00 37.75 c

ATOM 1591 CG ARG B 97 42.010 44.860 .501 00 41.93 c

ATOM 1592 CD ARG B 97 41.947 44.440 .962 00 44 56 c

ATOM 1593 NE ARG B 97 43.232 43.919 .422 00 46.30 N

ATOM 1594 CZ ARG B 97 43.788 42.800 .965 00 47.02 C

ATOM 1595 NHl ARG B 97 43.173 42.080 -6.032 1 .00 46, .95 N

ATOM 1596 NH2 ARG B 97 44.959 42.396 -7.446 1 .00 46. .84 N

ATOM 1597 N LEU B 98 39.363 46.795 -5.433 1 .00 35. .86 N

ATOM 1598 CA LEU B 98 38.097 46.407 -4.823 1 .00 35, ,99 C

ATOM 1599 C LEU B 98 38.170 44.881 .716 1 .00 35, .59 C

ATOM 1600 o LEU B 98 38.142 44.190 .729 1 .00 36, .32 O

ATOM 1601 CB LEU B 98 36.927 46.832 .715 1 .00 35, .68 C

ATOM 1602 CG LEU B 98 35.532 46.361 .272 1 .00 36. .69 C

ATOM 1603 CDl LEU B 98 35.289 46.724 .807 1 .00 35. .91 c

ATOM 1604 CD2 LEU B 98 34.474 46.998 .161 1 .00 35. .80 c

ATOM 1605 N GLU B 99 38.294 44.363 .501 1 .00 36. .08 N

ATOM 1606 CA GLU B 99 38.399 42.922 -3.296 1 .00 36, .41 C

ATOM 1607 C GLU B 99 37.056 42.216 -3.459 1 .00 36, .93 C

ATOM 1608 o GLU B 99 35.999 42.853 -3.419 1 .00 34. .85 O

ATOM 1609 CB GLU B 99 38.985 42.640 -1.909 1 .00 36, ,69 C

ATOM 1610 CG GLU B 99 40.353 43.288 -1.679 1 .00 38, ,44 C

ATOM 1611 CD GLU B 99 41.396 42.871 -2.711 1 .00 38. ,96 C

ATOM 1612 OEl GLU B 99 42.465 43.507 -2.752 1 .00 39. .00 O

ATOM 1613 OE2 GLU B 99 41.158 41.912 -3.478 1 .00 39. .79 o

ATOM 1614 N SER B 100 37.109 40.897 -3.639 1 .00 37. .29 N

ATOM 1615 CA SER B 100 35.906 40.089 .827 1 .00 37. .99 C

ATOM 1616 C SER B 100 34.949 40.199 ,642 1 .00 37. .08 C

ATOM 1617 o SER B 100 33.740 39.982 .787 1 .00 37. .34 0

ATOM 1618 CB SER B 100 36.285 38.623 .080 1 .00 37. .81 C

ATOM 1619 OG SER B 100 37.033 38.093 ,000 1 .00 40. .53 O

ATOM 1620 N ASN B 101 35.487 40.554 ,477 1 .0 000 36. .07 N

ATOM 1621 CA ASN B 101 34.680 40.717 -0.269 00 34.55 C

ATOM 1622 C ASN B 101 33.980 42.084 -0.230 00 33.39 C

ATOM 1623 o ASN B 101 33.245 42.387 0.713 00 33.54 O

ATOM 1624 CB ASN B 101 35.563 40.561 .965 00 35.09 C

ATOM 1625 CG ASN B 101 36.845 41.385 .877 00 37.41 C

ATOM 1626 ODl ASN B 101 36.826 42.557 .489 00 35.76 O

ATOM 1627 ND2 ASN B 101 37.970 40.772 .255 00 38.82 N

ATOM 1628 N ASN B 102 34.215 42.893 .261 00 31.93 N

ATOM 1629 CA ASN B 102 33.636 44.228 .395 00 30.66 C

ATOM 1630 C ASN B 102 34.248 45.338 -0.532 00 30.24 C

ATOM 1631 o ASN B 102 33.610 46.376 -0.317 00 28.46 O

ATOM 1632 CB ASN B 102 32.120 44.197 -1.171 00 31.25 C

ATOM 1633 CG ASN B 102 31.344 43.869 -2.442 00 33.02 C

ATOM 1634 ODl ASN B 102 31.813 44.124 -3.558 00 33.52 O

ATOM 1635 ND2 ASN B 102 30.141 43.319 -2.277 00 32.99 N

ATOM 1636 N TYR B 103 35.469 45.112 -0.037 00 28.45 N

ATOM 1637 CA TYR B 103 36.197 46.126 0.742 00 27.56 C

ATOM 1638 C TYR B 103 37.332 46.566 -0.167 00 27.29 C

ATOM 1639 o TYR B 103 37.645 45.865 -1.132 00 26.21 O

ATOM 1640 CB TYR B 103 36.809 45.546 2.015 00 26.19 C

ATOM 1641 CG TYR B 103 35.830 45.340 3.127 1.00 26. 10 C

ATOM 1642 CDl TYR B 103 35.504 46.387 3.986 1.00 25 . 93 C

ATOM 1643 CD2 TYR B 103 35.239 44.087 3.345 1. 00 25. 66 C

ATOM 1644 CEl TYR B 103 34.627 46.199 5.031 1. 00 25 . 67 C

ATOM 1645 CE2 TYR B 103 34.355 43.891 4.393 1.00 25 . 55 C

ATOM 1646 CZ TYR B 103 34.056 44.951 5.232 1 .00 25 . 68 C

ATOM 1647 OH TYR B 103 33.180 44.781 6.276 1.00 26. 38 O Table 3

ATOM 1648 N ASN B 104 37.940 47.714 0.131 1.00 26.26 N

ATOM 1649 CA ASN B 104 39.053 48.213 -0.672 1.00 26.34 C

ATOM 1650 C ASN B 104 40.394 47.962 0.026 1.00 25.99 C

ATOM 1651 o ASN B 104 40.455 47.867 1.254 1.00 26.46 o

ATOM 1652 CB ASN B 104 38.926 49.726 -0.890 1.00 27.44 C

ATOM 16-53 CG ASN B 104 37.931 50.098 -1.986 1.00 28.73 C

ATOM 1654 ODl ASN B 104 37.230 49.240 -2.548 1.00 25.88 o

ATOM 1655 ND2 ASN B 104 37.869 51.392 -2.293 1.00 26.81 N

ATOM 1656 N THR B 105 41.462 47.849 -0.758 1.00 25.14 N

ATOM 1657 CA THR B 105 42.812 47.708 -0.201 1.00 25.17 C

ATOM 1658 C THR B 105 43.709 48.719 -0.924 1.00 25.62 C

ATOM 1659 o THR B 105 43.472 49.055 -2.086 1.00 24.52 o

ATOM 1660 CB THR B 105 43.430 46.315 -0.422 1.00 24.00 C

ATOM 1661 OG1 THR B 105 43.387 46.005 -1.815 1.00 22.68 o

ATOM 1662 CG2 THR B 105 42.709 45.256 0.405 1.00 24.52 C

ATOM 1663 N TYR B 106 44.730 49.200 -0.226 1.00 26.51 N

ATOM 1664 CA TYR B 106 45.665 50.176 -0.776 1.00 28.14 C

ATOM 1665 C TYR B 106 47.093 49.648 -0.605 1.00 29.96 C

ATOM 1666 o TYR B 106 47.626 49.593 0.506 1.00 28.79 o

ATOM 1667 CB TYR B 106 45.468 51.518 -0.059 1.00 27.28 C

ATOM 1668 CG TYR B 106 44.113 52.112 -0.362 1.00 25.83 C

ATOM 1669 CDl TYR B 106 43.872 52.753 -1.585 1.00 25.32 C

ATOM 1670 CD2 TYR B 106 43.039 51.929 0.508 1.00 25.16 C

ATOM 1671 CEl TYR B 106 42.587 53.187 -1.937 1.00 26.20 C

ATOM 1672 CE2 TYR B 106 41.742 52.355 0.167 1.00 24.66 C

ATOM 1673 CZ TYR B 106 41.524 52.976 -1.055 1.00 25.22 C

ATOM 1674 OH TYR B 106 40.243 53.336 -1.428 1.00 24.70 o

ATOM 1675 N ARG B 107 47.686 49.241 -1.723 1.00 31.88 N

ATOM 1676 CA ARG B 107 49.032 48.673 -1.744 1.00 34.65 C

ATOM 1677 C ARG B 107 50.066 49.651 -2.341 1.00 34.73 C

ATOM 1678 o ARG B 107 49.866 50.185 -3.429 1.00 33.56 o

ATOM 1679 CB ARG B 107 48.983 47.365 -2.550 1.00 35.15 C

ATOM 1680 CG ARG B 107 50.231 46.500 -2.494 1.00 35.99 C

ATOM 1681 CD ARG B 107 49.960 45.150 -3.142 1.00 36.01 C

ATOM 1682 NE ARG B 107 49.470 45.273 -4.514 1.00 36.49 N

ATOM 1683 CZ ARG B 107 50.233 45.574 -5.560 1.00 37.81 C

ATOM 1684 NHl ARG B 107 51.536 45.782 -5.395 1.00 39.30 N

ATOM 1685 NH2 ARG B 107 49.698 45.681 -6.774 1.00 37.32 N

ATOM 1686 N SER B 108 51.161 49.866 -1.614 1.00 36.73 N

ATOM 1687 CA SER B 108 52.238 50.779 -2.024 1.00 37.70 C

ATOM 1688 C SER B 108 52.788 50.470 -3.410 1.00 38.57 C

ATOM 1689 o SER B 108 53.150 49.327 -3.698 1.00 38.27 o

ATOM 1690 CB SER B 108 53.383 50.725 -1.001 1.00 38.05 C

ATOM 1691 OG SER B 108 54.424 51.648 -1.302 1.00 39.50 o

ATOM 1692 N ARG B 109 52.853 51.482 -4.278 1.00 39.46 N

ATOM 1693 CA ARG B 109 53.392 51.241 -5.608 1.00 40.70 C

ATOM 1694 C ARG B 109 54.917 51.140 -5.551 1.00 41.47 C

ATOM 1695 o ARG B 109 55.534 50.547 -6.434 1.00 41.17 o

ATOM 1696 CB ARG B 109 52.987 52.334 -6.595 1.00 41.24 C

ATOM 1697 CG ARG B 109 53.367 51.964 -8.020 1.00 43.16 C

ATOM 1698 CD ARG B 109 52.808 52.923 -9.043 1.00 45.10 C

ATOM 1699 NE ARG B 109 53.312 54.279 -8.854 1.00 47.60 N

ATOM 1700 CZ ARG B 109 53.086 55.279 -9.702 1.00 49.05 C

ATOM 1701 NHl ARG B 109 52.363 55.065 -10.797 1.00 50.36 N

ATOM 1702 NH2 ARG B 109 53.575 56.490 -9.459 1.00 49.22 N

ATOM 1703 N LYS B 110 55.513 51.715 -4.507 1.00 42.37 N

ATOM 1704 CA LYS B 110 56.972 51.676 -4.327 1.00 43.78 C

ATOM 1705 C LYS B 110 57.383 50.351 -3.678 1.00 44.19 C

ATOM 1706 o LYS B 110 58.136 49.563 -4.263 1.00 44.41 o

ATOM 1707 CB LYS B 110 57.436 52.843 -3.447 1.00 42.84 C

ATOM 1708 N TYR B 111 56.887 50.124 -2.463 1.00 43.84 N TOM 1709 CA TYR B 111 57.157 48.898 -1.720 1.00 44.25 C

ATOM 1710 C TYR B 111 55.946 48.008 -1.995 1.00 44.80 C

ATOM 1711 o TYR B 111 55.039 47.896 -1.165 1.00 45.25 o

ATOM 1712 CB TYR B 111 57.263 49.210 -0.226 1.00 43.80 C

ATOM 1713 N THR B 112 55.952 47.390 -3.174 1.00 44.95 N "* c υououzυυouozouoozoooυuυouuc ozυoouuuzouoυzυυoυυouzoυoυzυυoυzuc ouou r-. ro CJ

© a β

CΛ

H U "^"fOOr^tMfO^Φ HCDM^ lΦ^c( f^o^*•σ f^^^ιn"^(>^^,Φflo^^,σlOO( ^^ΦHιΛιn ^^ιc Moσlσ^ fι^ιn"ro Hιn ooHHσ^^(]ooo(^,^τι^, "^Φ(ntD"rΦΦ"^ιnNNOddMOll)ι^Iιnιn<fOOι^,lOOl^l l OOOι.(I)»l/)α! ιJ^doo^rΦnoflOι Φ (^ι^^dΦιJιOdΦ<Illndι <MOn lnιnlnιn ιn"l'<tι^>)nΦ<n( HO(Λoπω^ooo^a Φo^o moo ln Φn^ιn fflωm<JιooHNOO<>lO(ιι^,)ι»)o^(^,)9<ι^,lOlnwln ^^-^-IO ^"f'r'P'p'i'"ti"P"f"P"i'vv"»"»(θ"fnn ιnιηιηιηιηnn^"r( nnnnΛc nnnnn"*"f'P"j"»"»M"r"j^ ooooooooσoooooooooooooooooooooooooooooooooooσooσσooooooooσoooooooo ooooooooσoooooooooooooooooooooooooooooooooooσooooooo ooooooooooooo

H d H H d d H d H H d d H H H H H H H H H H H H H H H H H H d H H H H rH H H H H H.d H H H H H H H H H H H H H H H H H H H H H rl H H

O Hoo ω φ « n n co oo ro o iNnιn _ '»d(M _ HO Olr- o ιn OI- ΦvN IT) σl H H<Jl oω CM ro

CM CM CM CM CM CM co m c ro ro ro m ιn ιr) ιn m ιn ι ιo m ιr) ι ι coco ιoco co cD co r~ r- r- r- r~ oo co oo co oo oo co co >cncn σι σ> σι oo o o o H H H H H H H

HHHHHHHHHHHdHHHHHHHHHHHHHHHHHHHH ' -^ -^{• •} — ' ^CMCMCMC CMCMCMCMCMCM CMCM HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH, 1 H H H H H H H H ' ' mmmmmmmmmm mmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmm mmmmmmmmmmmmmmmmmm tf tf tf Λtf ύPύaSPύeβecaj uciitfcc pή ciapspspήβja coctf xxx x ωuaatttt<*cύaia:β:><>i>i>i>i>i><xxx>ι><r t<< i>3rΑri Uiuuiωaua^

^ H E^H H E^H H OT O W W H E^H E^H E^H E^H H E^H ^ H E^H H E^H E^H E^H ^ > > > > > > rt rt rt rt rt Hq Hq ^ H3 J Hq Hl H3 Hq Hl H3 H3 H rt rt rt rt t Q o rt mo rt co zuHuo CuQuC)ol-l ^Qu o3zυυo C CυQQ U ouoυocjzcjuouozυuoc oC-)u(-l ιosi 3 < υCυJ)z rtυυoo mQ f to o a a a rt CQ rt CQ CJ) CJ) ucjououυzoooυzυoouzυo o o o υ f in r- cΛ

H H H H oo r- r- r^» r- r' dHHH H

O 2 _o s„ ε_ ε_ εr

EHoE^HoE^HoE^Hoε_ EHojoaaas E^H EHoEHoHoE^Hoa EHoaε

O EHoEH ft ft ft ft < < ft < < < <

<*> zooozooouzυυouυooυυoozououuuυzzu υoυzoc ozoυoυozυυoυυυυzzυoooo uzuuoz

ooooooooooooooooooooooooooooooσoooooooooooooooooσooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H i H H H H H H

ι ^{( (} oι Ol Λ oo o o o o o d d H H C H H d H H H H H H H H H H H H H H H mmmmmmm mmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmm

^ ^ ^ ^ Z Z Z Z Z β rt Cή PS OS p≤ PS P- a pή Oύ ύ O OT CO OT O C D D D O D ^ ^ ^ ^ a pή C Pή P- CΛ

J J J J iJ J iJ iJ iJ ^ ΪM ^ ^ tiH ^ rw ^ ^ ϊHi ^ jH ^ ^ ^ jM jH ^ ^ lM ^ iy H ω w w

CJ) O O CJ⁾ CJ) ) O O ) EH EH H H H EH H EH EH EH H EH I-1 IJ HH H3 HH HJ J H3 H3 H^ H1 3 J I-I O O O CJ) OT W C0 OT C OT

H CM H CM

< ft rt muDDWHNϊ ft moDWN rt CQ rt rt m - rt to u a ω N rt Qo s rt zoυozυooυzυoooυυcjucjc ozcjuocjc uozz uυoc zc oozc ooc ozυcjoooυozzocjoooozυυoz

Table 3

ATOM 1846 CA PRO B 132 46.598 40.031 1.729 1.00 51.12 c

ATOM 1847 C PRO B 132 45.353 39.484 2.429 1.00 51.40 c

ATOM 1848 o PRO B 132 44.229 39.882 2.090 1.00 52.15 o

ATOM 1849 CB PRO B 132 46.946 39.262 0.448 1.00 51.15 c

ATOM 1850 CG PRO B 132 48.128 38.453 0.826 1.00 50.96 c

ATOM 1851 CD PRO B 132 48.924 39.390 1.684 1.00 50.86 c

ATOM 1852 N GLY B 133 45.529 38.605 3.408 1.00 50.66 N

ATOM 1853 CA GLY B 133 44.365 38.051 4.078 1.00 49.54 C

ATOM 1854 C GLY B 133 44.015 38.694 5.404 1.00 49.16 c

ATOM 1855 o GLY B 133 43.060 38.275 6.061 1.00 49.29 o

ATOM 1856 N GLN B 134 44.775 39.713 5.800 1.00 48.04 N

ATOM 1857 CA GLN B 134 44.543 40.394 7.072 1.00 45.89 C

ATOM 1858 C GLN B 134 43.307 41.294 7.090 1.00 44.66 C

ATOM 1859 o GLN B 134 42.874 41.813 6.061 1.00 44.65 o

ATOM 1860 CB GLN B 134 45.777 41.230 7.462 1.00 46.36 C

ATOM 1861 CG GLN B 134 47.047 40.425 7.737 1.00 45.77 C

ATOM 1862 CD GLN B 134 48.201 41.282 8.269 1.00 45.99 c

ATOM 1863 OEl GLN B 134 48.006 42.415 8.705 1.00 45.33 o

ATOM 1864 NE2 GLN B 134 49.405 40.725 8.250 1.00 45.77 N

ATOM 1865 N LYS B 135 42.762 41.474 8.287 1.00 42.83 N

ATOM 1866 CA LYS B 135 41.592 42.302 8.531 1.00 41.46 c

ATOM 1867 C LYS B 135 42.004 43.784 8.630 1.00 40.03 C

ATOM 1868 o LYS B 135 41.193 44.689 8.403 1.00 39.14 o

ATOM 1869 CB LYS B 135 40.960 41.825 9.837 1.00 41.75 C

ATOM 1870 CG LYS B 135 39.757 42.577 10.320 1.00 43.82 C

ATOM 1871 CD LYS B 135 39.174 41.833 11.529 1.00 45.84 C

ATOM 1872 CE LYS B 135 38.116 42.655 12.241 1.00 46.02 C

ATOM 1873 NZ LYS B 135 37.055 43.059 11.288 1.00 47.20 N

ATOM 1874 N ALA B 136 43.274 44.014 8.959 1.00 37.66 N

ATOM 1875 CA ALA B 136 43.815 45.360 9.120 1.00 36.75 C

ATOM 1876 C ALA B 136 43.970 46.171 7.824 1.00 34.98 C

ATOM 1877 o ALA B 136 44.069 47.398 7.880 1.00 35.66 o

ATOM 1878 CB ALA B 136 45.152 45.287 9.851 1.00 36.88 C

ATOM 1879 N ILE B 137 43.981 45.504 6.670 1.00 32.94 N

ATOM 1880 CA ILE B 137 44.122 46.198 5.389 1.00 31.61 C

ATOM 1881 C ILE B 137 42.798 46.482 4.660 1.00 30.44 C

ATOM 1882 o ILE B 137 42.809 47.069 3.570 1.00 29.05 o

ATOM 1883 CB ILE B 137 45.015 45.402 4.389 1.00 31.44 C

ATOM 1884 CGI ILE B 137 44.243 44.200 3.829 1.00 32.15 C

ATOM 1885 CG2 ILE B 137 46.284 44.901 5.087 1.00 32.82 c

ATOM 1886 CDl ILE B 137 45.055 43.337 2.865 1.00 30.55 c

ATOM 1887 N LEU B 138 41.672 46.081 5.249 1.00 28.88 N

ATOM 1888 CA LEU B 138 40.374 46.272 4.591 1.00 28.50 C

ATOM 1889 C LEU B 138 39.662 47.565 4.957 1.00 27.52 C

ATOM 1890 o LEU B 138 39.334 47.800 6.122 1.00 27.00 o

ATOM 1891 CB LEU B 138 39.466 45.067 4.874 1.00 26.78 C

ATOM 1892 CG LEU B 138 40.140 43.738 4.484 1.00 27.13 C

ATOM 1893 CDl LEU B 138 39.256 42.552 4.855 1.00 27.13 C

ATOM 1894 CD2 LEU B 138 40.417 43.722 2.990 1.00 25.65 C

ATOM 1895 N PHE B 139 39.433 48.407 3.950 1.00 26.87 N

ATOM 1896 CA PHE B 139 38.753 49.683 4.162 1.00 26.76 C

ATOM 1897 C PHE B 139 37.482 49.836 3.318 1.00 27.04 C

ATOM 1898 o PHE B 139 37.370 49.311 2.210 1.00 26.13 o

ATOM 1899 CB PHE B 139 39.686 50.863 3.852 1.00 27.83 C

ATOM 1900 CG PHE B 139 40.900 50.946 4.746 1.00 29.10 C

ATOM 1901 CDl PHE B 139 42.021 50.139 4.513 1.00 28.33 C

ATOM 1902 CD2 PHE B 139 40.917 51.825 5.835 1.00 28.94 C

ATOM 1903 CEl PHE B 139 43.144 50.214 5.363 1.00 28.98 C

ATOM 1904 CE2 PHE B 139 42.033 51.904 6.687 1.00 27.99 C

ATOM 1905 CZ PHE B 139 43.142 51.102 6.453 1.00 27.54 c

ATOM 1906 N LEU B 140 36.536 50.597 3.850 1.00 27.21 N

ATOM 1907 CA LEU B 140 35.287 50.856 3.162 1.00 27.69 C

ATOM 1908 C LEU B 140 35.169 52.353 2.947 1.00 28.23 C

ATOM 1909 o LEU B 140 35.067 53.112 3.910 1.00 29.52 o

ATOM 1910 CB LEU B 140 34.113 50.362 4.017 1.00 27.73 c

ATOM 1911 CG LEU B 140 32.709 50.495 3.427 1.00 28.01 c ooυυoozzuuoooo

CO CO lO ( lO l lO Cθ σι rO O r~ OO H ro o σi co σi r- cD O in 'j' CM CD c σi co r- m ιo r~ co cD c-> m ιθ ιn ιΛ CD n (θ rθ (θ < co r ιo <o co ro ro ro ro ro oooooooooooo oooooooooooooooooooo oooooooooooooooooooooooooooooooo oooooooooooooooooooooooσooooooooo oooooooooooooooooooooooooooooooo

H H H H H , H H H H H H H H , r rH rH ri rH ri •

H in c0 H ir) H r ( 'J^, 'r O CM O CM CM C_ d C0 f0 O m CM 00 CM 0000 C0 r- lD C0 r~ r0 C0 ^• (θ <Λ vo m ι ιθ 'r 'r o ιo co «- oo co ( H H i ' r~ r» co oo H n ιΛ ι «3i ^ ιo ro o ( oo cD o σι cM θ H r- c~ H CD ιn n oo σι CD H VD <o f o σ <Λ r~ co H r o r- vo co r- H n M σι n r- r crι ιn ιr) m oo r~ ιθ H H Co ιo r o cM CD r-- θ H n ιι r~ r- ιn ' H 'r ιo τ ∞ n o ιo τ m σ r~ vo τ co ιn ιo ιn r f co o r~ H θ m σι ιr> ιn σϊ C θ 'r n ^ o) θ (M θ (^,ι ι~ "i' N iji Φ αι i' Mi N « o >» o m Mn ι/ι eo iJi (D H cι ιη M 'r d H d H O O O CM CM CM CM "- T CD CD CM CM C 'J' CM H CO 'r ^i fi n ι 'Ji ^' ( VD ιι <o n m m m d r ι^, C θ o m cΛ co oo m m τ m c H C cn ∞ m ιo r- r— i— co vo I I HHHHHHHHHHHH I I I I HHHHHH I I I HHHHHHH I I I I I I I I I I I I I I I I I I I I I I I I I

H n H i o r m r- oo oo i- CM H H σi ^ σi 'j' H H r- vo oo co H cM co H H CN 'r H CM ( f c-comHoooinor- 'j'moonmr-ncMCDC Or^σic TOomr inH m co H iO 'r r cn ro co H CD io in H 'r cM CD co oo iD co co in fO co m σi 'j σi co cM oo co ciscMinmoocMooncoHr-m Doof cDHHoo oσiHσiHOHioσioooH co o σ C r~ H r H θ oo M oo ι H cD '3 |~ n r- -> CM θ 'r oo r- D ρ- cD θ ~ H o σι Hθom( coσιτooσιroσιon^iHtΛCDιι< Hθt-r~ om'»Hmr-ooo co

_ι o cM τ -r τ τ n c io co ι— -3 iθ "-^« 'r "a ∞ σ o o o H H CM n ^ n <o <o m ιn r co cM H θ H o σι oo r- <Λ σι r~ o r~ σι oo r-- co co m co co m co co - r- t~- r~ co oo o T in m i i m i m in in m m m m i m m i m io vo cD iD CD iD cD co co D co iD co co C C n cO f r CM CM CM CM CM CM CO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rO ro

C θ cD σι cD ' co i-) cD i~ ')" r- cM H in o cr> ^«- m co ro r- H "α' CM cM iθ H H θ H co H θ <o σι -θ f v-> co cD m iD <τi H θ io r~ r- o «3' D θ H cτι co cN σι r~ CM r- ι r ρ- oo (θ o m "3^, ιθ o θ '>' M

CO lO d O CO lD C OO CM in CM H ro σι io co ιτi H CM Co co H θθ f r- vD n σι σι M co r- r^>- σv o t~ CM

CM H m m rO CM in τ ιO CO (M CM f <M CM ri σι O O H d σ> σ> H <M H H C σi OO CO OO CO co oo σι CPι CD θ H θ H CM H CM H H θ H σι σι oo co oo oo r~ vo vo oo r- co <Λ r- m -r) ro ro ro i co co r f c ro i^ ro io f co ro cM r ro ro ro cM CM c ro ro co co cM CM CM CM CM H H rl rl H rM CM CM CM CM CM CM CM CM CM CM H H i-I H H H H H H H H H H H H H

oodHdHddHNf W ^ιc N<M Mr ^ (^<^ι^( "l^,^^,^"^^,"l'ιπι ι lπιOιnΦ Φ Φ ^^^^^^^r-^^coσ>cooo(Dωcocoσ)σι(TlO (nσlιJ\σ^

₄ « Φ « ^ ι_lι _V Φ ι_l, _{9 7} ι_Iι _1lι « _{9 v} W _{9 <l}, _1|, <), 9 _{V V 9 V 7 9 4} « _{9 H rl r}{ H d H d d d H d d d ,

H rHH rHi rHi rH H H H H H H H H H H H H H H H H H H H H H d H H m m p^Q m m m c^Q m s, ffl ω m D- m ^Q C^Q ω m c^Q m m c^Q P3 P, cQ , m m m u o u u o u u υ u o υ u υ o o o u o υ o o o o o o

O D O O O O O O O EH fH EH EH EH EH EH EH S S piJ pS ctj Bi ιn[n nrawwιnιonoιo)iιiwwHM[jwww[ιjtjιoB)«oιntnwoιoιιiιftιθ<(-Λ(i)-ι

H W Λ Λ l- Λ K Λ Λ U ia iil W W W B W WHM Iim B \ X >1 >< >i >i >i \H ri ri ri ri X X X X X X X X X X X >< < >i >< >i >l >< >1 >< VI V> Ui Ul V> U> U) μi^i-αibdihOiliiSSI.SSSSSonunniα H^H)^^^xn:sxa;bi-o<bαιC-bbi-bi_Hi^^j^rij^j<<<ιa;tt;<<

H CM H CM H CM H oo m o a Qoαw m e> < rt CQ < CQ u α α ω ω N tt nuαuti tt CQ U Q c^jozυooouc zoooυocoυzυoooozooocjzυυoo zoυoozouooυυuouozυcjouuc c zzoc ooc o

oaεaεaaaε rtrtrtrtrtrtrtrt

Table 3

ATOM 1978 OD2 ASP C 19 15.288 27.894 -15.737 1.00 37.85 O

ATOM 1979 N PRO C 20 18.326 26.438 -18.990 1.00 35.49 N

ATOM 1980 CA PRO C 20 19.204 26.143 -20.123 1.00 35.29 C TOM 1981 C PRO C 20 19.551 27.448 -20.834 1.00 35.29 C

ATOM 1982 0 PRO C 20 18.855 28.448 -20.668 1.00 34.84 O

ATOM 1983 CB PRO C 20 18.364 25.193 -20.983 ,00 34.82 C

ATOM 1984 CG PRO C 20 16.953 25.511 -20.597 .00 36.19 C

ATOM 1985 CD PRO C 20 17.046 25.713 -19.112 .00 35.72 C

ATOM 1986 N LYS C 21 20.624 27.445 -21.616 ,00 35.72 N

ATOM 1987 CA LYS C 21 21.045 28.660 -22.304 ,00 36.28 C

ATOM 1988 C LYS c 21 21.677 28.399 -23.648 ,00 36.33 C

ATOM 1989 o LYS c 21 22.015 27.265 -23.982 1.00 36.72 O

ATOM 1990 CB LYS c 21 22.065 29.434 -21.454 1.00 37.40 C

ATOM 1991 CG LYS c 21 21.619 29.715 -20.043 1.00 39.17 C

ATOM 1992 CD LYS c 21 22.412 30.816 -19.379 1.00 41.94 C

ATOM 1993 CE LYS c 21 21.957 30.947 -17.932 1.00 43.48 c

ATOM 1994 NZ LYS c 21 20.497 31.251 -17.926 1.00 43.44 N

ATOM 1995 N ARG c 22 21.824 29.465 -24.425 1.00 36.01 N

ATOM 1996 CA ARG c 22 22.498 29.373 -25.708 1.00 36.72 C

ATOM 1997 C ARG c 22 23.820 30.074 -25.415 1.00 35.60 C

ATOM 1998 o ARG c 22 23.848 31.032 -24.642 1.00 35.48 o

ATOM 1999 CB ARG c 22 21.772 30.163 -26.805 1.00 38.56 c

ATOM 2000 CG ARG c 22 20.285 29.887 -27.004 00 41.76 c

ATOM 2001 CD ARG c 22 19.823 30.641 -28.247 00 44.38 c

ATOM 2002 NE ARG c 22 18.376 30.820 -28.357 00 47.15 N

ATOM 2003 CZ ARG c 22 17.491 29.836 -28.488 00 48.90 C

ATOM 2004 NHl ARG c 22 17.887 28.565 -28.519 00 49.62 N

ATOM 2005 NH2 ARG c 22 16.201 30.131 -28.617 00 48.90 N

ATOM 2006 N LEU c 23 24.911 29.592 -25.994 00 34.26 N

ATOM 2007 CA LEU c 23 26.205 30.244 -25.804 1.00 33.19 C

ATOM 2008 C LEU c 23 26.579 30.892 -27.121 1.00 32.28 C

ATOM 2009 o LEU c 23 26.933 30.214 -28.076 1.00 32.68 O

ATOM 2010 CB LEU c 23 27.281 29.238 -25.389 1.00 32.98 C

ATOM 2011 CG LEU c 23 27.159 28.667 -23.974 1.00 34.44 C

ATOM 2012 CDl LEU c 23 28.171 27.550 -23.772 1.00 33.80 C

ATOM 2013 CD2 LEU c 23 27.363 29.788 -22.950 1.00 33.91 C

ATOM 2014 N TYR c 24 26.490 32.214 -27.155 1.00 31.86 N

ATOM 2015 CA TYR c 24 26.794 33.003 -28.334 1.00 31.36 C

ATOM 2016 C TYR c 24 28.282 33.375 -28.397 1.00 31.57 C

ATOM 2017 o TYR c 24 28.843 33.900 -27.436 1.00 32.38 O

ATOM 2018 CB TYR c 24 25.903 34.249 -28.311 1.00 29.63 C

ATOM 2019 CG TYR c 24 26.319 35.366 -29.231 1.00 28.49 C

ATOM 2020 CDl TYR c 24 27.325 36.257 -28.863 1.00 27.87 C

ATOM 2021 CD2 TYR c 24 25.692 35.548 -30.464 1.00 27.27 c

ATOM 2022 CEl TYR c 24 27.698 37.313 -29.697 1.00 26.83 c

ATOM 2023 CE2 TYR c 24 26.056 36.592 -31.304 1.00 27.20 c

ATOM 2024 CZ TYR c 24 27.064 37.475 -30.911 1.00 27.65 c

ATOM 2025 OH TYR c 24 27.433 38.517 -31.732 1.00 26.72 o

ATOM 2026 N CYS c 25 28.918 33.101 -29.530 1.00 31.53 N

ATOM 2027 CA CYS c 25 30.334 33.415 -29.692 1.00 32.33 C

ATOM 2028 C CYS c 25 30.514 34.761 -30.384 1.00 32.74 C

ATOM 2029 o CYS c 25 29.984 34.994 -31.471 1.00 31.68 o

ATOM 2030 CB CYS c 25 31.038 32.319 -30.498 1.00 31.99 c

ATOM 2031 SG CYS c 25 32.835 32.485 -30.543 1.00 31.09 s

ATOM 2032 N LYS c 26 31.263 35.647 -29.735 1.00 33.99 N

ATOM 2033 CA LYS c 26 31.522 36.972 -30.270 1.00 34.44 C

ATOM 2034 C LYS c 26 32.167 36.871 -31.652 1.00 35.28 C

ATOM 2035 o LYS c 26 31.939 37.717 -32.521 1.00 35.06 O

ATOM 2036 CB LYS c 26 32.442 37.759 -29.336 1.00 34.59 C

ATOM 2037 CG LYS c 26 32.498 39.236 -29.715 1.00 35.12 C

ATOM 2038 CD LYS c 26 33.420 40.032 -28.820 1.00 35.53 C

ATOM 2039 CE LYS c 26 33.366 41.500 -29.176 1.00 35.99 c

ATOM 2040 NZ LYS c 26 34.484 42.228 -28.523 1.00 38.19 N

ATOM 2041 N ASN c 27 32.968 35.830 -31.854 1.00 35.47 N

ATOM 2042 CA ASN c 27 33.631 35.631 -33.141 1.00 35.71 C

ATOM 2043 C ASN c 27 32.613 35.163 -34.185 1.00 35.15 C ooooooooooooooooooo ooooooooooooooooooooooooσooooooooσσooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

HHHHHHHHHHHHHHH, Hθd(i^θdΦιnnmdinωmιnιnι moo(MnvιnNMNNHθH_o<ΛHσidιnιnmι oιono*o3NinΦmNiJ\vdωvΦσιro»m θN

9 n«9■l^|lnΦΛΦflm1»»nnNd"l'ιnΦ^ ωι-(M dNddONm ιooιJιoσloo^I)σιιodd ddN(^,)'JιnΦ^^ooooιI)f■(DΦHN( rt r c <^Mrooor <o<oco⁽ororocorocoro(orororo( r ro<o< ro< cororo< cMfOCO(OCMrocMCMCMCMCMrorOf M

I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

^^ ^^a!OI^Dβ)fllιIlιIll!\ooooooooooodd Hddd dHN^lN^ι(Mιι^l(^l(^|lnfflιoπβn^1ι^,lι^,ιn«<^ι««"l^|'!^l»'*ιr)Λ«1ln <MCM MCM<MCMCM <MCvloιjc c c rθ(θrθ(ocor rocorororo< cθ(θ(θrororθ(o<θ( r ( (θ(θc ocom oϋou υooo υoυo υoc^j uu c υ u o u υ uooυo o υυoυoooυooυooou u ouuo u υou cj u ooocj υ u u υυ υo z zz z z < rH >< < H H H < wH cd H w w ω ωω ω ω i-i ω ω ωω ω ωωω ww w co pjj .j .^ .jjH^ J E K ffi B K -e s M -c s -a s ffi iE ^ rt rtrtrt rt _ (j j) ) θc) o ciι ij &ι « αι C-ι Λ i-< cij Q< αι i-j α4 θj j M α4α<cι_<c

_ HCM HCM HCMHCM HCM HCM HCM H cQ U ^{Q Q} ft < _ ft H U D ^Q W W N t cQuα α ω ωtsj < CQ CJJ Q Q f co o α ω N sc aα ft CQ U O Q < ooυ o z z c^j o o z c o o z u uooouooυoz ooouυocjυ υc z u υ oo υ υυzo cj ou u υz c^j z zzoooooυuzoc o

o oo O -π r -^lo -π -π π - po - or,©π < ft <

ozυuouuυzυoouuoozuuozcjuoozυυoooozϋυoυooozuoozϋooooozυuocjoozuzzzuυo r- ro J

9 O CΛ

H U oo^o(Λ»ol«HNι^»lΛNιΛ ιωnHιonOH09Φwn^<^n n N no>^ ^|ιfl<ΛβιιΦHHoovo» Φιn^ι ιιβH d»oιflβnΛ_^ι α. ιη{M^ιo^co ιoσl (^d oιndΛαlσl σlOcv](M"^ ιηιn ι ιπ^c HdιnHιΩC^o_^^^(M(D_ιJ^toω(ηιnwNO α^oιn^ιnιM^^ f

^ooHHOOOd(^l(MN"f ^^doo^oa)co^ ^ι >l^,flι^,^9fflι^n^"l^,(^,l"»ιOl f^fl"fιnlnιn Φln 9^ooollJl(DlJ O Nn^l OOO ' ιfiιnιOιnιOιOιΛU">ιOtOιnιntOιOιOιΛt0^ιn^^' 'r'r'r'i'^' 'r'i*"tf^^"a^,'^'r^^'r^'3"*'r^^ oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooσoooooooooooooo

HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH HHHH HHHH

H N n "» ιIl on 9 ⁽ΛO r 'r θ H C θθ ιnnn "» 9 d

CM CM C CM CM CM

¹ V ^« ιO iO ιO LO uo W Vu^Uoo^I/ WυUυuU UυoU UuUuuWuUuU UuUuUuUuυU UυUuUooU UoU UυUυUoUuυUoI)oU UuUouUuUuU UυUuUouUuU UuuU UuoU UυUυUυUυoU UuoU UoϋU UooUϋUoUaU UυoUuU UuUu

9Q 9999 ^ lH fe l« l- fe Λ I- Λ H >H ι >ι O U U . O iH ^ J J J ^j μi Cu ⁽- ⁽- (- 0ι Qι 0t ⁽- H ι >ι ι J J iH hH J J J JJ O U O CS O O O O O O O D D D D -; c; Λ _ c; q; p5 c co g g w g o θ H3 H^ H5 Hi rt rt « ζ ζ rt rt rt rt rt rt rt OT o o w OT

. _, ^{r C} H H CCMM HH CCMM HH CCMM HH CCMM co rt muQ ft m o a a rt . < Q tt (Q U O rt cQoaa rt < mu . rt nuQUHix ft J Z CJ O O O CJ CJ Z CJ U O O CJ O O Z CJ CJ O Z uooozuoouuozuooυυoozc uozoυoυoυzoυooυυzuzzzoυo

oo εo

Table 3

ATOM 2176 CB GLU C 45 19.456 29.157 -37.553 1.00 49.68 c

ATOM 2177 N LYS C 46 19.015 31.095 -34.588 1.00 51.13 N

ATOM 2178 CA LYS C 46 18.563 31.029 -33.203 1.00 51.85 C

ATOM 2179 C LYS C 46 17.496 29.955 -32.975 1.00 52.54 C

ATOM 2180 o LYS C 46 17.197 29.598 -31.837 1.00 52.62 o

ATOM 2181 CB LYS C 46 18.013 32.393 -32.771 1.00 50.92 c

ATOM 2182 N SER C 47 16.940 29.436 -34.062 1.00 53.02 N

ATOM 2183 CA SER C 47 15.893 28.422 -33.998 1.00 53.18 C

ATOM 2184 C SER C 47 16.393 26.980 -33.894 1.00 52.59 C

ATOM 2185 o SER C 47 15.634 26.077 -33.533 1.00 52.38 o

ATOM 2186 CB SER C 47 14.998 28.559 -35.234 1.00 53.53 C

ATOM 2187 OG SER C 47 14.065 27.500 -35.309 1.00 54.44 o

ATOM 2188 N ASP c 48 17.662 26.763 -34.218 1.00 51.97 N

ATOM 2189 CA ASP c 48 18.233 25.422 -34.168 1.00 51.11 C

ATOM 2190 C ASP c 48 18.029 24.762 -32.809 1.00 50.64 C

ATOM 2191 o ASP c 48 18.398 25.322 -31.777 1.00 51.03 o

ATOM 2192 CB ASP c 48 19.725 25.466 -34.493 1.00 50.52 c

ATOM 2193 CG ASP c 48 20.324 24.084 -34.659 1.00 50.05 c

ATOM 2194 ODl ASP c 48 20.996 23.853 -35.684 1.00 50.30 o

ATOM 2195 OD2 ASP c 48 20.123 23.228 -33.773 1.00 49.16 o

ATOM 2196 N PRO c 49 17.436 23.555 -32.794 1.00 50.16 N

ATOM 2197 CA PRO c 49 17.174 22.800 -31.564 1.00 49.31 C

ATOM 2198 C PRO c 49 18.416 22.240 -30.865 1.00 48.74 C

ATOM 2199 o PRO c 49 18.332 21.775 -29.724 1.00 48.49 o

ATOM 2200 CB PRO c 49 16.242 21.685 -32.036 1.00 49.47 c

ATOM 2201 CG PRO c 49 16.703 21.441 -33.442 1.00 49.53 c

ATOM 2202 CD PRO c 49 16.876 22.853 -33.964 1.00 49.76 c

ATOM 2203 N HIS c 50 19.563 22.281 -31.537 1.00 47.05 N

ATOM 2204 CA HIS c 50 20.787 21.755 -30.943 1.00 46.14 C

ATOM 2205 C HIS c 50 21.742 22.788 -30.324 1.00 44.53 C

ATOM 2206 o HIS c 50 22.917 22.493 -30.093 1.00 44.37 o

ATOM 2207 CB HIS c 50 21.525 20.893 -31.972 1.00 46.67 C

ATOM 2208 CG HIS c 50 20.718 19.726 -32.451 1.00 48.02 C

ATOM 2209 ND1 HIS c 50 20.261 18.741 -31.602 1.00 48.41 N

ATOM 2210 CD2 HIS c 50 20.243 19.412 -33.680 1.00 48.11 C

ATOM 2211 CEl HIS c 50 19.537 17.874 -32.285 1.00 48.32 C

ATOM 2212 NE2 HIS c 50 19.510 18.257 -33.548 1.00 48.66 N

ATOM 2213 N ILE c 51 21.237 23.989 -30.052 1.00 42.64 N

ATOM 2214 CA ILE c 51 22.047 25.042 -29.430 1.00 41.45 C

ATOM 2215 C ILE c 51 21.567 25.291 -28.001 1.00 40.92 C

ATOM 2216 o ILE c 51 22.129 26.113 -27.278 1.00 40.64 o

ATOM 2217 CB ILE c 51 21.964 26.382 -30.206 1.00 40.29 C

ATOM 2218 CGI ILE c 51 20.518 26.884 -30.221 1.00 39.12 C

ATOM 2219 CG2 ILE c 51 22.506 26.207 -31.617 1.00 39.60 C

ATOM 2220 CDl ILE c 51 20.303 28.100 -31.071 1.00 37.67 C

ATOM 2221 N LYS c 52 20.508 24.593 -27.604 1.00 40.16 N

ATOM 2222 CA LYS c 52 19.976 24.717 -26.253 1.00 39.24 C

ATOM 2223 C LYS c 52 20.881 23.885 -25.346 1.00 37.79 C

ATOM 2224 o LYS c 52 20.920 22.669 -25.451 1.00 37.86 o

ATOM 2225 CB LYS c 52 18.539 24.200 -26.209 1.00 40.26 C

ATOM 2226 CG LYS c 52 17.954 24.113 -24.812 1.00 42.44 C

ATOM 2227 CD LYS c 52 16.433 24.038 -24.863 1.00 44.69 C

ATOM 2228 CE LYS c 52 15.850 23.890 -23.462 1.00 45.74 C

ATOM 2229 NZ LYS c 52 14.364 23.999 -23.484 1.00 47.05 N

ATOM 2230 N LEU c 53 21.615 24.550 -24.461 1.00 35.96 N

ATOM 2231 CA LEU c 53 22.556 23.865 -23.585 1.00 34.34 C

ATOM 2232 C LEU c 53 22.210 23.958 -22.106 1.00 33.68 C

ATOM 2233 o LEU c 53 21.478 24.845 -21.674 1.00 34.17 o

ATOM 2234 CB LEU c 53 23.958 24.432 -23.815 1.00 33.01 c

ATOM 2235 CG LEU c 53 24.375 24.500 -25.285 1.00 33.28 c

ATOM 2236 CDl LEU c 53 25.676 25.300 -25.446 1.00 31.49 c

ATOM 2237 CD2 LEU c 53 24.518 23.078 -25.826 1.00 32.99 c

ATOM 2238 N GLN c 54 22.748 23.032 -21.328 1.00 32.23 N

ATOM 2239 CA GLN c 54 22.496 23.037 -19.903 1.00 31.29 C

ATOM 2240 C GLN c 54 23.831 23.018 -19.151 1.00 31.12 C

ATOM 2241 o GLN c 54 24.582 22.035 -19.214 1.00 30.63 o ucjυozzouooouozuυoouυozzυoouzuoooocjoozc uououoozυoouoozυzzzooozυuooo

"* _» δ ©

CΛ

H υ (ηHOOd Hdalιη^^HHιnΦι-r•^<<> "»^ιιJ>(M^«ιnιn^c oιlmι»)(M(Ilω^mιIl(D ^NO^^•ιnι^,) lnoooιnoιJιo<^,0(M^< ι Hln-1 a. CJC ΦιnΦmNΦno oιrtHmHOlιJ^Φω^ιm^ιoocoωn( Φn^π(MΦωnΦ^oιMΦHHm(Mσlιnoln<]'v MΦ<^"f HO ωωHOιΛOιn

Od(iniMOdOOdiηp)ιf lJ10IJ10000WOdOdOOOddlMNdnrnNιnCMni»ll\llCIOldθnd(MNHι>(«Olπ'f ιnΦdOICIOI)0)(.CO O(Il cococororooo( ro<ooor c roc r c ro( cor r roc r M ( rorococ roro< o r ( ( ^ ooooooσoooooooooooooooooooooooooooσooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooσoooooo

ro ro O o σι «

^ ^ ^v^ιnιnι l ιnιnιnlnΦlOφ Φ φ^ ^ ^ ι~ ^ ιDooωoococD<B(oωo σlιJι<Λl!^olOlβlιJlOOoooo ooo ooHHHH( N M( (M N in in io in in io -atn in in-o -i io iΛin in in iO -i in io in iO uo in c uuuouυoououoυoc oooooυucjoouucjoouuoouυυuoooooouυuoucjoc c ooc oouuuoυoo -1 Ci: >

H CM H CM H CM H CM H CM H cQ Qωω ft m o a a rt raoaωω m < cQoaωw cQooωw < m o a w N X X ft ft co c_

O O U O Z Z U CJ O U U CJ CJ zocjoc ucjozzoυoozooo uuυoozouoooooozoc oooυzυzzzooozoooυυ ω (Λ O H ι^ι ι«) « ln Φ σi -ι o o o o o o o CM CM CM CM CM CM Csl CM CM CM CM CM CM CM CM C^ CM l CM cM CM CM CM CM CM CM CM CM CM W

CO uzυooυoozuoouozc uoυuuuzc uoυυuc zzuoozuυoooozoooozoooozouoooozzoυoou

X ( o m oooooσooσooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

H v [~ ω v o n π nNMHw « ιnΦ'l'n ro

CM H H H H H H H H H H H ro o ι«) m ιn N ι» Ol ⁽M fl

C0 <"1

!M π n nn (N ^φ D O H. υυυoυooυυcjuuoυouuuoouuc uuuυuouuυoouoυooouoυuuooouucjc cjυouuuuυuooouυ

^^^_*^^^^^^Λ^Λf ΛaiΛaaaawwmmmmmmmmm>*>t>t>t^ ^^^^AtΛtΛeiPiιιi ζ rtrtzzzzzzzzc)cj)c) )cj)c)

>>>>>>>>c^ιn nwM!i⁾HHHHHHHHjιJjjι jjjjoθ- U>>>>>> nconnn(i;rt; ft ft ft < ft < < < < ei < i c^j) rt ω cj) c) ft to cj) rt CQ cj) cj) D ft CQ ^Q W N3 rt rt CQ J) J⁾ ft m ft CQ J) a Q rt Q o

CJ Z O O O CJ U U Z O O O CJ O Z CJ O O CJ U CJ CJ Z CJ O o cj o u u z z υ o o z cj o o c o c z u u o o z CJ J o o υυoυuozz uuoυu

oH toιoE< toιoHoHohohot

oooooooooooooooooooooooooooooooooooooooooooooooσoooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H I H H H H H H H H H

O N ιn <f nH n

_

CM <M <MCM CMCM <M OJ CM CM CM CM CM CM CM CM CM CM CM CM<M CM CM CM CMCM I

ID ro

N m N ^ ra σι ol σ> 9 d m Φ d l "f 'J ln r- ^ ln Φ ID ln ⁽Λ ^! ι ι>lO(M lN <^ι O H l H M lIι O d » ι»l ⁽^| ^[ ^ Λ d o o ι ^^ ln m H ιη o ln ιn ^l' C ⁽M fl^ι H CM os ^ ⁽M m o eo β Φ ^ Φ l oιl σι ιJι ι ⁽n o ^ o oo ^ aι ^ co ω ι») Φ H r• ι«) al H N n ι3l (M ιn o m m oo H r "l^l O H ιn ^ Φ v H ^ H O (M ιn ^^ ln n o to o ^ o >^ r^s ^ ιB d !M eo * (O H "f ιn ⁽ "l^| ^ Ol σl n ln ^ lO ι^,1 n n ^ O H ^ oo co Φ O a) (M o n ιn o N ^ι ι) ^ι ^- ιn co ιo ι~ co o r-- oo m o a3 r~ r-- c- co cD ιn "- <τι o c CM θ H H H oi 'r ιn ιn 'r ιo r~ co σ^ co σι o oι σι θ H C θ ao oo r~ r- CM '>' 'r ιr) 1ⁱ ( CM CM f <M H O θ σι

N N CM CM rj N i (M n ( CM <M CM M N ( CM C ⁽o n n n n (^ n n n n n n n n fo n n t "iⁱ n n ^ "i' 'f "» n ( n ri "i^| 'P "i' "*

CM C M M r r co r r (o ro ( r ι ro o «* -p -P '* 'T 'r « ^ tn ιn ιθιn ιoc^ r- r-- r-- r'- r^ r^ r-* r^ r^ r^ t^ r-- c^,--' r-' r r^ ι t^ r^ r"- t^ r^ r^ r- r^ r r^ r^ r- r-- c^ r^,- r- r^ r^ r r^ t- r-- r- t^ c^ υuc uooυoooυooυooooυuocjuuouooυυoouυuouuuuc uuuoouuoooooocjooooυoυυυou

UOOUQ_di_l-_BlΛ l- _dSoi K _l- _lϋini)!" D D'"'D"'D"'D"D"'D_" 'D- _'rt"rt' -rt"rt"rt"E^H _'E^H' H H H EH H . rE^H..C.O „t .W»„W C OT W .OT.^,O.^D „D D D D „^ „C-i fc - „fe Ci^j Clj P -j. „fe. _^..^...^.. _^ c) -!

3283 W W W M CQ U I-I I-] H3 HJ H3 H3 C-1 C-1 C-1 W W I_I W U] >< >< >H >< >H H >< H < H1 H^

Table 3

ATOM 2440 C ARG C 81 38.295 18.757 -29.922 1.00 49.17 c

ATOM 2441 0 ARG C 81 38.356 18.262 -28.800 1.00 48.55 o

ATOM 2442 CB ARG c 81 39.491 17.518 -31.735 1.00 50.35 c

ATOM 2443 N LEU c 82 37.187 19.306 -30.405 1.00 48.69 N

ATOM 2444 CA LEU c 82 35.960 19.348 -29.613 1.00 48.32 c

ATOM 2445 C LEU c 82 34.941 18.320 -30.099 1.00 48.64 c

ATOM 2446 0 LEU c 82 34.789 18.102 -31.304 1.00 48.30 o

ATOM 2447 CB LEU c 82 35.320 20.743 -29.677 1.00 47.29 c

ATOM 2448 CG LEU c 82 36.026 21.976 -29.098 1.00 47.17 c TOM 2449 CDl LEU c 82 35.140 23.197 -29.319 1.00 46.72 c

ATOM 2450 CD2 LEU c 82 36.298 21.796 -27.612 1.00 46.26 c

ATOM 2451 N LEU c 83 34.250 17.690 -29.154 1.00 48.75 N

ATOM 2452 CA LEU c 83 33.218 16.711 -29.469 1.00 49.23 C

ATOM 2453 C LEU c 83 32.286 16.572 -28.264 1.00 49.29 C

ATOM 2454 o LEU c 83 32.566 17.117 -27.200 1.00 49.90 o

ATOM 2455 CB LEU c 83 33.847 15.365 -29.832 1.00 49.75 c

ATOM 2456 CG LEU c 83 34.608 14.566 -28.775 1.00 50.52 c

ATOM 2457 CDl LEU c 83 33.657 13.956 -27.745. 1.00 50.21 c

ATOM 2458 CD2 LEU c 83 35.369 13.466 -29.495 1.00 51.56 c

ATOM 2459 N ALA c 84 31.175 15.860 -28.434 1.00 49.10 N

ATOM 2460 CA ALA c 84 30.219 15.668 -27.347 1.00 48.92 c

ATOM 2461 C ALA c 84 30.058 14.186 -27.004 1.00 48.88 c

ATOM 2462 o ALA c 84 29.679 13.379 -27.852 1.00 49.38 o

ATOM 2463 CB ALA c 84 28.880 16.277 -27.720 1.00 48.95 c

ATOM 2464 N SER c 85 30.336 13.851 -25.748 1.00 48.54 N

ATOM 2465 CA SER c 85 30.277 12.484 -25.249 1.00 48.57 C

ATOM 2466 C SER c 85 28.951 12.060 -24.619 1.00 48.60 C

ATOM 2467 o SER c 85 28.278 12.852 -23.959 1.00 48.21 o

ATOM 2468 CB SER c 85 31.387 12.281 -24.221 1.00 47.92 c

ATOM 2469 OG SER c 85 31.239 11.031 -23.585 1.00 49.89 o

ATOM 2470 N LYS c 86 28.598 10.793 -24.809 1.00 48.12 N

ATOM 2471 CA LYS c 86 27.371 10.254 -24.247 1.00 47.55 c

ATOM 2472 C LYS c 86 27.507 10.209 -22.728 1.00 47.26 C

ATOM 2473 o LYS c 86 26.563 10.521 -21.997 1.00 47.30 o

ATOM 2474 CB LYS c 86 27.112 8.849 -24.795 1.00 47.10 c

ATOM 2475 N SER c 87 28.690 9.829 -22.258 1.00 46.30 N

ATOM 2476 CA SER c 87 28.941 9.751 -20.826 1.00 46.50 C

ATOM 2477 C SER c 87 30.011 10.757 -20.395 1.00 45.67 C

ATOM 2478 o SER c 87 30.930 11.069 -21.146 1.00 45.37 o

ATOM 2479 CB SER c 87 29.367 8.326 -20.448 1.00 47.59 c

ATOM 2480 OG SER c 87 30.485 7.895 -21.213 1.00 47.94 o

ATOM 2481 N VAL c 88 29.881 11.245 -19.169 1.00 45.08 N

ATOM 2482 CA VAL c 88 30.794 12.226 -18.603 1.00 44.44 C

ATOM 2483 C VAL c 88 32.196 11.683 -18.306 1.00 44.01 C

ATOM 2484 o VAL c 88 32.337 10.651 -17.660 1.00 44.28 o

ATOM 2485 CB VAL c 88 30.198 12.788 -17.293 1.00 44.66 c

ATOM 2486 CGI VAL c 88 31.119 13.850 -16.699 1.00 44.31 c

ATOM 2487 CG2 VAL c 88 28.802 13.350 -17.564 1.00 44.59 c

ATOM 2488 N THR c 89 33.223 12.383 -18.781 1.00 43.00 N

ATOM 2489 CA THR c 89 34.608 11.992 -18.524 1.00 42.40 C

ATOM 2490 C THR c 89 35.357 13.227 -18.034 1.00 41.68 C

ATOM 2491 o THR c 89 34.782 14.309 -17.974 1.00 40.99 o

ATOM 2492 CB THR c 89 35.313 11.464 -19.783 1.00 42.09 C

ATOM 2493 OG1 THR c 89 35.446 12.524 -20.734 1.00 42.86 o

ATOM 2494 CG2 THR c 89 34.519 10.318 -20.400 1.00 42.59 C

ATOM 2495 N ASP c 90 36.633 13.066 -17.689 1.00 41.15 N

ATOM 2496 CA ASP c 90 37.443 14.174 -17.191 1.00 41.02 C

ATOM 2497 C ASP c 90 37.718 15.258 -18.228 1.00 41.00 C

ATOM 2498 o ASP c 90 38.282 16.305 -17.910 1.00 41.60 o TOM 2499 CB ASP c 90 38.776 13.652 -16.628 1.00 40.89 C

ATOM 2500 CG ASP c 90 39.530 12.725 -17.604 1.00 41.99 C

ATOM 2501 ODl ASP c 90 39.161 12.634 -18.802 1.00 40.96 o

ATOM 2502 OD2 ASP c 90 40.515 12.089 -17.162 1.00 40.95 o TOM 2503 N GLU c 91 37.320 15.011 -19.469 1.00 40.62 N

ATOM 2504 CA GLU c 91 37.542 15.989 -20.529 1.00 40.60 C

ATOM 2505 C GLU c 91 36.272 16.810 -20.769 1.00 38.90 C CO oυouoozuuocjcozoυocjoooouυzυυooυuυuυuzocjoucjuuc uuzoooυouoozcjooouuzuzzz

Tf Tf t^ ro CJ o o

H ιnlnn^ooc c «ωΦσlιnω'f ^«^Hι^n «lno^ fflΦ< ιnHιn»ιloσleoιnu^(Iιv(»)n H σ\^^nr" nHf^ Doo c OCMOι( ( 'P ^ Nmoιn o<Jlnιn^Nπoslnd Olo«ooc^ll Odm^ ln fl^ ^ι' lnHoo l|ιnι»ι(IlOHmo<-Φ t^llnHln(Ddr•o^•ID"JM'mo( <^, oooodlJ\N^^ Φ^^ ιΛ'l^| ^ ^ ι-ωmιJl(nl^lP^ι dddd ld(^ld(MNHN(1rιnι^,^"^^ιndN( doOddO(^,) "l^,M'ω^ι^O (M(^ln rθ"^'T'rro^<omr rθf (θror rororθf roroc o f rorocoro c ror c r rocopi(oroco<^( ooooooooooooooooooσoooooooooooooooooσooooooooooo ooooooooooooooooo ooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooo

I rl H H H H H H H H H H , *ιn d H H -t Φ ι H H H I I I

dHHHHd(^l(MC (M( CMπ(*lπ(^τ)(η{η^ηp)^n(^ϊ^^^"rfl^,"r"l^,13'1I'^^,"1^,v^vιΛιOι ιΛιOιnιπιnιΛιnιnΦΦ Φ Φ^ ^^^ ^^ ^^a) c oooυcjcjooυυuoυυuocjc υouocjucjυcjucjuuooooouoυuoouoooυc cjoc υouooc υoc c υcjocj CκljκlικCl<mΛaffiaffiκaκ^

ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

Table 3

ATOM 2572 CA LEU C 98 33.549 36.233 -16.451 1.00 35.58 c

ATOM 2573 C LEU c 98 34.702 37.211 -16.606 1.00 36.26 c

ATOM 2574 o LEU c 98 35.252 37.674 -15.612 1.00 37.23 o

ATOM 2575 CB LEU c 98 32.537 36.816 -15.469 1.00 34.84 c

ATOM 2576 CG LEU c 98 32.101 38.257 -15.784 1.00 36.02 c

ATOM 2577 CDl LEU c 98 31.366 38.301 -17.119 1.00 34.57 c

ATOM 2578 CD2 LEU c 98 31.201 38.782 -14.663 1.00 36.07 c

ATOM 2579 N GLU c 99 35.086 37.514 -17.842 1.00 37.80 N

ATOM 2580 CA GLU c 99 36.204 38.433 -18.084 1.00 38.69 c

ATOM 2581 C GLU c 99 35.808 39.884 -17.844 1.00 39.79 c

ATOM 2582 o GLU c 99 34.619 40.226 -17.785 1.00 39.34 o

ATOM 2583 CB GLU c 99 36.739 38.281 -19.517 1.00 39.78 c

ATOM 2584 CG GLU c 99 37.157 36.852 -19.908 1.00 42.32 c

ATOM 2585 CD GLU c 99 38.473 36.383 -19.275 1.00 44.17 c

ATOM 2586 OEl GLU c 99 38.778 35.171 -19.365 1.00 44.05 o

ATOM 2587 OE2 GLU c 99 39.205 37.216 -18.698 1.00 45.49 o

ATOM 2588 N SER c '100 36.821 40.738 -17.713 1.00 40.51 N

ATOM 2589 CA SER c 100 36.617 42.165 -17.470 1.00 40.62 C

ATOM 2590 C SER c 100 35.794 42.816 -18.572 1.00 39.80 C TOM 2591 o SER c 100 35.152 43.848 -18.353 1.00 41.01 o

ATOM 2592 CB SER c 100 37.971 42.882 -17.356 1.00 42.46 c

ATOM 2593 OG SER c 100 38.653 42.906 -18.603 1.00 43.81 o

ATOM 2594 N ASN c 101 35.821 42.222 -19.763 1.00 38.39 N TOM 2595 CA ASN c 101 35.060 42.740 -20.900 1.00 36.37 C

ATOM 2596 C ASN c 101 33.584 42.307 -20.845 1.00 35.56 C

ATOM 2597 o ASN c 101 32.792 42.648 -21.725 1.00 36.19 o

ATOM 2598 CB ASN c 101 35.683 42.244 -22.210 1.00 37.90 C

ATOM 2599 N ASN c 102 33.237 41.549 -19.810 1.00 33.69 N

ATOM 2600 CA ASN c 102 31.890 41.035 -19.584 1.00 32.91 C

ATOM 2601 C ASN c 102 31.418 39.878 -20.473 1.00 31.53 C

ATOM 2602 o ASN c 102 30.215 39.656 -20.621 1.00 29.70 o

ATOM 2603 CB ASN c 102 30.851 42.162 -19.599 1.00 33.64 C

ATOM 2604 CG ASN c 102 30.685 42.813 -18.231 1.00 35.78 C

ATOM 2605 ODl ASN c 102 30.944 42.182 -17.197 1.00 36.62 o

ATOM 2606 ND2 ASN c 102 30.239 44.072 -18.214 1.00 35.16 N

ATOM 2607 N TYR c 103 32.374 39.156 -21.055 1.00 29.91 N

ATOM 2608 CA TYR c 103 32.090 37.975 -21.870 1.00 29.05 C

ATOM 2609 C TYR c 103 32.597 36.788 -21.031 1.00 28.17 C

ATOM 2610 o TYR c 103 33.392 36.972 -20.113 1.00 28.49 o

ATOM 2611 CB TYR c 103 32.843 38.035 -23.201 1.00 28.04 C

ATOM 2612 CG TYR c 103 32.186 38.901 -24.268 1.00 28.96 C TOM 2613 CDl TYR c 103 31.185 38.385 -25.103 1.00 28.99 C TOM 2614 CD2 TYR c 103 32.568 40.232 -24.450 1.00 28.27 C

ATOM 2615 CEl TYR c 103 30.587 39.175 -26.096 1.00 28.06 C

ATOM 2616 CE2 TYR c 103 31.976 41.027 -25.434 1.00 27.36 C

ATOM 2617 CZ TYR c 103 30.995 40.495 -26.249 1.00 28.17 C

ATOM 2618 OH TYR c 103 30.430 41.280 -27.220 1.00 27.43 o

ATOM 2619 N ASN c 104 32.121 35.584 -21.319 1.00 27.04 N

ATOM 2620 CA ASN c 104 32.556 34.393 -20.583 1.00 26.71 C TOM 2621 C ASN c 104 33.604 33.620 -21.378 1.00 25.89 C

ATOM 2622 o ASN c 104 33.641 33.709 -22.606 1.00 24.27 o

ATOM 2623 CB ASN c 104 31.385 33.436 -20.349 1.00 26.70 C

ATOM 2624 CG ASN c 104 30.573 33.778 -19.126 1.00 27.03 C

ATOM 2625 ODl ASN c 104 30.641 34.883 -18.605 1.00 27.86 o

ATOM 2626 ND2 ASN c 104 29.784 32.817 -18.663 1.00 27.30 N

ATOM 2627 N THR c 105 34.448 32.871 -20.671 1.00 25.77 N

ATOM 2628 CA THR c 105 35.444 32.017 -21.315 1.00 26.79 C

ATOM 2629 C THR c 105 35.374 30.659 -20.626 1.00 27.22 C

ATOM 2630 o THR c 105 35.037 30.568 -19.434 1.00 26.69 o

ATOM 2631 CB THR c 105 36.887 32.561 -21.197 1.00 27.27 C

ATOM 2632 OG1 THR c 105 37.277 32.601 -19.819 1.00 27.69 o

ATOM 2633 CG2 THR c 105 36.988 33.940 -21.817 1.00 26.48 C

ATOM 2634 N TYR c 106 35.683 29.608 -21.383 1.00 27.57 N

ATOM 2635 CA TYR c 106 35.649 28.245 -20.868 1.00 28.53 C

ATOM 2636 C TYR c 106 36.980 27.560 -21.138 1.00 29.84 C

ATOM 2637 o TYR c 106 37.298 27.243 -22.279 1.00 30.42 o oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooσoooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

(<) o d n ro « ro

^t^o ιD ^o ^o^I⁾^oι«^ ^ ^ ^ r-^^ ^^ βolloo!OCDCOl!ι ι^ (ΛιJlιI>(!l « ι^(Il Ol rooooo o oooodH H dri dd N( NNN l l nι<l O O O O O O O O O O O O O O O O O O O OO OOO OO OO O O O O O O O O H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H uoυuυoυuυoooυυouoouoouυuuuuυuooυcjcjuoc ooooυoocjoυouυcjυυououc c c cjuuoc cj cήβ; , , S ,p,p, - o ooouuoo . , ,p,rt« ήθθϋϋθuc5ϋou ) owwwwwc OT

:« ι><>ι:H>H>ι>Htf e£o$tf PSQ5øs<tf $δωωωωωω sPήg

EH EH H EH EH EH EH Λi rt rt rt rt rt rt rt rt rt rt c ω co co OT rt rt rt rt rt rt rt rt rt rt rt J

< i

CO υouozυc ocjuoυzυuuoυzc uoc υυuuuuozououυozυυoϋzυυouυuuzoυooooozzuuouzo ro CM

© © CΛ

S3 υ Hi

PM ooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooo

I H H H H H H H H

9 _ Φ m ω

» ι») -p

nn n n θi(rιmooooθ H H

HHHH HHHCMCMCMCMCMCMCM HHHH HHHHHHHHHH oυcjoυooυoυoυυυυooυυooouυooooouυuoooooooυoouooooooooouooouoooυooυoo

Ctf O- ή Pή l^ O^j l-j Qj lj t^ -i e Cl^j C^j -i fe CU -i ή PS PS pIJ iS pS rt rt c_ ω ω ω o- ι; a: ι_; _; c_ o- oι; pc; a; oc; c p- - H H ι >H H H >< >H H >H H rt rt rt rt rt rt rt

OT W W E^{H H} H E^H H E^H E^H E^{H H} H H E^H H -^H H ^H E^H E^H H E^H E^H H H E^H £^H E^H > > > > > > rt irt rt

H CM H CM C CM Π CM H CM H CM H CM H CM

_ cacj) f ouQQωωι.NNa < n. QQωwnaj t co u> ø f m m o a a < CQ U Q U N t m ft uoυozuuouυoυzuc cjc υzc ooouoooυoozouocjocjzouoozoooυυυυzoυouυuυzzcjoouzu P^ "l^, ιn Φ tD (Il O H (M c«) « ln Φ ^ co ιn o H ^ι (η "» rt Φ ^ -> σl "i^, "» "i' ι» <» i' "«^| ι ιn cn ιn ιn ιn ιn ιn ιn ι Φ Φ Φ Φ Φ Φ [^ [~ t^ c^ r-- [^ r~ r~ r^ r-- r- r~ t^ CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM

EoHoH HooHooH HoHooE"HooHHooE EoHoEH HooHotιoEιohoHoι

oozooo

HΦ oo O( "l' lMN m ooooooooooooooooooooooooσoσooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H - ιn N H O I I I V"f O)0 H ifi σι r~ ^ ^ d ιnln N ι^,ι oιn m m ol ω mmflo ωm om

C M CM CM CM CM CM CM ro

H H H d H<M ^{( (}M⁽ ιo iDθoo (Dco σι m σι σι σiθ o o o

CM CM CM CM CM CM CM CM CM H H H H H H H H H H H H H H H H H H H H H H H H ouυυooooououoυooυuυooυoououcjocjυoouuuooooooυooυυoouuυoocjuouuuuuuouc

QSg ήαSg^ϊw^^zzzzzzzzz ή ήcspήcύ G tf tf ciiBήαpS oc ww

I ϊ M * Ϊ J J J J iH Hl J J ₁J J J _lH i ι >< H >ι ⁽ >ι > ι ^ < < < >ι ι >ι < ι ι ω i- I- ω ω W M I. μi _lH ^ α M H fι t< HO !I O O O - I⁾ 5 50 UO O ι h h h Eι EH tι tι H t< tι J J hH j iH iHiH iH iH iH j j μi ιJJ J J UO C3 U n n

H CM H CM H CM H CM H CM

CQ CJ) < ft CQ CJ) Q W H ft cQuααwωcos- et O U Q H N rt αuαα f ft fflu rt CQ < υoooozυoozoυoocjcjozzcjuo υoooυuoozoυooooozzuooυoυuzc uozuoouozcjuouzυoo nffiO HN in π ω CM oHoEHotoEι Eo<oHotoEH toι FoEoHoEH toιotι toιoHoHoH ft ft ft < < ft < < < < '^:t < < '^:t < < ι^!t ft

υoυzυoozυυoooυzocjozυooocjuozzc uoυuυcjzzυυocjzυυoocjcjυzυuoc c ocjzcjuoc ouυυ

σooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H rH ri rH rH ri

CM

oooυooυυυoouoυυcjocjc υouυcjoυc uoυcjooυuooυυuuuouuooouυuuuυυuuocjouooυoυ ≤-≤-≤^^^^ QQQQSQ^^^^z^szzzzzzOTwc c c o tortrtrtrtrtωωtaωω

E^H E^H H O O O O ^ θ θU & L, Ol - O O O O C_ O ⁾ O C) O O O HH H^ HH HH HH J ^ ^ ^H rt rt rt rt rt H H H H H H H H j

_ M H CM H CM H H CM H CM H

CQ O CJ) ft _ ft CQ U Q rt ft PQ U Q W W < P) . Q dl N rt CQ ft CQ CJ) CJ) Q ft CQ U Q Q CQ O Q Q M υoozc oozυυoouuzoυozc oocjooozzυooυuoυzzϋuouzuυouuuυzuc ocjuuuzυoouuυuo m m ιn ιD Ol O d r c < ro

00 00 CX) CO 0O rH CM CM CM CM aaa aaaε εεaaε εaaaεεεεaεaaaa oooao-ιaooaooaooaooooasooaooaooaooaooaooooaooaaooaooεooaooaooooaaooεooooaoao«-<oao-_oεo. —oεoεoo~εoaao ε o ooo oεooεaoεoaoooooaooaaoooooo OOOOOOOOOOOOOO

O it ft ft t t t f ft t t t ft ft ft ft t t ft ft f t f t t t ft f ft ft ft ft < < < < < < < < < < < < < < f t ft ft r ft t f ft f^ i^ fi ft fC

> _H3 r9 _H3 >_H3 _H3 _H3 _H3 _H3 _H3 _H3 _H3 _H3 _H3 _H3 _H>- >_H3 _H3 _H9 _H- _H3 β H _H3 _H3 MH3 H >H H H _H3 H _H3 _H3 ϊ^» 3H > Ji ϊ» >

O SOSOSOSOSSO OSOSOSSO OSOSOSSO OSOSOSOSOSQSQSOSSO QS5- OsOsOsOsOsOsQsOsQsOsOsQsOsOsOsOsOssOOssOsOOsOsOssOOsOsOsOsOsOsOsOsOsOsOsOsOsOsOsOs

I NI ) M \) M M N N N M M N M M Il) M M N) N I N M M M KI M M N> ll) M I N M M M U U M N N M N M M M NI M M M Ill Kl M I N KJ I Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ ID Φ ID IO Φ Φ Φ Φ Φ Φ Φ ID Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ D Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ . Φ Φ Φ Φ Φ Φ Φ Φ Φ σ σ cr^ σ σ σ <-^ o n n CJl π u^ cπ u^ p CJ n •— - •— . t&. it* _ . ■_. _. !_ . Λ ω cJ ω ω tΛ) ω t) w w ^) ll ^) ^> ) ^) ^ ^) l ) l H r^l r» P r_^{J J l}-^, —

^ m lll ^ UI M H O GO ^ σi Ui ft U M μ O αO ^ Sl lll A U M P O ω vl ai Ul iMil M HO Φ ∞ ^ Ol l ib U IO P O Φ - ^ in Ol Λ U M H O CO s Λ Ul Λ ω M O O O o o o z o o ooo ooo n nzooooz O O O O Z O O O O Z O O O O O O W O O O O Q Z O O O O O O Z O O O O O O O Z O O w α ot > N B BDOOB > CD > CD > CD > CD CD > M σ n D D O H > O O O CD > N M

N H ro lr' |H |H lH |H lH tH p fl lB I_TJ lt lB lfl lfl >lj lfl lH !t a! K Jl! !E |H |H |H |H |H HI κj M: H< κ; H< κ: H< κ; κ aB a. ac 33 a: !_ tE !_! tB 3- H H M H H H< κ; H H< ι ^ j^j jfl ja w π pi K R pϊ M Pi K ai w ω cΛ Λ ω ω cn ω M M Pi Pl Pi W M M lM M W w w w ω ω Λ Co n Λ ω co i ooooαααααcααwM σσoσσoσoσoσσσσσσσσαoooσαoπonoπooooooooooooooπoππooooooπoooπooπoooo ooωooooroαιω ro .J i ~^j>^j ^ ^j v^j i ^j i - oιmm σι (i\ ι oι ι ^ uι ui ι-ι- ι-Λ ι-u ωu uuι⁾ MMM N Mii M H PH p pHθθoo ooo θ Φ

cπ π oi n ϋi cn n cn M U ) M j Λ Λ *. Λ Oι Ul oo i- H-' ιiiϋι _ omω ω*p Uiφ φo αι ui A i]iH uιCD vJ N) H (Il U Φ ) ω ω ω ω u M M M u u u u ωu ω iιi uω ι. iιi c u u u iιi u ω ι>i -i u w u ω u u ω u ω M M

•_. σi -J -J σi -J σi σi cn i-. t- t w n ω ω cπ i-. to M H Ni r' r' iD μ o μ μ o9 Φ Φ Φ θ M i M P N} ~ι uι uι A μ M u ω 6 ^ M < ι>ι ω & o oθ i m « b uι « φ

Φ M O IS l φ b uι cD

- σi o tn i Λ Ui p uι o σi m M ω ω o >ι o o φ

O O U1 d!

oo ooo oooooo ooooooo

ooooooozoooooooooozoonoz oooozooonzooooozoωooooozoooooozooooooozoo

uooocozooo

< PlH lnMn olno OdσllJl O fl or<l CM f CM CM H "a ir) CD _l ro rθ ( co rθ (θ ro c co oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H I rl H H H H H σl m _ ln o σl N M m m ^ N ( N Φ m o ω "i' ian ω Φ d N H v o a! θ "( N iη d iJi 'i' n d oi d θ N m ιnci H in » ιn r o _ ω n ^ π " f i^,) » Φ ( θ iιι ι»ι i θ Φ θ d ω ln ι^,l σl ^ι φ N Φ H H m ιn ^ oι) ^ι d M O ^» o (Iι d o Ol f^ « o o l N ι^,) ^ ^ cι ^ Φ ι <M ^l d ln ^ O f• ^l d Φ ι- o ι^,l <Il Pl » Ol ιΛ (M ^ o p^■ β ) O lΛ oo w d O d Φ (Il Φ ln ω ^ oι w oι) r- o m o d ^ m o oι ^ιl ^ n (M ιΛ ^ "r (O H ω ι» "^ l (<) OJ O H ω ^ _ "» eo "» ιn ιn m C O ^ ιπ « O d m iD ιn ιθ ι ι ') 'r oi ιn co cD ιθ 'j^| r~ r~ r~ ιθ 'r 'r ιn ro f co cM CM c f cM Cj CM r cM M < <» csi co cM M CM ri "»

(M ri N (M <M lM !M (M N W CM N N Cl| (M (M rj N N (M Ci| lM N N CM N N N lM <M N W <M N lM N (M CM (M CM <N N (M (M CM <M H H H H H H H H H H H H H H M <M H H d H ln ω d N N « o (- f oo o <J (- O (O Φ (M O

N "^ n "f ιη H H H "f ln ln "^ "J n (η ^ ^ ω ι_ ^ _ ω ^ ω m m ^ ln "I n n tM H (M ( n fn l ^ r^ N lM w w l < n H n ιM n n ιn Φ ^ ι^ ^^ oo _ ι >n ιn >n ιn ιn Ln n tθ Ln >n ιn n ιn ιn ιn ιn ii in ιπ ιn u) ιn ιn ιn ιn ιn >n ιn ιn >n >n ιfl ι ιπ Φ Φ Φ Φ Φ Φ Φ Φ o Φ Φ Φ

co σi Φ in i^ji i^ji iΛ oi m o o o o o o o d d d d H d d d d N N N N iM ^ N N N N N n n n f n i i'i i'i w ir w fl ^ fl w v v v v ^ i/i in in in in iii Φ Φ Φ H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM ΓM CM CJ CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

^Q D ^{Q Q Q Q Q Q Q Q} D ^{Q Q Q Q Q Q Q} Q Q ^{Q Q} Q Q Q ^Q Q Q Q Q Q Q Q Q Q Q Q Q D D Q Q Q Q Q Q Q Q Q Q Q Q Q Q a Q Q Q Q Q Q Q Q Q Q Q

Λ fe (- lk (- I. Oι (. O O O O O O O W M !θ n n W m t M O O O O U ϋ ϋ (l) O U U D D D D D D D D (< l< (i! l- (ii (il lli (i; (- (i! P505 CO W CO CO CO CO CO C C CO t O C W CO W CO RS S S pS ai BS S ^ ^ ^ ΪH ^ ^ ^ ^ ΪM Cή ή pS ή ή a « ^ H >H >H H H >H >H I H >H

N rt en CJ> a ω N w K ft cooαo ft cooααωc-iN -! ft CQ CD rt z z o c o c uoozυcjoouozcjcjocjuuozzυυoc υcjz —o "z ' zz U U O J O CJ CJ Z CJ CJ O U O O CJ CJ U O O zououcozc υo cooo ισJ>v ( "f ιn ω cn o H< n oo oo CM CM CM CM cscM CM ro ro cor

00 ooθooθ n0n0 r0ιn0 n00rιn0n0 r0ιr0ιr0ι rH rn r m ro ro r ro r r ro ro r r

© εooεoεεoεooεεoaooεosεoεoεo εoaaεε εεaεεaaa εaaaεεasooεoaεoεooεεoεoosaoao o EHo-HoEHoH EoH Eoεε H EoHoHoEHoHoHoH EoHoH Eo εε -J oooaaososoooooooo ft ft < < ft ft ft ft ft ft ft ft < ft < < ft < ft < ft < ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft

CO cjc υυzzououυozzooozυoozc c ooc uoouozcjoocjcjcjc cjc ozc ooc uoc z -'cjocjoυzυzzzc c o

r■ omd H l!l " ιn oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H HH H H H H H HH H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

H '» ω <M ln n md xm odlIι oιIl<ll al alιIl Nfl "f

H H H H CM CM CO l CM rO CM CM CM CM CM r r ro m ro

Φ lO Φ Φ ΦΦ Φ

ι£ιφ ^φφ ^ ^^ ^ r^•^^!oxa⁾a⁾lIιιIι ιIlιJlOoooooooo oo d dd d d ddd (^ι^lN lN lN<Mι^,)nι^«)P)( nπnnnfl<l'fl^ι »^f

CM CM CM CM CM

QQQQQQQQQQQQQQQQQQQQQQQQQQQOQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ _IQQQQ

H CM H CM H CM H CM co > Q ω to ft tooDQ rt rt rt (J O Q D U IiJ N rt c IDo C 13D Q a Q a t w] | wι| NN ft C DQ U o aQ Q Q ft Qoaω E s: rt ocjouzzoυoυoozzouozuuo i CJ CJ O O U O O O O U Z O U O O U O U O O U Z CJ O O CJ U O O zυcjoouυzozzzυυo

CO uc υυzuυoυzυυoυcjuzυυoυc oozυυozoooυυϋzuzzzυυoc uυzuc oc ooozuoozυuouuuz

Hf OH ι*)v σl Hfll H ^ H"]^,^ ^"l^,r^ HOO N O

_OO_OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H H H H H , H H H H H H H ,

ro

<n n ιn H H N

( π

ΦΦ

v w » « ιnιnιn f ι^τ) n (^,l ι^,ln (0 co ro coo m ro ^pi

Q D Q Q Q Q Q D D Q Q Q Q Q Q D Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q O Q Q D Q Q Q Q Q Q Q Q Q Q D Q Q Q Q Q Q a a Q Q Q Q

Iή U 10 » M M ra O OO O OO O fcft lH 0ι fc Λ llι l- >ι ι ^ ι (5O U UU UO U UU CI ιJ J ^ J J J J Λ ft lH Λ & ft ft J J J HH HH U

1-3 H^ H^ H H H H H I-i Oj Cή Cd Pή - O- CO CO W O O O O iJ i-l i-l i-I CCj iJ iS ή pή pi; iriχχχχχ^p*⁽ Pia4C o*r f << fto θf tf < t< >>>>>>>ft<<< << < oo >

Table 3

TOM 3166 CA ARG D 44 59.721 21.504 37.093 1.00 48.22 c

ATOM 3167 C ARG D 44 58.216 21.574 36.810 1.00 49.00 c

ATOM 3168 o ARG D 44 57.660 20.680 36.169 1.00 49.13 0

ATOM 3169 CB ARG D 44 59.947 20.570 38.296 1.00 48.25 c

ATOM 3170 CG ARG D 44 61.396 20.125 38.554 1.00 48.15 c

ATOM 3171 CD ARG D 44 61.425 19.003 39.600 1.00 47.68 c

ATOM 3172 NE ARG D 44 62.689 18.262 39.650 1.00 48.47 N

ATOM 3173 CZ ARG D 44 63.846 18.740 40.112 1.00 48.64 C

ATOM 3174 NHl ARG D 44 63.932 19.977 40.579 1.00 49.00 N

ATOM 3175 NH2 ARG D 44 64.928 17.972 40.109 1.00 49.22 N TOM 3176 N GLU D 45 57.557 22.627 37.289 1.00 49.76 N

ATOM 3177 CA GLU D 45 56.109 22.773 37.106 1.00 50.30 C

ATOM 3178 C GLU D 45 55.680 23.011 35.656 1.00 50.71 c

ATOM 3179 o GLU D 45 55.824 24.112 35.121 1.00 50.47 0 TOM 3180 CB GLU D 45 55.577 23.905 37.987 1.00 49.49 c

ATOM 3181 N LYS D 46 55.135 21.970 35.036 1.00 51.11 N

ATOM 3182 CA LYS D 46 54.685 22.040 33.652 1.00 51.83 C

ATOM 3183 C LYS D 46 53.616 23.116 33.430 1.00 52.71 C

ATOM 3184 o LYS D 46 53.309 23.470 32.289 1.00 52.71 0

ATOM 3185 CB LYS D 46 54.140 20.677 33.219 1.00 50.96 C

ATOM 3186 N SER D 47 53.057 23.641 34.517 1.00 53.19 N

ATOM 3187 CA SER D 47 52.015 24.657 34.418 1.00 53.48 C

ATOM 3188 C SER D 47 52.522 26.092 34.336 1.00 52.94 C

ATOM 3189 o SER D 47 51.762 26.996 33.983 1.00 52.87 0

ATOM 3190 CB SER D 47 51.048 24.543 35.601 1.00 54.05 C

ATOM 3191 OG SER D 47 51.734 24.698 36.833 1.00 56.01 0

ATOM 3192 N ASP D 48 53.794 26.310 34.664 1.00 52.50 N TOM 3193 CA ASP D 48 54.362 27.657 34.621 1.00 51.66 C

ATOM 3194 C ASP D 48 54.161 28.310 33.254 1.00 50.90 C

ATOM 3195 o ASP D 48 54.530 27.745 32.223 1.00 50.75 o

ATOM 3196 CB ASP D 48 55.858 27.629 34.961 1.00 51.83 C

ATOM 3197 N PRO D 49 53.567 29.516 33.232 1.00 50.14 N

ATOM 3198 CA PRO D 49 53.306 30.263 31.996 1.00 49.15 C

ATOM 3199 C PRO D 49 54.550 30.820 31.305 1.00 48.42 c

ATOM 3200 o PRO D 49 54.472 31.288 30.167 1.00 48.13 o

ATOM 3201 CB PRO D 49 52.373 31.380 32.457 1.00 49.52 c

ATOM 3202 CG PRO D 49 52.857 31.657 33.855 1.00 49.18 c

ATOM 3203 CD PRO D 49 53.052 30.251 34.406 1.00 50.05 c

ATOM 3204 N HIS D 50 55.696 30.773 31.981 1.00 46.75 N

ATOM 3205 CA HIS D 50 56.916 31.304 31.383 1.00 45.88 c

ATOM 3206 C HIS D 50 57.874 30.272 30.765 1.00 44.34 c

ATOM 3207 o HIS D 50 59.045 30.570 30.528 1.00 44.23 o

ATOM 3208 CB HIS D 50 57.638 32.185 32.405 1.00 45.79 c

ATOM 3209 CG HIS D 50 56.829 33.371 32.833 1.00 47.26 c

ATOM 3210 ND1 HIS D 50 56.501 34.395 31.970 1.00 47.30 N

ATOM 3211 CD2 HIS D 50 56.213 33.657 34.005 1.00 47.36 C TOM 3212 CEl HIS D 50 55.715 35.257 32.589 1.00 47.33 C

ATOM 3213 NE2 HIS D 50 55.525 34.833 33.824 1.00 47.72 N

ATOM 3214 N ILE D 51 57.370 29.068 30.499 1.00 42.18 N

ATOM 3215 CA ILE D 51 58.177 28.016 29.871 1.00 41.06 C

ATOM 3216 C ILE D 51 57.698 27.771 28.442 1.00 40.46 C

ATOM 3217 o ILE D 51 58.264 26.950 27.721 1.00 40.26 o

ATOM 3218 CB ILE D 51 58.097 26.665 30.636 1.00 39.75 C

ATOM 3219 CGI ILE D 51 56.647 26.181 30.697 1.00 38.79 c

ATOM 3220 CG2 ILE D 51 58.675 26.818 32.030 1.00 38.97 c TOM 3221 CDl ILE D 51 56.457 24.914 31.485 1.00 37.44 c

ATOM 3222 N LYS D 52 56.639 28.471 28.043 1.00 39.78 N

ATOM 3223 CA LYS D 52 56.103 28.345 26.691 1.00 38.80 c

ATOM 3224 C LYS D 52 56.999 29.181 25.783 1.00 37.62 c

ATOM 3225 o LYS D 52 57.023 30.399 25.881 1.00 37.88 o

ATOM 3226 CB LYS D 52 54.663 28.851 26.649 1.00 39.06 c

ATOM 3227 CG LYS D 52 54.076 28.941 25.254 1.00 41.38 c

ATOM 3228 CD LYS D 52 52.551 29.006 25.306 1.00 43.38 c

ATOM 3229 CE LYS D 52 51.956 29.144 23.910 1.00 44.51 c

ATOM 3230 NZ LYS D 52 50.463 29.058 23.940 1.00 45.28 N

ATOM 3231 N LEU D 53 57.740 28.516 24.903 1.00 35.77 N

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H H H H H , I H H H H H H ,

Table 3

ATOM 3298 NH2 ARG D 60 72.795 21.192 6.099 1.00 45.88 N

ATOM 3299 N GLY D 61 69.628 25.696 10.108 1.00 30.50 N

ATOM 3300 CA GLY D 61 70.211 25.213 11.354 1.00 29.35 C

ATOM 3301 C GLY D 61 70.450 26.224 12.478 1.00 29.03 C

ATOM 3302 o GLY D 61 71.051 25.882 13.491 1.00 28.44 o

ATOM 3303 N VAL D 62 69.981 27.459 12.311 1.00 28.42 N TOM 3304 CA VAL D 62 70.151 28.499 13.319 1.00 27.63 C

ATOM 3305 C VAL D 62 68.798 29.040 13.787 1.00 27.82 C

ATOM 3306 o VAL D 62 67.971 29.435 12.969 1.00 28.05 o

ATOM 3307 CB VAL D 62 70.971 29.674 12.755 1.00 28.71 C

ATOM 3308 CGI VAL D 62 71.055 30.802 13.789 1.00 27.45 C

ATOM 3309 CG2 VAL D 62 72.370 29.183 12.349 1.00 29.28 C

ATOM 3310 N VAL D 63 68.580 29.082 15.098 1.00 27.12 N

ATOM 3311 CA VAL D 63 67.309 29.568 15.627 1.00 26.23 C

ATOM 3312 C VAL D 63 67.416 30.634 16.721 1.00 27.27 c

ATOM 3313 o VAL D 63 68.472 30.824 17.342 1.00 26.15 o

ATOM 3314 CB VAL D 63 66.472 28.413 16.250 1.00 26.29 c

ATOM 3315 CGI VAL D 63 66.320 27.251 15.257 1.00 25.11 c

ATOM 3316 CG2 VAL D 63 67.135 27.936 17.552 1.00 25.13 c

ATOM 3317 N SER D 64 66.295 31.326 16.933 1.00 27.59 N

ATOM 3318 CA SER D 64 66.162 32.314 18.003 1.00 28.77 C

ATOM 3319 C SER D 64 65.100 31.675 18.897 1.00 28.82 C

ATOM 3320 o SER D 64 64.194 31.001 18.398 1.00 29.07 o

ATOM 3321 CB SER D 64 65.663 33.662 17.466 1.00 29.15 C

ATOM 3322 OG SER D 64 64.344 33.586 16.972 1.00 30.31 o

ATOM 3323 N ILE D 65 65.217 31.850 20.206 1.00 29.32 N

ATOM 3324 CA ILE D 65 64.256 31.269 21.140 1.00 30.33 C

ATOM 3325 C ILE D 65 63.588 32.396 21.941 1.00 31.89 C

ATOM 3326 o ILE D 65 64.252 33.113 22.697 1.00 32.70 o

ATOM 3327 CB ILE D 65 64.967 30.280 22.087 1.00 29.23 C

ATOM 3328 CGI ILE D 65 65.685 29.209 21.262 1.00 29.54 C

ATOM 3329 CG2 ILE D 65 63.967 29.636 23.018 1.00 29.94 C

ATOM 3330 CDl ILE D 65 66.525 28.236 22.086 1.00 28.65 C

ATOM 3331 N LYS D 66 62.277 32.544 21.778 1.00 33.04 N

ATOM 3332 CA LYS D 66 61.537 33.617 22.439 1.00 34.75 C

ATOM 3333 C LYS D 66 60.500 33.186 23.467 1.00 35.49 C

ATOM 3334 o LYS D 66 59.659 32.334 23.195 1.00 35.39 o

ATOM 3335 CB LYS D 66 60.859 34.481 21.365 1.00 36.40 C

ATOM 3336 CG LYS D 66 59.924 35.589 21.865 1.00 38.42 C

ATOM 3337 CD LYS D 66 59.419 36.412 20.674 1.00 41.42 C

ATOM 3338 CE LYS D 66 58.472 37.543 21.071 1.00 43.03 C

ATOM 3339 NZ LYS D 66 57.094 37.064 21.404 1.00 45.12 N

ATOM 3340 N GLY D 67 60.573 33.777 24.658 1.00 36.59 N

ATOM 3341 CA GLY D 67 59.603 33.471 25.695 1.00 38.30 C

ATOM 3342 C GLY D 67 58.311 34.187 25.329 1.00 39.98 C

ATOM 3343 o GLY D 67 58.275 35.415 25.269 1.00 39.06 o

ATOM 3344 N VAL D 68 57.251 33.428 25.075 1.00 41.48 N

ATOM 3345 CA VAL D 68 55.981 34.027 24.679 1.00 43.26 C

ATOM 3346 C VAL D 68 55.437 35.015 25.707 1.00 43.98 C

ATOM 3347 o VAL D 68 55.105 36.145 25.356 1.00 44.25 o TOM 3348 CB VAL D 68 54.903 32.942 24.392 1.00 43.86 C

ATOM 3349 CGI VAL D 68 53.635 33.594 23.829 1.00 43.37 C

ATOM 3350 CG2 VAL D 68 55.447 31.920 23.400 1.00 43.79 C

ATOM 3351 N SER D 69 55.358 34.599 26.970 1.00 44.50 N

ATOM 3352 CA SER D 69 54.843 35.468 28.033 1.00 45.32 C

ATOM 3353 C SER D 69 55.714 36.707 28.248 1.00 45.20 C

ATOM 3354 o SER D 69 55.242 37.840 28.141 1.00 45.09 o

ATOM 3355 CB SER D 69 54.724 34.685 29.348 1.00 44.74 C

ATOM 3356 N ALA D 70 56.988 36.477 28.541 1.00 45.20 N

ATOM 3357 CA ALA D 70 57.942 37.551 28.772 1.00 44.77 C TOM 3358 C ALA D 70 58.131 38.448 27.555 1.00 45.28 C

ATOM 3359 o ALA D 70 58.580 39.586 27.681 1.00 45.68 o

ATOM 3360 CB ALA D 70 59.276 36.957 29.175 1.00 45.09 C

ATOM 3361 N ASN D 71 57.790 37.934 26.378 1.00 45.22 N

ATOM 3362 CA ASN D 71 57.956 38.679 25.136 1.00 45.09 C

ATOM 3363 C ASN D 71 59.421 39.113 24.974 1.00 44.75 C

_OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H H H H H H , H H H H H I H H H H H H H ι H H H H H H H H H o H ln

'r

CJ

zz D tύ (ύ oi oi ei cύ (ύ D D D D D D D wzcozBgop5urtuP5drtOC (-«Urt PtiOήuos ήn>-HK>Hi>uHi>iι; H >< JM >H 4 > ωwωωωωω ω-.H.-.J-,H ιJ ιJ w ω w w ω ω ω ω >H >H >H >H >H < H >H >H H Hq Hq Hq j co co rt rt rt rtrt rt rtrtrt rt rt rt rt rt rt rt H EH EHEH EH EH EH EH EH EH EH H^rtrtrtrtrtεεaεεεεSr^H-iiJi^jHiHHHHH ooc-o irtrtrt

CQ o a Q t muDBNϊa rt (Q U Q QU I- NS < CQ U O Q ft -uαω rt CQ O Q W N rt m ft o o o o z z cjυouc υzcjzzzυuooucjυυooozυoouυuυzoυoυzυυooυwozouoυooozzouocjzcjυ

"fU1 ^ωσ\oHl n^ιn ^ooιΛOH( ι^^ln ^_ (J>□HNfl'f ln ^ooΦOd(Mn_'β'ι ^tDσ^oHNn"l^,ιn ^(DβlOH<Mιη^ln ^oo<Il

^c^I)^o^Dιo^Iιt f.^t-^• ^^l"^ooιDlI)OιflOxxα)lI)l^)σlo Olι^ιOllΛlJl(^( ιIιoooooooooOHHHHddddddι>ιpι^ι^lNNNNw^ι

00 roro. c^r coroi c r rororoc roooroc .oro'Or ' roc r ooc^ romrocηrorotorororoi iηroc rococoi rornr corocooocoroooropncoco^

© εoaoaooaεoεoao

O f f ft t ft ft

zoυooocjzuooooc z

M

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHdHHHHHHHHHHHHHHHHHHHHHHHHHHH d » o H O d d ffi

in ro

mmmιΛmooooddHHdNNNNN( Nt nnιn(θπnπ v"P"f "rvιnιnι ι Λιn h ωoo(Dθθθθθ(D<Jioιoιβi(iιιJi<i(θ r~r_"i^r~r~oomωcDmooaaffiωaΦ_ω∞ωω ωmωωm∞mωcoΦω∞noooo mmιi)θ maDθ3 )ωωmmmωω_ffimωωi-i- _cD > oσι

Q Q Q Q Q Q QQ Q Q Q a Q QQ Q QQ Q QQQ Q QO Q Q Q D Q Q Q Q a Q QQ Q Q Q Q Q QQ Q QQQ Q QQ Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q 0, D rt rt rt rt rt - P- S 0S a o w J rt H rt rt rt rt rt CO OT

H CM H CM H CM H CM H CM

CQ O Q Q rt ft CQ rt CQ CD Q Q rt CQ O D Q rt CQ rt CQ CJ) rt CQ rt CQ rt CQ CJ) CJ) rt CQ CJ) CJ) oυυoozcjoozuυoozoυoυouuzcjuooυoozoooozocjouozυooozυc ocjzoooυoozυoocjoc z

o aoaoaoaoaoεoEoεoεoεoεoεoεoεoεoaoaoaooaoaaoεoaoaoaoaoεoaoaooaoaεoεoεoεoεoaoooooooooooooooooooooooooooooo O ft ft ft ft ft ft ft ft ^ ft ft ft ft ft ft ftft ft ft ft ft ft ft ft ft f^ ft ft ft ft ft ft ft ft ft ft ft ftft m

Table 3

ATOM 3496 CA ASP D 90 73.571 38.889 17.616 1.00 41.12 c

ATOM 3497 C ASP D 90 73.844 37.802 18.654 1.00 41.18 c

ATOM 3498 o ASP D 90 74.408 36.755 18.332 1.00 42.37 o

ATOM 3499 CB ASP D 90 74.907 39.412 17.064 1.00 41.11 c

ATOM 3500 CG ASP D 90 75.656 40.326 18.051 1.00 41.39 c

ATOM 3501 ODl ASP D 90 75.268 40.402 19.239 1.00 40.75 o

ATOM 3502 OD2 ASP D 90 76.651 40.965 17.631 1.00 39.90 o

ATOM 3503 N GLU D 91 73.445 38.045 19.897 1.00 40.48 N

ATOM 3504 CA GLU D 91 73.662 37.072 20.965 1.00 40.42 c

ATOM 3505 C GLU D 91 72.391 36.250 21.201 1.00 38.92 c

ATOM 3506 o GLU D 91 72.300 35.498 22.172 1.00 38.93 o

ATOM 3507 CB GLU D 91 74.062 37.788 22.265 1.00 40.64 c

ATOM 3508 CG GLU D 91 75.140 38.852 22.089 1.00 41.05 c

ATOM 3509 CD GLU D 91 75.549 39.509 23.405 1.00 41.33 c

ATOM 3510 OEl GLU D 91 74.670 40.048 24.112 1.00 40.56 o

ATOM 3511 OE2 GLU D 91 76.755 39.488 23.728 1.00 42.06 o

ATOM 3512 N CYS D 92 71.419 36.386 20.305 1.00 37.53 N

ATOM 3513 CA CYS D 92 70.155 35.662 20.434 1.00 37.33 C

ATOM 3514 C CYS D 92 69.965 34.523 19.428 1.00 37.35 C

ATOM 3515 o CYS D 92 68.857 33.998 19.289 1.00 37.11 o

ATOM 3516 CB CYS D 92 68.978 36.631 20.300 1.00 37.57 c

ATOM 3517 SG CYS D 92 68.952 37.991 21.499 1.00 36.54 s

ATOM 3518 N PHE D 93 71.040 34.133 18.742 1.00 36.58 N

ATOM 3519 CA PHE D 93 70.973 33.075 17.742 1.00 35.75 c

ATOM 3520 C PHE D 93 71.817 31.858 18.128 1.00 35.61 c

ATOM 3521 o PHE D 93 72.961 31.994 18.560 1.00 35.37 o

ATOM 3522 CB PHE D 93 71.393 33.654 16.386 1.00 35.89 c

ATOM 3523 CG PHE D 93 70.464 34.732 15.889 1.00 36.43 c

ATOM 3524 CDl PHE D 93 69.186 34.414 15.442 1.00 36.23 c

ATOM 3525 CD2 PHE D 93 70.831 36.074 15.950 1.00 36.97 c

ATOM 3526 CEl PHE D 93 68.281 35.411 15.069 1.00 36.80 c

ATOM 3527 CE2 PHE D 93 69.936 37.079 15.579 1.00 37.17 c

ATOM 3528 CZ PHE D 93 68.652 36.743 15.138 1.00 37.41 c

ATOM 3529 N PHE D 94 71.244 30.669 17.956 1.00 33.92 N

ATOM 3530 CA PHE D 94 71.906 29.435 18.344 1.00 33.26 c

ATOM 3531 C PHE D 94 71.802 28.315 17.300 1.00 33.32 c

ATOM 3532 o PHE D 94 70.737 28.117 16.689 1.00 32.41 o

ATOM 3533 CB PHE D 94 71.279 28.933 19.649 1.00 33.05 c

ATOM 3534 CG PHE D 94 71.288 29.944 20.775 1.00 33.05 c

ATOM 3535 CDl PHE D 94 72.357 29.998 21.675 1.00 32.73 c

ATOM 3536 CD2 PHE D 94 70.217 30.824 20.952 1.00 32.88 c

ATOM 3537 CEl PHE D 94 72.359 30.906 22.733 1.00 32.76 c

ATOM 3538 CE2 PHE D 94 70.206 31.739 22.006 1.00 32.89 c

ATOM 3539 CZ PHE D 94 71.279 31.780 22.901 1.00 33.32 c

ATOM 3540 N PHE D 95 72.899 27.582 17.109 1.00 31.85 N

ATOM 3541 CA PHE D 95 72.899 26.457 16.179 1.00 32.60 c

ATOM 3542 C PHE D 95 72.089 25.339 16.844 1.00 32.30 c

ATOM 3543 o PHE D 95 72.397 24.938 17.968 1.00 32.05 o

ATOM 3544 CB PHE D 95 74.324 25.934 15.923 1.00 33.10 c

ATOM 3545 CG PHE D 95 75.195 26.866 15.119 1.00 32.91 c

ATOM 3546 CDl PHE D 95 76.261 27.535 15.721 1.00 33.04 c

ATOM 3547 CD2 PHE D 95 74.968 27.055 13.757 1.00 32.86 c

ATOM 3548 CEl PHE D 95 77.097 28.381 14.971 1.00 33.29 c

ATOM 3549 CE2 PHE D 95 75.793 27.898 12.997 1.00 33.32 c

ATOM 3550 CZ PHE D 95 76.859 28.561 13.607 1.00 32.86 c

ATOM 3551 N GLU D 96 71.048 24.854 16.172 1.00 31.87 N

ATOM 3552 CA GLU D 96 70.254 23.766 16.733 1.00 32.18 c

ATOM 3553 C GLU D 96 70.703 22.471 16.084 1.00 33.15 c

ATOM 3554 o GLU D 96 70.798 22.377 14.858 1.00 32.44 o

ATOM 3555 CB GLU D 96 68.756 23.928 16.467 1.00 31.12 c

ATOM 3556 CG GLU D 96 67.933 22.775 17.062 1.00 29.98 c

ATOM 3557 CD GLU D 96 66.498 22.755 16.562 1.00 30.66 c

ATOM 3558 OEl GLU D 96 66.294 22.331 15.406 1.00 30.70 o

ATOM 3559 OE2 GLU D 96 65.584 23.166 17.316 1.00 28.95 o

ATOM 3560 N ARG D 97 70.958 21.470 16.915 1.00 34.24 N

ATOM 3561 CA ARG D 97 71.398 20.178 16.420 1.00 35.69 C oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH lon^ninNm^Ho^M OiJiNinofloooiniM Odnodπ inNΦOH CMifl mΛn^aiflo^fliMwnoσioioinroωhωnoNn nl ^ ι^Nιodc>lln ι^τ)ι^τ)eoιΛω^)^H^H "f N^»OHO^dOlι^τ) lnln ldι»)oιIιιnO'»oιn^<I>ιnn "^^, lNlJln ιnooc ι«ιo ι^ul NH(^ dnωooιlldlndNln! ( l>l<l'ι>)ONdmO(o <.dι») ιd Φo«^ιoιooo ΦΦ*<M"rl ΦΦι (Dιn^Φιn^oxo^ιn

^ffl Φ ΦΦ ΦΦ^ ιnΦ^lnffl eo_ιIloσιom_^mo)^o OHH ι ι ιι ι«lOOOdOιxl^a)d( O(^,l^ιn'»Φιn ^d Hno<>^

HHHHHHHHHHHHHHHHHHHHHHCMHCMHHHHHHHCMCMCgCMCMCslCMCMCMCMCMCMCMHHHCMCMCM MCMCMCMCMCMCMCMCMCMCMCMCMCMH

r- r- r- r- t— r- ^r~»oofloωoω oxm<n<Λθ>oιιjιijιoιoιooooooddHd dd M! NNNNN! nιη( nnπιnιη(^,)nι^,ιn>f ^v»«^ σισ*cΛσισισ><7ισ*σ\<τ»σ σ*<Λ<xισισι<τtσ^cτ»oooooooooooooooooooooooooooooooooooooooo

HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH QQaQQQQQQaQQQQOQQQaQQQQQQQQQaC-OQQQQQQQQQQQQaaQQQQQQQQQQQQQQQQQQQQ

.... H CM Q cj a wcM K a. ft cQ Q Q „ CQ C_J) Q, C-i ω ft CQ O rt CQ O Q Q .- , ffl U Q Q (J M KI S ft CQ CD υou u u zcj z z zu cjo u cj u o z uoo oooo ~ozouoυozuυocjuozzuc ooooz zoυocjcjocjc uυozuc oocj

CMM if") «'^ iιn Φco rc~- »co <Λ θ H M rθ 'r ιn co r- co σι θ H f 'r ιn co r~ a) σ> θ H C Cθ ", ιn ιo t~ D Λ θ H Cj rθ 'i ιn cD r-- co ^ φ φ φ lg φ . ^ ^ ^ j ^ ^ ^ i^ ^ ^ o Q π ^ ij i^j oj φ ^ji i^j i^j oi i^jii^j i^j in cn i o o o O O O O O O O d d d d d d d d d l N N IN N N N N

00 >n ιn ι ιnιn ιn ιπ ιn > ιn ι ιn ιn ιn ιn ιn ι >n >n ιn ιn ιo >n >θ Ln >n ιn iΛ in i i/) ιπ ιn >n ιn ι ιn ι Φ Φ Φ ΦΦ Φ Φ Φ Φ Φ Φ ΦΦ Φ Φ Φ Φ ) M (θ c ιθ f fθ c (η ro ( c ( ro c r c < oo r n c co ro c c ro ro r (θ ( ro (o co ro aoaoaoaoaaaaaaaaaεaaaεaaao εaa saaaaaaaε aa εεεaεεεaεεaaεεε

O H H EH HoHoH EoH Hoo o EoHoHoHo ε EH EoH EoH HoEHoEH H EoH EoH H oooδaoa δoaδaaδsδδaaδao ooooooooooεao EoHoH Eoaεaε H EoH EoHoHoEH EoH EoHoEH EoH EoH EoH EoHoEH EoH EoHoEH EoH EoHoH it ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft f ft ft ft 'i ti ft ft ft < ft ft ft < < ft < ft ft ft f f fi < < £, < f t t f d. ft't f f i fi fi fZ l' f fZ f ft fi

Table 3

ATOM 3628 ODl ASN D 104 66.739 18.037 19.054 1.00 29.97 o

ATOM 3629 ND2 ASN D 104 65.949 20.129 18.962 1.00 29.97 N

ATOM 3630 N THR D 105 70.583 20.177 21.095 1.00 25.93 N

ATOM 3631 CA THR D 105 71.567 21.047 21.745 1.00 26.23 C

ATOM 3632 C THR D 105 71.494 22.398 21.050 1.00 26.45 C

ATOM 3633 0 THR D 105 71.169 22.481 19.858 1.00 25.80 o

ATOM 3634 CB THR D 105 73.027 20.518 21.667 1.00 26.04 C

ATOM 3635 OG1 THR D 105 73.457 20.456 20.300 1.00 26.82 o

ATOM 3636 CG2 THR D 105 73.132 19.158 22.319 1.00 26.71 C

ATOM 3637 N TYR D 106 71.792 23.453 21.804 1.00 27.12 N

ATOM 3638 CA TYR D 106 71.751 24.815 21.291 1.00 27.86 C

ATOM 3639 C TYR D 106 73.087 25.500 21.565 1.00 29.60 C

ATOM 3640 o TYR D 106 73.414 25.799 22.714 1.00 29.29 o

ATOM 3641 CB TYR D 106 70.590 25.551 21.966 1.00 26.16 C

ATOM 3642 CG TYR D 106 69.281 24.950 21.546 1.00 25.64 C

ATOM 3643 CDl TYR D 106 68.707 25.285 20.316 1.00 24.14 C

ATOM 3644 CD2 TYR D 106 68.671 23.958 22.314 1.00 23.58 c

ATOM 3645 CEl TYR D 106 67.567 24.636 19.856 1.00 25.46 c

ATOM 3646 CE2 TYR D 106 67.533 23.301 21.861 1.00 25.15 c

ATOM 3647 CZ TYR D 106 66.988 23.643 20.631 1.00 24.17 c

ATOM 3648 OH TYR D 106 65.902 22.965 20.148 1.00 24.91 o

ATOM 3649 N ARG D 107 73.845 25.732 20.494 1.00 31.16 N

ATOM 3650 CA ARG D 107 75.174 26.336 20.574 1.00 32.67 C

ATOM 3651 C ARG D 107 75.199 27.760 20.030 1.00 33.24 C

ATOM 3652 o ARG D 107 74.730 28.020 18.924 1.00 33.30 o

ATOM 3653 CB ARG D 107 76.158 25.463 19.798 1.00 32.67 c

ATOM 3654 CG ARG D 107 77.603 25.889 19.865 1.00 32.58 c

ATOM 3655 CD ARG D 107 78.476 24.804 19.241 1.00 31.51 c

ATOM 3656 NE ARG D 107 78.094 24.520 17.862 1.00 29.79 N

ATOM 3657 CZ ARG D 107 78.500 25.227 16.814 1.00 31.11 C

ATOM 3658 NHl ARG D 107 79.311 26.267 16.989 1.00 31.22 N

ATOM 3659 NH2 ARG D 107 78.104 24.899 15.589 1.00 29.39 N

ATOM 3660 N SER D 108 75.752, 28.676 20.822 1.00 34.39 N

ATOM 3661 CA SER D 108 75.843 30.091 20.456 1.00 35.36 C

ATOM 3662 C SER D 108 76.526 30.316 19.108 1.00 36.03 C

ATOM 3663 o SER D 108 77.611 29.789 18.861 1.00 36.15 o

ATOM 3664 CB SER D 108 76.600 30.858 21.551 1.00 35.17 c

ATOM 3665 OG SER D 108 76.895 32.186 21.163 1.00 33.39 o

ATOM 3666 N ARG D 109 75.889 31.092 18.233 1.00 36.63 N

ATOM 3667 CA ARG D 109 76.480 31.373 16.930 1.00 38.27 C

ATOM 3668 C ARG D 109 77.601 32.401 17.088 1.00 39.85 C

ATOM 3669 o ARG D 109 78.510 32.460 16.264 1.00 40.21 o

ATOM 3670 CB ARG D 109 75.426 31.906 15.946 1.00 37.43 C

ATOM 3671 CG ARG D 109 75.960 32.088 14.509 1.00 36.51 C

ATOM 3672 CD ARG D 109 74.879 32.531 13.518 1.00 35.80 C

ATOM 3673 NE ARG D 109 74.373 33.875 13.799 1.00 36.06 N

ATOM 3674 CZ ARG D 109 73.471 34.516 13.055 1.00 35.79 C

ATOM 3675 NHl ARG D 109 72.962 33.941 11.977 1.00 35.72 N

ATOM 3676 NH2 ARG D 109 73.076 35.740 13.385 1.00 34.84 N

ATOM 3677 N LYS D 110 77.535 33.202 18.153 1.00 41.38 N

ATOM 3678 CA LYS D 110 78.548 34.224 18.409 1.00 42.34 C

ATOM 3679 C LYS D 110 79.756 33.629 19.142 1.00 42.60 C

ATOM 3680 o LYS D 110 80.887 33.701 18.654 1.00 42.50 o

ATOM 3681 CB LYS D 110 77.950 35.372 19.228 1.00 43.39 C

ATOM 3682 CG LYS D 110 78.764 36.671 19.157 1.00 45.14 C

ATOM 3683 CD LYS D 110 78.184 37.733 20.089 1.00 46.94 C

ATOM 3684 CE LYS D 110 78.868 39.075 19.907 1.00 46.68 C

ATOM 3685 NZ LYS D 110 78.587 39.607 18.551 1.00 48.63 N

ATOM 3686 N TYR D 111 79.505 33.048 20.313 1.00 42.45 N

ATOM 3687 CA TYR D 111 80.536 32.405 21.121 1.00 42.43 C

ATOM 3688 C TYR D 111 80.366 30.917 20.802 1.00 41.95 C

ATOM 3689 o TYR D 111 79.767 30.157 21.567 1.00 41.52 o

ATOM 3690 CB TYR D 111 80.276 32.716 22.604 1.00 42.93 C

ATOM 3691 CG TYR D 111 80.008 34.192 22.835 1.00 44.45 C

ATOM 3692 CDl TYR D 111 81.028 35.142 22.685 1.00 44.58 C

ATOM 3693 CD2 TYR D 111 78.716 34.656 23.100 1.00 44.75 C Table 3

ATOM 3694 CEl TYR D 111 80.763 36.515 22.779 1.00 44.52 c

ATOM 3695 CE2 TYR D 111 78.439 36.035 23.198 1.00 44.98 c

ATOM 3696 CZ TYR D 111 79.468 36.958 23.031 1.00 44.96 c

ATOM 3697 OH TYR D 111 79.198 38.313 23.072 1.00 43.46 o

ATOM 3698 N THR D 112 80.900 30.530 19.647 1.00 41.87 N

ATOM 3699 CA THR D 112 80.780 29.176 19.106 1.00 42.40 C

ATOM 3700 C THR D 112 81.192 27.950 19.913 1.00 42.28 C

ATOM 3701 o THR D 112 81.138 26.839 19.395 1.00 42.54 o

ATOM 3702 CB THR D 112 81.475 29.082 17.731 1.00 42.16 C

ATOM 3703 OG1 THR D 112 82.874 29.351 17.884 1.00 41.13 o

ATOM 3704 CG2 THR D 112 80.859 30.088 16.748 1.00 41.44 c

ATOM 3705 N SER D 113 81.587 28.118 21.168 1.00 42.10 N

ATOM 3706 CA SER D 113 81.975 26.954 21.955 1.00 42.41 C

ATOM 3707 C SER D 113 81.080 26.724 23.163 1.00 41.80 C

ATOM 3708 o SER D 113 81.165 25.685 23.822 1.00 41.36 o

ATOM 3709 CB SER D 113 83.435 27.081 22.409 1.00 42.58 C

ATOM 3710 OG SER D 113 84.313 26.966 21.300 1.00 42.66 o

ATOM 3711 N TRP D 114 80.213 27.686 23.445 1.00 41.58 N

ATOM 3712 CA TRP D 114 79.332 27.576 24.599 1.00 41.47 C

ATOM 3713 C TRP D 114 77.904 27.130 24.259 1.00 39.93 C

ATOM 3714 o TRP D 114 77.361 27.475 23.206 1.00 39.72 o

ATOM 3715 CB TRP D 114 79.332 28.910 25.356 1.00 43.57 C

ATOM 3716 CG TRP D 114 80.737 29.376 25.716 1.00 46.05 C

ATOM 3717 CDl TRP D 114 81.863 28.593 25.827 1.00 46.16 C

ATOM 3718 CD2 TRP D 114 81.150 30.713 26.040 1.00 46.32 C

ATOM 3719 NEl TRP D 114 82.943 29.363 26.198 1.00 46.71 N

ATOM 3720 CE2 TRP D 114 82.536 30.665 26.336 1.00 47.01 C

ATOM 3721 CE3 TRP D 114 80.486 31.947 26.110 1.00 47.32 C

ATOM 3722 CZ2 TRP D 114 83.265 31.805 26.699 1.00 47.13 C

ATOM 3723 CZ3 TRP D 114 81.216 33.085 26.469 1.00 47.34 c

ATOM 3724 CH2 TRP D 114 82.589 33.002 26.759 1.00 47.61 c

ATOM 3725 N TYR D 115 77.314 26.356 25.168 1.00 38.33 N

ATOM 3726 CA TYR D 115 75.960 25.828 25.006 1.00 36.97 C

ATOM 3727 C TYR D 115 74.963 26.369 26.025 1.00 36.33 C

ATOM 3728 o TYR D 115 75.331 26.736 27.138 1.00 35.87 o

ATOM 3729 CB TYR D 115 75.942 24.304 25.164 1.00 36.22 c

ATOM 3730 CG TYR D 115 76.677 23.519 24.111 1.00 36.66 c

ATOM 3731 CDl TYR D 115 78.025 23.190 24.268 1.00 36.79 c

ATOM 3732 CD2 TYR D 115 76.019 23.076 22.965 1.00 36.10 c

ATOM 3733 CEl TYR D 115 78.701 22.430 23.303 1.00 36.07 c

ATOM 3734 CE2 TYR D 115 76.683 22.319 21.998 1.00 36.64 c

ATOM 3735 CZ TYR D 115 78.024 22.001 22.174 1.00 36.29 c

ATOM 3736 OH TYR D 115 78.680 21.264 21.215 1.00 37.12 o

ATOM 3737 N VAL D 116 73.695 26.407 25.635 1.00 35.23 N

ATOM 3738 CA VAL D 116 72.642 26.819 26.551 1.00 34.37 C

ATOM 3739 C VAL D 116 72.531 25.584 27.446 1.00 34.42 C

ATOM 3740 o VAL D 116 72.486 24.459 26.952 1.00 34.27 o

ATOM 3741 CB VAL D 116 71.323 27.074 25.793 1.00 34.00 c

ATOM 3742 CGI VAL D 116 70.193 27.308 26.770 1.00 33.39 c

ATOM 3743 CG2 VAL D 116 71.488 28.278 24.859 1.00 32.59 c

ATOM 3744 N ALA D 117 72.516 25.782 28.758 1.00 34.87 N TOM 3745 CA ALA D 117 72.467 24.649 29.670 1.00 35.64 c

ATOM 3746 C ALA D 117 71.928 25.005 31.042 1.00 36.78 C

ATOM 3747 o ALA D 117 71.969 26.163 31.464 1.00 37.35 o

ATOM 3748 CB ALA D 117 73.860 24.049 29.816 1.00 34.13 c

ATOM 3749 N LEU D 118 71.436 23.989 31.741 1.00 37.10 N

ATOM 3750 CA LEU D 118 70.900 24.169 33.077 1.00 38.06 c

ATOM 3751 C LEU D 118 71.645 23.263 34.048 1.00 38.81 C

ATOM 3752 o LEU D 118 72.098 22.184 33.670 1.00 39.30 o

ATOM 3753 CB LEU D 118 69.407 23.837 33.094 1.00 37.70 C

ATOM 3754 CG LEU D 118 68.470 24.742 32.287 1.00 37.45 c

ATOM 3755 CDl LEU D 118 67.059 24.204 32.409 1.00 37.34 c

ATOM 3756 CD2 LEU D 118 68.536 26.189 32.801 1.00 37.18 c

ATOM 3757 N LYS D 119 71.773 23.709 35.294 1.00 40.12 N

ATOM 3758 CA LYS D 119 72.457 22.938 36.332 1.00 41.45 C

ATOM 3759 C LYS D 119 71.459 22.071 37.089 1.00 41.83 C Table 3

ATOM 3760 O LYS D 119 70.251 22.332 37.059 1.00 41.78 o

ATOM 3761 CB LYS D 119 73.172 23.882 37.311 1.00 41.32 c

ATOM 3762 N ARG D 120 71.967 21.044 37.767 1.00 41.92 N

ATOM 3763 CA ARG D 120 71.121 20.127 38.531 1.00 42.76 C

ATOM 3764 C ARG D 120 70.283 20.873 39.562 1.00 43.01 C

ATOM 3765 0 ARG D 120 69.272 20.367 40.036 1.00 42.82 o

ATOM 3766 CB ARG D 120 71.977 19.066 39.232 1.00 41.45 C

ATOM 3767 N THR D 121 70.705 22.087 39.896 1.00 44.40 N

ATOM 3768 CA THR D 121 70.002 22.902 40.878 1.00 45.13 C

ATOM 3769 C THR D 121 68.783 23.614 40.294 1.00 45.85 C

ATOM 3770 0 THR D 121 67.838 23.928 41.015 1.00 46.11 o

ATOM 3771 CB THR D 121 70.938 23.968 41.492 1.00 45.88 C

ATOM 3772 OG1 THR D 121 71.355 24.884 40.474 1.00 46.18 o

ATOM 3773 CG2 THR D 121 72.170 23.311 42.107 1.00 45.54 C

ATOM 3774 N GLY D 122 68.795 23.861 38.990 1.00 46.02 N

ATOM 3775 CA GLY D 122 67.676 24.550 38.380 1.00 46.48 C

ATOM 3776 C GLY D 122 68.100 25.922 37.901 1.00 47.04 C

ATOM 3777 0 GLY D 122 67.324 26.662 37.291 1.00 47.14 o

ATOM 3778 N GLN D 123 69.348 26.269 38.191 1.00 47.07 N

ATOM 3779 CA GLN D 123 69.901 27.544 37.766 1.00 47.46 C

ATOM 3780 C GLN D 123 70.659 27.275 36.471 1.00 47.19 C

ATOM 3781 0 GLN D 123 71.162 26.169 36.261 1.00 46.75 o

ATOM 3782 CB GLN D 123 70.844 28.091 38.841 1.00 48.11 C

ATOM 3783 CG GLN D 123 70.171 28.283 40.208 1.00 50.27 c

ATOM 3784 CD GLN D 123 68.986 29.255 40.164 1.00 51.25 c

ATOM 3785 OEl GLN D 123 69.148 30.434 39.844 1.00 52.08 o

ATOM 3786 NE2 GLN D 123 67.792 28.758 40.488 1.00 52.19 N

ATOM 3787 N TYR D 124 70.728 28.266 35.589 1.00 46.86 N

ATOM 3788 CA TYR D 124 71.437 28.057 34.334 1.00 46.79 c

ATOM 3789 C TYR D 124 72.906 27.787 34.621 1.00 46.37 c

ATOM 3790 o TYR D 124 73.376 28.001 35.732 1.00 45.85 o

ATOM 3791 CB TYR D 124 71.280 29.267 33.392 1.00 46.13 C

ATOM 3792 CG TYR D 124 71.982 30.538 33.819 1.00 46.17 C

ATOM 3793 CDl TYR D 124 73.378 30.606 33.889 1.00 46.43 C

ATOM 3794 CD2 TYR D 124 71.255 31.679 34.141 1.00 46.18 C

ATOM 3795 CEl TYR D 124 74.027 31.773 34.271 1.00 45.82 C

ATOM 3796 CE2 TYR D 124 71.895 32.855 34.525 1.00 46.61 C

ATOM 3797 CZ TYR D 124 73.281 32.893 34.588 1.00 46.75 C

ATOM 3798 OH TYR D 124 73.916 34.050 34.968 1.00 46.83 o

ATOM 3799 N LYS D 125 73.623 27.309 33.614 1.00 46.56 N

ATOM 3800 CA LYS D 125 75.037 27.012 33.753 1.00 46.99 C

ATOM 3801 C LYS D 125 75.827 27.925 32.810 1.00 48.06 C

ATOM 3802 0 LYS D 125 75.468 28.063 31.639 1.00 47.64 o

ATOM 3803 CB LYS D 125 75.286 25.536 33.412 1.00 46.02 C

ATOM 3804 CG LYS D 125 76.737 25.092 33.511 1.00 44.48 C

ATOM 3805 CD LYS D 125 76.882 23.588 33.317 1.00 43.98 c

ATOM 3806 CE LYS D 125 78.340 23.164 33.502 1.00 44.57 c

ATOM 3807 NZ LYS D 125 78.571 21.693 33.380 1.00 44.60 N

ATOM 3808 N LEU D 126 76.885 28.557 33.326 1.00 49.01 N

ATOM 3809 CA LEU D 126 77.709 29.456 32.515 1.00 49.83 C

ATOM 3810 C LEU D 126 78.138 28.779 31.227 1.00 50.46 C

ATOM 3811 0 LEU D 126 78.679 27.671 31.249 1.00 50.50 o

ATOM 3812 CB LEU D 126 78.961 29.896 33.275 1.00 50.45 C

ATOM 3813 CG LEU D 126 78.867 31.113 34.195 1.00 50.81 c

ATOM 3814 CDl LEU D 126 80.256 31.435 34.713 1.00 51.18 c

ATOM 3815 CD2 LEU D 126 78.300 32.310 33.440 1.00 51.05 c

ATOM 3816 N GLY D 127 77.902 29.451 30.107 1.00 50.73 N

ATOM 3817 CA GLY D 127 78.273 28.887 28.825 1.00 51.40 c

ATOM 3818 C GLY D 127 79.724 28.447 28.784 1.00 51.76 c

ATOM 3819 0 GLY D 127 80.065 27.458 28.135 1.00 51.74 o

ATOM 3820 N SER D 128 80.581 29.181 29.485 1.00 52.20 N TOM 3821 CA SER D 128 82.009 28.877 29.517 1.00 52.38 C

ATOM 3822 C SER D 128 82.332 27.552 30.204 1.00 52.36 c

ATOM 3823 0 SER D 128 83.422 27.010 30.032 1.00 52.38 o

ATOM 3824 CB SER D 128 82.766 30.015 30.210 1.00 51.84 c

ATOM 3825 OG SER D 128 82.245 30.256 31.508 1.00 52.17 o CO zou o υzcj u ouoo z υυo z υo oou u z cjoo z υ cjo υuuo z zυu o υuu υ z zuoou z ouoooooz υooυ υυo

oooooooooooooooooooooooooσoooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H HH H H H H H H H , H H H H H H H I H H H H ,

r~ in ro

Q3 coωco ιDωωco

Q Q ^{Q Q} Q a ^{Q Q} O Q Q a Q Q Q Q Q Q Q Q Q Q Q Q Q Q O Q D D Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q a Q Q Q Q Q Q Q D Q a Q Q Q Q Q Q Q Q co wco w co ctf oS tf ps βi cc; PΪ H >H >H >H O O O O O O O >H H H H Z Z Z Z Z Z Z Z Z CO CO CO W W CO CO CO CO h U U U (3 B( lH lH llι llι (lι 0( t!I U - U (5O U UI3 U _ !l l5J κl ιJHi μi J ιJ J J

H CM H CM H CM H H CM t co rt ca 5 ⁾ rt _Λ rt pQ DQ rt rt m u a ω ω rt O U ^Q U H < m < CQ O O Q ft o a a z o u o c^j z o c^j o u o o z o o o z cj o oo uoz oooz υooocjoo z z o u o o o u u z z u oou z υoo υo oo z o o o o o o

Table 3

ATOM 3892 N PHE D 139 68.521 18.878 25.622 1.00 27.78 N

ATOM 3893 CA PHE D 139 67.125 19.281 25.725 1.00 27.77 C

ATOM 3894 c PHE D 139 66.203 18.467 24.832 1.00 28.45 C

ATOM 3895 o PHE D 139 66.593 18.021 23.752 1.00 27.88 0

ATOM 3896 CB PHE D 139 66.977 20.753 25.336 1.00 27.55 C

ATOM 3897 CG PHE D 139 67.586 21.709 26.317 1.00 28.64 C

ATOM 3898 CDl PHE D 139 68.936 22.036 26.249 1.00 28.56 C

ATOM 3899 CD2 PHE D 139 66.808 22.275 27.324 1.00 28.87 C

ATOM 3900 CEl PHE D 139 69.504 22.913 27.173 1.00 30.32 C

ATOM 3901 CE2 PHE D 139 67.365 23.152 28.255 1.00 29.77 c

ATOM 3902 CZ PHE D 139 68.719 23.472 28.179 1.00 29.35 c

ATOM 3903 N LEU D 140 64.960 18.314 25.271 1.00 28.29 N

ATOM 3904 CA LEU D 140 63.966 17.586 24.501 1.00 28.59 C

ATOM 3905 C LEU D 140 62.785 18.526 24.250 1.00 29.50 C

ATOM 3906 o LEU D 140 62.099 18.943 25.187 1.00 29.38 o

ATOM 3907 CB LEU D 140 63.496 16.359 25.281 1.00 29.24 C

ATOM 3908 CG LEU D 140 62.673 15.280 24.567 1.00 31.29 C

ATOM 3909 CDl LEU D 140 63.522 14.623 23.477 1.00 31.65 C

ATOM 3910 CD2 LEU D 140 62.212 14.221 25.592 1.00 30.86 C

ATOM 3911 N PRO D 141 62.548 18.903 22.985 1.00 30.09 N

ATOM 3912 CA PRO D 141 61.418 19.795 22.727 1.00 31.12 C

ATOM 3913 C PRO D 141 60.091 19.067 22.980 1.00 32.93 C

ATOM 3914 o PRO D 141 59.897 17.931 22.533 1.00 32.97 o

ATOM 3915 CB PRO D 141 61.607 20.184 21.260 1.00 30.79 C

ATOM 3916 CG PRO D 141 62.294 18.994 20.689 1.00 32.15 C

ATOM 3917 CD PRO D 141 63.310 18.658 21.747 1.00 29.91 C

ATOM 3918 N MET D 142 59.194 19.718 23.716 1.00 33.86 N

ATOM 3919 CA MET D 142 57.892 19.132 24.030 1.00 35.77 c

ATOM 3920 C MET D 142 56.747 20.096 23.728 1.00 36.97 c

ATOM 3921 o MET D 142 56.921 21.317 23.711 1.00 36.81 o

ATOM 3922 CB MET D 142 57.820 18.728 25.511 1.00 35.48 c

ATOM 3923 CG MET D 142 58.802 17.641 25.919 1.00 35.60 c

ATOM 3924 SD MET D 142 58.757 17.282 27.684 1.00 36.85 S

ATOM 3925 CE MET D 142 57.505 15.979 27.723 1.00 35.78 c

ATOM 3926 N SER D 143 55.572 19.529 23.499 1.00 38.75 N

ATOM 3927 CA SER D 143 54.375 20.304 23.202 1.00 40.93 c

ATOM 3928 C SER D 143 54.012 21.269 24.320 1.00 41.71 C

ATOM 3929 o SER D 143 54.180 20.966 25.502 1.00 40.96 o

ATOM 3930 CB SER D 143 53.194 19.362 22.976 1.00 41.49 c

ATOM 3931 OG SER D 143 51.973 20.068 23.054 1.00 43.53 o

ATOM 3932 N ALA D 144 53.508 22.435 23.939 1.00 43.61 N

ATOM 3933 CA ALA D 144 53.092 23.430 24.915 1.00 46.08 C

ATOM 3934 C ALA D 144 51.644 23.151 25.325 1.00 47.46 C

ATOM 3935 o ALA D 144 50.915 24.060 25.720 1.00 48.06 o

ATOM 3936 CB ALA D 144 53.210 24.815 24.319 1.00 46.29 C

ATOM 3937 N LYS D 145 51.239 21.885 25.223 1.00 48.83 N

ATOM 3938 CA LYS D 145 49.887 21.465 25.587 1.00 50.09 c

ATOM 3939 C LYS D 145 48.841 22.277 24.834 1.00 50.66 c

ATOM 3940 o LYS D 145 48.764 22.067 23.603 1.00 51.83 o

ATOM 3941 CB LYS D 145 49.679 21.615 27.099 1.00 49.26 c

TER 3942 LYS D 145

ATOM 3943 N ASN E 150 63.387 18.498 -44.664 1.00 47.77 N

ATOM 3944 CA ASN E 150 63.113 19.128 -43.338 1.00 46.93 C

ATOM 3945 C ASN E 150 62.016 18.447 -42.513 1.00 46.19 C

ATOM 3946 o ASN E 150 62.081 18.424 -41.284 1.00 46.58 o

ATOM 3947 CB ASN E 150 62.737 20.595 -43.521 1.00 46.99 C

ATOM 3948 N LYS E 151 61.010 17.896 -43.184 1.00 45.03 N

ATOM 3949 CA LYS E 151 59.899 17.209 -42.519 1.00 43.69 C

ATOM 3950 C LYS E 151 60.297 15.780 -42.130 1.00 43.11 C

ATOM 3951 o LYS E 151 60.737 14.997 -42.972 1.00 42.16 o

ATOM 3952 CB LYS E 151 58.666 17.186 -43.434 1.00 42.74 c

ATOM 3953 N ARG E 152 60.135 15.427 -40.856 1.00 42.03 N

ATOM 3954 CA ARG E 152 60.542 14.090 -40.419 1.00 40.41 C

ATOM 3955 C ARG E 152 59.854 13.582 -39.156 1.00 39.14 C

ATOM 3956 o ARG E 152 59.402 14.355 -38.305 1.00 38.94 o

ATOM 3957 CB ARG E 152 62.056 14.073 -40.194 1.00 40.84 C CO ouzυzz z cjooυzoo oυuυ zoυo uocj cjcj cjo o zcjoou cjoo z uooυoz u uocj ocjzo υoooo zzcjooooo

oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

I H H H H , HHHHHHHHH. HHdHHHHH^,

CM Λr~rocιi'rooocDHioιθι 'r<i)'rθ(_ιθoooιθHCMHCDcsiιncocιc>jσιr--θ'rfθCM'rιnooHin'rιn Mc τ>coHr-~r^

N^ιffl NOOl00^a lnσl"^m ιn( <^ΦO (M _ιnO"f nω(M^H ωf^πΦnιnιnoDoo^^n_onιn Φι~^ιMHm^ ι^^<Λlnaι(^,) H ιnoιnoor-< ι^HmoHroo t cΛC θCM'rHσi'*<ι>HCMincDoo Ma5'f CDιn Λooσιιnr~oocoιnι cΛr-- Λoo'i^,<X)'rco ^

'V "y"- 'r'rιnιnιnιnιnιnιnιnιnιnιΛιθ u)ιnii ιθιnιπιπιntoι ιoιoι ι ι ι ιoιnιπιnιnιnιπιnιπιnιθΛi/)inιoιπ H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H ωωωωωωωωωωωωωωωωωωωωωωωωωωωcdw ooc- rt rt rt^^ ooo o ooo p. p. - - p- p,B; ι_ ι_ - o, « c_c-₎pL.p, , P, CH CH , H C ^ a; os ps s x ac ac, re

S S S < rt rtl < lH Bι lH Pι h llι Oι h EH H tι Eι E< fι EH EH H EH E H h EH E H tιtι Eι tι Eι t< EH H tι H H h H t «< Λ| < Λ; (i; tH EH tι EH EH EH EH

H CM H CM H CM H CM H CM CO CM IO CN H CM H CM H CM

O Q U N is tt m rt m o a c moD Q U HNi pQU Q awω ω N isi x ft cj o zυzz z oo o oz υoo u υcj z υ cj ocj cj u cj cj uuo z uυoυou υz u oc o cjz o o o cjo cj z cj u o cj c o z z υo o c o cj

o

CO zuuoozoυoυzϋoouυcoozoooυzuooouuozzuuoouuzuzzzouoouoozooooozuozzυooυ ro J

© a o

CΛ

H U _<M(M ΦOΦl H_'^HM^ιn(Mβι lM Φ OΦτιJlΦ^(ηco ^f no ^"l^co^"f "»HΛα)^NO DOoΦo^'*o^"^ιnιnιn^oooM

PM dP1HO^ΦOdι»l(Mc^n σιιnddo^-vιno^^-Olddn"ι^,(^,lnd"l_' ι^_"HlJι^•ιlllJlΦιιo^dM^, ln^« oιnΦΦΦ<no^d<Il^f^x(Iιωιnd ^ ^^ φlnιnΦ^p^nιM(MC lHN(MHHN^I oo^^ Φ^_coΦιn"l^ιPlΦmH^Φ n^l(M(MOHmH(^l( ιc^ιc^ln^u> ΦHHHH M "f"»^V">_"»«"r^"f"r^"T"»"f_"f*^_'»"fV"f'»nnfinoinnnnnnnnnrn"f^*'a^,vrimncirnn<Mni nn oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H I H H H H H H H , H H H H H H H H ,

N d

»

CM I

o oo o o H H dH

Φ Φ Φ Φ Φ Φ Φ Φ

H H H H H ω ω ωω ωω ωω ω ω w ωω ωω ω ω ω w w w w w ω ω w ω w wi-i w w wwω ω

D D D D D C0 C0 O U U O O CJ) CJ) U O O CJ) D D D D D D D D C0 C0 C0 C0 C0 C0 C0 C0 C0 W u ^Hqu^H3ojo^H3o^HP jι >H^Hq δrtirtrtrtrtrtSrtrtrtrt

H CM H CM H CM H CM z o u o CQ rt CQ rt CQ CJ) Q ω rt CQ rt n . Q U Sl < O UQU N S S ft CQ CJ) Q α ft BOQ Q W W ft CQ uzcjooozooooυcoozoυoozoυooooozzυoo ouozozzzocjoooocjzucjooozυυzzoooo

ooooooooooooooooooooooooooooooooooooooooooooooσooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

HHHHHHHHH HHHHHHHH,

H H CM vo o ιo r~ r~ r- σ><τι o i θ 'i' ιnn cM r- m o r-- r~ in D ' <>VD <Λ co r iO H D H io o H ι "j^, c '_' Mco -ι

VD ιn τ rθ lO r~ lO H H CM H CM ( O O O O O O O H H CN co I I I I I I I I I I I I I I I I I I I I I I σιoD CM i~ c H "*

n ιn ⁽» o ιn * ιn O "l^ι "l' oo d ^ _ ^r r• O Φ O ιn Φ ■I m d ⁽Iι H Φ m ( N ιn w lΛ eo ^f ^l d m ln co n ι)) d "f Φ " π n ιIl n ^ ιn ιJι ιn ln H ^ H Φ ^ N n o ⁽ ^l d lO ln o π ln n N lO v « (^O H Φ lB ιJι (M oo σ) ω o CD H "l^l τ o ^^l H t>^ ^ m O "f ι^| ln Φ 'f <I (Il O H ^ <Jl ln σl f1 ^ Φ d H o u⁾ ι ^ ^{( (}^ ^ π Λ ⁽n o ^ σ m σ^ o^ m ^ ^ "^ "J H < H ^^ ι ^" ^ O σl ^ "^ ⁽^ oo l ⁽J σl <D fn ^ ⁽D O H ^^, (M σι σι ιn o ^ι ι ^^, ( (M ( 0 ^(, o cM ιn ιn ι ⁾ <«^, lΛ ιn ^(,l ιn ι ⁽ l^r) Φ Φ Φ I»l d H IM O O O H H d tM I^,) IM H 9 ιn ιn Φ N N IM I^,) « H d H CJ d O H O N C>I N I^,) ^^ι m i^,l fi n "» lM tM (M d H H N O « O d φ φ φ lD Φ Φ Φ Φ V- Φ φ φ φ φ φ φ lOΦ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ løφ φ lO Φ Φ Φ Φ Φ Φ Φ lO φ φ φ φ φ lD lO φ φ lφ φ φ φ lO lD lO lO φ φ φ φ φ φ φ φ

ιnΦ^c(ιoιod ιfl^ln ^-a)Olod( n"ι^|l ^oocJιodCMπ"f ιn cM< wN(NiιriΛ(^v)ri(^riP)i*)f f^ϊιv^fl^,^iι^,"i^,ιι^,vvvιiιnuiιnιnιo HHHHHHHHHHHHHHHHHHHHHHHH— ^■ — ' — ' — ^■ — ' — ^■ — ^■ — I* _** |i "_s P — J " I " I⁴ — p "; p ^ι ^ | — r ' p — : |i — (i ^i — p — p ^i ii — |i — p — (i — p — f

oε t otH HooHotιotι toι toof footιotιoHoH Eo<to<ot<oHotιot<oEι HooH toιooeι < rt < ft < ft et < < < < ft rt ri < < < < < < < <

Table 3

ATOM 4156 N ARG E 178 63.232 11.700 -18.531 1.00 29.90 N

ATOM 4157 CA ARG E 178 63.325 12.518 -19.737 1.00 30.18 C

ATOM 4158 C ARG E 178 63.414 11.697 -21.025 1.00 30.49 C

ATOM 4159 o ARG E 178 63.956 10.585 -21.040 1.00 28.47 0

ATOM 4160 CB ARG E 178 64.544 13.443 -19.659 1.00 31.50 C TOM 4161 CG ARG E 178 64.607 14.318 -18.410 1.00 35.87 C TOM 4162 CD ARG E 178 65.695 15.381 -18.567 1.00 37.95 C

ATOM 4163 NE ARG E 178 65.438 16.174 -19.766 1.00 41.27 N

ATOM 4164 CZ ARG E 178 66.350 16.890 -20.415 1.00 42.38 C

ATOM 4165 NHl ARG E 178 67.609 16.929 -19.983 1.00 43.71 N

ATOM 4166 NH2 ARG E 178 66.007 17.545 -21.519 1.00 42.32 N

ATOM 4167 N CYS E 179 62.870 12.263 -22.102 1.00 30.09 N

ATOM 4168 CA CYS E 179 62.900 11.645 -23.415 1.00 31.40 C

ATOM 4169 C CYS E 179 63.079 12.753 -24.455 1.00 31.54 C

ATOM 4170 o CYS E 179 62.190 13.026 -25.260 1.00 30.99 0

ATOM 4171 CB CYS E 179 61.608 10.857 -23.646 1.00 32.04 C

ATOM 4172 SG CYS E 179 61.472 9.459 -22.503 1.00 33.20 S

ATOM 4173 N PRO E 180 64.253 13.412 -24.436 1.00 32.00 N

ATOM 4174 CA PRO E 180 64.578 14.504 -25.365 1.00 32.32 C

ATOM 4175 C PRO E 180 64.274 14.080 -26.789 1.00 32.64 C

ATOM 4176 o PRO E 180 64.824 13.092 -27.272 1.00 32.30 o

ATOM 4177 CB PRO E 180 66.076 14.713 -25.137 1.00 31.72 C

ATOM 4178 CG PRO E 180 66.238 14.376 -23.684 1.00 32.39 c

ATOM 4179 CD PRO E 180 65.394 13.113 -23.550 1.00 31.38 c

ATOM 4180 N ALA E 181 63.405 14.821 -27.466 1.00 33.54 N

ATOM 4181 CA ALA ε 181 63.037 14.459 -28.823 1.00 34.81 C

ATOM 4182 C ALA ε 181 63.051 15.604 -29.836 1.00 36.17 C

ATOM 4183 o ALA ε 181 62.969 16.777 -29.476 1.00 35.97 o

ATOM 4184 CB ALA ε 181 61.662 13.803 -28.806 1.00 33.94 C

ATOM 4185 N GLY ε 182 63.149 15.228 -31.109 1.00 37.42 N

ATOM 4186 CA GLY ε 182 63.141 16.184 -32.203 1.00 38.05 C

ATOM 4187 C GLY ε 182 62.107 15.728 -33.215 1.00 38.82 C

ATOM 4188 o GLY E 182 61.548 14.634 -33.076 1.00 38.84 o

ATOM 4189 N GLY E 183 61.850 16.548 -34.232 1.00 39.61 N

ATOM 4190 CA GLY E 183 60.873 16.194 -35.248 1.00 39.37 C

ATOM 4191 C GLY E 183 60.209 17.403 -35.886 1.00 40.34 C

ATOM 4192 o GLY E 183 60.126 18.472 -35.276 1.00 39.97 o

ATOM 4193 N ASN E 184 59.735 17.239 -37.118 1.00 40.45 N

ATOM 4194 CA ASN E 184 59.068 18.322 -37.835 1.00 41.60 C

ATOM 4195 C ASN E 184 57.875 17.793 -38.627 1.00 41.71 C

ATOM 4196 o ASN E 184 58.038 17.046 -39.586 1.00 42.15 o

ATOM 4197 CB ASN E 184 60.054 19.020 -38.781 1.00 41.57 C

ATOM 4198 N PRO E 185 56.657 18.206 -38.258 1.00 42.39 N

ATOM 4199 CA PRO E 185 56.348 19.132 -37.163 1.00 42.99 C

ATOM 4200 C PRO E 185 56.699 18.635 -35.758 1.00 44.39 C

ATOM 4201 o PRO E 185 56.941 17.441 -35.541 1.00 44.92 o

ATOM 4202 CB PRO E 185 54.850 19.384 -37.343 1.00 42.48 C

ATOM 4203 CG PRO ε 185 54.355 18.108 -37.914 1.00 42.87 C

ATOM 4204 CD PRO ε 185 55.424 17.771 -38.938 1.00 42.74 C

ATOM 4205 N MET E 186 56.733 19.572 -34.810 1.00 44.67 N

ATOM 4206 CA MET E 186 57.044 19.276 -33.412 1.00 44.59 C

ATOM 4207 C MET E 186 56.137 18.167 -32.883 1.00 43.62 C

ATOM 4208 o MET E 186 54.917 18.304 -32.854 1.00 43.45 o

ATOM 4209 CB MET E 186 56.861 20.533 -32.551 1.00 46.17 C

ATOM 4210 CG MET ε 186 57.269 20.364 -31.089 1.00 47.14 C

ATOM 4211 SD MET E 186 59.028 19.948 -30.944 1.00 50.88 S

ATOM 4212 CE MET E 186 59.755 21.534 -30.489 1.00 49.96 C

ATOM 4213 N PRO ε 187 56.731 17.052 -32.444 1.00 42.84 N

ATOM 4214 CA PRO ε 187 55.937 15.936 -31.925 1.00 42.11 C

ATOM 4215 C PRO ε 187 55.327 16.199 -30.551 1.00 41.39 C

ATOM 4216 o PRO ε 187 55.850 16.997 -29.771 1.00 40.66 o

ATOM 4217 CB PRO ε 187 56.945 14.789 -31.897 1.00 42.56 C

ATOM 4218 CG PRO ε 187 58.229 15.478 -31.584 1.00 42.73 C

ATOM 4219 CD PRO ε 187 58.172 16.736 -32.434 1.00 42.58 C

ATOM 4220 N THR ε 188 54.213 15.533 -30.261 1.00 40.80 N

ATOM 4221 CA THR E 188 53.570 15.694 -28.967 1.00 40.77 C Tab 3

ATOM 4222 C THR E 188 54.119 14.622 -28.039 .00 40.73 C

ATOM 4223 0 THR ε 188 54.756 13.660 -28.476 00 40.10 O

ATOM 4224 CB THR ε 188 52.042 15.522 -29.027 .00 40.84 C

ATOM 4225 OG1 THR E 188 51.728 14.136 -29.201 ,00 41.02 O

ATOM 4226 CG2 THR E 188 51.453 16.330 -30.169 ,00 40.27 C

ATOM 4227 N MET ε 189 53.867 14.791 -26.751 ,00 40.54 N

ATOM 4228 CA MET ε 189 54.345 13.841 -25.764 ,00 41.01 C

ATOM 4229 C MET E 189 53.263 13.438 -24.781 1.00 39.45 C

ATOM 4230 0 MET E 189 52.493 14.278 -24.318 00 38.97 O

ATOM 4231 CB MET ε 189 55.523 14.432 -24.982 00 42.49 C

ATOM 4232 CG MET ε 189 55.951 13.576 -23.791 00 45.02 c

ATOM 4233 SD MET E 189 57.378 14.250 -22.910 00 48.98 s

ATOM 4234 CE MET E 189 58.674 13.084 -23.501 00 48.53 c

ATOM 4235 N ARG E 190 53.222 12.146 -24.466 1.00 37.91 N

ATOM 4236 CA ARG E 190 52.264 11.603 -23.509 1.00 36.69 c

ATOM 4237 C ARG E 190 53.002 10.599 -22.625 1.00 34.83 c

ATOM 4238 o ARG E 190 53.896 9.891 -23.103 1.00 33.14 o

ATOM 4239 CB ARG E 190 51.122 10.875 -24.220 1.00 38.19 c

ATOM 4240 CG ARG E 190 50.527 11.607 -25.410 1.00 41.65 c

ATOM 4241 CD ARG E 190 49.163 11.021 -25.794 1.00 43.46 c

ATOM 4242 NE ARG E 190 49.161 9.560 -25.891 1.00 44.29 N

ATOM 4243 CZ ARG ε 190 49.719 8.866 -26.878 1.00 45.19 C

ATOM 4244 NHl ARG E 190 50.338 9.495 -27.873 1.00 46.13 N

ATOM 4245 NH2 ARG E 190 49.653 7.540 -26.874 1.00 44.60 N

ATOM 4246 N TRP E 191 52.639 10.539 -21.343 00 31.83 N

ATOM 4247 CA TRP E 191 53.269 9.586 -20.431 00 31.00 C

ATOM 4248 C TRP E 191 52.268 8.540 -19.908 00 30.76 C

ATOM 4249 o TRP E 191 51.138 8.867 -19.536 00 30.52 o

ATOM 4250 CB TRP ε 191 53.937 10.301 -19.246 00 29.62 c

ATOM 4251 CG TRP E 191 55.187 11.072 -19.603 00 28.95 c

ATOM 4252 CDl TRP E 191 55.259 12.337 -20.128 00 29.00 c

ATOM 4253 CD2 TRP ε 191 56.540 10.612 -19.487 00 28.32 c

ATOM 4254 NEl TRP ε 191 56.572 12.688 -20.344 1.00 28.22 N

ATOM 4255 CE2 TRP ε 191 57.378 11.649 -19.960 1.00 28.76 C

ATOM 4256 cε3 TRP ε 191 57.125 9.423 -19.030 1.00 29.22 C

ATOM 4257 CZ2 TRP E 191 58.775 11.533 -19.985 1.00 29.04 C

ATOM 4258 CZ3 TRP E 191 58.520 9.306 -19.060 1.00 30.17 C

ATOM 4259 CH2 TRP E 191 59.326 10.359 -19.534 1.00 29.04 c

ATOM 4260 N LEU E 192 52.687 ,280 -19.905 1.00 29.28 N

ATOM 4261 CA LEU E 192 51.840 .197 -19.421 1.00 29.58 C

ATOM 4262 C LEU E 192 52.428 .583 -18.143 1.00 29.57 C

ATOM 4263 o LEU E 192 53.645 .571 -17.958 1.00 30.74 O

ATOM 4264 CB LEU E 192 51.721 .084 -20.477 1.00 28.80 C

ATOM 4265 CG LEU E 192 51.382 ,339 -21.958 1.00 30.27 C

ATOM 4266 CDl LEU E 192 51.448 ,015 -22.708 1.00 31.01 C

ATOM 4267 CD2 LEU E 192 49.998 ,950 -22.115 1.00 29.80 c

ATOM 4268 N LYS E 193 51.559 .097 -17.260 1.00 28.96 N

ATOM 4269 CA LYS E 193 51.986 ,412 -16.051 1.00 28.34 C

ATOM 4270 C LYS E 193 51.466 ,983 -16.225 1.00 29.18 C

ATOM 4271 o LYS E 193 50.257 .763 -16.362 1.00 27.91 O

ATOM 4272 CB LYS E 193 51.371 .023 -14.794 1.00 27.85 C

ATOM 4273 CG LYS E 193 51.762 ,267 -13.506 1.00 28.13 C TOM 4274 CD LYS E 193 51.139 ,882 -12.254 1.00 29.87 C

ATOM 4275 CE LYS ε 193 51.541 ,112 -10.999 1.00 30.30 C

ATOM 4276 NZ LYS E 193 50.798 ,559 -9.789 1.00 28.18 N

ATOM 4277 N ASN E 194 52.376 .013 -16.230 1.00 28.65 N

ATOM 4278 CA ASN ε 194 51.990 ,620 -16.417 1.00 29.49 C

ATOM 4279 C ASN ε 194 51.132 0.450 -17.682 1.00 30.66 c

ATOM 4280 o ASN E 194 50.069 -0.168 -17.642 1.00 30.92 o

ATOM 4281 CB ASN E 194 51.215 0.099 -15.195 1.00 27.12 c

ATOM 4282 CG ASN E 194 52.064 0.051 -13.934 1.00 27.31 c

ATOM .4283 ODl ASN ε 194 53.271 -0.233 -13.987 1.00 25.63 o

ATOM 4284 ND2 ASN ε 194 51.433 0.310 -12.783 1.00 24.35 N TOM 4285 N GLY ε 195 51.595 1.022 -18.792 1.00 31.66 N

ATOM 4286 CA GLY ε 195 50.886 0.919 -20.060 1.00 32.64 C

ATOM 4287 C GLY ε 195 49.528 1.601 -20.206 1.00 33.77 C oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H d H H H H H H H H H H H H H H H H H H H H H H H HH H H H H H H H H H H

^lB^lO . N N σιΦ 5ιoι oo

H H H H CM CM ωωωωwwwwwωwwwwwwωωωωωωωωωωωw ϊHwωOTwwco-iOTWDDDSDDDDDωHwωωωωωpaωωww-jwwnOTWM j >ι ι ι >₎ ι >ι >ι >ι >ι j j μi j j j _lj j _h] Ϊ J! ii! ]; Ϊ J! ϊ lι' jj ϊ lι! lH >₍ >₍ >, >ι >_l >. >_{( (} j j μ| _κι μ| j j j j j j j j j j μ| ₁j j H H H H H H H H H D ι^ ι^ H3 H H^ H; H^ ιj ι-i c) ^{) )} j) θ θ c) cj⁾ cj) aι i-j ftι i-j C-ι θj a< c _ aι ι< ι-i Hi H^

H CM HH CCMM HH CCMM H CM H CM H CM H ft (O O Q IJ N rt Quaωω f O O D Q W W N ec to o a ω to rt muaww rt m o a ω ω rt CQ u a Q ω ozocjocjυυozzuc o υυooozυυoooυc cjcjuzc ϋooooυzzoυouc oozzuuoυuuoozcjcjocjuz cju

it t t tftmftf f ftf ft tft t tf f f t ft f ^ fi f f f f f fttt

oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

HHHHHHHHHHHHHHH, HHHH

O"l^| ι^,l ooιJl ιJl ln d O ωmΦ "f "t ^ "r"^y^ιnιoιn ι t ιn^ ^^ι "a^, v v "f 'rι ι ι ^ ιn tntn Ln ιn ιnι ιθι ιo ι ιoιn ^ιn ιn iniΛi ιπιθιθιn ιnιθιn ιnιo ιn

CM co ro co ro ro ro c r ro o rθ "- 'i "a 'j' 'j ']^, 'r 'r ιn ιn ιn ιn _> _> _ι _>f~ r^

O O O OO O OO O O OOO OO O OO O O OOOO OO O O O OO O O O O O O O O O O O O OO OO O OOO O O O OOH H HH H H H H H H Cl C CM CM CM CM CM CM CM CM CM CM CM CMCM CM CMCM CM CM CMC CMCM CM CM CM C CM CMCM CMCM CM CM ^ CM CM CM CM CM CM CM Cl CM W

H CM H H CM H CM H CM ω rt n ..U _ Q HN S S zzoc oouυzcjzzz c rtjtjou PQuJ⁾cJj)c Qz rtc uozc cjozuυo cQo a a ω w isi -ci < CQ O ^Q W N J CQ CJJ CJ) CQ oυouυouozuooυυυcjzzoooooυ Z O O O CJ Z U U O U

OO O OOO O OOOO O OOO EιfιHtιHtιfιt<tιt<Htιt<HH it t t^ C t ft f t f ft f ft f f f ft ftft t ft t ft ft f ft ^ ftf ft f t

zυυoozoc oozυooooυozcjυuoozcjcjouozcjc oυocjozc uooc c uzuuoυocoozυooooυoozυo

ιIι oo ιn ι Φ ιη (η (M oo d σl o o oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

ι/) _ o\ ( I ιn σ> co oθ "* <Λ oo o io co <^

O ιn ( ι^,1 ι^,) ^ι o π^ o n ιn o ιn <» ι^,l "J Φ d ι^ in "» o ι^,) (B ιn ol Φ Φ Φ Φ N N ιn " ^l O t^ d ιn o <M 'l^{, (}D ⁽ ^ ι»(^l (M H ι»l (l '» ^ σι ln O

H N H H co o oι oo oo co c ( ( H H σ> oo v co fO io r- co co σi ro cM H O

< CM CM < CM CM H H H H H H H H H H ro

o d N O * ιn ^β ^ ⁽o m o H N ⁽ M^l ιπ u ^ ιI⁾ m o H N P⁾ « ιn Φ ^ ffl Λ O H N ι^,) * ιn Φ ^ ι. ol O d N l^,l « ιn Φ ι- 9ι o N ι « ιn Φ oo oιo H ι n » ιn CM C M M CM CM C CM CM CM t r f f f fθ f ro ro r «^ ^{, ι} ι "* 'r 'r "» ιι ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn i co co ιo c^

00 rH VO

© oεεoεooεoεεoεoεoεooaoaaoaooaεoεoεooεεoaoaoaoaoaooaaoaooaoaεoεoεosoεoεoεoεoεoaoaooaaoaooεεoεooεoεaoaooaoaoaaoaooaoaaoaooεoεoεεooaoaoε O I-Jt_l3l_l_l_l_%3t3!-J _l-.^ _ _^^^^ _I_I_I-

ooozυuooυυzouoooυzυooυoozuuouozuuouuoozuuouuoυzzoυozυuouoozzoυoυuυ -β ro CJ δ

H a. oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H HH H H H H H o cD »ι^|

<M

I

o o o d d d d (M M CM N <M ( ιJl Ol

CN CN CM CN I CM CN CM CN CM CM CN CM CM CN CN CJ C CM CM O Cl C CM Cvl CJ J CM CM CM CJ M ω ωHw ω ω ωω ω ωw w ωwω ω id Hwω ia ω ω i-i ω ω l p-s oll-ipl..JH Ksppι:i βcii Plc;i l.- cl-btcinι rrtrttrrtrtrtrtrtrtrtrtrtrtpit θ< θ^j CH C w co c w co OT c ^{H H} H H 2; z a z z z z z ι: p- - S ή Cti 0- ωwwt W >H H >H >H !>H H l >H >H _l_| Hl h-l H3 C CO W C C W W CO >H >H .H H X H J.

W C0 C > >H iJ >H Hi ^pi Hi !i uι !i ji ⁽⁾; < fi; ci; d; < ⁽i; f3; H E< H H fi h ti H

H CM H CM H CM H CM

„ PO 2 ft C^Q CD U ft CQ O O rt CQ CJ) Q < CQ CD ft CQ O Q Q ft ffi U D U N ft CQ CJ) Q Q ft oυozuυouυϋzυooouυzooooouzooouozoυoc υoo CQ U Q zuυooυυυzzuυozcjooυoozzoo o u o u

Table 3

ATOM 4552 CD2 TYR ε 229 55.447 6.689 -14.306 1.00 24.93 c

ATOM 4553 CEl TYR E 229 56.521 4.954 -12.432 1.00 26.06 c

ATOM 4554 CE2 TYR E 229 54.865 6.586 -13.059 1.00 23.86 c

ATOM 4555 CZ TYR E 229 55.396 5.714 -12.126 1.00 26.06 c

ATOM 4556 OH TYR E 229 54.769 5.550 -10.912 1.00 25.94 o

ATOM 4557 N THR E 230 56.150 5.085 -19.271 1.00 25.17 N

ATOM 4558 CA THR E 230 56.454 5.151 -20.694 1.00 24.43 C

ATOM 4559 C THR E 230 56.142 6.485 -21.349 1.00 24.97 C

ATOM 4560 o THR E 230 55.070 7.064 -21.156 1.00 24.36 o

ATOM 4561 CB THR E 230 55.666 4.071 -21.457 1.00 24.48 c

ATOM 4562 OG1 THR E 230 55.930 2.795 -20.863 1.00 24.81 o

ATOM 4563 CG2 THR E 230 56.057 4.055 -22.931 1.00 22.29 c

ATOM 4564 N CYS E 231 57.086 6.963 -22.144 1.00 26.19 N

ATOM 4565 CA CYS E 231 56.899 8.212 -22.862 1.00 27.54 C

ATOM 4566 C CYS E 231 56.607 7.858 -24.317 1.00 27.22 C

ATOM 4567 o CYS ε 231 57.333 7.065 -24.916 1.00 26.23 o

ATOM 4568 CB CYS E 231 58.168 9.062 -22.783 1.00 27.82 C

ATOM 4569 SG CYS E 231 59.585 8.263 -23.576 1.00 31.09 S

ATOM 4570 N VAL E 232 55.533 8.427 -24.860 1.00 28.00 N

ATOM 4571 CA VAL E 232 55.136 8.214 -26.249 1.00 29.12 C

ATOM 4572 C VAL E 232 55.235 9.563 -26.970 1.00 29.74 C

ATOM 4573 o VAL E 232 54.641 10.541 -26.546 1.00 31.15 o

ATOM 4574 CB VAL E 232 53.693 7.700 -26.340 1.00 29.29 c

ATOM 4575 CGI VAL E 232 53.306 7.485 -27.798 1.00 28.53 c

ATOM 4576 CG2 VAL E 232 53.557 6.407 -25.549 1.00 29.10 c

ATOM 4577 N VAL E 233 56.001 9.607 -28.051 1.00 30.49 N

ATOM 4578 CA VAL ε 233 56.202 10.833 -28.807 1.00 31.77 C

ATOM 4579 C VAL ε 233 55.755 10.626 -30.254 1.00 32.47 C TOM 4580 o VAL ε 233 56.157 9.651 -30.903 1.00 32.76 o

ATOM 4581 CB VAL E 233 57.694 11.243 -28.779 1.00 31.18 C

ATOM 4582 CGI VAL E 233 57.866 12.612 -29.379 1.00 33.05 C

ATOM 4583 CG2 VAL E 233 58.199 11.250 -27.352 1.00 32.93 c

ATOM 4584 N GLU E 234 54.951 11.551 -30.773 1.00 32.15 N

ATOM 4585 CA GLU E 234 54.444 11.390 -32.129 1.00 33.60 C

ATOM 4586 C GLU E 234 54.082 12.639 -32.948 1.00 33.59 C

ATOM 4587 o GLU E 234 53.832 13.713 -32.405 1.00 33.70 o

ATOM 4588 CB GLU E 234 53.210 10.480 -32.068 1.00 33.20 c

ATOM 4589 N ASN E 235 54.068 12.460 -34.267 1.00 34.11 N

ATOM 4590 CA ASN E 235 53.657 13.483 -35.233 1.00 34.29 C

ATOM 4591 C ASN E 235 53.084 12.694 -36.411 1.00 35.08 C

ATOM 4592 o ASN E 235 52.958 11.470 -36.314 1.00 34.59 o

ATOM 4593 CB ASN E 235 54.810 14.414 -35.664 1.00 33.28 C TOM 4594 CG ASN ε 235 55.900 13.708 -36.447 1.00 33.88 c

ATOM 4595 ODl ASN ε 235 55.730 12.583 -36.910 1.00 33.30 o

ATOM 4596 ND2 ASN ε 235 57.036 14.385 -36.609 1.00 34.18 N

ATOM 4597 N GLU ε 236 52.738 13.358 -37.512 1.00 36.42 N

ATOM 4598 CA GLU E 236 52.138 12.629 -38.636 1.00 38.00 C

ATOM 4599 C GLU E 236 53.011 11.594 -39.343 1.00 37.78 C

ATOM 4600 o GLU E 236 52.486 10.739 -40.053 1.00 37.97 o

ATOM 4601 CB GLU E 236 51.531 13.595 -39.664 1.00 40.24 C

ATOM 4602 CG GLU ε 236 52.492 14.582 -40.284 1.00 43.86 C

ATOM 4603 CD GLU E 236 51.790 15.531 -41.242 1.00 46.25 C

ATOM 4604 OEl GLU ε 236 51.225 15.059 -42.255 1.00 47.28 o

ATOM 4605 OE2 GLU ε 236 51.803 16.750 -40.976 1.00 47.49 o

ATOM 4606 N TYR E 237 54.323 11.640 -39.121 1.00 37.33 N

ATOM 4607 CA TYR ε 237 55.242 10.708 -39.766 1.00 37.35 c

ATOM 4608 C TYR ε 237 55.754 9.569 -38.867 1.00 35.98 c

ATOM 4609 o TYR ε 237 56.577 8.758 -39.290 1.00 35.90 o

ATOM 4610 CB TYR ε 237 56.415 11.508 -40.346 1.00 38.92 c

ATOM 4611 CG TYR E 237 55.957 12.649 -41.233 1.00 41.25 c

ATOM 4612 CDl TYR E 237 56.460 13.943 -41.059 1.00 43.19 c

ATOM 4613 CD2 TYR E 237 55.004 12.444 -42.226 1.00 42.47 c

ATOM 4614 cεi TYR E 237 56.018 15.008 -41.855 1.00 44.62 c

ATOM 4615 cε2 TYR E 237 54.554 13.495 -43.026 1.00 44.57 c

ATOM 4616 CZ TYR E 237 55.062 14.777 -42.835 1.00 45.49 c

ATOM 4617 OH TYR E 237 54.598 15.822 -43.609 1.00 46.29 o Table 3

ATOM 4618 N GLY E 238 55.275 9.497 -37.632 1.00 34.97 N

ATOM 4619 CA GLY E 238 55.731 8.417 -36.777 1.00 33.97 . C

ATOM 4620 C GLY E 238 55.405 8.507 -35.303 1.00 33.08 c

ATOM 4621 o GLY E 238 54.983 9.548 -34.803 1.00 32.50 o

ATOM 4622 N sεR E 239 55.617 7.390 -34.612 1.00 32.34 N

ATOM 4623 CA SER E 239 55.369 7.282 -33.181 1.00 31.81 C

ATOM 4624 C sεR E 239 56.404 6.351 -32.543 1.00 30.71 C

ATOM 4625 o SER E 239 56.567 5.211 -32.980 1.00 30.65 o

ATOM 4626 CB SER E 239 53.954 6.739 -32.942 1.00 30.90 C

ATOM 4627 OG SER E 239 53.628 6.735 -31.563 1.00 33.07 o

ATOM 4628 N ILE E 240 57.091 6.834 -31.510 1.00 29.56 N

ATOM 4629 CA ILE ε 240 58.112 6.042 -30.827 1.00 28.65 C

ATOM 4630 C ILE ε 240 57.935 6.162 -29.318 1.00 28.96 C

ATOM 4631 o ILE ε 240 57.382 7.152 -28.830 1.00 30.00 . o

ATOM 4632 CB ILE ε 240 59.528 6.514 -31.210 1.00 28.14 C

ATOM 4633 CGI ILE ε 240 59.726 7.960 -30.758 1.00 28.72 C

ATOM 4634 CG2 ILE E 240 59.712 6.435 -32.729 1.00 26.24 C

ATOM 4635 CDl ILE E 240 61.132 8.520 -31.032 1.00 29.86 C

ATOM 4636 N ASN E 241 58.405 5.157 -28.582 1.00 27.76 N

ATOM 4637 CA ASN ε 241 58.284 5.147 -27.136 1.00 26.27 C

ATOM 4638 C ASN E 241 59.499 4.531 -26.439 1.00 26.41 C

ATOM 4639 o ASN E 241 60.301 3.815 -27.058 1.00 25.18 o

ATOM 4640 CB ASN E 241 57.018 4.384 -26.711 1.00 25.29 C

ATOM 4641 CG ASN E 241 56.946 2.983 -27.311 1.00 27.08 C

ATOM 4642 ODl ASN ε 241 56.345 2.769 -28.374 1.00 29.98 o

ATOM 4643 ND2 ASN ε 241 57.578 2.032 -26.652 1.00 26.55 N

ATOM 4644 N HIS E 242 59.610 4.819 -25.145 1.00 26.04 N

ATOM 4645 CA HIS ε 242 60.693 4.317 -24.309 1.00 27.09 C

ATOM 4646 C HIS E 242 60.130 4.097 -22.913 1.00 26.68 C

ATOM 4647 o HIS E 242 59.274 4.865 -22.464 1.00 26.32 o

ATOM 4648 CB HIS E 242 61.833 5.325 -24.233 1.00 28.10 C TOM 4649 CG HIS E 242 62.957 4.888 -23.352 1.00 29.54 C

ATOM 4650 ND1 HIS E 242 63.851 3.904 -23.716 1.00 30.25 N

ATOM 4651 CD2 HIS E 242 63.341 5.309 -22.124 1.00 31.00 C

ATOM 4652 CEl HIS E 242 64.742 3.744 -22.754 1.00 32.05 C

ATOM 4653 NE2 HIS ε 242 64.455 4.585 -21.778 1.00 32.16 N

ATOM 4654 N THR ε 243 60.617 3.068 -22.225 1.00 26.12 N

ATOM 4655 CA THR ε 243 60.112 2.759 -20.893 1.00 26.90 C

ATOM 4656 C THR E 243 61.134 2.756 -19.770 1.00 27.39 C

ATOM 4657 o THR E 243 62.219 2.202 -19.908 1.00 27.23 o

ATOM 4658 CB THR E 243 59.377 1.381 -20.871 1.00 26.77 C

ATOM 4659 OG1 THR E 243 58.225 1.439 -21.716 1.00 25.38 o

ATOM 4660 CG2 THR E 243 58.917 1.032 -19.449 1.00 26.06 C

ATOM 4661 N TYR E 244 60.757 3.390 -18.662 1.00 27.91 N

ATOM 4662 CA TYR ε 244 61.581 3.460 -17.465 1.00 29.32 C

ATOM 4663 C TYR ε 244 60.898 2.640 -16.370 1.00 30.85 C

ATOM 4664 o TYR E 244 59.677 2.506 -16.354 1.00 30.71 o

ATOM 4665 CB TYR E 244 61.723 4.899 -16.960 1.00 27.74 C

ATOM 4666 CG TYR E 244 62.566 5.802 -17.828 1.00 27.95 C

ATOM 4667 CDl TYR ε 244 61.987 6.840 -18.564 1.00 26.62 C

ATOM 4668 CD2 TYR ε 244 63.951 5.640 -17.888 1.00 26.74 C

ATOM 4669 CEl TYR ε 244 62.769 7.696 -19.334 1.00 27.44 C

ATOM 4670 CE2 TYR ε 244 64.739 6.481 -18.651 1.00 27.77 C

ATOM 4671 CZ TYR ε 244 64.147 7.511 -19.371 1.00 28.12 C

ATOM 4672 OH TYR ε 244 64.943 8.350 -20.107 1.00 27.83 o

ATOM 4673 N HIS ε 245 61.693 2.088 -15.464 1.00 31.97 N

ATOM 4674 CA HIS ε 245 61.161 1.322 -14.349 1.00 33.12 C

ATOM 4675 C HIS E 245 61.552 2.073 -13.083 1.00 33.00 C

ATOM 4676 o HIS E 245 62.706 2.472 -12.929 1.00 32.70 o

ATOM 4677 CB HIS E 245 61.760 -0.085 -14.341 1.00 34.97 C

ATOM 4678 CG HIS E 245 61.552 -0.826 -15.629 1.00 37.68 C

ATOM 4679 ND1 HIS ε 245 60.342 -1.378 -15.982 1.00 38.21 N

ATOM 4680 CD2 HIS ε 245 62.396 -1.081 -16.657 1.00 39.69 C

ATOM 4681 CEl HIS ε 245 60.444 -1.941 -17.175 1.00 38.71 C

ATOM 4682 NE2 HIS ε 245 61.684 -1.772 -17.607 1.00 39.57 N

ATOM 4683 N Lεu ε 246 60.594 2.292 -12.190 1.00 32.23 N ooouυuυzoυooυoozocjoooozυooucjozuuoooυoozc oouoozozzzooooozuoououzooo _ ro CJ

© a _ ©

CΛ

H _<^ o»o^o^_{l d}vlBOι<ιoooooιn^ddooO( < O^r>Nιnd<l'P) ^01^'(ONdπι codιonιIl0^ιo^(MN«nfl90lo5looι ιo»NOll ^ι _H ιor "_{J O}<_{Λ Φ} ι^ro(_{M N}^co v_{H l d}ιo^ιnr_^ι^_{H CM}^^_" ^Φ^_Λ ^^l_O ωcoσtH<n^(Dr_"CDd^^,σ)HH^f _M^O"^^,^^,^^,ooolnσ σ) l-H

_N(_θ"»o\α)t "rw Φr-oιom i~ inΦιnιn iniΛinιnΦ^ Φoιncorⁱt_^ι "»ιnΦ< θooιn^vιnιnωΦιθ oiΦr t^ror~r_" r~ ι ιθ c ro(o<_MC C>j Mcoro(^c ( r ro<oc rororo(orθ(or ( ( <o<or fθf c ι Plι 'r '^ c f ro oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H_HHHHHHHH H_HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH

_Hi_D-'_f in_Nin^_flH^oiovnc 'i'iΛ _HinΦiΛindomoooi_NΦnmmndiMino eoωiniiinn'rwdhvσiHONNONmi inmiΛN

ωωωωωωwωωωωωωωωωωwwwwwωωωωωωωωw

DDD3DD_ Bι0ι0ιDι& DιPι ιJJ JJJJ JJ ιJ ιJ J j μiDDDaDDDDDUC5OO 5 5ϋl5U UC5 (ϊ;aill! |ϊ;«

_ ω a tι) ω wH ffi m onn iΛ ( ϋ) ra .rtrtrtrtrtrtrtrtrtrtrtrtrtH^H H^jH^HqHPHΪHi ήKΛrtKpήoHcζpcjpήαω μi ₍ ^j ,_^| ₍-1₁_l _φ_I J rt rt rt rt rt rt rt rt > > > > > > > > > > > > > > U C5 c5 UC5 O C3 U O S S ^ iϊ 3 S 533κ⁾n c W 0) W llι C- l- Ilι C- llι 0ι X K E Ϊi

H CM H CM HCM HCM H CM H CM rt CQ CJ) O Q ft o a a < CQ CJ) CJ) rt PQ O CD rt CQ U) Q W W rt n U Q U N X X ft CQ CJ) rt Q CD Q uuoυoooz uυocjuooz CJ CJ O CJ CJ O Z CJ CJ O CJ O CJ Z U O O CJ O O O O Z O CJ O O O CJ Z U Z Z Z CJ O O CJ O Z U CJ O CJ O O z υ CJ o

oooooooooooooooooooooooooooooooooooooooooooooooooooooooooσoooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo β w H ^ι o "^ "^ Φ O ^ σι σι s^, <l^ι >^ ιO ln "a' ι d m 90^ ιn (n ^ι r^ ^ om o v "J d (M ιn ^ <Il N ln ιJι ιIJ H O d (M ^ lIl ^ ^ <^,) o> O ιn l- ^ oo<^ H ω ιn ιn o ιn o n l Φ Oι ιJl « ln ι <Λ <J ιn ^ ιn rt ^ o co "^ o ^ι m (M l ι n n ro ω Φ ιn o Φ n ^ n n ^ « ln ι ^1 co ol l Φ n ol ^ (η ιn Φ l Φ "f ιn eι> Φ 05 ιn «f (o ιn o ιn ιn βm n "f m ^ oo σι o H c^ ιπ<Λ ^ H N O <)l m "^ "f lJ^ <f _ o σl ID ιn n (D n o ι r" ιn 'ιι ln ol n <Λ « d "|^l H "lι o d Φ Φ '* <Il n m ιη W 7 N n ln ln ιn ιn Φ ^ ιJ o o m H ln ιιl ^ ι» Φ ιn ιn Φ ^ _ r• r• Φ ^' Φ lΛ lJ^ o o H O d » o o N n o o o m d ^M ^^ 1l^ι <f « Φ ιn ιn ιn <ι^| ι^,) ι»l d v

H H H H H H H H H H H H H CM CM H CM H H H H H H H H H H H H H H H H H CM rsl c c CM H Cg C cM CI CM CM CM H CM CM <M CM CM CM CM CM CM CNl CM CM CM CM CM CM CM CM

H ιn _ ii n ω m « oo N Φ O φ ιn ιn ιn "f Hf m o o d O o m (. oo co o o ω <Il d ^l N ^ Φ Φ Φ ιn ιn M' <^ Φ Φ ln v ^ _ ιI\ ^ι "r ι<ι p| Hl^, < d d H O N ι d d O N ^ι n n » ιn ι- ι» ιn » n 1l^, ΦΦ Φi^ r^ r- r- Φ Φ r^ h' Φ r^>- r^ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ

o o z o o .. z z . c oou υ υz υzz z cjc o u υcj z c cj o cj c c o zuυooυoozocj o ucjo z z c u o c z cj cjo z υcjoυ c cjo

Table 3

ATOM 4816 N PRO E 263 67.835 -9.794 25.690 1.00 36.61 N

ATOM 4817 CA PRO E 263 67.751 -11.144 26.256 1.00 36.99 C

ATOM 4818 C PRO E 263 66.947 -11.202 27.552 1.00 37.76 C

ATOM 4819 0 PRO E 263 66.684 -10.180 28.181 1.00 37.69 o

ATOM 4820 CB PRO E 263 69.216 -11.505 26.464 1.00 37.44 C

ATOM 4821 CG PRO E 263 69.809 -10.185 26.849 1.00 36.22 C

ATOM 4822 CD PRO E 263 69.197 -9.254 25.830 1.00 36.32 C

ATOM 4823 N ALA E 264 66.561 -12.406 27.949 1.00 39.07 N

ATOM 4824 CA ALA ε 264 65.789 -12.588 29.173 1.00 40.24 C

ATOM 4825 C ALA E 264 66.647 -13.176 30.284 1.00 40.74 C

ATOM 4826 o ALA E 264 67.602 -13.911 30.024 1.00 40.98 o

ATOM 4827 CB ALA E 264 64.586 -13.497 28.905 1.00 40.12 C

ATOM 4828 N ASN ε 265 66.308 -12.833 31.523 1.00 42.19 N

ATOM 4829 CA ASN E 265 67.027 -13.352 32.680 1.00 43.62 C

ATOM 4830 C ASN E 265 66.936 -14.880 32.650 1.00 44.58 C

ATOM 4831 o ASN E 265 65.966 -15.445 32.124 1.00 44.42 o

ATOM 4832 CB ASN ε 265 66.399 -12.817 33.969 1.00 44.05 C

ATOM 4833 CG ASN E 265 67.055 -11.536 34.456 1.00 45.16 C

ATOM 4834 ODl ASN E 265 67.185 -10.557 33.718 1.00 44.14 o

ATOM 4835 ND2 ASN E 265 67.471 -11.540 35.716 1.00 46.55 N

ATOM 4836 N ALA E 266 67.947 -15.545 33.198 1.00 45.09 N

ATOM 4837 CA ALA E 266 67.955 -17.004 33.230 1.00 46.13 C

ATOM 4838 C ALA E 266 68.539 -17.506 34.545 1.00 46.86 C

ATOM 4839 o ALA E 266 69.381 -16.842 35.162 1.00 46.71 o

ATOM 4840 CB ALA E 266 68.750 -17.556 32.046 1.00 45.45 C

ATOM 4841 N SER E 267 68.077 -18.679 34.971 1.00 47.77 N

ATOM 4842 CA SER E 267 68.538 -19.290 36.212 1.00 48.84 C

ATOM 4843 C SER E 267 68.774 -20.781 35.989 1.00 49.84 C

ATOM 4844 o SER ε 267 68.054 -21.425 35.214 1.00 50.77 o

ATOM 4845 CB SER ε 267 67.502 -19.090 37.323 1.00 48.70 C

ATOM 4846 N ASP E 273 72.922 -25.916 31.411 1.00 52.50 N

ATOM 4847 CA ASP E 273 73.121 -25.160 30.177 1.00 52.79 C

ATOM 4848 C ASP E 273 72.109 -24.024 30.024 1.00 52.36 C TOM 4849 o ASP E 273 70.968 -24.115 30.493 1.00 52.76 o

ATOM 4850 CB ASP E 273 73.069 -26.097 28.964 1.00 53.36 C

ATOM 4851 CG ASP E 273 74.391 -26.816 28.729 1.00 53.74 C

ATOM 4852 ODl ASP E 273 75.031 -27.208 29.723 1.00 54.01 o

ATOM 4853 OD2 ASP E 273 74.786 -26.998 27.557 1.00 53.01 o

ATOM 4854 N VAL E 274 72.535 -22.949 29.367 1.00 51.31 N

ATOM 4855 CA VAL E 274 71.671 -21.785 29.182 1.00 50.20 C

ATOM 4856 C VAL E 274 71.954 -21.011 27.891 1.00 49.58 c

ATOM 4857 0 VAL E 274 72.997 -21.178 27.255 1.00 49.28 o

ATOM 4858 CB VAL E 274 71.830 -20.800 30.366 1.00 49.84 c

ATOM 4859 CGI VAL E 274 73.191 -20.125 30.298 1.00 49.41 c

ATOM 4860 CG2 VAL E 274 70.720 -19.770 30.349 1.00 50.22 c

ATOM 4861 N GLU E 275 71.010 -20.159 27.509 1.00 48.78 N

ATOM 4862 CA GLU E 275 71.183 -19.335 26.329 1.00 47.91 C

ATOM 4863 C GLU E 275 70.564 -17.960 26.526 1.00 46.62 c

ATOM 4864 o GLU E 275 69.689 -17.765 27.368 1.00 46.91 o

ATOM 4865 CB GLU E 275 70.570 -19.993 25.099 1.00 48.23 c

ATOM 4866 CG GLU E 275 69.073 -20.101 25.150 1.00 49.42 c

ATOM 4867 CD GLU ε 275 68.487 -20.457 23.802 1.00 50.68 c

ATOM 4868 OEl GLU E 275 69.158 -21.191 23.039 1.00 51.67 o

ATOM 4869 OE2 GLU E 275 67.356 -20.011 23.510 1.00 51.40 o

ATOM 4870 N PHE E 276 71.051 -17.005 25.746 1.00 44.96 N

ATOM 4871 CA PHE E 276 70.557 -15.642 25.781 1.00 43.18 C

ATOM 4872 C PHε E 276 70.298 -15.259 24.342 1.00 42.01 C

ATOM 4873 o PHε E 276 71.174 -15.394 23.488 1.00 41.08 o

ATOM 4874 CB PHε E 276 71.595 -14.715 26.398 1.00 44.88 c

ATOM 4875 CG PHε E 276 71.764 -14.901 27.878 1.00 46.37 c

ATOM 4876 CDl PHE E 276 70.721 -14.605 28.749 1.00 46.80 c

ATOM 4877 CD2 PHE E 276 72.977 -15.350 28.402 1.00 46.66 c

ATOM 4878 CEl PHE E 276 70.883 -14.749 30.129 1.00 48.86 c

ATOM 4879 CE2 PHE E 276 73.154 -15.499 29.775 1.00 48.80 c

ATOM 4880 CZ PHE E 276 72.104 -15.198 30.648 1.00 48.50 c

ATOM 4881 N VAL E 277 69.084 -14.799 24.072 1.00 40.85 N Table 3

ATOM 4882 CA VAL E 277 68.710 -14.420 22.722 1.00 40.07 c

ATOM 4883 C VAL E 277 68.559 -12.922 22.573 1.00 39.63 c

ATOM 4884 0 VAL ε 277 68.187 -12.216 23.512 1.00 40.44 o TOM 4885 CB VAL ε 277 67.393 -15.087 22.303 1.00 39.97 c

ATOM 4886 CGI VAL ε 277 67.072 -14.742 20.862 1.00 39.49 c

ATOM 4887 CG2 VAL E 277 67.503 -16.591 22.484 1.00 40.06 c

ATOM 4888 N CYS E 278 68.850 -12.438 21.376 1.00 38.95 N

ATOM 4889 CA CYS E 278 68.744 -11.023 21.092 1.00 38.48 C

ATOM 4890 C CYS E 278 68.168 -10.848 19.694 1.00 37.35 C

ATOM 4891 o CYS E 278 68.469 -11.642 18.809 1.00 37.61 o

ATOM 4892 CB CYS E 278 70.122 -10.375 21.170 1.00 39.85 C

ATOM 4893 SG CYS E 278 70.048 -8.589 21.045 1.00 44.17 s

ATOM 4894 N LYS E 279 67.334 -9.825 19.506 1.00 35.62 N

ATOM 4895 CA LYS E 279 66.729 -9.538 18.198 1.00 34.29 C

ATOM 4896 C LYS E 279 66.988 -8.093 17.770 1.00 33.03 C TOM 4897 o LYS ε 279 66.437 -7.149 18.356 1.00 31.92 o

ATOM 4898 CB LYS ε 279 65.214 -9.788 18.220 1.00 34.84 C

ATOM 4899 CG LYS E 279 64.798 -11.190 17.806 1.00 37.35 c

ATOM 4900 CD LYS E 279 65.191 -11.495 16.349 1.00 37.45 c

ATOM 4901 CE LYS E 279 64.485 -10.561 15.370 1.00 38.22 c

ATOM 4902 NZ LYS E 279 64.821 -10.836 13.944 1.00 36.90 N

ATOM 4903 N VAL E 280 67.799 -7.933 16.727 1.00 31.70 N

ATOM 4904 CA VAL E 280 68.179 -6.614 16.223 1.00 30.63 C

ATOM 4905 C VAL E 280 67.595 -6.185 14.877 1.00 30.67 C

ATOM 4906 o VAL E 280 67.388 -7.000 13.972 1.00 30.96 o

ATOM 4907 CB VAL ε 280 69.721 -6.510 16.128 1.00 31.01 C

ATOM 4908 CGI VAL E 280 70.128 -5.143 15.601 1.00 30.63 C

ATOM 4909 CG2 VAL E 280 70.344 -6.785 17.501 1.00 30.60 C

ATOM 4910 N TYR E 281 67.340 -4.883 14.758 1.00 30.41 N

ATOM 4911 CA TYR E 281 66.812 -4.277 13.534 1.00 30.43 C

ATOM 4912 C TYR E 281 67.654 -3.033 13.214 1.00 29.51 C

ATOM 4913 o TYR ε 281 67.939 -2.232 14.101 1.00 30.49 o

ATOM 4914 CB TYR ε 281 65.341 -3.885 13.726 1.00 30.72 C

ATOM 4915 N SER E 282 68.059 -2.881 11.959 1.00 28.51 N

ATOM 4916 CA SER E 282 68.873 -1.743 11.541 1.00 28.49 C

ATOM 4917 C SER ε 282 68.981 -1.649 10.016 1.00 28.34 C

ATOM 4918 o SER E 282 68.990 -2.670 9.335 1.00 28.39 o

ATOM 4919 CB SER E 282 70.276 -1.872 12.144 1.00 28.98 C

ATOM 4920 OG SER ε 282 71.129 -0.841 11.680 1.00 27.93 o

ATOM 4921 N ASP E 283 69.053 -0.425 9.489 1.00 28.16 N

ATOM 4922 CA ASP E 283 69.186 -0.203 8.043 1.00 27.48 C

ATOM 4923 C ASP E 283 70.686 -0.255 7.763 1.00 27.69 C

ATOM 4924 o ASP E 283 71.153 -1.114 7.020 1.00 27.69 o

ATOM 4925 CB ASP E 283 68.635 1.173 7.652 1.00 27.30 C

ATOM 4926 CG ASP E 283 68.615 1.398 6.138 1.00 26.87 C

ATOM 4927 ODl ASP E 283 69.363 0.720 5.396 1.00 26.10 o

ATOM 4928 OD2 ASP E 283 67.847 2.276 5.689 1.00 26.11 o

ATOM 4929 N ALA E 284 71.432 0.671 8.363 1.00 26.91 N

ATOM 4930 CA ALA E 284 72.885 0.684 8.230 1.00 27.55 c

ATOM 4931 C ALA ε 284 73.342 -0.636 8.860 1.00 27.06 c TOM 4932 o ALA ε 284 72.814 -1.034 9.903 1.00 26.87 o

ATOM 4933 CB ALA E 284 73.485 1.859 9.011 1.00 26.70 c

ATOM 4934 N GLN ε 285 74.303 -1.320 8.241 1.00 26.18 N

ATOM 4935 CA GLN ε 285 74.783 -2.598 8.807 1.00 26.17 C

ATOM 4936 C GLN E 285 75.162 -2.456 10.277 1.00 25.13 c

ATOM 4937 o GLN E 285 75.998 -1.627 10.636 1.00 25.37 o

ATOM 4938 CB GLN E 285 76.004 -3.168 8.062 1.00 26.14 c

ATOM 4939 CG GLN E 285 75.734 -3.808 6.714 1.00 27.73 c

ATOM 4940 CD GLN E 285 74.706 -4.913 6.765 1.00 27.55 c

ATOM 4941 OEl GLN E 285 73.663 -4.815 6.136 1.00 29.93 o

ATOM 4942 NE2 GLN ε 285 74.992 -5.973 7.516 1.00 29.65 N

ATOM 4943 N PRO E 286 74.543 -3.274 11.141 1.00 24.69 N

ATOM 4944 CA PRO E 286 74.825 -3.245 12.580 1.00 25.25 C

ATOM 4945 C PRO E 286 75.918 -4.237 12.992 1.00 25.84 C

ATOM 4946 o PRO E 286 76.096 -5.270 12.359 1.00 27.46 o

ATOM 4947 CB PRO E 286 73.467 -3.605 13.181 1.00 24.49 C Tab

ATOM 4948 CG PRO E 286 72.960 -4.655 12.225 1.00 23.95 c

ATOM 4949 CD PRO E 286 73.349 -4.085 10.851 1.00 24.51 c

ATOM 4950 N HIS E 287 76.654 -3.911 14.052 1.00 26.68 N

ATOM 4951 CA HIS E 287 77.702 -4.786 14.571 1.00 27.28 C

ATOM 4952 C HIS E 287 77.250 -5.261 15.950 1.00 27.80 C

ATOM 4953 0 HIS E 287 77.062 -4.458 16.868 1.00 27.59 o

ATOM 4954 CB HIS E 287 79.044 -4.055 14.680 1.00 27.34 C

ATOM 4955 CG HIS E 287 80.167 -4.937 15.139 1.00 28.97 C

ATOM 4956 ND1 HIS E 287 80.689 -4.880 16.416 1.00 29.15 N

ATOM 4957 CD2 HIS E 287 80.832 -5.935 14.506 1.00 28.29 C

ATOM 4958 cεi HIS E 287 81.625 -5.803 16.551 1.00 29.45 C

ATOM 4959 Nε2 HIS E 287 81.731 -6.459 15.406 1.00 29.06 N

ATOM 4960 N ILE E 288 77.061 -6.570 16.081 1.00 28.01 N

ATOM 4961 CA ILE E 288 76.584 -7.159 17.323 1.00 29.20 C

ATOM 4962 c ILE ε 288 77.650 -7.931 18.104 1.00 30.30 C

ATOM 4963 o ILE ε 288 78.469 -8.645 17.521 1.00 31.71 o

ATOM 4964 CB ILE E 288 75.385 -8.087 17.018 1.00 27.76 c

ATOM 4965 CGI ILE E 288 74.285 -7.278 16.316 1.00 28.76 c

ATOM 4966 CG2 ILE ε 288 74.850 -8.717 18.290 1.00 27.88 c

ATOM 4967 CDl ILE E 288 73.227 -8.141 15.623 1.00 25.74 c

ATOM 4968 N GLN ε 289 77.641 -7.771 19.426 1.00 31.39 N

ATOM 4969 CA GLN E 289 78.580 -8.475 20.292 1.00 33.14 c

ATOM 4970 C GLN E 289 77.924 -8.769 21.633 1.00 33.52 c

ATOM 4971 o GLN ε 289 76.961 -8.102 22.018 1.00 34.50 o

ATOM 4972 CB GLN ε 289 79.861 -7.650 20.495 1.00 34.53 c

ATOM 4973 CG GLN ε 289 79.655 -6.240 21.025 1.00 35.38 c

ATOM 4974 CD GLN E 289 80.970 -5.538 21.279 1.00 37.44 c

ATOM 4975 OEl GLN E 289 81.851 -6.087 21.938 1.00 39.19 o

ATOM 4976 NE2 GLN E 289 81.113 -4.319 20.765 1.00 37.44 N

ATOM 4977 N TRP ε 290 78.425 -9.789 22.323 1.00 33.78 N

ATOM 4978 CA TRP E 290 77.902 -10.171 23.628 1.00 34.30 C

ATOM 4979 C TRP E 290 78.965 -9.867 24.670 1.00 35.91 C

ATOM 4980 o TRP E 290 80.131 -10.253 24.515 1.00 36.39 o

ATOM 4981 CB TRP E 290 77.537 -11.663 23.669 1.00 32.84 C

ATOM 4982 CG TRP E 290 76.254 -12.011 22.953 1.00 31.62 C

ATOM 4983 CDl TRP E 290 76.120 -12.430 21.659 1.00 32.53 C

ATOM 4984 CD2 TRP E 290 74.931 -11.985 23.503 1.00 30.60 C

ATOM 4985 NEl TRP E 290 74.796 -12.673 21.369 1.00 30.76 N

ATOM 4986 CE2 TRP E 290 74.045 -12.406 22.484 1.00 31.02 C

ATOM 4987 CE3 TRP E 290 74.406 -11.644 24.757 1.00 30.73 C

ATOM 4988 CZ2 TRP E 290 72.661 -12.497 22.680 1.00 30.30 C

ATOM 4989 CZ3 TRP ε 290 73.029 -11.736 24.955 1.00 30.32 C

ATOM 4990 CH2 TRP ε 290 72.173 -12.159 23.918 1.00 31.09 C

ATOM 4991 N ILE ε 291 78.561 -9.176 25.731 1.00 37.47 N

ATOM 4992 CA ILE E 291 79.487 -8.787 26.785 1.00 39.92 C

ATOM 4993 C ILE ε 291 79.075 -9.239 28.185 1.00 41.83 C

ATOM 4994 o ILE ε 291 77.892 -9.260 28.529 1.00 41.92 o

ATOM 4995 CB ILE E 291 79.658 -7.263 26.808 1.00 39.84 C

ATOM 4996 CGI ILE ε 291 80.151 -6.777 25.442 1.00 39.98 C

ATOM 4997 CG2 ILE E 291 80.619 -6.867 27.912 1.00 39.95 C

ATOM 4998 CDl ILE E 291 80.132 -5.274 25.295 1.00 40.10 C

ATOM 4999 N LYS E 292 80.073 -9.601 28.988 1.00 43.20 N

ATOM 5000 CA LYS E 292 79.856 -10.022 30.366 1.00 44.66 C

ATOM 5001 C LYS ε 292 80.471 -8.948 31.251 1.00 45.75 C

ATOM 5002 o LYS E 292 81.609 -8.523 31.028 1.00 45.37 o TOM 5003 CB LYS E 292 80.536 -11.-362 30.649 1.00 44.86 C TOM 5004 N HIS ε 293 79.714 -8.506 32.250 1.00 47.10 N

ATOM 5005 CA HIS E 293 80.183 -7.476 33.167 1.00 48.94 C

ATOM 5006 C HIS E 293 81.057 -8.107 34.242 1.00 50.05 C

ATOM 5007 o HIS E 293 80.555 -8.806 35.125 1.00 50.26 o

ATOM 5008 CB HIS ε 293 78.988 -6.768 33.816 1.00 48.54 C

ATOM 5009 N VAL ε 294 82.363 -7.861 34.155 1.00 51.57 N

ATOM 5010 CA VAL E 294 83.319 -8.401 35.115 1.00 53.36 C

ATOM 5011 C VAL E 294 83.961 -7.281 35.930 1.00 54.68 C

ATOM 5012 o VAL E 294 84.546 -7.524 36.986 1.00 56.28 o

ATOM 5013 CB VAL E 294 84.436 -9.201 34.407 1.00 53.01 C Table 3

ATOM 5014 N PRO E 307 83.804 0.595 34.001 1.00 60.83 N

ATOM 5015 CA PRO ε 307 83.190 -0.739 34.037 1.00 60.46 C

ATOM 5016 C PRO ε 307 84.063 -1.813 33.386 1.00 59.98 C

ATOM 5017 0 PRO E 307 84.386 -1.725 32.199 1.00 60.20 O

ATOM 5018 CB PRO E 307 81.880 530 33.280 1.00 60.75 C

ATOM 5019 CG PRO E 307 82.275 476 32.231 1.00 60.65 C

ATOM 5020 CD PRO E 307 83.107 468 33.037 1.00 61.05 C

ATOM 5021 N TYR E 308 84.441 822 34.166 1.00 58.80 N TOM 5022 CA TYR E 308 85.266 -3.917 33.655 1.00 57.71 C

ATOM 5023 C TYR E 308 84.411 -4.844 32.796 1.00 56.51 C

ATOM 5024 o TYR E 308 83.524 -5.533 33.301 1.00 57.08 O

ATOM 5025 CB TYR E 308 85.887 -4.707 34.815 1.00 57.74 c

ATOM 5026 N LEU E 309 84.689 -4.865 31.497 1.00 55.13 N

ATOM 5027 CA LEU E 309 83.926 -5.690 30.570 1.00 53.60 C

ATOM 5028 C LEU E 309 84.771 -6.784 29.916 1.00 52.13 C

ATOM 5029 o LEU E 309 85.991 -6.664 29.813 1.00 52.33 O

ATOM 5030 CB LEU E 309 83.313 -4.788 29.496 1.00 53.76 C

ATOM 5031 CG LEU E 309 82.632 -3.528 30.042 1.00 54.69 C

ATOM 5032 CDl Lεu ε 309 82.231 -2.615 28.886 1.00 55.37 C

ATOM 5033 CD2 LEU E 309 81.426 -3.910 30.889 1.00 54.17 c

ATOM 5034 N LYS ε 310 84.111 -7.852 29.483 1.00 49.92 N

ATOM 5035 CA LYS E 310 84.784 -8.963 28.812 1.00 47.92 C

ATOM 5036 C LYS E 310 83.957 -9.383 27.596 1.00 46.18 C

ATOM 5037 o LYS E 310 82.791 -9.760 27.733 1.00 45.41 O

ATOM 5038 CB LYS ε 310 84.934 -10.151 29.766 1.00 47.80 C

ATOM 5039 N VAL E 311 84.561 -9.321 26.412 1.00 44.53 N

ATOM 5040 CA VAL E 311 83.864 -9.690 25.178 1.00 42.94 C

ATOM 5041 C VAL ε 311 83.812 -11.197 24.979 1.00 42.70 C

ATOM 5042 o VAL ε 311 84.837 -11.841 24.753 1.00 43.13 O

ATOM 5043 CB VAL ε 311 84.539 -9.071 23.934 1.00 42.45 C

ATOM 5044 CGI VAL ε 311 83.833 -9.550 22.661 1.00 40.98 C

ATOM 5045 CG2 VAL ε 311 84.511 -7.557 24.029 1.00 41.52 C

ATOM 5046 N Lεu ε 312 82.609 -11.753 25.041 1.00 41.79 N

ATOM 5047 CA Lεu ε 312 82.418 -13.188 24.869 1.00 40.92 C

ATOM 5048 C LEU E 312 82.405 -13.596 23.405 00 40.03 C

ATOM 5049 o LEU E 312 82.932 -14.643 23.040 00 40.10 O

ATOM 5050 CB LEU E 312 81.102 -13.625 25.519 00 42.05 C

ATOM 5051 CG LEU E 312 80.890 -13.141 26.956 00 43.75 C

ATOM 5052 CDl LEU ε 312 79.784 -13.962 27.606 00 42.68 C

ATOM 5053 CD2 LEU ε 312 82.187 -13.289 27.748 00 44.25 C

ATOM 5054 N LYS E 313 81.771 -12.785 22.569 00 38.60 N

ATOM 5055 CA LYS ε 313 81.715 -13.069 21.146 00 37.54 C

ATOM 5056 C LYS E 313 81.341 -11.805 20.395 00 36.63 C TOM 5057 o LYS E 313 80.612 -10.952 20.910 00 36.09 O

ATOM 5058 CB LYS E 313 80.741 -14.216 20.832 00 38.37 C

ATOM 5059 CG LYS E 313 79.283 -13.881 20.927 00 40.25 C

ATOM 5060 CD LYS E 313 78.434 -15.110 20.642 00 41.30 c

ATOM 5061 CE LYS E 313 78.667 -15.657 19.245 00 42.13 c

ATOM 5062 NZ LYS E 313 77.712 -16.764 18.931 00 43.04 N

ATOM 5063 N ALA E 314 81.871 -11.679 19.181 1.00 34.76 N

ATOM 5064 CA ALA E 314 81.633 -10.501 18.362 1.00 33.57 C

ATOM 5065 C ALA ε 314 81.531 -10.845 16.883 1.00 33.42 C

ATOM 5066 o ALA ε 314 82.287 -11.684 16.371 1.00 33.25 O

ATOM 5067 CB ALA E 314 82.744 -9.494 18.588 1.00 33.65 C

ATOM 5068 N ALA E 315 80.595 -10.185 16.201 00 32.14 N

ATOM 5069 CA ALA E 315 80.353 -10.398 14.780 00 31.01 C

ATOM 5070 C ALA E 315 81.549 -10.035 13.903 00 30.72 C

ATOM 5071 o ALA E 315 82.361 -9.177 14.257 00 30.48 O

ATOM 5072 CB ALA E 315 79.121 -9.607 14.335 00 30.66 C

ATOM 5073 N GLY E 316 81.631 -10.694 12.751 1.00 30.24 N

ATOM 5074 CA GLY E 316 82.708 -10.456 11.816 00 31.94 C

ATOM 5075 C GLY E 316 82.770 -11.540 10.755 00 33.59 C

ATOM 5076 o GLY E 316 81.899 -12.405 10.683 00 32.55 O

ATOM 5077 N VAL E 317 83.802 -11.479 9.925 00 35.48 N

ATOM 5078 CA VAL E 317 84.013 -12.449 8.860 00 38.38 C

ATOM 5079 C VAL E 317 84.061 -13.890 9.384 00 39.34 C Table 3

ATOM 5080 o VAL E 317 83.570 -14.810 8.732 00 39.08 O

ATOM 5081 CB VAL E 317 85.339 -12.140 8.121 00 39.18 C

ATOM 5082 CGI VAL E 317 85.814 -13.363 7.350 00 41.23 C

ATOM 5083 CG2 VAL E 317 85.133 -10.970 7.157 00 39.65 C

ATOM 5084 N ASN E 318 84.649 -14.073 10.563 00 41.02 N

ATOM 5085 CA ASN E 318 84.772 -15.397 11.165 00 42.81 C

ATOM 5086 C ASN E 318 83.640 -15.765 12.112 00 43.44 C

ATOM 5087 o ASN E 318 83.595 -16.879 12.635 00 43.81 O

ATOM 5088 CB ASN ε 318 86.113 -15.511 11.885 00 43.79 C

ATOM 5089 CG ASN ε 318 87.251 -15.783 10.928 00 44.65 C

ATOM 5090 ODl ASN E 318 88.377 -15.342 11.140 00 46.43 O

ATOM 5091 ND2 ASN E 318 86.961 -16.526 9.863 00 45.45 N

ATOM 5092 N THR E 319 82.728 -14.825 12.336 00 43.23 N

ATOM 5093 CA THR E 319 81.585 -15.058 13.207 00 42.64 C

ATOM 5094 C THR E 319 80.401 -14.304 12.607 00 42.30 C

ATOM 5095 o THR E 319 80.025 -13.224 13.070 00 41.73 O

ATOM 5096 CB THR E 319 81.845 -14.542 14.629 00 42.95 C

ATOM 5097 OG1 THR E 319 83.161 -14.923 15.053 00 43.57 O

ATOM 5098 CG2 THR E 319 80.829 -15.132 15.583 00 42.54 C

ATOM 5099 N THR E 320 79.841 -14.898 11.561 1.00 41.32 N

ATOM 5100 CA THR E 320 78.713 -14.381 10.791 1.00 41.14 C

ATOM 5101 C THR E 320 77.460 -13.982 11.580 1.00 40.79 C

ATOM 5102 o THR E 320 77.228 -14.481 12.679 1.00 40.11 O

ATOM 5103 CB THR E 320 78.327 -15.445 9.717 1.00 40.88 C

ATOM 5104 OG1 THR E 320 79.269 -15.385 8.642 1.00 41.69 O

ATOM 5105 CG2 THR E 320 76.926 -15.235 9.186 1.00 41.14 C

ATOM 5106 N ASP E 321 76.652 -13.091 10.995 1.00 40.17 N

ATOM 5107 CA ASP E 321 75.402 -12.634 11.608 1.00 40.26 C

ATOM 5108 C ASP E 321 74.370 -13.760 11.740 1.00 40.48 C

ATOM 5109 o ASP E 321 73.453 -13.671 12.551 1.00 40.99 O

ATOM 5110 CB ASP E 321 74.761 -11.492 10.785 1.00 40.57 C

ATOM 5111 CG ASP E 321 75.508 -10.164 10.911 1.00 40.77 C

ATOM 5112 ODl ASP E 321 76.166 -9.942 11.943 1.00 41.36 O

ATOM 5113 OD2 ASP E 321 75.421 -9.334 9.980 1.00 40.77 O

ATOM 5114 N LYS E 322 74.513 -14.812 10.941 1.00 40.71 N

ATOM 5115 CA LYS ε 322 73.561 -15.922 10.970 1.00 40.47 C

ATOM 5116 C LYS ε 322 73.340 -16.497 12.366 1.00 40.34 c

ATOM 5117 o LYS ε 322 72.213 -16.817 12.739 1.00 40.39 0

ATOM 5118 CB LYS E 322 74.014 -17.038 10.024 1.00 40.54 c

ATOM 5119 N GLU E 323 74.410 -16.605 13.146 1.00 39.99 N

ATOM 5120 CA GLU ε 323 74.304 -17.172 14.486 1.00 40.42 C

ATOM 5121 C GLU E 323 74.793 -16.255 15.616 1.00 40.12 C

ATOM 5122 o GLU E 323 74.975 -16.705 16.752 00 40.19 O

ATOM 5123 CB GLU E 323 75.079 -18.497 14.539 00 41.39 C

ATOM 5124 N ILε ε 324 74.980 -14.974 15.315 00 39.32 N

ATOM 5125 CA ILε E 324 75.472 -14.016 16.304 00 38.63 C

ATOM 5126 C ILε E 324 74.426 -13.586 17.349 00 37.71 C

ATOM 5127 o ILε ε 324 74.780 -13.190 18.455 1.00 36.93 O

ATOM 5128 CB ILε ε 324 76.038 -12.750 15.577 1.00 39.58 C

ATOM 5129 CGI ILε E 324 77.275 -12.216 16.305 1.00 40.68 C

ATOM 5130 CG2 ILE E 324 74.959 -11.683 15.445 1.00 38.88 C

ATOM 5131 CDl ILE E 324 77.023 -11.669 17.672 1.00 42.53 C

ATOM 5132 N GLU E 325 73.144 -13.681 17.010 1.00 37.22 N

ATOM 5133 CA GLU E 325 72.085 -13.264 17.932 1.00 38.65 C

ATOM 5134 C GLU ε 325 71.729 -14.213 19.085 1.00 39.26 C

ATOM 5135 o GLU E 325 70.838 -13.921 19.883 1.00 38.60 O

ATOM 5136 CB GLU E 325 70.816 -12.907 17.138 1.00 38.87 C

ATOM 5137 CG GLU E 325 70.909 -11.561 16.393 1.00 40.03 C

ATOM 5138 CD GLU ε 325 69.746 -11.319 15.432 1.00 41.78 c

ATOM 5139 OEl GLU ε 325 69.663 -12.037 14.413 1.00 42.23 o

ATOM 5140 oε2 GLU E 325 68.913 -10.415 15.693 1.00 42.02 o

ATOM 5141 N VAL E 326 72.414 -15.347 19.182 1.00 40.15 N

ATOM 5142 CA VAL ε 326 72.149 -16.281 20.270 1.00 41.03 C

ATOM 5143 C VAL ε 326 73.467 -16.648 20.937 1.00 41.51 C

ATOM 5144 o VAL ε 326 74.438 -16.974 20.264 1.00 41.62 O

ATOM 5145 CB VAL ε 326 71.456 -17.559 19.763 1.00 41.93 c ^^τ", "H ι^r 'Pi i'r "- ιi'r'r'^ι^,ιnιnιnιθι ι ιnιoιnιnιnιnιn nιnι ιnιoιθιnιnιnιnιnιnιnιoι^ oooσoooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

N « "l' ⁽Il m

O f

CM

r- r- ro

Nn^(,1ι^,)ι^,)nvfl^| "l^l ιπ Φ M PO CO

H CM H CM H CM H CM H CM H

O CJ⁾ rt C^Q CD O ^Q rt CQ O ^{Q Q} C-I W ti r-I rt C^Q CD O ^Q rt CQ rt CQ rt CQ rt CQ rt CQ rt CQ rt CQ CJ) ouzuυooooc^jzoooυoυcjc uυozoooooυozoooozoυoυzυuouzυooυzuυouzυuocjzϋoooo

Table 3

ATOM 5212 ODl ASP E 336 80.862 -18.865 33.010 1.00 50.96 0

ATOM 5213 OD2 ASP ε 336 79.817 -20.728 33.549 1.00 51.31 0

ATOM 5214 N ALA ε 337 77.808 -16.671 36.704 1.00 49.76 N

ATOM 5215 CA ALA ε 337 76.731 -15.803 37.167 1.00 49.26 C

ATOM 5216 C ALA E 337 77.085 -14.351 36.894 1.00 49.07 C

ATOM 5217 o ALA E 337 78.259 -13.976 36.914 1.00 49.31 o

ATOM 5218 CB ALA E 337 76.496 -16.005 38.658 1.00 49.40 c

ATOM 5219 N GLY E 338 76.072 -13.529 36.636 1.00 48.46 N

ATOM 5220 CA GLY E 338 76.341 -12.127 36.366 1.00 47.35 c

ATOM 5221 C GLY E 338 75.481 -11.508 35.280 1.00 46.17 c

ATOM 5222 o GLY E 338 74.546 -12.134 34.772 1.00 45.24 o

ATOM 5223 N GLU E 339 75.818 -10.270 34.924 1.00 44.77 N

ATOM 5224 CA GLU E 339 75.089 -9.513 33.916 1.00 44.35 C

ATOM 5225 C GLU E 339 75.652 -9.701 32.496 1.00 42.94 C

ATOM 5226 o GLU E 339 76.840 -9.459 32.249 1.00 41.99 o

ATOM 5227 CB GLU E 339 75.121 -8.028 34.296 1.00 44.65 C

ATOM 5228 CG GLU E 339 74.100 -7.163 33.591 1.00 46.70 C

ATOM 5229 CD GLU E 339 74.220 -5.708 33.992 1.00 47.49 C

ATOM 5230 oεi GLU E 339 74.666 -5.448 35.127 1.00 48.94 o

ATOM 5231 oε2 GLU E 339 73.862 -4.823 33.186 1.00 48.65 o

ATOM 5232 N TYR E 340 74.790 -10.145 31.579 1.00 41.66 N

ATOM 5233 CA TYR E 340 75.160 -10.339 30.172 1.00 40.54 C

ATOM 5234 C TYR E 340 74.485 -9.267 29.314 1.00 39.53 C

ATOM 5235 o TYR ε 340 73.307 -8.955 29.504 1.00 39.67 o

ATOM 5236 CB TYR ε 340 74.754 -11.736 29.687 1.00 40.75 C

ATOM 5237 CG TYR E 340 75.595 -12.833 30.302 1.00 43.00 c

ATOM 5238 CDl TYR ε 340 75.423 -13.199 31.637 1.00 43.39 c

ATOM ^■ 5239 CD2 TYR ε 340 76.624 -13.446 29.576 1.00 42.97 c

ATOM 5240 CEl TYR E 340 76.260 -14.144 32.246 1.00 43.85 c

ATOM 5241 CE2 TYR E 340 77.465 -14.391 30.172 1.00 44.16 c

ATOM 5242 CZ TYR E 340 77.279 -14.732 31.513 1.00 44.42 c

ATOM 5243 OH TYR E 340 78.124 -15.631 32.126 1.00 43.97 o

ATOM 5244 N THR E 341 75.225 -8.718 28.356 1.00 37.76 N

ATOM 5245 CA THR E 341 74.692 -7.661 27.514 1.00 36.11 C

ATOM 5246 C THR ε 341 74.844 -7.882 26.013 1.00 35.29 C

ATOM 5247 o THR E 341 75.913 -8.245 25.535 1.00 35.15 o

ATOM 5248 CB THR E 341 75.384 -6.311 27.837 1.00 35.87 c

ATOM 5249 OG1 THR E 341 75.114 -5.936 29.192 1.00 36.17 o

ATOM 5250 CG2 THR E 341 74.901 -5.219 26.902 1.00 35.45 c

ATOM 5251 N CYS E 342 73.765 -7.667 25.273 1.00 34.30 N

ATOM 5252 CA CYS E 342 73.838 -7.755 23.820 1.00 33.50 C

ATOM 5253 C CYS E 342 73.962 -6.303 23.397 1.00 32.08 C

ATOM 5254 o CYS E 342 73.088 -5.491 23.685 1.00 31.94 o

ATOM 5255 CB CYS E 342 72.577 -8.347 23.201 1.00 33.31 C

ATOM 5256 SG CYS ε 342 72.527 -8.113 21.399 1.00 35.61 s

ATOM 5257 N LEU E 343 75.056 -5.977 22.724 1.00 31.56 N

ATOM 5258 CA LEU E 343 75.292 -4.610 22.278 1.00 30.17 C

ATOM 5259 C LEU E 343 75.366 -4.522 20.758 1.00 29.58 C

ATOM 5260 o LEU E 343 76.132 -5.245 20.121 1.00 29.15 o

ATOM 5261 CB LEU Ξ 343 76.581 -4.080 22.913 1.00 29.36 C

ATOM 5262 CG LEU ε 343 76.957 -2.619 22.680 1.00 28.90 C

ATOM 5263 CDl LEU E 343 77.509 -2.017 23.964 1.00 29.70 C

ATOM 5264 CD2 LEU ε 343 77.972 -2.529 21.551 1.00 29.96 C

ATOM 5265 N ALA E 344 74.552 -3.633 20.189 1.00 28.85 N

ATOM 5266 CA ALA ε 344 74.505 -3.430 18.751 1.00 28.63 C

ATOM 5267 C ALA E 344 74.810 -1.983 18.371 1.00 28.87 C

ATOM 5268 o ALA ε 344 74.230 -1.039 18.915 1.00 29.04 o

ATOM 5269 CB ALA ε 344 73.138 -3.837 18.206 1.00 28.59 c

ATOM 5270 N GLY E 345 75.725 -1.806 17.425 1.00 28.49 N

ATOM 5271 CA GLY E 345 76.060 -0.465 16.998 1.00 27.62 C

ATOM 5272 C GLY ε 345 76.246 -0.322 15.499 1.00 27.14 C

ATOM 5273 o GLY ε 345 76.625 -1.281 14.821 1.00 25.46 o

ATOM 5274 N ASN E 346 75.922 0.869 14.986 1.00 26.69 N

ATOM 5275 CA ASN E 346 76.132 1.217 13.579 1.00 27.69 C

ATOM 5276 C ASN E 346 76.744 2.621 13.563 1.00 28.33 C

ATOM 5277 o ASN E 346 77.004 3.190 14.623 1.00 27.30 o CO ouozzuuouozoυoouuυzuuozc υoocjuuzuuooozoc ooooυυoozuc ooozcjuzzcjuoc ozuυ

(. ι. ιJι H VO ιn oιo H oooσoooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooσooooooooooooooooooooooooooooooooooooooooooooo

HHHHHHHHHHHHHHH, HHHHHHHHHHH,

Hτ φ H n co

^O ^D ^ ιn rι ^l⁾<Λ ^ι o d d O ιι⁾ ιn ιn d ι^ O d O N ⁽I^ ^ r^• o ^o o B ^ ι^,l ιIl o v oo ( lI) ι^{,) (}I a⁾ a) o al H ln n (n v ι o o o o ιn d Φ "P ln < ∞ CO O O CΛ o ^{O l ιΛ ιIι O ln Φ ιη » ln "l' ι^,^ Φ ι^,l ι o ^ r^■ N lB O ln N a⁾ ιn d d H ⁽^ ιn Φ ι Λ lJl d ι^ι ι^,) 0 (M m o ι o o 1^| ιn -l ^ 1^ d N a3 ^ 0 "» ι⁾ι oo "l^, 1l⁾ ιιl ^ ιo m < d "^ ω ιo ω ιJl (D ιo o o ( O ιn d O "f (M ^ N l» d l ln Φ r^ ^ι ^^ p ιJl σ! σl Φ "f Mn oo ιn n o d ιJ^ oo r- co σ co ι^, co ι^, H θo t-- vD r- ιr) CD θ H θoθ H M θ iΛ o r- r- r- r~ co ιo _> CD CD CD c~ r~ c-- CD r- r-- r- co r--

ω ω ω ω ω ω ω ω ω ω ω ω ω ω w ω w w ω ω ω ω i-i cd ω ω z z z z oi ρ- cC o- p- p- w w w w ω ω w ι_ι >H >H H >H w w w ω ω ω ω ω Λ cιi Λ - Λ ro o g g ω ω ω ω ω c-i iJ Hi H^ H^ H^ H^ Hi H^ Hi J j i-i ^ Hj HS Hi H^ HP HA Hi ω ω rt rt rt rt W CO C C C CO H H H H H H H H CD O O U H H H H H H H H M OT CO W C C C C I-j Cll l-l l-j C I-i fti l-i C-i E -C

H CM H CM H H CM H H CM H CM H CM H CM ^Q c^{j) Q} O _ rt _Λ ⁽0 θ < o o a rt CQ CD CD Q < m CQ CD Q Q W W N rt ca CD a a ω ω ft Q CD < o o o z z o u o u o z υ c^j o o u o c z c c^j o z u o o c^j υ o u z o u o o o z o c^j o u u c^j υ υ o u z o u o c cj z c^j u z z υ υ o o o z u u

Tab 3

ATOM 5344 0 ALA E 355 72.072 -10.179 32.359 1.00 42.09 o

ATOM 5345 CB ALA E 355 69.428 -10.886 30.438 1.00 40.51 c

ATOM 5346 N TRP E 356 70.273 -11.023 33.425 1.00 42.87 N

ATOM 5347 CA TRP E 356 71.055 -11.597 34.508 1.00 44.67 c

ATOM 5348 C TRP E 356 71.021 -13.119 34.519 1.00 44.89 C

ATOM 5349 o TRP ε 356 69.995 -13.734 34.237 1.00 44.45 o

ATOM 5350 CB TRP ε 356 70.542 -11.068 35.856 1.00 46.66 C

ATOM 5351 CG TRP ε 356 71.644 -10.589 36.745 1.00 48.84 C

ATOM 5352 CDl TRP E 356 72.536 -11.360 37.436 1.00 49.57 C

ATOM 5353 CD2 TRP E 356 72.051 -9.229 36.940 1.00 49.66 c

ATOM 5354 NEl TRP E 356 73.483 -10.563 38.041 1.00 50.48 N

ATOM 5355 CE2 TRP ε 356 73.209 -9.251 37.752 1.00 50.21 C

ATOM 5356 CE3 TRP E 356 71.551 -7.992 36.501 1.00 50.27 C

ATOM 5357 CZ2 TRP E 356 73.883 -8.080 38.137 1.00 50.52 C

ATOM 5358 CZ3 TRP ε 356 72.221 -6.824 36.883 1.00 50.86 C

ATOM 5359 CH2 TRP E 356 73.375 -6.881 37.693 1.00 50.85 C

ATOM 5360 N LEU ε 357 72.163 -13.719 34.835 1.00 45.24 N

ATOM 5361 CA LEU E 357 72.275 -15.165 34.929 1.00 46.28 C

ATOM 5362 C LEU E 357 72.416 -15.529 36.404 1.00 47.03 C

ATOM 5363 o LEU ε 357 73.362 -15.085 37.064 1.00 47.09 o

ATOM 5364 CB LEU ε 357 73.516 -15.662 34.180 1.00 46.24 C

ATOM 5365 CG Lεu £ 357 73.855 -17.138 34.418 1.00 46.22 C

ATOM 5366 CDl Lεu ε 357 72.722 -18.004 33.879 1.00 45.74 C

ATOM 5367 CD2 Lεu E 357 75.184 -17.493 33.742 1.00 45.83 C

ATOM 5368 N THR E 358 71.481 -16.323 36.920 1.00 47.80 N

ATOM 5369 CA THR ε 358 71.525 -16.754 38.317 1.00 49.40 C

ATOM 5370 C THR ε 358 71.935 -18.221 38.360 1.00 49.88 c

ATOM 5371 o THR ε 358 71.300 -19.067 37.725 1.00 49.63 o

ATOM 5372 CB THR ε 358 70.144 -16.626 39.010 1.00 50.27 c

ATOM 5373 OG1 THR ε 358 69.709 -15.263 38.980 1.00 51.35 o

ATOM 5374 CG2 THR ε 358 70.231 -17.083 40.466 1.00 51.00 c

ATOM 5375 N VAL ε 359 72.995 -18.515 39.108 1.00 50.99 N

ATOM 5376 CA VAL E 359 73.496 -19.878 39.239 1.00 52.26 C

ATOM 5377 C VAL E 359 73.291 -20.372 40.671 1.00 53.50 C

ATOM 5378 o VAL E 359 73.879 -19.828 41.617 1.00 53.34 o

ATOM 5379 CB VAL E 359 75.001 -19.954 38.883 1.00 52.03 C

ATOM 5380 N LEU E 360 72.454 -21.405 40.806 1.00 54.72 N

ATOM 5381 CA LEU E 360 72.118 -22.014 42.095 1.00 55.76 C

ATOM 5382 C LEU E 360 73.006 -23.217 42.403 1.00 56.27 C

ATOM 5383 o LEU E 360 73.018 -24.147 41.566 1.00 56.89 o

ATOM 5384 CB LEU E 360 70.650 -22.456 42.095 1.00 55.94 C

TER 5385 LEU E 360

ATOM 5386 N ASN F 150 27.465 32.706 43.234 1.00 47.18 N

ATOM 5387 CA ASN F 150 26.839 33.873 43.929 1.00 46.68 C

ATOM 5388 C ASN F 150 25.823 34.566 43.015 1.00 45.81 C

ATOM 5389 o ASN F 150 25.993 34.593 41.797 1.00 46.29 o

ATOM 5390 CB ASN F 150 27.924 34.872 44.357 1.00 46.26 C

ATOM 5391 N LYS F 151 24.769 35.116 43.612 1.00 45.07 N

ATOM 5392 CA LYS F 151 23.717 35.815 42.874 1.00 43.78 C

ATOM 5393 C LYS F 151 24.148 37.251 42.548 1.00 43.34 C

ATOM 5394 o LYS F 151 24.545 38.007 43.432 1.00 42.87 o

ATOM 5395 CB LYS F 151 22.421 35.835 43.695 1.00 43.03 C

ATOM 5396 N ARG F 152 24.073 37.627 41.274 1.00 42.12 N

ATOM 5397 CA ARG F 152 24.472 38.973 40.878 1.00 40.51 C

ATOM 5398 C ARG F 152 23.794 39.481 39.608 1.00 39.03 C

ATOM 5399 o ARG F 152 23.353 38.706 38.754 1.00 38.69 o

ATOM 5400 CB ARG F 152 25.988 39.035 40.701 1.00 40.57 C

ATOM 5401 CG ARG F 152 26.528 38.034 39.696 1.00 41.38 C

ATOM 5402 CD ARG F 152 28.045 38.053 39.645 1.00 40.83 C

ATOM 5403 NE ARG F 152 28.574 39.325 39.162 1.00 40.31 N

ATOM 5404 CZ ARG F 152 29.816 39.487 38.712 1.00 40.01 C

ATOM 5405 NHl ARG F 152 30.657 38.461 38.693 1.00 39.33 N

ATOM 5406 NH2 ARG F 152 30.211 40.665 38.250 1.00 40.37 N

ATOM 5407 N ALA F 153 23.725 40.802 39.503 1.00 37.59 N

ATOM 5408 CA ALA F 153 23.127 41.470 38.361 1.00 36.00 C

ATOM 5409 C ALA F 153 23.905 41.142 37.085 1.00 34.93 C Table 3

ATOM 5410 o ALA F 153 25.018 40.633 37.139 1.00 34.72 0 TOM 5411 CB ALA F 153 23.105 42.987 38.604 1.00 35.68 c

ATOM 5412 N PRO F 154 23.322 41.436 35.916 1.00 34.45 N

ATOM 5413 CA PRO F 154 23.987 41.158 34.640 1.00 33.61 C TOM 5414 C PRO F 154 25.229 42.013 34.427 1.00 33.12 C

ATOM 5415 o PRO F 154 25.312 43.137 34.922 1.00 32.79 o

ATOM 5416 CB PRO F 154 22.894 41.447 33.624 1.00 33.95 C

ATOM 5417 CG PRO F 154 22.131 42.546 34.284 1.00 34.26 C

ATOM 5418 CD PRO F 154 22.018 42.086 35.698 1.00 33.81 C

ATOM 5419 N TYR F 155 26.194 41.465 33.697 1.00 33.26 N

ATOM 5420 CA TYR F 155 27.432 42.171 33.406 1.00 34.23 C

ATOM 5421 C TYR F 155 28.054 41.642 32.109 1.00 34.53 C

ATOM 5422 o TYR F 155 27.912 40.466 31.786 1.00 34.70 o

ATOM 5423 CB TYR F 155 28.416 42.010 34.571 1.00 35.21 C

ATOM 5424 CG TYR F 155 28.879 40.587 34.807 1.00 36.38 c

ATOM 5425 CDl TYR F 155 28.033 39.637 35.387 1.00 37.46 c

ATOM 5426 CD2 TYR F 155 30.153 40.183 34.422 1.00 36.66 c

ATOM 5427 CEl TYR F 155 28.450 38.317 35.573 1.00 37.51 c

ATOM 5428 CE2 TYR F 155 30.579 38.871 34.602 1.00 37.68 c

ATOM 5429 CZ TYR F 155 29.725 37.944 35.172 1.00 38.34 c

ATOM 5430 OH TYR F 155 30.150 36.637 35.313 1.00 39.80 o

ATOM 5431 N TRP F 156 28.731 42.519 31.373 1.00 34.56 N

ATOM 5432 CA TRP F 156 29.385 42.141 30.123 1.00 36.40 c

ATOM 5433 C TRP F 156 30.610 41.270 30.415 1.00 38.32 c

ATOM 5434 o TRP F 156 31.454 41.648 31.229 1.00 39.35 o

ATOM 5435 CB TRP F 156 29.828 43.402 29.369 1.00 34.91 c

ATOM 5436 CG TRP F 156 28.743 44.408 29.136 1.00 33.24 c

ATOM 5437 CDl TRP F 156 28.809 45.743 29.385 1.00 32.54 c

ATOM 5438 CD2 TRP F 156 27.434 44.162 28.598 1.00 32.50 c

ATOM 5439 NEl TRP F 156 27.630 46.352 29.041 1.00 31.97 N

ATOM 5440 cε2 TRP F 156 26.764 45.409 28.553 1.00 32.15 C

ATOM 5441 cε3 TRP F 156 26.761 43.011 28.147 1.00 31.76 c

ATOM 5442 CZ2 TRP F 156 25.447 45.544 28.079 1.00 31.23 c

ATOM 5443 CZ3 TRP F 156 25.445 43.143 27.670 1.00 31.94 c

ATOM 5444 CH2 TRP F 156 24.806 44.404 27.642 1.00 31.30 c

ATOM 5445 N THR F 157 30.710 40.121 29.748 1.00 40.38 N

ATOM 5446 CA THR F 157 31.826 39.198 29.952 1.00 42.48 C

ATOM 5447 C THR F 157 32.970 39.388 28.967 1.00 43.74 C

ATOM 5448 o THR F 157 33.988 38.708 29.059 1.00 44.97 o

ATOM 5449 CB THR F 157 31.353 37.738 29.878 1.00 43.02 C

ATOM 5450 OG1 THR F 157 30.716 37.495 28.613 1.00 43.13 o

ATOM 5451 CG2 THR F 157 30.371 37.453 31.004 1.00 43.29 c

ATOM 5452 N ASN F 158 32.808 40.306 28.022 1.00 45.46 N

ATOM 5453 CA ASN F 158 33.862 40.578 27.046 1.00 46.50 C

ATOM 5454 C ASN F 158 33.649 41.918 26.355 1.00 46.39 C

ATOM 5455 o ASN F 158 33.122 41.974 25.246 1.00 46.75 o

ATOM 5456 CB ASN F 158 33.936 39.472 25.988 1.00 48.38 C

ATOM 5457 CG ASN F 158 35.162 39.613 25.080 1.00 50.17 C

ATOM 5458 ODl ASN F 158 35.297 40.586 24.326 1.00 50.24 o

ATOM 5459 ND2 ASN F 158 36.063 38.640 25.158 1.00 50.64 N

ATOM 5460 N THR F 159 34.075 42.992 27.015 1.00 46.28 N

ATOM 5461 CA THR F 159 33.927 44.340 26.480 1.00 46.80 C

ATOM 5462 C THR F 159 34.772 44.588 25.240 1.00 47.39 C

ATOM 5463 0 THR F 159 34.495 45.516 24.479 1.00 47.37 o

ATOM 5464 CB THR F 159 34.302 45.422 27.530 1.00 47.53 C

ATOM 5465 OG1 THR F 159 35.591 45.130 28.084 1.00 48.04 o

ATOM 5466 CG2 THR F 159 33.269 45.471 28.657 1.00 48.15 C

ATOM 5467 N GLU F 160 35.807 43.770 25.048 1.00 47.49 N

ATOM 5468 CA GLU F 160 36.695 43.913 23.900 1.00 47.50 C

ATOM 5469 C GLU F 160 35.894 43.832 22.602 1.00 47.37 C

ATOM 5470 o GLU F 160 36.019 44.683 21.727 1.00 47.28 o

ATOM 5471 CB GLU F 160 37.764 42.812 23.922 1.00 47.86 C

ATOM 5472 N LYS F 161 35.058 42.805 22.505 1.00 46.88 N

ATOM 5473 CA LYS F 161 34.225 42.574 21.335 1.00 46.63 C

ATOM 5474 C LYS F 161 33.062 43.566 21.194 1.00 45.96 C

ATOM 5475 o LYS F 161 32.268 43.452 20.261 1.00 45.92 o Table 3

ATOM 5476 CB LYS F 161 33.663 41.144 21.386 1.00 47.58 c

ATOM 5477 N MET F 162 32.962 44.528 22.111 1.00 45.07 N

ATOM 5478 CA MET F 162 31.876 45.514 22.088 1.00 44.13 c

ATOM 5479 C MET F 162 32.350 46.941 21.834 1.00 43.91 C

ATOM 5480 o MET F 162 31.532 47.852 21.671 1.00 43.60 o

ATOM 5481 CB MET F 162 31.110 45.491 23.417 1.00 43.45 C

ATOM 5482 CG MET F 162 30.339 44.215 23.708 1.00 42.75 C

ATOM 5483 SD MET F 162 29.681 44.224 25.407 1.00 44.78 S

ATOM 5484 cε MET F 162 28.618 45.682 25.364 1.00 42.60 C

ATOM 5485 N GLU F 163 33.663 47.139 21.796 1.00 43.66 N

ATOM 5486 CA GLU F 163 34.228 48.474 21.595 1.00 43.05 C

ATOM 5487 C GLU F 163 33.900 49.117 20.245 1.00 42.02 C

ATOM 5488 o GLU F 163 33.747 50.336 20.150 1.00 42.39 o

ATOM 5489 CB GLU F 163 35.748 48.432 21.790 1.00 43.51 C

ATOM 5490 N LYS F 164 33.801 48.302 19.201 1.00 40.60 N

ATOM 5491 CA LYS F 164 33.482 48.806 17.866 1.00 38.52 C

ATOM 5492 C LYS F 164 31.982 49.137 17.821 1.00 37.22 C

ATOM 5493 o LYS F 164 31.152 48.253 17.609 1.00 36.84 o

ATOM 5494 CB LYS F 164 33.835 47.742 16.820 1.00 37.86 C

ATOM 5495 CG LYS F 164 33.861 48.266 15.410 1.00 37.96 C

ATOM 5496 CD LYS F 164 34.340 47.228 14.408 1.00 37.78 C

ATOM 5497 cε LYS F 164 33.188 46.490 13.757 1.00 38.14 C

ATOM 5498 NZ LYS F 164 33.621 45.853 12.478 1.00 39.11 N

ATOM 5499 N ARG F 165 31.644 50.407 18.025 1.00 35.96 N

ATOM 5500 CA ARG F 165 30.247 50.843 18.044 1.00 35.34 C

ATOM 5501 C ARG F 165 29.614 51.005 16.672 1.00 33.90 C

ATOM 5502 o ARG F 165 28.468 50.609 16.466 1.00 32.97 o

ATOM 5503 CB ARG F 165 30.110 52.151 18.833 1.00 36.33 c

ATOM 5504 CG ARG F 165 30.254 51.954 20.333 1.00 39.65 c

ATOM 5505 CD ARG F 165 30.371 53.273 21.066 1.00 42.36 c

ATOM 5506 Nε ARG F 165 30.713 53.076 22.472 1.00 45.53 N

ATOM 5507 CZ ARG F 165 29.837 52.783 23.429 1.00 47.06 c

ATOM 5508 NHl ARG F 165 28.540 52.656 23.148 1.00 47.85 N

ATOM 5509 NH2 ARG F 165 30.262 52.607 24.671 1.00 47.69 N

ATOM 5510 N LEU F 166 30.364 51.593 15.746 1.00 33.06 N

ATOM 5511 CA LEU F 166 29.905 51.808 14.379 1.00 32.49 C

ATOM 5512 C LEU F 166 30.309 50.638 13.497 1.00 32.80 C

ATOM 5513 o LEU F 166 31.498 50.360 13.350 1.00 32.69 o

ATOM 5514 CB LEU F 166 30.528 53.083 13.801 1.00 30.33 C

ATOM 5515 CG LEU F 166 30.342 53.309 12.288 1.00 31.08 C

ATOM 5516 CDl LEU F 166 28.859 53.376 11.924 1.00 28.89 C

ATOM 5517 CD2 LEU F 166 31.033 54.592 11.879 1.00 28.85 C

ATOM 5518 N HIS F 167 29.322 49.957 12.918 1.00 32.67 N

ATOM 5519 CA HIS F 167 29.565 48.837 12.015 1.00 32.58 C

ATOM 5520 C HIS F 167 29.153 49.268 10.614 1.00 33.20 - C

ATOM 5521 o HIS F 167 27.959 49.316 10.302 1.00 33.21 o

ATOM 5522 CB HIS F 167 28.737 47.609 12.413 1.00 33.93 c

ATOM 5523 CG HIS F 167 29.317 46.814 13.541 1.00 35.95 c

ATOM 5524 ND1 HIS F 167 29.561 47.350 14.788 1.00 37.05 N

ATOM 5525 CD2 HIS F 167 29.699 45.516 13.609 1.00 35.66 C

ATOM 5526 cεi HIS F 167 30.070 46.418 15.574 1.00 36.41 C

ATOM 5527 Nε2 HIS F 167 30.164 45.296 14.882 1.00 36.24 N

ATOM 5528 N ALA F 168 30.135 49.601 9.782 1.00 32.49 N

ATOM 5529 CA ALA F 168 29.872 50.015 8.408 1.00 32.62 C

ATOM 5530 C ALA F 168 30.255 48.815 7.562 1.00 32.27 C

ATOM 5531 o ALA F 168 31.394 48.362 7.614 1.00 32.31 o

ATOM 5532 CB ALA F 168 30.739 51.224 8.040 1.00 33.46 C

ATOM 5533 N VAL F 169 29.310 48.299 6.786 1.00 31.84 N

ATOM 5534 CA VAL F 169 29.574 47.125 5.965 1.00 31.85 C

ATOM 5535 C VAL F 169 29.011 47.239 4.557 1.00 31.61 C

ATOM 5536 o VAL F 169 28.063 47.977 4.311 1.00 31.56 o

ATOM 5537 CB VAL F 169 28.959 45.859 6.596 1.00 32.55 C

ATOM 5538 CGI VAL F 169 29.416 45.725 8.046 1.00 33.61 C

ATOM 5539 CG2 VAL F 169 27.441 45.928 6.515 1.00 31.02 c

ATOM 5540 N PRO F 170 29.592 46.491 3.616 1.00 31.38 N

ATOM 5541 CA PRO F 170 29.123 46.525 2.234 1.00 31.61 C Table 3

ATOM 5542 C PRO F 170 27 .809 45, ,763 2. .103 1. ,00 32, .21 c

ATOM 5543 0 PRO F 170 27 .585 44, .761 2. ,789 1. .00 31. .90 o

ATOM 5544 CB PRO F 170 30 .267 45. .863 1, ,472 1. ,00 31. .99 c

ATOM 5545 CG PRO F 170 30 .758 44. .824 2. .463 1, .00 31. .40 c

ATOM 5546 CD PRO F 170 30, .722 45. .556 3. ,784 1. ,00 30. .53 c

ATOM 5547 N ALA F 171 26, .931 46. .251 1. ,234 1, ,00 33. .14 N

ATOM 5548 CA ALA F 171 25, .640 45, .606 1. .009 1. .00 33, ,63 C

ATOM 5549 C ALA F 171 25, .821 44. .140 0. .596 1. .00 33. .79 C

ATOM 5550 0 ALA F 171 26 .811 43. .779 -0. ,049 1, ,00 32. .97 O

ATOM 5551 CB ALA F 171 24, .863 46. ,362 -0, .063 1. .00 33. .56 c

ATOM 5552 N ALA F 172 24, .863 43. .303 1, .001 1. ,00 33, .61 N

ATOM 5553 CA ALA F 172 24, .849 41. .872 0, .699 1, ,00 33. .16 C

ATOM 5554 C ALA F 172 25, .643 41. ,011 1, ,684 1. ,00 33. .77 C

ATOM 5555 o ALA F 172 25, .654 39. ,778 1, ,579 1, ,00 33. .75 O

ATOM 5556 CB ALA F 172 25, .328 41. ,622 -0, ,744 1, ,00 33, .35 C

ATOM 5557 N ASN F 173 26. .310 41. ,640 2. ,642 1, ,00 33, ,18 N

ATOM 5558 CA ASN F 173 27. .061 40. ,866 3. .629 1, ,00 33, ,48 C

ATOM 5559 C ASN F 173 26. .191 40. ,528 4, .839 1, .00 32, .36 C

ATOM 5560 o ASN F 173 25. .077 41. ,033 4. ,980 1, ,00 31, ,26 O

ATOM 5561 CB ASN F 173 28. .314 41. ,636 4, ,062 1, ,00 34. ,43 C

ATOM 5562 CG ASN F 173 29, ,483 41. ,423 3. ,108 1, ,00 36, ,77 C

ATOM 5563 ODl ASN F 173 29. .307 41. ,276 1, ,890 1, .00 37, .96 O

ATOM 5564 ND2 ASN F 173 30. .683 41. .413 3. ,657 1, .00 38, .51 N

ATOM 5565 N THR F 174 26. ,698 39. .648 5. ,693 1. .00 31. .64 N

ATOM 5566 CA THR F 174 26, .000 39, ,268 6. .913 1, .00 30. ,65 C

ATOM 5567 C THR F 174 26, .589 40, ,107 8. .047 1, .00 30. .96 C

ATOM 5568 o THR F 174 27, ,799 40. ,333 8. ,083 1. ,00 31, .98 O

ATOM 5569 CB THR F 174 26. ,217 37. ,779 7. ,249 1, ,00 29. .86 C

ATOM 5570 OG1 THR F 174 25, .397 36, ,961 6. ,402 1. .00 30. .18 O

ATOM 5571 CG2 THR F 174 25, .869 37, ,507 8. ,692 1. .00 29. ,82 C

ATOM 5572 N VAL F 175 25, .741 40. ,573 8. ,961 1. ,00 30. ,45 N

ATOM 5573 CA VAL F 175 26, .200 41. ,363 10. ,100 1. ,00 30. ,13 C

ATOM 5574 C VAL F 175 25. .868 40. .632 11. .394 1. .00 30. .00 C

ATOM 5575 o VAL F 175 24. .807 40. .009 11, ,514 1. ,00 29. ,84 o

ATOM 5576 CB VAL F 175 25. .521 42. ,754 10. ,153 1. ,00 30. ,57 c

ATOM 5577 CGI VAL F 175 26. .040 43. .542 11, .348 1, ,00 31, .35 c

ATOM 5578 CG2 VAL F 175 25. .807 43. .510 8. .890 1, ,00 30, .75 c

ATOM 5579 N LYS F 176 26. ,775 40. .693 12. ,360 1. ,00 29, .06 N

ATOM 5580 CA LYS F 176 26. .538 40. ,047 13. .640 1, ,00 29, ,99 C

ATOM 5581 C LYS F 176 26. .914 40. .962 14. .805 1, .00 30, .49 C

ATOM 5582 o LYS F 176 28, ,048 41. .443 14. .894 1, ,00 30, .73 O

ATOM 5583 CB LYS F 176 27. ,328 38. ,734 13. .733 1. ,00 32, .08 C

ATOM 5584 CG LYS F 176 27. ,054 37, .893 15. .000 1, ,00 34, .61 c

ATOM 5585 CD LYS F 176 27. .852 36. ,559 15. .005 1, ,00 35. .52 c

ATOM 5586 CE LYS F 176 27. ,675 35. ,791 16. .324 1, ,00 38. .38 c

ATOM 5587 NZ LYS F 176 28. .376 34. ,451 16. ,397 1. ,00 37, .91 N

ATOM 5588 N PHE F 177 25. .953 41. .213 15. .688 1, .00 29, .86 N

ATOM 5589 CA PHE F 177 26, ,198 42. ,038 16, ,861 1, ,00 29, .32 C

ATOM 5590 C PHE F 177 26. ,219 41. ,125 18. .065 1. .00 29, .40 C

ATOM 5591 o PHE F 177 25. ,412 40. ,210 18. .156 1. .00 30, .08 O

ATOM 5592 CB PHE F 177 25. ,095 43. .080 17. .024 1, .00 28. .12 C

ATOM 5593 CG PHE F 177 25. ,075 44, .108 15. .931 1, .00 28. .38 C

ATOM 5594 CDl PHE F 177 26. ,193 44. .903 15. .689 1. ,00 27, ,55 C

ATOM 5595 CD2 PHE F 177 23. ,929 44. .306 15. .163 1, ,00 28. .25 C

ATOM 5596 CEl PHE F 177 26. ,170 45. .877 14. .709 1, .00 27, .35 C

ATOM 5597 CE2 PHE F 177 23. ,897 45. .285 14. ,176 1, .00 28. ,12 C

ATOM 5598 CZ PHE F 177 25. ,021 46. ,073 13. .949 1. ,00 28. .28 C

ATOM 5599 N ARG F 178 27. ,142 41, ,371 18, .988 1, .00 29. .44 N

ATOM 5600 CA ARG F 178 27. ,254 40, ,549 20. ,187 1, .00 29. .63 C

ATOM 5601 C ARG F 178 27. ,345 41. .365 21. .481 1, .00 29. .59 C

ATOM 5602 o ARG F 178 27. ,910 42, ,467 21. .513 1. .00 27, .47 O

ATOM 5603 CB ARG F 178 28. ,489 39, ,639 20. .097 1. .00 30, .99 C

ATOM 5604 CG ARG F 178 28. ,567 38, .762 18. .847 1. .00 36. .16 C

ATOM 5605 CD ARG F 178 29. 692 37, ,737 18. ,978 1, ,00 38. .76 C

ATOM 5606 NE ARG F 178 29. ,502 36, ,952 20. .194 1. .00 43. .37 N

ATOM 5607 CZ ARG F 178 30. 425 36. ,178 20. ,760 1, ,00 45. .05 C o

o β σι

"j iiCMc co c c c c c roro c f coc c c ro roc c co co ro c co n *ι ^,ι^,ι^, ιτι^,'j ι^,'rτ 'j ι^,ι^,tnmι^,ι ι*ι*ι ι ι^,ι^,ι*i' "a i' τιι c oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooσooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

ιA σι βι o v O Φ Hr n ιn o d ω ιι o r" n (4 Φ <M n « ι^,1 <π n cD O lA H βι n Φ O H ιf) eo ιN n oo o n rl IM l - o ι l H Φ Oι ιn « H l Φ C4 ln m <^ H "l' (J1 Φ » ln o3 ^ ιι^ ι <D "l^| o ιnω ^ ιη ι» n (M <M ^ <n ι<l ιn ( ιη n oo Φ o l ^ σl Φ d d ι » O H ιn "l' Φ d ι oJ 'ι^, o o "» ι ^ O ( -) o ιn ^ ^ π o lfl Φ ln σ oι f ^ σ cM v c*ι <M oo ιD n "r ιn (D ιfi a) ^ r O O o σ^ "l^, Φ Φ m (η ^ ^ a) r ιOO Λ aϊO H oo o (N ιn f ^Λ M ^ ^ ι σi (M ( Φ ^

Φ ιn o H O O M m ιJl ω _ Λ _ (D m ω ω ^ Φo^ ^ ^ ω Φ Φ ιn "^ fl "» ln Φ ^ H^ n v ιn ι^ ^ ιn π n « « l H ^l N ^ Φ _ (D σl ^ oo co (^l m _ 00

CO C 1* 1* 1^, 'T '* 1* lO CO C <O C rπ cO fO CO CO C CO C C CO C C C fO C CO C f"l C lO CO C^ ro _ d Hf Φ H

a)a) (_∞coω fa fa h ta u b ta t-i b h u fa fa fa fa fo fxi Cu l-i l-i ta xj h

O lD c co co co co co O O O O O O O rt rt rt Z Z Z Z Z O O O O O O O EH EH EH EH EH H EH EH O O O O O O O OJ l-J pci P- f-i PS PS EH H EH EH

PU Λ >^H >^H >^H >H H (ϊi C; θ- 0. 0- Ct; P- Hl Hl H3 w∞∞∞to&cicύXPi aiwwHaawamΛoifύa&KPi X xxxxωbaωω rt rt υo c^j c^j o c^j aι a4 θj i-ι C-ιθι P- rt rt rt O CD O CD CD CD ID CJ) rtrtrtrtrt&θ4 .PL<c_cij L<εε 22a2a---Mcι< ^χιQ -ι -ιEHEHEHEHEH H H_ εεε

H CM H CM

K EC rt _ P^Q O rt C^Q CD ^Q rt C^Q rt < < C^Q rt C^Q CD ^Q rt CQ O O ω rt (Q CD ^Q rt CQ CD CD rt zzzcjυocjcozυuoυυozouoozuυozc υozoυoozooouυozoooooc uzuυouoozυooυoυzcjoo

00 o εoaooεεoεoεoaoaoaoaaoaoaoaoaoaoaoεoεo aoεoaoaooaεoεooεεooεεoaoaoaooεoεεo εoεooεoεaoεε a O o oooεεooεεo ooaaoaoaoaoaooaaooaaoaoaoaoaoεoεoεoεo ft ft ft fi ft ft ft ft ft ft it f ft ft 'i < < ft ft ft < tt ft < ft < < < ft < < ft < < rt ft < ft ft < ft < ft < f_t! ft ft < ft ft f < < < < < < t < <

o υ

d θ ol O oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H ^, (3l (n N ιη H O) ω o <» N ιn ^ d H c^ d d Λ ιn 03 l ιn d ln ^ σl ^ d n ol m ι (^ι aι ln ^ c^ o ιJι ιn t ffl l!l al "^ O CD Φ a! N (») 0 ^ <Λ O ιf) tD "r ln d ' ( ιn ln eo f^ c^l Λ Ol m co ιD co ol ι^ O "» d <ι^ι d co d ln Φ lJι d (D ιn d O OO d ^ ^ H lIl o ^l Ol ιn o Φ Φ ιn d "ι^ι d o o V ( ι « d « o o> oι o ιn Φ ^ » ιΛ n d N ^ _ n o Φ o ιΛ W ^ n lή « ιn o ffl oo ιo » ι^ (O H ιn ^ ιn Φ O N Λ ^ » NΦ O H O » * l M lπ Φ Φ ^ ^ ιn <^⁾ ^" ^o ιΛ f1 ι "f c ^ ^ η (^ cO "r ιn Φ ^ ω ^ d o o lΛ σ o o ffi o o σl O Φ O o ιΛ lD ao o N Pl N ^ Φ Φ Φ ιO { N d O Φ Φ a) (O lO "l^, ^ rl (Jl O O H ιn σ σl al co co ^ -

C-l CM CM CM CM CM CM CM CM CM CM CM CM CN CN CM Cl (N H H CM CM H CN CN H CM H CM CM H H H CM CM CM CM H H H H H H H H H H H H H H H H H H CM CM CM H H H H H H d H

« ω N lB N ( OO Φ n ^l N n ^ ιJl l l ^ H « ln ^ <l' 900 ιO N O Φ 1T "r d f M Φ m ffl O O N n (M d ι n r co c 'T 'P "^ 'r ι ι 'r Φ 4 d oo o H o ιIl o^ ^ H r-- vo co r-- ιn 'r o r ro cM co _> r~ _ι ιn r^ Λ iτι o o H H C cvi iD in vD r^ Ln ιn ιn c ιn ιn ιn "y ιn ιθ ιn

H H CM CM H H H H H H H H H H H H H H H H H H CM CM CM CM CM CM CM H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

⁽Λ N il il' W V M' in in Λ i lO ΦΦ lO IO - rø x>

H H H H H H H H H H H H H H H H H H H U^ C— C-ι l_ι b b l— ι l— ι l_ι l-ι C_ l ι _4 C_ [_ _ι Uι l— ι l_ι [i4 f-ι b l— i l— ι b b l_ι b

EH EH H H O C5 C5 O C5 CJ⁾ CJ⁾ CJ) CJ O CJ⁾ l_ι aι l_ι C< CLι Ciι Pj P- C-ι C-ι C_ CLι C C D D D D D D D D C0 C0 C0 C0 C0 C0 C0 C0 C0 cocococococococo w w w w ni tf ή ca s pύ rt ix ps ή ps a ps tf ei pύ pts ^ ε ε S rt rt rt rt rt rt rt rt rt rt rt EH H EH H EH H H EH HeH eH EH EH H i-l H-l HH Hq HH HH Hl J lJ lJ HH HH HH HH HH HH HH rt rt rt rt rt rt rt rt oo o cj ,_i μi _h-| _t-| j ₁-q _h-l rq

CQ CD Q ld < DQ CD Q W N DC -C ft CQ O Q Q W W W N i^ -; ft CQ C5 Q Q (0 U Q ω N ft DQ CD O Q ft < CQ Q Cd υυiouzυuoυυυzυzzzuuo oo o cj z cj o cj c cj z υυo o u cj cj z cjcj o cj ocj u z zcj o o u cj o z z υ u o z cjcj o υ υ cj υ

Table 3

ATOM 5740 NZ LYS F 196 10.542 53.178 15.150 1.00 41.25 N

ATOM 5741 N GLU F 197 10.991 47.630 19.963 1.00 35.86 N

ATOM 5742 CA GLU F 197 11.047 46.194 19.735 1.00 36.04 C

ATOM 5743 C GLU F 197 11.352 45.921 18.264 1.00 35.04 C

ATOM 5744 0 GLU F 197 10.765 46.539 17.372 1.00 33.77 o

ATOM 5745 CB GLU F 197 9.718 45.535 20.138 1.00 37.85 C

ATOM 5746 CG GLU F 197 9.555 44.092 19.646 1.00 40.50 C

ATOM 5747 CD GLU F 197 8.268 43.420 20.142 1.00 42.49 C

ATOM 5748 OEl GLU F 197 7.216 44.098 20.218 1.00 43.04 o

ATOM 5749 OE2 GLU F 197 8.311 42.207 20.437 1.00 42.34 o

ATOM 5750 N PHε F 198 12.297 45.013 18.033 1.00 34.31 N

ATOM 5751 CA PHε F 198 12.721 44.626 16.695 1.00 33.94 C

ATOM 5752 C PHε F 198 11.964 43.334 16.386 1.00 34.49 C

ATOM 5753 o PHε F 198 12.159 42.328 17.062 1.00 33.96 o

ATOM 5754 CB PHE F 198 14.234 44.373 16.708 1.00 32.03 C

ATOM 5755 CG PHE F 198 14.851 44.172 15.345 1.00 30.37 c

ATOM 5756 CDl PHE F 198 16.076 43.523 15.223 1.00 29.72 c

ATOM 5757 CD2 PHE F 198 14.238 44.659 14.195 1.00 29.77 c

ATOM 5758 CEl PHE F 198 16.688 43.359 13.965 1.00 29.73 c

ATOM 5759 CE2 PHE F 198 14.840 44.500 12.936 1.00 30.25 c

ATOM 5760 CZ PHE F 198 16.071 43.847 12.828 1.00 28.74 c

ATOM 5761 N LYS F 199 11.099 43.372 15.377 1.00 35.60 N

ATOM 5762 CA LYS F 199 10.304 42.204 14.994 1.00 36.11 c

ATOM 5763 C LYS F 199 10.760 41.601 13.675 1.00 35.77 C

ATOM 5764 o LYS F 199 11.331 42.293 12.836 1.00 35.67 o

ATOM 5765 CB LYS F 199 8.825 42.584 14.896 1.00 36.91 C

ATOM 5766 CG LYS F 199 8.226 43.120 16.196 1.00 38.98 c

ATOM 5767 CD LYS F 199 6.748 43.447 16.026 1.00 40.85 c

ATOM 5768 CE LYS F 199 6.103 43.833 17.358 1.00 42.06 c

ATOM 5769 NZ LYS F 199 4.614 43.950 17.244 1.00 42.75 N

ATOM 5770 N GLN F 200 10.490 40.308 13.502 1.00 35.69 N

ATOM 5771 CA GLN F 200 10.855 39.582 12.295 1.00 35.41 C

ATOM 5772 C GLN F 200 10.372 40.266 11.021 1.00 35.51 C

ATOM 5773 o GLN F 200 11.083 40.306 10.027 1.00 35.58 o

ATOM 5774 CB GLN F 200 10.288 38.155 12.351 1.00 34.06 C

ATOM 5775 CG GLN F 200 10.978 37.228 13.347 1.00 31.65 C

ATOM 5776 CD GLN F 200 12.453 37.037 13.039 1.00 29.88 C

ATOM 5777 OEl GLN F 200 12.855 37.003 11.878 1.00 29.84 o

ATOM 5778 NE2 GLN F 200 13.261 36.889 14.080 1.00 29.62 N

ATOM 5779 N GLU F 201 9.166 40.821 11.059 1.00 36.04 N

ATOM 5780 CA GLU F 201 8.593 41.469 9.887 1.00 36.60 C

ATOM 5781 C GLU F 201 9.204 42.833 9.576 1.00 35.96 C

ATOM 5782 o GLU F 201 8.845 43.461 8.579 1.00 35.12 o

ATOM 5783 CB GLU F 201 7.082 41.619 10.071 1.00 37.56 C

ATOM 5784 CG GLU F 201 6.709 42.533 11.220 1.00 41.31 C

ATOM 5785 CD GLU F 201 6.054 41.798 12.385 1.00 44.04 C

ATOM 5786 OEl GLU F 201 6.638 40.813 12.917 1.00 43.75 o

ATOM 5787 OE2 GLU F 201 4.945 42.224 12.775 1.00 45.55 o

ATOM 5788 N HIS F 202 10.124 43.296 10.420 1.00 35.49 N

ATOM 5789 CA HIS F 202 10.751 44.597 10.196 1.00 35.12 C

ATOM 5790 C HIS F 202 11.755 44.647 9.038 1.00 34.73 C

ATOM 5791 o HIS F 202 12.200 45.730 8.653 1.00 35.10 o

ATOM 5792 CB HIS F 202 11.409 45.115 11.481 1.00 35.18 C

ATOM 5793 CG HIS F 202 10.434 45.600 12.513 1.00 35.87 C

ATOM 5794 ND1 HIS F 202 9.222 46.175 12.185 1.00 36.51 N

ATOM 5795 CD2 HIS F 202 10.504 45.623 13.866 1.00 34.64 C

ATOM 5796 CEl HIS F 202 8.590 46.527 13.289 1.00 35.55 C

ATOM 5797 NE2 HIS F 202 9.348 46.204 14.324 1.00 35.01 N

ATOM 5798 N ARG F 203 12.115 43.487 8.488 1.00 33.96 N

ATOM 5799 CA ARG F 203 13.035 43.430 7.341 1.00 33.38 C

ATOM 5800 C ARG F 203 12.815 42.138 6.550 1.00 33.55 C

ATOM 5801 o ARG F 203 12.358 41.135 7.103 1.00 32.74 o

ATOM 5802 CB ARG F 203 14.512 43.525 7.795 1.00 30.83 C

ATOM 5803 CG ARG F 203 15.093 42.255 8.435 1.00 29.74 C

ATOM 5804 CD ARG F 203 16.514 42.509 8.978 1.00 29.31 c

ATOM 5805 ε ARG F 203 17.452 42.893 7.923 1.00 26.83 N oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

HHHHHHHHHHH HHHHHHHH H H H H H H H , σiCDCDCMHCOHCΛ ooc c_M i'r-oor- "rσiHΦnomrM r-r-cDm ιιnιncMC Mmιr)r~r~r-_"σ» σiHH M M r c ' ιcoιnιoro( ιnιn< HHσ>cocor~σ5θθθ3<Λoooo<τ>oocoH<Mi^, 'j^,roco< <M( roro«j'CMCM

HHHHHHHHHHH HHHHHHHHHCMCMHCMCMCMCMCMCMCMCMCMCMCMCMCMCM l oo(<llo( l mln^( »ιn(Dp•lnoo^« (MO_HΦOo eom (IlΛΦιn (M H^^MΦ^^ι^ι ^ f l "lⁱmHΦ(MHO n m< Φ_ nN^ CoooιηNΦ ooo»ιnιΛO(ΛHnιBd ιo1^<ι^|ιnΦlnιnNdι^,)(Mc^,)ι^,)lJl^ ^>ι^|OOdO\ι_ι<)ιIl ιo<DO(I^d<l^|(nι ln^^Λ Oιηnnι1l o »dmooHN^ffl ι ιnΦ^ΦβΦriHoι^ON9Noo»oβo»NΦlnN^OBnιΛ«NΛ«βoono^HΦn Hll)ι^,ιιnHι<)«»Λι»βιnΦ r~ Mθ M MoσιoHCMσιcMoot~r~ιoα3<x)oocΛcor--iDioσ)σ>ocoom<τ>ovDinι cD'r(ori MHi ιnro Minι [~rocj( W 00 ι»ιi'^ιi'rf i'r ιro«^ or or (θr ror r rnιor ro π r ror 'rι^ θf fOf r r rocor r ro c

"f d

!B

H

nι<1n« « « « '« « v « ιl)ιn ι')ιnΦWΦΦ ^ ^• r' og ι.ωo ιDaD lso πΦ nιIιoι 9ιolo oooo dd rl H^l H Hrl(4C4M lMC4n

O OOO O OO O O O O O OOO O O O O O O O O O O O O O O OO OO O OO OO O O O O O O O O O H H H H H H H H H H H H H H H H H H H CMCMCMCMCMcgCMCMC cM CMCMClCMCMCN CM CM CM rM rM CM CM CM CM CM CM CM CM C^ CM CM CM CM CM CM CM CM CMCM CM CMCM CM CM N o ) θ i_ι ω ω ω t-i M ω ω >H >H >< H < 4 < ι c; c; pc; c; o5 c; pύ ps ps pc; pc; s

« Λ « !-l H^ Hj Hl ₁J h-| ₁-1 ^ J pl _H3 H _Hq _Hj _{HH r}H >H >H _< H 1 , >H >H l !H H >H H H l H >₁ , _< H

<SSH HHH HHHH . - t5UU . U Uh Hh HEι HH h h EH h JJ J JJ JJdJ>> > > > 3 S SS 5! «< < < ι<U U - 0(5S

H CM H CM H H CM H CM H CM H CM

N I - ft _Λ C^Q CD 0 ^Q < ft < „ C5 ^{Q Q} U W N K ft CQ Q W N ft CQ CD CD ft CQ < CQ O Q Q ft CQ

CJ Z Z Z O O O CJ U CJ CJ Z O O O Z CJ O O Z O O O O O O U U CJ CJ O Z O CJ O U O CJ CJ Z Z CJ O O O U CJ Z U CJ O O Z O U O O U O Z Z O O O O Z

υooυzuuouυcjozυoouuzυυooozυooυoouzuuououuzuuouucouzuuouoυoozυυoc ozυu

d ιn Λ o_oooooo_ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

I H H H H H H H H H H H H

(M ^^, (^,^ ^ (^,) co o cι ^ ^ O H ^^t ιO c (Λ ω ^ d ^ ^ ιn f ιn ^^ f" "r a)O O N ^ *^^, ^ (η ^ ω d ιΛ C ιn oΛ H ^ Φ CD n ln d H O ^ ^ H (η π Φ (^ <η ω H n H ln oo m ιf on » ιn o c^ι o M ln m ln n "f ω Φ (M "l^,Φ ιn ιΛ O« d lΛ ^ι ^ n » n w ι » ι1 ιΛ » Φ ln o (^,1 H Φ Oo ^ "|^| (M <l^| O H ^l' ⁽M w d (D ^r ^ Φ ^ H n Φ nffl nιo » r• ιn n ln Φ « o Φ ι^,) o oι β β Λ « o o <ι> (D ^ nΦ O ⁽Λ Φ « O H ιo o ιfl ι^l1 n ⁽^ι ^^, ^ P⁾ ιn ^(,) H » oι ⁽l Λ N ιπ ι^,) d c^l H O ^ι ^ d ιf lΛ ιπ ^ <D ^ ω o σ^ a^ ιD ϋo co ^ ιπ ιO Φ l) ιn t^) v (^,^ cι H (M (^ f d <Jl a) (]o O H d O ^ ιn ι Φ r• ^ ^" ^ ^ (^,^ ( W N d ^ v f^,^

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H H H H H H H H H H H H H H H H H H H H H H H H H H ffl o ω 90 ^ ^ O ^ d ω » ^ lD l(l 0 ^ σl ln "f d n oo o (M N ι^,) (M ^ Ol ιD ^ ιD a) N "l^l ^^ ιn o ^ "ι^, ιn ^ ιn cι ιn ⁽1 ιn N lI) 0 '» H d Φ ^ ιIl ι^,) ^ ιn φ <* n ω ω "l' ^ ιn m » c^ ^ o o N ι d ^ι ^ l ^ ιn o N ln ( ^' ln n ln co d N d H ln o^ H ι ι^,) ι^,l o o ιn ^ι d d ^ N o H ^ o σl o <Iι ιI) -) ω ι<l ιn lO O (^ c^ N "f Λ n '» ^n n (Λ ιo ol o Φ <>ι oo o co ιn ω ( H ^ H n Φ n H ^ι "» <» ^βl ^ o^ ln o ι^ι a! Φ ιη ^ π« ω a⁾ Λ Φ O) ιn n o ln a) n o N Φ ln 00 f^ ιn ιn n ln ^ cD ^ ιn "f ιn ι Φ ιn Φ ^ ^ Φ ln o ol m Λ O H O ( lo oo (.03 Φ 'f Λ m m o H H ^ co a) σl ιJl lO "f » n a o H H σl oo ιM (η "^ 00 ro r ro co r c c rθ ( rθ ( fθ c f co m ro r rθ ( o ro ro ιi "_« ι ιι ro r ro ιη ro ^

H CM ft < (O O a Q H H M N N I rt (Q CD rt HOQ Q rt CQ CD CD a ft CQ CD Q W ft DQ CD Q C-l l-l ft PQ CD <

U CJ O U Z U U O U O U U Z O O O O O Z CJ CJ O CJ O Z O O O O O O O Z U O O O U CJ O Z CJ CJ O U U W O Z U O O O O O O O Z O O O U O Z O O

i i i in in i in in in in i in in in in n in i in i i i in in in in i i in in inin in i iO in io in in in in in in in

© aaaεsεaεaεεεεεεaaaaaaaaaaaεεεεεεεεεaaaaεεaaaaaaaaaaaasaεsaaaaaaaaa

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O tι t< H H H < H tH h H H h tι h E< h EH t H H H H tι h h h H H H H ^ < tι tι tH h E< h t< H Fι tι < tι E< h t< t< h H tι H EH EH tH tι EH tι B t< t EH rtrtrtrtrtrtrtrtrtrtrtrtrt^rtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrt

Tab 3

ATOM 5938 o VAL F 221 22.542 44.370 2.293 1.00 29.53 0

ATOM 5939 CB VAL F 221 22.971 44.284 5.594 1.00 28.01 c

ATOM 5940 CGI VAL F 221 23.139 43.337 6.781 1.00 26.11 c

ATOM 5941 CG2 VAL F 221 24.324 44.609 4.983 1.00 26.82 c

ATOM 5942 N VAL F 222 20.988 45.533 3.449 1.00 29.96 N TOM 5943 CA VAL F 222 20.716 46.507 2.404 1.00 31.14 C

ATOM 5944 C VAL F 222 20.671 47.892 3.056 1.00 32.51 C

ATOM 5945 o VAL F 222 20.606 48.007 4.281 1.00 32.13 o

ATOM 5946 CB VAL F 222 19.341 46.236 1.704 1.00 31.92 c

ATOM 5947 CGI VAL F 222 19.393 44.934 0.889 1.00 32.22 c

ATOM 5948 CG2 VAL F 222 18.229 46.149 2.749 1.00 30.96 c

ATOM 5949 N PRO F 223 20.717 48.961 2.242 1.00 33.33 N

ATOM 5950 CA PRO F 223 20.678 50.337 2.744 1.00 33.05 C

ATOM 5951 C PRO F 223 19.621 50.612 3.808 1.00 32.75 C

ATOM 5952 o PRO F 223 19.888 51.306 4.779 1.00 31.69 o

ATOM 5953 CB PRO F 223 20.449 51.149 1.472 1.00 32.99 C

ATOM 5954 CG PRO F 223 21.301 50.414 0.489 1.00 33.35 C

ATOM 5955 CD PRO F 223 20.963 48.949 0.786 1.00 33.24 C

ATOM 5956 N SER F 224 18.428 50.051 3.636 1.00 32.51 N

ATOM 5957 CA sεR F 224 17.348 50.278 4.584 1.00 31.69 C

ATOM 5958 C sεR F 224 17.599 49.727 5.999 1.00 31.73 C

ATOM 5959 o sεR F 224 16.884 50.077 6.937 1.00 31.16 o

ATOM 5960 CB SER F 224 16.057 49.697 4.013 1.00 31.66 C

ATOM 5961 OG SER F 224 16.199 48.307 3.774 1.00 32.99 o

ATOM 5962 N ASP F 225 18.604 48.867 6.160 1.00 31.38 N

ATOM 5963 CA ASP F 225 18.912 48.311 7.484 1.00 30.26 C

ATOM 5964 C ASP F 225 19.669 49.309 8.378 1.00 30.11 C

ATOM 5965 0 ASP F 225 19.874 49.068 9.570 1.00 28.77 o

ATOM 5966 CB ASP F 225 19.741 47.028 7.364 1.00 29.82 C

ATOM 5967 CG ASP F 225 18.952 45.864 6.793 1.00 29.68 C

ATOM 5968 ODl ASP F 225 17.802 45.623 7.242 1.00 28.36 o

ATOM 5969 OD2 ASP F 225 19.500 45.174 5.909 1.00 27.10 o

ATOM 5970 N LYS F 226 20.089 50.429 7.797 1.00 30.34 N

ATOM 5971 CA LYS F 226 20.809 51.438 8.566 1.00 30.46 C

ATOM 5972 C LYS F 226 19.980 51.868 9.778 1.00 30.07 c

ATOM 5973 o LYS F 226 18.763 52.049 9.667 1.00 29.46 o

ATOM 5974 CB LYS F 226 21.134 52.656 7.691 1.00 31.03 c

ATOM 5975 CG LYS F 226 21.782 53.802 8.481 1.00 32.45 c

ATOM 5976 CD LYS F 226 22.034 55.040 7.619 1.00 33.36 c

ATOM 5977 CE LYS F 226 22.717 56.153 8.434 1.00 34.79 c

ATOM 5978 NZ LYS F 226 23.090 57.326 7.587 1.00 35.90 N

ATOM 5979 N GLY F 227 20.644 52.018 10.928 1.00 28.53 N

ATOM 5980 CA GLY F 227 19.955 52.421 12.142 1.00 28.88 C

ATOM 5981 C GLY F 227 20.679 51.982 13.403 1.00 29.17 C

ATOM 5982 o GLY F 227 21.838 51.556 13.346 1.00 28.63 o

ATOM 5983 N ASN F 228 20.012 52.102 14.546 1.00 28.73 N

ATOM 5984 CA ASN F 228 20.608 51.697 15.815 1.00 29.18 C TOM 5985 C ASN F 228 20.029 50.382 16.314 1.00 28.27 C

ATOM 5986 o ASN F 228 18.821 50.157 16.229 1.00 28.24 o

ATOM 5987 CB ASN F 228 20.386 52.755 16.888 1.00 31.52 C

ATOM 5988 CG ASN F 228 20.888 54.112 16.469 1.00 33.14 C

ATOM 5989 ODl ASN F 228 21.966 54.241 15.897 1.00 34.19 o

ATOM 5990 ND2 ASN F 228 20.108 55.138 16.760 1.00 34.39 N

ATOM 5991 N TYR F 229 20.902 49.521 16.832 1.00 26.46 N

ATOM 5992 CA TYR F 229 20.502 48.229 17.374 1.00 25.52 C

ATOM 5993 C TYR F 229 21.014 48.118 18.801 1.00 25.73 C

ATOM 5994 o TYR F 229 22.227 48.156 19.062 1.00 25.37 o

ATOM 5995 CB TYR F 229 21.034 47.088 16.505 1.00 23.62 C

ATOM 5996 CG TYR F 229 20.487 47.141 15.104 1.00 24.17 C

ATOM 5997 CDl TYR F 229 21.007 48.028 14.167 1.00 24.31 C

ATOM 5998 CD2 TYR F 229 19.383 46.368 14.735 1.00 24.16 C

ATOM 5999 CEl TYR F 229 20.429 48.154 12.901 1.00 25.39 C

ATOM 6000 CE2 TYR F 229 18.811 46.482 13.488 1.00 22.86 C

ATOM 6001 CZ TYR F 229 19.325 47.374 12.576 1.00 24.60 C

ATOM 6002 OH TYR F 229 18.706 47.529 11.356 1.00 26.12 o

ATOM 6003 N THR F 230 20.069 47.979 19.724 1.00 25.46 N u o u o

of d ooιη _

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H H H H H , I H H H H H H H H H H H H H , I rH ri ri r o m co ω flι 1iι'ιnN H lM OΦ d N ι^,^ι^,)ι^,^flo ι^1 ι ιn ι^,) ι^,ι ι»ld CM C CO < ΓO <O OO ( ΓO CO C Γ ΓO CO CO

O cn ro

O ooo coι»ι-_ mm(!l σι σ* ro <o ro r Pi n π π π π π i'l O fO M CMCl CM CM CM CM CM CM CM CM CM CM CM ki t hi bi ti i i ln bn ln A i bi oi cύ tύ Pi i ςύ ac x 3- X W X r^{H H H H} !^H >^H rt rt rt rt rt rt rt rt rt rt rt < a a

> CωO CωO COωCO CwO CQ H CM H CM H CM ft CQ CD CD rt CQ CD rt CQ D CD rt CQ CD CD rt PQ < cQ C Q Q ft co < cQ o α α ω ω N K rt <: ∞ D υooooozυoooiozuoouuozoooυυuzcjuoo z υ c o υ o o z z υ u o υ z o o o υ o o o o o o o z u o o z o o o o o

Table 3

ATOM 6070 N ILE F 240 21.009 46.234 31.958 1.00 30.55 N

ATOM 6071 CA ILE F 240 22.032 47.020 31.277 1.00 29.37 C

ATOM 6072 C ILE F 240 21.857 46.909 29.766 1.00 28.68 C

ATOM 6073 o ILE F 240 21.298 45.928 29.274 1.00 29.57 o

ATOM 6074 CB ILE F 240 23.441 46.524 31.671 1.00 28.30 C

ATOM 6075 CGI ILE F 240 23.599 45.056 31.276 1.00 29.24 C

ATOM 6076 CG2 ILE F 240 23.632 46.649 33.186 1.00 26.87 c

ATOM 6077 CDl ILE F 240 25.001 44.480 31.564 1.00 30.18 c

ATOM 6078 N ASN F 241 22.330 47.913 29.031 1.00 27.35 N

ATOM 6079 CA ASN F 241 22.214 47.917 27.579 1.00 25.92 C

ATOM 6080 C ASN F 241 23.425 48.525 26.885 1.00 26.07 C

ATOM 6081 o ASN F 241 24.235 49.227 27.503 1.00 24.87 o

ATOM 6082 CB ASN F 241 20.957 48.672 27.141 1.00 24.51 c

ATOM 6083 CG ASN F 241 20.884 50.075 27.724 1.00 25.67 c

ATOM 6084 ODl ASN F 241 20.311 50.290 28.796 1.00 28.27 o

ATOM 6085 ND2 ASN F 241 21.488 51.033 27.036 1.00 24.93 N

ATOM 6086 N HIS F 242 23.527 48.243 25.589 1.00 25.58 N

ATOM 6087 CA HIS F 242 24.613 48.730 24.747 1.00 25.88 C

ATOM 6088 C HIS F 242 24.040 48.965 23.356 1.00 26.14 C

ATOM 6089 o HIS F 242 23.170 48.213 22.907 1.00 25.21 o

ATOM 6090 CB HIS F 242 25.726 47.695 24.656 1.00 26.14 C

ATOM 6091 CG HIS F 242 26.838 48.095 23.741 1.00 26.54 C

ATOM 6092 ND1 HIS F 242 27.732 49.097 24.052 1.00 26.56 N

ATOM 6093 CD2 HIS F 242 27.196 47.632 22.521 1.00 27.55 C

ATOM 6094 CEl HIS F 242 28.598 49.231 23.063 1.00 28.63 C

ATOM 6095 NE2 HIS F 242 28.296 48.353 22.122 1.00 28.19 N

ATOM 6096 N THR F 243 24.542 49.980 22.663 1.00 25.54 N

ATOM 6097 CA THR F 243 24.025 50.303 21.342 1.00 26.51 C

ATOM 6098 C THR F 243 25.042 50.299 20.210 1.00 27.85 C

ATOM 6099 o THR F 243 26.136 50.842 20.343 1.00 28.40 o

ATOM 6100 CB THR F 243 23.316 51.690 21.356 1.00 26.25 C

ATOM 6101 OG1 THR F 243 22.214 51.657 22.273 1.00 24.68 o

ATOM 6102 CG2 THR F 243 22.793 52.048 19.958 1.00 26.04 C

ATOM 6103 N TYR F 244 24.664 49.664 19.103 1.00 28.22 N

ATOM 6104 CA TYR F 244 25.496 49.602 17.909 1.00 29.85 C

ATOM 6105 C TYR F 244 24.807 50.413 16.816 1.00 31.08 C

ATOM 6106 o TYR F 244 23.583 50.536 16.800 1.00 30.67 o

ATOM 6107 CB TYR F 244 25.659 48.168 17.398 1.00 29.24 c

ATOM 6108 CG TYR F 244 26.503 47.274 18.264 1.00 29.23 c

ATOM 6109 CDl TYR F 244 25.934 46.213 18.969 1.00 28.57 c

ATOM 6110 CD2 TYR F 244 27.882 47.476 18.370 1.00 28.39 c

ATOM 6111 CEl TYR F 244 26.715 45.370 19.754 1.00 28.64 c

ATOM 6112 CE2 TYR F 244 28.669 46.644 19.158 1.00 29.07 c

ATOM 6113 CZ TYR F 244 28.081 45.593 19.846 1.00 28.99 c

ATOM 6114 OH TYR F 244 28.859 44.775 20.630 1.00 30.62 o

ATOM 6115 N HIS F 245 25.601 50.973 15.913 1.00 32.15 N

ATOM 6116 CA HIS F 245 25.069 51.741 14.797 1.00 33.59 c

ATOM 6117 C HIS F 245 25.457 50.986 13.534 1.00 33.68 c

ATOM 6118 o HIS F 245 26.611 50.581 13.387 1.00 33.99 o

ATOM 6119 CB HIS F 245 25.674 53.145 14.786 1.00 34.56 c

ATOM 6120 CG HIS F 245 25.480 53.882 16.077 1.00 37.38 c

ATOM 6121 ND1 HIS F 245 24.287 54.476 16.421 1.00 37.28 N

ATOM 6122 CD2 HIS F 245 26.310 54.066 17.132 1.00 39.21 C

ATOM 6123 CEl HIS F 245 24.385 54.991 17.636 1.00 37.94 C

ATOM 6124 NE2 HIS F 245 25.606 54.753 18.090 1.00 38.49 N

ATOM 6125 N LEU F 246 24.499 50.777 ^• 12.638 1.00 33.16 N

ATOM 6126 CA LEU F 246 24.778 50.063 11.399 1.00 33.00 C

ATOM 6127 C LEU F 246 24.638 50.957 10.174 1.00 34.03 C

ATOM 6128 o LEU F 246 23.694 51.746 10.065 1.00 34.12 o

ATOM 6129 CB LEU F 246 23.842 48.854 11.246 1.00 31.62 C

ATOM 6130 CG LEU F 246 23.884 48.127 9.894 1.00 31.04 C

ATOM 6131 CDl LEU F 246 25.269 47.475 9.679 1.00 30.18 C

ATOM 6132 CD2 LEU F 246 22.789 47.071 9.849 1.00 29.52 C

ATOM 6133 N ASP F 247 25.592 50.834 9.257 1.00 34.91 N

ATOM 6134 CA ASP F 247 25.560 51.598 8.018 1.00 36.30 C

ATOM 6135 C ASP F 247 25.917 50.642 6.887 1.00 36.31 C Table 3

ATOM 6136 o ASP F 247 26.820 49.813 7.036 00 36.41 O

ATOM 6137 CB ASP F 247 26.540 52.777 8.075 00 36.95 C

ATOM 6138 CG ASP F 247 26.118 53.919 .161 00 38.99 C

ATOM 6139 ODl ASP F 247 26.603 55.059 .335 00 39.74 O

ATOM 6140 OD2 ASP F 247 25.288 53.672 .262 00 40.23 O

ATOM 6141 N VAL F 248 25.196 50.740 .771 00 36.55 N

ATOM 6142 CA VAL F 248 25.430 49.864 .633 00 36.46 C

ATOM 6143 C VAL F 248 25.844 50.650 3.400 00 36.82 C

ATOM 6144 0 VAL F 248 25.231 51.664 3. 070 00 37.84 O

ATOM 6145 CB VAL F 248 24.167 49.053 4. 312 1.00 36.17 C

ATOM 6146 CGI VAL F 248 24.465 48.007 3. 249 1.00 34.16 C

ATOM 6147 CG2 VAL F 248 23.643 48.411 5. 592 00 35.63 C

ATOM 6148 N VAL F 249 26.889 50.171 2. 726 00 36.57 N

ATOM 6149 CA VAL F 249 27.415 50.820 1. 527 00 36.43 C

ATOM 6150 C VAL F 249 27.369 49.875 0. 325 00 36.89 C

ATOM 6151 o VAL F 249 27.897 48.761 0. 371 00 36.55 o

ATOM 6152 CB VAL F 249 28.898 51.264 1.735 1.00 36.50 c

ATOM 6153 CGI VAL F 249 29.419 51.953 0.480 1.00 35.80 c

ATOM 6154 CG2 VAL F 249 29.013 52.186 2.933 1.00 35.90 c

ATOM 6155 N GLU F 250 26.750 50.323 0.756 1.00 36.94 N

ATOM 6156 CA GLU F 250 26.664 49.503 -1 953 1.00 36.91 C

ATOM 6157 C GLU F 250 27.923 49.681 -2 792 1.00 35.51 C

ATOM 6158 o GLU F 250 28.315 50.796 -3 100 1.00 35.05 O

ATOM 6159 CB GLU F 250 25.419 49.902 -2.747 1.00 39.01 C

ATOM 6160 CG GLU F 250 24.131 49.722 -1.952 1.00 42.23 C

ATOM 6161 CD GLU F 250 22.889 50.095 -2.742 1.00 43.94 C

ATOM 6162 OEl GLU F 250 22.643 51.304 -2.949 1.00 44.73 o

ATOM 6163 OE2 GLU F 250 22.165 49.169 -3.159 1.00 44.81 o

ATOM 6164 N ARG F 251 28.561 48.573 -3.149 .00 34.53 N

ATOM 6165 CA ARG F 251 29.776 48.607 -3.948 ,00 33.88 C

ATOM 6166 C ARG F 251 29.417 48.222 -5.380 ,00 35.00 C

ATOM 6167 o ARG F 251 28.527 47.416 -5.595 ,00 34.89 O

ATOM 6168 CB ARG F 251 30.804 47.628 -3.379 .00 31.60 C

ATOM 6169 CG ARG F 251 31.185 47.893 .923 1.00 28.57 C

ATOM 6170 CD ARG F 251 31.457 49.373 .673 1.00 26.81 C

ATOM 6171 NE ARG F 251 32.497 49.913 .550 1.00 24.43 N

ATOM 6172 CZ ARG F 251 33.800 49.670 .431 ,00 22.96 C

ATOM 6173 NHl ARG F 251 34.269 48.885 .463 .00 24.68 N

ATOM 6174 NH2 ARG F 251 34.642 50.229 .280 .00 24.66 N

ATOM 6175 N SER F 252 30.098 48.796 -6.362 .00 35.23 N

ATOM 6176 CA SER F 252 29.834 48.520 -7.772 ,00 36.16 C

ATOM 6177 C SER F 252 31.103 48.052 -8.482 ,00 36.13 C

ATOM 6178 o SER F 252 31.930 48.859 -8.882 1.00 36.17 O

ATOM 6179 CB SER F 252 29.299 49.794 -8.433 1.00 36.21 C

ATOM 6180 OG SER F 252 29.342 49.697 -9.841 1.00 37.53 O

ATOM 6181 N PRO F 253 31.269 46.739 -8.660 1.00 37.26 N

ATOM 6182 CA PRO F 253 32.471 46.219 -9.326 1.00 37.37 C

ATOM 6183 C PRO F 253 32.490 46.310 -10.859 1.00 37.89 C

ATOM 6184 o PRO F 253 32.809 45.334 -11.539 1.00 39.08 O

ATOM 6185 CB PRO F 253 32.539 44.784 -8.820 1.00 38.19 C

ATOM 6186 CG PRO F 253 31.080 44.407 -8.743 1.00 37.95 C

ATOM 6187 CD PRO F 253 30.429 45.643 -8.134 1.00 37.11 C

ATOM 6188 N HIS F 254 32.153 47.479 -11.400 1.00 37.46 N

ATOM 6189 CA HIS F 254 32.164 47.669 -12.847 1.00 37.94 C

ATOM 6190 C HIS F 254 33.273 48.623 -13.293 1.00 36.74 C

ATOM 6191 o HIS F 254 33.769 49.419 -12.504 .00 36.07 O

ATOM 6192 CB HIS F 254 30.828 48.236 -13.339 .00 39.88 C

ATOM 6193 CG HIS F 254 29.663 47.320 -13.131 ,00 43.40 C

ATOM 6194 ND1 HIS F 254 28.911 47.319 -11.973 ,00 45.10 N

ATOM 6195 CD2 HIS F 254 29.129 46.364 -13.928 ,00 43.84 C

ATOM 6196 CEl HIS F 254 27.962 46.404 -12.068 .00 44.84 C

ATOM 6197 NE2 HIS F 254 28.072 45.811 -13.244 .00 45.80 N

ATOM 6198 N ARG F 255 33.665 48.530 -14.559 .00 35.84 N

ATOM 6199 CA ARG F 255 34.663 49.440 -15.092 1.00 35.46 C

ATOM 6200 C ARG F 255 33.904 50.769 -15.210 1.00 34.55 C

ATOM 6201 o ARG F 255 32.676 50.787 -15.132 1.00 34.11 O o o n θ o θ o r c f r ιoco< o θ θr t r^ oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

nHro"^"|m(nσ^a)OlN ΦιJιn>l^,N Nnool^H<JlnooHoo ^ ooι HlJ^lMιn ^ι H ^ OΦN ^ lf^HO <ιι oc^lHco"^H ιιnoocMO Φron^_OlnωωolOιJ lnoΦH^flO_N H ι^coooωιnn^_N Hσ\^_Mπ)H >^cι)ιΛnιJl^^ll^coιη^Illnπ^ιoHa)ιηo»(^ι^I ιn^ιdHr'^oolHwιn vln<JlOιnσl"rn"^ ΦN"^n( Φω ιnl coσι>»σl^ ΦΦ!M<I\n<I ι o^^HOM'»o>ιo<Λn no^o (MC βllnffl^ιooH o^ι»ιιn^!D ^•lDOomdlnιnΦMn ιnΦ^^ ^•ln-)ιnιJlooodlJιo^od ιmooιJ H^ι(o»n«ι ιn<ⁱ"f"l^|(π^ dr^lnlnr■^φφln^o^m

H H H CM CM H CM H H H H H H H H H H H H H H H H H H CM CM CM CM H H CN CN CM H CM CN H C CM Csl CM CM CM Cl CM CM Csl M CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I ro σι ro d ω oo (o ^ (0 (0 ^ ln H o ^ ιn N Ol Φ ln σl o ιB ln a> CM H ω o ω ιn n "^ n ^ » _ ^ n tI) ω n ln ιO lD ln <Λ ^ H ln N oo ( ^ <D l!^ ιJl ln ln H ^ ^ ιJl (^ _ ιfl ri Φ Φ d n c^ d O ιn n ^ ^ "^ ι0 V 'ιr <» "ll U) ι«) < (M O a) d O O 00 l ln d lD d "l^ι H ι o d ι n « σ) ln o ln m o n n p^ <ιι H ^f ι<) ^ d ^ ^ (M ri ri ^ (» IJl ^ ri Φ m oJ O O d 0 ^ ιι⁾ ιn 1n n <^ d ^l H^ ι»l Ol N n ^ «1 ^l' ιn ri o ι» 'l^, n "^ o d o o> d lIl » n v ιo N n ^ ffl Ol (o o ^ ιo ι- ιιl H ^ o ^^ ll⁾ ln ιn ^ v ι^ N ^| [M w n (M π u^ Φ Φ H Oo o ol m ω ω o o <Baι H (^ι M <^ι1 co r^■ ^ co ιn ln ιn ll u^ ιn « Φ ^ φ m o o o^ ^ ^ ω d H O O ( ( ^ o w o fO f C C r ro < C rO CO rO C C f f rO CO C CM C\| CM CM rO c CM CM rO CO O ( CM CM CM CM CM CM CM CN CM CM CM C^

ιn ιn l ln ιn ln ι Φ ^ ^ ^ ^ ^ a^{) (}lJ aJ ra m D l» oo ι! Φ lJl lIl ιTl m <J> m *o o o o o d H H H (M (M N N N ( (M ( (^ ι^,l ι») n ιη m n '» « "l^l ιn ιn m ιo ι⁾ ιn ι ιπ tn ι ⁾ ι/ι <i⁾ ιn ι) ιn ι ⁾ ιn m ιn ιo ι ιπ ιθ ιo ιo ιn ιn ι ti) tπ Ln ιθ ι ιn ιθ ι ιθ ιrι ι) Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ

CN CM CN CM CM CM CM CM CM CM CM CN CM CM CM CM CN CM CM CN CN CM CM CM CN CM CM CM CM W CN CM CM CM W

E— i C— C— 4 I--4 C—4 I—-) [—4 f—4 E— j fJE-ι t_f c-ι fj_t E— - 1 (_■ _-« -j [_■ C_ι E_ι |_4 E_ι (_ι c_ι C_ι C_ι [_ι C—i [— 4 C—i c_ι [_. ) C-ι [-ι E_ [-ι l-ι l_ι ^ ^ μ tι ^ b D E_ u [-j E_ _ [_ ι C_ I^ Ew E-ι b b b E_ C-ι [-ι C_ -ι c CDDUOoϋuCDcCiD>oCDoCDoOoOoOoO oOoOoOωCd ωω ωω ωω ωω ωω ωC-i ωω DO DO DDDO DD DD DD DDzZ zZzZ zZ zZ zZ zZ zZ zZ rt rt rt rt rt :H 4 r^

Λ cύΛ cύcύ fi &(ύ Λ ύ Pi iΛ ύΛ ^ ^ ^ <^<^ ^ Α ^ a ui ω i a ui ω ω ^ ^ ^ ^ ^ ^ ^ > ^ι < J j J J .-I J J W W W M M I-I Cd W O- OS C- CS Bi rt Ptf rH PJ HH rt rt rt rt rt rt rt Cij C Dj Cii ij H H H H H H H H Hl H^ Hl Hl t-l Hl Hl Hl D O O C CD C D D )

H CM H CM H H CM H CM H CM

CO CD O W N BC K ft PQ CD O PQ CD CD Q ft PQ CD Q Q rt ω Q W ω ft CQ < ft CQ CD Q Q ft CQ CD Q rt c^joozυzzzoooυoυzocjououυzc uoc ouuzoooouoozzυoocjzuoozoooucjuuz uuouc uzuυ

N n "» ln ^ ω m o H M n "l^, ln Φ ^ oo m o H ^l (^ "l' ιO Φ ^ ^o <Il O d ! n 'I^| ln Φ oo cJ OH <M n ι^| ιnΦ ιIl m o H (M n "^ ιn ^ α! σl O d (M '^ "^ ln Φ o o o o o o o o d d d d d d d d N N (M N ( N N N N w r^|)n n n m m π n ι»i Pi "i^| » fl^, » « 'i^| v "r '* 9 in ιn ιn ιn ιn ιn ι) ιn «) in Φ Φ Φ Φ

00 CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rH Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ IP Φ Φ Φ Φ D ID Φ Φ CD Φ Φ ΦΦ Φ O Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ o aεaassεssaaEaa εEεasssaass00ss0g0s0s0s0s0s0s00ss00s0εs00s0s0sa0s00E o 0000000000000000000000000 0E it ft < < < < < < < < < < < < < < < ft < < < < < < < < < < < < < < < ft ft ft ft ft ft < < ft

Table 3

ATOM 6268 o ALA F 264 31, ,480 66.958 -29.588 1.00 41.01 0

ATOM 6269 CB ALA F 264 28, .456 66.512 -28.477 1.00 40.32 c

ATOM 6270 N ASN F 265 30, .192 65.881 -31.093 1.00 42.16 N

ATOM 6271 CA ASN F 265 30, .925 66.408 -32.237 1.00 43.51 C

ATOM 6272 C ASN F 265 30. .826 67.928 -32.203 1.00 44.31 C TOM 6273 o ASN F 265 29. .859 68.485 -31.678 1.00 44.07 o

ATOM 6274 CB ASN F 265 30. .334 65.901 -33.560 1.00 43.88 C

ATOM 6275 CG ASN F 265 30. .430 64.392 -33.709 1.00 45.38 C

ATOM 6276 ODl ASN F 265 31. .428 63.776 -33.337 1.00 43.80 o

ATOM 6277 ND2 ASN F 265 29. .392 63.792 -34.277 1.00 46.59 N

ATOM 6278 N ALA F 266 31. .832 68.595 -32.753 1.00 45.27 N

ATOM 6279 CA ALA F 266 31. .835 70.052 -32.792 1.00 46.52 C

ATOM 6280 C ALA F 266 32. .421 70.556 -34.111 1.00 47.37 C

ATOM 6281 o ALA F 266 33. .250 69.883 -34.732 1.00 47.43 o

ATOM 6282 CB ALA F 266 32. .623 70.610 -31.609 1.00 45.85 C

ATOM 6283 N SER F 267 31. .968 71.734 -34.532 1.00 49.00 N

ATOM 6284 CA sεR F 267 32. ,423 72.370 -35.771 1.00 51.19 C

ATOM 6285 C sεR F 267 32. ,706 73.849 -35.469 1.00 52.95 C

ATOM 6286 o sεR F 267 31. ,914 74.499 -34.782 1.00 53.04 o

ATOM 6287 CB SER F 267 31. ,340 72.264 -36.853 1.00 50.75 C

ATOM 6288 N THR F 268 33. ,844 74.373 -35.941 1.00 55.40 N

ATOM 6289 CA THR F 268 34. .232 75.777 -35.692 1.00 58.15 C

ATOM 6290 C THR F 268 34. .768 76.485 -36.953 1.00 59.75 C

ATOM 6291 o THR F 268 34. .357 76.170 -38.069 1.00 60.60 o

ATOM 6292 CB THR F 268 35. .320 75.880 -34.580 1.00 58.09 C

ATOM 6293 OG1 THR F 268 34. .939 75.080 -33.455 1.00 59.93 o

ATOM 6294 CG2 THR F 268 35. .477 77.321 -34.105 1.00 58.09 C

ATOM 6295 N VAL F 269 35, .698 77.424 -36.775 1.00 61.40 N

ATOM 6296 CA VAL F 269 36. .251 78.165 -37.901 1.00 62.82 C

ATOM 6297 C VAL F 269 37, ,752 78.435 -37.833 1.00 64.22 C

ATOM 6298 o VAL F 269 38. ,540 77.810 -38.553 1.00 64.66 o

ATOM 6299 CB VAL F 269 35, ,531 79.508 -38.057 1.00 62.42 C

ATOM 6300 N VAL F 270 38. ,153 79.376 -36.985 1.00 65.60 N

ATOM 6301 CA VAL F 270 39. ,572 79.711 -36.876 1.00 66.74 C

ATOM 6302 C VAL F 270 39. .911 80.441 -35.578 1.00 67.67 C

ATOM 6303 o VAL F 270 41. .053 80.815 -35.342 1.00 67.88 o

ATOM 6304 CB VAL F 270 40. .035 80.596 -38.049 1.00 66.63 c

ATOM 6305 N GLY F 271 38. .909 80.640 -34.738 1.00 68.56 N

ATOM 6306 CA GLY F 271 39. .123 81.314 -33.470 1.00 69.14 C

ATOM 6307 C GLY F 271 38, ,476 80.536 -32.347 1.00 70.00 c

ATOM 6308 o GLY F 271 38, .561 79.312 -32.314 1.00 70.36 o

ATOM 6309 N ASP F 273 36, .760 78.957 -30.970 1.00 53.40 N

ATOM 6310 CA ASP F 273 36, .988 78.210 -29.739 1.00 53.60 C

ATOM 6311 C ASP F 273 35, ,983 77.068 -29.585 1.00 53.06 C

ATOM 6312 o ASP F 273 34, .844 77.157 -30.052 1.00 53.49 o

ATOM 6313 CB ASP F 273 36, .917 79.147 -28.527 1.00 54.74 C

ATOM 6314 CG ASP F 273 38, .227 79.891 -28.287 1.00 56.07 C

ATOM 6315 ODl ASP F 273 38, ,832 80.363 -29.271 1.00 56.61 o

ATOM 6316 OD2 ASP F 273 38, .649 80.014 -27.116 1.00 55.76 o

ATOM 6317 N VAL F 274 36, ,408 75.991 -28.929 1.00 51.73 N

ATOM 6318 CA VAL F 274 35, .535 74.839 -28.740 1.00 50.50 C

ATOM 6319 C VAL F 274 35, .823 74.060 -27.455 1.00 49.86 C

ATOM 6320 o VAL F 274 36, ,870 74.227 -26.824 1.00 49.68 o

ATOM 6321 CB VAL F 274 35, .653 73.865 -29.931 1.00 50.21 C

ATOM 6322 CGI VAL F 274 36, .962 73.093 -29.849 1.00 49.57 C

ATOM 6323 CG2 VAL F 274 34, ,466 72.925 -29.949 1.00 51.04 C

ATOM 6324 N GLU F 275 34, ,880 73.208 -27.070 1.00 49.12 N

ATOM 6325 CA GLU F 275 35, ,046 72.382 -25.888 1.00 48.19 C

ATOM 6326 C GLU F 275 34, .438 71.004 -26.089 1.00 47.10 C

ATOM 6327 o GLU F 275 33, .559 70.808 -26.928 1.00 47.91 o

ATOM 6328 CB GLU F 275 34, .413 73.037 -24.663 1.00 48.81 C

ATOM 6329 CG GLU F 275 32, ,915 73.193 -24.749 1.00 49.77 C

ATOM 6330 CD GLU F 275 32, ,298 73.481 -23.397 1.00 50.13 C TOM 6331 OEl GLU F 275 32, ,974 74.114 -22.553 1.00 50.91 o

ATOM 6332 OE2 GLU F 275 31, ,136 73.083 -23.185 1.00 50.57 o

ATOM 6333 N PHε F 276 34. ,934 70.050 -25.312 1.00 45.40 N TabU 3

ATOM 6334 CA PHE F 276 34. .458 68. .680 -25.342 1.00 42. .98 c

ATOM 6335 C PHE F 276 34. .182 68. .306 -23.899 1.00 41. .88 c

ATOM 6336 0 PHE F 276 35, .051 68. .445 -23.042 1.00 40. .61 0

ATOM 6337 CB PHE F 276 35, .529 67. ,759 -25.918 1.00 44. ,18 c

ATOM 6338 CG PHE F 276 35, .672 67. .858 -27.405 1.00 45. ,07 c

ATOM 6339 CDl PHE F 276 34, .645 67. .426 -28.242 1.00 45. .08 c

ATOM 6340 CD2 PHE F 276 36, .838 68. .367 -27.972 1.00 45. .06 c

ATOM 6341 CEl PHE F 276 34, .776 67. ,496 -29.625 1.00 46. .84 c

ATOM 6342 cε2 PHE F 276 36, .985 68. .443 -29.352 1.00 46, .77 c

ATOM 6343 CZ PHE F 276 35, .950 68, .006 -30.187 1.00 46. ,46 c

ATOM 6344 N VAL F 277 32, .969 67, .842 -23.630 1.00 40, .76 N

ATOM 6345. CA VAL F 277 32, ,597 67. .471 -22.278 1.00 40. .08 c

ATOM 6346 C VAL F 277 32, ,449 65, .969 -22.130 1.00 39. .86 c

ATOM 6347 0 VAL F 277 32, .090 65. .262 -23.075 1.00 40, .39 o

ATOM 6348 CB VAL F 277 31, ,283 68. .161 -21.857 1.00 39, .97 c

ATOM 6349 CGI VAL F 277 30, .900 67. .749 -20.444 1.00 40. .02 c

ATOM 6350 CG2 VAL F 277 31. .451 69, .675 -21.935 1.00 40, .07 c

ATOM 6351 N CYS F 278 32. .735 65, .483 -20.932 1.00 38, ,84 N

ATOM 6352 CA CYS F 278 32. ,625 64, .068 -20.649 1.00 38, .38 C

ATOM 6353 C CYS F 278 32. .048 63, .891 -19.253 1.00 37, .50 c

ATOM 6354 0 CYS F 278 32, ,347 64. ,685 -18.361 1.00 37, ,83 o

ATOM 6355 CB CYS F 278 33, ,999 63. ,410 -20.730 1.00 39, ,41 c

ATOM 6356 SG CYS F 278 33, .903 61, ,622 -20.662 1.00 42, .56 s

ATOM 6357 N LYS F 279 31, ,217 62, ,865 -19.068 1.00 35, .92 N

ATOM 6358 CA LYS F 279 30, .609 62, .579 -17.764 1.00 34, .91 C

ATOM 6359 C LYS F 279 30, .873 61, .137 -17.332 1.00 33, ,60 C

ATOM 6360 0 LYS F 279 30, .325 60, .190 -17.921 1.00 32, .70 o

ATOM 6361 CB LYS F 279 29. .094 62, .816 -17.798 1.00 35, .37 c

ATOM 6362 CG LYS F 279 28. ,663 64, ,219 -17.399 1.00 38, .47 c

ATOM 6363 CD LYS F 279 29. .108 64, .582 -15.965 1.00 37. .93 c

ATOM 6364 CE LYS F 279 28. .428 63. ,709 -14.913 1.00 38. .82 c

ATOM 6365 NZ LYS F 279 28, ,779 64. .089 -13.513 1.00 37, ,70 N

ATOM 6366 N VAL F 280 31. ,679 60, ,977 -16.281 1.00 31. .94 N

ATOM 6367 CA VAL F 280 32. ,053 59. .653 -15.778 1.00 29. .99 c

ATOM 6368 C VAL F 280 31, ,469 59. ,231 -14.432 1.00 30. .83 C

ATOM 6369 0 VAL F 280 31, ,258 60, .050 -13.534 1.00 30. .77 o

ATOM 6370 CB VAL F 280 33. ,600 59. .531 -15.683 1.00 29. ,69 C

ATOM 6371 CGI VAL F 280 33. ,992 58. ,184 -15.095 1.00 29. .19 C

ATOM 6372 CG2 VAL F 280 34. ,231 59. ,738 -17.073 1.00 28, .52 C

ATOM 6373 N TYR F 281 31. ,213 57, .931 -14.310 1.00 31. .35 N

ATOM 6374 CA TYR F 281 30, ,701 57. .320 -13.082 1.00 32. .39 C

ATOM 6375 C TYR F 281 31, ,546 56. .084 -12.767 1.00 30. .82 C

ATOM 6376 0 TYR F 281 31, .819 55. .279 -13.652 1.00 31, .49 o

ATOM 6377 CB TYR F 281 29, ,246 56. .882 -13.239 1.00 35, .65 C

ATOM 6378 CG TYR F 281 28, .314 57. .977 -13.697 1.00 39, .56 C

ATOM 6379 CDl TYR F 281 28, ,202 58. ,313 -15.054 1.00 41. .11 C

ATOM 6380 CD2 TYR F 281 27. ,532 58, ,672 -12.779 1.00 41. .01 C

ATOM 6381 CEl TYR F 281 27, ,330 59. .311 -15.479 1.00 42. .28 C

ATOM 6382 CE2 TYR F 281 26, ,658 59, .675 -13.195 1.00 43. .31 C

ATOM 6383 CZ TYR F 281 26, ,560 59, .986 -14.546 1.00 43. .29 c

ATOM 6384 OH TYR F 281 25, ,675 60, .962 -14.951 1.00 45. .14 o

ATOM 6385 N SER F 282 31, ,958 55, .935 -11.516 1.00 29, .47 N

ATOM 6386 CA SER F 282 32, .762 54. .789 -11.105 1.00 28, .89 C

ATOM 6387 C SER F 282 32, .877 54. ,700 -9.579 1.00 28. .68 C

ATOM 6388 o SER F 282 32. .899 55. ,722 -8.897 1.00 28. .67 o

ATOM 6389 CB SER F 282 34. .158 54, .890 -11.734 1.00 28. .94 C

ATOM 6390 OG SER F 282 35, .021 53. .879 -11.237 1.00 28. .16 o

ATOM 6391 N ASP F 283 32, .940 53. .478 -9.050 1.00 28. .16 N

ATOM 6392 CA ASP F 283 33, .070 53, ,258 -7.605 1.00 27, .16 C

ATOM 6393 C ASP F 283 34, ,568 53, .311 -7.323 1.00 27, .79 C

ATOM 6394 o ASP F 283 35, ,035 54. .178 -6.589 1.00 27, .96 o

ATOM 6395 CB ASP F 283 32, .502 51, .890 -7.229 1.00 26, .32 C

ATOM 6396 CG ASP F 283 32, ,484 51. .639 -5.723 1.00 25. .14 C

ATOM 6397 ODl ASP F 283 31, ,759 50. .709 -5.315 1.00 25. .10 o

ATOM 6398 OD2 ASP F 283 33. .175 52. .338 -4.947 1.00 22. .71 o

ATOM 6399 N ALA F 284 35. .310 52. ,376 -7.918 1.00 27. .44 N

^r- ^ ^ Φ ^ m ln t~ Φιn ^ Φr- I~ ^ ^ tD oooo ιI\ d o^ oo ^ ^ ^ »dι^,l ι^vlfl ln ^ lIl d n v ln Φ "l' n (1 M d N ^l d N (O CO O (M(S

CM C\I CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rM CM C ro CM ro r CM CM C rOCM CM < CM <0 ( c (^ rO oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

^ (Mιn oo^<M_oo\^^σl(^ι σ^ (Jα)noo^ ιιn(»)rι^oιn<»O <I^fnc^ι<! lnoιn )^com(ll(MlnMιn<JC^^DΦOOΛH O N 03(M ιln(Λ( Hoι>_l^d ^HI^ONΦ^Od0^ι_ood(JlO_'«_'ι)l 030_ιx>nal' (ιJΦΦΦ Hd^■_lNr■oι!lO"l^,d(^0( O ιlO(^Hl'toιΛ v^ln^t^coH_'»ι^^^N HιnΦ^ ι»l HlnwH ι^ι^ι3loo ^) O ^cιl(Mcno)Hl)OΦ vda)d( o^l">^ιo<!lO(l(Mι »c^ιm^O(^,)

> ∞m(o ^ m σ>o ^ ^ Φ ι ^ θ Nd (M H o π '» ιθ "> « ιn ι») ιii 'j ιn r- ^ Φ in ^ ιn α) αi d d o o o d θ (») 'j <ι^| ι^,) !M i») θN '* N <ι^, ι^,) ιt) Φ ∞ Φ i I I l l I I H I i i i I H H H H H H H H H H H H H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM ΓM CM CM CM

I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I oι O o en ro H ιn ιn (^,l

σι o o o o o o o o o o o o o θ H H H H H

[. b l- Iιι b h l- b h h b h h h Eιι I- Iιι lu l- 1- I- h h b b h lu bι b b b b h Iιι h h I- I- I. b b b b rtrtrtrtzzzzzzzzzooooooococ cocococococococoωωιaωωi-iωωzzzzzzzzzojc_a4ciιcι<c_c_ < < O O ϋ D O U lS l30 ft ft l- Λ I- liι ⁽iι 3! ϊ a ϊ a! i a; ϊ ϊ a H μ H H H H H H ϋ U U U U O tJ () [H tι (H tι tι tH Eι t< H t< tι tι Fι tι H H μ H H

H CM H CM H CM H CM H H CM H CM H CM rO CN f CN m ft cQCDQc-iω < CQ CD ^Q m o a a a a CQ CD CD Q CQ CD α ω w ft α jααωωωNNi a, m ϋuouzuϋouuuozzuuouuuzuuouuzuuzzuuouυuuzuuouυuozzuuouuuuguuuuuzuuou li uinι ΦcDi»D

00 ς^, 'J

© εεaaaa

O HooH toioHoHoH

roc ι^< ιι i"- 'y"^ «^ * '^'r i'τ ι ι ι ι ιnι ι ι ι ι ι ι ιnι ιnι^,ι "*i' ^,'rι "^^ι ι ' ( ^{, ,}r (oco{o

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

I H H H H • HHHHHHHHH HHHHHHHH

_n< ! α)dmΦσιΦNl «^J^<ι^lt(ιoodO ^^^(IlH ιιno^ι«) Od 1»HON ιIlOoα! N^eo lnNd0 p^d"»d^^ω^< d-)^H β^n«HrlOl»»^•^oιo o ιl)OH»»ι»4^ιo»»NOιιnoN»ιnoιHloι^,ιι^,)rloιrloβ ιeΛOll)»4ιnpιιnβ»noHBl^,lHn^ι»ιnn ol»βιnnι»ιnd ln«ΦB^fflΦ(n^Nno(^,ιo^ιvnoιn»«0(^,)HN('ιoι ιΛl')«(MΦιn«o^ιnHιnHnd^o ^(βι<1ιnN(η Λ»βlH n

^ 90DΦOOO f]cη"rd(Mι^^(^( ^w(N^HO(Λ O moooσιo^^r_"σ\^n^^,^"^^,f^ ι^ϊ)"^Hι^,cιcMLnΦ^ oιoOlOOfll0 cDa^co^ ιΛo)ιOv

CMCM CM CM CM COro rO CO (O ro co rO CO f rO (0 <O C rO CO CO< ( rg CM CM CM CM C1CM CM CM CM CM CM CM CM CM CM CM C^ I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I nH Mσl coω r~

(Λal iflin ro o v ιθN Φ ιβι'ι d Φ"l^ι (N iπin

H HHHHHC⁽M<CM CM πnfl Plnι^,) σσiι σcnι<<TTIl CCΛΛCσriι HH HH HH HH HH HH HH H H H H H H H

CCMM CCMMCCMM CCMM CCMM h fa b [iι |ιt |iι |ιt b |iι b b b lι< h b lM h [iι b lu [M lu [>ι [u h h h h h h h [iι b b [ lM [>< b h [iι Eiι liι [iι h liι h h lu h ω l ωω ωω Wco tcOo Wc Cco Wc OTc Cco CcOo OTco CcOo Wcό Wco Cco CcOo Pp-- pc-- PpCcj; OS Pή D D D D D D D D W C OT CO CO h-l Hl J J ^pj Hj πJ < < >< >^{H H} r^{H H} < ^H H iH H H H ^H ι ^{H H} >< ω ω i-i ω ω ω _) ω >H H >H >H >H rt rt rt rt rt rt rt ω M ω

I H H rl rl rl J rl rl rl rl hi ai S S S S ei tl El

H CM H H ^• C "M^• H ^• C "M^• HH CCMM

- 15 Q ft ffi U O H N rt CQ ft rt CQ CD Q Q ft CQ rt PQ C CD ft CQ CD α α ft PQ CD Q ω N ft CQ rt υuozcjuooouυzzυυoc zuυoozcjcjouυucj zcjuoυzooouυozoooooucjzc oocjucjozzuυoozυ lOΦ ι»β<O ooι)l H ooo ood ι ι ι ι ι ιΛι ιOιO Φ Φ Φ ΦΦID ΦΦ Φ aεεaaaaaaaaaaaεεεaaaaaaaaaa hooHtoι toιofι toιoEHot<oιoι toι HotoHHooHotι

Table 3

ATOM 6532 C ALA F 315 45.429 63.080 -13.452 1.00 30.61 c

ATOM 6533 o ALA F 315 46.245 62.226 -13.804 1.00 30.29 o

ATOM 6534 CB ALA F 315 43.004 62.623 -13.891 1.00 30.19 c

ATOM 6535 N GLY F 316 45.520 63.750 -12.309 1.00 30.74 N

ATOM 6536 CA GLY F 316 46.598 63.512 -11.374 1.00 32.31 c

ATOM 6537 C GLY F 316 46.654 64.590 -10.309 1.00 34.07 c

ATOM 6538 o GLY F 316 45.778 65.449 -10.234 1.00 33.07 o

ATOM 6539 N VAL F 317 47.686 64.535 -9.479 1.00 35.99 N

ATOM 6540 CA VAL F 317 47.876 65.509 -8.412 1.00 38.96 C

ATOM 6541 C VAL F 317 47.938 66.947 -8.941 1.00 39.46 C

ATOM 6542 o VAL F 317 47.459 67.868 -8.291 1.00 39.05 o

ATOM 6543 CB VAL F 317 49.170 65.196 -7.629 1.00 39.98 C

ATOM 6544 CGI VAL F 317 49.543 66.364 -6.738 1.00 42.38 c

ATOM 6545 CG2 VAL F 317 48.962 63.936 -6.776 1.00 40.44 c

ATOM 6546 N ASN F 318 48.519 67.127 -10.124 1.00 41.29 N

ATOM 6547 CA ASN F 318 48.641 68.457 -10.716 1.00 43.00 C

ATOM 6548 C ASN F 318 47.511 68.828 -11.665 1.00 43.30 C

ATOM 6549 o ASN F 318 47.473 69.939 -12.184 1.00 43.85 o

ATOM 6550 CB ASN F 318 49.977 68.598 -11.442 1.00 44.26 C

ATOM 6551 CG ASN F 318 51.132 68.755 -10.482 1.00 45.68 C

ATOM 6552 ODl ASN F 318 51.083 69.578 -9.571 1.00 46.62 o

ATOM 6553 ND2 ASN F 318 52.182 67.968 -10.680 1.00 47.19 N

ATOM 6554 N THR F 319 46.603 67.891 -11.901 1.00 42.99 N

ATOM 6555 CA THR F 319 45.457 68.141 -12.765 1.00 42.33 C

ATOM 6556 C THR F 319 44.283 67.370 -12.167 1.00 41.92 C

ATOM 6557 o THR F 319 43.915 66.291 -12.637 1.00 41.66 o

ATOM 6558 CB THR F 319 45.709 67.671 -14.218 1.00 42.29 C

ATOM 6559 OG1 THR F 319 46.962 68.179 -14.689 1.00 42.83 o

ATOM 6560 CG2 THR F 319 44.618 68.191 -15.126 1.00 41.88 c

ATOM 6561 N THR F 320 43.721 67.951 -11.114 1.00 41.14 N

ATOM 6562 CA THR F 320 42.604 67.406 -10.347 1.00 40.93 C

ATOM 6563 C THR F 320 41.342 67.029 -11.133 1.00 40.66 C

ATOM 6564 0 THR F 320 41.114 67.531 -12.234 1.00 40.21 o

ATOM 6565 CB THR F 320 42.246 68.416 -9.215 1.00 40.83 C

ATOM 6566 OG1 THR F 320 43.268 68.369 -8.217 1.00 41.48 o

ATOM 6567 CG2 THR F 320 40.905 68.104 -8.572 1.00 41.34 c

ATOM 6568 N ASP F 321 40.530 66.141 -10.550 1.00 39.85 N

ATOM 6569 CA ASP F 321 39.279 65.691 -11.164 1.00 40.39 C

ATOM 6570 C ASP F 321 38.250 66.816 -11.303 1.00 40.53 C

ATOM 6571 o ASP F 321 37.332 66.725 -12.117 1.00 40.60 o

ATOM 6572 CB ASP F 321 38.623 64.566 -10.341 1.00 40.53 C

ATOM 6573 CG ASP F 321 39.375 63.252 -10.417 1.00 40.72 C

ATOM 6574 ODl ASP F 321 40.091 63.029 -11.411 1.00 40.02 o

ATOM 6575 OD2 ASP F 321 39.230 62.434 -9.483 1.00 40.69 o

ATOM 6576 N LYS F 322 38.389 67.863 -10.497 1.00 40.77 N

ATOM 6577 CA LYS F 322 37.443 68.979 -10.526 1.00 40.58 C

ATOM 6578 C LYS F 322 37.221 69.549 -11.922 1.00 40.18 C

ATOM 6579 o LYS F 322 36.099 69.875 -12.291 1.00 40.21 o

ATOM 6580 CB LYS F 322 37.914 70.098 -9.589 1.00 40.95 c

ATOM 6581 N GLU F 323 38.288 69.653 -12.704 1.00 40.02 N

ATOM 6582 CA GLU F 323 38.184 70.221 -14.046 1.00 40.16 C

ATOM 6583 C GLU F 323 38.671 69.305 -15.174 1.00 40.12 C

ATOM 6584 o GLU F 323 38.862 69.755 -16.308 1.00 39.87 o

ATOM 6585 CB GLU F 323 38.971 71.537 -14.096 1.00 40.79 C

ATOM 6586 N ILE F 324 38.856 68.024 -14.872 1.00 39.58 N

ATOM 6587 CA ILE F 324 39.353 67.066 -15.857 1.00 38.68 C

ATOM 6588 C ILE F 324 38.302 66.638 -16.897 1.00 37.55 c

ATOM 6589 o ILE F 324 38.649 66.236 -18.002 1.00 36.91 o

ATOM 6590 CB ILE F 324 39.925 65.801 -15.118 1.00 39.46 c

ATOM 6591 CGI ILE F 324 41.225 65.329 -15.772 1.00 40.20 c

ATOM 6592 CG2 ILE F 324 38.890 64.689 -15.079 1.00 39.11 c

ATOM 6593 CDl ILE F 324 41.097 64.896 -17.187 1.00 40.48 c

ATOM 6594 N GLU F 325 37.024 66.742 -16.560 1.00 37.08 N

ATOM 6595 CA GLU F 325 35.976 66.321 -17.489 1.00 38.65 C

ATOM 6596 C GLU F 325 35.615 67.265 -18.641 1.00 39.40 C

ATOM 6597 o GLU F 325 34.725 66.964 -19.440 1.00 39.05 o

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

n ιn w ιn co ιΛ ri N ι n <M Φ <n « ιn Φ o m ^ ιn ^ Λ H o ι» oo ^ H ^ N N m <M H in n ιn ^ "r H ^ ^ o ιn (M in N i^,) inH r- θ N θ o n ^ i3i H r- Φ Φ n d fl ι ln a! π σι H "r (M "I' H ^ >f l!l lo ( H (^ι (M n a) d HN ιn d d ιxι c^ι n ιo t n ι^,l H Φo * N <IlιIl w o d ιJ\ ιn ^^' d ιΛ (!ιιo ^ <>ιo ^ n o ^ a) H ^ o o o N ^ ιD ^ ι» n ιn Φ (I) ιn "f l ^ι^ι '» fl ι βι o ^ o ^ι ι») <Λ Φ «ι^ι ^ <l ln H (n -l ι«) H ^ "» m 'l' ln ^i ιn n 'l^| Λ ι^,1 (D o ω H Φ «ι' H (M ^ Φ O H H ιn ^ ιn ω ol o ιΛ Ol o ω H !M n "» n v n ιn π n fl "f ιη φ ^ ^ <» ω ^ oo σ^ ol ^ o H lM l H l n "» ln (η ιn Φ ^ ω m m o oo ^ Φ Φ ιn '» ι '» f) <^,l

H H H H H H H CM H H CM H CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM C CM CM Cj ro rO r CO r r CO ro rn iO rO rO C rO fO fO CO fO f l CO C I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

H ' ln (n Λ ιn ιn ^ ' ln p _ <^ι ι^ o o H o o^ m H H o ω co ^ tM n (η (^ ι» "f « ln ιnn Φ _ r^■ m σl o al _ o ι-^■ Φ Φ ^ ln ln ιl <» (n ιn ^ ι») H O ^^ (M o o Λ H d o ol o H (M φ φ φ φ r^ ι^ r^ ^ Φ i^ t^ Φ Φ Φ r^ r. t^ t^ r* ι^ r^ t^ r. r* ι^ r* ι^ t^ t^ C' [^ r. r ∞ r^ r. r* p^ r" r" r* (^ M^ r- r^ r^ r* ι^ r^ r^ ι^ r" i^ r^ . [^ ro

ιnlll lflιn ln ι^,)nc)n⁽ <f W "r«mlnιflmln

CM CM CM CM CM CM CM CM CM CM CM CM ro ( (θ c ( ro c ro c c ( c ta ta u ta ta h ta h h i_j h h h fø ta ta rju Ui fa fa

D O D D D HH HH HH HH J J iJ D D D D D D D D ttl rt PU PS tf W W W W W CD CD CD CD CD Z Z Z Z Z r_ r H rl r « _ P- , P, W (- C-i ω ω D D D D D (_ (_ θ4 Q PH θ , ^ ^ ^ ft < ft ft rt rt rt ta ω cd i_ _ ω i-i ω rH rH >< >4 H H^ ι-i Hi Hi H3 pή i pc; ps oώ co o o o w rt rt rt rt rt 3 s a s x B B X X X HJ r3 ^ H} ,^ w o Q o t CD CD CD CD CD > > > > > > > _l_^| _>-l -l H^j _l ^j H -l H3 E^H E^H E^H H ^H H H H H H rt rt rt rt rt rt rt rt rt rt > > > > > E^H E^H E^H E^H E^H CM pH f-ι C-ι PM CD CD CD CJ⁾ _l rt rt rt rt rt rt

H CM H CM H CM

C^Q CD ^Q W ω rt CQ CD CD rt CQ CD ^{Q Q} rt CQ ft CQ rt CQ oυcjoozuoouυυzuuooυυuzυooozooouzυuoυ < C^Q rt C^Q rt CQ rt CQ rt CQ rt CQ CD c cjocjzc cjoc zυυoozcjuouzuuoozuoooo tD Ol O H < n "l' ln m σi (S θ θ θ θ θ θ θ io

00 ( l Φ Φ Φ Φ Φ Φ Φ Φ rH lO lø lO CO lO lO CO VO VO lO

© εεεεεεεεaaaaasaaaaaεgεaaεεaaεaaas o oooooooooooooooσoooooooooooooooooooooooooooooooooooooooooooooooooo it

_OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO _{O O O}OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

ln ιn _ o d oo1 o >n <I< N « n ι Hl' (MOO d M' d d ιlco o Ol oomo o o

^plι^»ιn(ηιnn w <f " "f ιnιnlnιnΦ Φ c o ro r c ro c ro coc c i c coio i ro c c coroi r c c r ro o co r^

C_ [_ CiH C-l I-l ^{-l C-l ^ 4 (-4 E_ l-t _l b Pμ [-l 4 l-l C l-l tM 4 l-l 4 [-l C-l [-4 4 b C-^

C Pu rt rt. rt. rt rt >H H :>H H D D D D D _> D D D tZAeCaicccύcύcύcύcύeicύpscύβi&fύβiciiiΛwuiuimoi D D ro o D D D D rt

X X X X X X X X X X X X X X X X X X X X X X X X X 25 Z Z Z ω ω c_ c_ _ „ rt rt rt rt rt rt rt D CD CD CD CD CD CD CD CD CD CD CD CJ) EH EH EH EH EH EH EH EH EH EH EH EH EH EH H EH EH EH EH O CJ O O U U rt rt rt c) CD CJ rt rt rt rt

H CM

Q Q rt PQ rt < cn CD α ω cd rt DQ Q Q W W N X UOOOOOOZOUOOUUUOOOO rt C^Q D O rt PQ CJ⁾ rt PQ CD α α rt CQ rt <

O O Z - ϋ OUZOUOZO zuc ooouzuooυcozuoooυuυzuoouzuuozooo lIι N

00 p* rH Φ

© εoaoaooaaooaoaoaaooaaoaoaoaoaoaoaooaoaaoεooεεoεooεoεoaaooaoEsoεoaoεoεoεoεosoεoaooaoaεooεoεoεεoεooεoεεoεooεoεεooεεooaoaaooaaooaεooaεo o

TάblFS

ATOM 6730 CB ASN F 346 38.722 51.866 -12.293 1.00 26.34 c

ATOM 6731 CG ASN F 346 37.637 50.911 -12.800 1.00 26.84 c

ATOM 6732 ODl ASN F 346 37.935 49.865 -13.375 1.00 24.75 o

ATOM 6733 ND2 ASN F 346 36.368 51.269 -12.563 1.00 24.95 N

ATOM 6734 N SER F 347 40.879 49.866 -11.931 1.00 29.98 N

ATOM 6735 CA SER F 347 41.499 48.539 -11.837 1.00 32.45 C

ATOM 6736 C SER F 347 40.738 47.443 -12.569 1.00 33.80 C

ATOM 6737 o SER F 347 41.347 46.475 -13.005 1.00 34.43 o

ATOM 6738 CB SER F 347 41.695 48.102 -10.375 1.00 34.30 C

ATOM 6739 OG SER F 347 40.460 47.838 -9.725 1.00 37.06 o

ATOM 6740 N ILE F 348 39.419 47.582 -12.712 1.00 34.07 N

ATOM 6741 CA ILE F 348 38.638 46.556 -13.415 1.00 34.74 C

ATOM 6742 C ILE F 348 38.746 46.629 -14.942 1.00 34.67 c

ATOM 6743 o ILE F 348 38.858 45.603 -15.606 1.00 34.73 o

ATOM 6744 CB ILE F 348 37.117 46.608 -13.080 1.00 35.89 c

ATOM 6745 CGI ILE F 348 36.872 46.336 -11.594 1.00 36.06 c

ATOM 6746 CG2 ILE F 348 36.370 45.572 -13.931 1.00 36.09 c

ATOM 6747 CDl ILE F 348 37.101 47.530 -10.702 1.00 38.46 c

ATOM 6748 N GLY F 349 38.690 47.834 -15.502 1.00 34.21 N

ATOM 6749 CA GLY F 349 38.766 47.970 -16.946 1.00 33.77 C

ATOM 6750 C GLY F 349 38.755 49.395 -17.477 1.00 33.75 C

ATOM 6751 o GLY F 349 38.798 50.361 -16.711 1.00 33.67 o

ATOM 6752 N ILε F 350 38.670 49.511 -18.801 1.00 33.27 N

ATOM 6753 CA ILε F 350 38.683 50.794 -19.498 1.00 33.45 C

ATOM 6754 C ILε F 350 37.449 51.057 -20.370 1.00 33.70 C

ATOM 6755 o ILε F 350 36.901 50.142 -20.983 1.00 33.76 o

ATOM 6756 CB IL F 350 39.926 50.894 -20.411 1.00 33.49 C

ATOM 6757 CGI ILE F 350 41.198 50.775 -19.567 1.00 34.27 C

ATOM 6758 CG2 ILE F 350 39.907 52.199 -21.187 1.00 34.40 C

ATOM 6759 CDl ILE F 350 42.482 50.712 -20.381 1.00 36.09 C

ATOM 6760 N SER F 351 37.029 52.321 -20.418 1.00 32.59 N

ATOM 6761 CA SER F 351 35.903 52.764 -21.240 1.00 32.30 C

ATOM 6762 C SER F 351 36.291 54.075 -21.921 1.00 32.43 C

ATOM 6763 o sεR F 351 37.085 54.848 -21.378 1.00 31.37 o

ATOM 6764 CB sεR F 351 34.655 53.006 -20.394 1.00 32.47 C

ATOM 6765 OG sεR F 351 34.115 51.793 -19.920 1.00 34.26 o

ATOM 6766 N PHE F 352 35.735 54.329 -23.104 1.00 32.25 N

ATOM 6767 CA PHE F 352 36.039 55.561 -23.828 1.00 33.49 C

ATOM 6768 C PHE F 352 34.990 55.930 -24.873 1.00 33.58 C

ATOM 6769 o PHE F 352 34.419 55.057 -25.537 1.00 33.77 o

ATOM 6770 CB PHE F 352 37.414 55.455 -24.504 1.00 34.61 C

ATOM 6771 CG PHE F 352 37.525 54.317 -25.491 1.00 36.55 C

ATOM 6772 CDl PHE F 352 37.059 54.453 -26.797 1.00 38.08 C

ATOM 6773 CD2 PHE F 352 38.093 53.109 -25.109 1.00 37.89 C

ATOM 6774 CEl PHE F 352 37.161 53.396 -27.711 1.00 39.20 c

ATOM 6775 CE2 PHE F 352 38.201 52.047 -26.010 1.00 38.88 c

ATOM 6776 CZ PHE F 352 37.734 52.191 -27.313 1.00 39.32 c

ATOM 6777 N HIS F 353 34.737 57.227 -25.011 1.00 33.60 N

ATOM 6778 CA HIS F 353 33.787 57.731 -26.004 1.00 34.44 C

ATOM 6779 C HIS F 353 34.539 58.773 -26.831 1.00 35.35 c

ATOM 6780 o HIS F 353 35.359 59.528 -26.295 1.00 35.17 o

ATOM 6781 CB HIS F 353 32.559 58.386 -25.351 1.00 34.07 c

ATOM 6782 CG HIS F 353 31.579 57.416 -24.759 1.00 34.66 c

ATOM 6783 ND1 HIS F 353 30.424 57.821 -24.121 1.00 33.93 N

ATOM 6784 CD2 HIS F 353 31.571 56.059 -24.713 1.00 34.45 C

ATOM 6785 CEl HIS F 353 29.750 56.762 -23.711 1.00 32.42 C

ATOM 6786 NE2 HIS F 353 30.424 55.682 -24.058 1.00 33.28 N

ATOM 6787 N SER F 354 34.261 58.806 -28.133 1.00 35.90 N

ATOM 6788 CA SER F 354 34.931 59.739 -29.032 1.00 36.78 C

ATOM 6789 C SER F 354 33.997 60.684 -29.777 1.00 37.44 C

ATOM 6790 o sεR F 354 32.812 60.406 -29.968 1.00 36.86 o

ATOM 6791 CB sεR F 354 35.770 58.963 -30.045 1.00 36.92 C

ATOM 6792 OG SER F 354 36.682 58.111 -29.379 1.00 38.08 o

ATOM 6793 N ALA F 355 34.551 61.816 -30.187 1.00 38.59 N

ATOM 6794 CA ALA F 355 33.801 62.813 -30.938 1.00 40.11 C

ATOM 6795 C ALA F 355 34.737 63.388 -31.994 1.00 41.10 C O CJ O U Z O O O O O O Z O Z Z Z U CJ O CJ Z O U O U U CJ Z U U O U U U U U CJ O O

co o ^, o σι ιn o cD ro θ H in cθ H CM r~ c_ oo cM n H oo m cD σι H σι r- H CM CM Cθ H cθ ιn co o _⁾ o c co M co o oo < ι r~ 'r 'r r- ι θ "* C r oo r-- σι ro o o cD p- 'r ιΛ r- θ 'iι oo cD ιn H CM H Co ιn ιn σι σι σι αι c» CD Co co co cΛ o cτι o o cΛ ιn «" < (θ CM f c f CM CM ro ro cM ro ( < cθ "i) ιn ιn cD ιn iD co c ro ro ro c f ro r < c "* cθ "^ 'r c (θ < ro ro c c ro ro co r ro r c (θ ro ( (θ r ro ro c ro r

OOOOOOOOOOOOOOOOOOOOOOOOO ooooooooooooooooooooooooooooσooooooooooo OOOOOOOOOOOOOOOOOOOOOOOOO oooooooooooooooooooooooooooooooooooooooo

H H H H H , o oo o iD tΛ H n cM H in cD CM θ r~ co o m f oo r~ f CD σι cΛ CM VD OO Oa oO O H n σ^ CO H OO T O t^- CM H O ' σ^ CD CM in o r- H CO OO H CD OO in in in fO H m CD H CΛ H θ σι m ιo σι M co r~ ιn o ιn ι H t~ r~ M cn m co o n H < σι cM o σι H in <τ> c ι~ ιn co o cM '»' <τι o co oo H CD CM f r- σι o oo H c r~ ιo o -ι^, H σi H [-~ oo r-- cD

ITl O lTϊ O O r- l' fO 'ϊ' CΛ VO CD lO σ'l lO I^ OO C CM lO CO OO CM H i co o co r- o co cM σi H o σi σi m H H io σi r^ i' in o ro o co ro o r- H H Oo in cM O CM r- co σi σi io r-

H θ CM i' i' (θ ιn τ 'j" in vD r co ι^, ro ιo r~ ι~- c~ oo co oo θ H oo M cM rθ ' H H σι σi H σι σι σ σι σι oo m oo r- r- σι co ιn i' i ι^, ι co ' <^yι c M in ιn ι 'iι ι i" i ιn co ro n n n i n n n to r f r r ro n m ro co ro ro co fo lo co co io cD co cD t in cD m i m m i in m in m in m m in in m in in in in m m in in m i iO io m in in

I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I co r~ ιn oo ιn o oo n oo o ro oo co cM r- cΛ cM io α) "- σ> σi f σι co CD CD H CM CO O ro σi o m 'J' O CD CO CM rO O CM m cD CM CO r- CM H I— O H C σ> H f CM 1^, CO r~ σι 1' H CM cM H tn f in vD o cD o ι~ cM θ θ oo o ιn co m σι σι ιn cvi n < ro σι H (θ r~ r~ H r σι t~ r r- ιn c r- o o ιn r n co H θ ι r^ o c H H θ c D H CN θ co r~ co cΛ ιn r- Λ θ iθ H r~ H r- CM m H r- cM m o t~ M θ ιn m σι ιι oo o c iO H CM O cD CD m in i— r~ ' ^, p- f r-- D c <Λ m m c r- <Λ io co <Λ ιn H o o co < ιn o H CM in H

CM

( <O 1ι 1ι CD CD "- CD 000000 C0 O O H CΛ CΛ H CM σi H CM (O CM C0 m ιO ^, rθ lθ n CM CM C H H O CΛ OO Oθ r- H H H O O H H C OO H CM H CΛ OO OO Cfi r- OO C3i r— O 00 CΛ O o φ Φ Φ Φ Φ Φ c- r^ r^ Φ r^ f^ i^ i^ i^ r^ r^ ιΛiΛinιπLniΛΛιfiιήιΛιnΛ"P^"i'"innιntnιπιnιπto<^,")^|ιoιoiΛ"i'"]^,"i^," "r")i")^,fl^,ι/ "j^,"ϊ^,ιo

C0 l' -> O l0 ' n θ CM m ιn ιn oo cM θo r~ oo o oo σι cM CM in ιn co o r- σι oo cD r-- o ιr) ιn r- co H i^, H co iD ιn ιn iD n co r- H oo cM i ⁱ o H in cM r~ ιn <τ> oθ "o^, "- oo ro H r-- co o cM r~ H CM ro σι cM C_ H θ crι CD H θ cΛ oo < σι o

<^ <M H <Tl <Tl 00 m O H C0 H CM 1' H H CM 00 r- O CM r0 "3 H < 1' ιn H in 00 H H H ιn θ 001 00 CM C r0 ιn C0 C0 CΛ lO n ' i i c ' Co co cD σι c_ CD θ H CM H CM ' CM r-- cD r-- oo ιn cD r-- r- co ιo ιn ιn oo σ» σ> o σ> H H CM CM r ro -ι r f f M ro n n m ro n CM CM CM rO rO CO CO C C M CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C CM C f C CO C rO CO

H .

oa it ftm mmm m mm m mm m m fimm m mm mmmm^ immmmmm mmm mmmmmmm m mmm m mmm mm m f m m m m

Table 3

ATOM 6862 N TRP G 156 29.702 46.938 -51.861 1.00 33.53 N

ATOM 6863 CA TRP G 156 30.424 46.757 -50.596 1.00 34.85 C

ATOM 6864 C TRP G 156 31.911 46.557 -50.862 1.00 36.39 C

ATOM 6865 0 TRP G 156 32.288 45.709 -51.664 1.00 36.88 o

ATOM 6866 CB TRP G 156 29.887 45.538 -49.827 1.00 32.98 C

ATOM 6867 CG TRP G 156 28.412 45.584 -49.563 1.00 31.32 C

ATOM 6868 CDl TRP G 156 27.509 44.581 -49.784 1.00 29.97 C

ATOM 6869 CD2 TRP G 156 27.665 46.694 -49.055 1.00 29.82 C

ATOM 6870 NEl TRP G 156 26.245 45.001 -49.450 1.00 29.21 N

ATOM 6871 CE2 TRP G 156 26.310 46.293 -48.999 1.00 29.86 C

ATOM 6872 CE3 TRP G 156 28.007 47.987 -48.643 1.00 29.96 C

ATOM 6873 CZ2 TRP G 156 25.294 47.142 -48.548 1.00 29.44 C

ATOM 6874 CZ3 TRP G 156 26.992 48.840 -48.191 1.00 30.20 C TOM 6875 CH2 TRP G 156 25.653 48.410 -48.149 1.00 30.96 C

ATOM 6876 N THR G 157 32.754 47.329 -50.182 1.00 38.26 N

ATOM 6877 CA THR G 157 34.203 47.226 -50.366 1.00 40.35 C

ATOM 6878 C THR G 157 34.873 46.270 -49.392 1.00 42.46 C

ATOM 6879 o THR G 157 36.078 46.046 -49.484 1.00 43.05 o

ATOM 6880 CB THR G 157 34.930 48.602 -50.213 1.00 39.64 C

ATOM 6881 OG1 THR G 157 34.635 49.174 -48.933 1.00 38.76 o

ATOM 6882 CG2 THR G 157 34.515 49.570 -51.308 1.00 39.60 c

ATOM 6883 N ASN G 158 34.103 45.706 -48.466 1.00 43.84 N

ATOM 6884 CA ASN G 158 34.670 44.792 -47.482 1.00 45.69 C

ATOM 6885 C ASN G 158 33.595 43.928 -46.828 1.00 45.42 C

ATOM 6886 0 ASN G 158 33.163 44.209 -45.716 1.00 45.32 o

ATOM 6887 CB ASN G 158 35.410 45.601 -46.408 1.00 47.44 C

ATOM 6888 CG ASN G 158 36.131 44.719 -45.403 1.00 50.56 C

ATOM 6889 ODl ASN G 158 35.508 43.939 -44.678 1.00 52.48 o

ATOM 6890 ND2 ASN G 158 37.457 44.834 -45.360 1.00 51.45 N

ATOM 6891 N THR G 159 33.178 42.874 -47.520 1.00 46.07 N TOM 6892 CA THR G 159 32.146 41.968 -47.020 1.00 46.62 C

ATOM 6893 C THR G 159 32.564 41.185 -45.781 1.00 46.29 C

ATOM 6894 o THR G 159 31.711 40.716 -45.029 1.00 46.39 o

ATOM 6895 CB THR G 159 31.751 40.953 -48.096 1.00 46.81 C

ATOM 6896 OG1 THR G 159 32.913 40.207 -48.495 1.00 47.00 o

ATOM 6897 CG2 THR G 159 31.172 41.663 -49.297 1.00 46.53 C

ATOM 6898 N GLU G 160 33.871 41.032 -45.579 1.00 46.49 N

ATOM 6899 CA GLU G 160 34.393 40.294 -44.429 1.00 46.06 C

ATOM 6900 C GLU G 160 33.858 40.887 -43.129 1.00 46.02 C TOM 6901 0 GLU G 160 33.367 40.164 -42.264 1.00 45.54 o

ATOM 6902 CB GLU G 160 35.920 40.335 -44.413 1.00 46.21 C

ATOM 6903 N LYS G 161 33.951 42.209 -43.007 1.00 45.89 N

ATOM 6904 CA LYS G 161 33.483 42.926 -41.822 1.00 45.83 C

ATOM 6905 C LYS G 161 31.959 42.991 -41.700 1.00 45.38 C

ATOM 6906 o LYS G 161 31.445 43.581 -40.753 1.00 45.49 o

ATOM 6907 CB LYS G 161 34.026 44.363 -41.819 1.00 46.64 C

ATOM 6908 CG LYS G 161 35.547 44.475 -41.765 1.00 48.45 C

ATOM 6909 CD LYS G 161 35.984 45.937 -41.698 1.00 49.04 C

ATOM 6910 CB LYS G 161 37.496 46.060 -41.529 1.00 50.22 c

ATOM 6911 NZ LYS G 161 37.949 47.487 -41.526 1.00 50.00 N

ATOM 6912 N MET G 162 31.237 42.402 -42.650 1.00 44.59 N

ATOM 6913 CA MET G 162 29.773 42.436 -42.624 1.00 43.97 C

ATOM 6914 C MET G 162 29.138 41.062 -42.425 1.00 43.84 C

ATOM 6915 o MET G 162 27.921 40.954 -42.286 1.00 44.07 o

ATOM 6916 CB MET G 162 29.240 43.050 -43.928 1.00 42.91 C

ATOM 6917 CG MET G 162 29.687 44.487 -44.197 1.00 40.62 C

ATOM 6918 SD MET G 162 29.237 45.043 -45.875 1.00 39.77 s

ATOM 6919 cε MET G 162 27.459 45.242 -45.697 1.00 39.45 C

ATOM 6920 N GLU G 163 29.960 40.018 -42.405 1.00 44.03 N

ATOM 6921 CA GLU G 163 29.468 38.651 -42.247 1.00 43.93 C

ATOM 6922 C GLU G 163 28.762 38.384 -40.915 1.00 42.61 C

ATOM 6923 o GLU G 163 27.810 37.613 -40.870 1.00 42.58 o

ATOM 6924 CB GLU G 163 30.625 37.660 -42.431 1.00 45.99 C

ATOM 6925 CG GLU G 163 31.400 37.853 -43.733 1.00 49.23 C

ATOM 6926 CD GLU G 163 32.552 36.870 -43.893 1.00 51.45 C

ATOM 6927 OEl GLU G 163 33.169 36.510 -42.865 1.00 52.67 o Table 3

ATOM 6928 OE2 GLU G 163 32.853 36.471 -45.045 1.00 52.43 0

ATOM 6929 N LYS G 164 29.234 39.008 -39.837 1.00 41.12 N

ATOM 6930 CA LYS G 164 28.631 38.836 -38.509 1.00 39.70 C

ATOM 6931 C LYS G 164 27.307 39.618 -38.484 00 38.39 C

ATOM 6932 o LYS G 164 27.299 40.830 -38.274 00 38.68 0

ATOM 6933 CB LYS G 164 29.591 39.363 -37.418 00 39.23 c

ATOM 6934 CG LYS G 164 29.140 39.093 -35.962 00 38.82 c

ATOM 6935 CD LYS G 164 30.121 39.706 -34.939 00 38.47 c

ATOM 6936 CE LYS G 164 29.622 39.572 -33.506 00 37.66 c

ATOM 6937 NZ LYS G 164 30.524 40.217 -32.490 00 37.42 N

ATOM 6938 N ARG G 165 26.192 38.924 -38.695 1.00 36.91 N

ATOM 6939 CA ARG G 165 24.884 39.580 -38.738 00 36.31 C

ATOM 6940 C ARG G 165 24.287 39.864 -37.370 00 35.60 c

ATOM 6941 o ARG G 165 23.715 40.934 -37.146 00 34.92 0

ATOM 6942 CB ARG G 165 23.899 38.746 -39.572 00 36.23 c

ATOM 6943 N LEU G 166 24.406 38.903 -36.460 00 35.23 N

ATOM 6944 CA LEU G 166 23.887 39.075 -35.113 00 34.50 C

ATOM 6945 C LEU G 166 24.981 39.588 -34.171 00 34.23 C

ATOM 6946 o LEU G 166 26.028 38.956 -34.004 00 34.46 O

ATOM 6947 CB LEU G 166 23.306 37.757 -34.596 00 34.17 C

ATOM 6948 CG LEU G 166 23.006 37.689 -33.090 00 35.92 c

ATOM 6949 CDl LEU G 166 22.123 38.851 -32.648 00 34.55 c

ATOM 6950 CD2 LEU G 166 22.348 36.362 -32.777 00 35.42 c

ATOM 6951 N HIS G 167 24.733 40.753 -33.582 00 33.90 N

ATOM 6952 CA HIS G 167 25.652 41.369 -32.625 00 34.03 C

ATOM 6953 C HIS G 167 25.037 41.301 -31.238 1.00 34.08 C

ATOM 6954 o HIS G 167 24.132 42.078 -30.919 1.00 34.22 O

ATOM 6955 CB HIS G 167 25.897 42.842 -32.949 1.00 34.75 C

ATOM 6956 CG HIS G 167 26.975 43.069 -33.954 1.00 35.95 C

ATOM 6957 ND1 HIS G 167 26.910 42.576 -35.239 1.00 36.61 N

ATOM 6958 CD2 HIS G 167 28.160 43.715 -33.857 1.00 36.49 C

ATOM 6959 cεi HIS G 167 28.010 42.906 -35.891 1.00 36.40 C

ATOM 6960 N 2 HIS G 167 28.786 43.597 -35.074 .00 37.07 N

ATOM 6961 N ALA G 168 25.505 40.370 -30.418 .00 33.10 N

ATOM 6962 CA ALA G 168 24.996 40.259 -29.061 ,00 32.60 C

ATOM 6963 C ALA G 168 26.108 40.801 -28.175 .00 32.87 C

ATOM 6964 o ALA G 168 27.237 40.302 -28.212 .00 33.14 O

ATOM 6965 CB ALA G 168 24.682 38.809 -28.725 .00 33.23 C

ATOM 6966 N VAL G 169 25.799 41.838 -27.402 1.00 32.15 N

ATOM 6967 CA VAL G 169 26.798 42.454 -26.546 00 33.09 C

ATOM 6968 C VAL G 169 26.284 42.769 -25.156 00 33.02 C

ATOM 6969 o VAL G 169 25.087 42.930 -24.935 00 33.52 O

ATOM 6970 CB VAL G 169 27.341 43.768 -27.167 00 34.37 C

ATOM 6971 CGI VAL G 169 27.788 43.514 -28.609 00 35.12 C

ATOM 6972 CG2 VAL G 169 26.268 44.858 -27.117 00 34.22 C

ATOM 6973 N PRO G 170 27.198 42.859 -24.192 00 32.91 N

ATOM 6974 CA PRO G 170 26.867 43.159 -22.800 00 32.72 C

ATOM 6975 C PRO G 170 26.401 44.612 -22.658 00 34.03 C

ATOM 6976 o PRO G 170 26.931 45.508 -23.333 1.00 33.46 o

ATOM 6977 CB PRO G 170 28.192 42.936 -22.075 1.00 32.27 c

ATOM 6978 CG PRO G 170 28.917 41.954 -22.950 1.00 33.28 c

ATOM 6979 CD PRO G 170 28.616 42.475 -24.323 00 33.23 c

ATOM 6980 N ALA G 171 25.430 44.840 -21.776 00 33.75 N

ATOM 6981 CA ALA G 171 24.909 46.177 -21.524 00 34.33 C

ATOM 6982 C ALA G 171 26.050 47.100 -21.120 00 34.09 C

ATOM 6983 o ALA G 171 27.022 46.646 -20.512 00 33.95 O

ATOM 6984 CB ALA G 171 23.859 46.130 -20.408 00 34.12 C

ATOM 6985 N ALA G 172 25.931 48.380 -21.487 00 33.12 N

ATOM 6986 CA ALA G 172 26.914 49.411 -21.157 00 33.26 C

ATOM 6987 C ALA G 172 28.082 49.537 -22.136 00 33.48 C

ATOM 6988 o ALA G 172 28.915 50.442 -22.014 1.00 34.33 O

ATOM 6989 CB ALA G 172 27.446 49.198 -19.729 1.00 32.38 C

ATOM 6990 N ASN G 173 28.155 48.634 -23.101 1.00 33.22 N

ATOM 6991 CA ASN G 173 29.225 48.679 -24.091 1.00 33.37 C

ATOM 6992 C ASN G 173 28.840 49.566 -25.272 1.00 32.71 C

ATOM 6993 o ASN G 173 27.684 49.962 -25.423 1.00 32.68 O Table 3

ATOM 6994 CB ASN G 173 29.524 47.269 -24.629 1.00 34. ,62 c

ATOM 6995 CG ASN G 173 30.296 46.404 -23.640 1.00 34. ,28 C

ATOM 6996 ODl ASN G 173 30.170 46.554 -22.433 1.00 37. ,26 0

ATOM 6997 ND2 ASN G 173 31.080 45.481 -24.158 1.00 34, ,66 N

ATOM 6998 N THR G 174 29.830 49.873 -26.102 1.00 31. .59 N

ATOM 6999 CA THR G 174 29.627 50.659 -27.311 1.00 30. .98 C

ATOM 7000 C THR G 174 29.460 49.669 -28.472 1.00 30, .95 C

ATOM 7001 o THR G 174 30.179 48.669 -28.544 1.00 30, .81 o

ATOM 7002 CB THR G 174 30.860 51.529 -27.626 1.00 30. ,59 C

ATOM 7003 OG1 THR G 174 30.907 52.642 -26.730 1.00 31, .56 o

ATOM 7004 CG2 THR G 174 30.812 52.029 -29.074 1.00 29, ,92 C

ATOM 7005 N VAL G 175 28.523 49.939 -29.376 1.00 30, ,17 N

ATOM 7006 CA VAL G 175 28.311 49.068 -30.530 1.00 29, ,66 C

ATOM 7007 C VAL G 175 28.583 49.851 -31.809 1.00 28, ,77 c

ATOM 7008 o VAL G 175 28.223 51.024 -31.913 1.00 28. .77 o

ATOM 7009 CB VAL G 175 26.853 48.534 -30.583 1.00 29. ,73 c

ATOM 7010 CGI VAL G 175 26.675 47.614 -31.785 1.00 30. ,00 c

ATOM 7011 CG2 VAL G 175 26.530 47.784 -29.320 1.00 31. ,31 c

ATOM 7012 N LYS G 176 29.229 49.214 -32.776 1.00 28. ,41 N

ATOM 7013 CA LYS G 176 29.519 49.876 -34.046 1.00 28. ,60 C

ATOM 7014 C LYS G 176 29.178 48.979 -35.240 1.00 29, ,11 C

ATOM 7015 o LYS G 176 29.671 47.856 -35.342 1.00 28, ,32 o

ATOM 7016 CB LYS G 176 30.991 50.284 -34.117 1.00 29, ,21 C

ATOM 7017 N PHE G 177 28.313 49.473 -36.123 1.00 28, ,71 N

ATOM 7018 CA PHE G 177 27.929 48.736 -37.325 1.00 29, .28 C

ATOM 7019 C PHE G 177 28.592 49.414 -38.521 1.00 29, .86 C

ATOM 7020 o PHE G 177 28.617 50.645 -38.610 1.00 29. .26 o

ATOM 7021 CB PHE G 177 26.401 48.741 -37.522 1.00 28. .70 c

ATOM 7022 CG PHE G 177 25.641 47.975 -36.464 1.00 29. ,03 c

ATOM 7023 CDl PHE G 177 25.956 46.649 -36.186 1.00 28. .61 c

ATOM 7024 CD2 PHE G 177 24.617 48.578 -35.746 1.00 27. ,96 c

ATOM 7025 CEl PHE G 177 25.264 45.942 -35.210 1.00 28. .90 c

ATOM 7026 CE2 PHE G 177 23.921 47.881 -34.771 1.00 27. ,66 c

ATOM 7027 CZ PHE G 177 24.245 46.563 -34.502 1.00 28. ,37 c

ATOM 7028 N ARG G 178 29.127 48.617 -39.439 1.00 30. ,54 N

ATOM 7029 CA ARG G 178 29.780 49.169 -40.613 1.00 31. ,47 C

ATOM 7030 C ARG G 178 29.292 48.544 -41.914 1.00 30. ,95 C

ATOM 7031 o ARG G 178 28.922 47.374 -41.949 1.00 29. .97 o

ATOM 7032 CB ARG G 178 31.298 48.984 -40.515 1.00 34, .36 C

ATOM 7033 CG ARG G 178 31.931 49.644 -39.295 1.00 39, .90 C

ATOM 7034 CD ARG G 178 33.447 49.738 -39.439 1.00 43, .10 c

ATOM 7035 NE ARG G 178 33.818 50.394 -40.693 1.00 47, .10 N

ATOM 7036 CZ ARG G 178 35.069 50.570 -41.119 1.00 49, .58 C

ATOM 7037 NHl ARG G 178 36.096 50.141 -40.390 1.00 50. ,61 N

ATOM 7038 NH2 ARG G 178 35.292 51.172 -42.284 1.00 50. ,68 N

ATOM 7039 N CYS G 179 29.300 49.348 -42.976 1.00 30. .10 N

ATOM 7040 CA CYS G 179 28.925 48.904 -44.315 1.00 31. .02 C

ATOM 7041 C CYS G 179 29.848 49.628 -45.305 1.00 31. ,31 C

ATOM 7042 o CYS G 179 29.406 50.479 -46.087 1.00 28. ,70 o

ATOM 7043 CB CYS G 179 27.453 49.233 -44.593 1.00 31. ,15 C

ATOM 7044 SG CYS G 179 26.323 48.376 -43.429 1.00 33, ,32 S

ATOM 7045 N PRO G 180 31.154 49.303 -45.268 1.00 31, ,92 N

ATOM 7046 CA PRO G 180 32.110 49.953 -46.173 1.00 32, .72 C

ATOM 7047 C PRO G 180 31.664 49.828 -47.620 1.00 33, .18 C

ATOM 7048 o PRO G 180 31.438 48.731 -48.125 1.00 33, .64 o

ATOM 7049 CB PRO G 180 33.442 49.269 -45.843 1.00 32, ,69 C

ATOM 7050 CG PRO G 180 33.050 47.991 -45.187 1.00 33, .71 C

ATOM 7051 CD PRO G 180 31.832 48.342 -44.386 1.00 31, .74 C

ATOM 7052 N ALA G 181 31.507 50.974 -48.275 1.00 33. ,47 N

ATOM 7053 CA ALA G 181 31.027 50.985 -49.650 1.00 34. .74 C

ATOM 7054 C ALA G 181 31.848 51.813 -50.628 1.00 35. .80 C

ATOM 7055 o ALA G 181 32.599 52.709 -50.239 1.00 35, .32 o

ATOM 7056 CB ALA G 181 29.575 51.473 -49.674 1.00 33, .88 C

ATOM 7057 N GLY G 182 31.668 51.498 -51.909 1.00 36, .73 N

ATOM 7058 CA GLY G 182 32.338 52.206 -52.983 1.00 37, .08 C

ATOM 7059 C GLY G 182 31.282 52.606 -53.999 1.00 38, .28 C TabU 3

ATOM 7060 o GLY G 182 30.121 52.197 -53.884 1.00 37.01 o

ATOM 7061 N GLY G 183 31.674 53.404 -54.989 1.00 38.76 N

ATOM 7062 CA GLY G 183 30.734 53.838 -56.010 1.00 39.76 C

ATOM 7063 C GLY G 183 31.086 55.189 -56.613 1.00 40.59 C

ATOM 7064 o GLY G 183 31.746 56.011 -55.979 1.00 40.19 o

ATOM 7065 N ASN G 184 30.636 55.424 -57.841 1.00 41.17 N

ATOM 7066 CA ASN G 184 30.909 56.678 -58.529 1.00 41.73 C

ATOM 7067 C ASN G 184 29.700 57.116 -59.342 1.00 41.90 C

ATOM 7068 o ASN G 184 29.334 56.478 -60.321 1.00 41.81 o

ATOM 7069 CB ASN G 184 32.140 56.527 -59.433 1.00 42.19 C

ATOM 7070 CG ASN G 184 32.410 57.766 -60.279 1.00 43.50 C

ATOM 7071 ODl ASN G 184 31.973 58.875 -59.953 1.00 44.29 o

ATOM 7072 ND2 ASN G 184 33.147 57.581 -61.368 1.00 43.66 N

ATOM 7073 N PRO G 185 29.088 58.245 -58.962 1.00 42.45 N

ATOM 7074 CA PRO G 185 29.466 59.115 -57.846 1.00 43.00 C

ATOM 7075 C PRO G 185 29.365 58.488 -56.455 1.00 43.89 c

ATOM 7076 o PRO G 185 28.707 57.457 -56.261 1.00 44.36 o

ATOM 7077 CB PRO G 185 28.522 60.303 -58.012 1.00 43.19 c

ATOM 7078 CG PRO G 185 27.292 59.663 -58.551 1.00 43.35 c

ATOM 7079 CD PRO G 185 27.844 58.720 -59.594 1.00 42.63 c

ATOM 7080 N MET G 186 30.021 59.128 -55.492 1.00 44.05 N

ATOM 7081 CA MεT G 186 30.020 58.666 -54.111 1.00 44.25 C

ATOM 7082 C M T G 186 28.606 58.465 -53.600 1.00 42.98 C

ATOM 7083 o M T G 186 27.810 59.403 -53.552 1.00 42.87 o

ATOM 7084 CB MET G 186 30.738 59.675 -53.214 1.00 46.35 C

ATOM 7085 CG MET G 186 32.139 59.258 -52.808 1.00 50.04 c

ATOM 7086 SD MET G 186 32.148 57.751 -51.802 1.00 52.71 S

ATOM 7087 CE MET G 186 32.923 56.587 -52.955 1.00 51.94 c

ATOM 7088 N PRO G 187 28.267 57.232 -53.213 1.00 41.91 N

ATOM 7089 CA PRO G 187 26.917 56.975 -52.708 1.00 41.20 c

ATOM 7090 C PRO G 187 26.649 57.562 -51.319 1.00 40.70 c

ATOM 7091 o PRO G 187 27.570 57.776 -50.530 1.00 39.93 o

ATOM 7092 CB PRO G 187 26.816 55.447 -52.737 1.00 41.16 c

ATOM 7093 CG PRO G 187 28.227 55.001 -52.572 1.00 41.50 c

ATOM 7094 CD PRO G 187 28.999 55.971 -53.438 1.00 41.38 c

ATOM 7095 N THR G 188 25.378 57.839 -51.044 1.00 40.29 N

ATOM 7096 CA THR G 188 24.976 58.375 -49.754 1.00 40.62 C

ATOM 7097 C THR G 188 24.623 57.203 -48.849 1.00 40.45 C

ATOM 7098 o THR G 188 24.425 56.084 -49.322 1.00 40.89 o

ATOM 7099 CB THR G 188 23.747 59.299 -49.892 1.00 40.91 C

ATOM 7100 OG1 THR G 188 22.685 58.591 -50.544 1.00 41.24 o

ATOM 7101 CG2 THR G 188 24.103 60.538 -50.704 1.00 40.28 c

ATOM 7102 N MET G 189 24.552 57.459 -47.551 1.00 40.54 N

ATOM 7103 CA MET G 189 24.218 56.414 -46.603 1.00 40.70 C

ATOM 7104 C MET G 189 23.158 56.852 -45.613 1.00 40.06 C

ATOM 7105 0 MET G 189 23.178 57.983 -45.124 1.00 40.47 o

ATOM 7106 CB MET G 189 25.454 55.958 -45.836 1.00 43.01 C

ATOM 7107 CG MεT G 189 25.120 54.977 -44.729 1.00 46.26 C

ATOM 7108 SD MET G 189 26.578 54.334 -43.921 1.00 51.42 s

ATOM 7109 CE MET G 189 26.573 52.656 -44.569 1.00 48.28 c

ATOM 7110 N ARG G 190 22.229 55.944 -45.331 1.00 38.37 N

ATOM 7111 CA ARG G 190 21.156 56.193 -44.379 1.00 37.86 C

ATOM 7112 C ARG G 190 20.976 54.940 -43.522 1.00 35.87 C

ATOM 7113 0 ARG G 190 21.118 53.823 -44.029 1.00 35.22 o

ATOM 7114 CB ARG G 190 19.846 56.487 -45.108 1.00 39.91 C

ATOM 7115 CG ARG G 190 19.989 57.359 -46.335 1.00 44.33 C

ATOM 7116 CD ARG G 190 18.650 58.006 -46.693 1.00 47.36 c

ATOM 7117 NE ARG G 190 17.538 57.053 -46.736 1.00 49.72 N

ATOM 7118 CZ ARG G 190 17.388 56.103 -47.657 1.00 50.89 c

ATOM 7119 NHl ARG G 190 18.283 55.960 -48.627 1.00 51.57 N

ATOM 7120 NH2 ARG G 190 16.329 55.303 -47.617 1.00 51.62 N

ATOM 7121 N TRP G 191 20.658 55.127 -42.242 1.00 33.21 N TOM 7122 CA TRP G 191 20.450 54.005 -41.329 1.00 32.38 C

ATOM 7123 C TRP G 191 19.009 53.896 -40.842 1.00 31.73 C

ATOM 7124 0 TRP G 191 18.397 54.893 -40.474 1.00 32.66 o

ATOM 7125 CB TRP G 191 21.373 54.140 -40.118 1.00 32.19 C

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

ι ιπιnιπιoiΛinι ι ιnι uiιnιoιoιoιfl^ι>ιoιθιoι ιoιnι ^^"i^,"f "j'^^^"r*ιπι ιπιoιnιnιnιnιnιπι tniΛΦΦΦi ιoι ι ιo

0"ι^|l. lCDO)"l'<f ^oσlΦoσι90lJld(M^σ)lIl<Λ o (ηood o<J O^( lno^l Ol^ln^^^ιno <ι^ιcιιπln1<' Φ >ι^ι< f^,ιm ιDιnιno ON ( (Il nmH^oeolnΦΦln H^ι^ιeo ι^,)ι^,l( o( mιOHon^^ΦΦιn(Iι^n^ι^,ood^ooM ι^ ^ιι^ι^,l !Mι»ld lndι»ι^ ln»a)f d Λ ιIι^'^^l»ι^o <Iln»HoσlNι ιnfflHιJllnlΛm^ "l' lnπ "l'^o^M^,)p'C l O ldOlddιn ιnoωωal^^ln^r^ΦlnNd"l^M<Il

CM< rθ'T"* ιnr ιn )r-~ r-- r~cDcDιnιncDι ι (θιnι ιnι ι 'r cMHCMr r cMro MCMHCM rη'rθf i''j"M

CMCMCMCMCMCMCMCMCMHHHHHHHHHHHHHHH HHHHHHHHHHHHH HHH HHHHHHHHHHHHHHHHHHHHCMHHHHH

HHHHHHHHH( N(MCιw(M lNMMf^^ ^(r)M^(y ι^{η p}^^ ^Hf ^"]^»"r^^ιnlnlΛln ΦΦ ^^^r.^ •r• ■oococDoo ooooocDQoωa^σ ^3l ft Λσ <7 σ iτι<xισ a σ σισ <xtσϊσϊσ a>a Λi^σι^σϊ^^<Λ<j <Λc^yι<Λσισισ Λσισι<τvcΛCϊ^σϊCΛσ^c^σϊσ σ^<^

OUCJ)CDUCDOO OUU O Ci> 0 _tO U O _ιO U OCJ)OOCDCJ) CJ)UCJ)UOOCDU O CI>O O CJ) 0 Oj ftj a.C CLj C-. ajai PD D D D DD DD D CO CO COCO CO COCO >H W COCOCO eo D D D D D DDD D H W W WW WWW WIxl WCO COCO pι; B; ^pή Pi:c-; o; pι:rt iϊ: i-i ω ω ωω ωw w < < >H < < H H hfιHh HHt< H E<J ιJ ι4ιJ JJJιJ J J J ιJ J JJ OJιJ JJιJ 5 U UU - U

H CM H CM ΓO CM C CM H CM H CM H CM H CM H CM

UQ Dω H u iN a ft to o a a rt O U QB N rt PQ CD Q Q t < < m o a ω ω tt mo QQW H n ft c^j u u z c^jc^j u u oz o υouoυυzo υooo oo z z υoo ooo z z uo o z u u o uzυ υ oυo u oo z υυouυcj uυuo zcjo ^φ^σ>OiOHN⁽¹^^ιfl M!oσ^o lM^(ϊl^lπ ^oDmo ^ι^^ι^ιn ^o}σ\OH( f ^ιnΦ^ D^3 oH( c ^ln Moσ^od(Mιl^^|ιπΦ a3moH cMC CMCMc r c ^p foc ror cof ι ι^{, ,} '^pι^,'^'r ^ι 'r Lθι ι Lnιnιθιnιnι ι cDCDCDCDCDCDioιococoι^ r-r^r^ r^r^r^

00 HHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH rH r--r ι^f^r r-. r-- r- r^ r- ι^r-- [^ r--r-- r^r^ r r^ r r^[^ r^ r^ r-r^ r-r^r^r^r^r^r^r' r^ r^ r^ r^

OaOεεOεOaεOOa ε εε o OOa aOOaaOOOεεOOaaOaOOaOεOOOaεOεOOε it ft ft < < < ft ft < ft ft ft < ft < ft < ft ft ft < < ft < <

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H H H H , I H H H H H H ,

H <M co r- co co o oo r- r- «Hm O CM lO CO "3" CΛ CO oooo oooo -mo cM co σι oo H θ r- C01' '>' r0 CM O CM O CM O CM CM CN CN CN CM CN CM CM CM

AO< a A oι ι!t o o o o o o o o o d H d H H H d H M N <4 N l N N NN N n n ι n n « « « M^| v « 9 « ιn ι in ι'l ^βι «v r^■ ^* ^■ r'

CT> σι σι σ> CΛ <T> 000000000000000000000000000000000000000000000000000000000000 H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C CM CM CM CM CM CM C^

O O CJ⁾ CD O O CD CJ) CD O CD O O U CJ⁾ O CJ) O CD CJ) CD CD CD O U O CD O CJ)

CO CO CO O CO CO Z Z Z Z Z Z Z Z Z D D D D D D D D D C0 C0 C0 C0 C0 C0 C0 C0 C0 W O O O O [d ω ω W H W W W ^ >H < >H H H >H >H Cή P£j p, p£j p, rt p, rt

X X X X X X O O C) tJ) CD ϋ U O CD U O CJ) CD O O X K X W X X X W X X rt rt rt rt rt H H H H H H H H U O O CJ) O D C EH EH eH EH EH H H H EH EH EH

o

oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

HHHHHHHHHHH HHHHHHHHHHHHHH

ininini i i i i cDCDi i i cDinintninini inini inininiDvoin Di inini ini i i i i inini i ioininininini ininini in^

- ro(D _ lD(D "]' ιn ιfl fl ιfl lfl ι Φ Φ - O OO O O O O H H H H H H H H H H H H H CN CM CN CM CM CM CM ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

B; tn w w ιn ι ι m n w J j j _lj j j j o ι o u oz z z z z z z z z z z z z wn ι (o ιn Λftιaι θι θι θι aι i- (- ι- cι_< ι- ι- ι- a a Λ < H l rH H >H H >H >H >H rt rt rt rt rt rt rt C-| Cl5 PCi Cl5 CCi ra O W O H Ha Hl _l_l lJ H H H H H Pc; n

EH r rJ j i j H-l H^ H^ H^ > > > > > > rt rt rt rt rt rt rt rt rt rt rt rt rt D C) ) O X X ffi a K EH EH H EH EH EH H H H EH H H EH EH W

H CM H CM H CM H CM CO CM CO CM x rt co CJ> a ω co < PQ CD CD rt PQ < PQ O O O m ft m ft ca u Q Q ω ω ω N N i ; PO CD < PQ CD ozooouυcjυzzυuouuozcjc ocjzυυoouozzoυoozuooozooouuυυzooυυυzυuouozooouo ω <ωIl oOllOOdd (Nιιη»ι

, inΛ HH HdNC NCM«C (M oo CM t-

© oεεoεoaoaoosaoaoaoεoossoaoaoaoεoEoaoaoaoEooεoεεoεooεεoεoεoεoεoεooεεoεoεoεoεoaεoεooεεooεεoEooεoεoεoεoεεoε o o ooεoaaooaoaoaεooεaoaooεoεoε it ft ft < ft it ft < < 't < < < < < ft r ft ft it ft t t ft t t it ' t

o cjozυυooυoυzυυoooOTUzυoocjoooozcjoouozuυooucjzυυoouυzuuocjoυzυoooozυuooυ

^ ιl ^ o σt σl σϊΦ O "ϊ^, l fl ιπ(M ιnσι o fιn nn"l^l COCO ro rOCO COCO CO COCO CO COCO oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

N o O o c σl (M Φ Φ w Φ H o cM φ φ o rO rO I I I I I

Φ ^ o ι _ ^Λ n d σl ιη (D ι^,^ Φ

^ ^l ιJ^ o ιn ι O « σι _ H

vιJ 'l^ιιrι lnlnlΛιnιo H CM CM CM CM CM CM CM CM CM CM o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o

D D H Cd ia w ia w W H EH EH EH EH EH EH eH EH D D D D D D D D D fi PS j j _Ki j j.j j j j j j j Ki oo o o o o o i.i. ot iϊ iϋ Λ Oi i. ς.ft n o, w w ri ti j j _Ki j _tj j H H P W H W H W j j j j j ij j j ja w < rt rt rt < ft , rt, rt , rt , rt Pή tf -. p-$. Λ-. -.; o-G. Q-5 ω w ω ω ω iy co co o co w -) ι-i pi H H H H H H H H a a a a a a a cD CD D cD c cD co c >>>>>>>> > > > > > c Dj C_ c_ c_ ai CLi c co co cn co co rt rt rt rt rt rt

H CM H CM H H CM H CM H CM

Q O ft CQ CD CD O ft PQ CD Q W ft CQ CD Q Cd Cxl ft PQ CD PQ CJ) CD CQ CD ID ft C^Q CD ^Q rt CQ C oυzυυooooυzcjυoouwcjzuυouc cjoozouoυozuυouuuzuooooυz υooυυozυ oooDzortuou CQ CuJ) cιl oo

εo

Table 3

ATOM 7390 ODl ASP G 225 19.312 51.661 -27.760 1.00 34.35 o

ATOM 7391 OD2 ASP G 225 20.744 50.832 -26.328 1.00 33.86 o

ATOM 7392 N LYS G 226 17.634 46.630 -28.436 1.00 33.97 N

ATOM 7393 CA LYS G 226 17.460 45.415 -29.238 1.00 33.58 C

ATOM 7394 C LYS G 226 16.601 45.713 -30.452 1.00 32.76 C

ATOM 7395 o LYS G 226 15.591 46.410 -30.348 1.00 33.24 0

ATOM 7396 CB LYS G 226 16.782 44.311 -28.420 1.00 34.76 C

ATOM 7397 N GLY G 227 17.002 45.187 -31.604 1.00 31.91 N

ATOM 7398 CA GLY G 227 16.240 45.404 -32.818 1.00 31.44 C

ATOM 7399 C GLY G 227 17.077 45.219 -34.073 1.00 32.34 C

ATOM 7400 o GLY G 227 18.197 44.694 -34.010 1.00 32.28 o

ATOM 7401 N ASN G 228 16.533 45.643 -35.211 1.00 31.51 N

ATOM 7402 CA ASN G 228 17.231 45.543 -36.485 1.00 31.35 C

ATOM 7403 C ASN G 228 17.734 46.889 -36.940 1.00 30.18 C

ATOM 7404 o ASN G 228 17.019 47.885 -36.845 1.00 31.12 o

ATOM 7405 CB ASN G 228 16.316 44.998 -37.568 1.00 32.51 c

ATOM 7406 CG ASN G 228 15.927 43.586 -37.311 1.00 34.95 c TOM 7407 ODl ASN G 228 16.696 42.829 -36.730 1.00 35.67 o

ATOM 7408 ND2 ASN G 228 14.732 43.206 -37.745 1.00 36.62 N

ATOM 7409 N TYR G 229 18.965 46.911 -37.436 1.00 28.15 N

ATOM 7410 CA TYR G 229 19.568 48.135 -37.933 1.00 28.01 C

ATOM 7411 C TYR G 229 20.032 47.899 -39.365 1.00 27.46 C

ATOM 7412 o TYR G 229 20.885 47.053 -39.630 1.00 26.42 o

ATOM 7413 CB TYR G 229 20.721 48.568 -37.021 1.00 28.59 C

ATOM 7414 CG TYR G 229 20.240 48.915 -35.629 1.00 29.21 C

ATOM 7415 CDl TYR G 229 20.033 47.925 -34.672 1.00 29.80 C

ATOM 7416 CD2 TYR G 229 19.915 50.229 -35.293 1.00 30.39 C

ATOM 7417 CEl TYR G 229 19.505 48.236 -33.415 1.00 30.65 C

ATOM 7418 cε2 TYR G 229 19.391 50.553 -34.040 1.00 29.83 C

ATOM 7419 CZ TYR G 229 19.188 49.552 -33.108 1.00 30.76 C

ATOM 7420 OH TYR G 229 18.659 49.867 -31.872 1.00 32.33 o

ATOM 7421 N THR G 230 19.449 48.666 -40.282 1.00 26.96 N

ATOM 7422 CA THR G 230 19.729 48.536 -41.705 1.00 26.33 C

ATOM 7423 C THR G 230 20.432 49.731 -42.326 1.00 26.67 C

ATOM 7424 o THR G 230 20.049 50.878 -42.097 1.00 26.83 o

ATOM 7425 CB THR G 230 18.405 48.316 -42.456 1.00 27.36 C

ATOM 7426 OG1 THR G 230 17.794 47.102 -41.986 1.00 27.11 o

ATOM 7427 CG2 THR G 230 18.624 48.262 -43.966 1.00 26.38 C

ATOM 7428 N CYS G 231 21.463 49.466 -43.120 1.00 27.19 N

ATOM 7429 CA CYS G 231 22.168 50.549 -43.802 1.00 27.64 C

ATOM 7430 C CYS G 231 21.734 50.506 -45.268 1.00 27.64 C

ATOM 7431 o CYS G 231 21.714 49.442 -45.889 1.00 27.09 o

ATOM 7432 CB CYS G 231 23.687 50.362 -43.715 1.00 29.07 c

ATOM 7433 SG CYS G 231 24.273 48.894 -44.592 1.00 31.30 s

ATOM 7434 N VAL G 232 21.361 51.665 -45.802 1.00 28.82 N

ATOM 7435 CA VAL G 232 20.943 51.801 -47.200 1.00 29.71 C

ATOM 7436 C VAL G 232 21.951 52.730 -47.897 1.00 30.46 C

ATOM 7437 o VAL G 232 22.177 53.858 -47.457 1.00 29.38 O

ATOM 7438 CB VAL G 232 19.520 52.421 -47.317 1.00 29.90 C

ATOM 7439 CGI VAL G 232 19.074 52.407 -48.776 1.00 29.33 C

ATOM 7440 CG2 VAL G 232 18.529 51.641 -46.448 1.00 29.15 C

ATOM 7441 N VAL G 233 22.557 52.247 -48.978 1.00 30.43 N

ATOM 7442 CA VAL G 233 23.561 53.021 -49.695 1.00 31.82 C

ATOM 7443 C VAL G 233 23.155 53.193 -51.154 1.00 32.71 c

ATOM 7444 o VAL G 233 22.792 52.223 -51.819 1.00 33.76 o

ATOM 7445 CB VAL G 233 24.949 52.333 -49.554 1.00 30.72 c

ATOM 7446 CGI VAL G 233 26.000 53.059 -50.359 1.00 30.29 c

ATOM 7447 CG2 VAL G 233 25.353 52.328 -48.070 1.00 30.62 c

ATOM 7448 N GLU G 234 23.201 54.424 -51.653 1.00 33.51 N

ATOM 7449 CA GLU G 234 22.775 54.655 -53.025 1.00 35.10 C

ATOM 7450 C GLU G 234 23.320 55.855 -53.796 1.00 34.23 C

ATOM 7451 o GLU G 234 23.822 56.826 -53.229 1.00 34.30 o

ATOM 7452 CB GLU G 234 21.246 54.698 -53.068 1.00 37.35 C

ATOM 7453 CG GLU G 234 20.648 55.776 -52.190 1.00 40.83 C

ATOM 7454 CD GLU G 234 19.198 55.499 -51.810 1.00 44.47 C

ATOM 7455 OBI GLU G 234 18.643 56.288 -51.012 1.00 44.70 o Table 3

ATOM 7456 oε2 GLU G 234 18.616 54.496 -52.295 1.00 44.42 0

ATOM 7457 N ASN G 235 23.221 55.737 -55.116 1.00 34.32 N

ATOM 7458 CA ASN G 235 23.623 56.772 -56.065 1.00 34.06 C

ATOM 7459 C ASN G 235 22.688 56.604 -57.264 1.00 34.55 C

ATOM 7460 o ASN G 235 21.763 55.780 -57.216 1.00 33.77 o

ATOM 7461 CB ASN G 235 25.116 56.656 -56.474 1.00 32.59 C

ATOM 7462 CG ASN G 235 25.446 55.400 -57.288 1.00 32.92 c

ATOM 7463 ODl ASN G 235 24.578 54.736 -57.843 1.00 32.10 o

ATOM 7464 ND2 ASN G 235 26.738 55.095 -57.382 1.00 32.83 N

ATOM 7465 N GLU G 236 22.917 57.366 -58.330 1.00 35.00 N

ATOM 7466 CA GLU G 236 22.070 57.312 -59.524 1.00 35.86 C

ATOM 7467 C GLU G 236 21.952 55.943 -60.214 1.00 36.60 C

ATOM 7468 o GLU G 236 20.968 55.684 -60.910 1.00 36.50 o

ATOM 7469 CB GLU G 236 22.558 58.340 -60.557 1.00 35.14 C

ATOM 7470 N TYR G 237 22.944 55.073 -60.028 1.00 36.16 N

ATOM 7471 CA TYR G 237 22.919 53.755 -60.665 1.00 36.25 C TOM 7472 C TYR G 237 22.503 52.583 -59.780 1.00 35.75 C

ATOM 7473 o TYR G 237 22.574 51.436 -60.215 1.00 35.24 o

ATOM 7474 CB TYR G 237 24.284 53.425 -61.279 1.00 36.51 C

ATOM 7475 CG TYR G 237 24.811 54.520 -62.154 1.00 38.18 C

ATOM 7476 CDl TYR G 237 25.831 55.355 -61.708 1.00 38.95 C

ATOM 7477 CD2 TYR G 237 24.239 54.775 -63.400 1.00 37.89 c

ATOM 7478 cεi TYR G 237 26.270 56.421 -62.478 1.00 40.57 c

ATOM 7479 CE2 TYR G 237 24.661 55.836 -64.174 1.00 39.83 c

ATOM 7480 CZ TYR G 237 25.680 56.663 -63.705 1.00 41.20 c

ATOM 7481 OH TYR G 237 26.095 57.745 -64.450 1.00 42.74 o

ATOM 7482 N GLY G 238 22.082 52.842 -58.548 1.00 34.93 N

ATOM 7483 CA GLY G 238 21.677 51.723 -57.719 1.00 34.22 C

ATOM 7484 C GLY G 238 21.493 51.987 -56.242 1.00 33.59 C

ATOM 7485 o GLY G 238 21.898 53.026 -55.719 1.00 34.04 o

ATOM 7486 N SER G 239 20.887 51.011 -55.575 1.00 32.54 N

ATOM 7487 CA SER G 239 20.616 51.076 -54.146 1.00 32.28 C

ATOM 7488 C SER G 239 20.735 49.675 -53.544 1.00 31.72 C

ATOM 7489 o SER G 239 20.105 48.735 -54.029 1.00 31.16 o

ATOM 7490 CB SER G 239 19.210 51.617 -53.908 1.00 32.19 c

ATOM 7491 OG SER G 239 18.886 51.583 -52.532 1.00 34.32 o

ATOM 7492 N ILE G 240 21.551 49.538 -52.498 1.00 30.28 N

ATOM 7493 CA ILE G 240 21.747 48.247 -51.835 1.00 28.68 C

ATOM 7494 C ILE G 240 21.654 48.410 -50.321 1.00 28.11 C

ATOM 7495 o ILE G 240 21.912 49.483 -49.798 1.00 28.31 o

ATOM 7496 CB ILE G 240 23.128 47.621 -52.181 1.00 27.78 C

ATOM 7497 CGI ILE G 240 24.268 48.533 -51.702 1.00 27.45 C

ATOM 7498 CG2 ILE G 240 23.219 47.361 -53.663 1.00 26.24 C

ATOM 7499 CDl ILE G 240 25.679 48.024 -52.049 1.00 26.01 c

ATOM 7500 N ASN G 241 21.279 47.343 -49.623 1.00 28.01 N

ATOM 7501 CA ASN G 241 21.152 47.393 -48.170 1.00 27.97 C

ATOM 7502 C ASN G 241 21.662 46.128 -47.474 1.00 27.84 C

ATOM 7503 o ASN G 241 21.829 45.082 -48.098 1.00 27.55 o

ATOM 7504 CB ASN G 241 19.693 47.622 -47.773 1.00 27.81 c

ATOM 7505 CG ASN G 241 18.771 46.552 -48.317 1.00 29.79 c

ATOM 7506 ODl ASN G 241 18.122 46.736 -49.362 1.00 31.16 o

ATOM 7507 ND2 ASN G 241 18.717 45.419 -47.630 1.00 28.96 N

ATOM 7508 N HIS G 242 21.884 46.245 -46.167 1.00 27.95 N

ATOM 7509 CA HIS G 242 22.367 45.146 -45.334 1.00 27.69 C

ATOM 7510 C HIS G 242 21.748 45.312 -43.949 1.00 26.95 C

ATOM 7511 o HIS G 242 21.585 46.421 -43.474 1.00 26.62 o

ATOM 7512 CB HIS G 242 23.888 45.223 -45.226 1.00 28.03 C

ATOM 7513 CG HIS G 242 24.485 44.178 -44.337 1.00 29.55 C

ATOM 7514 ND1 HIS G 242 24.727 42.889 -44.762 1.00 29.30 N

ATOM 7515 CD2 HIS G 242 24.886 44.231 -43.043 1.00 29.73 C

ATOM 7516 CEl HIS G 242 25.252 42.193 -43.769 1.00 29.52 C

ATOM 7517 NE2 HIS G 242 25.359 42.983 -42.716 1.00 29.51 N

ATOM 7518 N THR G 243 21.418 44.214 -43.286 1.00 27.81 N

ATOM 7519 CA THR G 243 20.789 44.322 -41.983 1.00 28.78 c

ATOM 7520 C THR G 243 21.498 43.589 -40.853 1.00 29.90 ^' c

ATOM 7521 o THR G 243 21.907 42.432 -40.994 1.00 29.15 o Table 3

ATOM 7522 CB THR G 243 19.318 43.848 -42.051 1, .00 29. .58 C

ATOM 7523 OG1 THR G 243 18.584 44.714 -42.931 1. .00 28. .66 O

ATOM 7524 CG2 THR G 243 18.681 43.873 -40.670 1, .00 27. ,96 C

ATOM 7525 N TYR G 244 21.639 44.300 -39.736 1. .00 30. ,30 N

ATOM 7526 CA TYR G 244 22.269 43.789 -38.530 1, .00 32. ,40 C

ATOM 7527 C TYR G 244 21.192 43.618 -37.463 1. .00 34. ,01 C

ATOM 7528 o TYR G 244 20.216 44.379 -37.433 1, .00 33, ,67 O

ATOM 7529 CB TYR G 244 23.304 44.789 -38.004 1, .00 33, ,37 C

ATOM 7530 CG TYR G 244 24.582 44.848 -38.803 1. .00 34, ,79 C

ATOM 7531 CDl TYR G 244 24.986 46.029 -39.422 1, .00 34, .97 C

ATOM 7532 CD2 TYR G 244 25.396 43.719 -38.935 1, .00 34, .57 C

ATOM 7533 CEl TYR G 244 26.180 46.089 -40.158 1, .00 35, ,52 C

ATOM 7534 CE2 TYR G 244 26.584 43.764 -39.661 1, .00 35, .11 C

ATOM 7535 CZ TYR G 244 26.970 44.950 -40.269 1. .00 35. .69 C

ATOM 7536 OH TYR G 244 28.147 45.001 -40.973 1. .00 35. .60 O

ATOM 7537 N HIS G 245 21.376 42.635 -36.590 1. .00 34. ,92 N

ATOM 7538 CA HIS G 245 20.442 42.396 -35.491 1. .00 36. .03 C

ATOM 7539 C HIS G 245 21.217 42.634 -34.196 1, .00 35. .26 C

ATOM 7540 o HIS G 245 22.309 42.093 -34.019 1. .00 34, .39 O

ATOM 7541 CB HIS G 245 19.919 40.953 -35.545 1, .00 38, ,91 C

ATOM 7542 CG HIS G 245 19.299 40.594 -36.864 1, .00 42, ,97 C

ATOM 7543 ND1 HIS G 245 18.057 41.050 -37.249 1, .00 45. .08 N

ATOM 7544 CD2 HIS G 245 19.777 39.882 -37.912 1, .00 44, .45 C

ATOM 7545 CEl HIS G 245 17.797 40.643 -38.483 1, .00 44. ,93 C TOM 7546 NE2 HIS G 245 18.831 39.935 -38.908 1, .00 45, .92 N

ATOM 7547 N Lεu G 246 20.667 43.456 -33.306 1, .00 34, .64 N

ATOM 7548 CA LEU G 246 21.333 43.748 -32.043 1, .00 34, ,91 C

ATOM 7549 C LEU G 246 20.606 43.181 -30.825 1, .00 35, .69 c

ATOM 7550 o LEU G 246 19.384 43.278 -30.713 1, .00 35. ,58 o

ATOM 7551 CB LEU G 246 21.494 45.260 -31.862 1, .00 35. .44 c

ATOM 7552 CG LEU G 246 22.063 45.734 -30.517 1. .00 36. .47 c

ATOM 7553 CDl LEU G 246 23.469 45.183 -30.336 1. .00 36. .34 c

ATOM 7554 CD2 Lεu G 246 22.076 47.253 -30.460 00 35.04 c

ATOM 7555 N ASP G 247 21.369 42.587 -29.913 00 36.18 N

ATOM 7556 CA ASP G 247 20.816 42.051 -28.681 00 37.30 C

ATOM 7557 C ASP G 247 21.720 42.476 -27.527 00 37. .80 C

ATOM 7558 o ASP G 247 22.947 42.445 -27.638 00 37..40 O

ATOM 7559 CB ASP G 247 20.715 40.532 -28.732 00 39.92 C

ATOM 7560 CG ASP G 247 19.307 40.044 -28.452 00 41.73 c

ATOM 7561 ODl ASP G 247 18.633 39.593 -29.404 1.00 42.63 o

ATOM 7562 OD2 ASP G 247 18.871 40.127 -27.282 1.00 42.31 o

ATOM 7563 N VAL G 248 21.111 42.891 -26.423 1.00 37.48 N

ATOM 7564 CA VAL G 248 21.876 43.331 -25.268 1.00 37.97 C

ATOM 7565 C VAL G 248 21.620 42.443 -24.059 00 38.56 C

ATOM 7566 o VAL G 248 20.473 42.099 -23.762 00 38.74 o

ATOM 7567 CB VAL G 248 21.530 44.796 -24.904 1.00 38.63 c

ATOM 7568 CGI VAL G 248 22.373 45.261 -23.724 1.00 37.78 c

ATOM 7569 CG2 VAL G 248 21.775 45.695 -26.110 1.00 38.73 c

ATOM 7570 N VAL G 249 22.696 42.078 -23.364 1.00 38.33 N

ATOM 7571 CA VAL G 249 22.595 41.228 -22.186 1.00 38.35 C

ATOM 7572 C VAL G 249 23.224 41.900 -20.964 1.00 38.07 C

ATOM 7573 o VAL G 249 24.374 42.338 -21.000 1.00 37.99 O

ATOM 7574 CB VAL G 249 23.286 39.868 -22.422 1.00 39.59 C

ATOM 7575 CGI VAL G 249 23.101 38.982 -21.209 1.00 40.52 C

ATOM 7576 CG2 VAL G 249 22.708 39.192 -23.662 1.00 39.36 c

ATOM 7577 N GLU G 250 22.462 41.991 -19.880 1.00 37.91 N

ATOM 7578 CA GLU G 250 22.974 42.605 -18.665 1.00 37.55 c

ATOM 7579 C GLU G 250 23.748 41.569 -17.876 1.00 37.14 c

ATOM 7580 o GLU G 250 23.253 40.469 -17.621 1.00 36.70 o

ATOM 7581 CB GLU G 250 21.837 43.154 -17.798 1.00 39.01 c

ATOM 7582 CG GLU G 250 21.151 44.384 -18.372 1.00 41.78 c

ATOM 7583 CD GLU G 250 19.883 44.749 -17.620 1.00 43.62 c

ATOM 7584 OBI GLU G 250 18.917 43.948 -17.651 1.00 44.58 o

ATOM 7585 oε2 GLU G 250 19.858 45.831 -17.000 1.00 44.67 o

ATOM 7586 N ARG G 251 24.972 41.916 -17.501 1.00 35.77 N

ATOM 7587 CA ARG G 251 25.795 41.008 -16.730 1.00 35.07 C Table 3

ATOM 7588 C ARG G 251 25.875 41.462 -15.282 1.00 35.93 c

ATOM 7589 o ARG G 251 25.762 42.656 -14.981 1.00 36.05 0 TOM 7590 CB ARG G 251 27.218 40.907 -17.314 1.00 33.17 c

ATOM 7591 CG ARG G 251 27.311 40.440 -18.771 1.00 30.95 c

ATOM 7592 CD ARG G 251 26.466 39.204 -19.068 1.00 29.63 c

ATOM 7593 ε ARG G 251 26.826 38.035 -18.268 1.00 27.31 N

ATOM 7594 CZ ARG G 251 27.877 37.261 -18.507 1.00 28.64 C

ATOM 7595 NHl ARG G 251 28.683 37.530 -19.528 1.00 29.00 N

ATOM 7596 NH2 ARG G 251 28.120 36.206 -17.732 1.00 28.89 N

ATOM 7597 N SER G 252 26.071 40.477 -14.404 1.00 36.15 N

ATOM 7598 CA SER G 252 26.204 40.717 -12.978 1.00 36.84 C

ATOM 7599 C SER G 252 27.497 40.097 -12.438 1.00 37.21 C

ATOM 7600 o SER G 252 27.544 38.919 -12.112 1.00 37.64 o

ATOM 7601 CB SER G 252 25.020 40.122 -12.217 1.00 36.67 C

ATOM 7602 OG SER G 252 25.289 40.169 -10.825 1.00 38.12 o

ATOM 7603 N PRO G 253 28.562 40.897 -12.319 1.00 37.48 N

ATOM 7604 CA PRO G 253 29.847 40.407 -11.816 1.00 37.21 C

ATOM 7605 C PRO G 253 29.925 40.268 -10.288 1.00 37.55 C

ATOM 7606 o PRO G 253 30.909 40.681 -9.678 1.00 37.38 o

ATOM 7607 CB PRO G 253 30.820 41.462 -12.329 1.00 37.06 C

ATOM 7608 CG PRO G 253 30.026 42.718 -12.121 1.00 37.41 C

ATOM 7609 CD PRO G 253 28.639 42.336 -12.640^' 1.00 37.48 C

ATOM 7610 N HIS G 254 28.907 39.686 -9.667 1.00 37.32 N

ATOM 7611 CA HIS G 254 28.918 39.538 -8.214 1.00 37.41 C

ATOM 7612 C HIS G 254 29.057 38.081 -7.782 1.00 35.91 C

ATOM 7613 o HIS G 254 28.788 37.161 -8.558 1.00 34.13 o

ATOM 7614 CB HIS G 254 27.624 40.098 -7.606 1.00 39.83 C

ATOM 7615 CG HIS G 254 27.299 41.496 -8.033 1.00 43.05 C

ATOM 7616 ND1 HIS G 254 26.937 41.818 -9.325 1.00 44.40 N

ATOM 7617 CD2 HIS G 254 27.256 42.655 -7.332 1.00 44.17 C

ATOM 7618 CEl HIS G 254 26.680 43.114 -9.400 1.00 44.30 C

ATOM 7619 NE2 HIS G 254 26.866 43.644 -8.205 1.00 44.52 N

ATOM 7620 N ARG G 255 29.493 37.874 -6.544 1.00 34.42 N

ATOM 7621 CA ARG G 255 29.588 36.515 -6.015 1.00 34.16 C

ATOM 7622 C ARG G 255 28.121 36.111 -5.763 1.00 32.44 C

ATOM 7623 o ARG G 255 27.234 36.966 -5.773 1.00 31.37 o

ATOM 7624 CB ARG G 255 30.409 36.501 -4.717 1.00 35.31 C

ATOM 7625 CG ARG G 255 29.797 37.258 -3.545 1.00 39.42 C

ATOM 7626 CD ARG G 255 30.819 37.447 -2.406 1.00 43.10 C

ATOM 7627 NE ARG G 255 30.168 37.650 -1.109 1.00 47.00 N

ATOM 7628 CZ ARG G 255 29.348 38.659 -0.816 1.00 47.84 C

ATOM 7629 NHl ARG G 255 29.068 39.587 -1.722 1.00 48.73 N

ATOM 7630 NH2 ARG G 255 28.776 38.722 0.379 1.00 49.38 N

ATOM 7631 N PRO G 256 27.844 34.815 -5.537 1.00 31.88 N

ATOM 7632 CA PRO G 256 26.449 34.411 -5.304 1.00 31.34 C

ATOM 7633 C PRO G 256 25.767 35.139 -4.142 1.00 30.86 C

ATOM 7634 o PRO G 256 26.384 35.404 -3.113 1.00 30.32 o

ATOM 7635 CB PRO G 256 26.559 32.906 -5.026 1.00 30.69 C

ATOM 7636 CG PRO G 256 27.860 32.509 -5.643 1.00 30.92 C

ATOM 7637 CD PRO G 256 28.749 33.677 -5.306 1.00 31.69 C

ATOM 7638 N ILE G 257 24.487 35.452 -4.318 1.00 30.45 N

ATOM 7639 CA ILE G 257 23.695 36.120 -3.290 1.00 31.29 C

ATOM 7640 C ILE G 257 22.616 35.161 -2.753 1.00 31.09 C

ATOM 7641 o ILE G 257 21.915 34.514 -3.529 1.00 30.89 o

ATOM 7642 CB ILE G 257 23.023 37.378 -3.880 1.00 33.41 C

ATOM 7643 CGI ILε G 257 24.071 38.488 -4.033 1.00 34.71 C

ATOM 7644 CG2 ILε G 257 21.853 37.830 -3.008 1.00 33.59 C

ATOM 7645 CDl ILε G 257 23.570 39.723 -4.772 1.00 36.23 C

ATOM 7646 N Lεu G 258 22.496 35.044 -1.434 1.00 30.76 N TOM 7647 CA Lεu G 258 21.473 34.171 -0.853 1.00 30.21 C

ATOM 7648 C Lεu G 258 20.361 34.984 -0.214 1.00 30.61 C

ATOM 7649 o LEU G 258 20.577 36.106 0.249 1.00 30.83 o

ATOM 7650 CB LEU G 258 22.045 33.250 0.226 1.00 29.39 C

ATOM 7651 CG LEU G 258 23.313 32.433 0.000 1.00 30.50 C

ATOM 7652 CDl LEU G 258 23.439 31.416 1.128 1.00 29.89 C

ATOM 7653 CD2 LEU G 258 23.274 31.740 -1.323 1.00 31.22 C Table 3

ATOM 7654 N GLN G 259 19.169 34.400 -0.176 1.00 30.63 N

ATOM 7655 CA GLN G 259 18.007 35.044 0.430 1.00 30.35 C

ATOM 7656 C GLN G 259 18.169 35.089 1.957 1.00 29.51 c

ATOM 7657 o GLN G 259 18.481 34.082 2.585 1.00 28.56 o

ATOM 7658 CB GLN G 259 16.742 34.248 0.056 1.00 30.66 c

ATOM 7659 CG GLN G 259 15.410 34.765 0.645 1.00 31.63 c

ATOM 7660 CD GLN G 259 14.201 33.887 0.256 1.00 32.94 c

ATOM 7661 OEl GLN G 259 14.012 33.548 -0.915 1.00 30.95 o

ATOM 7662 NE2 GLN G 259 13.380 33.529 1.245 1.00 32.93 N

ATOM 7663 N ALA G 260 17.941 36.258 2.545 1.00 29.30 N

ATOM 7664 CA ALA G 260 18.036 36.430 3.992 1.00 30.20 C

ATOM 7665 C ALA G 260 17.020 35.540 4.715 1.00 30.29 C

ATOM 7666 o ALA G 260 15.900 35.402 4.261 1.00 30.30 o

ATOM 7667 CB ALA G 260 17.772 37.890 4.344 1.00 29.19 C

ATOM 7668 N GLY G 261 17.410 34.944 5.838 1.00 30.71 N

ATOM 7669 CA GLY G 261 16.485 34.103 6.580 1.00 31.64 C

ATOM 7670 C GLY G 261 16.518 32.621 6.241 1.00 32.25 C

ATOM 7671 o GLY G 261 15.954 31.802 6.970 1.00 32.41 o

ATOM 7672 N LEU G 262 17.179 32.267 5.144 1.00 32.52 N

ATOM 7673 CA LEU G 262 17.267 30.871 4.733 1.00 32.03 C

ATOM 7674 C LEU G 262 18.710 30.396 4.629 1.00 32.97 C

ATOM 7675 o LEU G 262 19.570 31.082 4.067 1.00 32.65 o

ATOM 7676 CB LEU G 262 16.563 30.672 3.387 1.00 31.14 C

ATOM 7677 CG LEU G 262 15.043 30.883 3.387 1.00 31.83 C

ATOM 7678 CDl LEU G 262 14.494 30.812 1.956 1.00 29.95 C

ATOM 7679 CD2 LEU G 262 14.391 29.819 4.274 1.00 30.39 C

ATOM 7680 N PRO G 263 18.996 29.203 5.159 1.00 33.16 N

ATOM 7681 CA PRO G 263 18.042 28.315 5.835 1.00 34.27 C

ATOM 7682 C PRO G 263 17.585 28.826 7.205 1.00 34.96 C

ATOM 7683 o PRO G 263 18.212 29.698 7.802 1.00 35.11 o

ATOM 7684 CB PRO G 263 18.812 26.999 5.920 1.00 33.84 C

ATOM 7685 CG PRO G 263 20.232 27.461 6.068 1.00 33.03 C

ATOM 7686 CD PRO G 263 20.318 28.568 5.048 1.00 33.06 C

ATOM 7687 N ALA G 264 16.480 28.281 7.698 1.00 36.21 N TOM 7688 CA ALA G 264 15.943 28.691 8.989 1.00 37.11 C

ATOM 7689 C ALA G 264 16.253 27.668 10.069 1.00 37.99 C

ATOM 7690 o ALA G 264 16.396 26.480 9.782 1.00 37.70 o

ATOM 7691 CB ALA G 264 14.452 28.878 8.884 1.00 36.73 C

ATOM 7692 N ASN G 265 16.376 28.133 11.308 1.00 38.67 N

ATOM 7693 CA ASN G 265 16.628 27.231 12.420 1.00 39.92 C

ATOM 7694 C ASN G 265 15.461 26.251 12.498 1.00 41.13 c

ATOM 7695 o ASN G 265 14.341 26.565 12.087 1.00 40.63 o

ATOM 7696 CB ASN G 265 16.722 27.992 13.745 1.00 38.98 c

ATOM 7697 CG ASN G 265 17.911 28.931 13.802 1.00 39.26 c

ATOM 7698 ODl ASN G 265 19.043 28.545 13.504 1.00 37.60 o

ATOM 7699 ND2 ASN G 265 17.660 30.173 14.199 1.00 39.35 N

ATOM 7700 N ALA G 266 15.731 25.063 13.019 1.00 42.71 N

ATOM 7701 CA ALA G 266 14.699 24.046 13.150 1.00 44.36 C TOM 7702 C ALA G 266 14.875 23.271 14.449 1.00 45.34 C

ATOM 7703 0 ALA G 266 15.987 23.126 14.966 1.00 45.07 o

ATOM 7704 CB ALA G 266 14.737 23.100 11.955 1.00 44.26 C

ATOM 7705 N sεR G 267 13.760 22.783 14.977 1.00 46.57 N

ATOM 7706 CA SER G 267 13.777 22.033 16.218 1.00 47.52 C

ATOM 7707 C SER G 267 12.839 20.837 16.111 1.00 47.89 C

ATOM 7708 o SER G 267 11.818 20.890 15.416 1.00 47.62 o

ATOM 7709 CB SER G 267 13.355 22.953 17.365 1.00 47.81 C

ATOM 7710 OG SER G 267 13.657 22.380 18.623 1.00 50.08 o

ATOM 7711 N THR G 268 13.187 19.766 16.815 1.00 47.83 N

ATOM 7712 CA THR G 268 12.378 18.555 16.799 1.00 48.09 C

ATOM 7713 C THR G 268 12.770 17.581 17.902 1.00 48.10 C

ATOM 7714 o THR G 268 13.812 17.728 18.546 1.00 48.04 o

ATOM 7715 CB THR G 268 12.498 17.821 15.439 1.00 48.25 C

ATOM 7716 OG1 THR G 268 11.534 16.765 15.384 1.00 49.55 o

ATOM 7717 CG2 THR G 268 13.892 17.228 15.264 1.00 47.43 C

ATOM 7718 N VAL G 269 11.916 16.587 18.117 1.00 48.14 N

ATOM 7719 CA VAL G 269 12.168 15.558 19.117 1.00 47.99 C Tab 3

ATOM 7720 C VAL G 269 12.913 14.430 18.408 1.00 48.08 c

ATOM 7721 o VAL G 269 12.789 14.276 17.191 1.00 47.63 o

ATOM 7722 CB VAL G 269 10.843 15.000 19.699 1.00 48.00 c

ATOM 7723 CGI VAL G 269 10.074 16.103 20.404 1.00 48.03 c

ATOM 7724 CG2 VAL G 269 10.000 14.402 18.590 1.00 47.84 c

ATOM 7725 N VAL G 270 13.692 13.658 19.160 1.00 48.46 N

ATOM 7726 CA VAL G 270 14.439 12.537 18.589 1.00 49.38 C

ATOM 7727 C VAL G 270 13.463 11.695 17.768 1.00 49.64 c

ATOM 7728 o VAL G 270 12.339 11.449 18.205 1.00 49.06 o

ATOM 7729 CB VAL G 270 15.051 11.647 19.703 1.00 49.87 c

ATOM 7730 CGI VAL G 270 15.969 10.597 19.103 1.00 50.47 c

ATOM 7731 CG2 VAL G 270 15.809 12.499 20.683 1.00 50.03 c

ATOM 7732 N GLY G 271 13.883 11.274 16.579 1.00 50.39 N

ATOM 7733 CA GLY G 271 13.014 10.468 15.741 1.00 51.54 C

ATOM 7734 C GLY G 271 12.218 11.253 14.707 1.00 52.36 C

ATOM 7735 o GLY G 271 11.567 10.661 13.843 1.00 53.06 o

ATOM 7736 N GLY G 272 12.269 12.582 14.781 1.00 52.39 N

ATOM 7737 CA GLY G 272 11.535 13.405 13.828 1.00 52.21 C

ATOM 7738 C GLY G 272 12.212 13.623 12.479 1.00 51.67 C

ATOM 7739 o GLY G 272 13.307 13.113 12.227 1.00 51.44 o

ATOM 7740 N ASP G 273 11.544 14.377 11.608 1.00 51.20 N

ATOM 7741 CA ASP G 273 12.050 14.697 10.275 1.00 51.38 C

ATOM 7742 C ASP G 273 12.204 16.219 10.132 1.00 51.14 c

ATOM 7743 o ASP G 273 11.428 16.988 10.708 1.00 51.64 o

ATOM 7744 CB ASP G 273 11.080 14.169 9.213 1.00 51.73 c

ATOM 7745 N VAL G 274 13.193 16.658 9.357 1.00 49.98 N

ATOM 7746 CA VAL G 274 13.422 18.088 9.182 1.00 48.38 C

ATOM 7747 C VAL G 274 14.020 18.447 7.817 1.00 47.58 C

ATOM 7748 o VAL G 274 14.531 17.584 7.098 1.00 47.16 o

ATOM 7749 CB VAL G 274 14.347 18.616 10.319 1.00 48.53 C

ATOM 7750 CGI VAL G 274 15.745 18.033 10.179 1.00 47.61 c

ATOM 7751 CG2 VAL G 274 14.386 20.124 10.309 1.00 49.38 c

ATOM 7752 N GLU G 275 13.936 19.725 7.460 1.00 45.89 N

ATOM 7753 CA GLU G 275 14.483 20.203 6.199 1.00 44.90 c

ATOM 7754 C GLU G 275 15.115 21.587 6.350 1.00 43.37 C

ATOM 7755 o GLU G 275 14.771 22.348 7.256 1.00 42.50 o

ATOM 7756 CB GLU G 275 13.389 20.277 5.133 1.00 45.32 c

ATOM 7757 CG GLU G 275 12.250 21.234 5.466 1.00 46.56 c

ATOM 7758 CD GLU G 275 11.430 21.615 4.237 1.00 47.38 c

ATOM 7759 OEl GLU G 275 11.349 20.793 3.306 1.00 47.81 o

ATOM 7760 OE2 GLU G 275 10.860 22.732 4.204 1.00 47.98 o

ATOM 7761 N PHE G 276 16.045 21.895 5.455 1.00 41.29 N

ATOM 7762 CA PHE G 276 16.721 23.183 5.436 1.00 38.87 C

ATOM 7763 C PHE G 276 16.654 23.656 3.997 1.00 38.05 C

ATOM 7764 o PHE G 276 17.060 22.945 3.082 1.00 36.88 o

ATOM 7765 CB PHE G 276 18.174 23.038 5.889 1.00 37.78 c

ATOM 7766 CG PHE G 276 18.322 22.791 7.361 1.00 37.18 c

ATOM 7767 CDl PHE G 276 17.937 23.761 8.283 1.00 36.53 c

ATOM 7768 CD2 PHE G 276 18.831 21.583 7.830 1.00 37.14 c

ATOM 7769 CEl PHE G 276 18.057 23.531 9.652 1.00 36.90 c

ATOM 7770 CE2 PHE G 276 18.955 21.340 9.201 1.00 36.45 c

ATOM 7771 CZ PHε G 276 18.569 22.312 10.114 1.00 36.22 c

ATOM 7772 N VAL G 277 16.124 24.855 3.806 1.00 36.92 N

ATOM 7773 CA VAL G 277 15.967 25.413 2.482 1.00 36.11 C

ATOM 7774 C VAL G 277 16.952 26.540 2.235 1.00 35.68 C

ATOM 7775 o VAL G 277 17.307 27.287 3.144 1.00 36.03 o

ATOM 7776 CB VAL G 277 14.533 25.961 2.300 1.00 36.01 c

ATOM 7777 CGI VAL G 277 14.322 26.425 0.861 1.00 34.54 c

ATOM 7778 CG2 VAL G 277 13.526 24.890 2.694 1.00 35.65 c

ATOM 7779 N CYS G 278 17.376 26.666 0.989 1.00 35.24 N

ATOM 7780 CA CYS G 278 18.304 27.710 0.605 1.00 35.03 C

ATOM 7781 C CYS G 278 17.871 28.279 -0.743 1.00 34.25 C

ATOM 7782 o CYS G 278 17.392 27.535 -1.596 1.00 34.32 o

ATOM 7783 CB CYS G 278 19.711 27.126 0.499 1.00 34.63 C

ATOM 7784 SG CYS G 278 20.943 28.361 0.107 1.00 37.73 S

ATOM 7785 N LYS G 279 18.032 29.585 -0.934 1.00 33.28 N ouzuuo

ιnnf^ιoo^oι ooo oo<nol co oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

moor'(ΛαιΦo^Hιnolι^,)"»(MdflNOl ιrlp•on(^< lnoιol O ( ^ιnι^,)O ιBOlOH^HOH'» oΦ O)<^ι•»Hlnoιl1^molιn^ι ov ι?lιnιJlO<DlMlnσιιnmHln Φ"l_'Old^^ ιn ι ι<l'(I) |lno)ι^o^<Iι<^ιoι^,)Hf_^ιr-H φ"fN dnrt "l'ln^ Φ^ (M"»(D^c<)>fΦ H HO<MnΦ^(»voo ^"»"^ι)lNΦO)(nln ιιnrod^n_lno OιnΦo«( "»mn o< ιn^ lMΦ( <I>ιnιnHa)(Λ^ι(B"fOHmn^mln M C»ι cM CM rθ 'r ιocD ι ιnvD ι ιn r~ t~ ιococo ιnr~ ι^, r~ nιn oo σi H H Λ cτi H Pθ ro "* ro ι ιn ιn o cM H CM cM H or ro '^

I I I I I I I I I I I I I I I I I I I I I I I I I I I I I H H I I H H H H H H H H H H H H H H HH H H H H H H H I I I I I H I I I I

I I I I I I I I I I I I I I I I I I I I I I I I I I r- o H Φco 5lor• ιJl lIι lr^■ιnlnΦ d roco

oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

M ,_) H HJ rl pi 05 « C-i 05 PS PS pel Z Z Z Z Z Z Z Z Z O O O O O O O co co co co

^, ^, ^ ^ ^ X >H >< H JH 5M X JH H H >ι , (_| H W |_| _] ω c C C CO C0 tO C CO μ- Hl pl J πl Hl Hl pl Hl lllϊ K βϋ- Pli K lU H H H H j j ^ ^ Hq ^ HH t-q H EH EH EH EH H H E^H E^H E^H E^H CO co co co co co rt rt rt rt rt rt rt rt rt PQ D a zυooc υozυoo H CM c ' in cD r- oo cn o H i' τ ' i' "- i ι^, i' ι ιn ιn GO OO OO OO OO OO OO OO CO OO CO r- r~ r~ ι- r- r-- r- r- r-. r- [-~ εoaooaaoaoaoaoεooa aoεoaooεεoaosoaooaaooεεoεoaooaaooaεoaooaεooε < < < < < < < ft ft ft ft ft rt ft ft ft tt ft ft ft ft ft i't rt ft ft ft ft ft

Table 3

ATOM 7852 CB HIS G 287 29.712 25.238 -7.034 1.00 29.44 c

ATOM 7853 CG HIS G 287 29.896 23.844 -6.533 1.00 30.98 c

ATOM 7854 ND1 HIS G 287 30.438 23.563 -5.299 1.00 31.86 N

ATOM 7855 CD2 HIS G 287 29.527 22.652 -7.062 1.00 31.38 c

ATOM 7856 cεi HIS G 287 30.391 22.258 -5.088 1.00 32.41 C

ATOM 7857 N 2 HIS G 287 29.840 21.684 -6.142 1.00 31.49 N

ATOM 7858 N ILE G 288 26.711 24.881 -5.322 1.00 29.94 N

ATOM 7859 CA ILE G 288 26.064 24.781 -4.029 1.00 30.32 C

ATOM 7860 C ILE G 288 26.328 23.478 -3.266 1.00 31.50 C

ATOM 7861 o ILE G 288 26.301 22.385 -3.843 1.00 31.99 o

ATOM 7862 CB ILE G 288 24.545 24.944 -4.230 1.00 29.55 C

ATOM 7863 CGI ILE G 288 24.280 26.221 -5.043 1.00 31.03 C

ATOM 7864 CG2 ILE G 288 23.845 24.967 -2.899 1.00 30.04 C

ATOM 7865 CDl ILE G 288 22.817 26.443 -5.448 1.00 30.30 C

ATOM 7866 N GLN G 289 26.577 23.594 -1.967 1.00 32.07 N

ATOM 7867 CA GLN G 289 26.793 22.420 -1.131 1.00 33.10 C

ATOM 7868 C GLN G 289 26.274 22.691 0.276 1.00 32.96 C

ATOM 7869 o GLN G 289 26.144 23.846 0.688 1.00 32.94 o

ATOM 7870 CB GLN G 289 28.276 22.047 -1.079 1.00 33.70 C

ATOM 7871 CG GLN G 289 29.190 23.136 -0.572 1.00 34.69 C

ATOM 7872 CD GLN G 289 30.652 22.724 -0.607 1.00 35.78 C

ATOM 7873 OEl GLN G 289 31.045 21.754 0.034 1.00 36.22 o

ATOM 7874 Nε2 GLN G 289 31.465 23.461 -1.360 1.00 36.39 N

ATOM 7875 N TRP G 290 25.951 21.618 0.993 1.00 32.34 N

ATOM 7876 CA TRP G 290 25.460 21.719 2.359 1.00 32.63 C

ATOM 7877 C TRP G 290 26.526 21.162 3.292 1.00 34.01 C

ATOM 7878 o TRP G 290 27.037 20.062 3.073 1.00 33.74 o

ATOM 7879 CB TRP G 290 24.157 20.936 2.536 1.00 29.96 C TOM 7880 CG TRP G 290 22.947 21.591 1.917 1.00 27.97 C

ATOM 7881 CDl TRP G 290 22.447 21.367 0.673 1.00 27.32 C

ATOM 7882 CD2 TRP G 290 22.077 22.554 2.533 1.00 26.53 C

ATOM 7883 Nεi TRP G 290 21.313 22.122 0.470 1.00 27.22 N

ATOM 7884 cε2 TRP G 290 21.064 22.862 1.596 1.00 27.22 C

ATOM 7885 CE3 TRP G 290 22.053 23.185 3.783 1.00 25.74 C

ATOM 7886 CZ2 TRP G 290 20.031 23.775 1.873 1.00 25.60 C

ATOM 7887 CZ3 TRP G 290 21.030 24.091 4.057 1.00 26.27 c

ATOM 7888 CH2 TRP G 290 20.032 24.376 3.104 1.00 24.97 c

ATOM 7889 N ILE G 291 26.847 21.921 4.335 1.00 36.02 N

ATOM 7890 CA ILE G 291 27.879 21.533 5.289 1.00 39.06 C

ATOM 7891 C ILE G 291 27.419 21.474 6.745 1.00 40.67 C

ATOM 7892 o ILE G 291 26.645 22.310 7.203 1.00 40.96 o

ATOM 7893 CB ILE G 291 29.065 22.517 5.242 1.00 38.79 c

ATOM 7894 CGI ILE G 291 29.506 22.748 3.796 1.00 40.06 c

ATOM 7895 CG2 ILE G 291 30.209 21.977 6.079 1.00 39.37 c

ATOM 7896 CDl ILE G 291 30.620 23.789 3.648 1.00 40.28 c

ATOM 7897 N LYS G 292 27.920 20.483 7.471 1.00 42.52 N

ATOM 7898 CA LYS G 292 27.612 20.323 8.890 1.00 43.88 c

ATOM 7899 C LYS G 292 28.903 20.642 9.645 1.00 45.12 c

ATOM 7900 o LYS G 292 29.974 20.147 9.278 1.00 44.35 o

ATOM 7901 CB LYS G 292 27.197 18.881 9.184 1.00 44.16 c

ATOM 7902 CG LYS G 292 26.972 18.573 10.669 1.00 44.42 c

ATOM 7903 CD LYS G 292 25.542 18.855 11.097 1.00 44.52 c

ATOM 7904 CE LYS G 292 25.429 19.071 12.610 1.00 44.44 c

ATOM 7905 NZ LYS G 292 25.810 17.882 13.428 1.00 43.93 N

ATOM 7906 N HIS G 293 28.813 21.480 10.672 1.00 46.77 N

ATOM 7907 CA HIS G 293 29.994 21.830 11.452 1.00 49.11 C

ATOM 7908 C HIS G 293 30.218 20.751 12.510 1.00 49.79 C

ATOM 7909 o HIS G 293 29.460 20.639 13.471 1.00 50.32 o

ATOM 7910 CB HIS G 293 29.826 23.207 12.112 1.00 51.00 C

ATOM 7911 CG HIS G 293 29.596 24.320 11.133 1.00 52.88 C

ATOM 7912 ND1 HIS G 293 30.353 25.473 11.123 1.00 53.54 N

ATOM 7913 CD2 HIS G 293 28.680 24.464 10.142 1.00 53.28 C

ATOM 7914 CEl HIS G 293 29.916 26.278 10.169 1.00 54.40 C

ATOM 7915 Nε2 HIS G 293 28.901 25.689 9.559 1.00 54.63 N

ATOM 7916 N VAL G 294 31.249 19.938 12.309 1.00 50.90 N

ATOM 7917 CA VAL G 294 31.557 18.859 13.242 1.00 51.86 C ooouozυooozυooouoυzoooc zoooouuzouououc zuooυooozzυooozoooozuυozoυoo

_{O O}OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ol ιn n

(ηn H ω d ON t σιo) ln

H H H ιnθ 'i' H ~ ι ^,cD cM H H CD CD H OlIι dΦιoω ι oo ωM M lflHo ι»1Mπι^,)ιnιnNιπlπlnln CM rOCMCM Cg CM CM CM CM

^ » _{v v}^ co a!ω(»(» mm iJi miΛiΛΦ (Λooooo dd d d d d M N i <Mi NN< (^,i(^»ι rnιonι ιι^»ιnPi ^ ^ «"f "i' i Λιnι ιnΦΦ r" t" ^ h r- σι σ>σi <Tι σi O OOO O OO O O O OO O H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

CM CM CM CM CM ro co roro i cororo fOco c rocoro cooococo ro co ro rocororn roco co i ro roco ro ro cocofOcococ co

O U . U U U O U U (5 U t3 U O U U O - U U U O OO U U U O l5 IJI , I5 U U O U (3 liI5 U l30 - - OT rt ^•rX_H i Ti Ti Ti 3 J_| J J J J _3 ,_] J J rt < < rt rt 3rtrtrt3rtrtrtrt rtcDUOCDi>l>t;i>ti uoo CQ CoD CoDzrtυooυ CQzortcjoo CQ CuD QuoC-zυrtuo CuQzcrtjoo CυQ CuD CuDzrtoυo CoQ CυJ)υ Q Oυz rtυoo CυQ CoDoQoW Nzzortuou CQzrtucjou CQzrtuooz <cjυo CcjQ ooιΛOHl "l^| ^ OεaOaOOaaOεOεOOεεOOε < < ft ft < < ft

Table 3

ATOM 7984 CGI VAL G 317 26.841 14.078 -14.339 1.00 41.69 c

ATOM 7985 CG2 VAL G 317 28.075 16.226 -14.589 1.00 40.07 c

ATOM 7986 N ASN G 318 25.981 14.296 -10.905 1.00 41.95 N

ATOM 7987 CA ASN G 318 25.189 13.268 -10.248 1.00 44.07 C

ATOM 7988 C ASN G 318 24.232 13.814 -9.187 1.00 44.24 C

ATOM 7989 o ASN G 318 23.456 13.063 -8.608 1.00 45.18 o

ATOM 7990 CB ASN G 318 26.136 12.228 -9.646 1.00 46.50 C

ATOM 7991 CG ASN G 318 27.129 11.694 -10.676 1.00 48.73 C

ATOM 7992 ODl ASN G 318 28.332 11.580 -10.408 1.00 49.64 o

ATOM 7993 ND2 ASN G 318 26.626 11.372 -11.866 1.00 48.81 N

ATOM 7994 N THR G 319 24.290 15.119 -8.939 1.00 43.75 N

ATOM 7995 CA THR G 319 23.417 15.766 -7.959 1.00 42.90 C

ATOM 7996 C THR G 319 23.090 17.152 -8.532 1.00 42.35 C

ATOM 7997 o THR G 319 23.662 18.163 -8.116 1.00 41.85 o

ATOM 7998 CB THR G 319 24.136 15.917 -6.601 1.00 44.24 C

ATOM 7999 OG1 THR G 319 24.688 14.653 -6.211 1.00 45.37 o

ATOM 8000 CG2 THR G 319 23.162 16.379 -5.521 1.00 44.23 C

ATOM 8001 N THR G 320 22.167 17.177 -9.493 1.00 40.79 N

ATOM 8002 CA THR G 320 21.777 18.396 -10.196 1.00 40.16 C

ATOM 8003 C THR G 320 21.215 19.525 -9.339 1.00 39.45 C

ATOM 8004 o THR G 320 20.789 19.319 -8.200 1.00 38.71 o

ATOM 8005 CB THR G 320 20.781 18.091 -11.345 1.00 40.38 C

ATOM 8006 OG1 THR G 320 19.532 17.644 -10.800 1.00 40.05 o

ATOM 8007 CG2 THR G 320 21.348 17.013 -12.262 1.00 40.03 C

ATOM 8008 N ASP G 321 21.229 20.733 -9.905 1.00 38.20 N

ATOM 8009 CA ASP G 321 20.737 21.912 -9.205 1.00 37.69 C

ATOM 8010 C ASP G 321 19.228 21.894 -8.944 1.00 37.99 C

ATOM 8011 o ASP G 321 18.745 22.613 -8.076 1.00 37.70 o

ATOM 8012 CB ASP G 321 21.119 23.181 -9.970 1.00 36.07 C

ATOM 8013 CG ASP G 321 22.612 23.470 -9.941 1.00 35.06 C

ATOM 8014 ODl ASP G 321 23.293 22.992 -9.008 1.00 32.54 o

ATOM 8015 OD2 ASP G 321 23.097 24.187 -10.842 1.00 33.95 o

ATOM 8016 N LYS G 322 18.486 21.072 -9.684 1.00 37.99 N

ATOM 8017 CA LYS G 322 17.039 20.989 -9.514 1.00 37.74 C

ATOM 8018 C LYS G 322 16.623 20.737 -8.065 1.00 37.41 C

ATOM 8019 o LYS G 322 15.651 21.326 -7.578 1.00 36.98 o

ATOM 8020 CB LYS G 322 16.456 19.891 -10.413 1.00 38.14 c

ATOM 8021 N GLU G 323 17.363 19.880 -7.367 1.00 36.92 N

ATOM 8022 CA GLU G 323 17.026 19.562 -5.981 1.00 37.04 C

ATOM 8023 C GLU G 323 18.139 19.831 -4.955 1.00 37.04 C

ATOM 8024 o GLU G 323 18.041 19.395 -3.804 1.00 35.73 o

ATOM 8025 CB GLU G 323 16.584 18.097 -5.879 1.00 37.49 C

ATOM 8026 N ILE G 324 19.175 20.564 -5.359 1.00 36.64 N

ATOM 8027 CA ILE G 324 20.283 20.850 -4.457 1.00 36.36 C

ATOM 8028 C ILE G 324 19.974 21.894 -3.374 1.00 36.39 C

ATOM 8029 o ILE G 324 20.609 21.890 -2.325 1.00 36.32 o

ATOM 8030 CB ILE G 324 21.564 21.298 -5.236 1.00 35.97 C

ATOM 8031 CGI ILE G 324 22.778 21.242 -4.304 1.00 36.15 C

ATOM 8032 CG2 ILE G 324 21.418 22.724 -5.775 1.00 35.04 C

ATOM 8033 CDl ILE G 324 23.201 19.838 -3.928 1.00 35.22 C

ATOM 8034 N GLU G 325 18.995 22.763 -3.610 1.00 36.24 N

ATOM 8035 CA GLU G 325 18.666 23.800 -2.636 1.00 37.40 C

ATOM 8036 C GLU G 325 17.861 23.396 -1.400 1.00 37.97 C

ATOM 8037 o GLU G 325 17.570 24.235 -0.549 1.00 37.80 o

ATOM 8038 CB GLU G 325 17.984 24.965 -3.344 1.00 37.95 C

ATOM 8039 CG GLU G 325 18.949 25.748 -4.228 1.00 39.17 C

ATOM 8040 CD GLU G 325 18.247 26.738 -5.131 1.00 40.30 C

ATOM 8041 OEl GLU G 325 17.453 26.298 -5.998 1.00 40.14 o

ATOM 8042 OE2 GLU G 325 18.488 27.953 -4.972 1.00 40.10 o

ATOM 8043 N VAL G 326 17.496 22.125 -1.292 1.00 38.24 N

ATOM 8044 CA VAL G 326 16.767 21.668 -0.116 1.00 39.31 C

ATOM 8045 C VAL G 326 17.461 20.438 0.460 1.00 39.67 C

ATOM 8046 o VAL G 326 17.779 19.506 -0.270 1.00 39.75 o

ATOM 8047 CB VAL G 326 15.279 21.339 -0.443 1.00 39.91 C

ATOM 8048 CGI VAL G 326 15.188 20.261 -1.530 1.00 40.97 C

ATOM 8049 CG2 VAL G 326 14.573 20.871 0.820 1.00 39.23 C Table 3

ATOM 8050 N Lεu G 327 17.725 20.457 1.763 1.00 40.13 N

ATOM 8051 CA Lεu G 327 18.387 19.341 2.435 1.00 40.28 C

ATOM 8052 C LEU G 327 17.418 18.677 3.397 1.00 41.91 C

ATOM 8053 0 LEU G 327 16.891 19.327 4.306 1.00 41.63 o

ATOM 8054 CB LEU G 327 19.612 19.821 3.219 1.00 39.29 C

ATOM 8055 CG Lεu G 327 20.320 18.778 4.096 1.00 38.07 C

ATOM 8056 CDl Lεu G 327 21.037 17.746 3.225 1.00 36.50 C

ATOM 8057 CD2 LEU G 327 21.315 19.476 5.007 1.00 37.17 C

ATOM 8058 N TYR G 328 17.190 17.382 3.196 1.00 42.74 N

ATOM 8059 CA TYR G 328 16.283 16.622 4.050 1.00 43.93 C

ATOM 8060 C TYR G 328 17.039 15.708 5.022 1.00 45.77 C

ATOM 8061 0 TYR G 328 18.049 15.097 4.664 1.00 45.73 o

ATOM 8062 CB TYR G 328 15.317 15.773 3.196 1.00 41.69 c

ATOM 8063 CG TYR G 328 14.348 16.574 2.342 1.00 39.94 c

ATOM 8064 CDl TYR G 328 14.572 16.760 0.976 1.00 38.82 c

ATOM 8065 CD2 TYR G 328 13.224 17.176 2.910 1.00 39.08 c

ATOM 8066 CEl TYR G 328 13.695 17.531 0.192 1.00 38.26 c

ATOM 8067 CE2 TYR G 328 12.345 17.953 2.144 1.00 38.56 c TOM 8068 CZ TYR G 328 12.585 18.127 0.789 1.00 38.92 c

ATOM 8069 OH TYR G 328 11.731 18.924 0.053 1.00 39.12 o

ATOM 8070 N ILE G 329 16.553 15.635 6.258 1.00 47.90 N

ATOM 8071 CA ILE G 329 17.151 14.768 7.272 1.00 49.82 C

ATOM 8072 C ILE G 329 16.029 14.083 8.047 1.00 51.30 c

ATOM 8073 o ILE G 329 15.304 14.727 8.802 1.00 51.47 o

ATOM 8074 CB ILE G 329 18.032 15.547 8.242 1.00 49.44 c

ATOM 8075 CGI ILE G 329 19.170 16.205 7.472 1.00 48.78 c

ATOM 8076 CG2 ILE G 329 18.581 14.607 9.308 1.00 49.28 c

ATOM 8077 CDl ILE G 329 19.913 17.229 8.276 1.00 50.09 c

ATOM 8078 N ARG G 330 15.891 12.773 7.848 1.00 53.05 N

ATOM 8079 CA ARG G 330 14.836 12.000 8.503 1.00 54.65 C

ATOM 8080 C ARG G 330 15.320 11.157 9.683 1.00 54.87 c

ATOM 8081 o ARG G 330 16.498 10.798 9.773 1.00 54.39 o

ATOM 8082 CB ARG G 330 14.141 11.072 7.495 1.00 56.47 c

ATOM 8083 CG ARG G 330 13.435 11.757 6.328 1.00 58.62 c

ATOM 8084 CD ARG G 330 11.920 11.737 6.477 1.00 59.82 c

ATOM 8085 ARG G 330 11.244 11.856 5.182 1.00 61.36 N

ATOM 8086 CZ ARG G 330 9.944 12.094 5.022 1.00 62.24 C

ATOM 8087 NHl ARG G 330 9.162 12.243 6.078 1.00 62.98 N

ATOM 8088 NH2 ARG G 330 9.424 12.167 3.803 1.00 62.21 N

ATOM 8089 N ASN G 331 14.386 10.840 10.580 1.00 55.35 N

ATOM 8090 CA ASN G 331 14.669 10.035 11.765 1.00 55.98 C

ATOM 8091 C ASN G 331 15.949 10.543 12.431 1.00 56.14 c

ATOM 8092 o ASN G 331 16.923 9.804 12.597 1.00 56.20 o

ATOM 8093 CB ASN G 331 14.798 8.552 11.365 1.00 56.59 c

ATOM 8094 CG ASN G 331 14.834 7.620 12.569 1.00 57.23 c

ATOM 8095 ODl ASN G 331 14.715 8.049 13.717 1.00 57.90 o

ATOM 8096 ND2 ASN G 331 15.000 6.330 12.305 1.00 56.52 N

ATOM 8097 N VAL G 332 15.929 11.814 12.820 1.00 56.01 N

ATOM 8098 CA VAL G 332 17.085 12.451 13.442 1.00 55.69 C

ATOM 8099 C VAL G 332 17.479 11.870 14.793 1.00 55.65 C

ATOM 8100 o VAL G 332 16.636 11.384 15.551 1.00 55.23 o

ATOM 8101 CB VAL G 332 16.853 13.966 13.631 1.00 55.69 c

ATOM 8102 CGI VAL G 332 16.411 14.596 12.318 1.00 55.96 c

ATOM 8103 CG2 VAL G 332 15.820 14.201 14.709 1.00 55.79 c

ATOM 8104 N THR G 333 18.777 11.927 15.078 1.00 55.48 N

ATOM 8105 CA THR G 333 19.331 11.454 16.341 1.00 55.59 C

ATOM 8106 C THR G 333 19.872 12.695 17.044 1.00 55.87 C

ATOM 8107 o THR G 333 19.893 13.777 16.453 1.00 55.99 o

ATOM 8108 CB THR G 333 20.504 10.472 16.126 1.00 55.46 C

ATOM 8109 OG1 THR G 333 21.557 11.134 15.414 1.00 54.62 o

ATOM 8110 CG2 THR G 333 20.050 9.250 15.338 1.00 55.51 c

ATOM 8111 N PHE G 334 20.302 12.550 18.297 1.00 55.79 N

ATOM 8112 CA PHE G 334 20.855 13.689 19.030 1.00 55.65 C

ATOM 8113 C PHE G 334 22.155 14.123 18.356 1.00 55.18 C

ATOM 8114 o PHE G 334 22.590 15.270 18.486 1.00 54.88 o

ATOM 8115 CB PHE G 334 21.172 13.325 20.489 1.00 56.25 C o oooc oozυυoozυυoυυoozuυoυzooozoυouc υoozucjouuoouuuozuuouoozc ooowzooo

oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H i

σι σι

H H

00

© oaaoεoaoaoεoεoεoεaaε

O ooooεoεoεoaoεoεooεoεaoaooεεoεooasoεoεoεooεEoεoεoεoaoaoooooooo it ft < ft < ft ft ft ft ft < ft ft ft ft < < ft ft ft ft ft ft ft < ft ft ft ft

oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H σι n _ eo "J ^ ro ^ N H N Φ H ω ιΛ H O ιn ι w n ^ ol 0 co π ^ σl r- oo H N ι^,) M^, lfl ω l "ϊ ^ r• ol α) ιn n <Jι r• n ι ^ o o r- Φ ) H ιll ^ o ιΛ Φ NΦ ι^,) ^ Φ Φ O N nu o ι<) O H rl Φ Ol » » n w ^ » Φ H n H ι^,) nι»ι (n ^ o oι Φo cι olβι H n n ^ H Φ Λ O ιn ι^,)β(^,) r• O H H ιfι « ΦO O n Φ <Λ * c Φ H O H (M m ω< <^ w <Λ n σl M Φ o H oo ^lι m σl C ^ H l o r■ ιΛ O O Φ Φ lD <! M m oo O H ^ d aι ι^,l ln l H o^ o ^ * ι^l oo H ^ O(»)^^ <l^l

O H CM ro cM ro i "!r cD CD CD oo co r~ c xo> oooo rr-- oooo <cjΛi cσnι <τι oo H H θo oo cD io oo o r-- o co ιι ιi 'r cM H θ θ θ H O H O O O O O H CM CM I' l' rO ' in co in CD 1¹ in I I I I I I I I I I I I I i I I I I I I I I H H I I I I I H I H I I I I I I I I I I I I I I I I I I tn n m ro φ CM -r

c c c r r c r c c c c c coroc r CD O O U O O O CD CJ) CJ) CJ) CJ) O O U O O U CJ) CJ) e⁾ O O U _t _l O _^, O O U U CJ) C) O CJ) 0000 Hωωωw J Hl HS CD H H H H H H H H CΛ CO CO CO W OT C Cll C- ftl C-i e-l Oj CVi eij pH CLl X X

H CM H CM H CM H H CM H H CM H CM

C^Q CD O. ^Q rt C^Q rt < PQ CD ^Q D rt PQ CD rt PQ CD CD Q ft < CQ CD CD _> < PQ 0 < PQ CD Q Q H U N ft c υuυzoooozυuozuooυoozzuuouozcjuououuzuυozυooc uoυzcjoouozc uoc oouooυzo »?

00 rH CO

it rtrtrtrtrtrtrtrtrtrtrtrtrt

Table 3

TOM 8248 C HIS G 353 24.019 29.976 6.266 1.00 33.83 c

ATOM 8249 0 HIS G 353 23.995 28.854 5.745 1.00 33.62 o

ATOM 8250 CB HIS G 353 22.725 31.590 4.887 1.00 31.45 c

ATOM 8251 CG HIS G 353 22.598 32.972 4.314 1.00 31.24 c

ATOM 8252 ND1 HIS G 353 21.390 33.479 3.874 1.00 28.98 N

ATOM 8253 CD2 HIS G 353 23.519 33.939 4.085 1.00 31.47 c

ATOM 8254 CEl HIS G 353 21.575 34.698 3.396 1.00 29.98 c

ATOM 8255 NE2 HIS G 353 22.857 35.003 3.509 1.00 29.58 N

ATOM 8256 N sεR G 354 23.925 30.162 7.582 1.00 34.43 N

ATOM 8257 CA SER G 354 23.841 29.040 8.505 1.00 35.16 C

ATOM 8258 C SER G 354 22.591 29.026 9.371 1.00 36.14 C

ATOM 8259 o SER G 354 21.977 30.058 9.621 1.00 36.56 o

ATOM 8260 CB SER G 354 25.070 29.035 9.407 1.00 35.17 C

ATOM 8261 OG SER G 354 26.245 29.081 8.632 1.00 35.00 o

ATOM 8262 N ALA G 355 22.222 27.834 9.825 1.00 37.15 N

ATOM 8263 CA ALA G 355 21.054 27.658 10.676 1.00 38.86 C

ATOM 8264 C ALA G 355 21.394 26.584 11.695 1.00 39.80 C

ATOM 8265 0 ALA G 355 22.340 25.816 11.513 1.00 39.82 o

ATOM 8266 CB ALA G 355 19.846 27.235 9.843 1.00 37.20 C

ATOM 8267 N TRP G 356 20.626 26.525 12.770 1.00 41.54 N

ATOM 8268 CA TRP G 356 20.881 25.531 13.800 1.00 43.64 C

ATOM 8269 C TRP G 356 19.751 24.523 13.935 1.00 43.65 C

ATOM 8270 o TRP G 356 18.573 24.860 13.788 1.00 43.22 o

ATOM 8271 CB TRP G 356 21.114 26.225 15.141 1.00 46.44 C

ATOM 8272 CG TRP G 356 22.511 26.086 15.662 1.00 49.88 C

ATOM 8273 CDl TRP G 356 23.063 24.983 16.258 1.00 51.44 C

ATOM 8274 CD2 TRP G 356 23.535 27.086 15.640 1.00 51.37 c

ATOM 8275 NEl TRP G 356 24.371 25.238 16.612 1.00 52.49 N

ATOM 8276 CE2 TRP G 356 24.686 26.520 16.244 1.00 52.66 c

ATOM 8277 CE3 TRP G 356 23.595 28.405 15.171 1.00 52.35 c

ATOM 8278 CZ2 TRP G 356 25.884 27.231 16.391 1.00 53.68 c

ATOM 8279 CZ3 TRP G 356 24.785 29.117 15.318 1.00 53.49 c

ATOM 8280 CH2 TRP G 356 25.914 28.526 15.924 1.00 54.51 c

ATOM 8281 N LEU G 357 20.123 23.276 14.191 1.00 43.63 N

ATOM 8282 CA LEU G 357 19.140 22.227 14.387 1.00 44.46 c

ATOM 8283 C LEU G 357 19.162 21.828 15.854 1.00 45.26 C

ATOM 8284 o LEU G 357 20.201 21.426 16.381 1.00 45.00 o

ATOM 8285 CB LEU G 357 19.452 21.003 13.526 1.00 43.98 C

ATOM 8286 CG LEU G 357 18.610 19.760 13.838 1.00 43.52 C

ATOM 8287 CDl LEU G 357 17.133 20.042 13.592 1.00 43.52 c

ATOM 8288 CD2 LEU G 357 19.076 18.604 12.980 1.00 43.08 c

ATOM 8289 N THR G 358 18.017 21.963 16.516 1.00 46.65 N

ATOM 8290 CA THR G 358 17.895 21.582 17.923 1.00 47.93 C

ATOM 8291 C THR G 358 17.109 20.284 18.028 1.00 48.09 C

ATOM 8292 o THR G 358 16.003 20.177 17.499 1.00 48.24 o

ATOM 8293 CB THR G 358 17.159 22.659 18.768 1.00 48.22 C

ATOM 8294 OG1 THR G 358 17.958 23.846 18.850 1.00 48.40 o

ATOM 8295 CG2 THR G 358 16.902 22.140 20.183 1.00 48.34 c

ATOM 8296 N VAL G 359 17.691 19.297 18.703 1.00 48.99 N

ATOM 8297 CA VAL G 359 17.040 17.997 18.889 1.00 50.41 c

ATOM 8298 C VAL G 359 16.756 17.800 20.378 1.00 51.86 C

ATOM 8299 0 VAL G 359 17.685 17.740 21.187 1.00 51.15 o

ATOM 8300 CB VAL G 359 17.931 16.836 18.384 1.00 49.92 C

ATOM 8301 CGI VAL G 359 17.222 15.503 18.595 1.00 49.38 C

ATOM 8302 CG2 VAL G 359 18.246 17.029 16.915 1.00 49.42 C

ATOM 8303 N LEU G 360 15.480 17.688 20.741 1.00 53.56 N

ATOM 8304 CA LEU G 360 15.070 17.535 22.138 1.00 54.99 C

ATOM 8305 C LEU G 360 14.742 16.092 22.563 1.00 56.44 C

ATOM 8306 o LEU G 360 14.593 15.216 21.713 1.00 55.74 o

ATOM 8307 CB LEU G 360 13.838 18.408 22.376 1.00 54.30 C

ATOM 8308 CG LEU G 360 13.939 19.838 21.853 1.00 54.34 C

ATOM 8309 CDl LEU G 360 12.560 20.487 21.838 1.00 53.64 C

ATOM 8310 CD2 LEU G 360 14.903 20.630 22.725 1.00 53.91 C

ATOM 8311 N PRO G 361 14.638 15.837 23.893 1.00 58.35 N

ATOM 8312 CA PRO G 361 14.320 14.519 24.477 1.00 60.10 C

ATOM 8313 C PRO G 361 13.075 13.925 23.790 1.00 61.58 C zooouuυoouuozuuoooooz

oo o ι ι o <M r-. ( co c vo ιι oo ι oo ' θ r_' H H C0 r-- CO 00 O 0000 CM ιnc0O00 CM CM CD ' H 1' H rM CM CN ro cM ^{, , ,} CD ιn vD σι cM 'r co co H σι r- r~ r~

OOOOOOOOOOOOOOOO ooooooooooooooooooooooooooooooooooooooooooooooooo OOOOOOOOOOOOOOOO ooooooooooooooooooooooooooooooooooooooooooooooooo co co ro co cn vo cM O ' oo oo vo in σi σi cΛ oι eo oo o cθ ι~ o cM <M r-- ιn f r~ ro r~ H CM in ιn cθ 'r H θ σι σι co ro ιn "- θ 'r i" θ ιn ιn r~ 'r ro H co ro H CM CM oo r ι~ oo -r -■ t^ ' in H CD oo r σi o i o vD i ro σi o r cD ιn oo '» oo r oo r~ co c (θ CD CM CM ' CM co r~ H r~ τ> H 'r H in r^'H θ '^ [~ H θ Cθ ιn c c_ cfι r θ H ' o o cM CΛ

CΛ CΛ O CΛ H CO σi in H O ' in CM CO rO O o ιn <M H in o co ι< ιn ro co oo ιn t~- H co cM CΛ cτι ιn r~ ^, «o oθ 'r cM n ιn (o o iD cθ H co cM ' σι o cM θ ( H eNi o cM in oo

CM in co i 'r ro ro ro cM m in ' co cD r- -⁾ v nn w (M H θ oi H θ o θM3Mjι mo oi M^ σi m ιn ιn '» ιn ιr "f (i)<M in ιnΦ ιn m ιn (M rt Hw o o o iM)i

CN CM CM CN CN CM CM CM CM CM CM CM CM CM CM CM φ φ φ φ Φ Φ in Φ Φ in ι ιn ιn in >n ιn ιn ιn >n ιn ιn ιn ιn ιn >n > ι ifl ιn ι ιfl ι >n > ιfl ιn κi ι >n iD in ι m « ιι^< r- vD in in H oo H oo m ii H ro o in r- H co cM r~ o cM CΛ io ιι c H r~ co ιn Λ i o m cθ C Oθ r- H -- C CO O H C CM CO H CΛ

-r lⁱ CD CD CM CM H O H CM H H H H CM CM σi cM r- o i oo cM H σi tn o i ii in r c H θo M i "^ '^ co ιn H <Ji ιn 'ϊ" r σι ^ι r^ σι ι^, c oo ι co ι^, iD σι o ιn oo c^ M c ιo σi H σι c i^, cM ^, co σι oθ H in ι σi H CM p- ro i' r- "- O H H ro H H H <Ti oo r- co i 'r <o o ιn "* r~ ^, CM θ ι c r- r~ H "r H D i H r o " in r-- ^, 'r o cM CM CM r- H H σ> 'i ι θ H θ <M H CΛ σι cM i^, ιn r-- H o σi CD in co o o vo m ro m H in o c σι ro ro H oo cM co ιn ro r 'i" o σ) H i 'r ιn cg ι ιn co ro co σι cM ro cM r-- H σ> co σi (θ ι^, "τ CD r~ oo o oD in o fo σι ιn cD r~ ro cM i' i' ' CM H o o cM CΛ oo r- r- oo cn o x> iD iD io vo ιn ι "tf 'r ιo r^ oo oo o3 θ » r r ' H M i c cM C H H '* ι ι co ιn r-- r-- <» ∞ eΛ ri H i co co D in 'r c o cN

H H H H H H H H H H Φ Φ Φ Φ φ r. φ φ ΦΦ Φ Φ Φ Φ Φ Φ Φ Φ Φ r- Φ Φ Φ

H d d N ⁽M CM M i^,) n nι<ι ι»⁾ n n fi H H H H d N M N <M N (M N N N N N n ι n (η ιn w "i^ι « '» « w « ιn ιn ιn ιn iΛ in ιi) ιn ιn ιn ιn ιn ΦΦ Φ cD iD cD co cD CD io cD co cD cD co cD CD VD io iD i i in in i i in in i i i in in in in in in in i i in in in i in in i i in in in i i in in in in in ^

⁽ CO rO C n n rO CO C CO m c CO rO rO CO O H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

CD D CD CD CD CD CD CD CD D D D U CD CD CD D X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X

O O O O rt rt rt rt rt O O O O O O O O CO CO CO CO CO O O CD CD U CD CD CD ca cD CD rt rt rt O O O O O O O Oi p, fύ fH (ύ oi ai (ii Pi Bi eZ Bi m o c a< ai {u aι C ( (li c6 et fZ d 3 rl r & l& <>i C606 ai & lli X Z & c6 6 c6 & 6 c6 c6 Ci C63 (ύ tύ ci cύ cύ oi cύ x x a, ^ θi tu ft < f < < ^ θi at ς aι aι aι c ^ ^ ^ ^ ^ f t t r rt ft fi 't < < ι

H CM H CM H CM H oυ CQ CoD ^Qcjzυ ftcjo CcjQz fcjtuoc CjQ CcjDu^Q ft m ft CQ D Q U CO X X rt CQ CQ CD Q rt OQ CD Q Q Cd W N X ft CQ CD Q Q ω zuuoozououuυzuzzzυuocj zuooocjuzoυouuuuuuoozooocjoυcjz

"l' ιn Φ ^ (D ι^ o H ^ι n « ln Φ m o^o H ( ιη ^ ιn ω o o H ι ι^,1 ^^, ιn Φ _ <J^ o H ( ι ^^, ιn Φ oo <Il o d (M n 'ιι^, ln eo (Il O H (M π <f ιn ID fι H H d H H d < ^l ( ^ι ^ι cM N M (M <M n M n ι ( f n r^ f^ π ^l' '* ^ v ^ "|^| '^' "l' "^ "^ ln l ln ιn ln ln ln ln ιn ι Φ Φ Φ Φ ^ ^ ^ ^ ^ ^

00 ro ( ro ro ro ro c ro ro co co ro co ro (o n co co ro ro co ro r ( c ( co ro co r (θ co co ro ro co co ro ro co ro ro ro o^ rH 0 0000 CX> CO CO 0000 O300 OD 0000 CD 0O 0O O30O CO CO CO CX> 03 CO CO CO CO 0O CO CO CO CO CO 0000 C_ 0D αθ CO CO 00 CO CO O3 CO CO O^

© ssεaa εε aooaaoaoaεaaaaεεaεεεεεεoεε o O O O O O O O Oa EH EH EH EH EH EH EH EoH I-J EHEHEHooooooooooooooo o ft < < < < rt ft t ft ft ft ft ft ft ft < ft ft ft < ft ft ft ft ft ft <t

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

ΦΦ Φ '» •» "f 'f ιn ln-) ι >nL >nιn Φ Φ

H H H H H H H H H H H H xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx

Cⁱ< a< evι P^Lc pH P5 S p5 D4 ή S θ5 Z Z Z Z Z Z Z Z 0- - θ5 tf

0S - « S P5 X X X t o o c co cθ OT CO X X ιj H3 r3 H5 H3 H H H H ι ω t_ ω W W W W W Hl H3 H5 Hq ^■

EH EH EH H H H EH EH EH EH EH EH rt rt rt rt rt rt rt rt EH EH EH H EH EH EH θ O O O ι^ ιJ H3 ιJ H5 ε ε -_ ε _; a 2 S O _ι O O

roror r r r ror c r r c i r c r r c c r c

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH

(M ln n o _d Hr

Nι>

HH

in m co co co co co co co co i ^- i^- [ i^- ^ i - ^ P- ^ ^ [^ _r~ ₍i) ₀₀ (_I> _a) _<x) C σι σι σι σι σι σι o o o o o o o H H H H H M CM CM rM CM r co c c ro c < i' 'r 'r ' 'i^{, ,} ι ι Φ Φ Φ Φ Φ Φ Φ r- r- [~ ^ r• r^■ ^ r- ^ ^ ^ⁱ ^ t~ ^ ^ r. ^ r• r• ^ ^• ^ ^- ^ r^■ ^ ^ ^ ^ p^■ r- ^ ^~ r-

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

H CM H CM H CM H CM H CM

CQ m CD Q Q < C^Q CD ^{Q Q} W W rt P^Q rtcjoo PQυ CDo CDzu ftcjou PQc CDc ^Qjz fυtcjoυ C^Qzc ft

O CJ Z CJ CJ O CJ CJ O O Z CJ O O uozocjzzooouzcj jooo <0zcrtjoou PQ Ouo^Qz^Qzc rtυoυ CQoCDuC zcrt

εoεaaaεεεεaεεaεεεεεaεεεεsaεεεaa Eotιto<oHoHtoιohHooHoHohto<oHHoohohtoιohohoHoHHooEoot toιoHHooHo8H f t < < ft < ft < < ft t ft <

oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

oo dH d dNlM(MMnnnι^,) "l'"f ιDω_ ω_mωω ω ω β ωω _ a)oo H H H H H H H H H H H H H H H H H X X r— I X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X i f^tHft^cxocxocxcxocxowxwxwxxwωωxωxwxωxωxωxoa:caDiO< øΛoc oaiuo:ccDtociufύocύcxocxocxocxoixoxcoocύoXooioιXotχopiocύrt3rt3rtι X X X X X X X X "Z Z Z Z Z Z Z Z

H CM H CM H CM H CM H CM

CQ ID ID ft CQ ft CQ O Q Q ω ω i < PQ CD Q W IS3 X X ft PQ CD rt CQ CD Q ft PQ ft < < PQ O Q Q oouuc zc^jooc^jzc cjocjcjcjcjcjc uzuoouoozozzzc uoucozυuooυuzuc oozυυozυoozc ooυooz r

00 rH aooaooaoaoaoaoεoεoεoεaoaosoεoεooεoεεoεoεooaεososooaaooa §oSoo§§ooε§oεoo§oεoεoεoεoεoεoε «εo«εo«εo«εo.o«ε-o«ε.,_aoιaoεooao „aoo„a

O i ft ft ft ft < ft ft ft ft tt ft ft ft ft ft ft <t fi ft ft < ft ft ft ft ft ft < ft ft < < ft < < < ft ft m m m tf ft et ft m ftm t

uoo

ι^,) m _ n H H H oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H , H H H H - I rl- l l rl rl rl H H H H , H H <ι^, oi Φ ln n CM CM

m m in in m in in vD co iD vov cDDco ιoco r- r~ r~ r- r~ r- r~ oo oooo oo oo oo oo σι σi cΛ CΛ σι σι σι o o o o oo oo oo o H H H H H H H HH H H H H H CM CM CM CM oo oo oo oo oo oo ao oo oo oo ao — CDCo ∞∞os Dco coωcotoai Dco o cDiB CDra co co ωco tD oo iji aiσi σi σiσi mmσiσiσi moiσimm mσi CΛCΛCΛ σi C CΛCΛCΛ CΛ CΛ CΛ

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X

O O O O O O O E^H E^H E^H E^H E^H E^H E^H EH O O O O O O O ^ βi tf K tf lll tf Ei i H H Ei υ U U U O U U U - U U b C- b Oi lH Pi Pi αiαi b Pi Pi b αi DD O ι_ oi Λ cc; c_ o; o5 ω ω _ι ω i-i ω w ω o. c- c_ o- c_ α£ pέ ω ω ω ω u u ω ω £ £ ρέ X X X pϋ pύ X p4 ύ έ £ cέ fi oϋ tf (-ι θι θι i-ι i-ι cu -ι ε a a a a a a a cκ - PH CH C-1 ^ 0< EH EH EH EH EH H a 2 ε a 2 a rt rt rt rt rt rt rt rt rt rt rt EH EH EH EH H EH EH H H EH H H H H H^ Hj Hq p1

H CM H CM H CM H CM COCM CO CM z o a, o o CQ CD ^Q ft CQ CD Q ω ft CQ C CDD QQ fftt PPQQ OO CCDD fftt PPQQ CCDD QQ WW ft CQ CD Q W N X X rt PQ CD Q Q ω ω ω cO N X t o u u z u u o u u oi u z uuo u u υ uo zz uυ uυ oo uu oo uυ zz uo uo oo uυ uυ rac uu z o υ o o o o z u z z z υ u o u υ υ o z ϋ o o υ o z c o o

© oaεooεoεosoεεoεooεoεεoεoεoεooεεooεoεεoεooεoεaooaaoaooa S oS o oS S oE o o ft ft < < ft ft < < ft < < ft ft < ft < < < ft < ft ft < £ ft & ft ft & ft & ft

CO oυυuzυoououuzzcjuoouozzooozυυoυzυυoυzυυooυoouυυzoυoυzυυoυoυozzυυoυcj ro C δ! ©

H υ ιΛ Φ ^ n ^ lD "f "^ O O H ^ σι ^ι O (^,1 v ^ Λ ^ O (0 <ι^l ^ <^ ιΛ ^- ι^,l "l^, ^• ^ι o o H ιn H σι d (^ N (^ o ι^,l ln <Jl ^ l d ^ (M ^l fl0 ι0 00 cι n ^ ιη a. H ^ ιo n N ι^ N n n H ιn (^ » » v Φ N N N O « o Φ ( OO '» Φ ^ ln ι m ^ι n ι v o o ιn σι (» (M ^ ^ n o w w « flO NO n o » ^βι ^ ^β o ^ (^,) Φ ι ^ ('l H cM n n N H H N N θ H ( H w v ιn "i^, ιn ^ h oo ιθ ιn ^ Φ Φ Φ Φ Φ r~ ^ Φ ^ ^ o ω Φ Φ Φ ^ ^ oo ω oo ι^ m ω _ σι m r- rⁱ ^ ^ ^ oι w w αi H ^ c c co c ro c c fo c co c co ro co ro ro co c ro co ro co ro co co ro co co co ro fo co c co co co fo c co co co co co co m oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

^ι o N ι_ o H ^ m o M (M ι oιn ^ o "f oo ω Φ π ω n Φ ffl ω o^ ^ ω c ^•» ιΛ o ^ N N O o <n n ιn β^ ιn n Φ c- ιn ln ιD M ιn ^ι n H Φ H π ω (M M v o o ι w ιη π d O "r d <D ι lΛ^l Λ c^ι o (M (M ιn H Φ d M m ( ln H Φ O ιn ιn » (M O ln ιn ol r• 'r d ln ιn ι«ι Φ H <M ιnι^,^ o < Φαι H ^ σl n n ιη ln ω ιM o u) « <Λ (M H ^ ιn ln n n ιn ^ ^ _ "f eo al co d ^M (Jl m ιn c! m ιn H O O o) ^ Φ H ^ ^ ( o ^ o ol Φ 'r Φ a) Φ n n Φ

H ι^, <f ι^ (D ^ ^ ιn (^,l<M H ^ ^ ol m Φιnln » O d d ι o o o ι⁾l Ol o o o ι^) O I- ^ ^ ^ ^ Φ lO "l^ι nn ιn "l^l f) m ^^, (^,) H Oι^,l nι^,) <M « H 005>O H "- «τ i" ' r ro co co co co co co co <o co ( ro co co ro r 'r ι ι "* "- ro o "? co r "- i c co co co co ro to ro ιo ro ro m oo co cD i^ι r~ cD in H co co co o ιn < H co o σι ιn c^ 'r ιn ιn H CM θ co cΛ oo ^, θ H H H co cx> o^ c_ o ιn ι-- H θ3 co ιn oo r- r~ oo cM θ cD ιn OO O CO I' P- l H lO O VD O CO O ιn < H i~ ^, r^ ')^, _' _' '» co ro ιn r~ CM M in σι σι r~ o <ι> ιn c H r~ oo ιn ιn H H ι~ H H oo ιn o 'r cM θ co ro c_ σi H r H CM CM co ^, r ■~ - σι r~ co H θ ro H ro cM σι ιn oo ιn

CM C0 ιn r- CM θ r- O CM H C0 CO CD O 00 CO O lD CM r0 C0 H [~ r0 O '> O 001" H H H O O ιn θ O ιn H CM O C0 H r000 ιn θ 1' ιn C0 H CD 0o0o cD H CM in r- co H H O in ro σi m o

H O H O H CM CM CM H CM H CM H Iⁱ lⁱ l l' ' m iO l l' rO CM CM H O O O O CM CO rO C n ro ι m cM CM H CM H H H in cD CD ιn t-~ r~ r~ r~ r- <τι σι oo oo oo ao oo co cD oo oo ro I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

Λ σι n oo oo '» c^l N ⁽Il oo lnoo ιn ^ ⁽D ιΛ O d ln "l^, o n ιJl O N ^ "^ O ω n ιn Λ « o o m β o ιn "ι' ln ι H ll^l "l^l H oo(- ω <l^ι <ι o oo ιn ^ (^,) ι n Φ H n O H H CM CM ιn o oo < H t~ r~ < ι o <o c^ι ιn ι~ oo c ιo σι c_ c ι O 'r 01¹ CM ι 'I' ιχl > ιn H r oo H H ι cD < M CD ιn ^O H lO H O CD M H r~ co ι^ oo eΛ ι~ CM H H ^ •

^ ιfl oo <Il (M O ^ O ^ ι^n^ "» ^ ιn ιn H ^ o w co n lM ι^,l π o ( N ^ ^ Ol ln aι O) "lι ^ Φ ι») CM ι H ι^,1 H O Ooo ln ^- ι^ι d ι») ιn ι)l d » Φ d "^ ι^ι c

N l d d N lM o m ιM H H d d o m x ^ ω <^l ι^ ι^ o^ » ^o ^ flo ω ln o ^ o^ o o σl aι N < ⁽^ (^ 1» ln n H» lO < (M n n H P1 fl n » L^l r^■ r^■ o (^ι d d o o ιJl ι ιn ι ιn ι ι ιn ι^ι ι ι ι ι ι ιn "^ 'r * ' ^, ' iⁱ "^ 'r ιι ^ι '3" i 'r i' i ι ^, ιn ιn ιn ι ι ιθ ι ι ιn ιn ι ι ι ιn ι ι ιn ιn ιn ι ι ^

N CM (\ w n <η n ⁽η n n n n ιη «» "r ^ «» "f ^ "» v ιn ιn ιn ιn Φ Φ ι^ ^ ^ r~ oι ω ω ω eo a) co ω oo ω co σι fι σι σι m o o o o o o O oO O O H H H H H H c^ cΛ <τι ^ σι σι cxι <τ* cΛ ixι <Λ σι σι σι aι σι σ σι ιx» <τι σι cΛ CΛ ^ <Λ <Λ <τι <^ cΛ <yι <jι σι σ σι σv σι σι σι σι σι σι <yι <τι Λ <Λ σι ^ cΛ O O O O O O O O

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H Og CM CM CM CM CM CM CM CM CM CM CM CM CN CM

X XX X X x a x x x x xx x x xXX X X X X X X X X XXX X X XX X XX X X X X X XXX X XXX X X X X X X XXX X X X X X X KBri a!

DDDDcowcoc cocococ cozzzzzzzz>H>H 4>HwcowwwDDDDDωωωωωωωωωωωc MocCoQwCOcoO CO Z Z Z Z Z Z Z Z Z D D D D D D aaaaxxxxxxxxxmmtn'nuimtntn^^^^xxxxx^^^ t rΑ x xxx xxx xxxx ^ ^ rl ^ ^ ιl ^ ^ r1 ^ tt tt < O ιl *l l ^ m Ch ι P P* ( C (l, ( 0i aι l >l ^ l

Table 3

ATOM 8710 CD GLU H 201 49.234 ,456 32.888 00 46.42 C TOM 8711 OEl GLU H 201 50.276 .701 33.541 00 47.29 0

ATOM 8712 OE2 GLU H 201 48.105 .916 33.189 00 47.42 0

ATOM 8713 N HIS H 202 51.465 .656 31.236 00 39.09 N

ATOM 8714 CA HIS H 202 51.015 .281 31.060 00 38.39 C

ATOM 8715 C HIS H 202 51.687 .527 29.901 00 37.42 C

ATOM 8716 o HIS H 202 51.258 .427 29.541 00 36.70 O

ATOM 8717 CB HIS H 202 51.164 .515 32.376 1.00 40.07 C

ATOM 8718 CG HIS H 202 50.119 ,863 33.391 00 42.25 C

ATOM 8719 ND1 HIS H 202 48.978 ,575 33.072 00 41.73 N

ATOM 8720 CD2 HIS H 202 50.017 ,563 34.709 00 42.67 C

ATOM 8721 CEl HIS H 202 48.222 ,695 34.148 00 42.51 C

ATOM 8722 NE2 HIS H 202 48.827 ,090 35.155 00 43.17 N

ATOM 8723 N ARG H 203 52.731 .120 29.315 00 36.47 N

ATOM 8724 CA ARG H 203 53.429 .508 28.169 00 35.54 C

ATOM 8725 C ARG H 203 54.157 ,563 27.339 00 35.60 C

ATOM 8726 o ARG H 203 54.540 ,614 27.850 00 35.55 O

ATOM 8727 CB ARG H 203 54.445 -2.438 28.617 1.00 34.59 C

ATOM 8728 CG ARG H 203 55.832 -2.971 29.006 1.00 33.37 C

ATOM 8729 CD ARG H 203 56.737 -1.854 29.562 1.00 32.84 C TOM 8730 NE ARG H 203 57.270 -0.955 28.533 1.00 30.57 N

ATOM 8731 CZ ARG H 203 58.413 -1.159 27.882 00 29.72 C

ATOM 8732 NHl ARG H 203 59.147 -2.234 28.150 00 29.07 N

ATOM 8733 NH2 ARG H 203 58.829 -0.285 26.973 00 29.38 N

ATOM 8734 N ILE H 204 54.345 -4.284 26.054 00 35.87 N

ATOM 8735 CA ILE H 204 55.050 -5.221 25.181 00 37.45 C

ATOM 8736 C ILE H 204 56.449 -5.450 25.769 00 37.69 C

ATOM 8737 o ILE H 204 57.172 -4.492 26.053 00 37.77 O

ATOM 8738 CB ILE H 204 55.232 -4.654 23.741 1.00 38.36 C

ATOM 8739 CGI ILE H 204 53.878 -4.332 23.099 1.00 39.88 C

ATOM 8740 CG2 ILε H 204 55.968 -5.673 22.876 00 39.29 C

ATOM 8741 CDl ILε H 204 53.061 -5.548 22.712 00 40.07 C

ATOM 8742 N GLY H 205 56.824 -6.709 25.958 00 37.43 N

ATOM 8743 CA GLY H 205 58.138 -7.011 26.500 00 37.45 C

ATOM 8744 C GLY H 205 58.290 -6.855 28.002 00 37.05 C

ATOM 8745 o GLY H 205 59.377 -7.089 28.538 00 37.32 O

ATOM 8746 N GLY H 206 57.217 -6.456 28.683 00 36.41 N

ATOM 8747 CA GLY H 206 57.271 -6.298 30.129 00 35.85 C

ATOM 8748 C GLY H 206 58.381 -5.406 30.661 00 35.30 C

ATOM 8749 o GLY H 206 58.754 -4.416 30.034 00 34.59 O

ATOM 8750 N TYR H 207 58.907 -5.757 31.830 00 36.01 N

ATOM 8751 CA TYR H 207 59.967 -4.974 32.448 00 36.69 C

ATOM 8752 C TYR H 207 60.936 -5.836 33.257 00 36.92 C

ATOM 8753 o TYR H 207 60.720 -7.037 33.437 00 35.87 O

ATOM 8754 CB TYR H 207 59.362 -3.901 33.352 00 37.45 C

ATOM 8755 CG TYR H 207 58.487 -4.456 34.449 1.00 38.55 C

ATOM 8756 CDl TYR H 207 57.111 -4.617 34.267 1.00 38.56 C

ATOM 8757 CD2 TYR H 207 59.040 -4.837 35.673 .00 39.04 C

ATOM 8758 CEl TYR H 207 56.302 -5.144 35.289 ,00 39.03 C

ATOM 8759 CE2 TYR H 207 58.253 -5.367 36.692 .00 39.41 C

ATOM 8760 CZ TYR H 207 56.886 -5.518 36.499 ,00 40.67 C

ATOM 8761 OH TYR H 207 56.119 -6.041 37.523 ,00 41.90 o

ATOM 8762 N LYS H 208 62.005 -5.210 33.744 ,00 36.64 N

ATOM 8763 CA LYS H 208 62.998 -5.917 34.533 ,00 37.93 C

ATOM 8764 C LYS H 208 63.275 -5.173 35.839 ,00 38.82 C

ATOM 8765 o LYS H 208 63.281 -3.942 35.879 ,00 38.86 O

ATOM 8766 CB LYS H 208 64.296 -6.076 33.729 ,00 37.63 C

ATOM 8767 CG LYS H 208 64.115 -6.787 32.381 ,00 37.50 C

ATOM 8768 CD LYS H 208 65.439 -6.901 31.637 ,00 35.87 C

ATOM 8769 CE LYS H 208 65.296 -7.633 30.323 ,00 34.97 C

ATOM 8770 NZ LYS H 208 66.601 -7.668 29.613 ,00 35.16 N

ATOM 8771 N VAL H 209 63.499 -5.931 36.906 ,00 40.16 N

ATOM 8772 CA VAL H 209 63.782 -5.357 38.218 ,00 42.42 C

ATOM 8773 C VAL H 209 65.049 -5.964 38.793 ,00 43.29 C

ATOM 8774 o VAL H 209 65.201 -7.181 38.817 00 44.11 O

ATOM 8775 CB VAL H 209 62.623 -5.625 39.221 00 42.75 C

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

HHHHHH I H H H H H H ,

Φtiι m d v O ιnn d m ιn in * i in i ro

I I I I I

σi σiO OOOO H H H H H CM CM CM¹

OOHHHHHHHHHHHHHn

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM d d u u u u u z zi a g z g a z K e n w n tn oi ra ra ra Ki io ui Hi w n i- Bi i- iii Pi in Mi iii Bi iii rt Λ ώ l5 l5 ώ ll)tO O⁾ Oi J ^j Hl ) | H H H H H H H H H H (i; (ι; il! (. a; ti; i. B; (i |]li lli lli « (li > > rt rt rt rt rt rt rt rt rt rt -l -^, D _i O a EH EH H EH EH EH H EH EH H EH EH H eH

H CM H CM H CM H CM H CM rO CM CO CM H CM H CM H cD < m t m ft Q < m o a a ω ω ft CQ Q Q W M W N N W < CQ CD tt PQ CD Q Q ft PQ CD CD Q ft oozoυoozc uoυzυuoυzcjυooozcjυzzoooυυoozcjooucjzuoouozououoυuzoυooυυuzuo

aooεoaaaaaεaεaaaEsεaaoaoaooaEooEεogooaoa H h 8< H h h ooooooooo ft ft ft

oucjcoozcjυouucjoozc cjooozucjouuuzouoooozυυoooozoυooozouooooozυuooooυzzυ

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO _OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

o al r• ι Φ o o ι»ldι^,) ln n ιΛdln o M

<τι j

oo∞aιooro(iισι<jισισιmσιoιo\ooooood HddHHi N<M<MNNNiηι»)nιornrori"f "i^|"i^,^^ι«9iιiιnιnιnιnιnιnιn Φ ΦΦΦΦ r'

H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CMCM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM W

X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X OOOOO O t.OlΛ ΛΛlϊMli Ili Cμ . iiMl) o c cococo co co coco X X U U a U M hl J J J J J J J J M U H W W Iil n; r r rt .,rt.,rt.,rt.,K..P„ήp„cJ o„i p„- pS Pβ M wi-i i-i w wcococo co w co w co x xxxxxxxx ε ε 2 2 ε cD CD CD CD CD CD O CJ) D c0 W C0 C0 C0 C0 > II JJJ J J J JJJ J O rt >rt >t >t > >rt .rt

> > > > > CH C_ EM θ- o< i4 C_ w o o o co rt rt rt rt rt rt rt rt Hi H i H^ H3 H3 H3 J pi

H CM H CM mc3aωω f PQ O tt CQ CD O ft CQ CD CD < CQ CD Q < CQ O t CQ CD Q Q ft CQ D Q W N < ouucoozυoououo - ozuc ouozc uoooυzouo υυozυuoooozuoooozoooϋυoozoυoυoouzzu

oo rH a aε o ooaooaoaooaaoaooaaaaaaaεεεaaεaaaaaaεεεεεεεεaaεεεεΞεεεsεεεεεεεaaεεεεεaaaaa

EH h HE< hB H EH H hohoBHooHEoHoHo£H HoohHooEιoEιoHhoot<ohoHooEHoHohoHHoooHtoH BoohhooH toι BoHooHoHohEoιoHoιoHoEιoι HooHohoE otιoEHo^oEHoEHotιtoιot<otHtoι it ft ft tt ft tt ft ft ft < < ft tt tC < ft < < < tt tt tt <ft < tt tt ft tt tt tt < < tt ft ft ^

TabU 3

ATOM 8908 C GLY H 227 53 . 187 7 . 849 34 . 509 1 . 00 31 . 81 c

ATOM 8909 o GLY H 227 54, .310 8.355 34, .435 1, ,00 31. .79 o

ATOM 8910 N ASN H 228 52, .646 7.447 35. .655 1, .00 31. .03 N

ATOM 8911 CA ASN H 228 53 .354 7.550 36. .921 1. .00 30. .85 C

ATOM 8912 C ASN H 228 53 .845 6.187 37. .376 1. .00 29, .72 C

ATOM 8913 o ASN H 228 53 .123 5.191 37. .279 1, .00 30, ,39 O

ATOM 8914 CB ASN H 228 52, .454 8.138 38. .002 1, ,00 32. .32 C

ATOM 8915 CG ASN H 228 52. .044 9.561 37. .700 1, ,00 34, .94 C

ATOM 8916 ODl ASN H 228 52. .877 10.394 37, .331 1, ,00 35, .94 O

ATOM 8917 ND2 ASN H 228 50. .757 9.853 37, .855 1, ,00 35, .31 N

ATOM 8918 N TYR H 229 55, .080 6.155 37, .866 1, .00 27. .72 N

ATOM 8919 CA TYR H 229 55, .689 4.928 38. .362 1, .00 27, .25 C

ATOM 8920 C TYR H 229 56, .153 5.166 39, .799 1, .00 27. .25 C

ATOM 8921 o TYR H 229 57, .006 6.020 40, .061 1, .00 26, ,34 O

ATOM 8922 CB TYR H 229 56, .846 4.512 37, .447 1. .00 26, ,74 C

ATOM 8923 CG TYR H 229 56, .372 4.151 36, .054 1. .00 26, .75 C

ATOM 8924 CDl TYR H 229 56. .148 5.131 35. .081 1, ,00 26. ,36 C

ATOM 8925 CD2 TYR H 229 56. .083 2.830 35. .725 1, ,00 26. ,67 c

ATOM 8926 cεi TYR H 229 55. .645 4.793 33. ,817 1, ,00 25. ,79 c

ATOM 8927 cε2 TYR H 229 55. .584 2.488 34. .474 1, ,00 25. ,91 c

ATOM 8928 CZ TYR H 229 55, .368 3.464 33. .528 1, .00 26. .33 c

ATOM 8929 OH TYR H 229 54, .882 3.082 32. .287 1. .00 27, .87 o

ATOM 8930 N THR H 230 55, .568 4.405 40. .722 1. .00 26, ,69 N

ATOM 8931 CA THR H 230 55, .852 4.537 42, .145 1, ,00 26, .63 C

ATOM 8932 C THR H 230 56, .543 3.338 42, .766 1, .00 26, .70 C

ATOM 8933 o THR H 230 56, .150 2.194 42. .548 1, .00 26. .96 o

ATOM 8934 CB THR H 230 54, .550 4.774 42. .930 1, ,00 27. ,14 C

ATOM 8935 OG1 THR H 230 53, .916 5.970 42, ,454 1. .00 28. ,26 o

ATOM 8936 CG2 THR H 230 54, .834 4.896 44, .425 1. .00 27. .42 c

ATOM 8937 N CYS H 231 57, .568 3.611 43, .562 1. .00 27. ,11 N

ATOM 8938 CA CYS H 231 58, .291 2.547 44. .247 1. ,00 27, ,77 C

ATOM 8939 C CYS H 231 57. .852 2.567 45. .713 1. .00 27, ,56 C

ATOM 8940 o CYS H 231 57. .845 3.617 46. .344 1. .00 26, .94 o

ATOM 8941 CB CYS H 231 59, .803 2.791 44. .160 1. .00 28, .81 C

ATOM 8942 SG CYS H 231 60, .369 4.264 45. .054 1, .00 29, ,74 s

ATOM 8943 N VAL H 232 57, .464 1.405 46. .234 1, .00 29, .02 N

ATOM 8944 CA VAL H 232 57. .048 1.257 47. .632 1. .00 30. .32 C

ATOM 8945 C VAL H 232 58, ,065 0.337 48. .328 1. .00 31, ,10 C

ATOM 8946 o VAL H 232 58. .294 -0.792 47. .888 1. .00 30, ,52 o

ATOM 8947 CB VAL H 232 55, ,634 0.617 47. .747 1, .00 30, .65 c

ATOM 8948 CGI VAL H 232 55. .164 0.652 49, .189 1, .00 29. .14 c

ATOM 8949 CG2 VAL H 232 54. .644 1.368 46, .855 1. .00 30. .28 c

ATOM 8950 N VAL H 233 58. ,664 0.822 49. .415 1, .00 31. .38 N

ATOM 8951 CA VAL H 233 59. .678 0.057 50, .131 1, .00 32. .74 C

ATOM 8952 C VAL H 233 59. .271 -0.123 51, .583 1, .00 33. .12 C

ATOM 8953 o VAL H 233 58. .919 0.846 52, .253 1, .00 34. .28 o

ATOM 8954 CB VAL H 233 61, ,044 0.775 50. .016 1. .00 32. ,49 C

ATOM 8955 CGI VAL H 233 62. ,095 0.072 50. .830 1. .00 33. ,55 C

ATOM 8956 CG2 VAL H 233 61. ,462 0.815 48. .550 1. .00 32. ,77 c TOM 8957 N GLU H 234 59. ,322 -1.354 52. .082 1, .00 33. ,62 N

ATOM 8958 CA GLU H 234 58. .884 -1.588 53, .453 1. .00 34. ,62 C

ATOM 8959 C GLU H 234 59. .435 -2.781 54, .233 1, .00 33. .75 C

ATOM 8960 o GLU H 234 59. ,942 -3.754 53. .671 1, .00 33. .82 o

ATOM 8961 CB GLU H 234 57. ,358 -1.656 53. .465 1, .00 36. .46 C

ATOM 8962 CG GLU H 234 56. .794 -2.727 52. .553 1, .00 39. .69 C

ATOM 8963 CD GLU H 234 55. .327 -2.489 52. .180 1, .00 43. .48 C

ATOM 8964 oεi GLU H 234 54. ,753 -3.359 51. .485 1. .00 43. ,83 o

ATOM 8965 oε2 GLU H 234 54. ,751 -1.436 52. .564 1. .00 43, ,30 o

ATOM 8966 N ASN H 235 59. ,337 -2.660 55. .554 1. .00 33, ,27 N

ATOM 8967 CA ASN H 235 59. ,739 -3.701 56. .500 1. .00 33, ,61 C

ATOM 8968 C ASN H 235 58. .806 -3.533 57, .700 1. .00 33, ,99 C

ATOM 8969 o ASN H 235 57. .882 -2.713 57. .655 1, .00 33, .48 o

ATOM 8970 CB ASN H 235 61. .225 -3.584 56. .917 1, .00 32. .09 c

ATOM 8971 CG ASN H 235 61. .535 -2.342 57, .754 1, .00 31. .97 c

ATOM 8972 ODl ASN H 235 60. ,664 -1.759 58, .388 1. .00 31. .33 o

ATOM 8973 ND2 ASN H 235 62. ,807 -1.961 57, .780 1, .00 31. .28 N φ φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ OO oo oo oo oo Go oo oo co D O co co co co φ co oo αs ω Φ i co o oo )

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O IO VD CD CD CD IO CD O VD CD ID IO CD CD CD ID CD ID ID IO CD IO CD ID ID CO ω ω ω ω ω ω ω ω ω ω NJ J i- M M M i i- i- j H^H r^H H^ HH M H^H H^H p^j p^j H^H O o o o o o o o o o io io ω o -i iD co iD c^ _ . -J θ ^ αι uι '> U M P θ - ~i i)ι uι <ι Cιi M θ Φ θθ vi m uι » ω iι) P θ Φ i⁾⁾ "J θ\ ui ω ι p o Φ αα M βι ui ι& ω N⁾ θ - M Φ π » U N θ ID CO -J CΛ H !—• onoopzoooooozzoozoooπozzoonooozooooooozooooozooozoooooooooooz oc > o a a > wpiαocnω > αootd > oootβ > Ω to > > X N PI M O O O CD f o tO l- H-" P M P W P M P to o o > n z

xaaaaaaaxaaaaxaaaxaaxaaaaxaxBaaaxaaaaaaaxaaaaaaxaaxxxaaxxaaxaxaaax h) M M N) M M M M N I KJ M ) M N M I ] M K) N N) NI K! |v) Nl Nl l N N M M K> NI M N Il) M N M N U M M M N N) KJ N N) N N

^ ^ ^ & ι_ ^ fr ^ A ^ ι- fr ^ ^ ^ fr & ft ι- ^ ^ A ^ ^ ι- A & ^ ^ fr ^ ^ ^ ft fr ^ ^ & ω ω (Ai u ω u } ω ι ω u ) ω ω ω u [ιi u ω iι} u tιt } ω tιJ u ω ι_. ιi_ ι_. ι_. Λ ι-. _ C_ ω w ω C_ _ 3 M N3 M ^ J M IVJ M r l-> l-^H _r ^J r^H |-> l-' l-' t^H O O O O O O O θ ω

σι ι ι/> c^ ι (/ι jι (^ ^ ι^ c^ uι c^ σι σι σi τι cΛ σι uι uι υι oι ^ ^ c^ c/ι uι uι /ι ^ Λ Cjι Λ ^ υι c^ ι^ θ Φ m J CD J ιi> Λ θi α) M ijι M p o o o M >^j flθ flθ Λ Λ ft W J ^{j j} i p θ Φflθ J M M W uιm m m 5i i- ^ ι α) M i o iι θ M θ θ oo oo φ α) i (» ω φ φ A ω u ω o ι o o p o θ9 N) _ o (D ιr φ .j φ ω sι ) o uι p uι uι μ ιιι α_ ω oo ω

Ol Ki M O 00 ω ω ω ω ω _ _ ι-^ ι-, ι-, ι-> -, ι-' i-. ι-^ ι-. ι-, ι-. -> ι-. ι-- ιb ι& -> ι<^ ι-. ι-^ ι-. ιl- -> ι-> ι^ ω ι i (D θ P iJ ) P P N) (r U ^ ω ui fr uι i Ui ^ φ m Φ Φ M _ o f ^ N}|ι) θ o ι N)r A> A (Λ) ώ ^ ^ m oo (θ ώ ^ tvj Cι} i4 [v) P θ θ P θ θ P θ _

M fc αi φ O M * ft U A M N IJ Ul M 0] m ω M 01 O M ~l P Ul φ lJl O Λ P P 0l N J M l. ft Φ UI O σi Φ M O * 00 M P t J lJlN P * Φ ω ffι ~l 01 fc ^ O J ^ lD φ lJ O W M W H U W P UI α) l O J U Iιl O) H O O\ _'J O P * l!l 'J ft Λ lιl l "l J ilI15i πi CD W "1 l t ON O * 05l tl) 5l UI (>I Λ U10! Φ P UI Φ P (? M M O U UI N ()l (. Φ P IB Oi m ft UI (O M Φ A P Λ O O> Φ Λ P α⁾ ft 10 ^ 0 H "J Φ O U M O U10W UI * U UI J U UI βl lι⁾ M - -J J P *

H H P H P I l-> I-¹ p» HH HM pμppHPHPpμpp

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O lΛ) _ _ _ _ l- M

W M ω u M J

Oθ m (^ N P O M M O jfc CI) M N *

CΛ θ _ p o ^ ιi Λ -j J ijι ι)

ooooozoooooozzoozooooozzoooooozoπooooozooooozooozooonooooooozooooz

oc ou

O Φ d d ΦΦΦ _ oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooσoo

«■*Hι^,)^(MιflO'*nmd(oιnΦddιnoι^,)^'l• «o 9ddom!M r-ΦΦ^ιnϊι( t^f)Of■omιn^nd( nlnNOOιnι- ι»1ιf)0)ιnr•ι»)ι φ ιolnnιn l_Mn ' "l^ι^ lno ^oHιnNΦ N^lOO OOlffln lHlI^HO"»Mω l(^ldHΦln^^<)^lDt "l^l^<MNΦ ldσlNln"l'^N!^ι ^ ι^l«ΦHr■"ι^,oιJι "PCΛ^"^(ldnιIι^O)ι d<!^ONlIl oco^"r ndιΛ^ ^«ooιnondMON_dιMΦσl ^^^l^NlOΦ(HOldoo»ι^)ιn σlOloood ln»"^ιnnNddNoooool ωmooι ιIιΦιn" ι^ιn'»Φ(^NHdNdβom(0(I!OOOoιIι^^ ιnιn^Λ(nωα)mα)M^ιn( ιr^ rθ ( ₁ ^, «^ 'T "» ro c C C C C C rOCl cOc r l CO CM CM CM CM CM CM CM CM CM CM CM CMCM CM CMCM CM CM CM CM CM CM H H H H H H H H H H H H H H H H H H H H H H H H

N(M ιn ιn xxxxaxxxxxxxxaxxxBxaxxxaaxaxaaxxxxaB xaaxxxxMxx sxxaxaxxBBxaxaxxBBXx o- cή x -; oc; ct; w ω w w D D D Q D D D D Cij cij ci Ci< θj i-j pL. c-i H5 H5 Hi Hi Hq j ^{H H H} >^{H H 4} H H H HH H ω c_ ι_i ω [-i ω w w co co cθ OTcq co w co rt rt rt rt rt rt rt rt rt rt rt rt rt rt ι^

E^H E^H E^H E^H E^H E^H χ χ x χ ^{j j} Hi HH Hα H; ι-i HH rt rt rt rt rt rt rt rt > > > > > > > > > > > > > ϋ ⁾ θ o o o c θ rt rt rt rt rt rt rt

H CM H CM H CM H CM H CM H CM H CM H CM o α ω td N X m CQ CD Q Q ft CQ CD Q Q PQ O CD ft PQ O CD ft co CD α ω ω < PQ O Q W N X B tt m

OOOCJUOZUOOUZUCJOOOUOZCJCJOOOOOZCJOOOUOZUUOOUUZUUOUUUOOZUUOUOUZCJZZZOOOO od^^ιffl'l^,ιn ^oD^O Nn"^ι) fflmod ιm"fιn ^ιIισlOH( M"»ιΛ ooαlOH(MM^ιn ^ωo odwι <rιn ^α!ι3lOdrιm"^^|ln ^1^^,"r<p^,V"^'"PvH^'Pιntnι^ιπιΛlnι/ltnιΛt ΦΦ Φ[^t^[^[^ι^^^^ ^^cocoa)coco ococoa)lDσlOl{Λσ σlσlσlmσlOloooooo

05 OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOHHHHHH rH yι τι σι yι <τ»σι cτι ^<y» <y» σ>σι τι cΛ 0^ <τι crι 0i ^ yι Λ rι CΛ (Tισι σι σι^ <τισι ^cΛ σι Λσι ^ σισι Λ σι σι cτι σι ^ VO

© εεssaεε§sasas εassεεa„_„_

OOOOOOOOOOOOOOOOOOO OOOaOsOaOε -_O§ o H ..■ it rtErtH ErtH frtH HrthrtHrtHrttrt< ErtH Ertι hrtErt^H rrtΕrt< Ert< trtι trtH Ertι ErtH frtH HrtrttrtH trtH ErtHrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrt ^' ft < ft < < < < ft ft ft < < < < ft tt ft ft ft

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

HHHH ri rH ri rH r rH r

CNcococococoroco ^,'^-n'r '' 'r ^ι'^'rιnιnιnιnιn-->ιnιnιnιnιn _> -> _> _> _i -> inininininininininininin nininioininininininininininintnininininininininininininininininininininininioinioi^ r- _{^ π} r. H Ε x χ 3H X 3H X Φ i! rπ X rϊ 3 rπ cή OOOO ooo cowOTWOTwwcocowooo ocDO

WX XpSPS X PSpS HHrHHHHHHHHCήΛpή SPfitf

CM H CM H CM H CM H H CM H CM

CD ft CQ CD Q ft BI O Q O W H rt CQ O Q W N X X ft CQ CD Q rt CO CD CD Q rt CQ CD Q Q < (fl O D W W rt X

O Z O O O O O O Z O O O O U Z O O Z Z CJ O O CJ U O Z CJ Z Z Z O O O U O O Z O O O O O O U Z O O O CJ U O U Z U O O U U O O Z Z O U O O

Tab 3

ATOM 9172 N GLY H 261 53.514 18.093 -5.397 1.00 30.77 N

ATOM 9173 CA GLY H 261 52.595 18.934 -6.148 1.00 31.72 C

ATOM 9174 C GLY H 261 52.630 20.414 -5.805 1.00 32.63 C

ATOM 9175 0 GLY H 261 52.069 21.230 -6.535 1.00 32.86 o

ATOM 9176 N Lεu H 262 53.279 20.769 -4.699 1.00 33.34 N

ATOM 9177 CA Lεu H 262 53.364 22.169 -4.294 1.00 33.16 C

ATOM 9178 C Lεu H 262 54.810 22.636 -4.198 1.00 33.78 C

ATOM 9179 o Lεu H 262 55.663 21.937 -3.653 1.00 34.08 o

ATOM 9180 CB Lεu H 262 52.654 22.372 -2.949 1.00 32.41 C

ATOM 9181 CG Lεu H 262 51.125 22.199 -2.974 1.00 32.91 C

ATOM 9182 CDl Lεu H 262 50.548 22.321 -1.561 1.00 31.68 C

ATOM 9183 CD2 Lεu H 262 50.515 23.261 -3.897 1.00 32.35 C

ATOM 9184 N PRO H 263 55.106 23.828 -4.730 1.00 33.86 N

ATOM 9185 CA PRO H 263 54.162 24.731 -5.398 1.00 34.62 C

ATOM 9186 C PRO H 263 53.692 24.210 -6.762 1.00 35.16 C

ATOM 9187 o PRO H 263 54.308 23.324 -7.353 1.00 35.17 o

ATOM 9188 CB PRO H 263 54.965 26.022 -5.514 1.00 34.70 C

ATOM 9189 CG PRO H 263 56.368 25.509 -5.724 1.00 34.09 C

ATOM 9190 CD PRO H 263 56.456 24.412 -4.689 1.00 33.37 C

ATOM 9191 N ALA H 264 52.593 24.767 -7.257 1.00 35.96 N

ATOM 9192 CA ALA H 264 52.052 24.354 -8.547 1.00 37.08 C

ATOM 9193 C ALA H 264 52.357 25.379 -9.637 1.00 37.85 C

ATOM 9194 o ALA H 264 52.493 26.572 -9.361 1.00 37.83 o

ATOM 9195 CB ALA H 264 50.559 24.159 -8.435 1.00 36.46 c

ATOM 9196 N ASN H 265 52.484 24.907 -10.872 1.00 38.58 N

ATOM 9197 CA ASN H 265 52.730 25.800 -11.995 1.00 39.78 C

ATOM 9198 C ASN H 265 51.564 26.790 -12.067 1.00 41.26 c

ATOM 9199 o ASN H 265 50.443 26.486 -11.653 1.00 40.55 o

ATOM 9200 CB ASN H 265 52.808 25.025 -13.317 1.00 38.66 c

ATOM 9201 CG ASN H 265 54.022 24.103 -13.399 1.00 38.73 c

ATOM 9202 ODl ASN H 265 55.143 24.494 -13.074 1.00 36.98 o

ATOM 9203 ND2 ASN H 265 53.799 22.877 -13.856 1.00 38.25 N

ATOM 9204 N ALA H 266 51.836 27.975 -12.595 1.00 42.81 N

ATOM 9205 CA ALA H 266 50.817 29.005 -12.714 1.00 44.32 c

ATOM 9206 C ALA H 266 50.978 29.762 -14.022 1.00 45.43 C

ATOM 9207 o ALA H 266 52.088 29.900 -14.547 1.00 44.88 o

ATOM 9208 CB ALA H 266 50.921 29.970 -11.545 1.00 44.47 C

ATOM 9209 N sεR H 267 49.861 30.253 -14.544 1.00 46.44 N

ATOM 9210 CA sεR H 267 49.873 31.010 -15.784 1.00 47.36 C

ATOM 9211 C sεR H 267 48.937 32.207 -15.656 1.00 47.83 C

ATOM 9212 o SER H 267 47.907 32.136 -14.976 1.00 47.58 o

ATOM 9213 CB SER H 267 49.441 30.110 -16.939 1.00 47.43 C

ATOM 9214 OG SER H 267 49.592 30.777 -18.179 1.00 49.15 o

ATOM 9215 N THR H 268 49.295 33.304 -16.313 1.00 47.79 N

ATOM 9216 CA THR H 268 48.477 34.512 -16.264 1.00 48.27 C

ATOM 9217 C THR H 268 48.836 35.504 -17.371 1.00 48.78 C

ATOM 9218 o THR H 268 49.878 35.383 -18.021 1.00 48.83 o

ATOM 9219 CB THR H 268 48.627 35.225 -14.899 1.00 47.98 C

ATOM 9220 OG1 THR H 268 47.774 36.374 -14.866 1.00 48.48 o

ATOM 9221 CG2 THR H 268 50.065 35.663 -14.677 1.00 47.38 C

ATOM 9222 N VAL H 269 47.961 36.481 -17.588 1.00 48.82 N

ATOM 9223 CA VAL H 269 48.196 37.507 -18.596 1.00 48.68 c

ATOM 9224 C VAL H 269 48.993 38.625 -17.919 1.00 48.43 c

ATOM 9225 o VAL H 269 48.927 38.781 -16.698 1.00 47.74 o

ATOM 9226 CB VAL H 269 46.858 38.082 -19.132 1.00 48.31 c

ATOM 9227 N VAL H 270 49.759 39.381 -18.699 1.00 48.71 N

ATOM 9228 CA VAL H 270 50.541 40.484 -18.142 1.00 49.74 C

ATOM 9229 C VAL H 270 49.587 41.324 -17.294 1.00 50.18 C

ATOM 9230 o VAL H 270 48.443 41.548 -17.689 1.00 50.16 o

ATOM 9231 CB VAL H 270 51.152 41.381 -19.264 1.00 49.84 C

ATOM 9232 CGI VAL H 270 51.888 42.557 -18.654 1.00 50.08 C

ATOM 9233 CG2 VAL H 270 52.109 40.574 -20.128 1.00 49.80 c

ATOM 9234 N GLY H 271 50.044 41.764 -16.124 1.00 51.04 N

ATOM 9235 CA GLY H 271 49.195 42.573 -15.265 1.00 52.18 C

ATOM 9236 C GLY H 271 48.353 41.793 -14.266 1.00 53.14 C TOM 9237 o GLY H 271 47.632 42.386 -13.459 1.00 53.93 o zυuozυcjoυuoozυuouυuzuuouuooozouooc υυuoozυoouc υzc υouwzoυoυuouzzc cjou

oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H I H H H H i ιn σι v o o o ^ ( βιn ^ n "ι^, n H ιΛ ι n <M ^ ι^,) (M ιΛ (^,) Ol ( « oo d ^l d n o ! O ^- d O ln o oι » H n "» o^,) 00 <I^ ln ^ ιJι ^ σι ι^ι d '» "l^| o f^,) ^ _ln □ a) (rι H ω σ^ M <l' lo ^ σl lo ^ ^ι H d eo m c Φ H O ^ oo ln N fl lΛ O ι^vι ι)ι o (0 o> ^ Φ β ^^ >» H H O) fn Φ Φ r^■ O fl ιJl N ι^ ιoo d oo ^ < ^ ^ ln ol ^ ^^ _ ^ ffl O (^ι co Φ lΛ oo ιn o o ιn » ιI co fl CM ^ r■ no ω n M ιn H d O o n n Φ H ι^,l (^,l ^ ^ H ^n ιΛ (M o rι

I' CO CM H H CΛ m O ao oo cΛ r^ oo oo r^ cD σι σι σι r-- ιn ιn co * ι* ro cM co ιn ιo co cM in co r^ r- <Λ oo cΛ co cM H CM H θ CM θ o I CM O O H CM CO CM CM CO I- lO r- 'J' t~ in H H H H H I I H I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I r• a) I1 o\ ιπ (^τl ιn o o ^^, ^ 1ι^, ^ (^ϊl ^ι O (^,^ o w ω ι d ^l d d ιl^, r^ ro o ^ Φ o co ( Φ Φ ι v c^ ιn ^n (Λ ιn d d r" Φ a) ^ σl ιn N d o r^ Φ H ^ N O (M o ιO (M σn¹^ Φ ιn cM H ιη H ι ^ oo t f ^ ι o ιn ( "J' <M H "l^, Φ o ι^ ι ^" tπ N ι ln ω o ω "^ ι ^ σ^ (M ^ oo f^ o ^" Co σ ω ^ H ^ o ^ H co (^ϊ^ H σl σl o ro lΛ ι^t ^ co o "r ^ σl (η ro O E t^ o σ_l fn m _ln "f ^ o^ ^ oo v ^ ^ m ^ ^^ n H © fn d σ^ lM (^l "1^, "l^, ^ ^ ^ ^ o o ^n co r. lO (J ^ ^ (D O (Λ σ o ^ ι ^ ^ oo o v Λ o ol m ol lD oo Φ o) O d o Φ v lι' ln "^ ln ^ι ι^,) <M d O N d d N O d w cn o o^ o ι!l d ιn H O ffl Φ ιn _ Φ Λ v ιn l lι^, n (\| d O d N H l d N H d d ι ro

-- r cO r cO ( (O c ro < '* lⁱ rO CO rO <O C <0 < CO CO CO CO CO <O CO ( l <O CM CM rO CM ro CM CO CM (O rO CM CM CM CM CM CM CM C^

cM cM CM CM r c r c c r "» ' 'r 'r ι -f in ιn -i ιn -i -^} ι ιn -'⁾ io ιo ιo _^ r~ r- r-- r^ c~ ι~ r- ι~ t~ r"- r- r-- r~ r~ r~ r-- r-- r-- r- r-- r--- r-- r-- r~ t~ r- r-- r~ r-- r-- r~ r^ r~ r~ ι~ t~ (~

Csl CM CM CM CM CM CM CM CM rM CM CM CM CM CM CM CM CM rM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM W

3-ι DC DC -t DC DC DC DC DC DC DC DC DC DC DC DC DC DC 35 DC DC DC 35 3? 34 C DC 33 DC DC DC DC DC 3 DC DC DC DC 3-* DC 3? 37 DC DC DC DC DC X DC DC DC DC DC DC DC DC DC DC DC DC DC DC DC < >^H >n < ai Ci< -i _ CU _ Hj H H5 Hl ij H3 H5 D D D D D D D W M W W W W I-I M ^

H^ i^j r^ H^ M w w in w OT in w rt rt rt rt rt rt rt J Hi H^ ^j Hi Hi ^j H^j Hi x a a a x x a x x x rt rt rt rt o o o c rt rt rt rt rt rt rt rt > > > > > > > o o cD θ θj θ4 C C« c- M Cij u cM ei4 P, > > > > > > > o u u υ o θ ιJ HH H3 H HH HH HH

H , CCMM HH CCMM HH CCMM H C CMM HH CCMM HH CCMM ft ft C co u Q Q u ω « m o D t CQ CD oυozoooo CQoDoQ Qoz rtooo PυQ OυCυzortooυ CQ CυD Oυ Woo Idz rtυo CQ C ooouυυυozυυocjoυzυcjoυwjzi ooυoD Qoυ W Nzzo ftoo CoQ ω m o rn tη "P

00 CM CM CM rH O i C o εaasaεaaaεaaaaεaaaaaεaaaεεεaεεaaaεaεaaaaεaaεεεεεaa aaaaaaaaaεεaaεεE oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo O ft < < ft ft ft tt ft ft tt < ft < < < < < < ft ft < < < < ft < ft ft < < < < < < ft < < < ft < < ft ft < ft ft < ft ft

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H H H H H H H H H H H H H H , H H H H H H H ι

ιncocor-ooc- r- -'ιnr- ιnr~cDιnσ>σiHCMCΛcjιcMcocoi'coιnιncorocor HcororoHHro ^ ^t ιθ τ o <Λoo σι oooΛ o r- r~ ι tn r- [~ m r- m o m 'n 'j' ι ιnro

HH HHHHHHHHHHHHHHHHHH (» r• _ ι^,lco o

-r CM CM CM f CM CM CM "3< _ Φ ιJl -1

o o d d d d d d d d d d d l ( N N (M N n ι») n (n ι»ι ι^,) n ( * "^ <f » ιl' ιn ιn ιn ln ln ιn ln ιn ιn Φ Φ Φ Φ Φ Φ ^ r> ^ ^• a! t(ι a! _ » al _

00 CD C_, _> O000 C CO _) 00 φ 0O 030000 O3 Φ 00 CO C 0D ro C 00 CO CO CO 00 CO CO CO CO CO ∞ CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

H CM I CM H CM I CM H CM H CM CJ) CD CQ CD Q Q C-I M NI X m C _ C „Q C_D Q Q m a _ u _ Q id ω CQ C _D _ Q CO CD Q Q U U ft PQ CD CD

OυzoυoϋooooϋoδzϋoocjozcJooυcjδδzϋcjoϋzcjoocJuoδzzδoocJuozouoouzoog! U J O J O O (»Ol O d( (η "» (D aι ιn ι) Φ Φ io Φ εεεεεεaaεεaaεεε O O O O O O O O O OO O O O O H Ei tH H H EH EH Ei h H tH H < < < < < < tt tt < < tt tt < ft

CO uzooououozzoυoouuυzυuυoozouoooouzouoooouzzoυouzuuooυozυuoouuzouocjz

oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H ιn σι ιn ιif B ln "l'<n o (Mm CM r0CM

x Bal xιL o o o o o o xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxaaaxxaxxxxxaaxxaaaxxxaxxaaa ωzzzzzszzzc &,ι_,a_JC Q_J αjQjΛ ^αιαιDuιωι_ιωωωι_ωωc c c c c c OT

H θ ω u U U U U D U μ h ^ H H tι H h h H H h H H H H H H H H H H J ιJ J J J J J J J a ϊ 3; S J! > > > > > > > ^|lι ^|lι ^|iι ^|lι llι ⁽- l- tι Eι [H iH H rl

Q rt ca αwia < QoααωωωoaNX ft CQ CD CD O < EI U Q U N ft f CQ CD CD ft co o Q < m c zυoouooozzouooυuozυυoυuzuoouuuozoooouoυzzυυoozuooυuυz uooc uυzυcjoυz ln ι>)

a o ft

υuoc ouc zc uoozuooc c cjzuυocjoυozououcjυuzzυυouzcjcjouzuuozuoouc uzuuoozcjuo

Tf 3 ro a_ δ ©

CΛ

H CJ

PH oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

HHHHHHHHHHH HHHHH, HHHHHHHHHH O CJl O n<Il ln mm

H n

CM M "tf ro mmd v ιιn H (MιnB ωι^,1 (Jι ' ' O Φ

o o o o o dd d d d d o o o o o o o H H H H H H H H H H H H co ro ro ro co croo rroo ro co co co ro co ro ro ro co c co

X X X X X xaxxxxxxxxxaxxaaxxxaaaaxaxxxxxxxxxxxxxxxxxxxxxxxxxxxaxxaxxxxx

D D D D D DD DD C O

Cd W C_ (_l l-l t_ 6Q OTO C H OTO C H O W H W OTOT >H >H ^ Hj Hj iJ rj H r^Q D D D D D D D D W W W OT W OT W CO W rt rt rt .-i Hl l-l ^-I J h-I J i-l HH HH HH HH > > > > > > J ^j i μ^{| |} J J J _h i ^j μi μi i J J J e⁽; rt; a < < «( «« 3. ϋ U U > > i> > > > < (i: < (< «< tH t< Ei r-

Table 3

ATOM 9502 CB THR H 319 60.234 37.120 7.028 1.00 43.83 c

ATOM 9503 OG1 THR H 319 60.967 38.310 6.712 1.00 44.68 o

ATOM 9504 CG2 THR H 319 59.213 36.859 5.921 1.00 42.87 c

ATOM 9505 N THR H 320 58.271 35.892 9.914 1.00 42.01 N

ATOM 9506 CA THR H 320 57.839 34.694 10.628 1.00 42.17 c

ATOM 9507 C THR H 320 57.305 33.541 9.773 1.00 40.98 c

ATOM 9508 o THR H 320 56.901 33.738 8.627 1.00 40.68 o

ATOM 9509 CB THR H 320 56.792 35.101 11.700 1.00 43.14 C

ATOM 9510 OG1 THR H 320 57.448 35.887 12.702 1.00 45.22 o

ATOM 9511 CG2 THR H 320 56.151 33.889 12.360 1.00 45.06 c

ATOM 9512 N ASP H 321 57.318 32.333 10.342 1.00 39.70 N

ATOM 9513 CA ASP H 321 56.835 31.149 9.639 1.00 38.81 C

ATOM 9514 C ASP H 321 55.326 31.172 9.375 1.00 38.85 C

ATOM 9515 o ASP H 321 54.837 30.461 8.507 1.00 38.89 o

ATOM 9516 CB ASP H 321 57.197 29.874 10.411 1.00 37.34 C

ATOM 9517 CG ASP H 321 58.693 29.589 10.407 1.00 36.21 C

ATOM 9518 ODl ASP H 321 59.383 30.100 9.500 1.00 35.02 o

ATOM 9519 OD2 ASP H 321 59.166 28.843 11.296 1.00 33.81 o

ATOM 9520 N LYS H 322 54.590 31.993 10.120 1.00 38.99 N

ATOM 9521 CA LYS H 322 53.143 32.083 9.953 1.00 38.60 C

ATOM 9522 C LYS H 322 52.720 32.329 8.499 1.00 37.91 C

ATOM 9523 o LYS H 322 51.747 31.742 8.015 1.00 36.72 o

ATOM 9524 CB LYS H 322 52.580 33.199 10.846 1.00 38.53 C

ATOM 9525 N GLU H 323 53.458 33.182 7.797 1.00 37.47 N

ATOM 9526 CA GLU H 323 53.112 33.495 6.419 1.00 37.78 C

ATOM 9527 C GLU H 323 54.225 33.234 5.394 1.00 37.88 C

ATOM 9528 o GLU H 323 54.135 33.667 4.244 1.00 37.65 o

ATOM 9529 CB GLU H 323 52.645 34.953 6.336 1.00 37.67 C

ATOM 9530 N ILE H 324 55.257 32.502 5.801 1.00 37.50 N

ATOM 9531 CA ILE H 324 56.370 32.225 4.904 1.00 37.08 C

ATOM 9532 C ILE H 324 56.077 31.163 3.821 1.00 36.29 C

ATOM 9533 o ILE H 324 56.713 31.166 2.773 1.00 35.74 o

ATOM 9534 CB ILE H 324 57.631 31.849 5.737 1.00 37.12 C

ATOM 9535 CGI ILE H 324 58.866 32.552 5.159 1.00 38.18 C

ATOM 9536 CG2 ILE H 324 57.798 30.336 5.816 1.00 36.42 C

ATOM 9537 CDl ILE H 324 59.214 32.162 3.758 1.00 38.53 C

ATOM 9538 N GLU H 325 55.097 30.291 4.048 1.00 35.93 N

ATOM 9539 CA GLU H 325 54.785 29.252 3.069 1.00 36.88 c

ATOM 9540 C GLU H 325 53.963 29.653 1.841 1.00 37.34 c

ATOM 9541 o GLU H 325 53.660 28.815 0.996 1.00 36.84 o

ATOM 9542 CB GLU H 325 54.137 28.064 3.769 1.00 37.33 c

ATOM 9543 CG GLU H 325 55.112 27.279 4.649 1.00 38.42 c

ATOM 9544 CD GLU H 325 54.409 26.228 5.498 1.00 39.29 c

ATOM 9545 OEl GLU H 325 53.518 26.613 6.291 1.00 39.31 o

ATOM 9546 OE2 GLU H 325 54.742 25.029 5.368 1.00 37.77 o

ATOM 9547 N VAL H 326 53.603 30.925 1.728 1.00 37.78 N

ATOM 9548 CA VAL H 326 52.862 31.373 0.556 1.00 39.52 c

ATOM 9549 C VAL H 326 53.555 32.610 -0.020 1.00 39.99 c

ATOM 9550 o VAL H 326 53.880 33.536 0.714 1.00 40.78 o

ATOM 9551 CB VAL H 326 51.375 31.676 0.903 1.00 40.06 c

ATOM 9552 CGI VAL H 326 51.289 32.735 2.006 1.00 41.95 c

ATOM 9553 CG2 VAL H 326 50.638 32.143 -0.342 1.00 39.31 c

ATOM 9554 N LEU H 327 53.817 32.597 -1.326 1.00 40.27 N

ATOM 9555 CA LEU H 327 54.478 33.712 -2.006 1.00 40.64 C

ATOM 9556 C LEU H 327 53.508 34.372 -2.970 1.00 42.00 C

ATOM 9557 o LEU H 327 52.989 33.720 -3.882 1.00 41.64 o

ATOM 9558 CB LEU H 327 55.700 33.238 -2.803 1.00 38.86 C

ATOM 9559 CG LEU H 327 56.432 34.300 -3.636 1.00 37.79 C

ATOM 9560 CDl LEU H 327 57.253 35.215 -2.718 1.00 36.93 c

ATOM 9561 CD2 LEU H 327 57.346 33.624 -4.645 1.00 36.04 c

ATOM 9562 N TYR H 328 53.277 35.666 -2.769 1.00 42.93 N

ATOM 9563 CA TYR H 328 52.371 36.427 -3.624 1.00 44.15 C

ATOM 9564 C TYR H 328 53.129 37.341 -4.591 1.00 45.79 C

ATOM 9565 o TYR H 328 54.136 37.956 -4.226 1.00 45.90 o

ATOM 9566 CB TYR H 328 51.400 37.278 -2.770 1.00 42.30 C

ATOM 9567 CG TYR H 328 50.434 36.476 -1.911 1.00 41.07 C CO ouuooozooooouυzuooυoozuzzzoooυoozzoooυuozooocjoozouoozoooozoυoυuooz

ooooooσooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H , H H H H H H H H H H

lo m oo r- co ιnoo σισ>θ ιn <o ro fin nnf iη ( "i^, rι

ι ι* 'τ 'r ι^ι ι^ι ι ι ι ι ι ι ι ι ι ι ι ι i i' 'i⁴ 'r * ι^, ι ι ι u ι ι ι ι ι ι ι ι ι ι ι ι ι ι ι ι ι ι ι ι ι i . i i

ωffl mmmσl5ι ^βιιΛOll⁾lO o oo oooo ooo d d d d d H d l N NN !M lM N (^»)mnn n(^«)n^ "l' < 1^l "^ ln ιn ln ιn lnΦ Φ Φ

CM CN C CM CM CM CM CMCM CM CM CM CM CN lO CO rO rO rO CO rO CO COCO rO C lO CO r COM co co ro ro co c c coco r c (O rn co co co ro r ro ro ro ro cocoro c coro (O coco co co co ro ro ro < <o ro (o c ro n xxxxxxxx axaaxxaaxaxxxaxxxxxaxxxxxaxxxxxxxxxxxxxaxxxxxxxxxxxxaaxBXB ω oc ooooo _ιoc_ z z z z z Z Hq HiHiιJ j μi ιJ g pt; p- g χ pc; p- ω ω ωωω DD D DD Hi rt ^pή pήrt rt pci pζ rt pή x cή co OTco o co co o rt rtrtrt rt rt rt x x x x x a x x x x x x j Hi Hq j

HCMHCM HCMH HCM HCM HCM HCM HCM

Q Q C-5 C-1 N X ft CQ CD CD Q < CQ CD Q W oq X X ft X CD Q Q ft PQ CD CD ft CQ CD CD ft CQ CQ ft CQ CJ) Q Q

O O CJ O O O Z O O O O U O U Z CJ CJ O O O U Z CJ Z.Z U CJ O U U O Z Z U U O U O O Z O U O O O U Z O O O CJ Z CJ CJ O CJ Z CJ O O O U O O Z

O O O CJ Z CJ CJ O Z CJ U O CJ O CJ O O Z U O O CJ U CJ U O O CJ O Z U CJ O O O O Z O O O O CQ Z O U O O CJ O O Z CJ U O CJ Z J U O Z O CJ O O O O

Tf Tf -_ r- ro δ ©

u OO ffl ιn * « n H h ιn * N ft N M CO * <Λ »O N ιH « 00 (Λ W ^ ιn θ ιn H lOrt N <Λ ιnci ffl W O N ^ lΛ <Λ OO H N V Λ N I- lO ιn ra θ ^ o ι~ nm » ^ ιn d d ω ιn N in N Φ i i!i ^ r~ n ι^,) θ r- n ιJi w o <M H (M ^^ι <r "r ω ι^r) i») ω v H N N in i~ ιn w ffι i») θi N m cM θi ι») ιη

PM ^ φ φ ln "]^, "P (n c^ι(M O O ( V Φ ^ o B ^ B O σl σι o o H (M ln ^ ^ ^^ Λ ^ Pl (^,^ n (M <M c H O σ σl H ( ^^, ^^, m m B ω B ^^■ Bfl O O H O ^, ' '» "» 'r 'r ^, 'r "* ι ' "» 'r "- "* 'r 'r ( r c < ro r r r "* "3^, «r 'r r ro r o r r r <o o < (θ co cNi c^ oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

HHHHHHHHH, IHHHHHHHH,

Φ m d in Ol

r~ t~ c~ r~ ao oo

⁽O fθ π ⁾ PO ⁽l ro ro c ro ro ⁽O xxxxxxxxBXBXxxxxBXXBBXxxaaaaaBxxxxxaxxxxxxxxaBxaaxaxxaaaxaxaaBBBaB

3 A ^Q O O ^Q O ^Q O O O & Λ & & & ^{ύ ^Qt Λ & & & & 0C, & & & & 0i & m m ui m υ⁾ m ^Q O O Q O Q O & rtrtrt J>< < <ZZZZZZZ

< < 0 - O ϋ O U C5 U θ i ϋ O - H H t< H h H h tι tι EH H tι Eι t< h h h [ι !H U O ϋ U U U Hl Hl J J iH j J rl tt < ft O O < ft < tt tt tt <

H CM H CM H CM H CM H Q Q ω w uooυzc oozυυoooooozuu X O Q Q W W KI X C^Q CD CD rt C^Q CD rt CQ CD ^{Q Q} rt CQ rt rt m D Q O O U O CJ U CJ CJ O Z CJ U O oouzoooυcozυoooouozooouzooozoooυoo

Hl^| ιn » <Λ O <M ) ^ ln ^ B O O d ^l (0 ^ ln » m o H CM (^ ^ ln ^ B Λ O H N n ^ ιn Φ ^ oo (Jl O d (M (0 •* ι 03 c^ o d < σ) * ιn Φ m m r co co r o "τ ' ^ι " 'r 'r "T "^ "^ ιn ιo tn ιθ ι ιo ι ιn ιn ιn co cD co cD vo ιo vo cD vD io r^ r^ r^ r^ r^ r^ ι^ r^ r^ c^ co oD oo α5 o cx) co o^

CO IO CO IO CO IO CD IO VO VO CD — > CO CO l£ I IO CO CD O IO ID CO IO VO IO CO IO CO CO IO CO VD ID CO IO IO IO CO CO IO IO IO CO IO IO CO IO IO IO IO CO IO CO CO VO IO IO CO O IO VO ID IO IO IO IO CΛ CΛ CΛ CΛ σi σt σi CΛ CΛ CΛ CΛ cyi C C CJl CΛ C CΛ CΛ CΛ CΛ CΛ O^ C^ rH εoεoεoεoεoεoεε a HoHoε Hoooaoa oεε aε aa ε EH H EHoa EHoεε hohoε hooε ε hoε EHoh £oHohoa tι hotoιoa EHoaaaaaaaaaaaaaaaaaaaaas h o aaεεooεεεεεεεεεεεa o h tι EH h EoH hoh toι Eo< H hoohoEHootιoh tooEHoEHoEιoEH ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft

cocococoror rororonrococ rocococococ cororoc cocoro ocororocornroc rocofocoroc coc^

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OO OOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H H H H H H H H H

CI N co

00

Φr^• ^^ ^ BBBBBBββ<⁾ιo^w^βιooooooooHHHddd<^lN ιw^ι ι«NM ι ιι<)nnn^(|)π1nnι^,)n»»*«»^ιnιnιnιnιnΦ i"^'r"^ ^«'r i'^ i'^'H'^ιι ιιιιιιιιιι ιnιnιnιnι ιnιnιnιnιnιnι ι ιnι ιnιnιnι ιnιnι ιnιnιnιnιnιnιnι ι ιnιnιoι ιn^ coro c ro ro coro c ro ^pι ι (o m <o < ro ro < c ro c (θco coc foc c coro c co ro (θ ro ro co ro n co ro rθ (o ro <^

X X X X X X X X X X X X B X X X X X X B X X X X X X X B X B X X X X X X X X X X X B X X X B X X X X Z Λ Λ Λ Λlϊ li W HW IJ Iil W W M ^ ^ ^ ^ M W B M W W M B Λ j IlJ Λ Λ Λ H W H W Iii ω W W W W W ra n ra

^C a^Λ td t-I I-i ω ω i-l Hl J ^j Hl H^ Hl Hl J Hq Hl HP Hl H Hl H^ Hq H^ Hl HJ H^ ω i-i ω i-i ω

CO C CO CO CO CO H H H H H H H H O CD O O H H rH H H PH H H W CO CO CO CO CO P« l-l l-l P^ Pl4 pJ ^ p4 »j Λ C-l X X X B X X X X X X CO CO C Cn CO W tt < < ft >

^Q rt P^Q CD ft CQ CD CD ^Q ft CQ CD CD Q ft CO D < H U Q Q I-U N ft CQ CD Q Q C- W < CQ CS ft CQ zzooooozc^jooυooozc υozυoouuc^jozcjc oυozooouoυυυc ozυooυυzυozzuuouozcjoouz 1' 'r ι^, "^ 'r '* 'y ιnιn ιn ιn ιn

Table 3

ATOM 9766 CA TRP H 356 56.986 27.507 -13.370 1.00 43.37 C

ATOM 9767 C TRP H 356 55.856 28.520 -13.500 1.00 43.51 C

ATOM 9768 0 TRP H 356 54.678 28.181 -13.360 1.00 42.74 O

ATOM 9769 CB TRP H 356 57.195 26.809 -14.713 00 46.21 C

ATOM 9770 CG TRP H 356 58.585 26.940 -15.259 00 49.86 C

ATOM 9771 CDl TRP H 356 59.119 28.023 -15.910 00 51.19 C

ATOM 9772 CD2 TRP H 356 59.622 25.955 -15.199 00 51.39 C

ATOM 9773 NEl TRP H 356 60.428 27.770 -16.259 00 52.44 N

ATOM 9774 cε2 TRP H 356 60.761 26.508 -15.834 00 52.70 C

ATOM 9775 cε3 TRP H 356 59.700 24.659 -14.670 00 52.30 C

ATOM 9776 CZ2 TRP H 356 61.967 25.805 -15.956 00 53.75 C

ATOM 9777 CZ3 TRP H 356 60.899 23.957 -14.790 00 53.65 C

ATOM 9778 CH2 TRP H 356 62.016 24.533 -15.430 00 54.68 C

ATOM 9779 N LEU H 357 56.228 29.771 -13.749 00 43.57 N

ATOM 9780 CA LEU H 357 55.241 30.821 -13.948 1.00 44.37 C

ATOM 9781 C LEU H 357 55.264 31.210 -15.419 1.00 44.97 C

ATOM 9782 o LEU H 357 56.306 31.606 -15.943 00 44.95 O

ATOM 9783 CB LEU H 357 55.553 32.063 -13.102 00 43.75 C

ATOM 9784 CG LEU H 357 54.647 33.275 -13.395 00 43.33 C

ATOM 9785 CDl LEU H 357 53.199 32.930 -13.065 00 42.94 C

ATOM 9786 CD2 LEU H 357 55.097 34.483 -12.592 00 42.64 C

ATOM 9787 N THR H 358 54.125 31.072 -16.088 00 46.14 N

ATOM 9788 CA THR H 358 54.021 31.455 -17.494 00 47.09 C

ATOM 9789 C THR H 358 53.217 32.748 -17.602 00 47.54 C

ATOM 9790 o THR H 358 52.111 32.851 -17.070 00 47.65 o

ATOM 9791 CB THR H 358 53.347 30.355 -18.357 00 47.36 c

ATOM 9792 OG1 THR H 358 54.224 29.223 -18.454 1.00 46.99 o

ATOM 9793 CG2 THR H 358 53.059 30.880 -19.769 1.00 47.09 c

ATOM 9794 N VAL H 359 53.798 33.739 -18.273 1.00 48.63 N

ATOM 9795 CA VAL H 359 53.150 35.035 -18.462 1.00 50.08 C

ATOM 9796 C VAL H 359 52.862 35.241 -19.946 1.00 51.19 C

ATOM 9797 o VAL H 359 53.779 35.297 -20.764 1.00 50.62 o

ATOM 9798 CB VAL H 359 54.040 36.198 -17.960 1.00 49.65 C

ATOM 9799 N LEU H 360 51.576 35.351 -20.280 1.00 52.47 N

ATOM 9800 CA LEU H 360 51.122 35.539 -21.659 1.00 53.75 C

ATOM 9801 C LEU H 360 50.855 37.013 -21.990 1.00 54.89 C

ATOM 9802 o LEU H 360 50.672 37.836 -21.086 1.00 54.42 0

ATOM 9803 CB LEU H 360 49.859 34.711 -21.882 1.00 52.68 C

ATOM 9804 CG LEU H 360 50.030 33.232 -21.527 1.00 52.35 C

ATOM 9805 CDl LEU H 360 48.682 32.530 -21.579 1.00 51.71 C

ATOM 9806 CD2 LEU H 360 51.018 32.582 -22.494 1.00 51.91 C

ATOM 9807 N PRO H 361 50.829 37.360 -23.292 00 56.57 N

ATOM 9808 CA PRO H 361 50.587 38.734 -23.759 00 57.88 C

ATOM 9809 C PRO H 361 49.152 39.223 -23.536 00 59.14 C

ATOM 9810 o PRO H 361 48.215 38.421 -23.432 00 58.75 o

ATOM 9811 CB PRO H 361 50.945 38.653 -25.241 00 57.63 C

ATOM 9812 CG PRO H 361 50.519 37.252 -25.605 00 57.72 C

ATOM 9813 CD PRO H 361 51.068 36.459 -24.436 1.00 56.77 C

ATOM 9814 N ALA H 362 48.988 40.540 -23.458 00 60.86 N

ATOM 9815 CA ALA H 362 47.671 41.137 -23.245 00 62.45 C

ATOM 9816 C ALA H 362 47.003 41.386 -24.592 00 63.55 C

ATOM 9817 o ALA H 362 47.664 41.329 -25.630 00 63.78 O

ATOM 9818 CB ALA H 362 47.810 42.457 -22.470 00 62.08 C

ATOM 9819 N PRO H 363 45.687 41.657 -24.605 1.00 64.64 N

ATOM 9820 CA PRO H 363 44.919 41.923 -25.837 1.00 65.06 C

ATOM 9821 C PRO H 363 44.966 43.393 -26.248 00 65.26 C

ATOM 9822 o PRO H 363 45.828 43.746 -27.072 00 65.96 O

ATOM 9823 CB PRO H 363 43.491 41.523 -25.462 00 65.00 C

ATOM 9824 CG PRO H 363 43.656 40.661 -24.196 00 65.12 c

ATOM 9825 CD PRO H 363 44.777 41.349 -23.490 00 64.84 c TabU 3

HETATM 9827 S S04 9001 46.360 43.651 14, .525 1.00 80.11 S

HETATM 9828 01 S04 9001 45.130 42.976 14 .081 1.00 80.85 o

HETATM 9829 02 S04 9001 46.043 45.024 14 .953 1.00 79.61 o

HETATM 9830 03 S04 9001 46.944 42.914 15, .659 1.00 80.93 o

HETATM 9831 04 S04 9001 47.320 43.674 13, .407 1.00 79.94 o

HETATM 9832 S S04 9002 39.893 32.643 -36, .234 1.00 57.87 S

HETATM 9833 01 S04 9002 40.848 33.615 -36, .811 1.00 58.67 o

HETATM 9834 02 S04 9002 40.300 31.273 -36, .580 1.00 58.27 o

HETATM 9835 03 S04 9002 39.894 32.781 -34 .766 1.00 57.83 o

HETATM 9836 04 S04 9002 38.548 32.894 -36, .778 1.00 57.44 o

HETATM 9837 S S04 9003 76.012 20.398 36, .658 1.00 64.33 S

HETATM 9838 01 S04 9003 76.273 20.228 35, .214 1.00 64.38 o

HETATM 9839 02 S04 9003 76.984 19.588 37, .421 1.00 65.03 o

HETATM 9840 03 S04 9003 76.155 21.819 37, .013 1.00 64.70 o

HETATM 9841 04 S04 9003 74.644 19.964 36. .986 1.00 63.96 o

HETATM 9842 S S04 9004 82.383 9.280 -14. .072 1.00 88.97 S

HETATM 9843 01 S04 9004 82.503 10.218 -15, .201 1.00 89.47 o

HETATM 9844 02 S04 9004 83.325 8.161 -14. .260 1.00 88.96 o

HETATM 9845 03 S04 9004 82.686 9.986 -12. .808 1.00 88.61 o

HETATM 9846 04 S04 9004 81.009 8.751 -14, .037 1.00 89.30 o

HETATM 9847 o HOH 8001 30.583 19.182 -20. .544 1.00 21.98 o

HETATM 9848 o HOH 8002 76.423 -6.864 9, .843 1.00 23.00 o

HεTATM 9849 o HOH 8003 19.265 31.410 1. .209 1.00 22.84 o

HεTATM 9850 o HOH 8004 61.744 -4.031 28. ,962 1.00 22.37 o

HεTATM 9851 o HOH 8005 66.826 33.841 20. .938 1.00 23.18 o

HεTATM 9852 o HOH 8006 18.482 37.390 8, .210 1.00 23.45 o

HεTATM 9853 o HOH 8007 54.625 15.653 -7. .780 1.00 22.48 o

HETATM 9854 o HOH 8008 59.923 9.805 49. .344 1.00 26.25 o

HETATM 9855 o HOH 8009 72.094 23.144 24, .607 1.00 19.78 o

HETATM 9856 o HOH 8010 14.982 26.494 6. .291 1.00 21.68 o

HETATM 9857 o HOH 8011 40.246 59.911 -9. .530 1.00 24.78 o

HεTATM 9858 o HOH 8012 15.805 46.501 5. ,661 1.00 29.73 o

HETATM 9859 o HOH 8013 55.380 21.613 -0. .817 1.00 23.35 o

HETATM 9860 o HOH 8014 16.573 46.338 9. .812 1.00 24.34 o

HETATM 9861 o HOH 8015 51.751 6.536 -5. .223 1.00 27.38 o

HETATM 9862 o HOH 8016 36.033 29.962 -24. .110 1.00 23.25 o

HETATM 9863 o HOH 8017 25.606 57.088 -28. .459 1.00 22.89 o

HETATM 9864 o HOH 8018 73.859 -2.056 4. .603 1.00 19.45 o

HETATM 9865 o HOH 8019 51.125 26.594 -5. .604 1.00 24.70 o

HεTATM 9866 o HOH 8020 66.880 25.381 9. .858 1.00 28.68 o

HETATM 9867 o HOH 8021 38.023 25.055 -28. .614 1.00 22.96 o

HETATM 9868 o HOH 8022 26.996 30.474 -16. .396 1.00 23.98 o

HETATM 9869 o HOH 8023 25.809 19.877 -17. .801 1.00 24.38 o

HETATM 9870 o HOH 8024 45.339 47.075 -3. .217 1.00 24.47 o

HETATM 9871 o HOH 8025 58.457 26.484 18. .703 1.00 28.38 o

HETATM 9872 o HOH 8026 37.737 55.122 -4. .166 1.00 21.76 o

HETATM 9873 o HOH 8027 62.668 37.972 3. .726 1.00 37.90 o

HETATM 9874 o HOH 8028 76.437 -7.756 13. .648 1.00 21.50 o

HETATM 9875 o HOH 8029 52.710 6.639 -9. .379 1.00 25.02 o

HεTATM 9876 o HOH 8030 81.344 5.935 3. ,580 1.00 25.92 o

HεTATM 9877 o HOH 8031 23.909 43.293 -49. .084 1.00 22.88 o

HεTATM 9878 o HOH 8032 24.078 33.069 8. ,400 1.00 30.55 o

HεTATM 9879 o HOH 8033 49.020 60.054 -0. .925 1.00 30.74 o

HεTATM 9880 o HOH 8034 74.099 28.029 29. .070 1.00 28.15 o

HεTATM 9881 o HOH 8035 65.801 0.287 24. ,875 1.00 34.23 o

HETATM 9882 o HOH 8036 58.785 1.057 -24, .404 1.00 24.39 o

HETATM 9883 o HOH 8037 28.568 14.884 -9, ,616 1.00 34.53 o

HETATM 9884 o HOH 8038 54.116 2.380 -18. ,860 1.00 29.41 o

HETATM 9885 o HOH 8039 30.881 27.679 -9, .394 1.00 27.68 o

HETATM 9886 o HOH 8040 65.552 4.439 59. .031 1.00 25.86 o

HETATM 9887 o HOH 8041 65.513 10.326 -17. ,439 1.00 30.59 o

HETATM 9888 o HOH 8042 17.929 50.681 19. ,191 1.00 28.19 o

HETATM 9889 o HOH 8043 68.778 6.931 16. ,604 1.00 39.86 o

HETATM 9890 o HOH 8044 67.164 12.773 5. ,516 1.00 33.07 o

HETATM 9891 o HOH 8045 55.249 8.894 45. ,955 1.00 29.25 o O O

ιJl O N« lfl oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

I H H H H H , I rH rH rH rH ri ri ri rH rH , r o ι σ> co r^ r^ co o oo r-- α) θθ 'r 'r oo oD VD σi H θ <τι cM t~ r~ ιn co cθ 'r r cM ι o ' c 3 <M t~ r~ ι^, ιn r- D H co 'i' r~ i' C H c CoO oO ιmn cCMM CO in rO VD OO CΛ H I' lⁱ ' CM co c~ ι t co co r~ M o o vo o r~ r- r-- ι H i^, ω r^ o r-- "» o co <Nj c) CΛ H r <Λ r ( CD CΛ co ι θ H r~ σι θ H r- H θ H in σ> o c θ — H oo oo cn cθ ^(j> cM σι cM θ ι< r^»

OO ιn H OO CM 'T CM 001 O ( OO θ r ", r~ O M H 'r ιn (O O CΛ <Tl O CO CM ιn ⁽Λ CO CM H O C r~ CO O CTl H f CΛ H ιn cM 01ι <Λ σι OO OO OO _> H O r- co σ> ιn H o m H CM co co i cM iⁱ vD in co σi c oo f- o H CM CD <o cθ '* CM θ ιn (Λ ιn ro r~ 'r H o σι co c '* co o r~ CM r~ H H H CM r-- oo vo o ' r- r~ H <x> oo t~ θ ( io c~ <Λ oo ιn co oo H θ io

CM I H I I 1¹ CM H H H CM CN H CO H CM I H CM CM I CO H H I H H I H H I H I H CM CO m CM H ⁱ H I I H H H H CM CM H

I I I I I I I I I I I I I I I I I I I I

( O O d O ι») <n « "r n "l' ^ d d ι ι>) ^^ Φ Λ ^ Φ d v (O ^ Φ ιn (^,) - l^,l d ιfl (^,l ι ιJl m Φ d d H O H <M l0 1^, "f M H (Jl (M "f ln o N Ol ^ f d ln v ^ n o ol ( d B r) (n ιn Φ ^ ln d ιn ln Φ o d ^ Φ fl n n βl N N d lJl QO d r• ι^,) d N l^ tM H|^l d o o ^^ ιn o ffl M m u "» m B Ol ιn o ιΛ d ln β 5\ H m H H n N ^ι ιIl l ln o 9 Λ d O ^ ω o oo >^ ιn σ^ ω ln ^l B ^ ω oo o n Φ O Φ ι<) Φ "l' "l' r- Φ n ^ NO "l' ιn "» σ^ B Λ ( d d d ι ιn "f ιn ln ^ n ln N v ^ ( B O "^ N N N ι^ ln ι ιn Φ d o m ^ d O O ( rl (^ι o O "^ "^ H t" B n o (ι ^ d ^ m o B ι>ι lΛ » ι» f1 ι⁾^ ι<) ^^ >^ N Φ m CO lD H H T CM H CM CO CD -!^■ I Iⁱ CM I C m CM -O l r in M CD i i l n T D H C l r l ' CM CM H CM H H 'tf CM I' H I M CO H H I in H H H I¹

I I I o ιr) n σl ( N O o αl o o ( <)l d Ol Λ ιn o B r- d m ιn "l^l

ω ol O N ⁽0 « m B σl O 9 « « « ιn ι ιn ι ⁾ ιn ιo ιn ι ln o o H H

O O O O O O O O O O O O O H H H H

∞∞∞∞oooo∞rooo∞∞oo∞

BB X XX X BXXXXXBBBXXXXXXX XXBBXXBBB BXBXBBX XBBXXXXXBXX XXXXXXBXB XBXBBBXB OO O OOO O O OOO OOOO O OO O OOOOOOO OOOOO O OO O OOO O OO O OOO O OOOO OOO O OOOOOOOO O OOO

33 3-ι 3-i _C __ 3-ι 3-ι 3-ι 33 S DC EG 33 DC DC DC DC DC DC DC DC 33 DC 333333 33 33 33 DC 33 DC 33 DC DC DC DC DC DC 3? DC 33 333333 33 33 DC DC D DC DC DC DC DC DC DC DC DC DC DC DC DC DC DC DC

O O O O OO O O OO O O OO O OO O OO OOOOOO OOOOOOO O O OO O O O O O OO O O O O O O OO O O O O O O OO O O O O 0l O d M ι»l "f ln r' ' ^, ιn ιn ιn ιn ιn ιn ιn ιn

ooooooooooooooooooooooooooooσooooooooooooooσooooσooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

I H H H H H H H H ,

CM H CM H i m CM I

O in

CMCOT inCOr-OOσiOHCMCO ^ιn OlOd^ιι«l<»ln r■ωoιo <Mn"f ιf) σlO Nιη"JK1 fll)aιo ιι<)"lιιnΦ^-∞cIlO ( n"l^|ιnΦ HHHHHHHHCMCMCMCM ( ( r cMcs|C r f (i)r^,)f roc rt(θ(^'r"r^^,"r"r"j^,^^,^^,^^, ")'inιnιnι/lιθιnιoiΛinιn ΦΦΦ Φ Φ Φt-r t^ι^r-[.r^,-r*

H HH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHHHHHHHHHHHH ooooooo30oooc&ooo3cococx>oocococococococoroa>ODOoa)c_c rooococococococoro

X X X X XSXBXXXXX X X X X X X X X X X X X X X X X X X X X X X X X H4 X X X X X X X X B B X X X X X B X B O O O O OOOOOOOOO O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O OOO O O O O

X X X X o

X X X X B X X B B X X B X X X X X B X X X B X X X X X X X B B B X X X X X o o o

X X X o X X X X X B X x X x x O

X o o X X o X x o o X x o o x oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

__ r_

CJ

© o

<^ ^ ^ n N β Φ ιn m ^ ιn o ^ cM H m Φ () ^p ^ r• o n d l B N ^l o ^ o^l lΛ ιn n ωιIl ι<l O H « "^ ι-^• ^ ^ >^l ^ ^ι o w ι»> ιn Λ ιl) O ^ r~ 0l ^ι u d ^ <Jl ^ Φ O^ o (rι Φ B v f d B O ^ι^, O d (M '^ 'I O ^^ ^ "f n o ιn ιJl '» 0 ^ <Jl ^ r- ιπ "f « d Λ σl ^l O N c^ ⁽Il (Iι ^ Φ Φ O Φ O m Φ d d ιJl lJl

PM O n ω '^^, H ^ B ι^,l ω m Ol d (») ( w o ι»ι ^ o o O Hl^ ln l <Il O "» B n o o !M P) n « o ι!l 1^| w ^^ tM O> ^ M O Φ o ^ ol ι^,^ Φ B B B Dl l!^ Φ H ( B <^, ro oj co ro co c ⁽θ CM co cM co co cM co ro co cM CM '^ CM ⁽ co co ι co cM "* c ⁽M ro ^«τ co ^, co co co ^| CM ro co ro ro cM CM r^ oooooooooσoooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

H in ^, H co o o o ' vo o cn ιn co o vo σ^ ro ι~ oo co cn ιn σι ι ιo ιo vo o^ o ιn o f o r o <n o ιn H in co oo cM ro cM in oo co cD r~ o σι σ ro cn co co o 'r oo cD 'r cn ro o ^f 1ir (D H^ Φ d ^ιι u) Λ "» d ^ o ln ιn 9 'fl^, N O Φ <M f^,1 ^n c^ ^^ ⁽Il O ι<l N ^ » ln ιo n Λ O lO ι1 MO ( d (o o d ^ N O d π n n o ^l d N r• ^ 0l (Il o ^ d o ^ o o (1 (Jl ln o o o 5l 0l ι^,^ Φ d HP d D "f N B O <J 0l '» n B O O H H Φ ^ ^^ B N Φ ι ^ ^ ^ ^^ r) r• o ^" O ιΛ n

<ι^, r• ^ lnH ^ r• d r• d ^ "l' ln m -) N r• m o o ^ d l ln ^ d C H B ln ( • 0 "» H Φ O ^ r• ιn m ln r> (n ^ Φ N d Φ ιn d l m o Φ

I Λ N N I « d N I I I I I CM CO H CO m I CM I H CM H CM CO H Φ CM H CO CO H CM H I ri I ill CM H I CO CO I H ri CM CM H H H H ri

I I I I I I I I I I I I I I I I I I I I I ιnΦ r- O B Jl Φ ()l N d Λ ι^ n Φ ln ^ w Φ Ol ( ^ « ^l B ^ Φ σl ιn B (M ln ^ d "f O H m ιn c> ^ ^ w ιJl ^^ O ( <M O l Ol φ o ^ Φ l l') Hl' lM O <)l ^^■ m ω m ^ m "f O "» ffl l (M ln Λ ^ c ra N O ιnn <M ι) _ 0 (M n Φ O ιn H n N » ln B n H ι^,) ^ι Φ O "l^| ln o ^ ln ^ n α) d H O ^ι m o ιn lπ <Il ln d d Φ o ra n m o r^■ d <Jl ^ι ω o o ι)l O O\ B σl O ιfl ^)l Ol '* (M <M ln (^,l d r- l)l m d r- Ol ln d « ^ι ^• ιJl O N O N » β Φ ( ln ι«ι <n ιn o ^ Φ f "l^, B * ln ln o π o d ιn <M Φ B in cM CD H c r i' cM i' c Λ o ι^,l n

n "J N a) o XoXoXoXoXoXoXoXoXoXoXoXoXoBoXoXoXoXoBXooX Xo oXoXoXoXoXoBoXoBoBoXoXoX oXoXoXoXoXoXoooo ^~o^"o^""o ooooooooooooooooooo_ oooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooo m co r- cn o CM ro -p m cD r- oo cn o H CM co ' in io r- oo cn o H CM co ' in io r- oo cn o H i" m co r- 00 CΛ O co " m co r- oo n O H m r~ oo cn ro r co co r co co ^, ι^{, ,} * ι^ι τ ^, ι ι^ι ' in ιn ιn ιn ιn ιn ιn ιn ιn ιn ιo cD co so Φ Φ r- r- r- i- r- r- r- r- 0000 0000 CO CO 00 o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o O O O o o o o o o o o o O O O O O O o o

00 o ooo o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o O O O o o o o o o o o o O O O o o o o o rH rH ri ri H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H εεεεεεεεaa εεεεaaεaaεaaaaaaaaaεεaaaaεεε ε ε ε ε ε H ε a a a a ε ε ε a a a a a a a a ε ε ε ε a a a ft tt tt tt tt tt < tt < ft ft tt < tt < < < < < ft ft < < < < ft < tt < < < < tt < < < tt ft ft < ftt rt tt < ft ft tt < _ rt! ft < & f << t _t! 1 f3t

H r ω w w w w w c_ w c_ w w w w ω w H W [_ _) W i-] ω w ω w ω w w ω w ω o P-l a a w w ω ω

X x a B a a a a a a — X X X X X X X X X X X rC X 3C X X X X X X X X X X X P— ! rQ X X a a a a x x x a a a a a a a a a a x x it

TabU S

HETATM10090 0 HOH 8244 75.191 -15.210 1.700 00 34 .77 O HETATM10091 O HOH 8245 51.102 7.512 -30.877 00 39. 35 O HETATM10092 0 HOH 8246 29.649 40.776 11.607 00 36.74 O HETATM10093 O HOH 8247 64.241 -11.167 31.991 00 36. 77 O HETATM10094 O HOH 8248 35.807 52.227 -37.837 00 42 . 89 O HETATM10095 O HOH 8249 21.004 47.633 -18.472 00 43. 58 O HETATM10096 O HOH 8250 20.104 21.077 -27.523 00 37 .70 O HETATM10097 0 HOH 8251 82.131 -14.102 -15.373 00 46. 38 O HETATM10098 O HOH 8252 52.596 316 -10.214 00 33. 07 O HETATM10099 0 HOH 8253 54.192 046 30.601 00 35. 61 O HETATM10100 O HOH 8254 28.240 44.984 -53.215 00 30. 80 O HETATM10101 o HOH 8255 64.550 -3.466 -2.475 00 37 . 95 O HETATM10102 o HOH 8256 16.260 21.918 -28.169 00 42 .28 O HETATM10103 o HOH 8257 31.591 44.914 17.918 00 30. 56 O HETATM10104 o HOH 8258 63.725 18.485 -36.455 00 41 . 83 O HETATM10105 o HOH 8259 54.594 4.317 -30.127 00 36. 36 O HETATM10106 o HOH 8260 12.031 48.610 15.939 00 34 . 32 O HETATM10107 o HOH 8261 62.047 0.039 1.306 00 40 . 89 O HETATM10108 o HOH 8262 63.743 26.826 40.506 00 38 . 51 O HεTATM10109 o HOH 8263 80.317 -12.708 5.435 00 35.75 O

CONECT 4172 4569

CONECT 4569 4172

CONECT 4893 5256

CONECT 5256 4893

CONECT 5615 6015

CONECT 6015 5615

CONECT 6356 6708

CONECT 6708 6356

CONECT 7044 7433

CONECT 7433 7044

CONECT 7784 8177

CONECT 8177 7784

CONECT 8549 8942

CONECT 8942 8549

CONECT 9289 9675

CONECT 9675 9289

CONECT 9827 9828 9829 9830 9831

CONECT 9828 9827

CONECT 9829 9827

CONECT 9830 9827

CONECT 9831 9827

CONECT 9832 9833 9834 9835 9836

CONECT 9833 9832

CONECT 9834 9832

CONECT 9835 9832

CONECT 9836 9832

CONECT 9837 9838 9839 9840 9841

CONECT 9838 9837

CONECT 9839 9837

CONECT 9840 9837

CONECT 9841 9837

CONECT 9842 9843 9844 9845 9846

CONECT 9843 9842

CONECT 9844 9842

CONECT 9845 9842

CONECT 9846 9842

MASTER 540 0 4 24 123 0 0 610101 8 36 112 Table 4

Table 4 Stem Cell Factor Dimer

HEADER HORMONE/GROWTH FACTOR 05-MAY-00 1EXZ

TITLE STRUCTURE OF STEM CELL FACTOR

COMPND MOL_ID: 1;

COMPND 2 MOLECULE: STEM CELL FACTOR;

COMPND 3 CHAIN: A, B, C, D;

COMPND 4 FRAGMENT: 26-166;

COMPND 5 SYNONYM: SCF;

COMPND 6 ENGINEERED: YES

SOURCE MOL_ID: 1;

SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;

SOURCE 3 ORGANISM_COMMON: HUMAN;

SOURCE 4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;

SOURCE 5 EXPRESSION_SYSTEM_COMMON: BACTERIA

KEYWDS SCF

EXPDTA X-RAY DIFFRACTION

AUTHOR Z . ZHANG, R. ZHANG,A. JOACHIMIAK, J. SCHLESSINGER, X. KONG

REVDAT 1 06-JUL-00 1EXZ 0

JRNL AUTH Z . ZHANG, R. ZHANG, A. JOACHIMIAK, J. SCHLESSINGER, X . KONG

JRNL TITL CRYSTAL STRUCTURE OF HUMAN STEM CELL FACTOR:

JRNL TITL 2 IMPLICATION FOR STEM CELL FACTOR RECEPTOR

JRNL TITL 3 DIMERIZATION AND ACTIVATION.

JRNL REF PROC. NAT.ACAD. SCI. USA V. 97 7732 2000

JRNL REFN ASTM PNASA6 US ISSN 0027-8424

REMARK 1

REMARK 2

REMARK 2 RESOLUTION. 2.30 ANGSTROMS.

REMARK 3

REMARK 3 REFINEMENT.

REMARK 3 PROGRAM CNS

REMARK 3 AUTHORS BRUNGER, ADAMS, CLORE, DELANO, GROS, GROSSE-

REMARK 3 KUNSTLEVE, JIANG, KUSZEWSKI , ILGES, PANNU,

REMARK 3 READ, RICE, SIMONSON, ARREN

REMARK 3

REMARK 3 REFINEMENT TARGET : MLF

REMARK 3

REMARK 3 DATA USED IN REFINEMENT.

REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) 2.30

REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) 40.00

REMARK 3 DATA CUTOFF (SIGMA(F)) 2.000

REMARK 3 OUTLIER CUTOFF HIGH (RMS (ABS (F) ) ) NULL

REMARK 3 COMPLETENESS (WORKING+TEST) (%) 10.0

REMARK 3 NUMBER OF REFLECTIONS 21494

REMARK 3

REMARK 3

REMARK 3 FIT TO DATA USED IN REFINEMENT.

REMARK 3 CROSS-VALIDATION METHOD NULL

REMARK 3 FREE R VALUE TEST SET SELECTION RANDOMLY SELECTED 10%

REMARK 3 OF REFLECTIONS

REMARK 3 R VALUE (WORKING SET) 0.223

REMARK 3 FREE R VALUE 0.294

REMARK 3 FREE R VALUE TEST SET SIZE (%) NULL

REMARK 3 FREE R VALUE TEST SET COUNT 2133

REMARK 3 ESTIMATED ERROR OF FREE R VALUE NULL Table 4

REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3 TOTAL NUMBER OF BINS USED NULL REMARK 3 BIN RESOLUTION RANGE HIGH (A) NULL REMARK 3 BIN RESOLUTION RANGE LOW (A) NULL REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) NULL REMARK 3 REFLECTIONS IN BIN (WORKING SET) NULL REMARK 3 BIN R VALUE (WORKING SET) NULL REMARK 3 BIN FREE R VALUE NULL REMARK 3 BIN FREE R VALUE TEST SET SIZE (%) NULL REMARK 3 BIN FREE R VALUE TEST SET COUNT NULL REMARK 3 ESTIMATED ERROR OF BIN FREE R VALUE NULL REMARK 3 REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3 PROTEIN ATOMS 4090 REMARK 3 NUCLEIC ACID ATOMS 0 REMARK 3 HETEROGEN ATOMS 14 REMARK 3 SOLVENT ATOMS 132 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) 45.00 REMARK 3 MEAN B VALUE (OVERALL, A**2) NULL REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 Bll (A**2) NULL REMARK 3 B22 (A**2) NULL REMARK 3 B33 (A**2) NULL REMARK 3 B12 (A**2) NULL REMARK 3 B13 (A**2) NULL REMARK 3 B23 (A**2) NULL REMARK 3 REMARK 3 ESTIMATED COORDINATE ERROR. REMARK 3 ESD FROM LUZZATI PLOT (A) NULL REMARK 3 ESD FROM SIGMAA (A) NULL REMARK 3 LOW RESOLUTION CUTOFF (A) NULL REMARK 3 REMARK 3 CROSS-VALIDATED ESTIMATED COORDINATE ERROR. REMARK 3 ESD FROM C-V LUZZATI PLOT (A) NULL REMARK 3 ESD FROM C-V SIGMAA (A) NULL REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES. REMARK 3 BOND LENGTHS (A) 0.007 REMARK 3 BOND ANGLES (DEGREES) 1.22 REMARK 3 DIHEDRAL ANGLES (DEGREES) NULL REMARK 3 IMPROPER ANGLES (DEGREES) NULL REMARK 3 REMARK 3 ISOTROPIC THERMAL MODEL NULL REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRA AIINNTTSS.. RMS SIGMA REMARK 3 MAIN-CHAIN BOND (A**2) NULL NULL REMARK 3 MAIN-CHAIN ANGLE (A**2) NULL ^• NULL REMARK 3 SIDE-CHAIN BOND (A**2) NULL ^• NULL REMARK 3 SIDE-CHAIN ANGLE (A**2) NULL NULL REMARK 3 REMARK 3 REMARK 3 BULK SOLVENT MODELING. REMARK 3 METHOD USED : NULL REMARK 3 KSOL : NULL REMARK 3 BSOL : NULL REMARK 3 Table 4

REMARK 3 NCS MODEL : NULL

REMARK 3

REMARK 3 NCS RESTRAINTS. RMS SIGMA/WEIGHT

REMARK 3 GROUP 1 POSITIONAL (A) : NULL ; NULL

REMARK 3 GROUP 1 B-FACTOR (A**2) : NULL ; NULL

REMARK 3

REMARK 3 PARAMETER FILE 1 : NULL

REMARK 3 TOPOLOGY FILE 1 : NULL

REMARK 3

REMARK 3 OTHER REFINEMENT REMARKS: MAXIMUM LIKELIHOOD TARGET USING

REMARK 3 AMPLITUDES

REMARK

REMARK 4 1EXZ COMPLIES WITH FORMAT V. 2.3, 09-JULY-1998

REMARK 100

REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 12-MAY-2000.

REMARK 100 THE RCSB ID CODE IS RCSB011008.

REMARK 200

REMARK 200 EXPERIMENTAL DETAILS

REMARK 200 EXPERIMENT TYPE X-RAY DIFFRACTION

REMARK 200 DATE OF DATA COLLECTION 26-NOV-1999

REMARK 200 TEMPERATURE (KELVIN) 100.0

REMARK 200 PH 7.00

REMARK 200 NUMBER OF CRYSTALS USED 1

REMARK 200

REMARK 200 SYNCHROTRON (Y/N) Y; Y

REMARK 200 RADIATION SOURCE APS ; APS

REMARK 200 BEAM INE 19ID; 19ID

REMARK 200 X-RAY GENERATOR MODEL NULL

REMARK 200 MONOCHROMATIC OR LAUE (M/L) M

REMARK 200 WAVELENGTH OR RANGE (A) 1.03; 1.55

REMARK 200 MONOCHROMATOR NULL

REMARK 200 OPTICS NULL

REMARK 200

REMARK 200 DETECTOR TYPE CCD

REMARK 200 DETECTOR MANUFACTURER BRANDEIS

REMARK 200 INTENSITY-INTEGRATION SOFTWARE DENZO

REMARK 200 DATA SCALING SOFTWARE SCALEPACK

REMARK 200

REMARK 200 NUMBER OF UNIQUE REFLECTIONS 21454

REMARK 200 RESOLUTION RANGE HIGH (A) 2.300

REMARK 200 RESOLUTION RANGE LOW (A) 40.000

REMARK 200 REJECTION CRITERIA (SIGMA(I) ) 2.000

REMARK 200

REMARK 200 OVERALL.

REMARK 200 COMPLETENESS FOR RANGE (%) 99.5

REMARK 200 DATA REDUNDANCY 8.000

REMARK 200 R MERGE (I) 0.05800

REMARK 200 R SYM (I) NULL

REMARK 200 <I/SIGMA(I)> FOR THE DATA SET 29.0000

REMARK 200

REMARK 200 IN THE HIGHEST RESOLUTION SHELL.

REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) 2.30

REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) 2.38

REMARK 200 COMPLETENESS FOR SHELL (%) 90.1

REMARK 200 DATA REDUNDANCY IN SHELL 7.00

REMARK 200 R MERGE FOR SHELL (I) 0.25000

REMARK 200 R SYM FOR SHELL (I) NULL

REMARK 200 <I/SIGMA(I)> FOR SHELL NULL

REMARK 200 TabU'4

REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: NULL REMARK 200 SOFTWARE USED: PHASES REMARK 200 STARTING MODEL: NULL REMARK 200 REMARK 200 REMARK: NULL REMARK 280 REMARK 280 CRYSTAL REMARK 280 SOLVENT CONTENT, VS (%) : NULL REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA) : NULL REMARK 280 REMARK 280 CRYSTALLIZATION CONDITIONS: 28% PEG 400, 250 MM CACL2, 1 REMARK 280 MM SMCL3 REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1 REMARK 290 REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X,Y,Z REMARK 290 2555 -X,l/2+Y,-Z REMARK 290 REMARK 290 WHERE NNN -> OPERATOR NUMBER REMARK 290 MMM -> TRANSLATION VECTOR REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 2 0.000000 1.000000 0.000000 43.76300 REMARK 290 SMTRY3 2 0.000000 0.000000 -1.000000 0.00000 REMARK 290 REMARK 290 REMARK: NULL REMARK 300 REMARK 300 BIOMOLECULE: 1, 2 REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT REMARK 300 WHICH CONSISTS OF 4 CHAIN (S). SEE REMARK 350 FOR REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE (S). REMARK 350 REMARK 350 GENERATING THE BIOMOLECULE REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B REMARK 350 BIOMT1 1 1.000000 0.000000 0. 000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 350 BIOMOLECULE: 2 REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D REMARK 350 BIOMT1 2 1.000000 0.000000 0. 000000 0.00000 REMARK 350 BIOMT2 2 0.000000 1.000000 0.000000 0.00000 Table 4

REMARK 350 BIOMT3 2 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 GLU A 1 REMARK 465 GLY A 2 REMARK 465 ILE A 3 REMARK 465 GLU A 134 REMARK 465 THR A 135 REMARK 465 SER A 136 REMARK 465 VAL A 140 REMARK 465 SER A 141 REMARK 465 GLU B 201 REMARK 465 GLU C 401 REMARK 465 GLY C 402 REMARK 465 ILE C 403 REMARK 465 CYS C 404 REMARK 465 ARG C 405 REMARK 465 ASN C 406 REMARK 465 ARG C 407 REMARK 465 VAL C 408 REMARK 465 VAL C 540 REMARK 465 SER C 541 REMARK 465 GLU D 601 REMARK 465 GLY D 602 REMARK 465 ILE D 603 REMARK 465 CYS D 604 REMARK 465 ARG D 605 REMARK 465 ASN D 606 REMARK 465 ARG D 607 REMARK 465 VAL D 608 REMARK 465 SER D 733 REMARK 465 GLU D 734 REMARK 465 THR D 735 REMARK 465 SER D 736 REMARK 465 ASP D 737 REMARK 465 CYS D 738 REMARK 465 VAL D 739 REMARK 465 VAL D 740 REMARK 465 SER D 741 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE) : REMARK 470 M RES CSSEQI ATOMS REMARK 470 ARG 5 CG CD NE CZ NHl NH2 REMARK 470 ARG 7 CG CD NE CZ NHl NH2 REMARK 470 ASN 10 CG ODl ND2 REMARK 470 GLU 292 CG CD OEl OE2 REMARK 470 ASN 293 CG ODl ND2 REMARK 470 SER 294 OG REMARK 470 SER 295 OG REMARK 470 LYS 296 CG CD CE NZ REMARK 470 ASP 297 CG ODl OD2 fable 4

REMARK 470 LEU B 298 CG CDl CD2 REMARK 470 LYS B 299 CG CD CE NZ REMARK 470 LYS B 300 CG CD CE NZ REMARK 470 SER B 301 OG REMARK 470 PHE B 302 CG CDl CD2 CEl CE2 CZ REMARK 470 LYS B 303 CG CD CE NZ REMARK 470 SER B 341 OG REMARK 470 ASN 410 CG ODl ND2 REMARK 470 LYS 413 CG CD CE NZ REMARK 470 LYS 491 CG CD CE NZ REMARK 470 GLU 492 CG CD OEl OE2 REMARK 470 ASN 493 CG ODl ND2 REMARK 470 SER 494 OG REMARK 470 SER 495 OG REMARK 470 LYS 496 CG CD CE NZ REMARK 470 ASP 497 CG ODl OD2 REMARK 470 LEU 498 CG CDl CD2 REMARK 470 LYS 499 CG CD CE NZ REMARK 470 LYS 500 CG CD CE NZ REMARK 470 SER 501 OG REMARK 470 PHE 502 CG CDl CD2 CEl CE2 CZ REMARK 470 LYS 696 CG CD CE NZ REMARK 470 LYS 699 CG CD CE NZ REMARK 470 LYS 700 CG CD CE NZ REMARK 470 SER 701 OG REMARK 470 PHE 702 CG CDl CD2 CEl CE2 CZ REMARK 470 LYS D 703 CG CD CE NZ REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI REMARK 500 SM SM C 801 O HOH 946 1.92 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS REMARK 500 REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC REMARK 500 SYMMETRY ARE IN CLOSE CONTACT. AN ATOM LOCATED WITHIN 0. 15 REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375 REMARK 500 INSTEAD OF REMARK 500. ATOMS WITH NON-BLANK ALTERNATE REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS. REMARK 500 REMARK 500 DISTANCE CUTOFF: REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI SSYMOP DISTANCE REMARK 500 OEl GLU D 713 SM SM B 803 2645 2.12 REMARK 500 OE2 GLU A 88 SM SM C 8*01 2656 2.17 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE Table 4

REMARK 500 THAN 6*RMSD <M=MODEL NUMBER; RES =RESIDUE NAME; C=CHAIN

REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER ; I=INSERTION CODE) .

REMARK 500

REMARK 500 STANDARD TABLE:

REMARK 500 FORMAT: (10X, 13, IX, 2 (A3, IX, Al, 14 ,A1,1X,A4,3X) ,F6.3)

REMARK 500

REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991

REMARK 500

REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION

REMARK 500 PRO A 23 CG PRO A 23 CB 0.046

REMARK 500 MET A 48 CE MET A 48 SD -0.081

REMARK 500 MET C 448 SD MET C 448 CG 0.040

REMARK 500 PRO C 512 CG PRO C 512 CB 0.058

REMARK 500

REMARK 500 GEOMETRY AND STEREOCHEMISTRY

REMARK 500 SUBTOPIC: COVALENT BOND ANGLES

REMARK 500

REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES

REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE

REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES =RESIDUE NAME; C=CHAIN

REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER ; I=INSERTION CODE) .

REMARK 500

REMARK 500 STANDARD TABLE:

REMARK 500 FORMAT: (10X, 13, IX,A3, IX, Al, 14,Al, 3 (IX,A4 , 2X) , 12X, F5.1)

REMARK 500

REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991

REMARK 500

REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3

REMARK 500 THR A 111 N - CA - C ANGL. DEV. = -7.7 DEGREES

REMARK 500 ARG A 117 N - CA - C ANGL. DEV. = -7.7 DEGREES

REMARK 500 PRO B 234 N - CA - C ANGL. DEV. = 10.2 DEGREES

REMARK 500 ILE B 245 N - CA - C ANGL. DEV. = 8.5 DEGREES

REMARK 500 ARG B 317 N - CA - C ANGL. DEV. = -8.0 DEGREES

REMARK 500 LYS C 413 N - CA - C ANGL. DEV. = -8.0 DEGREES

REMARK 500 ASP C 414 N - CA - C ANGL. DEV. = -8.4 DEGREES

REMARK 500 ASP C 437 N - CA - C ANGL. DEV. = 7.6 DEGREES

REMARK 500 TRP C 444 N - CA - C ANGL. DEV. = 10.9 DEGREES

REMARK 500 ILE C 445 N - CA - C ANGL. DEV. = 7.2 DEGREES

REMARK 500 ASP C 528 N - CA - C ANGL. DEV. = 11.9 DEGREES

REMARK 500 VAL C 530 N - CA - C ANGL. DEV. = 8.9 DEGREES

REMARK 500 THR D 711 N - CA - C ANGL. DEV. = -8.6 DEGREES

REMARK 500 ARG D 717 N - CA - C ANGL. DEV. = -8.1 DEGREES

REMARK 500

REMARK 500 GEOMETRY AND STEREOCHEMISTRY

REMARK 500 SUBTOPIC: TORSION ANGLES

REMARK 500

REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:

REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;

REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE) .

REMARK 500

REMARK 500 STANDARD TABLE:

REMARK 500 FORMAT: (10X, 13, IX,A3, IX,Al, 14 , Al ,4X,F7.2,3X,F7.2)

REMARK 500

REMARK 500 M RES CSSEQI PSI PHI

REMARK 500 SER A 101 104.88 120. 52

REMARK 500 PHE A 102 78.79 -100. 99

REMARK 500 PHE B 302 50.55 -96. 61

REMARK 500 PHE C 502 54.70 -95. 94

REMARK 500 ASP C 528 25.52 -113. 66 Table 4

REMARK 500 VAL C 530 33.44 113. .93

REMARK 500 ILE D 645 ( 51.98 -60. .00

DBREF 1EXZ A 1 141 SWS P21583 SCF HUMAN 26 166

DBREF 1EXZ B 201 341 SWS P21583 SCF HUMAN 26 166

DBREF 1EXZ C 401 541 SWS P21583 SCF_HUMAN 26 166

DBREF 1EXZ D 601 741 SWS P21583 SCF HUMAN 26 166

SEQRES 1 A 141 GLU GLY ILE CYS ARG ASN ARG VAL THR ASN ASN VAL LYS

SEQRES 2 A 141 ASP VAL THR LYS LEU VAL ALA ASN LEU PRO LYS ASP TYR

SEQRES 3 A 141 MET ILE THR LEU LYS TYR VAL PRO GLY MET ASP VAL LEU

SEQRES 4 A 141 PRO SER HIS CYS TRP ILE SER GLU MET VAL VAL GLN LEU

SEQRES 5 A 141 SER ASP SER LEU THR ASP LEU LEU ASP LYS PHE SER ASN

SEQRES 6 A 141 ILE SER GLU GLY LEU SER ASN TYR SER ILE ILE ASP LYS

SEQRES 7 A 141 LEU VAL ASN ILE VAL ASP ASP LEU VAL GLU CYS VAL LYS

SEQRES 8 A 141 GLU ASN SER SER LYS ASP LEU LYS LYS SER PHE LYS SER

SEQRES 9 A 141 PRO GLU PRO ARG LEU PHE THR PRO GLU GLU PHE PHE ARG

SEQRES 10 A 141 ILE PHE ASN ARG SER ILE ASP ALA PHE LYS ASP PHE VAL

SEQRES 11 A 141 VAL ALA SER GLU THR SER ASP CYS VAL VAL SER

SEQRES 1 B 141 GLU GLY ILE CYS ARG ASN ARG VAL THR ASN ASN VAL LYS

SEQRES 2 B 141 ASP VAL THR LYS LEU VAL ALA ASN LEU PRO LYS ASP TYR

SEQRES 3 B 141 MET ILE THR LEU LYS TYR VAL PRO GLY MET ASP VAL LEU

SEQRES 4 B 141 PRO SER HIS CYS TRP ILE SER GLU MET VAL VAL GLN LEU

SEQRES 5 B. 141 SER ASP SER LEU THR ASP LEU LEU ASP LYS PHE SER ASN

SEQRES 6 B 141 ILE SER GLU GLY LEU SER ASN TYR SER ILE ILE ASP LYS

SEQRES 7 B 141 LEU VAL ASN ILE VAL ASP ASP LEU VAL GLU CYS VAL LYS

SEQRES 8 B 141 GLU ASN SER SER LYS ASP LEU LYS LYS SER PHE LYS SER

SEQRES 9 B 141 PRO GLU PRO ARG LEU PHE THR PRO GLU GLU PHE PHE ARG

SEQRES 10 B 141 ILE PHE ASN ARG SER ILE ASP ALA PHE LYS ASP PHE VAL

SEQRES 11 B 141 VAL ALA SER GLU THR SER ASP CYS VAL VAL SER

SEQRES 1 C 141 GLU GLY ILE CYS ARG ASN ARG VAL THR ASN ASN VAL LYS

SEQRES 2 c 141 ASP VAL THR LYS LEU VAL ALA ASN LEU PRO LYS ASP TYR

SEQRES 3 c 141 MET ILE THR LEU LYS TYR VAL PRO GLY MET ASP VAL LEU

SEQRES 4 c 141 PRO SER HIS CYS TRP ILE SER GLU MET VAL VAL GLN LEU

SEQRES 5 c 141 SER ASP SER LEU THR ASP LEU LEU ASP LYS PHE SER ASN

SEQRES 6 c 141 ILE SER GLU GLY LEU SER ASN TYR SER ILE ILE ASP LYS

SEQRES 7 c 141 LEU VAL ASN ILE VAL ASP ASP LEU VAL GLU CYS VAL LYS

SEQRES 8 c 141 GLU ASN SER SER LYS ASP LEU LYS LYS SER PHE LYS SER

SEQRES 9 c 141 PRO GLU PRO ARG LEU PHE THR PRO GLU GLU PHE PHE ARG

SEQRES 10 c 141 ILE PHE ASN ARG SER ILE ASP ALA PHE LYS ASP PHE VAL

SEQRES 11 c 141 VAL ALA SER GLU THR SER ASP CYS VAL VAL SER

SEQRES 1 D 141 GLU GLY ILE CYS ARG ASN ARG VAL THR ASN ASN VAL LYS

SEQRES 2 D 141 ASP VAL THR LYS LEU VAL ALA ASN LEU PRO LYS ASP TYR

SEQRES 3 D 141 MET ILE THR LEU LYS TYR VAL PRO GLY MET ASP VAL LEU

SEQRES 4 D 141 PRO SER HIS CYS TRP ILE SER GLU MET VAL VAL GLN LEU

SEQRES 5 D 141 SER ASP SER LEU THR ASP LEU LEU ASP LYS PHE SER ASN

SEQRES 6 D 141 ILE SER GLU GLY LEU SER ASN TYR SER ILE ILE ASP LYS

SEQRES 7 D 141 LEU VAL ASN ILE VAL ASP ASP LEU VAL GLU CYS VAL LYS

SEQRES 8 D 141 GLU ASN SER SER LYS ASP LEU LYS LYS SER PHE LYS SER

SEQRES 9 D 141 PRO GLU PRO ARG LEU PHE THR PRO GLU GLU PHE PHE ARG

SEQRES 10 D 141 ILE PHE ASN ARG SER ILE ASP ALA PHE LYS ASP PHE VAL

SEQRES 11 D 141 VAL ALA SER GLU THR SER ASP CYS VAL VAL SER

HET SM C 801 1

HET SM 802 1

HET SM B 803 1

HET SM 804 1

HET CA C 805 1

HET CA A 806 1

HET TRS 807 8

HETNAM SM SAMARIUM (III) ION

HETNAM CA CALCIUM ION Table 4^'

HETNAM TRS 2- -AMINO- 2-HYDROXYMETHYI ,-PROPANE- ^■1, 3-DIOL

HETSYN TRS TRIS BUFFER

FORMUL 5 SM 4 (SMI 3+)

FORMUL 9 CA 2(CA1 2+)

FORMUL 11 TRS C4 H12 Nl 03 H

FORMUL 12 HOH *132(H2 01)

HELIX 1 1 ASN A 11 ASN A 21 1 11

HELIX 2 2 PRO A 40 CYS A 43 5 4

HELIX 3 3 TRP A 44 ASP A 61 1 18

HELIX 4 4 SER A 71 ASN A 93 1 23

HELIX 5 5 THR A 111 ASP A 128 1 18

HELIX 6 6 ASN B 211 ASN B 221 1 11

HELIX 7 7 PRO B 240 CYS B 243 5 4

HELIX 8 8 TRP B 244 ASP B 261 1 18

HELIX 9 9 SER B 271 VAL B 290 1 20

HELIX 10 10 THR B 311 ALA B 325 1 15

HELIX 11 11 LYS C 413 ASN C 421 1 9

HELIX 12 12 PRO C 440 CYS C 443 5 4

HELIX 13 13 TRP C 444 ASP C 461 1 18

HELIX 14 14 SER C 471 LYS C 491 1 21

HELIX 15 15 THR C 511 ALA C 525 1 15

HELIX 16 16 VAL D 612 ASN D 621 1 10

HELIX 17 17 ILE D 645 ASP D 661 1 17

HELIX 18 18 SER D 671 ASN D 693 1 23

HELIX 19 19 THR D 711 LYS D 727 1 17

SHEET 1 A 2 ILE A 28 TYR A 32 0

SHEET 2 A 2 GLU A 106 PHE A 110 -1 O GLU A 106 N TYR A 32

SHEET 1 B 2 ILE B 228 LYS B 231 0

SHEET 2 B 2 PRO B 307 PHE B 310 -1 O ARG B 308 N LEU B 230

SHEET 1 C 2 ILE C 428 LYS C 431 0

SHEET 2 C 2 PRO C 507 PHE C 510 -1 O ARG C 508 N LEU C 430

SHEET 1 D 2 ILE D 628 LYS D 631 0

SHEET 2 D 2 PRO D 707 PHE D 710 -1 N ARG D 708 O LEU D 630

SSBOND 1 CYS A 4 CYS A 89

SSBOND 2 CYS A 43 CYS A 138

SSBOND 3 CYS B 204 CYS B 289

SSBOND 4 CYS B 243 CYS B 338

SSBOND 5 CYS C 443 CYS C 538

LINK SM SM B 803 OD2 ASP B 337

CRYST 1 36.154 87.526 79.. 134 90. 00 97 .76 i 90.00 P 1 21 1

ORIGX1 1.000000 0 .000000 0. 000000 0.00000

ORIGX2 0.000000 1 .000000 0. 000000 0.00000

ORIGX3 0.000000 0 .000000 1. 000000 0.00000

SCALE1 0.027659 0 .000000 0. 003769 0.00000

SCALE2 0.000000 0 .011425 0. 000000 0.00000

SCALE3 0.000000 0 .000000 0. 012705 0.00000 z ϋuounzuuouz uuouuoz zuu ouzuυouuuz uuou oϋz u uou g uu o uu oz zu uou uuz u u

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH

CΛ ro iO i- r- iD co o ro vo ii cΛ vo r- vo H <n H n m cM θ oo cM H co mo oo H cn ι cn cM in oo oo co co m ι oo oo r- CM CM r~ oo oo OCO O H Ii H O in O O CO ^, (θ ιn ιn coo ^, t- ι^, oo oo ιθ o H ιn o ' l H r~ ^, r- H 001' r- c^ co H • 1" o • σ^ 1<n ιo m o o ' C ' H ι H 1 _^ ^,• oocM vo H ro H r- co co cg r- oo oo com cDr- r- - ' r- oo ooocoin oor- ιnooocDcocMr- ι cM < Hro cM CM cn<M oo ω cMinιnιncM t- H roocθH (o cn ιtc <nnoooi" inr '3^, HCo o cM σι

CM CM CM H H H CO COCM H ' CM O cn cn o cn CO O OO r- CO in i^ CO m 'J' CO ' CO in ' ' CM H ' m cOCM H O O H o cn oo o cM CM <o oo r~ cD m r~ co oo r- co i ιn ι ι ιn ιn ι ιn ιn ι ιn ιn ι ιn 'j' i ^{, ,} ιn ^, ι^, ι^, ι^, ' ι ι ι ι^, ι^{, , 4} ι^, ιι ι^{, , ,} ι^{ι ι} ι^ι f io o ' i' ' ' co ro ro co co co co rororo

Φ lOIΛ d n ri « r^> M ONmo ΓM ιn Φ lΛ β co ιn ιnιnιn

< tt ft < tt < < tt < < ft < < ft < < tt tt *t < ft < < < < tt < tt < < < < < < < < < tt tt < < < tt tt < tt tt tt < < tt < < < tt

??????i5-9--^{z zz} zzz uuϋuuuSSa?3rt rt rt (no rt ω zuoooωzuuoo rt o Ω a tt ca rt m o o < ω o o < ft CQ O Q Q ft 0Q (-⁾ C_ < zoo oo υ o z z o o o o z u u o u u u z υoo υo u z υ υ o o zυuooυozzoυoυυυz υ o ι^»l "l^, lnΦ ωal O H ιn ιr) Cθ co

00 rH VO a a ε a a a a ε s a ε a a a a a ε S S 2

© O O O O O O O O O O O O O O O o δδ δ δ o o o o o o o o o o o o o O O O s os o s o os o o o o o o o H H ft ft ft < ft < & tt f s f ft & < ft ft s ft & ft rt rt rt rt ft ft rt rt rt rt < rt < ft rt rt rt rt rt rt rt rt rt rt rt rt rt rt it

o oυ υo z zo uoou o o z υ υ ooυo z o o o o o u z u υo u o υoz z υ υ o uo υϋ z u υooυ u z υ υ oυ zoυ o u υ

o

CΛ r- ro t- ' O ro c cM io m cD ro cM O io o cM H H r- ^, co ι< CM r~ cΛ CΛ CM ro o oo θ H θ co oo cn cM ro ιn H oo oo i' r~ H r- ιn co o ^| θ o θ ι~ ι r~ co H θ

H m H — > r- co o cΛ VD m ^, _^, oo r oo r- ιn cn ro cM CM θ H co r~ co cD in H oo ιn H oo cτ) r-- r~ co vθ H θ r-- oo ιn H θ ιn oo cD oo cM θ θ CM r- VD σι cM cn oo CJ

^Q. N ^_l) _Ol O O lI_l Φ O B O Ol <^ » N ι)l O\ o <_{f d} d _d W ι^,l o n n ^ι f) B d n ιl) l'^ o oO ll) n r• co ι^,ι ιn ^ ^ N ^^,l ^ » o o ιJ> co cIι ^ o □ <ι' ιn ιn ιn ιn ιo co ιι ιi 'r co ιn ιn ιn ιn co c co cM CM ro cM co co c co co co co co co c co co ' ' «* ^, co cM CM CM CM Ci cM CM CM CM c>ι ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

( m Φ ιn ^» ιn 1» n ln n m H n Φ lΛ ιn B N lIl ι ιn ι^,) d M ι» « ι»l ιn ιn ιn m n c^ ιJl o ln n w ιn ln o ι^,l ^ O "» Φ ιJl o\ σι d flo ^ι' O ll! c^ι O (l O d r" l!l ιJι llι » 'ιι n ι^,l U) » ιr) ^ ιn ιn ^ ιn d ^ ιo H Pl Φ ιI^ d lD « ^ιι O "l^l o ι!ι o d ^ ^ d d Λ a ^o » oι) «l ri ^ ^ N ιrl n d B O ^ n o * N d m n κl B ιΛ β « o m m ^ι ^ d ι n ι>ι o^ ιIl O B σl ^ o B σι Φ o ^ Φ r• N ιn v N ιn O ln M ^ ιn Φ B M ι)l « N O Ol ιn l d Ol d n Λ ι»ι ^ B lI> σι ιn <^ ( N » ιn ιo » "l^, N d ι "r ι<l ^ι o ()l N <l^, d o m m ^ oι ω ol ^ Φ C m ^ o m d B lIl lll (Λ o O ln ι^,l ιn f l»l Pl "l^ι n co co co ro co ro c ro co co co co ro c co co co co co ro co ro co ro cM co co co co cM CM Ci CM CM CM Cvi CM CM CM CM CM ro cM co c^ m oi B h r- ro iii d d V ffl B iη ^ B ^ d l~ PI N O O (M- Mi MΛ l u Φ O W O lΛ llHO M»I V ri Λ t" O « <f d MΛ θ r" O lll l' l d 01 ιr Λ lD O « U⁾ « β W M oc cMθcooco<Mooι co H H θ θ3C_ oιncDin H cooθ "- oooco r~ H iθ [_^ <n ( ιn ι co ' 'r r~ σι θ ιn oo C ocM ι-~ 'i^,<ncMoo CM CO CO VD CΛ CO CΛ OO m M_M inoMo in ιnHinn uι ι»ιo r) "i^ι ^ ( -) f d θ\ v BB θM)M» MJi"i^ι raw ι» M_^ o ιn piB (M Φ σnr( ooi 9 ffl ro oo oo cn o H CM cn o o o cM CM CM co o cn oo oo cn co o r-- vD io co ιn M co cM oo r— ~ io O in c^ _> _ r~ _ in oo cn o o o cn co <_Φ i^, ι ιn ι ιn ιι _t m m _ι ιn ι ur) in ι ι "-ι m -i' -_f ι ι_* -r t— oo n oo cn cn o H H cn o cn cn H C ι ιn ιn ιn ιn ι^ι ι ιn ιn m ι 'r ι^, 'j ι ι^, ι ιi 'ϊ^{, ,} ι ^, ι ^, ιn ι ιn ι

) n ⁽) n m n '^ >J 1^| ^ "» "l' "l' τf ln ιrι ιn ln ln lιlln Φ Φ Φ ^ ^ ^ ^ ^• BB ω<Il σl m σιOl lΛ<Il o o o o o d d d

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM tt < < < < < < < < < < < < ft < ft < < < < tt < < < < < < < < < ft < tt t < tt < ft < < f tt tt o] nw w ιnm ftι i- α_l [iι iiι tiι tt< Hi h ιj j j _hj _hj o; ιι; OC tf βi BJ oG W OT CO OT W CO CO CO CO D D D D D O O O Z Z Z Z Z Z >H >H >H H H H « o r^j M w cn OT rt rt rt rt rt rt rt X X x x x x x ^ ^ ^ ^ ^ ^ jH^^ ω ω w w ω ω ω c- ₎_| ₁l _f-| ^ ₁_l rt rt rt rt rt rt rt rt > > > > > > > H EH tl H tl r tH tH j J J J hH lH Hl J Hl J lH a J J j Hl £ >, - >S ^ < ^ < rt rt rt rt rt rt

H CM H CM H CM H CM H CM m Q w N rt ω - oo rt co n o rt CQ rt m o o o o o o z z uoouυooz o u o υ υ j z < υtυo nυUυQυoH Mz zuoo ffl n υ υ o CυQ OoCu3z f oooQQuz fotooυuυuu < z o u o u z o o o u o

N c fl^ι ι Φ ^ B Ol O d ι (^»ι » ln Φ ^ m (n o d N ( τ ιn ^ Cl O d N m 9 ιn B o^ o N n fl ιn Φ B m o O H CM o i i cD [~ oo o H C r i vo co cD to co ιo co ιo r~ r- ι-- r~ r~ r~ r- r~ r-- r-- oo o3 oo co oo oo oo ∞ α5 oo <n <n σι cn <n σ CΛ cn cn cn o o o o o o o o o o H -^■ — " -I H H H H H H H CM CM CM CM CM

H HH H HHHH H HH

00 rH VO aooaooaaoosoaoaoaoεεooεoBεoaoaoaooaaooaoaoaεoaooε oaaooaoaosaoaoaoaooaoaao oaaoaoaoaa ooaoaoaoaosoaoaa

© oεa ooaoa o a ε a a a a s a a o o o o o o o o o

O ft ft ft tt ft ft ft ft ft ft ft ft ft < < ft ft ft ft ft ft < ft ft ft rtrtrtrtrtrtrtrtrtrtrtrt ft ft ft ft ft ft ft ft ft ft ft ft ft tt ft ft ft ft ft ft < < ft rt rt it

ozzuυoυυoozouooo υzuoou o uυz z oυouoooz υooυooooυυo zυυooowozυuoooouz

ro JM 35

H in m σi co oo co r- H o o co moo CM CM H -r r- co o in o σ> o co ^, ι o n cD θ H N ro oo r- oo H r- H r- H m i H θ "!<^, H <n cM in H vo r- r- O H Co oo co co p- ro m - H CM in vo co oo m o ro H i o cn co oo o cM cn co H VD co ιn cM co ιn r-- o cn θ 'j' Co CJ m r- oo v co o m i- co i" o o > r~ > H r

CM T in co i co in H ro cM CM in co t— ι^, ι r~ ^, t~ o o o o ' ro r— O <o c H in cD i~ ro ιn ro ιn < vo ιn r~ oo ιn ιn ιo ιn oo o ιn ι cM CΛ co co r- CM c_ cn r~

CO C CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CO CO CO CO rO ro co ro cO co ro co co ro ro ro co ro ro ro ro ro co ro co co co ro ro ro ' i' ' co cM CM CM CM CM CM H CM ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

d 05l (Λ ^ N ^O l/) Φ o π <!l « ιJι ^ ffl N r^ d o ^^ ιn ln o v n N n ^ d M ln (M ^■ ϊι Φ Φ ^ ι <Iι ι^ ffl ι^,) (η f^ o ιIl « ^ « Φ lIι ^ n m n ι o ^ ln d o ^" π ι«ι ^ n o ^ <ι' ^ Φ lrl "ι^ι "r N "^ O N Φ ι») l N d ι^,l B » (^^ oι <Jl ^ r• ιM o ol ι o ιn B N » <ι^ ^ Φ ^ Ol ιn ιn n ιJl Λ ι O <ι^l ιrι ln B ln d m fl N d d ιn r" l ι^ ^ o ιn o^ lM ιn o B N < B d n ( ln ln o l 1' N d "l' « Φ ln ι'l l N V N N »

N

CM

O l~ H ιn ' CM IΛ C0 'r ^ r0 CM C H in O O <yι ιn H 00 CM CM O CM σ> W ιn H H H 00 C^ H CM CM ιn 000D <Tl in H C_ 1' H H 1 r~ CO l_> ιn ι C01" CD CM O 00 H CM H r- i* o oo 'y ι ιn o o ι 'r <n H VD oo 1' σ σ l~ 0 ^, ιO "- ιo c r~ ιn r^ σ H ιn o H ^-- oo o c oo 1 ιn c o ^- vo o r co oo co σι < H co ^D H C O H co o o co

B "r in θ 0l ω (0 N N » 51 IΛ 9 O d <3' m M π "r d Φ O M O M I») MΛ lΛ O Φ N 01 d l^,) * rⁱ ω N m fl B <Ii σι oo cn H cn cn m o oo r~ O H H CM cn co r- r~ αo o o vD in m in co co H ιn co r-- oo ιn co r-• co oo σl c o c C 1• ( CO O O H CM O oo p- r~ H M C H cM co H •1• CO i 'r i in i iⁱ in in in in i' ' i 'r ι ι^, ι^{, ,} ι ⁱ 'r ι ιn tn ιn ιn ιn ιn ιn ιn ι ιn ιn ιn ιn i' ^, ι ιn ιn ιn tn ι ιn ιθ ιo n d ι nl α! β ιn il H CΛ iι

ι w ⁾ c^J ⁽^ι c^ι ⁽ι ^ι 0ι ^η ⁽η ^{( (η} f^ l ^^ "ι^{, ,}ff ^,B' ^ ^ "ι^, "^^, ^^, ^ ιo ^n ιn ιfl ι) ιn ιo ιn Φ Φ Φ Φ Φ Φ Φ ^ ^ ^ ^ r ^^,' ^ B ω ω o x <π ^ft < < < < < tt < < < < < tt tt < ft < < < < < tt < < < < ft tt < ft tt < < < < tt < < < ft < < tt < < < < ft < tt < < tt < < tt

ZZ D DD O DD D DOOOOOOOW EH ω ω ω ω ω ω cd ω cc; c w w w i vi w tn JωJωiJωJj Hl«DiM⁽-;χ-cl--;^{O- X X X u ui Vϊ Vi

^n w^ ω^ωJ -;atl5iXlli>J^H w

A A A A rΛ +l A tt tt tt A ft tt f a w a ω a w a w ε ft -Qo α α ω ω isia < in oo ω tt m o - Q z u υo u ooυooooz υo oυ ow uz ooo u ooo in co t— oo cΛ θ H CM co ιι ιn vD r~ oo cn o <M < 1• ιn ιo t~ oo c^ι o H M C 1 ιn _ ^-- c» _ O H C c « ι co r~ oo o^ o H c "- ιn vo ^- oo n o H M r "-^, ιn cD p- CM CM CM CM CM co ro ro co co co co ro ro ro i' ι ^{, , ,} 'τ ιⁱ "^ ι^, ιn ιn ιn ιn ιn ιn ιn ιn ι ιn cD o co vo cD vo co co cD r- r-_' r^ r^ ι^ r^ [^ ι^ r^ r* oo co co co oo oo oo oo

εoaaaa aa oεεoaoaoaoaoεooε aoaooa oεεooε ooooooooooooooooooooooooooo

O ft < tt ft < < < < < < tt ft < < < < < < < ft < < < < < < < < tt < < < ft <

uuouoozυυoυuoozoooooυozzooouυooυυc ozυoocjoozυυoooozυuozυooυυwυzυ

_"* r^» ro

H <n n iD iθ ιn H i^, r- H θo ιn co ιn cM CD CD θ H in cM cD io oo H co ιn ro co co vo ι- cθ H cn r~ oo o ro H H ιn co o ιn cM CM oo θ f ro cM θ co cD θ co o ι o υ H t- cn ro in oo H co vO H co H c>i H θ ro co ι^, oo co ιn H co cD <o co co r~ r- o co cn ιn cM θ ^, CD CM r~ ι^, ro o ro cM co oo H r~ oo o θ ιn cD θ ^ι σι co ιn H o r- cD CM r— CM Co r— <x> r.- ι -^, -' CM H θ H H o o cM r- H θo ro co ι m co cD io r- <n r~ cΛ cn ι ιo cn σ> m ιn ιo <M ro i' ιn «τ co ro ι^, in i' Co r-. oo r- r- O H Oo cn o CO CM CM ΓO C ΓO CM CM CM CCMM CCMM CCMM CM CM ro ro co ro co co <o ^, ' CO co ro ro ro co co co ro co ro ro ro co co ro ro ro ro ^l i' i^, i^, i i' "- ^, i 1i 1i i 1ⁱ i "- in i iⁱ 1 in

O O O O OO O O OO OO O O Oι o_J o_i (o_t o_» o—i ιo-> o_ o_ o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o OO O O OO OOOOO O OO OO O OOOO O O oooooooooooooooo oooooooooooooooooooooooo

H H H H H H

I CO CM t- CM CM lM o

O H CM ro < c φ ^l N d H N oo ri H v (η o Λ ^o ι/l ⁽Λ σl oι H m ^ βl ^ o ^ oo ^• tf ^^ ^^• o « p> ^n ffl V ^ n Pl O ιJl ιO ^ O (β H O H O M ^η ^^,,) O H "l' n ^ n m d ιs m σι ω t^ ι ln o ln 9 d "» 1> m ι Λ n ιn n Φ O ιfl ι ιn (O Φ n ^l (1 d d O ln N N d d n Φ d ^ι m N Φ Ol B O * ln σ^ 1n N ln lO ιn r- n ι^> ^ « o ^o (n d o o 0 ^ι o ^ O "^ n H Φ P1 αι ^ ^ ^ ι)l (»l d ^ n ^O d co ^ φ ιo d n Ol ^D co « o oι ln Φ ^ o π ^ι Φ U Ol ιl) n Φ ^ o n ln d in

"^ » ιn ln ιn ιn n ^^ » n n π "^ d ι ^ "ι^| 1» ^ B Ol O N H d O ιJl B B ^ ^ ιι! ln d o ιll l^l d n « o o B B ffi O lIι Φ ιn Φ lD Λ ιn ^ ι» » n o ι ιn ι ι ι ι ι ιn ιn ιn ιθ ιn ι ιn ι ι ιn ιn ιn ιn ιn ιn iD ιo ιn ιn ιn ιn 'H ι '^ "- ^, ι ιn ι ι ι⁴ ι n ι "- ^, ' 'r "^ ι ι ' i* ^, 'r ι 'r ι^, ιi '^ oo oo * co r- CD C θΛ H θ ιn n cD i ιo ^, < r- ' ιn oo c H r~ 'r ιn n cx> cD c H CD ιn 'r ι > CM c i' co r~ r^ r~ C o ιn oo iD H r cD i cM θ cn r- ιn i'

ID H H m H θ 'r ⁽ ro r- <M CM -> CM co cM co H CM H 'r cn o ιn r H CM ro r~ r-- cM CM θo r"- o o Λ r- co o co cΛ cθ H θ <n cn cD <n co ' in cM iθ H θ oo oo r~ ^ co n r- H in co cD co co cM in 'r cΛ H c~ CM iθ H CM r~ a3 θ^ co ιn r- oo ιn cM co o ro o oo θM co o cM cn c~ ιn ro oo co r- CM Co ιⁱ H σι ι^, o co cM Vθ ι ιn o cM co ir) ^, r- r- co iD iD r~ oo in in i i r~ m co oo cn o o o o oo oo cΛ θ oo oo r-. cn r~ <n oo r- oo σι o σι oo cn oo H H H H co co cM H o cn cn oo r~ co m vo ιn ι^ι CM r~ cD ro fo co c co co co ro ro ro co fo co c co ro ro m ro ^, ι^, τ τ co co n ι^, co ro co co co co co co co ro ' ro co ro ro ι ι^l "- ι ι ι i iⁱ ro ro ro ro ro ro co co co co c co

Cn cn cn cn CΛ cn o O O O O O O O H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CO CO r C r CO CO 'T 'r 'r 'r i^, 1^, 1' ιn ιn ιn ιO CO lO lO CO CO CO CO CO r-- r-

CM CM CM cM CM CM ro co ro io ro ro ro co ro fO c co co co co co co co co co co co co co co co co co co co co co ro ro ro co

< < < < ^ft < < < < ^ft ^ft < < < < ^ft < ^ft ^ft < < ft < < ft < ^ft ft < < ft < < < ft < < ft ft < ft ft < ft < < ft < ft < ft

D D D D D D D D W W W O OT OT O OT rt rt pS tf crJ cή X pci flS Λ oS ciή Hl rl 0 0 0 0 0 0 0 H 4 H >H EH EH EH EH H EH EH EH C-, a4 uaauωwuiuιxxxxxxxxxxxχxxxχχxxχχft< Λ l- K l- Λ lϊ K J J J J B W W W iil H H H W O) hl HU J J J ^[J J ιJ J J J J J tJ i μi H H ι H EH t tι Eι H Eι tι Eι > > (_c_ <aι(-<(-ιi_ι _ι _ι _ι aaaaεaasrtrt oou D Uu^QwUυz rtc lJl O IM ⁽11 l/⁾ B ι)l o

B tl⁾ 01 Cl Φ 01 l⁾I IIl Λ 1^l « ιn H H H H H H H H H

SO rH VC aaεa

© oooooaoεoaoaεoεooεεooaoaaoaoεoaooaaoaoεooεεooaaoεoεoεoaoaoεooaoaoεaoaoεo ε OOaaOOaεOOaOaOaaOOεOεaOOaOaaOaOεOaOOsεOaOOaOεOεεO

O tt tt tt ft tt < ft ft < tt tt < < tt < ft tt ft < < < < ft < tt < < tt < < < tt < tt ft tt < ft tt tt tt < < tt tt ft tt tt < < < < < < < <

u o u u o o z o υ o υ υ υz υuo υ υo o z uuoooυ zoo ou o z υ u oo o z o o z z uuo o OT Z o υ o u u υ o z υ υ o u

ro 3_

H o o <M <Λ oo v oo ιn o r~ <Λ o v r~ ι~ * v co r~ * o ι w H '* θ H ( θ» ιn oθ ιH Λ <Λ o <Λ p" r~ c * ι^ o Λ in Λ r~ oo ιn ιo co <M θ in ιn vo H Cιi ιn H υ Λ ln Mll ιn N Φ 0\ ^ O (M f^ ι^ » n ln σι ιn σl O B O d O d ιIl n ιΛ ^ O (^,) B σ) N <n ι«) ^ ι» m B ^ o Λ B O m d lJι <n

O H H < r ii m r~ cD ii in r^ in in in in ro in r- cn in in in r~ oo in -r D o co o H m vo r~ r oo oo cΛ <n r~ ^, ιn H ' CM θ r- H cn cM r^ CM C_ cn cΛ θ ιn m ιn ι ιn ιn ι ^, ' ι — |i ι* — * "- in ¹ i" 1 1 ' i ii 'r co co c i in r c cM co cM cM r CM M r

O_OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO O_OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

HHHHH ri rH rH rH ιn r- ιn oo c '» co ιn cθ '» o ι~ co r~ vo n cι ιo cn H θ H H c «* '^ ιθ H θo o^ H r~ crι r~ ι ιn ι-~ o c c c cD o ιn r^ ιn r co ^, cD ^

O Λ rl » O N » ι o « r• H ^ n « ι ι^ o « ιιl N Mβ Mn « ιn o H ^ n o » ^ r• H ^ o β ι^ β β » B <^ d n « o o ιn N N ιo N ι<l Λ ιn * H ^• ^ ι o^ N Λ Φ d d m o σι Ol ^ ^ o Λ » r• N m o <Iι O "l^| d "f r• N ^ B o^ Φ Φ d d O « O ln lO H <» O ln ιO d » N o | ln (^l (1 0 ιn m co cM co cM _ r~ σ> o r- iD r- l O O Cn en cn oO cn H CM H H CO CO CM H H H O H CM CM rO CM CM i in in m vO VO CM H O σi H CO CΛ cD r- vo t- t- co r- oo r~ ιo r~ co

' in ιn ι^, ιι ι ι^, ι^, ιn ιn ιn ιn ιn ιn ιn ιn ιn ιr) in ιn ιn ιn ιn ιn ιn ιn ιr) ir) in ιn ιn ιn ιn ιn ι< ιn ιn -r o co vo m co cM r~ co o CM i^, ro o co [-. r-. cM co _O H co i n * B <H O d B IH n d l^,l » ιn » Φ » Φ ^ B N M N O n d (<) 0 <l^l « ro T "* CM vo co co ro cM θ CM θo σι ιn ro cD ro r~ o iN ιn cM in csι co r- "- ro t-. cM o co cM cn r— ro oo ι^, co r~ ιn cM CM θ ^ι ι^, i" θ o ιo ι ιn <n cD CM in cM CM σι σι σι CM ι CM r~ <n co oo vo ci in iinn ^ σi N O Λ m io N i ^ i in ^ ^ Λ f _> co ιn <n o oo cΛ ( CM cn H in oo cM ro oo H θo vo i' in cM ^, σι ι^, CM Co co cM θo ιn <n co r— co oo co co oo oo co

CM CM CO H CM CM CO CM H O CM " ιn ιn ιn co co ιn r^ ιn cD r~ ιi) iD co co c~ oo o H oo cn o H CM cθ H H σv H cn θ H H H CM θ cn H CM CM co o cn oo cn r- oo o co ιι ι^, ι ιⁱ ", "- "- ^{, ι} ι^{ι ,} ι^, ι ι ιι ιn ιn ιⁱ "- ιn ιn ι ι ιn ιn ι^, ι ι^, ιn ιn ι ιn ι tn ^, ι ιn ι ιn ιn '3^ι ι ι "- ^ι ι •a¹ co H oo cM r H θ H n ιJl "ι^| ιn d φ ιη o n o αι ιn ιn o N r- r- τ ιn ι ^ι r cM c co co co co co fo ro

r-- r~ r- r-- r~ r~ oo ∞ c_ cD θo oo o3 cn cΛ <n σ cn <n cn cn o o o o o o θ H H H H H H CM CM CM CM CM CM CM CM CM CM co ro co ro ro ro c r <o r co c c c o r ιo r o c r r r ι ι ι ιι ι ι ιι ι* ι^, ι ι ιι ι ι ι ιι ιι * ιι i 'i ι ι ιi ' < < ft < < < < < ft < < < ft < < < < ft < < < tt ft < < ft tt < ft < < < < ft ft tt tt < < < < < < tt ft < ft < ft < ft < < < < < J D D D D D D D D O O O O O O O Oi O- C-I O- X P- CO CO W CO W W W W OT OT W CO OT CO W OT Cu P₄ t_ P₄ C C_H &ι θj C- θj (_ c_ aι < < rt rt w w ω ω ω ω ω ω q- g; pc; ; pcios ι-5 w w ω i-i w w H HHH H H H H H H H>H < H H

> > rH eJ cn al ai ccl oS ou Pu X eS eJ c-l i-; ft ft < < ft ft > > Hi Hi -l Hl Hq Hq Hl H3 αι Ciι Ci4 l_ι l_ι ⁽-4 C-ι W W W CΛ O OT a X a X X X O O O θ υ υ EH H EH EH EH EH EH EH EH EH EH EH EH

H CM H CM H CM H CM H CM uo mυ ooo a aozυ f υoumoυoυzo f o H U Q Q ft m o Q < m o m o a a u m o rt ωo Q Q ω ω ω M ii o ouuuuzυuoυυoz u υ o u o o υ o υ u z u u z z υ υ o oOT zooo u ooo z u o υ u d N ι^,l » ιn r^• oι o N ⁽ » ιn B 5l O d N ι^,l 'f ln Φ ^ B ⁽I> O d N n 1^, ln Φ ^ B lIl O d N Pl * ιΛ Φ ^ B m o l ( v m Φ ^^■ ffl ιJl O d N r^ ιrι ιn ιn ιn ιn ιn ιn ιn u^ Φ φ ^ ^ ^ ^ ^ ^ ^ ^ ^ o (D oo ^D co ^D CO o co ω ^ι o σ m cfl (Λ σ lIl (Jl ^>l o o o o o o o o o o H H d

CM CM CM Cl CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C CM CM CM CM CM CM CM CM W CM CM CM CM C CM

00 rH V© aaεε εoaεooεεoaoaoao a a a a a ε a ∑ s s ε o o o o o o o o o o o 2 o S o 2 o 2 o2 o O Oi ξ

© ooooaoaooεoaoaεoεoo fO oi r oi o o o o o o o ft < ft ft < < ft < < < < ft ft ft tt < < ft rt < < ft < < < < ft ft ft ft rt rt £ rt rt rt < ft ft ft ft

Table 4

ATOM 314 CH2 TRP A 44 32.378 48.629 46.565 1.00 29.97 C

ATOM 315 N ILε A 45 34.552 52.693 48.264 1.00 31.20 N

ATOM 316 CA ILE A 45 33.268 53.236 47.850 1.00 32.95 C

ATOM 317 C ILE A 45 33.283 54.722 47.516 1.00 34.02 C

ATOM 318 o ILE A 45 32.658 55.144 46.543 1.00 33.17 o

ATOM 319 CB ILE A 45 32.178 52.922 48.903 1.00 35.47 C

ATOM 320 CGI ILE A 45 30.810 52.896 48.221 1.00 37.51 C

ATOM 321 CG2 ILE A 45 32.220 53.935 50.052 1.00 34.79 C

ATOM 322 CDl ILE A 45 29.720 52.293 49.086 1.00 39.88 C

ATOM 323 N SER A 46 34.022 55.509 48.293 1.00 34.50 N

ATOM 324 CA sεR A 46 34.108 56.945 48.062 1.00 34.72 C

ATOM 325 C sεR A 46 34.660 57.298 46.682 1.00 33.50 C

ATOM 326 o sεR A 46 34.049 58.059 45.931 1.00 35.31 o

ATOM 327 CB sεR A 46 34.979 57.599 49.139 1.00 37.01 c

ATOM 328 OG SER A 46 35.062 59.004 48.952 1.00 36.66 o

ATOM 329 N GLU A 47 35.817 56.752 46.342 1.00 32.45 N

ATOM 330 CA GLU A 47 36.426 57.052 45.051 1.00 30.79 c

ATOM 331 C GLU A 47 35.655 56.407 43.898 1.00 28.80 C

ATOM 332 o GLU A 47 35.560 56.967 42.815 1.00 28.45 o

ATOM 333 CB GLU A 47 37.890 56.586 45.047 1.00 32.29 C

ATOM 334 CG GLU A 47 38.739 57.103 43.885 1.00 33.02 C

ATOM 335 CD GLU A 47 38.694 58.623 43.750 1.00 35.38 C

ATOM 336 OEl GLU A 47 38.484 59.322 44.765 1.00 34.56 o

ATOM 337 OE2 GLU A 47 38.880 59.121 42.622 1.00 37.44 o

ATOM 338 N MET A 48 35.102 55.224 44.125 1.00 28.98 N

ATOM 339 CA MET A 48 34.347 54.563 43.067 1.00 29.38 C

ATOM 340 C MET A 48 33.124 55.371 42.661 1.00 26.16 C

ATOM 341 o MET A 48 32.835 55.548 41.474 1.00 25.57 o

ATOM 342 CB MET A 48 33.929 53.163 43.510 1.00 30.17 c

ATOM 343 CG MET A 48 34.984 52.140 43.181 1.00 35.54 c

ATOM 344 SD MET A 48 35.418 52.268 41.419 1.00 41.72 S

ATOM 345 cε MET A 48 34.088 51.459 40.712 1.00 37.21 c

ATOM 346 N VAL A 49 32.419 55.877 43.658 1.00 24.72 N

ATOM 347 CA VAL A 49 31.230 56.664 43.415 1.00 26.13 C

ATOM 348 C VAL A 49 31.571 57.936 42.627 1.00 26.91 C

ATOM 349 o VAL A 49 30.843 58.328 41.720 1.00 26.96 o

ATOM 350 CB VAL A 49 30.536 56.929 44.775 1.00 27.95 C

ATOM 351 CGI VAL A 49 30.127 58.356 44.919 1.00 31.34 C

ATOM 352 CG2 VAL A 49 29.345 55.986 44.912 1.00 26.79 c

ATOM 353 N VAL A 50 32.711 58.547 42.940 1.00 28.46 N

ATOM 354 CA VAL A 50 33.167 59.755 42.246 1.00 26.04 c

ATOM 355 C VAL A 50 33.530 59.456 40.795 1.00 24.79 c

ATOM 356 o VAL A 50 33.280 60.268 39.888 1.00 24.49 o

ATOM 357 CB VAL A 50 34.434 60.343 42.927 1.00 28.79 C

ATOM 358 CGI VAL A 50 35.064 61.428 42.034 1.00 31.79 c

ATOM 359 CG2 VAL A 50 34.076 60.916 44.283 1.00 30.83 c

ATOM 360 N GLN A 51 34.149 58.299 40.575 1.00 21.97 N

ATOM 361 CA GLN A 51 34.556 57.921 39.230 1.00 20.73 C

ATOM 362 C GLN A 51 33.372 57.469 38.376 1.00 20.16 C

ATOM 363 o GLN A 51 33.330 57.730 37.169 1.00 18.64 o

ATOM 364 CB GLN A 51 35.624 56.820 39.281 1.00 23.46 C

ATOM 365 CG GLN A 51 36.954 57.225 39.943 1.00 25.10 C

ATOM 366 CD GLN A 51 37.537 58.540 39.407 1.00 26.66 C

ATOM 367 OEl GLN A 51 37.426 58.857 38.220 1.00 26.21 o

ATOM 368 NE2 GLN A 51 38.175 59.302 40.291 1.00 27.46 N

ATOM 369 N LEU A 52 32.413 56.779 38.988 1.00 19.42 N

ATOM 370 CA LEU A 52 31.234 56.348 38.233 1.00 20.76 C

ATOM 371 C LEU A 52 30.499 57.613 37.797 1.00 22.46 C

ATOM 372 o LEU A 52 29.989 57.688 36.684 1.00 25.99 o

ATOM 373 CB LEU A 52 30.316 55.470 39.098 1.00 14.75 C

ATOM 374 CG LEU A 52 30.913 54.124 39.544 1.00 16.56 C TOM 375 CDl LEU A 52 30.008 53.506 40.584 1.00 13.24 C

ATOM 376 CD2 LEU A 52 31.094 53.187 38.341 1.00 11.80 C z υ u o o o z u u o uo oo z oo o uo z ooo u υυυ z υu o uo u z u υ o ou o o z o u oυ υ υ o z υ υ o υ uo oz uoo rf r- ro •St f

O © β

CΛ

P

H m vo 11 o r- O CO CO OO lD CO OO lD in CM OO OO ' ' OO I' in cO CD o r- i" co H H H co r~ ιn cM H co r~ co r~ co ιn cD cn oo cn co n m r- ro o cO i- vD H Oo r i 00 00 H CM vo r- co ιn ro oo cΛ H H r-- iD co cn o ' Cθ cn ro i' cn ιn cn r^ o cn in r^ o cD io ι cn ιo co co co r~ oo ro ro H -θ H n o i r- c O O H CM i vD co ii oo σi o σi cM O H H H VD ro in r- cn oo r^ in cn o io in r^ r- ro i" co cD r- o o σ> <n o co ιι co ι~ r~ oo _> oo r~ r- co m r- cn r~ oo cn cM to ro ro o H m co m ro

CM CM CM CO CM fO CO CO ro rO CO I' l' l' CM CM CM CM CM rO CM CM CM CM CM CM CM H CM CO CO CM CM CO CO CO rO rO CO rO T ' co ro ro ro ro co o ro co i i' i ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

H co cM θ rM oo r~ θ H in cθ H i o ιn H i^, H c~ ^, <n co cM in ro cθ ι~ r- r- <M θ ιo o cn 'i' r- H i' i' r- r-- ro θ 'j' u σι i co'i m-ι co o in CM OO O O OD H CO lO t- H CO r- r- ιn "p Φ ιn m σ> B σι w o B r" r- m m ι~ B B θ d i^,i "i^, -) d "f Λ i (^,i Φ m N C) oi d ^'" Mfl Φ oo co cθ H θ r- " in co <n cM c_ co ( H CM iO H o <n cD i cM H i r~ r~ i w r- c» n _ -i ci) D _> o - c i o i r- n c in i^, H H <n c O C CD in r- M H > r— m H σι r- o cM H r~ ιn m H o

B α) Cft σι Mn ^ n Φ ιπ 9^| v ^ (^ (l d ι^ ^^ (n (^,l cι 1r ιO Φ ι^ϊ) (^ϊl f d O M ιfi M o σι ^ O d d (Λ B B ^ σι B t" Φ ^ o o 5l d ^ Φ ιo v ro io c co to ro co co co co co co co co co ro ro c co co co co co co co co ro co co co co ro co c co co ro cM CM co co co co cM CM C^ n ^ H ^ Φ O B m d o Λ d ι»ι Φ O B d ιn o o ιn Mn " ιIl o <l^| ιo Jl n o N B π ln 5l β ι ι«l Φ B 1^| O "» lM « Φ < d ιn oι ιn « ιn Φ d ^ r- r M ιn n ω d m ln ιn ln ^Jl m ^ ι<) H (^l B ln B ιn m ι«) co fl M ln ^ σl c^ι ra cι Φ ι«ι ι») l ιη l d r• M ι<l Φ c^ fll d ( "» ιn o Φ lC B l1 0 B d N » 0 <f O ^ « d (1 ιr B Φ "f ιn ffl 01 N r- Φ <Iι σi fJ » θ n d r- 51 d 9 M^l ιl' d » O d Φ in i»l 'r Φ n n ιn d (JI O ιn θl lJl N ffl

Ol lΛ O d O (^ι o O d (l ( d σl β ^. B Φ B O^ o^ Φ Φ ιn o ^l (ι n ι^,l r^,) ^ d d H N <^l ^^ o ol <ιι <Iι ^ Φ Φ Φ O d M ^l ^l N ^l (^,l N n n ι»ι ιn > Φ Φ Φ Φ Φ Φ Φ Φ >Λ ιo ι >n ιrι >n >r) ι ι ιn ι ι ιn >π Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ i m >n ιn ιπ m ιn Φ Φ Φ Φ Φ Φ Φ Φ ι^,l ιn o^,) d ι ι ι^ ιn ιn d ^ ιn '^^ ^ "^ Φ m n d ιIl ^rι ^ "^ t- Φ ^^,) Φ Φ (^ Φ Φ d ^l " (O N o r• 'f n (l d lll ^ » ι«ι ι»ι r■ d ^ ιn β ιn d Φ O Φ ιJ> ω m ιo m o B "r ^ w d ^ ιn o a Φ θ tf * σi "]^, N «ι «⁾ Φ r- ιr ιι^, θ fl in ιn ι» iⁱ) ι/ι σι a3 i o ffl θ B θ ifi (- P) "i^, Φ j o ι^ri Pi (D iD (\i ⁽Λ tΛ ⁽η ^ v d ιι^, d ^ ^ 'r ω » ιn r- v N H θi ^ N ^ ri H h in ϊ ω ^ n o fl 'i' n ιιι ιθ ιn ι ι^jι ι») oi ιi' » H o H o n H "i' «> ιr ^ ι» <ιι ιr d «⁾ i)j o> i£i r ai N aι aι ^ (ii H H θ o <Il O <ll <Λ m d N ^l N ι>l fl "f ln N ι o o ^M r^ σl ω ^ ^ ^ Φ ω B B B O O O O ι m « (M ιn ω ^ Φ B B B Φ ιn ιn "l^| ιO c^ ι n ^

C CM CO CM CM CM ro rO ro rO CO rO rO rO rO CO CO CO CO lO CM CM CM C^ CM CM C C CM CM CM CM CM CM CM CO CO CO rO CO CO CO rl CM C^

(¹^ ιη n (^ϊ) n ^*l ^ "J^, 1* ^ ^ ^ ^ ^ ι ιrnι ιιn ιιnΛ lιnO ιιnO ιlCnl ΦiD co cΦo vΦD cD co cD co ^r~ r^~" ^r-- ^c~ r~ rr~ rt-- ∞oo oo ccoo ωco co a3 BCD θo σcΛ σ<nl m<n flcrιι cn cn erι σ o o o o o o o θ H H H H in in in in in in in m m in in in m in in in in in iinn iinn iinn iinn iinn iinn iinn iinn iinn iinn iinn mm iinn iinn iinn iinn iinn imn iinn iinn iinn iinn iinn iinn iinn iinn iinn iinn iinn in in in in co io co cD co iD vo cD cD CD vo vo tt < ft < tt < < < < < < tt ft < < tt ft tt < tt tt < ft tt < < < < < < ft < < ft < < < ft tt < < < < < < < < tt tt <

⁽_ X ⁽r CH PM P- l^ fe O^j C C CH C- CM C_ X « θH θ, « D D O D D D D D θ- (_ (_ a; CH θ£! X C-ι Oι (-ι C-ι (_ a< C-ι aι D D D D D D D D D D D D D D D D C 0j C-ι CLι ω w w -i w ω w cg co Λ C w t ω ω cd w ω w ω w w w ω w w c-i x x x x x oi w ra n w n n w H H W H B iiJ iii w w w w iii W H B M oi oi oi oi

OT C CΛ W CΛ O rt rt rt rt rt rt rt rt W CΛ Λ W C ij Hl Hl Hl Hl Hl Hl Hl EH EH H EH EH EH EH »; < < < < ; ri: fg; j ι iH iH >u ι >H >H iH ^ >H iH Hi Hi Hi < < <ι: i): rt zoυo CΛ O d N (^,l ^ ln Φ ^ σl O ^^ι ιη v l Φ ^ o ^n o d N P1 V ln Φ ^ o ιJι o d ι ι»l 9 ιn Φ ^ ffi ιJl O N l 1r ιn r• cn ιIl O N n 1» l Φ ^ -) σl

^ ^ ffl B OO Λ m ιJl lI\ IIl <Il (JI IJl Ol O\ O O O O O O O O O O d d d d d d d d l N I N <M I N I^I N <M n ι»l n n ^ P) n n ( f1

00 rH ε ε ε a a a a a a a a a a a a a a a a a § 222 a a a a a a ε ε ε ε ε ε ε o o o o O O O o o o o o o o o o o o o o o o o o o o o o o o o o o o o o Oi £O O! O B 55 S o o o < S rt3 S <3 S rt3 S rt3 S rt3 S tt3 S <3 S <3 S f3t S tt3 S tt3 S f3t S <3 S <3 S f3t S <3 S rt3 S rt3 S <3 S ft3 S rt3 S rt3 rt rt rt rt S rt3 S rt3 S rt3 S rt3 S3 S3 S rt3 S rt3 rt rt rt S rt3 S rt3 S rt3 S rt3 S rt3 rt ft it

Table 4

ATOM 440 CB ASP A 61 28.397 64.715 26.694 1.00 51.20 C

ATOM 441 CG ASP A 61 28.573 65.800 25.644 1.00 56.47 C

ATOM 442 ODl ASP A 61 28.936 65.473 24.490 1.00 57.52 o

ATOM 443 OD2 ASP A 61 28.340 66.984 25.975 1.00 59.41 o

ATOM 444 N LYS A 62 27.299 61.893 25.136 1.00 43.35 N

ATOM 445 CA LYS A 62 27.368 61.130 23.897 1.00 42.66 C

ATOM 446 C LYS A 62 26.016 60.770 23.290 1.00 41.38 C

ATOM 447 o LYS A 62 25.952 60.226 22.190 1.00 39.37 o

ATOM 448 CB LYS A 62 28.203 59.869 24.122 1.00 43.03 C

ATOM 449 CG LYS A 62 29.589 60.198 24.636 1.00 44.02 C

ATOM 450 CD LYS A 62 30.413 58.960 24.877 1.00 47.44 C

ATOM 451 CE LYS A 62 31.784 59.335 25.411 1.00 47.28 C

ATOM 452 NZ LYS A 62 32.464 60.280 24.484 1.00 43.52 N

ATOM 453 N PHε A 63 24.938 61.091 23.998 1.00 41.93 N

ATOM 454 CA PHε A 63 23.595 60.796 23.507 1.00 43.46 C

ATOM 455 C PHε A 63 22.748 62.065 23.432 1.00 46.25 C

ATOM 456 o PH A 63 22.971 63.017 24.178 1.00 46.18 o

ATOM 457 CB PH A 63 22.900 59.768 24.417 1.00 40.85 C

ATOM 458 CG PHε A 63 23.607 58.442 24.492 1.00 38.31 C

ATOM 459 CDl PHε A 63 24.746 58.286 25.274 1.00 39.31 C

ATOM 460 CD2 PHε A 63 23.149 57.353 23.757 1.00 39.73 C

ATOM 461 CEl PHε A 63 25.420 57.065 25.325 1.00 38.30 C

ATOM 462 CE2 PH A 63 23.816 56.128 23.800 1.00 38.66 C

ATOM 463 CZ PHε A 63 24.954 55.987 24.586 1.00 38.08 C

ATOM 464 N SER A 64 21.776 62.074 22.526 1.00 48.63 N

ATOM 465 CA SER A 64 20.890 63.218 22.370 1.00 50.37 C

ATOM 466 C SER A 64 19.587 62.934 23.102 1.00 52.06 C

ATOM 467 o SER A 64 19.213 61.780 23.296 1.00 51.64 o

ATOM 468 CB SER A 64 20.621 63.479 20.893 1.00 49.86 C

ATOM 469 OG SER A 64 21.835 63.733 20.205 1.00 52.62 o TOM 470 N ASN A 65 18.890 63.992 23.493 1.00 54.25 N

ATOM 471 CA ASN A 65 17.649 63.856 24.239 1.00 57.80 C

ATOM 472 C ASN A 65 16.454 63.355 23.425 1.00 59.71 C

ATOM 473 0 ASN A 65 16.451 63.421 22.195 1.00 60.42 o

ATOM 474 CB ASN A 65 17.315 65.198 24.894 1.00 59.02 C

ATOM 475 CG ASN A 65 16.637 65.042 26.241 1.00 60.67 C

ATOM 476 ODl ASN A 65 16.614 65.975 27.050 1.00 61.56 o

ATOM 477 ND2 ASN A 65 16.074 63.865 26.490 1.00 61.15 N

ATOM 478 N ILE A 66 15.459 62.843 24.153 1.00 61.50 N

ATOM 479 CA ILε A 66 14.186 62.305 23.643 1.00 62.44 C

ATOM 480 C ILε A 66 13.529 61.546 24.806 1.00 63.95 C

ATOM 481 o ILε A 66 12.870 60.519 24.616 1.00 64.12 o

ATOM 482 CB ILε A 66 14.365 61.321 22.447 1.00 61.28 C

ATOM 483 CGI ILε A 66 15.643 60.496 22.623 1.00 61.28 C

ATOM 484 CG2 ILE A 66 14.337 62.085 21.132 1.00 61.26 C

ATOM 485 CDl I A 66 15.873 59.478 21.519 1.00 59.60 C

ATOM 486 N sεR A 67 13.718 62.085 26.009 1.00 65.07 N

ATOM 487 CA SER A 67 13.213 61.514 27.262 1.00 65.71 C

ATOM 488 C SER A 67 11.736 61.136 27.338 1.00 65.66 C

ATOM 489 o SER A 67 11.220 60.882 28.431 1.00 65.09 o

ATOM 490 CB SER A 67 13.534 62.467 28.420 1.00 66.10 C

ATOM 491 OG SER A 67 12.963 63.747 28.205 1.00 64.67 o

ATOM 492 N GLU A 68 11.058 61.086 26.196 1.00 65.62 N

ATOM 493 CA GLU A 68 9.641 60.736 26.182 1.00 65.03 C

ATOM 494 C GLU A 68 9.419 59.263 25.815 1.00 63.78 C

ATOM 495 o GLU A 68 8.519 58.935 25.040 1.00 63.37 o

ATOM 496 CB GLU A 68 8.898 61.640 25.197 1.00 65.93 C

ATOM 497 CG GLU A 68 7.406 61.729 25.450 1.00 67.61 C

ATOM 498 CD GLU A 68 6.706 62.641 24.464 1.00 68.82 C

ATOM 499 OEl GLU A 68 6.517 62.225 23.299 1.00 68.58 o

ATOM 500 oε2 GLU A 68 6.356 63.776 24.857 1.00 68.78 o

ATOM 501 N GLY A 69 10.242 58.380 26.376 1.00 62.73 N

ATOM 502 CA GLY A 69 10.112 56.960 26.089 1.00 60.38 C Table 4

ATOM 503 C GLY A 69 11.318 56.129 26.496 1.00 58.08 C

ATOM 504 o GLY A 69 11.721 55.220 25.766 1.00 57.97 o

ATOM 505 N LEU A 70 11.891 56.449 27.659 1.00 55.78 N

ATOM 506 CA LEU A 70 13.061 55.748 28.204 1.00 51.80 C

ATOM 507 C Lεu A 70 14.243 55.633 27.242 1.00 49.05 C

ATOM 508 o LEU A 70 14.664 54.529 26.895 1.00 47.57 o

ATOM 509 CB LEU A 70 12.670 54.344 28.669 1.00 53.32 C

ATOM 510 CG LEU A 70 11.781 54.192 29.902 1.00 54.23 C

ATOM 511 CDl LEU A 70 11.330 52.742 30.021 1.00 55.04 C

ATOM 512 CD2 LEU A 70 12.542 54.631 31.143 1.00 53.18 C

ATOM 513 N SER A 71 14.776 56.770 26.812 1.00 45.73 N

ATOM 514 CA sεR A 71 15.924 56.781 25.912 1.00 41.79 C

ATOM 515 C SER A 71 17.195 56.580 26.741 1.00 38.39 C

ATOM 516 o SER A 71 17.169 56.692 27.962 1.00 36.09 o

ATOM 517 CB SER A 71 16.004 58.122 25.182 1.00 40.37 C

ATOM 518 OG SER A 71 16.164 59.185 26.107 1.00 40.70 o

ATOM 519 N ASN A 72 18.307 56.286 26.078 1.00 36.35 N

ATOM 520 CA ASN A 72 19.559 56.102 26.794 1.00 34.21 c

ATOM 521 C ASN A 72 19.874 57.380 27.554 1.00 32.13 c

ATOM 522 o ASN A 72 20.222 57.343 28.734 1.00 32.02 o

ATOM 523 CB ASN A 72 20.699 55.750 25.823 1.00 33.32 c

ATOM 524 CG ASN A 72 20.574 54.334 25.271 1.00 34.31 C

ATOM 525 ODl ASN A 72 19.927 53.489 25.878 1.00 34.94 o

ATOM 526 ND2 ASN A 72 21.205 54.068 24.128 1.00 36.96 N

ATOM 527 N TYR A 73 19.723 58.511 26.880 1.00 32.21 N

ATOM 528 CA TYR A 73 19.986 59.810 27.490 1.00 33.90 c

ATOM 529 C TYR A 73 19.269 59.956 28.833 1.00 34.77 C

ATOM 530 0 TYR A 73 19.876 60.292 29.854 1.00 35.67 o

ATOM 531 CB TYR A 73 19.522 60.941 26.557 1.00 34.65 C

ATOM 532 CG TYR A 73 19.867 62.324 27.081 1.00 35.46 C

ATOM 533 CDl TYR A 73 21.042 62.965 26.695 1.00 36.50 c

ATOM 534 CD2 TYR A 73 19.057 62.951 28.024 1.00 36.48 c

ATOM 535 CEl TYR A 73 21.402 64.196 27.242 1.00 40.10 c

ATOM 536 CE2 TYR A 73 19.408 64.175 28.580 1.00 37.06 c

ATOM 537 CZ TYR A 73 20.578 64.793 28.189 1.00 40.24 c

ATOM 538 OH TYR A 73 20.931 65.999 28.757 1.00 44.57 o

ATOM 539 N SER A 74 17.967 59.702 28.820 1.00 34.84 N

ATOM 540 CA SER A 74 17.142 59.827 30.014 1.00 35.51 C TOM 541 C SER A 74 17.541 58.899 31.151 1.00 33.42 C

ATOM 542 o SER A 74 17.619 59.317 32.310 1.00 34.04 o

ATOM 543 CB SER A 74 15.674 59.599 29.642 1.00 38.11 C

ATOM 544 OG SER A 74 15.547 58.459 28.803 1.00 42.69 o

ATOM 545 N ILE A 75 17.785 57.637 30.825 1.00 31.51 N

ATOM 546 CA ILE A 75 18.167 56.660 31.833 1.00 28.28 C

ATOM 547 C ILE A 75 19.512 57.029 32.469 1.00 28.34 c

ATOM 548 o ILE A 75 19.673 56.975 33.688 1.00 28.58 o

ATOM 549 CB ILE A 75 18.243 55.254 31.203 1.00 28.45 c

ATOM 550 CGI ILE A 75 16.832 54.800 30.812 1.00 27.74 c

ATOM 551 CG2 ILE A 75 18.895 54.269 32.174 1.00 25.94 c

ATOM 552 CDl ILE A 75 16.796 53.502 30.039 1.00 26.89 c

ATOM 553 N ILE A 76 20.471 57.400 31.632 1.00 27.29 N

ATOM 554 CA iL A 76 21.788 57.787 32.095 1.00 27.88 c

ATOM 555 C ILE A 76 21.663 59.010 32.997 1.00 29.70 c

ATOM 556 o ILE A 76 22.229 59.046 34.100 1.00 27.15 o

ATOM 557 CB ILE A 76 22.694 58.113 30.904 1.00 26.65 c

ATOM 558 CGI ILE A 76 22.845 56.863 30.028 1.00 24.16 c

ATOM 559 CG2 ILE A 76 24.053 58.595 31.397 1.00 28.04 c

ATOM 560 CDl ILE A 76 23.625 57.094 28.747 1.00 21.67 c

ATOM 561 N ASP A 77 20.914 60.009 32.537 1.00 32.01 N

ATOM 562 CA ASP A 77 20.709 61.219 33.338 1.00 34.74 C

ATOM 563 C ASP A 77 20.169 60.786 34.701 1.00 33.99 C

ATOM 564 o ASP A 77 20.594 61.286 35.738 1.00 34.81 o

ATOM 565 CB ASP A 77 19.710 62.158 32.650 1.00 38.27 c oo o z υ υ o o o o υ z z υ o o υ u oo z oυ o υ o o z υoo υ oo z z u uo u u o u z u u o o υ u z υ υ ou o o o z υ υ o υ

4 r- ro

© © CΛ

H o ιn H io σι ιn oo c r-- cM H m α> ro cM σι cΛ o r~ ro rM i- o oo co ιn co ιn ιn <n co o cD vo H in co ιn ι m σι r~ o iD CD σι ιι oo r~ cM co σι ι cD o r~ co ιι oo oo J CM CM t^ cn co ro oo o oo ι cM r- ' θo ιn r~ co co r-- vD r~ r- MJl d ro <Λ ι^, o ιn H θo ιn oo co r- co <τι ro σι cn H CM co co co α⁾ θ-ι oo oo ιn co oo cM in r~ co oΛ in cM

PH O CO II Iⁱ r .. --1. H . . iO O H H Cl H H cn ιn cM c ι ιn i' in ι^, ' ro cM CM in co ιn cn ro to cM CM i^, - ιn co cM ro r H CM i' CM Cθ i' Cθ ro r~ o ι* ⁱ in T i¹ ro ro ro CcOo CcOO 'r¹ i' in in co ro co ro CM CM co co to co co co co co co co ro co co co ro to co co co ro ro co ro ro co co co co co i co -p co co co co co

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

CO CM 00 CO Φ CD CO CM H r* CΛ co cn m CM M CM co co co in T IO vo co co c T in co oo in co io oo cn co io r- oo io in i CD io co oo cn in co i oo cn o H cn oo r- r- O H CM ro H O CM O CM CO O CΛ H H CM CO -P O O ι m co r- in nrιonnnnM( nn ιnιη(»)i^,ιnr^,i(nflr>ιmιonn )cnι^y)<«i"i^,"i^,nnΛn'i^,v"»"i^|« H -p i O II ιι o ι^,l 1^, B O B lJl d d oι ( d ιO "l^| » lf) 0 ^ 0 "l' B N N ιn o O ( m o ln o r• B lIl N Φ n Φ ^ d Φ fl m Φ ll10ι ιn o ^ (O d ln o ιn N ιn iJi θ N n Φ d o> ^ Φ ιn ιn ^ o « "( i<i M^ Φ ιιι oi σi Φ oι o N d n B v ιn » N d in B Φ Φ » Φ o π ι^ι θ B in ii' » d i«ι θ d r" i^, ιιι n o N in ιn ol ι to ι»ι n »Ol ^ o nι«ι ^l N d ^^ 9 '^ O N tfl^ o pl O Φ « N (ι <Il lJι mo 1' ( ιno ^^■ ^ o o !M N ^ 9 Φ B ^f n d ι<l 9 ^ o n n <ι' (!> <!^ B B B ln ιn B Φ ιn tι■ 1^' m o d d l d N d N ι^,) 1^| N l^ ω ^ ^ B O o o β 5ι ^ (M ( n n (1 ι^,) •» N lM d N φ Φ Φ in m in in ^ in ifl in m in m iii in in in iπ in i Φ Φ Φ Φ Φ Φ in ifl in in m i in t m in Φ i m m Φ Φ Φ Φ lΛ « (0 φ (^,)

(I^ N

H

r^ r^ r^ CO B CO O CD CO B B -t ^ m iTl h Cn <n CTl O O O O O O O H H H H H H H H lM CM CM CM CM CM CM CM CO CO CO CO CO rO rO lⁱ lⁱ lⁱ 1 "- 1ⁱ 1 1' in in m in in r~ r- r- r- r- r- r- r r- r- r^ r^» r~ r^» r~ r- r^» t^ i— M r- 9 CO m B B B CO O Φ CO > B Φ Ofl B m B IB Φ <D ω B O B Φ B CO B O B O B B m B < tt tt tt tt < < ft tt ft < < < < tt < tt < < < tt tt < < < tt < ft < < ft tt < < < < < < ft < < < < tt tt tt < < tt tt ft ft tt < < < ri HH HH ^ z z z z z z z z ω ω ω ω tii ω ω ω HH iH HH aι m _ι _< Pj -ι [_ ø- c θH θH CLι θπ ω w w H H ^H r^{H H} H H >^{H H} C2j ω ι_ι ω ω i-i c_ ω rt rt rt rt rt rt CΛ CΛ W CO CΛ CΛ CΛ CO Hl Hl Hl Hl Hl Hl μi Hl rt rt rt CΛ W CΛ CΛ CΛ CΛ CΛ W W W W CΛ CΛ

«( f); fi; μi >H ^ >H ^ Hl _lH >H >H Hl >H i >J ^ > j i > > > > > > tt tt ft ft < tt < rH i ri rH ri ri ri i > > > > > > tt ft ft tt tt tt ft < ft ft ft <

H CM H CM H

CoD ^Qoo^Qzυ <υoυ m OυQυυW Nzz <υυoυOυQoQυz fυtυ m o o et o a a rt m o o a ft m o o m o a a o o u υ z u o o oυo z z u u o oυ oo z u u o u o u Z O U o υ o o g o m υ ^φ ^" ιJ^ od ⁽ι ι^,) "f ιfl Φ r~ ^Il ιIι o d t^l ⁽M ^f ιn ^ mm o d (^ι n >τ ι Φ ^ B ⁽Il O d cι n 1l' ιr)Φ ^ (ll O Nn ^ ι Φ r• lJ O ^l ( « κ) ^' Φ Φ ^ ^ ^ r^■ r- r- ^ r^• β B o B C ffl<n ιIl Olmσl<ΛιIl O>ιIι ιIlO O o o ooo o o o d d d d d dN W NN (! N^l NN ιnιrιιrιιntn>n ιnιnιriιrιιn ιnicι ιnι ιπιii ιnι'i ιn>rι >n> ι uι> ιnιn>n> ιnιoιn ιnΦΦΦ ΦΦ ΦΦΦΦΦΦΦΦΦΦΦΦΦΦΦΦΦΦΦΦΦΦΦΦ oo εosaaaεaoaεεa εε εa aooaoaaooaaaoa oaε

© EHoEHoHo EHoEHoHoH ooo oo oaoaoaooaε EHoHoEHoEH ooaoεao o ft rϊ. ft ft ft f rt tt rt ft rϊ, ft ft tt < < < < ft S tt3 S3 S<3 Stt3 S3 S<3 S<3 S3 Sft3 Sft3

ooozoooooυυzuuoυυυzυυooυυoozoooowzoooυoυzυooυooozzυυoυoooozυooυ rt t-. ro •JS

O © CΛ hi cΛ in co co H co o o H H θ CM in H in r~ cn co vD cn cD co co H co co <n o ι~ co ιn ιo ιn r~ ro ιn cM CΛ cn ιo cn o oo ro cM ro o ιn ιn o _ ιn. o_ CM H in CO H r- o co in ι- 1- 'r 'r cM O co in o in cM CM '^ o i r in cM CD Oo cM O M ro cn co H OO O i i cD r^ i' C CM 'r ⁱ »ccoo cCNM rno«i" vlβo CJ H r ∞ H W t^ c c^ σi r oo H in «-p o0«lf)dM"K)d

_'ι^ιn ιnιn^BB Φ mNln«NNHfflN<ι^|^ι»l1^ιmBω^c\lMN^ N(^,)<M n«_^^n"l^ιmlnvιnΦ ^ΦO) BBHNOdCllΛ<Il o (^,)f^nι»_ln( (^,^f^^ nι^,l( "^"^^vvflfl'ιnιr)l ιnι lnιommΦΦΦΦ^Φ Φ ΦΦ ΦΦ ΦΦΦ f~^ ^φ φ ^■ ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

cn cΛ co o vo H io co cM io co co co cM CΛ co o r- ccnn oo cσni oo cσni mm ccMM rr—— CCMM OO HH r— i" θ Hl c σni ι — rι o ooo ι Unl o _ι o _> cM c _o• r r-- c roi c ι,M c 1*o1 c roj r r—~ o wo o _ o o m o H vo vo r- cn H co o "tf ιn r- oo ιn r~ ιn cM ^, H H θ co cM co ιn ιn ιn H θ co σι io oo cn co oo H cn cD ( i iπn oo v> dH icoy vwo rHi θυ ci'oi icM αθoj cnn Hi iuni vιo proi ciM θυ oωo π ιo rr~ «-' cϋni Hri c Wnl cCM CIM v—o' l T H T T CTi r— O H O cn o ro o cM co cM CΛ CM OO co ro iO LO O cn in ro ro co H r~ o ιn oo cM r~ r~ o co t~ H in co c~ ιn cM co o cM θ ' in <n r~ i' H ro H H CM H m vo r- oo co in in r- ιo co r~ oθ 'r ιn co c-- αj <n o cD io co ι^ ιn ιn H H CM H CM θ H H CM θ o σ^ H H CM co o cn oo r~ ιo co ι ιn vD co cM CM CM CM in co ιo ιo ιn 'r ι ι ι^, ι * '^ '^ ^, ι 'r 'r ι« ι^, ι ιι ιn ιn ιn ιn ι ιn ι ιn ιn ιn ιn ιn ιn ιn ιn ιn ^{, ,} ι ι ιn ιn ιn ιn ιn ι ιn ι ιn ιn ι ιn ιn ιn β « ιft n d ι^,) n o Φ β β ι^ι κι * l" Λ d Λ » ιl) » ι o o N o ιIι » β β o ιιl ^ ιπ » ι » ι^,l Φ <^| ι^,) n n <ι o » ^ » * » β * N ι») O Ol ιn ) O Λ o n « Jl "» Φ Φ Φ O d lIl ιn ιn d m oι ^^ σι <J\^l '*ι (O ι»l f^ <f 1n ι»l 'f ι)l O 'l^| o^ >lι φ Φ (^ι fl ιn ιf ln Φ "f l^,) Φ B ιn ol Φ N 9 m N n o O d m ^ « » ln N N l^,l d ιΛ l)ι B O ^ι <J ^• '» B ln « Φ N ιn d ιn n d lrι Φ r■ v Φ 9 Φ o ιO ln ol m ιIl n « ln ^ι t^ι <r l M c 'r c θ C o cn oo r~ ιn co o H C CM CM ro H r i' to cθ 'r ιn vo co co cM H H H o m o o H H σ^ n c_ C o ι 'r ι 'r ιn ιn cD 'r '^ r c ι ιn ι r~ cM H θ cn o φ φ φ φ ιn Φ ιπ ιfl ιn ιrι ιn Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ in Φ Φ Φ Φ tθ ι ιil Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ ιl Φ -r

« « o m ^■ B B O oι B N n ^ » N Oι o oι B » ^ H ^ ιn β oι r• w oι d oι ι ι" ιn o B n d n n « ιι ιn ιι⁾ » ιΛ β ^ d H lβ ιn n N n l d ι. ιIι n B ι ^ ι m B « n β o ιn Φ » o ιo « ιn ι^,ι oι β « w Φ ol ιβ » B O O B N O O ι o B ^• Φ o « ιn ^^■ ffl d ('l ffl (^ Φ β * (^ Φ ιo β » n ιn fl' ω 1» o r• (>l ^■ o ^l Φ <l' r^ n Λ ιn (l M O ω ^ ι»1 v d w ^ ιfl Ol ω Λ d <n r- l 0 lfl (M H (Il O^ o o cι ιn τ O N ^ d d ri O ιn ι^l ^ ^ ιrι 9 ln * r' ιIl < o ιIl ^ ^• β lO ιl) <^ ι^,) » l£ι lι) ^ B ln ι/l lIl O O N ιJl O d d d l N l^l N lIl Ol Ol lIl r■ ^l) ιfl ln !ιl o o

C CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CO CM CM CM CM CM CM CM CM W CM CM CM CM CM CM CNI CM CM CO CO CO CO CSl rO CO rO r^

ιn _θ -θ vo o o ^ vo vo *o o r^ r^ r^ r^ ι^ r^ r^ co co oD ∞ ro ft ft < tt < ft < ft < < < < < ft ft < < < < < < < < < < tt < < < < < < < ft ft tt < ft < < ft fC tt tt ft ft ft ft < < < < ft <

D _> D ^ ^ ►J πl tJ W CΛ W W M W CΛ CΛ W D D D D D D D D D Z Z Z Z Z C OT CΛ CΛ

( w<c It< JωJω₍ωH HωI JωwIJ Hω! Jw>rt>rt uo oøoooooooooo> . . . rt rt rt " >H - H >H H H >H H Hl Hl Hq H Hq HP t-l Hl Hl > rt> > > Hl Hl Hl Hl Hl Hl Hl H H > > S> l H3 0 0 _I O O O _I rt rt rt rt rt o o u o υ o z rtoooomoυoozo ttoo mooooαωooω ft mo < cn o H csj ro i in co r- co σi o i r ι^, ιn ω t~ oo σ θ H C ro ι^, ιn co t^ oo c o H M c '^ ιn vD c~ CD ^ θ H r ι ιn vD r~ c» c^ θ H C r i' i co r-- oo c*ι θ H CM CO fO ro ro co co ro ro co ro ii '^. ^r ^-sj. , ιJ■ q, ^ fl ^ ιn ιn ιn Λ Λ ln ln Λ m ιΛ Φ Φ Φ Φ Φ ^ ^ ^ ^ ^ _) lB oo oo o o m m B o m -Λ VO VO VO IO IO CO IO CO VD VD CO IO VO — > ι CoO CO CD CD CD CD IO CO IO IO VO CO CO VO CD IO CO VO CD CO CO CO IO CO CO CO CO CO CO CD CO CD CD CO CO VO CO CD CD CD CD VO CO IO CO CO CO CO VD

00 rH oaoaoaoaoεoεoaoaooaoaaoaooaao aooaaoaoaooaεoεooεε εoεoεεoεaaεεεεa aoooaoaaoaoaoaoaooaaooaao εoεoaoaooaoaaoaoaoaoao o t3t St3t Stt3 Stt3 Stt3 St3t Stt3 St3t Sf3t Sft3 Stt3 Sf3t St3t S t3t St3t St3t St3t Sft3 St3t St3t Sft3 St3t Sft3 Sft3 it

TabJe4

ATOM 692 CG ASN A 93 26.317 60.936 56.107 1.00 71.63 c

ATOM 693 ODl ASN A 93 26.000 61.420 57.193 1.00 71.75 o

ATOM 694 ND2 ASN A 93 25.510 60.956 55.052 1.00 71.69 N

ATOM 695 N SER A 94 31.239 61.250 56.366 1.00 71.08 N

ATOM 696 CA SER A 94 32.582 60.680 56.420 1.00 72.71 C

ATOM 697 C SER A 94 33.074 60.398 57.841 1.00 72.70 C

ATOM 698 o SER A 94 32.984 61.248 58.730 1.00 72.27 o

ATOM 699 CB SER A 94 33.568 61.608 55.703 1.00 73.81 c

ATOM 700 OG SER A 94 33.476 62.940 56.181 1.00 75.51 o

ATOM 701 N SER A 95 33.599 59.189 58.031 1.00 72.69 N

ATOM 702 CA SER A 95 34.111 58.721 59.316 1.00 72.24 C

ATOM 703 C SER A 95 34.363 57.224 59.161 1.00 72.10 C

ATOM 704 o SER A 95 33.463 56.484 58.757 1.00 72.07 o

ATOM 705 CB SER A 95 33.078 58.963 60.421 1.00 72.42 C

ATOM 706 OG SER A 95 31.836 58.353 60.102 1.00 71.47 o

ATOM 707 N LYS A 96 35.581 56.781 59.473 1.00 71.80 N

ATOM 708 CA LYS A 96 35.948 55.369 59.334 1.00 70.97 C

ATOM 709 C LYS A 96 35.941 55.055 57.840 1.00 70.26 C

ATOM 710 o LYS A 96 36.373 53.990 57.404 1.00 69.79 o

ATOM 711 CB LYS A 96 34.929 54.470 60.043 1.00 71.97 C

ATOM 712 CG LYS A 96 34.719 54.773 61.518 1.00 72.65 C

ATOM 713 CD LYS A 96 33.535 53.988 62.067 1.00 72.31 C

ATOM 714 CE LYS A 96 33.365 54.197 63.563 1.00 72.18 C

ATOM 715 NZ LYS A 96 34.501 53.627 64.341 1.00 72.30 N

ATOM 716 N ASP A 97 35.435 56.015 57.073 1.00 70.01 N

ATOM 717 CA ASP A 97 35.321 55.930 55.623 1.00 69.44 C

ATOM 718 C ASP A 97 36.425 56.795 55.011 1.00 68.15 c

ATOM 719 o ASP A 97 36.615 57.937 55.427 1.00 67.24 o

ATOM 720 CB ASP A 97 33.937 56.449 55.215 1.00 70.94 c

ATOM 721 CG ASP A 97 33.650 56.265 53.745 1.00 72.18 c

ATOM 722 ODl ASP A 97 34.271 56.973 52.923 1.00 73.65 o

ATOM 723 OD2 ASP A 97 32.800 55.408 53.415 1.00 72.87 o

ATOM 724 N LEU A 98 37.157 56.256 54.038 1.00 67.60 N

ATOM 725 CA LEU A 98 38.240 57.017 53.415 1.00 68.68 C

ATOM 726 C LEU A 98 37.741 58.216 52.616 1.00 69.78 c

ATOM 727 o LEU A 98 38.022 58.334 51.423 1.00 69.16 o

ATOM 728 CB LEU A 98 39.096 56.121 52.507 1.00 67.38 c

ATOM 729 CG LEU A 98 40.061 55.113 53.148 1.00 67.16 c

ATOM 730 CDl LEU A 98 41.063 54.637 52.097 1.00 65.06 c

ATOM 731 CD2 LEU A 98 40.807 55.758 54.311 1.00 66.45 c

ATOM 732 N LYS A 99 37.010 59.106 53.284 1.00 71.95 N

ATOM 733 CA LYS A 99 36.470 60.300 52.641 1.00 73.06 c

ATOM 734 C LYS A 99 37.514 60.934 51.733 1.00 73.45 c

ATOM 735 o LYS A 99 38.408 61.647 52.188 1.00 74.34 o

ATOM 736 CB LYS A 99 36.013 61.324 53.689 1.00 73.26 C

ATOM 737 CG LYS A 99 37.123 61.846 54.598 1.00 76.26 c

ATOM 738 CD LYS A 99 36.663 63.051 55.420 1.00 78.03 c

ATOM 739 CE LYS A 99 37.794 63.598 56.295 1.00 78.42 c

ATOM 740 NZ LYS A 99 37.377 64.795 57.091 1.00 77.23 N

ATOM 741 N LYS A 100 37.397 60.657 50.440 1.00 74.11 N

ATOM 742 CA LYS A 100 38.320 61.197 49.453 1.00 73.86 C

ATOM 743 C LYS A 100 39.731 60.728 49.762 1.00 73.67 C

ATOM 744 o LYS A 100 39.917 59.744 50.475 1.00 73.41 o

ATOM 745 CB LYS A 100 38.255 62.727 49.453 1.00 74.51 C

ATOM 746 CG LYS A 100 38.514 63.373 48.097 1.00 75.16 C

ATOM 747 CD LYS A 100 38.165 64.857 48.144 1.00 76.21 c

ATOM 748 CE LYS A 100 38.280 65.517 46.776 1.00 75.62 c

ATOM 749 NZ LYS A 100 37.939 66.967 46.843 1.00 74.24 N

ATOM 750 N SER A 101 40.705 61.454 49.222 1.00 73.99 N

ATOM 751 CA SER A 101 42.134 61.174 49.366 1.00 74.29 c

ATOM 752 C SER A 101 42.577 60.588 48.037 1.00 75.40 c

ATOM 753 o SER A 101 42.055 59.561 47.595 1.00 75.14 o

ATOM 754 CB SER A 101 42.424 60.165 50.478 1.00 73.98 c Table 4

ATOM 755 OG sεR A 101 42.249 58.840 50.009 1.00 70.78 O

ATOM 756 N PHε A 102 43.532 61.255 47.398 1.00 76.34 N

ATOM 757 CA PHε A 102 44.047 60.822 46.108 1.00 76.69 C

ATOM 758 C PHε A 102 43.071 61.231 45.006 1.00 76.76 C

ATOM 759 o PHE A 102 43.028 62.394 44.595 1.00 76.40 O

ATOM 760 CB PHE A 102 44.237 59.299 46.092 1.00 75.92 c

ATOM 761 CG PHE A 102 45.223 58.823 45.069 1.00 77.00 c

ATOM 762 CDl PHE A 102 46.583 59.073 45.231 1.00 77.34 c

ATOM 763 CD2 PHε A 102 44.799 58.129 43.945 1.00 76.96 c

ATOM 764 CEl PHε A 102 47.507 58.638 44.289 1.00 77.66 c

ATOM 765 CE2 PHε A 102 45.714 57.688 42.994 1.00 78.03 c

ATOM 766 CZ PHε A 102 47.073 57.944 43.167 1.00 78.07 c

ATOM 767 N LYS A 103 42.278 60.265 44.555 1.00 76.89 N

ATOM 768 CA LYS A 103 41.300 60.467 43.489 1.00 75.84 C

ATOM 769 C LYS A 103 42.016 60.600 42.151 1.00 74.97 C

ATOM 770 o LYS A 103 42.033 61.670 41.538 1.00 75.72 o

ATOM 771 CB LYS A 103 40.434 61.706 43.754 1.00 76.14 c

ATOM 772 CG LYS A 103 39.321 61.908 42.727 1.00 75.38 c

ATOM 773 CD LYS A 103 38.326 62.977 43.159 1.00 75.24 c

ATOM 774 cε LYS A 103 37.647 62.607 44.470 00 76.66 c

ATOM 775 NZ LYS A 103 36.670 63.644 44.905 00 77.05 N

ATOM 776 N SER A 104 42.621 59.496 41.720 00 73.25 N

ATOM 777 CA SER A 104 43.343 59.435 40.457 00 70.83 C

ATOM 778 c SER A 104 43.823 58.012 40.156 00 68.77 C

ATOM 779 o SER A 104 44.997 57.790 39.849 00 67.79 o

ATOM 780 CB SER A 104 44.536 60.396 40.478 00 71.12 c

ATOM 781 OG SER A 104 45.419 60.096 41.542 00 72.02 o

ATOM 782 N PRO A 105 42.918 57.023 40.255 00 66.86 N

ATOM 783 CA PRO A 105 43.317 55.641 39.971 1.00 64.75 C

ATOM 784 C PRO A 105 43.604 55.486 38.481 1.00 61.83 C

ATOM 785 0 PRO A 105 43.587 56.464 37.738 1.00 60.17 O

ATOM 786 CB PRO A 105 42.104 54.830 40.429 1.00 64.56 C

ATOM 787 CG PRO A 105 40.969 55.755 40.161 1.00 65.66 c

ATOM 788 CD PRO A 105 41.499 57.085 40.652 1.00 66.17 c

ATOM 789 N GLU A 106 43.864 54.261 38.045 1.00 60.87 N

ATOM 790 CA GLU A 106 44.160 54.022 36.640 1.00 59.84 C

ATOM 791 C GLU A 106 42.910 53.757 35.812 1.00 57.01 c

ATOM 792 o GLU A 106 42.089 52.900 36.151 1.00 55.55 o

ATOM 793 CB GLU A 106 45.109 52.838 36.477 1.00 62.12 c

ATOM 794 CG GLU A 106 45.608 52.680 35.053 1.00 64.12 C

ATOM 795 CD GLU A 106 45.997 51.260 34.728 1.00 64.48 c

ATOM 796 OEl GLU A 106 46.598 51.047 33.656 1.00 65.35 o

ATOM 797 OE2 GLU A 106 45.694 50.358 35.539 1.00 64.07 o

ATOM 798 N PRO A 107 42.765 54.486 34.700 1.00 54.46 N

ATOM 799 CA PRO A 107 41.633 54.374 33.781 1.00 53.06 C

ATOM 800 C PRO A 107 41.696 53.166 32.851 1.00 50.35 C

ATOM 801 o PRO A 107 42.691 52.962 32.162 1.00 49.73 O

ATOM 802 CB PRO A 107 41.702 55.684 33.005 1.00 55.58 c

ATOM 803 CG PRO A 107 43.183 55.913 32.905 1.00 54.79 c

ATOM 804 CD PRO A 107 43.654 55.595 34.303 1.00 54.48 c

ATOM 805 N ARG A 108 40.640 52.359 32.844 1.00 47.27 N

ATOM 806 CA ARG A 108 40.589 51.216 31.945 1.00 45.13 C

ATOM 807 C ARG A 108 39.271 51.171 31.180 1.00 42.72 C

ATOM 808 o ARG A 108 38.344 51.927 31.469 1.00 41.21 O

ATOM 809 CB ARG A 108 40.839 49.895 32.688 1.00 46.99 C

ATOM 810 CG ARG A 108 40.379 49.829 34.119 1.00 47.99 C

ATOM 811 CD ARG A 108 40.904 48.555 34.807 1.00 49.01 C

ATOM 812 Nε ARG A 108 40.328 47.316 34.274 1.00 48.82 N

ATOM 813 CZ ARG A 108 40.335 46.146 34.918 1.00 49.68 C

ATOM 814 NHl ARG A 108 40.887 46.047 36.121 1.00 47.24 N

ATOM 815 NH2 ARG A 108 39.775 45.074 34.370 1.00 47.63 N

ATOM 816 N LEU A 109 39.196 50.289 30.192 1.00 40.92 N

ATOM 817 CA LEU A 109 38.001 50.174 29.375 1.00 38.05 C ooυ oo υ z o υ oυ υ o o o o o z ou o u o υ z υ u o u u o z u o o u υυ o o z o o o ooo o o z ooooooυυυυ z oυ rt r- Si ro "5J f

O

CΛ s ε H? r- co H CM co cM in in r- H O o i' O CM ro m ' co H cn co oo in in r- cn r- r^» ro cn oo ι^, o σι cM CM co oo o oo ιθ ι^ι ' r~ m i' CM CM CO CO CD T CO CO CM CO H CO CM CM CM VD r-- σι <n ro co r- ro co H <n o co o co m cD r~ co m ιo cn m ιn o oo — co ro o ^~ vo^"i 00 CM H CΛ r~- ιn cn o r~ ' H cn o cD o-) co r~ i' co in r- r~ i^, <n oo J

PH co co oo oo oo oo c H H cn o OT θ <n σι oo cΛ oo r- ι^ι ro r- r~ r~ ι^, ιn r~ r^ ιn i' ^| cn co o o r- ιn o cM "-f CΛ cn r~ ιn ro r~ cn cM r— co r~ co ιn cD θ θ o σi H θ co ιι _ι

CO CO rO rO rO CO CO CO CO CM ro rM CO CM CM CM CM CM CM CM CM CM CO CM CM CM CM CM CM CM CM CM CO CO CO CO l m m m CM CM CM CM rO CO CO I rO CM CM CM CM CM rO CO ro CM rO CO CM CM CM o o o o o o o o σ o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o

B ( 00 B co l tf) r- o m o m » 9 Φ

CM o co r- o m oo ιn H cn r- -ιi O O 00 -r- -ii o o o _> r-- cn cn oo c_ _> ro o c£ ) io oo o r- oo m cM m r- ' t~ <n m H io r~ ιn o H oo ι^, cM cn ιι ro o m o H H - cn co

H CO rO CO m O I' CM CM CM Cn co co cn cD θ cM H c_ co θ "- θ H in oo cn ιι ιn r~ cΛ in o cM r- H in co ιn o cD cn co cM CM cn oo r-- oo cn r~ ι cn <o r~ co ro cn cn cM CΛ iι O CΛ O H Cn m cM CM H H I m i" H co cn r- CM i^, CM θ ιn co H H in ro r-- r~ oo oo σ> <n i' iD CM H θ cn <-Λ CM ro oo ι ro cM ^, ro iD r- H r- H <n co cM θθ iθ "- iι ι cn r- O H O CM CΛ CO OO CΛ CO CO CΛ r- ρ-oocDcor~r-ιnιnι^,r-a)r-r~CDCor- m-r co CM CM ro vo co ii co ro CM r- oo co cΛ cn H H H co cM co co oo r-

"qⁱ T in in in in i¹ * ^{i i} 1i 1 -_r ι ι^, ι ι ιn ιn ur) ιn m n ιι ι^, -r' o » '» (n '* ιn d r• ^ ro ro

cn cΛ cn i-Λ n cn o o o o H CM CM CM CM CM CM CM ro co co ro ro ro co ro co io iπ Φ Φ Φ

OOOOOO HHo oHoHoHoHoHoH HHHHHHHHHHHHHHHHH "r i i iO ifl i i i iri i HHH ri ri rH rH rH rH ri rH ri ri ri ri rH rH rH ri ri rH ri rH ri rH rH rH rH rH rH rH rH rH ft tt < ft < tt < < < < < < < f ttt <ft << frtt < fttt fftt fftt << tttt << < << < <tt << < << << << < - < . < . tt , <., f.t, ., tt . ft . . ft . ft . tt . . < . tt . < . ft . < , < . . ft .

O . D D D D W W B W ω W M B W W M Λ Λ Oi li; KI CS OU O O O O O O O D D D D D D D D D D D D D D D D D D M W W W W W W W W W M W X X X B B B B B B B B B wWwWωWωωωW W

W W W B B B ωr-i ^j j ^j ^ J iJ ai ai Oi fe ai iij Oi Mij Pi Oi EH ti H ti EH H H Cπ Ci4 Pj pH C-ι C-i Cι< O O O O Λ CH Cij Cij C- CH _ ftι Ci' l_ι C, (-ι (-ι 0j

H CM . , CM H CM H CM m o Q Q ooυoυoaυwowoMz <υυo mυoooo tt o a tt m o Q ω ω ft Q bl U rt - U O Q W W N ft u o υo o υ z fot m a c zoooooυzou o o υ oo oυooυooozoooooυυυυozoo ffl Ol O d N m "|^l ln Φ ^ B lΛ O d ^ι ι^ '» ιn Φ ^ m o d c^ι n 't' lf) Φ ^ Λ O d N n ^, ιn ^ B m o d N n 9 ιn ^ B ιJl O d ^ι m "l^, ιn Φ r• (tl m o H H M cvι cM CM M M CM CM CM CM co ro ro c c c c r ιo '- i' i^, 'r "H" i '» "- i' i' in ιn ιn ιn ι ιn ιn ιn ιn ι co co co cD VD c^

CD CO CO 00 O- 03 00 03 00 03 00 00 00 0D 00 00 CX) CX) 0000 CX> 00 0000 03 03 CO CO CO CO C_ 00 CΩ 00 00 03 03 O0 00 00

00 rH

OaεO OaεO OaεO OεOaεOaOaO OaεOεOεO OεOεεOεO OaaOaOaO OaaO OaOaaOaOaOaOεOεOaO OaaO OaOaaOaOaOaOaOaOεOaOaOεOεO OεεOaO ε OεOaOaO OεaO OεOεOεεOεO o tt ft < ft < < ft ft ft < < ft < < < < tt tt ft < ft ft ft ft ft ft ft ft ft ft ft ft ft ft tt ft ft ft ft ft ft tt ft tt tt ft ft ft < ft tt ft < < < < < <

ooϋooooϋzυoooυυzυzzzouoooυozoooooυυυυυzoooυυozzϋooυoozozzzoooυo

co oo H CO H CM CM O i co cD r- CM CO CM r- oo co in ro o in iⁱ ro σi o i oo m ro oo cM co co vD O Co co cn co oo H CD r- cM cO H io o cn iⁱ cn H ' oo r^ co oo o m r- < ' c cg H iD H co ι vo ιι ιo oo cD oo cD "!r ιn m <n <n r-- r~ oo oo ιn H co o iD n ιι ιι ι ιι cM θ oo o oo ι t— oo oo o co ro cD ii c cM cn i ii iD O o m cΛ CM H cn CO H CM H CΛ H CO r-- cn H CM CM in σ> co r-- σι o o cn cn cn cn oo σ cD H θ H CM H H CM H H θ ro cM ro cM H r~ CM fo ro ιn H i ιn ro r~ H r- H CM CM CD t~ cn [~ 00 lO CM CM CM CM H CM H H CM co ro co co cO '- i' ' in in cM CM CM CM CM io cM co co co c co ro ro ro ro ro ro co ro co co cM co co ro co co ro ro co ro in in co co co ro ro ro ro ro ro ooooooooooooooooooooooooσoooooooooooooooooooooooooooooooooooooo oooooσooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H ιn ι») Φ o β l ιn m ιn fl' O B C>ι N ιn r^■ <f <^,l σl n H * d ιL m ^ φ N ιn rp r^■ ιJ^ v (^ι <! o^ o ^ o ^ ( lJl "^ι Φ o ι^,ι « o ^ <l^| CΛ ^ ιn d σl Mn "l^ 0 5l ln ιJl π o w N » » n ^^ O β O lO N ^ 9 < l') ι^r) Jl Φ β o Φ o o m w l M w ιn ^ ^l ιIι n ιfl (η κι σl o π o o ^f '» o ιJl lIl d N 1» N (o «ι co N ^ ^c p| ln o> ιo β m ol O O Φ ln o on-• ^o o o o ol o αl «l d o l ffi ιι^ι d ι<) ιJl d (^|) d O •^ι iD '* co cM i' H i cM in io cx) OT io r--- io in iⁱ cO "* i-~ CD cn o r- t- co io c_ cx> O H r~ ao a> a> a5 cn a> cn o cM co o oo oo a> H CO l in cM CM CM O O O σi cO l ⁱ CD cO CM

H θo r~ τ cM CM θ oo iD o ιn o ι ro ιn a> m o oo H σι <τι cΛ H "- cn r- co co o H CM rroo cmn H O c^ cM CM ro co co o ii co o co cn cM iO H in r- oo vo cM io cD C-D r.- ,1 ι _o H. . co ιι m o r- c H n o co o σ> o cM crι oo co cn cM i" CM CM H r r- ι o rθ H r~ r~ m CD OO CO CM H CO CO CΛ CM I' CO CD CN in H CM CD H m O VD H m H H CM in H OO CM m m oo o cn cM CM co ι o σ> H CΛ t t~ CM Vo co co u"> vo cΛ cM H CM Cθ cM CM r~ co r~ vo o H σι o ι^, ιn σι ι^ι co c~ H cθ '>' σι ιn r~ >o r~ cM i^ι CD cn oo cM oo o ιn cn o ιo

VO oo cn o o H CM CM vo m co m H H H θ H Cθ t-- oo c_ oo r~ cn r- cn o cn o o H ro H ro cM ro oo t~ ι~ r~ co r- CD oo co co r-- r-- ιn ι^, ro co cM H ro co o o θ H θ r- ii in in i i in i* " i' i ι ιi "- 'j' ", "H" i ^ι ιn 'r ι ιn ι ιn ι ιn ιn ιn * i' i^, "- ι* ι^, "-p ^, 'j' ^, ι ι ' iι ιι ^, ι ι 'r ι ιn ιn ιn ιn t » o tt β ol o

lo vo vo co io io co vo t— r~ r~ r- r- r~ r- r~ r~ r— co oo oo co oo oo oo co σi cn cn cn σv σv σi cn cTv cn σi o o o o o o o o H H H H H H H H H H H CM CM CM CM CM CM

H H H H H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM ^tt ^ft < < < tC < < < tt < < < tt < tt < < < < < < < < ft < < < < tt < ft < < < < < < < < ft < < < < tt < < < < < < < < tt ft wωωωωωωωgo oo oQogoωwωωwωwωw

B x x x x x ^ rt ^ x X rδ ≤ Λ cc pή X Hj Hd j Hj Hi j H- HH x x B a a x S x a a

C O^j C Λ Λ O^j i-ⁱ O^j rt rt rt rt rt rt rt rt rt rt rt H H H H H H H H D^j C-i O' &i ft^j α^j i-^j m m iii H rt rt rt rt m o o υ o ' »

aO S3

zoυooooυzυυoυυoozoυoozoooυoυoυooz . υooooozzυoooooozooooυυυυυozou

H in co ιn vθ H in ι~ θ "- c» o^ ι co c ιn H CM P- o r~ CM ' Vθ oo ro cD co co co o r^ ro ιo ιn r~ co cD H co oo cM io ι ιo oo io t H θ in H co ii H oo p- co m io ιn cM H oo cM <n "_ cn c i--- ιn ' ' cx> cθ "^ H θ ιn r- o co cM in "-r ii H θo r H CD o ' in H r ιn ιn < ι i' H r- H iθ H r σ> ι ιι H H CΛ co r- oo co in m cM cM _> r~ cD r- o r- i' m cM ii in cM ' in i r~ o cM H Oo m o co σι <n <n oo o cτι o r~ o cM M H co ι ιn vD ιι ιn cD CD r— oo r~ m cD r-- cn θ 'r H σ> o <n oo α} CM m r~ i ii ii ii ii in i in i i m in i in in i co cD co io co r- r^ ^~ Φ Φ Φ ^ ω ιo oo oo oo ω α) eo co oo ω c 'D oo ω oo co ol ω Ol oo co ^ α) ^ ^ ^ m l Λ ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooσoooooooooooooooooooooooooooo

H H H H H H H H H H H H H H

<ιl N ιIl B O N B Ol f• o ι Ol d <ι o o o o aι d « lO ιo ^ Ol 0 ln ιn n B » B O ^ ^• » d lO τ ln o N lll ι^,ι o ^^■ » lI) N ( » 1^,

Φ O C ffi Λ IIi m iJl N d d fl d ^ in B in r- n Φ lΛ B in w O V fl in r- n N lM B β d ^ B f l'I ^ V d N Φ B Cl n v ri m r- ilUD O N d β B o ^^ O ln •* β m ι^,^ O ln ^ Ol d » ^ι^l (O β ι^») d H ^^ (n ω d N ιn B (Λ o ιn cι Φ m ^ [M ^ d ι ^ N ι N ^Il o ln ι "|^| <' ιΛ ιη n ( ^ι ιn ^ m ιn ^ ^ ^ B m O B σ^ O N l m O ^ Λ ω o o<^l (n m B ^ n (^ f N d c^ι o "l^| "» Φ nl « ^^, "l^l "ι^, « ιn ^- B (J>

^ ^ ^ ^ ^ ^ ^ V "T ^ v ιJ ^ ^ ^ ^ "r ^ V in ^ V ιn ιΛ l fl ^ ι? lO V ^ * lΛ lO l ιϊ ^ V ^ ^ ll1 lO l lO lO ιπ ιO ιπ fl lO lO lfl l Λ l lO ιπ ιΛ lO l lO Λ θ ιn H r~ ^ι m cD r- r~ σi H in cM co cM Cθ ιn cM co o cM r~ ιθ ιιnn oo <^« rr^~- ιn r^ o ι r^ ι ιn H Cθ θ r* o ro H co n r-. ιo ι co ι^, o c r-- r^ co r oo ι^, r-' θ σ> ι^ι oo

O CΛ H O CO VO O r- CM H CM I CM H O ' in O ' CM CM H CO H ^«c~o -<n^> ~r~ a> <n o H H θ ι^ co oθ 'r co o <n o ro co co co ιo oo ι~ cM co co cM CM <o r~ oo ιn < 'r ιn oo cD ro iD θ H in ι^, r~ m cM θo ⁾ σι ιn ι^, co co i' i cD ιι cM CM i' ι^ι rι ^ ^ 4 ir) M tn co co cπ cM i^, cn ιn o * σι r ι o ι« o ιn ι c H r- "- ι* r-- ιn σv r- r^ H θo ι ι* r~

O H O o H CM H co oo r- r~ r- cD in m a> cχj cΛ cn <n o H θ o cM co co ι ι^, ιn ιn <n cD oo oo r~ oo o σι <n r~ co r~ co ιn ^, ι ι^, oo oo o~ι o σι o cn H . o CM CM oo n n in i i in in in i m i i^, i' T i^, i i ι^ι ι^ι ι ι^ι tn ιn ι m m ι m m ιn ι ιn ι* ι ι * ι τ i' i^ι ι ι^ι ι^ι ι ι^ι ι^ι ι^ι ιι ι ιι ι ιι ι ι ιinn m m in ii f i" i-- co ro '^ <n r~ ιn cΛ ιn <r

CM CM CM

o o o H H H ft < < < < < < < tt < < < < < tt < < < < < < tt < < < < < < < < < < ft tt < tt < < ft ft tt ft < < < tt < < < ft tt < tC ω ω ω ω ω ω ω ω ai O^j i-i ai ai DH C-i i rt W II) B B M B W W W B «1 O1 O1 O1 0] O1 01 01 1O O, Λ IH M1_I Λ ( B- Il1l(i W B W B B W a B W B H H

Hl ^ Hl Hl Hl J j ^ t oi u o n io oi ia rl B B X X X X B X B X a >H >H H H H ι H >H >H CΛ W CΛ CCl CΛ CQ CΛ OTΛ X B x a a a ri ri ri rH i i i ri tt ft < tt < ft ft ft 3 < 3 B tt3 f x c^ij i-i i-^j i-i CH O^j i-i αi h O^j i-^j i^ i-i Hi μi Hi H H^ Hi H^ rt rt rt rt rt rt rt rt di x Cu a a C rt > rt > N rt υzoo in co r- oo

Ii -• 1* Ii Ii cΛ cn cn cn cΛ

00 se a a a 2 22 δδδ 22 3 2 2 22

© O O O O O O O O O O O o 2aaaaa2aa2∑22aaεaaa2222aaaaaaaaaa22222 EH EH H oooooooooooooooooooooooooooooooooooooo O < ft < ft < ft ft ft ft ft ft < rt rt ft ft tt ft f ft ft tt t tt tt tt t i tt ft t ft ft tt ft tt < tt t ft t ft tt tt tt tt tt ft tt t ft it

oouυzoυooυυzυυoozuooυozυooυυoozoυoocozoυooυυ zooozooooooozoooowz ro -S»

CM 35

^® t_

CΛ

H 10 in vo cD o^ H cx> -p <n co ^ o oo 'i^, H ro c_ cM ^, i' in r~ in r-- in r~ oo cn ro o ' cn co in t^ in in in co cM co ■» Φ Λ » N <Λ d 01 N d B W Ol n m ' d CJ CM 00 in H T ^, cM oo co H o vo r- o o cn o ' O co cn r~ co oo o ii in cM <n cM i' O i cD co ro ro i CM o co cn H o cn cn ro i" O O ro r~ cn oo in o co co in co PM ι^ ιo ιo co σι cM co co cM ro ro ιn co r~ α3 p- co co α cn cn cn co ro H H Co α) CD i- α3 vo r* r~ o ro oo c» oo oo oo cΛ co m co io in co r- m o co in in co o cM H H CD co cn cn cn cn <n <n o o o o o o o o o o o o o o o o o oo o3 co oo oo co oo oo r-- r~ r^ r~ t~ ιo r- r-- r- r-- r~ r- r-- in in m in in in in co mm in m co co cD CD co r- m ooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooo ι σ^ co r w oo co ι i' ro [~ co o ιn o < ιn ι co σ r-- r H cM cn co cD CD i^ M i o M o r~ r- r r~ ι> r~ H co cM r- CM θo oo tn oo ^ι oo ιn eo co co co ro

1. 00 CD 1' CM C0 C O 00 O «-r^, in CM 1^l O <n ii 00 C H H "- 00 1^, CD 00 Cr> r~ C0 H C0 Cn H O 0D CM r~ lO H O lO CM CD co cM to co σi H i cM <n σι co <n t~ H io oo co co cM cn oι r~ ιn o ιo oo H θ H r~ cn cM r~ ιr) co ι^ι cn cM ro co H ιn oo ro <n co cM H ro ιn o ιn ro ro cn ro <n cM θ θ ιn oo CO - H CO CO O OO OO CM CM CO in CΛ Cn in cO O CD '

<n o oo σ^ ιn m cD CD Λ H θo θ3 θo o3 θo co crι m H H θ cn cD i~ ιo ιn oo o3 r-- θ ι '» c cM ro r "- co co c r cM ro on cn r- co cn o vo m r- in m in tn tn in in in in in in vD in in in in in in in in co iD CD in in in in Ln in m in m in n in in in in in in in in in in in 1 I

-i r-- ^, cM θ θ 'r o σι ιn H H (θ r~ CM ro cM ι <n ι o cM oo cM co cM in r- co i' r- co vo H CM CM Co oo o σι oo co vo io cM in co cM co vD CM _> H cn o r-- H in oo r~ oo r-- H CM C0 CO H 00 VD H CO CD Crι C0 00 1 r-- CD H 1^, r-- CD CM V0 CD H C0 C0 ιn c0 CΛ H 00 C0 ' l0 H C0 ιn 00 H O 1ι in <M CO t-- -> m θ OO lO C CO H H m lO O H H CΛ "- ro r~ co cM co cM c~ o r-- CM θθ o r~ cM H CM H Co cn cD θ c_ ιn ιn cM ro o ιo o oo σ> cD ^ι cM θo cM in co ιn r-- H o oo <n r~. o o cθ H CM oo cM CM Vθ ιι ιn o r-- oo oo cn H

00 o oo oo r- oo oo oo oo co vo m o o o cn cM H O cn oo cM CM oo cn oi oo cn t- Φ Ol Λ Ci σi O d Ol B O O B B Φ r- l v ^' V V q' ir ^ ^ ^ fl iri ifl in ^' tfi lΛ lO iJ' ^ lO lO ^ ^ V ^ if ι* ι ι^, ιι ιι ι ιn ιn ^{, ,} ιn m 'r -r in in m m m m in in in in in io in in in in iⁱ i in ι- o σι ιn <M co <n ι^, co ro - ι^, CM oo i' [--. ^ι r^ co cM H θ co cM σι ro oo cn ro vD H m cM CM iⁱ cD o in ro vo ii i co iⁱ n cM r- o in H co cM r~ ιo ιo r~ r- oo cM θ r^ cD co o vo ιn t~ r~ (» ιn i" r-- co co t vo o H oo H σι ι cvi cM co ιn ' ' io co ιn ιn o cM CΛ ρ- m co co r~ oo θ H θ. CM θ ι« cn co ι cn cn ( CΛ H o oo in co o r- cM cn cM co vo o H ro vo m H i' r^ cM ro cM in r- oo oo o o o ' m co co i co co H O ii CD O Cn cM CM CO VO CM VO r- H O O H CO O H H O O m co in co cn o cM CM H O O CM ro ' in ro in cD co r- r~ r- H CM CM H co co ro o CO cM o m ιo r~ ι~ r- co ιo m m f- r- oo σi o o o o cM H O O O H cM co cn

CM CM CM CM CM r CO CO CO cO rO CO CO C CO CO CO C CO C C rO 1i 1i 1 1 li li

o o o o d d d d d N n ι<ι ι¹l ι<) (o n ι^,l f) w » '» v v ff ιn co co co co ro co co ro c ro co co o o ttftft< <tt*t<<< fttt<<<<<<<<<tttt< < tt tttttt<<<<<< ft <tt<mmmmmmmmmmmm mmmmm mm t iΛ Hoυooo o rt r- co cΛ θ H CM ro ^, ιn co r-. oo cn o H CM co ' in cD r~ co cn o H cM co ιι ιn cD r- co σ> θ H CM co ι ιn cD r- oo o*ι θ H CM ro ι ιn cD r- oo cn o H cM ro τ ιn vo r-- oo cn

O O O H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CO rroo ccOo CcOo CcOo rrOo CcOo rrOo CcOo rrOo lⁱ lⁱ l i ", 'τ ιι -r ιι «-r ιn ιo ιn m ιn m m m m m vo ιo vo ιo vo vD VD vo vo vD o o o - o o o o i θ θ Ω OO-ι rO->O oOOιOrO-> fO~ιOι rO» rO-» rO-ι fO-» <O-"ϊ ιo—- ι ιo-— ι ιo-— i ro--io ^~io - ι ro-, noro-ϊooooooooooooooooooooooooooo rH rH rH ri H H H H H H H H H ve εa a ε εεaaaε εεaεεaεaaaaaaaaε aaaaaaaa aaaaaaa ∑ε∑agasasaaagaaaaaa

© O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O fS O O O O O O O O O O O O O O O O O O O O ft rt < < < < < < < < < < < < < < < < < < < < < < < tt tt ft ft < < ft ft fH ft tt < < ft < < ft < < ft ft <

oo o υ υ υ z o z z z o oo υ o o z z υooυo υ z o z z z o o o υ o o z o u o o o o z υo o υ υ o z z o υ o υo o z z o o o rt rt ro __

JM β © CΛ

H •gi o in o co co o oo cn o co r- CM CM r- CM co oo < cM co ι o cn ιn cn r~ r~ o cD cn ιι <Λ cn <D ro ' θo co ro cM CΛ cn r^ r~ co ιn θ ι~ CM * <n r- ι^, ιn ιo o cΛ r- υ o co oo H H oo cΛ VD cn co m oo i' cn in oo o o ιo co H co ro i' θ vD ιn ι r- vo o cn r~ H i o m ιn co o cM H Co r- co co cn r^ en ιn ιn r- CM H CD r-- H oo

BM r~ oo oo m co H H CM O H r~ r- co cn oo o o H r~ r~ co r~ ιn cM CM CΛ θ H H C_ <n o cn c_ vo cD H 'r ιn cD ιι CD ιι r-- oo σι <n r^ oo r~ crι cn cn crι cn o H H H θo r r--- in co in in in tn in m in Ln in i in in in in in vD io cD L i in ιn ιn ιn ιo ^, ιn ιn ιn ιn ιn vo ιn tn ιn ιn cD vo vo vo ιo ιo cD io ιo ιo ιo co vo vo ιo ιo ιo co iD r- r~ r- r-- ιo vo vo vo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

o o ι»l (M N B v (^ι ιIl ^ ^ c^ O v o ^ ι»l 1^l d o o ^• l " ^ n Φ d ιn t" d ^ d B Φ O σι fl N ^ B (^) O N 9 l Ol O O ^ o w ln r• ιIl d o cn cM '* oo ιθ ιn o θ 'r ιn r~ ιn cn en ιo <θ '|i ιo ιn σι cM in o oo cM cn o o ιι ιn co co co ιι CM H co vD ιn cn H H <n o ι^, co ιx> H H CD ιn ιn ιn o ιn co α> ιθ H io o

(^ι n ^ ιn B Φ ιIl ι») ι^ lπ "ι^ι c^ (^l "f CΛ ιn m o o B ιn o d ^ β B d d O ln o ιn d r- <ι^, Φ ω Φ ιn ln σl <Iι IM <M N B O O Ol ^ r• ι^τ) n β ^ d o in m o H H H O H CM CM H ", O O O O H CM eo ^, cM H co co ^, m ιθ ιn co m m c- oo co r-- co ιo co r- oo θ H I I I I I I I I I m m m co m ro ' cD _> -i r~ o τ CΛ m m r~ i' CΛ C— cD © vo ιn o m '^ CM CM H co ιn vo cM "- ι' r-- cn r-- cn σι ro σι ιn <τι oo o o H ro co o oo o oo o r~ H oo cM i' co

CΛ CΛ _> O ιn CM H r-- CM CΛ cn θ VO θ r- CO CO CO ιn θ CΛ H l CM CM CM cn H CM vo co co ιn H vo r- ιn o c 'r co ιθ H in co '^ r H co H r^ ι r~ r-. oo r-- ιn o en r- r~ CM r- cD c H cM iD _> m ro _> m _> f O CM f CO CM Oo co ' CM Co m o io "» d ^ ιn ιn N Λ ω oι m n ( ( ιn ιn ιn d "i' (>ι t~ σι m ιη θ N « d B n h θ (n cn

H θ H co i" «- m co r~ r- cn oo oo oo r~ r- r- r- oo oo cn cΛ vo m n cM co o H CM co H H cn cM co co co i' ' in i' ^, m ι^| ιn ιn «- io co r~ r- vD CD m ιo i' oo oo cn cΛ r- l tπ in iπ iπ io i i i io ir ^ ^ v ^ ^ if ^ ir ^ ^ * i T ⁱ i in in in i in i i i i in tn in i in in in m in in in in i in i in i i in i in i i in

|1| N

0)

c<ι H m m m m m m m m m m m m m m m m m m mmmm m ω m m m m m m m m a m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m o g g g g q g g z z z z z z z z q o i-^ Hq Hq Hj Hq HH HH- tf X rt cs e- i-H rij z z z z s z z z z z z z z z z z HI HI HI HI pS pS OS tf tf ei tf tt tf Λ W C CΛ Λ Λ nϊ Oή pS OS oS OS tf tf Oή qS Λ ft ft ft ft t ft ft f tt ft < ft < < < < < fζ ft ft tt ft et ft ft ft ft ft > > > > > > > ^ ^

H CM H CM H CM H CM H CM H CM

6o o Q ω N a B ft m o a a m o Q w csi x x m o o ft « co co m O a a ft m o Q a rt o υ o o z υ z Z Z υ υ o o o o z z υ υ oo o o z υ z z z oo o o υ υ o o o u o υ z u o o υ υ o z o υ o υ υ o z z υ o

O d c^ι ι^,) ^ ιn ^ o m o H N ιη ^ι' ιn Φ ^ o ⁽Il O ^{( (} ^» lll '^ι <Λ o H ι n ^ ln Φ <D Cl O c^l (^,^ « Λ ^ lJl O ⁽M (»l "l^l ln m o N l"r•^^^^^^-^ m BBBBCIlmlIIO\01(»ιmιι)l(IllIllJlfflOOOOOOOOOO d d dH HNMNN( N(MNN^II^,ll^,)n OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH

00 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH rH V0

2 2o2o2o2o2oooaoaoa2o2o2ooa

O oo2oaooao oaoaoo 2oo52oo22o2o2oo2o22o2o2o2o2oo2o22o2o2o2o2o oaoaoa2oo2oaoaoa2o2o2o2o2oo2o22o2oaooa o < ft < ft < ft ft ft ft < < < < ft < ft tt < < < ft tt ft ft ft tt tt tt tt tt tt ft tt tt tt tt tt tt ft tt tt S ft3Sf3 S3 S<3 <S3 S<3 S<3 <S3 S<3 St3 S<3 S3 S3 S<3 S<3 St3t St3 S<3 S<3

Table 4

ATOM 1133 CB VAL B 212 14.785 59.994 8.133 1.00 67.35 C

ATOM 1134 CGI VAL B 212 15.791 59.537 7.087 1.00 67.33 C

ATOM 1135 CG2 VAL B 212 13.789 60.957 7.503 1.00 66.47 C

ATOM 1136 N LYS B 213 12.350 59.049 10.465 1.00 63.78 N

ATOM 1137 CA LYS B 213 11.880 59.307 11.827 1.00 61.90 C

ATOM 1138 C LYS B 213 12.570 58.335 12.778 1.00 59.48 C

ATOM 1139 o LYS B 213 13.009 58.715 13.866 1.00 58.25 o

ATOM 1140 CB LYS B 213 10.360 59.119 11.922 1.00 63.24 C

ATOM 1141 CG LYS B 213 9.551 60.117 11.096 1.00 66.28 C

ATOM 1142 CD LYS B 213 8.053 59.861 11.206 1.00 66.69 C

ATOM 1143 CE LYS B 213 7.264 60.822 10.327 1.00 66.77 C

ATOM 1144 NZ LYS B 213 5.829 60.439 10.227 1.00 66.50 N

ATOM 1145 N ASP B 214 12.664 57.079 12.352 1.00 56.30 N

ATOM 1146 CA ASP B 214 13.302 56.043 13.152 1.00 53.09 C

ATOM 1147 C ASP B 214 14.816 56.184 13.114 1.00 49.43 C

ATOM 1148 o ASP B 214 15.497 55.934 14.107 1.00 48.27 o

ATOM 1149 CB ASP B 214 12.897 54.660 12.642 1.00 55.83 C

ATOM 1150 CG ASP B 214 11.399 54.413 12.750 1.00 57.66 C

ATOM 1151 ODl ASP B 214 10.834 54.665 13.838 1.00 57.31 o

ATOM 1152 OD2 ASP B 214 10.793 53.961 11.751 1.00 58.37 o

ATOM 1153 N VAL B 215 15.338 56.595 11.966 1.00 45.60 N

ATOM 1154 CA VAL B 215 16.770 56.767 11.807 1.00 44.22 C

ATOM 1155 C VAL B 215 17.346 57.816 12.758 1.00 43.86 C

ATOM 1156 o VAL B 215 18.345 57.562 13.430 1.00 44.52 o

ATOM 1157 CB VAL B 215 17.117 57.143 10.360 1.00 43.83 C

ATOM 1158 CGI VAL B 215 18.617 57.350 10.213 1.00 44.99 C

ATOM 1159 CG2 VAL B 215 16.657 56.041 9.429 1.00 46.16 C

ATOM 1160 N THR B 216 16.714 58.984 12.835 1.00 42.82 N

ATOM 1161 CA THR B 216 17.217 60.035 13.712 1.00 41.68 C

ATOM 1162 C THR B 216 17.180 59.558 15.155 1.00 40.38 C TOM 1163 o THR B 216 18.121 59.782 15.919 1.00 40.92 o

ATOM 1164 CB THR B 216 16.390 61.352 13.591 1.00 41.64 C

ATOM 1165 OG1 THR B 216 15.206 61.258 14.387 1.00 42.85 o

ATOM 1166 CG2 THR B 216 15.992 61.603 12.149 1.00 40.73 C

ATOM 1167 N LYS B 217 16.090 58.892 15.520 1.00 39.71 N

ATOM 1168 CA LYS B 217 15.932 58.371 16.871 1.00 38.63 C

ATOM 1169 C LYS B 217 17.064 57.411 17.236 1.00 35.12 C TOM 1170 o LYS B 217 17.544 57.413 18.369 1.00 32.67 o

ATOM 1171 CB LYS B 217 14.590 57.646 17.004 1.00 42.48 C

ATOM 1172 CG LYS B 217 13.393 58.572 16.969 1.00 48.85 C

ATOM 1173 CD LYS B 217 12.093 57.817 17.224 1.00 50.93 C

ATOM 1174 CE LYS B 217 10.903 58.768 17.218 1.00 52.56 C

ATOM 1175 NZ LYS B 217 9.633 58.065 17.555 1.00 53.57 N

ATOM 1176 N LEU B 218 17.477 56.592 16.271 1.00 32.67 N

ATOM 1177 CA LEU B 218 18.551 55.622 16.482 1.00 32.18 C

ATOM 1178 C LEU B 218 19.886 56.328 16.639 1.00 31.65 C

ATOM 1179 o LEU B 218 20.659 56.006 17.536 1.00 30.79 o

ATOM 1180 CB LEU B 218 18.638 54.648 15.306 1.00 30.41 C

ATOM 1181 CG LEU B 218 19.718 53.570 15.339 1.00 26.12 C

ATOM 1182 CDl LEU B 218 19.499 52.659 16.520 1.00 26.45 C

ATOM 1183 CD2 LEU B 218 19.671 52.771 14.039 1.00 28.84 C

ATOM 1184 N VAL B 219 20.166 57.280 15.757 1.00 31.46 N

ATOM 1185 CA VAL B 219 21.417 58.015 15.853 1.00 32.60 C

ATOM 1186 C VAL B 219 21.466 58.673 17.242 1.00 32.42 C

ATOM 1187 o VAL B 219 22.508 58.701 17.893 1.00 32.49 o

ATOM 1188 CB VAL B 219 21.507 59.077 14.737 1.00 35.95 C

ATOM 1189 CGI VAL B 219 22.780 59.917 14.893 1.00 37.54 C

ATOM 1190 CG2 VAL B 219 21.497 58.385 13.379 1.00 35.28 C

ATOM 1191 N ALA B 220 20.318 59.171 17.691 1.00 30.69 N

ATOM 1192 CA ALA B 220 20.186 59.809 19.002 1.00 31.19 C

ATOM 1193 C ALA B 220 20.382 58.804 20.140 1.00 31.91 C

ATOM 1194 o ALA B 220 20.742 59.174 21.265 1.00 30.98 o

ATOM 1195 CB ALA B 220 18.801 60.440 19.125 1.00 28.27 C Table 4

ATOM 1196 N ASN B 221 20.136 57.531 19.848 1.00 30.80 N

ATOM 1197 CA ASN B 221 20.261 56.498 20.864 1.00 31.97 C

ATOM 1198 C ASN B 221 21.549 55.694 20.723 1.00 31.15 C

ATOM 1199 o ASN B 221 21.739 54.673 21.377 1.00 30.13 o

ATOM 1200 CB ASN B 221 19.055 55.578 20.800 1.00 33.04 C

ATOM 1201 CG ASN B 221 18.673 55.058 22.142 1.00 37.25 C

ATOM 1202 ODl ASN B 221 18.517 55.829 23.087 1.00 38.33 o

ATOM 1203 ND2 ASN B 221 18.514 53.743 22.249 1.00 39.86 N

ATOM 1204 N Lεu B 222 22.425 56.178 19.856 1.00 30.64 N

ATOM 1205 CA Lεu B 222 23.709 55.557 19.609 1.00 31.59 C

ATOM 1206 C Lεu B 222 24.774 56.559 20.047 1.00 33.54 C

ATOM 1207 o Lεu B 222 24.679 57.753 19.748 1.00 34.13 o

ATOM 1208 CB Lεu B 222 23.858 55.266 18.118 1.00 31.84 C

ATOM 1209 CG LEU B 222 23.960 53.842 17.562 1.00 32.43 C

ATOM 1210 CDl LEU B 222 23.326 52.794 18.478 1.00 29.84 c

ATOM 1211 CD2 LEU B 222 23.292 53.866 16.202 1.00 31.79 c

ATOM 1212 N PRO B 223 25.785 56.100 20.789 1.00 34.21 N

ATOM 1213 CA PRO B 223 26.819 57.049 21.209 1.00 34.42 C

ATOM 1214 C PRO B 223 27.514 57.665 19.989 1.00 35.75 C

ATOM 1215 o PRO B 223 27.888 56.949 19.049 1.00 34.36 o

ATOM 1216 CB PRO B 223 27.759 56.190 22.062 1.00 34.97 C

ATOM 1217 CG PRO B 223 27.518 54.775 21.556 1.00 35.82 C

ATOM 1218 CD PRO B 223 26.041 54.747 21.314 1.00 34.53 C

ATOM 1219 N LYS B 224 27.660 58.991 19.998 1.00 35.36 N

ATOM 1220 CA LYS B 224 28.309 59.711 18.897 1.00 38.46 C

ATOM 1221 C LYS B 224 29.735 59.206 18.791 1.00 38.58 C

ATOM 1222 o LYS B 224 30.443 59.479 17.829 1.00 39.76 o

ATOM 1223 CB LYS B 224 28.344 61.216 19.182 1.00 40.17 c

ATOM 1224 CG LYS B 224 27.035 61.801 19.670 1.00 44.14 C

ATOM 1225 CD LYS B 224 27.237 63.221 20.168 1.00 47.87 c

ATOM 1226 CE LYS B 224 25.980 63.755 20.843 1.00 51.17 C

ATOM 1227 NZ LYS B 224 26.174 65.142 21.361 1.00 52.59 N

ATOM 1228 N ASP B 225 30.132 58.468 19.815 1.00 40.23 N

ATOM 1229 CA ASP B 225 31.456 57.890 19.951 1.00 41.59 C

ATOM 1230 C ASP B 225 31.577 56.525 19.244 1.00 39.50 C

ATOM 1231 o ASP B 225 32.676 56.097 18.888 1.00 37.57 o

ATOM 1232 CB ASP B 225 31.726 57.712 21.448 1.00 44.75 C

ATOM 1233 CG ASP B 225 33.193 57.637 21.777 1.00 49.61 C

ATOM 1234 ODl ASP B 225 33.918 56.837 21.145 1.00 54.59 o

ATOM 1235 OD2 ASP B 225 33.620 58.376 22.687 1.00 52.53 o

ATOM 1236 N TYR B 226 30.448 55.847 19.045 1.00 37.50 N

ATOM 1237 CA TYR B 226 30.445 54.514 18.442 1.00 36.48 C TOM 1238 C TYR B 226 30.892 54.451 16.991 1.00 35.68 C

ATOM 1239 o TYR B 226 30.374 55.169 16.143 1.00 35.54 o

ATOM 1240 CB TYR B 226 29.053 53.886 18.560 1.00 37.65 C

ATOM 1241 CG TYR B 226 29.037 52.396 18.288 1.00 38.60 C

ATOM 1242 CDl TYR B 226 28.039 51.822 17.500 1.00 37.85 C

ATOM 1243 CD2 TYR B 226 30.007 51.556 18.842 1.00 37.09 C

ATOM 1244 CEl TYR B 226 28.005 50.440 17.270 1.00 38.79 C

ATOM 1245 CE2 TYR B 226 29.986 50.179 18.621 1.00 39.41 c

ATOM 1246 CZ TYR B 226 28.981 49.626 17.833 1.00 38.69 c

ATOM 1247 OH TYR B 226 28.957 48.268 17.607 1.00 39.90 o

ATOM 1248 N MET B 227 31.838 53.562 16.706 1.00 36.10 N

ATOM 1249 CA MET B 227 32.356 53.406 15.351 1.00 37.09 C

ATOM 1250 C MET B 227 31.756 52.198 14.641 1.00 36.12 C

ATOM 1251 o MET B 227 31.842 51.066 15.123 1.00 33.71 o

ATOM 1252 CB MET B 227 33.881 53.290 15.382 1.00 41.32 c

ATOM 1253 CG MET B 227 34.600 54.437 14.688 1.00 48.18 c

ATOM 1254 SD MET B 227 33.881 56.053 15.088 1.00 54.24 s

ATOM 1255 cε MET B 227 34.682 56.402 16.647 1.00 56.04 c

ATOM 1256 N ILE B 228 31.156 52.454 13.481 1.00 35.08 N

ATOM 1257 CA ILE B 228 30.521 51.416 12.683 1.00 33.44 C TOM 1258 C ILE B 228 31.320 51.080 11.425 1.00 33.56 c o o o o o z o o o o o υ z υ υ o υ υ υ o z o υ o o o o o z z υ υ o υ o υ o υ o o o z o υ o υ υ υ z o o o o o o z o o o z υ υ o rt ro

H ιn ιn cM H in ιn cM vo co co OT ro cD CD ι-- ι~ ι cD i^ι -. co r- vo o o H θ co H in cM r~ vo r~ co co o ιn ιn i' oo cn H 1^, CO ιn θ l01' 1" 1' 1¹ CO O CM Cn oO CM CM CM Cn vO CJ <n r~ lⁱ O C r^ CM CM <n cM CM <n c~ lⁱ H H 1ⁱ 1 CD CM VO CM CM CM CO O H 1 CD OO VD CM r r0 1ⁱ r~ 0 1' CM CM 1 1' CM CM H i oo o m ' o in H cM f H OO OD O CM CΛ CM '-- PM CM H θ θ oo ro ιn ιθ ι< co cn ιn ιn ιn r- r- ro ro t-- H oo H in 00 O H r~ o o oo o H H O O H O H co ^, i co c>) ^, m co r- r- r- io m io co m co <M CM H ro ro co ro cM co co co co co ro ro co ro co co fo ro cM co co » m in ii in in i in in in in in in i in io in in in in in in in i in tn in i i in in in in in in t

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

HHHHHHHHHHHHH ri rH rH rH ri rH rH t- CM cn o ", CM co ^, H θo ro ιn ι^ι co o ^, cM <n [~ cM CM "-ι co co H r~ cn H H co c αD CcnΛ ccoo rr~~ ccoo oooo ccMM ii'' CCMM ccnn <<nn croo ιn cΛ ιrj cM θ θ oo ιn H in ι oo ID o CM CM r- cn i- c_n. -' ,co, m c in cn H H oo co co o co co cn oo in in ro H oo o r-ⁱ ao cioO H^H _'ⁱ _ⁱⁱ c_oJ omo cmn o-» v_o oero» vD CJO -n r cn vO lO H O O r o o cn co i co oo cM in

VD CM ιn cθ CM H Cn r r--. rt--- ccMM rro cn cD ro H H CM θo co σι ro H H ro CM i^, CM in cM in H θ <o r~ o en ιn ' θD co oo H CM f r- VO O CM O CM

O CM CO H Cn 00 00 O H 0D r~ lO m m V0 1 1' 1 1ⁱ r0 CM H CM r0 CM r0 1^, rM H O O CM H CM O H O O O O CM CM CM rO I' rO CM CM CO CM CO CO CO I I I I I I I I I I I I I I I I I oι ιπ •)^| ^ ln ' ln σl B O d B (Jl co ιn ι ιη ^ B ιo O r^ ^ » n o ^ B O N O l Φ ι5l Φ Φ d N O O^ ιn ^ P) <^ n lO O ιn n θ fl lI1 0 d KI B r^s r- m d d d d N I^ Φ P- l'| l. p- N B σι ι|ⁱ » Φ B (O θ m θ H ι « n ιn ι n N lA o ιλ N ι H ι o ω H n of ιn v ι « o Φ N ιA 4 d σi B d N d θ N n n d N r N θ w ιi) ιn ιn Φ iιi ι(i "r ri ( « d θ i!i oo ⁽ CM CM CM CM co io co i co co co co co co co

B B O B Si in at A n oi oi o o o o o o o o d d d ri ri d M n N N N N N N N N N N n n n n n n n w o ^ w v in i'i in i w w iii -

CN CM CM CM CM CM CM cM CM CM CM CM ro co ro co co ro ro ro ro co co ro ro ro ro co co co co M M M mmm m mmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmm mmmmmmmmmmmmmmmmmmmmmmmm

W W W W B Λ Λ Λ Λ rt ai rt O D D D D D D B in iO W M W n tO lO Ol lli Λ Λ Λ lϊ Λ Λ pJ Λ llJ Λ lϊ J i J iH Hl J Hl O O O O O O O H rH H rH H EH H EH ^ ^rΑ X X X X U a a W U U U a X X X l$ tt < l£ (( (( lϊ te Bj di βi iϊ Λ Hi J Hf j ω iim . ω _

H H H H H EH EH EH EH H H H j Hl H^ H^ Hl J Hl Hl Hl Hq Hl HJ H3 H H3 HP HP EH EH EH EH EH EH EH EH EH EH EH EH > > > > > > > 0< α< l4 l-l &

H CM H H CM m o o Q < m tt m o Q Q o υ υ o υ υ υ o o υ rt m QWN f m QQWMN ft z υ o o o o o υ υυoυυυυzzoooυυυooooo m

OOO O zυ <υo mo oo ^Qozooozo <oo

CΛ θ H CM ro ι^, ιn co r^» oo cn o H CM co ' in vo r- oo cn θ H CM co i' in co r~ oo c^>ι θ H CM co ι ιn co r~ oo m o H CM Co ιι m -> r~ oo σ> θ H CM co i' m vo r- oo cn o H ιn co ιo vo vD CD iD io ιo ιo vD r- r-- r^ r^ r^ r^ r^ r^ r^ c^ cD θo c» _j oo oo co co co c_ cn cn cn cn cn cn cΛ CΛ cn cn o O O O O O O O O O H H H H H H H H H H CM CM

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM^'CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM ro ro m co ro co ro ro co co co co co co co co co ro co co co ro

00 H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H HHHHHHHHHHHHHHHHHHHHHHHH se

2

© o2oo2o2oaaooaoaao2o2o2oaoaooao2o2aoaoaooao22o2o2oaoaooaoao2o22o2o2o2o2ooaaoaoaoaoaoaoao2o2o2oao2oo22o2o2oo22oo2o22oo22o2ooaao O ft ft ft ft < ft ft ft ft < < rt tt < < ft < ft < < < tt < ft < < < ft < < < ft ft < ft < ft ft ft ft < < < < < < < < < ft < < < < ft it

oo cΛυ z ooooυoo zooo ooυzooooυυυzυυoυoυ zoooυozoυoυυzoυzzoooυcΛzυ υoυoυ rt ro ,._.

© © £

H ιo r- m o co ι~ CM CM Co ro o _> σι ιⁱ H θ CM H r-- r- cΛ H i VD CM H H in H CD i' cn r^ ' oo o cn cn o oo oo oo oo co ro H rM iD ro cM OO co cn cM -r vo oo H -o CJ O H O cn H in cM n ro cn m ro cn iⁱ in co ro H OO H ro ro ^{i i} CM ^■ 0 ^"0 O ^_ CM H cM CO H oo r- cn oo i- O H vo co -i H ro m o o co o cM CM cn m oo ro m co

PM ro in oo i^, ro co H CM i^, co co vo en r~ r~ co vo m ii CM r- O Γ- o oo in o o σ HHOOHCM1^,1"1""-fmι ιnιn1' ^,cDιnmo ^, 1- H O ιn m ιn m m m ιn m ιn ιn m ι 1^, "T in ι* •a* co ro iⁱ ^^ ^3* *_"*-* ^-^ ^*-* ^_" *--^■ ^-1" ^_* *Q* ^-1* ^J* ^3* ^J* ^J* ^_* ^5* ^-f ^T* _ _ 1* 1* 1* ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H cn r~ ι^, ιn r-- ' CM Crι co ro co vD σι oo t~ H in ιn H Cθ cn H in r- o ' co H co r- oo ιn ιn o r-- r- cn in oo CD H H in CO CM O r Cn lO O _> . CM CM O C CM H r- O Cn

H in oo vD co cΛ cM CM CO co in ro in oo iⁱ in in cM CD O CM r^ σi o oo co oo i' ' in co H co , r~ _ιn. H min oooo HH ro o vo m H co oo o H r- co oo o o o i' CD o σι oo H θ co ii <n <n in m cM in in H co ^, ro in r- O H cn oo cn c_ o cM CM r- in r-- cD ii r~ cn r- CM VO t— T _> CM ^_I' CM 1^, m H 00 O CD 1" vo H io iⁱ H oo co co cn oo m r- oo vo o m c H θ θ (θ co i' ^, CM CM CM CM in co cD cn ιo ιn co r- cn σ oo oo cn cn oo o o cn cn cM <M H cτι oo cΛ θo oo oΛ θ H O H CM co ro -r i -n o o oo oo o H r- vo m i m m vo

I I I I I I I I I I I I I I I I I I I I I I I I I I I H H I I H H H I I I I I I H HHHHHH HH HHH I I HH I I I I I I I

I I I I I I I I I I I I I I I I I I I β B N Λ lIι o ( B N O B r■ Φ ιo β '» ιrι n ι<) Φ » » ιn o ^ o Φ « ι d ιn ι d β « n r' Φ O N lIι ιι) β ^ Φ H O oι ιn » (η ιl) oι d d ^ » oι * » d M in o r~ oo co v ιn p» co oo ιn r^ r~ ιn o ιn σv o i' in ιn co ιn ι α) in o o vo co oo H co rι) CM CM θo ιn r~ vo cM i^, ι^, c ιn θ H in co oo co o w m vo ιn c < ( ιn ιn cM

» « β ιfl r■ H O O ^ ιn n ιn Φ » Φ ι H d H n < d d * N O * ιo n » n o < o ι β β » n Φ n ^ ι ι^,) B N l (<) ιn d ιn r^• N O ^l Φ β f) Φ ro

Φ Φ ιn β m H M n H H O l H N d M n * (^ι o ft βι Λ β W r• O B r• Φ β o » » <^ι n Φ β » O M H (^|) ι^,1 ιn ι<) ιn "^ r1 n N « ιn l N H O n * ιn oo in in in in in co vD VD io io io io co cD cD vD iD io vD vo in in in in n in in in in in in in io in in in in in in in in in in in in in in in in in in in in in in i^ tn ( B O ιn c^l ln β 'ι^ι β N d ln ln o ιn ln ol l ^ v n f1 ln ι) ^^ ι^,) O ιn ι^,) o ι N B d o ιIl ln B B (^ 9 B ιΛ » o o π o B O <Jl "ι^ cι σ^ cn o o o H O O CM H CM CO io cM in in o H O -^ cn H CM VO H in co H O H c io oo oΛ r^ co cD σi H r^ vo H O cg o cM ro co cM CM i' H ro H O H co H H r- in in cΛ

"r B O ln 1» m ol (^ι ^ w 9l Φ "^ ^^ p^ ι ιo o Φ -l ω < ! O ^l B "l^l l r• <Jl d B O N ι»ι ^" <Λ (O l Φ r- ι^ r- O ln N Φ m B σl d o^ o Φ o o ιJι m ^• o ιJl m cι o N <ι ^ι o o o o ^l N ι^,^ o O ^- o w N (^,l B Φ ^~ o ω B ln >r M^, ι n N W V ln κl ^ ^ O m ιIι ιIl ^ B Φ B ^ B

Csl CM CM CM CO CM CM CM CO CO CO CO CO rO rO CO rO rO C rO CO CM CM CO rO CO CO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

Φ ιo ^o Φ ^ ^ ^ r^■ ^ ^ ^ r^■ B B B ^n ol (Iι m m ol <ll <Il o o □ o o o o d d d d d d ^l (l N ^ι ^l N (^ι N N {^ι ι<) m p) n n ι^,l « « "l^| "l^| "^ 1^ι 9 c rπ r c c c o ro co r r o r ιo r t o r ιo c c o c c c ^{, i} 'tf "^ ' iι i' iι ιι ιι i' " i' iⁱ "^ ιⁱ "^ "^ ι* "V

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C CM CM CM CM CM CM CM CM CM CM CM CM CM CM W mmmmmmmm mmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmm mmmmmmmmmmmmm r_tJr_tJ Jr_t irJ J_tDwDwwawDωDwDωDωD OαOαO O O O O Pβ i i β l- β n w w W ffl W lO ^βl B n iO B n iO W

U _tr α_osi-i_tfxωωωωωω 2 > > > > > j Hi H j Hi H3 j Hi o. ftι c-ι αι c-ι i_ι CLι Λ w cΛ C a x a x x x υυoυ υ υEH EH EH EH EH EH EH < o m o Q z υυ o υ -j υ υ o υ υ υ o H CM co ιn iD r-- oo on o H CM ro ι^ι r-- r-- r~ r- r-- r-- r-. r-- r~ r~ oo oo c}o oo oo n ro ro co co ro co ro fo ro ro co co ro co H H H H H H H H H H H H H H H a222aaa2 ooooooooooooooo < tt tt ft ft ft ft ft < ft < < < <

ozooooozooooooozooooozoooooooozooooowozoooϋoozoooooozooooooozzo

io o r~ <O H o r - oo r~ r~ ro H θ θ ιn cn H in cn cn ιι co σι ιθ i' co ιι ι ' o m 00 CM CD M I- m H co c r- ro r- oo r» oo co co cM CM (O CD CM ^, r- ro cM θo r- <n cM co H co co r- Ii CM CO 00 H CM O o cM H iι θ H <n σi H co ro oo r~ m co ιn cD co cM in ιn ιn ιn ro ro m ι^, cM θ H co ιn t oo r~ <n o in in in in 'f i' ro co ii co co co co co ro ro ro ro ro ro ro co ro co ro co co co co co co co co cM co ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H

CM <n * ιn cM in ιn r * vo σ» H H in α3 [~ o <Λ r^ c^ o ι cθ ( θ ιn ιn o ι (^ ι^, cM θ ιn ι^, θ H co vo r- o r~ c o r ι oo "- '^ ( in oo o3 σ^ ιn ιι <n ιn o H r-- r-. vo m i' i' to ro o H CM H in ι^, ρ- H co ιn o o o t~ co ιn oo co oo orι cM in co r-' C in r-- o vD co H co r^ o ro co H H cn r^ cD θ ι^, ιn o ro r~ co cn <n <n ιn ιn H co oo

CO CM CM CO VO CM lO CM CO rO rO l ιn H c H cn cD m cM co cD » ' iι c CM CM r θ 'r cM in ιo ιn cM Cθ ι r~ H c co ι H iθ H θ θ C CD ιi H CM 'i^, ι oo oo ro ιn ιⁱ H H vo in CO I¹ ro O CO in m CD m r- ID ID 1 CO CO CM H 1" CO co CM CM H O O H O O O O O O H H CN O O H CM H O CM

1 1 1 1 1 1 1 1 1 1 1 1 _"-1 1 1 1 1 1 1 1 1 1 1 1 1 I I I I I I I I I I I I I I I I co m <n vo i in o cn o r- o o o m ιo co ι [~ ι 00 m ι ιn ιn ι ι

M n o o » 9 n N n ( O ι<l d π d l" B t" n N O ^ ι^ N l^ B ln « Φ oι n ^ B ^ ^ « ιJl r• d ^ N ^ ιI\ <f ^ N m l O O B r• π ιη (l B ιn d "^ n ιJι ln ^ι ^ (η d B ι«) ιfl O Φ ι») d ^ N ^ H O (^l d N ln d d ι) ι « d r• o ^, N d n αι B N N m "^ ι ^ O Φ O d m h N n o n ai ij N N n in B ^ iO B H in i n oi o n iΛ n π in in M io o n β o Λ iη iii h in 'i' in d in ^ n in B in * ^ Φ ιn v w ιn "r "f r n N N d 9 "^ ιπ v "^ ^ ^ ^ B O O m ιn ιn B Ol ^ n n ι ι o d >l' ^r ln ιn ln Φ « ^ Φ B CΛ o o o ιn "»

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CO rO rO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM W

1J fl « W '* "» "^ ln ln ιn ln ιn ln cn ιflΦΦ Φ ^ ^ ^ ^ » B B ω co o o co o m m m ιIl m m o o o o o o o d d d d d H H d c^• ι ^ι * ι ι ⁱ "^ 'r ιⁱ '? ιι ιι ιι ^t 'r ι^ι ιⁱ 'r ιι ι^ι ιι ι^ι ιⁱ 'r ι^ι ιι ιι ιι ιι ι^ι ιι ^« * ^ι ι^ι ι^{ι ι} ι^{ι ι} ι ιι ι ιι ι ιι ιⁱ L ιn Ln ιn ι ι ι ιn ιn ιn ιn ι ιn ιn ιn ιn ιn

CM CM CM CM CM C CMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCM^ Cl CM m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m ca m m m m m m m m m m m m

PH OH PJ {h lC_hl _tol _ai ωb3 ta_ ωa ta_ tti_i ωa ωω Ct£_ Cθ_i CO_i CC_ύ θCύ; CP_i rO, Or. rC>. _ΩΩ _ΩO _ΩB _aO ^rO ^rO _CtH ^rtH_ι^ fr^ Cfr_, _CcHi [l-H^ '< t→ rJ HH Hl rH HH rH HH HH HH HP H^ HH HH ^ Z Z Z Z D ui 04 B; tf„ l.-. l.li, d„i J hl J J J J J J B a w B a B J J J hl Hl hl J J J M B a B B rt rt rt rt rt rt rt rt rt rt rt rt rt rt Hi - - - z z _ z , z z w ω

EH EH EH EE^HH EE^HH EE^HH EE^HH H H H H H H H H CΛ CΛ CΛ CΛ C0 C0 O O O O O O O O O 2 2 2 a 2 2 >>>>>>>>>> > > > > O O O O O O O O O

CM H M ωωωcoKix et mooα tt o zoυoυυzυooυoυυzυoooo υ υ υmυQ H CM owoowz totυo mυoot- H CM υcΛO o < o o mooozo <υo mυυo m o Q w ω υ υ o υ o o o z z ι»i "j ιn Φ r- i' 'r "a" «τ 1 1* 1^, 11 H H H H H

00000 Eι tι h tι EH ft ft < <

Table 4

ATOM 1448 C LEU B 252 24.074 47.411 4.910 1.00 30.49 C

ATOM 1449 o LEU B 252 24.083 47.338 6.137 1.00 31.62 o

ATOM 1450 CB LEU B 252 23.775 49.541 3.595 1.00 26.58 C

ATOM 1451 CG LEU B 252 24.396 50.889 3.162 1.00 29.74 C

ATOM 1452 CDl LEU B 252 23.367 51.781 2.452 1.00 25.72 c TOM 1453 CD2 LEU B 252 24.940 51.602 4.403 1.00 28.99 c

ATOM 1454 N SER B 253 23.475 46.512 4.135 1.00 29.43 N

ATOM 1455 CA SER B 253 22.763 45.372 4.687 1.00 29.35 C

ATOM 1456 C SER B 253 23.689 44.541 5.575 1.00 29.60 c

ATOM 1457 o SER B 253 23.324 44.162 6.685 1.00 27.14 o

ATOM 1458 CB SER B 253 22.216 44.501 3.559 1.00 29.62 c

ATOM 1459 OG SER B 253 21.469 43.417 4.082 1.00 32.53 o

ATOM 1460 N ASP B 254 24.897 44.278 5.094 1.00 29.62 N

ATOM 1461 CA ASP B 254 25.847 43.494 5.871 1.00 31.92 C

ATOM 1462 C ASP B 254 26.192 44.203 7.192 1.00 31.13 C

ATOM 1463 o ASP B 254 26.277 43.575 8.248 1.00 25.96 o

ATOM 1464 CB ASP B 254 27.130 43.271 5.070 1.00 35.93 C

ATOM 1465 CG ASP B 254 28.066 42.273 5.737 1.00 41.42 C

ATOM 1466 ODl ASP B 254 29.303 42.391 5.568 1.00 43.83 o

ATOM 1467 OD2 ASP B 254 27.559 41.356 6.423 1.00 46.70 o

ATOM 1468 N SER B 255 26.399 45.513 7.131 1.00 28.26 N

ATOM 1469 CA SER B 255 26.752 46.247 8.335 1.00 28.88 C

ATOM 1470 C SER B 255 25.616 46.261 9.357 1.00 28.38 c TOM 1471 0 SER B 255 25.843 46.036 10.549 1.00 28.04 o

ATOM 1472 CB SER B 255 27.165 47.682 7.985 1.00 28.35 c

ATOM 1473 OG SER B 255 28.356 47.692 7.214 1.00 28.87 o

ATOM 1474 N Lεu B 256 24.397 46.512 8.890 1.00 26.63 N

ATOM 1475 CA Lεu B 256 23.257 46.563 9.787 1.00 26.15 C

ATOM 1476 C LEU B 256 22.955 45.218 10.407 1.00 26.03 C

ATOM 1477 O LEU B 256 22.582 45.138 11.572 1.00 26.78 o

ATOM 1478 CB LEU B 256 22.024 47.095 9.060 1.00 23.91 C

ATOM 1479 CG LEU B 256 22.081 48.604 8.804 1.00 25.22 c

ATOM 1480 CDl LEU B 256 20.923 49.019 7.915 1.00 25.03 c

ATOM 1481 CD2 LEU B 256 22.038 49.358 10.134 1.00 23.13 c

ATOM 1482 N THR B 257 23.121 44.166 9.623 1.00 27.10 N

ATOM 1483 CA THR B 257 22.861 42.822 10.094 1.00 28.54 C

ATOM 1484 C THR B 257 23.806 42.465 11.227 1.00 27.76 C

ATOM 1485 0 THR B 257 23.397 41.834 12.201 1.00 27.18 o

ATOM 1486 CB THR B 257 23.012 41.797 8.948 1.00 30.71 C

ATOM 1487 OG1 THR B 257 22.062 42.103 7.916 1.00 30.14 o

ATOM 1488 CG2 THR B 257 22.758 40.372 9.461 1.00 30.87 C

ATOM 1489 N ASP B 258 25.061 42.882 11.098 1.00 28.20 N

ATOM 1490 CA ASP B 258 26.078 42.619 12.112 1.00 30.16 C

ATOM 1491 C ASP B 258 25.849 43.377 13.414 1.00 29.71 C

ATOM 1492 o ASP B 258 26.229 42.901 14.485 1.00 28.76 o

ATOM 1493 CB ASP B 258 27.467 42.993 11.597 1.00 34.00 C

ATOM 1494 CG ASP B 258 27.970 42.046 10.554 1.00 38.03 C

ATOM 1495 ODl ASP B 258 27.752 40.827 10.720 1.00 40.72 o

ATOM 1496 OD2 ASP B 258 28.598 42.521 9.576 1.00 43.37 o

ATOM 1497 N LEU B 259 25.265 44.565 13.318 1.00 29.27 N

ATOM 1498 CA Lεu B 259 25.002 45.382 14.502 1.00 31.85 C

ATOM 1499 C Lεu B 259 23.948 44.734 15.380 1.00 30.57 C

ATOM 1500 0 Lεu B 259 23.878 44.994 16.585 1.00 27.66 o

ATOM 1501 CB Lεu B 259 24.521 46.784 14.106 1.00 34.32 C

ATOM 1502 CG LEU B 259 25.565 47.720 13.506 1.00 36.30 c

ATOM 1503 CDl LEU B 259 24.940 49.089 13.226 1.00 38.89 c

ATOM 1504 CD2 LEU B 259 26.727 47.858 14.483 1.00 38.73 c

ATOM 1505 N Lεu B 260 23.122 43.906 14.755 1.00 30.02 N

ATOM 1506 CA LEU B 260 22.060 43.202 15.456 1.00 33.18 C

ATOM 1507 C LEU B 260 22.669 42.436 16.621 1.00 33.45 C

ATOM 1508 o LEU B 260 22.136 42.424 17.728 1.00 34.54 o

ATOM 1509 CB LEU B 260 21.366 42.244 14.488 1.00 32.08 C

ATOM 1510 CG LEU B 260 19.867 42.456 14.273 1.00 35.36 C oozoυooυoozυυooooυzzoooooooooozooooozoυooυozzooooϋυozoυooozoooυ

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H H H H H H H HHHHH m cM VD VD cn o m co r— m m cM r- o oo oo cn o cM i' CM Vo cn p- i' CM in fO H H in vD H ro ii i co co r^ cn oo oM oo i o c- co co cM H CD H o m cM ii in vo cn co o ro co oo i' CM ^, ιn vD oo cM ro m i' Vθ cM r-- o ιι σι r~ cn ι o oo H Vθ H H H co oo o H O r_^ CM CD CM CO Ii l CD H m CΛ CO CD H CO H I' I' CM in cO OO I' CO I 'r ' m CO ii cD c in io co H r-- o c i < co oo ofi "- ii H O <n ii co cM r~ in vo H CM n ii <n 1 1' o o m cD 11 lo σ^ co co oo o ιn H r- 1' ^- CM co H C cM c H ιn ^- 1^,

^» N Φ ^ B (! ^ B Oι o d B r- ω Φ O O O O (^ O B O N N (>J <M '^' ln N d M ^ι o ιI o β f π1 uιnmιι ιΦu w ιιπn ^r• Φ* lιu ιιull ιun) fl^, ^ ιπ Φ Φ ι tΛ

H H H H H H H H H H H H CM CM H H H H H CM CM CM CM C H H CM H CM H CM CM CM CM CM CM CM CM CM CM CM H CM H C CMM CCMM CCMM CCMM CCM CCMM CCMM CCMM CCMM CCMM CCMM CM CM CM CM CM CM CM CM o cn ro o co oo in cM co o co cM co H r^ H io m cM cn co r oo H Co o vD CM O VD io in cM H in cD oo co o cn H cn o co in co ro H oo cM co co in o σi o o αr^ i cM H iO H

M ιn d P^ ιll Ol (^,l ι lIl B ^ o ιJl ιn r^ m l O w o c^ι d ( o d ιIl (Λ N B ι^,l r■ <)l (o l ln o^ B ιn ιn r■ * o o ^ Φ(>^ ^ B ιn ιn B m ιIl B O n "ι' d ln d O lι n (ι ιIl B 1lι o l Φ ιn < ^ cΛ ιJι o o o o B β o ^l B Ol 005l r■ ^ ln ιΛ N ιo ^ d f) ιIl ^ ιrl Ol ιfl '^ ^ O O Φ B co o m co oo (o ^, ii in in i' co co co i^, i" m io vo oo oo cn cn co cM ro ^, cM CM H CM CM H O O O O CM CM ro i' H <n H oo i^, in vo io co oo r~ r r-~ cn cn r- 00

—T CO CO CO lⁱ "- — r 1* 1* 1* 1ⁱ "- — T i^l * I ( p^■ O lfl B -) t» d W d o n Φ ι ιn

<n (n ιi H θ θ H CΛ

H H

o o H H H d H N l N N N N N (^l N n n o n n n n n n n n » « « » » w ιrι ιn ιn ln ιn ιn ιfl ιnΦ Φ Φ Φ Φ Φ » ^ t" ^ ^ eo o B l_ B Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ CM CM CM CM CM C CM CM CM CM C CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C CM CM CM CM CM CM CM CM CM CM CM m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m mmm m m m m m m m m m m m m mm m m m m m m

D .. D.. fc_- fc OH O- a^j CH Cu —cu . CΛ CΛ CΛ cΛ w cΛ i _-i w _ w _ M _ w w ω ω ω w . ω _ pH OH rt P- o, κ-1 ω ω ω w ω ω _H3 _H5 _H^ _Hi _H3 ω w OT OT w w w w w w ^ ^ ^ ^ r^H ^ ^ ϊH ^ B X X X x x x ω M ω

< < < < < < < < J ^ J ι^ ^ h1 ιJ ιJ lJ & lH h lH lH lH l- lH h lH lH n i IO ia ia i < < < < >i: (t < H H H H H H H CΛ — C —Λ W — C —Λ C —Λ C —Λ O O O O O

H CM a a ft o D Q m o Q w N o Ha CaM Hω CωM tκι H CM H CM H o υ z υooooooz υ o o υ υ υ o z z υυoυυυυυυυz < m Q Q o Q υ o o o o z go υmυozz fυtoo om υo υ o <υυoυ ooz totooo m P) in H Σ o EH

oooozooozυoooooozυυooozoυoooozzoϋoυooυoooozoooυozoυoυooυzυυoυυυ rt rt r~- ro !>_ JM

© O CΛ 8

H r- vo co ii CJ oo o r-- cn

PM 0 (0 <Il d

CO lO ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H _d iπ _d θ ^ ιn Λ fl θ ^ o ι* d d Φ (nΦ o o ι θ ffi "i^, ιfl c*ι σι ιo < θ» tn ιπ o ιn Λ oi ιι ^ rt (^,ι p' fo * ι v r_' V N θ ι ^ ^ o r θ ^ - 0 "l^, ιΛ Φ O v n fl ^ "f cι ιn n Φ ffl ^» "f d o ι ιn » "f ^ ^ ι o « ιn <^l N d ιn fι ^ r• Φ Φ Φ <J 9 o n » n "ι^ι n ι ι d Φ ιn » "l^, ιn ι>l _lΛ B ι ι n w ι ln ln o o ^ c^ι n N O<n d o^ (ι ι o Φ o ^ ^ ω d d m o n » ln ^ B <Il l β ιn r- oι B ^ ιn ι»l (^ι N O d ^ι ιo d m Φ ιJl oo cn o σι ι ιι ro cM ro cM CM co co cM CM H H H θ oo H o o cn oo ι cn o o oo oo ι- ιn <n oo co r~ r- vD co ιo r- vo m iⁱ r- vo m iⁱ r cM irj co iⁱ r- r cM H r iⁱ CM

CM CM CO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H CM CM CM H H H H CM C^l ri ri ri ri ri ri rH rH rH rH rH ri rH rH rH d d » » ln iD iD ι^, ι ι o " ln Φ ι v d N d ιn ln (n ln (Il B o ι ιIι ^" φ ^ι » O N B π lfl B d ιn ιfl '^ O l B ^ O (0 "|^l (^,l ^ oι o d ^• Φ σι d co » ιIl ^ >i^, N n Φ N O O n ι O n B m m N O B » ln ^ d 9 Φ β ^ o d d W !^l N B O lIl -^ O ln r^• ^^• 9 C>ι ιn d ^ll 9 « o ιn ⁽n o ^ o ιJ> Φ ι ιJ^ ^l^ι ^ (^ d N l O ιn n n ln ^ n « ^f d O l^ ^ B ln ln w ⁽Il B r^■ ^• Φ B d v v l/) v ^l (1 ( 'l^, '^^, ιΛ O d lIl O Φ ^ Φ Φ r^■ ι^| ι>l d r• ln m "f O r• o cn oo cn r- m cn o o H CM fO i co fO iⁱ ro i' in i' co i' vo r- r— r- <n σ> oo o r- r- vo ιo r- r- co vo oo vo r-- oo ιn co iⁱ c cM H ⁱ T in in i iⁱ i iⁱ vo r- t— r— cn n o

H H H H H H H CM H H H H H H H H H H H H H H H H H H H H CM

B B m iΛ m ιιι o o o o o o o o d d d d d W N N N N Ci| ( M n ( ( n π n π n n n m m « <f w v « v ιn ιn ιn ιn ιn ιn ιn ιn Φ Φ Φ Φ Φ Φ Φ Φ r" ^- ^ ^ r^■ ^- ^ ^ ^ ^ ^ r• ^ ^ r• ^l ^ ^ ^- ^ ^ r^■ ^ ^, r^■ ι^ r^■ ^ ^ ^ ^ ^ r^■ ^ ^ ^ ^,> ^

Cg CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CSl CM CM CM CM C^ m m m m m m m m m m m m m m m m m m m m m m m m m m α m m m m m m m m m m m m m m m m m m m m m m m m mm m m m m m m m m m m D D D >π ^H < r^H D O D D D D D D P, ! α; p. O, P, Z Z Z Z Z Z Z Z X X θH θH p, P- X θ5 « « « rt « « « « « 0- j j j j j _hi j j w a B a i- a w M B M W M B w ιo ιβ M ra ffl w w B >< ^ >ι >ι >* >< >ι >< >* < >ι ' i. H a w w B J J J J J ιi J J α Hi ιi J J ιi Hi

O O O O O O O O J j Hl H^ Hl H^ Hl H^ CΛ CΛ CΛ CO CΛ CΛ rt rt rt rt rt rt rt rt EH EH EH EH EH EH EH EH EH EH EH EH CΛ CΛ CΛ CΛ CO CΛ H H H H H H H H H H H H H H H ι»| 1»Λ Φ n nP1n Φ Φ Φ H H H H

∑a∑∑∑∑∑∑ aa∑∑∑∑∑∑∑aaaa∑∑∑∑∑a∑aaa∑aa ∑aa22∑∑aaaaaa2222aa 2222222222 © OOOOOOOO O O O O O O O O O O O O O O O O O O O O O O O O O O OOOOOOOOOOOOOOOOOOO OOOOOOOOOO tH EH H H EH H EH EH EH H H EH EH H EH EH E-i EH o S EH EH H EH EH H EH ft3 S<3 St3t S3 Sf3t <S3 S<3 S -H ft3 ft ft ft ft ft ft ft ft tt ft ft ft ft ft ft tt tt tt tt ft ft ft ft ft tt ft ft tt < tt < < tt ft < < < < < < tt < tt S rt3 S3 S<3 Sf3t S3 S<3 S3 S<3 Sf3t Sft3 r

TahTe 4

ATOM 1637 CDl ILE B 276 20.973 48.376 15.530 1.00 31.10 C

ATOM 1638 N ASP B 277 16.375 46.307 13.006 1.00 28.02 N

ATOM 1639 CA ASP B 277 15.697 45.216 12.308 1.00 31.09 C

ATOM 1640 C ASP B 277 14.875 45.762 11.134 1.00 31.45 C TOM 1641 o ASP B 277 14.986 45.272 10.013 1.00 32.87 o

ATOM 1642 CB ASP B 277 14.778 44.448 13.271 1.00 34.57 c

ATOM 1643 CG ASP B 277 13.996 43.344 12.575 1.00 36.69 c

ATOM 1644 ODl ASP B 277 14.621 42.396 12.063 1.00 37.70 o

ATOM 1645 OD2 ASP B 277 12.751 43.427 12.526 1.00 42.12 o

ATOM 1646 N LYS B 278 14.054 46.775 11.394 1.00 31.81 N

ATOM 1647 CA LYS B 278 13.241 47.388 10.346 1.00 33.40 C

ATOM 1648 C LYS B 278 14.132 47.982 9.259 1.00 33.30 C

ATOM 1649 o LYS B 278 13.841 47.849 8.075 1.00 33.52 o

ATOM 1650 CB LYS B 278 12.348 48.484 10.938 1.00 34.87 C

ATOM 1651 CG LYS B 278 11.222 47.948 11.806 1.00 39.50 C

ATOM 1652 CD LYS B 278 10.764 48.949 12.865 1.00 44.74 c

ATOM 1653 CE LYS B 278 9.850 48.261 13.896 1.00 47.34 c

ATOM 1654 NZ LYS B 278 9.637 49.060 15.144 1.00 49.68 N

ATOM 1655 N LEU B 279 15.227 48.623 9.662 1.00 33.17 N

ATOM 1656 CA LEU B 279 16.136 49.219 8.694 1.00 33.76 c

ATOM 1657 C LEU B 279 16.735 48.144 7.801 1.00 35.27 C TOM 1658 o LEU B 279 16.949 48.367 6.611 1.00 35.16 o

ATOM 1659 CB Lεu B 279 17.254 49.994 9.397 1.00 31.81 C

ATOM 1660 CG Lεu B 279 16.830 51.213 10.221 1.00 31.76 C

ATOM 1661 CDl Lεu B 279 18.076 51.978 10.657 1.00 27.74 C

ATOM 1662 CD2 Lεu B 279 15.910 52.117 9.396 1.00 27.79 C

ATOM 1663 N VAL B 280 17.011 46.981 8.384 1.00 36.33 N

ATOM 1664 CA VAL B 280 17.566 45.859 7.640 1.00 36.53 C

ATOM 1665 C VAL B 280 16.589 45.355 6.575 1.00 36.86 C

ATOM 1666 o VAL B 280 16.991 44.953 5.489 1.00 36.16 o

ATOM 1667 CB VAL B 280 17.903 44.688 8.585 1.00 39.05 C

ATOM 1668 CGI VAL B 280 18.312 43.460 7.775 1.00 40.46 C

ATOM 1669 CG2 VAL B 280 19.018 45.094 9.527 1.00 37.37 C

ATOM 1670 N ASN B 281 15.298 45.380 6.884 1.00 37.81 N

ATOM 1671 CA ASN B 281 14.303 44.910 5.937 1.00 37.92 C

ATOM 1672 C ASN B 281 14.111 45.832 4.742 1.00 39.69 C

ATOM 1673 o ASN B 281 13.937 45.358 3.623 1.00 40.54 o

ATOM 1674 CB ASN B 281 12.968 44.680 6.638 1.00 36.79 C

ATOM 1675 CG ASN B 281 13.007 43.487 7.570 1.00 35.96 C

ATOM 1676 ODl ASN B 281 13.696 42.501 7.305 1.00 34.67 o

ATOM 1677 ND2 ASN B 281 12.255 43.563 8.660 1.00 35.46 N

ATOM 1678 N ILE B 282 14.135 47.141 4.962 1.00 41.96 N

ATOM 1679 CA ILE B 282 13.977 48.063 3.844 1.00 43.76 C

ATOM 1680 C ILE B 282 15.178 47.930 2.908 1.00 43.59 C

ATOM 1681 o ILE B 282 15.023 47.878 1.684 1.00 42.87 o

ATOM 1682 CB ILE B 282 13.837 49.528 4.322 1.00 46.35 C

ATOM 1683 CGI ILE B 282 14.904 49.847 5.364 1.00 49.26 C

ATOM 1684 CG2 ILE B 282 12.450 49.755 4.895 1.00 46.46 C

ATOM 1685 CDl ILE B 282 14.775 51.227 5.969 1.00 52.73 C

ATOM 1686 N VAL B 283 16.369 47.834 3.490 1.00 42.61 N

ATOM 1687 CA VAL B 283 17.591 47.701 2.707 1.00 44.18 c

ATOM 1688 C VAL B 283 17.683 46.332 2.039 1.00 45.95 c

ATOM 1689 o VAL B 283 18.330 46.180 1.005 1.00 44.64 o

ATOM 1690 CB VAL B 283 18.836 47.902 3.586 1.00 44.07 c

ATOM 1691 CGI VAL B 283 20.078 47.992 2.729 1.00 45.78 c

ATOM 1692 CG2 VAL B 283 18.682 49.152 4.404 1.00 47.56 c

ATOM 1693 N ASP B 284 17.052 45.327 2.634 1.00 48.15 N

ATOM 1694 CA ASP B 284 17.088 43.999 2.043 1.00 50.89 C

ATOM 1695 C ASP B 284 16.085 43.925 0.905 1.00 51.42 C

ATOM 1696 o ASP B 284 16.235 43.124 -0.014 1.00 50.07 o

ATOM 1697 CB ASP B 284 16.816 42.928 3.102 1.00 52.73 C

ATOM 1698 CG ASP B 284 18.063 42.590 3.910 1.00 54.77 C

ATOM 1699 ODl ASP B 284 19.064 43.328 3.782 1.00 53.52 o ozυoooυoozυooυooozoooυυozooooυυoozυooυwzυυoυυozoooυυυυzzυυoυzυυ ro -«5

C -ft

© "

CΛ

H CΛ CM oo m o * m CM m H co o r~ cM _ co en cM in oo co cM in co ιn ιn ιn cχj r-- H H H θθ Cθ r~ ιn cM H «- ιι ro ro cM CM CD ι CM VD ιι r- CΛ θ CM o io o oo cn r- H cn m CJ oo m » oo CΛ oo o CΛ O CM Γ- '^ r~ r~ o r H in oo cM ιn cM <n ιn o H cn co o cn cD CM CD iD co co i' θo ro o cn ro co cM θ CM in cM co cM co ι ιr) ■ o <n cM m cn m oo cM

PM Φ r ^ ^ r_^ o ci N Λ H W iii ^ Φ o ω i ^ ^ O Φ in ^ N in Φ in Φ ^ Λ ci ω B i iO Φ r^ ^ ^ ir iΛ cj N N P ^ i i io iη v v i ^ ^ ^ ιn ιn ιn ιn ιn ιn _> — > _> - — > _> _ ► ι ι vo ιn vo ι_ι vD r^ vo co vo r r^ r-- r^ ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H ^ι t1 Φ fl lπ "ι^, ι^,1 d ^ N O ιn oo ιfl d O ^ d ( ιn o Φ o o ιι ^ (M l ι^,1 σl « B ^, O lnffl M ιn Φ ι'l Φ ln d ^ o ιΛ Uι o Φ o o o c^| ln ( o o n Λ ι^, _l m ι^ι ιJ ιn <Λ _O v <^ N Φ O ^ ^ Φ o o "_f O (Λ Φ ιn 99 Φ lr) 9 Φ <^ B ^ ( ^^l) d ^- o » » o o ^ Φ ι N "^

Φ IJI _d n _W IO N l!Λ d Φ m « B Φ Φ I<l in C>HO Φ ιn lII Φ N d d d O d N β « » ^ n B n Mn « O d B O '» f1 l n B l. B

O O H CM O O CM H CM CM * O O CM CM CO O CO in CD CO CM CM O ιn r~ r~ <n vo vD r~ r-. co σι co r- vD t- co αn o r- vD co m W O H CM CO H H CM CO I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I l l l H I I I I I rH rH τH ri rH ri rH rH I

VD CO CO CM CΛ I CO O I' in cO rO H CM ' H m rO CM θ H in H r~ ^, ro i' co α> cΛ o co cM Vθ ro ro oo ιι CM oo H H CM O r~ CM H ro o co r^» H VD o co cM r~ r-- cn <n cM _> cn r- H H CM _> c_ cM iⁱ -r> cn o cn r- O H r- r~ r- cΛ cM oo H θo <n σ> ιn o vD vD r H <n cM r— " <n cM θ r-- cn cM H H "- o ro <n r~ θ H CM r~ m oo cM r~ ro r- co ιn o m r- CO I O VO CO CD CO CO CΛ O CΛ H CO CO Cn H CM ' CO CM CM CO in CM VD CO rO CO CM H in cO CM VO r-_' O CO lO CM H cn vo co co cn i— oo o cM θ θ co ιn ι ι cM ' co r- co cn

H "* m m ιn -r ro m vo vo vo m m cΛ o cn m ιι co cM ro cM i' co cM co cM CM H O O H i^, in in m co r~ i' ^, ro ro i i vD cM o o o o σi oo r- m o o H H O CM ro co co i T 1^{, , ,} T r C ^, 1 1 1 1^, 1 1ⁱ T β ιΛ B ^ M v n ^n βι (^ o ιn ιn a m ιn n ιft d ^β ^ n Φ ιn ι>l H n « n B ιn Φ N O Φ oι » ^β B N o β ι o Φ o ιn ι ^• m m (ι ιfl » o o » "» Φ ^ » "^ d H ω o B Φ ^ B O d ιn "^ O N ^ n o n N o Φ (n N π n Φ M (M ln n N ln ^ lJl n l N lM O B o o o o o r^v » β « ι n n n N "» « v o (n ^ ι/) ιn n B (iι > r- ιη ιιι ci fl M in Φ d Φ <ιi d B o τ o <r ιn d i^,Λ Φ 'i^| Φ w Φ ( B i)ι ^ d ^ ^ oo ιn ι^{, ,} 'r cM H H H in vo r- r-_' r- vo r-- ιn oo oo oo oo of> o o vo ιn ιn ιn ι ' ro <M CM in ιn vo co ι co r- CD cn cn o H O oo co oo co r~ oo r-- oo r-- ιo co cD co r~ t~ oo

H H H H H H H H H H H H H H H H H H H H H H CM CM H H H H H H H H H H H H H H H H H H H CM CM CM H H H H

'j ιn ιn ιn ιn ιn ιn ιn ιn co vD co cD co co co co r~ r~ c~ r^ r^ r^ ρ- oo oo oo oo co oo oo α> oo σι cn cn cn cn cn o o o o o o O oO H H H H H H H H H CM CM CM CM CM CO CO CO ω m ω ∞ co oo ∞ ∞ ∞ tD ∞ B co tD m ω iii ∞ αj co B co co ω ω ω ω co to co ffl αi ∞ Qj co ω iii ω i iii σi σi oi iji cji <n σ o^ c σι o^ σ» n cn cn c n cn < c cΛ

C CMM CCMM CCNN CC CCNN CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CC CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCMM CCNM CCMM CCMM CCMM CCMM CCMM CCMM CCMM MM CCMM CCMM CM C^ CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM m m m m m m m m m m m m m m m mm m m m m m m m m m m m m mmm m m m m m m m m m m m m m m m m m m m mm m m m m m m m m m m r I-i Oi l-i eH C I-i ^ αi D D D D D D D D i-g j J Hl H^ H^ H^ D D D D D D D D D CΛ CΛ C Λ CΛ Hj Hl Hl Hl Hl CΛ CCΛΛ CCΛ cCgO cCΛΛ CΛΛ CΛ CΛΛ CCΛΛ ω_ ω ω cd td ω ω ω rt rt rt rt rt rt rt r^ ri Hi HP H^ Hi HH HH HH ^ t" t" f" r" f^,, ^Nι ^N, '^, ^ ^ '¹ ^ '¹ '^, ^ ^ ^H H H H H W W ^yJ

< < ft rt < tt tt tt < ^ > > > > > Hq ^' _i_ ^"| _l- ^", HH ^" H3 ^" ₍- ^"q H ^"l H^ ^" Hq ^{" ""} O O rt rt rt o o o υ υ z totooυmoυαυwυNzzυ <υoo m z <o

O d N n « ιn o ^ B m o H ^ ι » ιn Φ β « o N n » ιn Φ ^ B O\ O H w n v ιn Φ ^ B » O H N ^(|1 ^ ιn β ^• B m o d ^ι ιn * ιn » ^ B » O d ι o o o o o o o o o o H H H H H H H H H H N C CM M CM CM c cM w M c c co co c fo co ro i' ii ii i' ii ii i i i in i i in in in in in in i cD io -) i~ r~ i-~ r- i-~ r~ r_^ r- r~ r-- i~ r~ r-- r-. i_^ i-- r_^ r~ i^ i~ i^ r_^

00 H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H rH aooaaoao∑oaooaoa∑o∑oo∑o∑o∑o∑o∑o∑o∑o∑∑oo∑∑oo∑∑oaooaaoo∑∑o∑o∑oaoaooaao∑o∑oaoo∑∑ooaoao∑oao∑oao∑o∑o∑o∑ooaoa∑ooaoaaoo∑ao∑oo∑aoo∑ao

O ft ft ft ft ft < ft ft < < ft ft ft ft ft < < tt < ft ft < < < < < < ft < < < < < < < < ^ft ^ft < ft < < ft < < < < < < < < <

oυzoooozυυoozoooυzoυoυzoυoυzoυoozoooozoooυ zoooυzoooozoυoυozυooυ rt rt r~- ro is

©

©

H ιn ιn cD θ oo o co ιθ H H CM θ co o H θ H oo co co cM θ θ ι^, cM r~ - ιn vD cn cn cD o H i ιo r~ σ5 iι r cM i^, oo cM CM Co r* c c-- ιn c 'H" CM Co CJ lO lO H OO fl in β OO ι~ oo H t-- o ι CM H r~ ro (D CΛ ro H H ro ιn o ιn r~ θ H H H i ιn ^, co vD r~ r~ co co vθ H in o H CD Co co r- co o H CM CM θ ι cM O co ιo oo

PM 1» » ^ ^ φ ^ B B m ^ m o o o o o d H d H ι ι^l N l N N c^ι n ι ι n (0 (0 (^ ι<l ( ιo (o ι ( (O M ι n H O σl Ol O B "J^, 'l^, Φ () o r• o σι cn cn m cn σι cn cn <n cn cn cn cn o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o <n cn o σι <n σι cn cn cn σι cn oo oo cn

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H ri rH rH rH rH

N d d N ^l d ιn o ^ o d o d <Iι N O O N n B ^ ιI\ fg π ^ ιn ln (^,l o o ιn ^ <Il ^J d ιIι O B ^ N ( ln ^ "|ι n r^,l Φ ι^,l O ^ (^,l ( <^l ( cθ ", cM cn vo r^ ι^ c θ r oo oo co cM θ cn r- oo ι* c^ o^ ι ιn H '^ ιn c ι <n c ιn ιn Lθ r^ oo 'r ιι cN _' cM in vo oo r- r-- c r^ r■ ^ O N B Oι f^ o Λ ι » ι^,) n N O ln o B O ι»ι o o N (Iι ol B ι^,Λ « lO d 0 ^o ^D » d n d O Ol d o r> ι^,) d ^ » ι<l ln d ι o ^ ιO B « l') d B O n d lJl Φ ^ ^ Φ Φ Φ ιn ln ^ ^ B O ιO ιn Λ «1 ln * ι>l O M d O o o d O ιJl B ^ o ιn B r" Φ lIι ol ^ r- (n ιo < <^| ln o ιι d O O d d O O d

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H I I I H I I I I I I I I I I I I I I I I I I I I I I I I

I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

H r~ CM CΛ VD co o cΛ H r» cM ¹ r- ι ιn © i' vo co o θ ι^ r^ o cθ H H H VD r~ c» H r-- ( 'r co ro ι^ι cD H in r o o ιn o^ co cn ιn cn ι cM oo r~ r-- ιn vo co r- o o cM θo n ^, c r H n _ⁱ cn in in M O i cM i r^ m i c.N>i 'r o ιn cn co r-- r~ ro r-- ι^, 'r oo vD o^ r~ vo cM t^ r~ H "- CM θ ιn r^ ι^, H in oo oo σι co o cn cn cn oo ro o H H Vθ r~ ιθ H lo iD io cM in r- in co r^ ro o H H in co -r o COo H O VD 0 H 00 H H H VD σ> C0 ιn ιn C0 r-- CM 00 H O ιn ιn ιn θ CD l 00 lX> CM H 1ι r0 O O C0 H CM O C0 r~ in C0 'lι 1ⁱ 00 o

N "r n (^ "» "f M ιn ^ O\ B O O O o ιJ^ B O ^ ιn v ιn » ιn » 9 ιπ ιft r^■ ^ ι^,l cl d » (^,l c>J n "l' ^l (^ ^ ul ιn (^ c^ι Φ ^ B cn

^ <^,Λ O Φ "f 9 00 ^βι ^ "l' <J o O l^1 ιn ιn <^l r- ^ o o^ <!Λ σl d N B O lIl B lJl oι Φ * (^,l "^ ^ ι ι^, ^| B N « ^ W ^ lJ Ol n "ll ln o d "r 't^ ^ B π ⁽*^ ιn ^ oι m ^ Φ d o^ ^ d W N w o ^ B B ι^,Λ ^ f^,^ O c^ι ^" N ^ ^ B ( 1J O l ιO r' ( ιπ Jl ιn o ιO σl Φ ιn d Φ c ! ^ ιn ιΛ <Λ ιn pι ^ ln l ffl n N O ιn o m o ^ n Φ ι^ ^ ^ι o » 0 "r N ^ o ιΛ n ^ n o ιη v lO N m ^ ol c^l ln ιn ι^ι αl O H d ^ ιIl ^ ιn n d ln σ^ m ^ m _ m ^ ιΛ m d H m c^ι n τ n "r v ιn * ^ ^ B ln Φ ιn ^ B σl cn m o H ^l ( O N M (^,1 N ιn « "f n (vι ^ v ln Φ f1 lfl W ln ^f

H H H H H H H H H CM CM H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CO CO CO CO CO rO CO CO CO CO CO rO CO CO CO π

n π » "f ^ ^ « ln ιn ιn ln ln φ Φ ^ ^ ^ ^ B ω o m ol m ^βl ιJ o o o o o d d d d ι ι < ^ι ι^ι ι^,l (o m (1 n ^ fl' ^ « "» ^f ln ln l ) ln ιn n cn σ^ σi n cn i i σi σi σi cn cn cn σΛ cn cn σi σi cn n σi σi σi σi cn cn σi cn cn cn cn cn o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C CM CM CM CM CO rO CO rO CO CO CO CO rO C^ m m m m m m m m m m m m ^{~ ~} " " ^~ - - - - - - - - - - z

< <

ooz υooϋo oooz o υ oυ υ υ z o o o o oo z o z z z υ u ooo υ υ z υ o o υ ooυoo o z oϋoooozϋ ϋooυυ z rt "tt t- ro

< 4 « o ,<_ o <

CΛ

E H? cn ι_* co ιn cn co oo _> CM r- m σi o o co vo cΛ CM co r- vo cM in o CO H I* H vo oo co I¹ H r— oo * υ cn cM in r- co r~ H oo ro CΛ oo cM o m r- r-- r~ H H cn ιι ιn cn cM cn cn co co o co co oo t- ro CM co oo

PM H CM i' θ Vθ ιn cM ro ιn ιn ιn ιo <n ιo ι θ H CM co cn vo ιn o cN 'r ι--- CD CD oo cM α> vo r~ r-- ι--- oo ιn oo r~ o r~ r- _' oo m co ro ' i i CM H H <n o H o cM CΛ <n oo c_ c~ r^ c» oo o3 θo cD r- _ι co vD r-- r~ r-- vD ιn ιn n co vo co co co co cD ιn 'r ' i" i^, 'j' i^, ' co co ii n iO fo m m ro ro ro ro ro ro ro co cM co co ro ro ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H i σi r- M r- o o cM i i r- in r- co ii r r- o oo ro co ι ι o r-- H CM θ i' θ co <n H <n cn r H cn ι ιn ιn cM co H CO H cn r- i r- cri co o cD o oo co ii oo oo H oooo ιioo oooo ιi^,' rr^~- '-ι"' <<nn cc»o coxo) ccnn HH co_o ccMM imn ccoo ccMM iinn H VD co cD cn o H ' σι <n ιn c 'r r-- cn cM co vD σι r-- cn oo oj vD θ θ CM IO Γ- OO OO OO CTI O C VO Γ- OO CM CO CM O H VO o vo ii cD D co in co i in ", O H c» <n H CM CM oo o H a3 r~ n io t~ o vo o M O co <n o ro vo i oo in H r- c σi m cM o oo o H O O io i— r^» o n m cn M H o H CM CM H CM CM H CO I- ιn ιn ιn vo n 'τ vD vo a3 oo ιn '* co cM H CM θ cn o o cn H H co cM o o H CM σ^ oo r-- r~ co ιn ιn cM co co H "-p co 'i ι^, ro cM H in ιn ιn cM

I I M C ∞ d ifi in iη φ iii N o » m « » r' θ d

B Φ O B B Ol σι (Λ o o d B o σι o ^ Φ O d N n (^ ^ « ιn ln _N (n » ιn n ^ι cι d « ι ln '» ln ln "f m ^ ^ ^ c ιIl cιl ^ Φ ι^,Λ 'r ι* '* 'i^, _' "-r ιn ι ιn ι^, ι* 'j* ιθ "-p -ι^| ι ιθ ι ιn ιn ιn ι ιn uo ι^ in r- σi ⁱ cM co in oo cM H O co o cM co co H o CM CD θ H in ιn o ιn vo c H co ι~ ro ιn <n H < cM r~ r-- co cM co c| vo co cM CM H in ι^ι vo cD vo co c r- ' r- H in r-- vD cM oo H i' 'j^, cM ' <n co co oo cM cn co iⁱ cM CM <n r~ ι^, cn cM co ι* ι^ ro ιι vo H co o ιn ιn o o 'r o ιn vD co H CD ιn ιn oo oo ιι ιι r- n r-- H <n <n ιo ιn θ H ι^, cn cn cM <n cΛ iⁱ co H <n o H O O o r- O H co i-- <n vo o cn r r-* cn H o r~ vθ "* H H in oo co oo o ι^, co ι^, ιι co co <n cM θo σι ιn cn ιθ ιn cM Co cn H r-- ro cM ιn r~ oo ιι c_ H vo ι CΛ θ co ro r~ r~ r- co cn o r- Φ Φ ^ '- ^" t- ιΛ ιl^ l09 l Φ Φ ^ Φ ^• ιn "f ^^| "r ιn Φ t^s ιll N d o o d d N N N O o B O (¹ ^ ι(l ln Λ Φ Φ co co ro co ro co ro i co co co ro ro co ro co co co co ro ro co ro ro ro co ro co co ro co co co ro co co co co co co co co co co co co co cM CM io cM co cM C^

in ifl Φ Φ Φ Φ Φ ^ ^ ^ r- r- B B m mω ω oi oi oi m ci σi oi m o o o o o o o oo o o d d d d N N N N N i N Pi

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O H H H H H H H H H H H H H H H H H H H H H H H H H H co ro r co ro ro io ro co co co co ro ro co ro co ro io ro ro co co co co co co co co co co w mmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmωmmmmmmmmmmmmmmmmmmmmmmmmmmmmmm o 0-θ«DHHqH^j la^joHqDH5DHHDH3_HH)HDHqθ-o0-oXoC_ol_oΛoXo|-5oPήortorto«oPgoSortoH<o2oDDDDDDDDwωωω6Qωtaωωωω«o-cr-o.θH fci-_J o oo uoι^Λ-<.--j.^ι-ιajrtrtrtrtrt rt moo z o υo υ oo z ^ ffl m O d (^ι n 9 lfl ^ B <Iι o d ^l ( » ln Φ ^" B ι^ O d N m fl lIl Φ ^ β cn o d N n » ιO ^ O^O N ι<l V l Φ ^ <n o d ι ι»ι <I' l Φ ^ ιI) cM C C C ⁽θ <o c r ⁽o ιo c ' ' ι^ι i' 'r "-r ι^ι ι^ι ι^ι -r ιn ιn ιn ιn ιn Λ

CO CO CO CO OO CO ∞ ∞ OO O OO CD CO CO ∞ ∞ ∞ CO CD ∞ ∞ O ∞ CO OO ∞ CD OO OO CO OO CD CO OO ∞ CO CO ∞ ∞ CO CO

00 H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H se 222283222 222 ∑∑∑ε∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑ Σ Σ 22 Σ Σ Σ Σ Σ Σ Σ Σ Σ

© O 2OOOOOOOOO2OOOO O- O- O- O- O- O- O- O O O O O O O O. O _ OOOOOOOOOOOOOOOOOOOO O O O o o O O O O O O O O

^" O ft et < < tt < < tt < < < < ft ft tt ft < tt tt < < < < < < < ft ft < < < ft ft < ft < ft ft ft ft ft ft < S t3t S <3 S3 f St3 S <3 rtrtrtrtrtrtrtrt it

oooυυυoozυυoυυυoozυυoooooooozυooooooυoυzυυoυυυzυzzzυooooϋozϋooo r^ ro JM

© © CΛ

H ln co m CO CO CM CM OO O VO H OO I' l CM CO CJ (Il o H CO O CM - CO VD H in cM in rO CO cn

PM vo m r~ © oo co vo io in io vo co cn ro vo oo ii cM ro cM o o co oo r- vo σi co co cn o m i' ro cM in H CM O CM H ιn H i^ι ι CD r-- ιo σι oo vD vo σ> o r- ι ^ι o cM co ro ro 1 ι ιn ιn ιn ro n ro ro co τ -r i- co co co co co co cM CM CM CM CM Co co c 'r ro ro ro co co ro ro T ' ι* ιn ιn ιn ιn ιn ιn ro ro ro ro co ιι co ι ro co ro ro co ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo rH rH ri rH rH H H H H H d ιll ^■* ln ^ 9 « fl^, ι^,lNι

N Bn lnπ ln θ ιr> CM ro _> r- co σ> d » o ιn 09 - CM o Φ θ dd i N d « σι lo in vo co vo vo covD -p

M O ιΛ B B O lJl n o ιn σl O ^ Φ o ^ m cα d d B ιn ^ ι)^ o o π ^ o lπ M ln π ω ^ l ln o B d N ιΛ N O N O ln ιn ln ⁽Il lIl n Φ l0 o o lO ι ro <n ιo ιn co co r- c vD oo cM θo ιn ιo ιι ι H θ n H H c ι ιι vo ι o Λ r oo o c in M H r-- «τ c ιn o ro <n ιn c r~ <θ H H in <n ι c r~ H C ω ^ ιn d n ^ d d ^ ιn •I O ^■* ^ι Λ n N * m B n d n n o ιJl a lβ "l' d B d o n o ι^ N B ^ o ι ^ "^ Φ N d * ^ o n N O Φ lIl ^ ιJl ιn ι»l ι ^ ι^ ιn ln ιn ^ B ^ m ^ B ^ ^ ιΛ O d ^ι N l ln Φ Φ ^ ln v ln ^ n N d (^l N (O m d ι ιη ιη » ιη » ^J ιn ιn ^ ln ln ln >» v ^• Φ ^ n ι d O d

CM C CM CM CM CM CM CM CM CM CM CM CM CO CO CO CO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

o υ o o o o z o o o υ o o z z υ o o o υ o z υ z z z ooo o o z o υ o υ o ϋ o z oo o o o o o z υ υ o υ z υ oo o o o o o o o rt rt f- ro

© ©

H cM Cθ _ ιn cn vD H C~ r-- ιn <o cM -> o r-- CM in ιι co ιn o co ι ι* co r-- ro ιn t~ co cM Vθ cM VD c cM i^, <n r~ H oo ιn ιn ιn cM r- σι ιι ιn <n cM CM co H cn ro iD H H CM cM cn cΛ υ H r- vD Vo r- in oo r- ii cM OO H H m cM CΛ O in oo o oo oo co i oo oo ι^, CM Co cD <n ι cD co ι cM cn ιn o m oo H ιn ιo m H o oo o t- H m m oo ιn cM H cM CD i' co cD t-

PM cM in cM CM H CM in cn H σι σι cM co ro ιn o H θ ι^, H in σ< H H CM CM c ιn ιn θθ vvoo oooo oo oo oσΛι oooo oooo σσιι ccMM ii'^, imn rroo rr~~ oθ H co i_n. o _o c -o. o_ .r- H . . co vo r- ro rM H CM H CM H < c r f p ro r ( ι^, ro f i^, i' i^, v ι ιn ιn ιn vo co w r~ r~ r- ιn ι ι ι ι,nn ι,n ι,nrι ιion vion ι,rι ι,nn ι,nrι in vion cion vmo vion vion pr--. f-. f-. CO CO C~* CO [— [*— P- ["— - ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H lΛ β lΛ « W IO n » H H » n <l^l H O β β d O O « ffl O ιn d d β « lβ « N N ^> l^,1 ll) O H H O B r^■ <^l » lll l⁾3 β l l^β ιn H B H O n O l^l1 B β W

O N α n N n n N ι»ι o N Φ d n Φ o ιΛ ι ( Φ ιn ιn N Φ n d O_\ Ol d σι "l^ι ^• d O O d N » ^ Φ ι^,Λ o n ι^,l Φ ι Φ B lIl N n

B ιn d Φ N O d ιn o N π ^ (Il ^ β V "f l v l Φ Φ n d N O B d N d O d |11 I^I N O O ^ ( (Il B N (I C^I O B O <l^l ^ Φ l O O\ Λ 0 001 C>^ ln d ιn B ιn m vo m vo vD < r cM H ιn ι co H o o H θ H H CM o c i' o o O O O O H CM H O CO O H I H O O O CO I¹ in vo m m r- in T I* in m T

I I I I I I I 1 1 1 1 1 1 1 1 1 m d I 1f "» 'J m n o « ^ ol w o o d v ιJl B N d lIl O Λ N O ffi O B o n "l^, * (^ β M (^ι ιn Φ O ^ Φ φ ιn Λ o ^ O ffl N N d N B <ι^ι lIl n Φ O B ιn ffl m M Φ ιn l c^ι l N (Λ N B ffi ^ Φ o O ( "J ^■- ln ι^,l ι») ^ ι O ιΛ d O β ι») <) <» Φ N Φ B ^ι ιn tι1 d <ι^| o t!Λ ^ι o d n m w "^ ^ ιη B ιn ol ^ B ιn N "f ^ ιn ι ιn ^ ^~ B O ^ "f N τ^ O ( l ln ιn <» (^ B B ^ w N Φ ω Φ O B ιs d ι^,l ιn n o ( N O d o !J> ro n N <> d m N Φ ^" ^ B ^ lIι B ^ ιJl o o d d N ιn v « 'ι^ι « ^ » ιn ιΛ fl « n Φ ^ B O\ m o ^ Φ ιn ιn Φ ln « l/) "ι^ι (^,l <^>^ M d Ol c^\ ιn ιn ιn tn ιn ιn ιn ιn tn .n tn ιn ιn ιn ιn tn ιn ιn ιn vo vD VD ⁱo _> _> ιn ιn ιn ιn ι^

CM r- o cM oo r- r- H o <n «- in co r- cn oo H io io r~ r- i- v βl B d r^, ^ lf) l l N *O O h m Λ in r. 'O l/l fll ^ fl o o «mι vo uooι ωoo vo ιcMι O H v ιr-- oo oo cM oo oo H H H 'r cM ' in ro cM r- o cM co o H cn i' O i' r- ιn "f o _ ι _i H in o r~ cD (o ιn "-ιι cM CM Cθ in r-- r- oo ιn oo cn "-r oo ι ccMM θO oO oo rr--- θO HH HH CCMM ccnn ιmn ιinn oo eo o o r~ r- m m ro ro r-- VD σι o ro oo θ ιⁱ H i^ι ro r- <n H co oo σi oo oo cσΛi oooo ιi^ι' oo mm <n ιn H in <n co r-- oo o vD H io o ιn ι— oo H oo ι ιn oθ ι-- ιn vo ιn ιn σι oo o 1" oo ro in

O O Cn CΛ GO CO O O- CΛ CΛ CΛ GO r— cn H H H O CM C0 1< 1 m i- V0 H H O O CM C0 Cn c0 [- VO ["- r- r~ r~ r-- r-- ι--- r~ co co co oo cn oo c_ o r~ vo ιn ιn co oo CD oo r- oo CM CM H H H H CM H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H H H H H H H H H H H H H H H H H H H CM H H H H H H H H H H H

σt A θi σt aι m o o o o o o o o H H H H H H H H H H H C ⁽M CM C>ι c4 <o to < r r <^ (θ r i' i^, i' πr ι^| ι^| '9 i^| ι ι ιn ι ιn vo ιo tø Φ iø cø vø vo ιo ιo <_'

H H H H H H CM CM CM Cvl CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM W CM CM CM CM CM CM CM CM CM CM CM CM CM ro ro ro c co ro co co io ro ro co ro co ro io ro co co co co ro co co co ro co co ro ro co ro co co co ro co co co co co ro co ro co m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m ω ω ω ω ω ω z z z z z z z z o o o o .- tf pi Q. '-. ^

X X B B X CΛ CΛ C W C < j C CΛ Cή tf ≤ 2 X θS « pύ tf W ω ω W W W ι^ H3 H} H3 ιJ .J J C_ CiH Cιj t_ l-ι Cb rt rt rt rt rt rt rt rt rt rt rt rt rt rt rt rt rt rt rt Cn CΛ CΛ CΛ CΛ CΛ H H H rd H rd rH H o N

O υ

z o υ o o o υ υ z z υ o o υ o o o z υ υ o o o o o o o o z o υ o o o υ z υ o o o o o z o ϋ o υ z o o o o o z o υ o υ υ o o o z rt r^ » ro

JS fit

© ■S

©

CΛ

- H? r- ro r~ co t- o CD CΛ CM ιι ιι ro co •» J r- r- co H CM CM t- CΛ H ιι oo cfi H

PM n ι> m ro ιn ιo vo co r-- cn cn cn H m

_ _ ot co co φ oo ccι <n vo o _ o_ o_ o_ o_oooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooo.ooooooooooooooooooooooooooo

HHHHHHHHHH m t— ιo ιn r- <n cM <n ro H θ co ι— vo * o w p N « ιn o^ co B ι ιΛ N ^ n ιrι o <>l <»l ι^ « "ι^ι N v n <^ ffl B ln ln lfl B H ^ N d <^ι ^ <» <⁾\ o^ r•

H θ r~ 00 1 H VO VD lD CM CM CM T H cn co ' vo vD CM r~ <n H Cθ ι CM H ιn ιn <M σ^ o ιn vo ιn ro vo co θ 'τ 'i^, o cM oo oo co o <n cM H 'r σ> <o co ' co ιn r- cn ιx> ιn r~ m H H CM O VD in H H CD r- m CO CΛ H θθ C θ oo o o cn r-. o o r- r-- o <n H ro ιn cM θ ro cM rθ H θ vo cM ro cM H CM θ H ιn vo oo vo <n r- o o oo ι' θ CM H CM θ CM cD r- oo on iD io in vo m r- oo cn cn i— r- ι— m o O CM CM Cn O O CM O CM CM CM m vo ι r 'j ιn co ιo ιn vD r- ιn (^ t~ oo oo r~ cn o θ H O O 00 00 O H H O CM 00

I I I I I I I I I I I I I I I I I H H H H I rH rH r- τH rH rH ri ri rH ri ri ri ri rH rH rH rH rH ri rH ri rH C4 <Si C^ C CMS CM CM CM H H CM CM CM CM CM H

I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I ll^lnw ^ldnc^ldOBBιn^■

"5" cn ι l/) ol 0 B n d β ιIι φ ffl N ln ιn lO B O (^,l (O B O Φ ι» (S d σi N r" O N d ιn ι m ι co cM H VD r- co σι oo ι-~ co r-. [— oo r- r-. σι σ> o o H H H r- vo r*** r- in 11 m oo αn H H O oo o H co ro m cM co i' ' in co co ro co i' co H H m σi σi m

H H H CM CM CM CM CM H H H H CM CM CM H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H H H CM

^ ^ ^ ^ ^ ^ B (O B B B B ffl B oι oι m ι oι ιIl ιIι ι^,Λ Ol (Jl (Jl O O o o o o o d d d ι ^l (^ι N ι ιη ι^,ι n ι^,) n n » <ι^, « » < ^^l » » » ιn

Cg CM CM CM CM CM CM CM CM CM CM CM N CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rO rO CO rO CO CO CO CO CO CO rO ro ro rO rO rO M ro co ro ro co co co ro co ro io ro io co co co ro ro ro co co co co co co co c c co ro co ro co co co co co co o ro ro ro ro co r^ m m m m m m m m m mm m m m m m m m mm m m m m m m m m m m mm m m m m m m m m m m m m m m m m m m m m m mmm m m m m m m m rH C- 0c; « X X !- D C- D D D D !_ D O- CΛ CΛ CΛ CO CΛ CΛ O O O O O O O O O EH

H CM H CM H CM H CM H CM ft B O Q B N ft m Q Q < B O Q Q H W N o m ft m υυooυυozzυoooooozoυoouυooooz ooυozϋoooooz rt m rt m ft D H ω u o o υ z o o o o o z o o o o o o o o z ιn D r~ CD CΛ θ H c rθ 'r ιn co r~ cι> c o H CM ^ 'r "- i' i' "-r ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn vD vo vo vD io vo co v^ o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o CM CM CM CM CM W

o ∑o∑o∑oaao∑o∑o∑o∑oo∑o∑∑o ∑oo∑o∑∑oao∑o∑o∑o∑o∑oao∑o∑oo∑∑o∑o S rt3Srt3Srt3Srt3Srt3Srt3Srt3Srt3Srt3Srt3Srt3rtS3 S ft3S<3S<3Sft3S<3S<3S<3S3St3tSft3S<3S<3Sft3Sft3S<3S<3

oooooυzoυoυozυυoυυoozυυoυcΛZoυoooozoooooozoooυ zυooooozoooozoooυ

?^■ --Λ-

£ o cM θ <n ιn oo r- r~ oo co cM θ ι^, CM i" θθ H co σι io σi 'r co co vo <n cD C CD CM in oo ιn ro oo ιn H CM oo oo cM co cM ^| ιn CM VO c r- n H CD H O io oo ⁱ r^ H r-- υ i O H H m r^ iO ri m o o ιn r~ co ιn ιn r~ cn o co cM CM oo o ιn cM ro H CM in ιn co r--_' ^, H vo vD ιn vD ii ( ι < ro m H vo i m co cΛ in c i' oo i o M

PM 1ι C0 C0 1^, C0 r0 O 0^ 00 CO O H lO VO VO VD ιn 'r ιn CM ιn r-- r- VO V0 0^ r-- C0 CD ι~ CΛ CΛ O 00 0> H H 00 V0 [~ CM 1ι ιn C0 ι cn cn oo oo cn cn cn r- co in m co ro H Oo oo cM cD CD iD iD iD CD vD m in in vD vD m in in in in in in in m m in in in in in in m in m m cD in m co io m m in cDVD vD co vo H H H H H H H H H H H H HHO O H

OOOO OOOOOOOOOOO O. O_ O_ O_ O_ O OOO OOOOO OOOOOOOOO OOO O OOO OOO OO O O OOOOOO O OO O O O O o o o o O O O O O OO O OO O O O OOO O OOOOO OOOOOOOOOOO O O O OOOO O OO O O O OOOOO O OOO O OO

vo oo oo cM co in co r- co co O H vo oo in cM co r-- cM CM r-- ^, © cn c'i, vo co co ii in H > cM i^, CM H CO H Oo oo cM cn o iⁱ vo Cri H H O VD rO CM ' r^ O H OO OO H O CM CO co cn in ro io cM m co i' IΛ, C _n. θ M N B B ttl m >li |~ Φ d σi r" <Λ B r- in fl' d B N N 111 V d lΛ IIl d O B IIl B '* m cM t-- m m -i m co ιn o o rθ H m co H c~-

H CO Iⁱ OO CΛ in iⁱ in CM CO CcOo CcMM i' H vo oo m oo cM OO H i- H O in cn co H co ro cM co m o co cn cM H r- oo o co r- r- co C0 H C0 r- 1< C0 O 1^, H l0 I~ CM O 1 <O 1^, 00 r- r- oo m m m vo vo co in m ' vo VO "-r cO Vθ m cθ 1 "- CM CM H CM CM CM CM H CM C COO CCMM rrOO rH O O O cn oO OO CM CM fO CM f fθ H θ co i' rθ H o σι cn o cn oo r- co r-

HHH H H H HH HH H H H H H H H H H H H H H H H H H H H H H H H r ro ro ro co co co co co co rM CM Co cM CM cM CM rM I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

CO H CM O H *«* C H H CM C_ 1' C_ f CO H m r~ O 00 1" 1^, VO CΛ '- O CM Oo c p- iD o^ H in r- CM m o cM H O oo in iⁱ r-- oo m i co cn cn cD r- co cM CM — ' 1' VD i' in ιo cD CM i H iι r-- CM Co cn cD o cM oo ιo oo ιn H CM <n cM θ in m ι~- σι ιn H in co oo m o H O H CM i' H H cn in m co o rO H CM CO OO VD H H r- OO O H in vo vo cO OO ιθ > cΛ co oo oo r--- ι "-r CD ιn cM θ r-- i' CM co cD oo co ι^, CD o <τι iD CD cn cM in <n H oo cM co cM i^, m o co co i r- r- O H H CO I m CO OO r- H H I' CO H -p in

<j <n oo a) r^ co o^ <Λ CD r~ o o _) r-- ιo r~ p- oo oo oD in ιn ιn ιn ro co iD CD oo cn ιo ιo ιn oo o o o θ H θ H H CM H θ O H H O CM CM C0 H H CM C0 H C0 1¹ 1¹ 11 11 cn in in in in m m in in in in vD vD in m m m m m m m Ln m in in m m m in m m m m m in co vo co co cD VD CD CD iD VD VD ro ro ro co co ro co co r ro ro ro ro ro co co co co <n co ιn cM Cθ ιι cn H co cn cM " Cθ co iD o cM CM "-i' in σ. o _ o _ m o_o_ c_o_ co o _o σ_. o_o c _o r .~ o _ r.- o r~ o m i' iD <o H H m H o. o > H cn iD m i cD c CM

_> in r-- H CM H CD O o cn ⁱ r-- H i < <nn rr~~ oo rroo oo rr--- < σni iiⁱⁱ oooo oooo rroo HH ccoo ccMM CCMM CCMM OO CCoo ccnn iinn ccoo cM ro H iⁱ r- ro in oo CM co σi r- oo i iO H O io m ro ro cM H O i cD r ι~ ι <n o H co cM ^, cM cn ιn cM H ^ι r-- ι cΛ CΛ cn c vo ι ιΛn orno Hri i«>^ι ιιnrι ιr----. ιιnrι σrιι ι»*ιι ι«ι^ι H--ι θr-. ι lD θ r VO CD r*** lO r~ r-- CM θ ro co ιι o ιn co crι r- o o oo ιι ιn r- r-- ιn ιn ι oo oΛ o cΛ o σ H CM CM H co ' in co cM CM i' CM θ ιn vD vo ιn r- oo ι--- r-- r~ <n o r- r- io cn o o o m - i in -O i i co c C H O co r M in CM CM CM CM CM CM CM CM c cM ro cM ro co co co co co ro ro co co co co co co co co co co co co co ro i ro "-r r c co c ' 1 1 CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM

l/⁾ ln ιn ln ιn ln Φ « Φ « ^ ^ ^ ^ r^• ^" B B B B B ^(l^ ⁽Il 0l 0l lI1 lIl ⁽Jl O o o o o o o d d d d d lΛ 0l ι^ ⁽n ι>l 0l (J\ o o o o o ro r co co co r co co ro ro co co co co co co co co co co co ro co r (O ro co co ro ro ro ro ro ' "!r 'r i' iⁱ '_' i '-ⁱ iⁱ iⁱ 'r i' i' 0 0 00 ro co ro co co co co co ro ro co co co ro co co ro co ro ro co ro co co ro ro ro ro r ro to co ro co io co co ro co co ro co co ro fo c^ m m m m m m m m m m m m m m m m m m m m m m m m m m m mm m mmm m m m m m m m m m m m mmo o o o o o o υo oo o o o o o o

P^ tf O^ CCi Oύ X X tf X . C-I X CU ll OLl Cll C^ PlH ^ ^ C Λ CΛ Λ C H. H^ H^ H^ H. H^ H^ H^ PC Z Z Z Z Z Z Z Z Z Z x x x x x x ω ω ω w ω c- w cΛ CΛ C CΛ C ^ ^ ^ ^ ^ ^ rt rt rt rt rt rt rt rt rt rt rt rt rt rt ω ω ω ω ω ω a a x x a a CΛ CΛ OT CΛ CΛ CΛ CΛ CΛ CΛ CΛ _H EH EH EH EH EH -o -o OT -o -o o_ rt rt rt rt rt rt rt rt o o o o > > > > > > > > > > > > > > w OT W OT OT OT -H EH EH EH EH fH ft ft ft ft tt ft < ft <

oozzυυoooozυooυzυooυυoozυooooozoυoooozoooυυυυzzυooυυoozoooυυυzo

o vo oo i¹ 4 "r B Φ _> m cM -p n N iO d O Φ Φ d -l o in CD H -Λ oo o co H m in c-- CM H H CM H H CM H CM H H H

O O O O O O O O O O O O o o O O O O O O O O O O d ^ fl d O ln ln Λ d cn ln B o o ιΛ ln d ^ ln m o ι ι n n ι»l N ^ d ^ β ^" Φ -) Φ O d o o Φ r• <Il -l '» n m ιn ^ r> Q d l n d « ιtι Φ d d ^l (<ι ιι ιn ( r-- ιn co H θ θ cM t~ o o ιn co cM ro co r-- θ 'y ' co cD in r-- CM CM σ. cM " H in ιn co σι H VD oo ιn r H co cM cn ιn H cn ιn H Cθ cn o ro cM r^

Ol B n Φ N ιrι< ι^,)ι- « d » ιη o o ιll ^ X 1. ^^ d ιl B N r• Φ B r■ r' V ι^ ι^,l O O O d Φ "l^{| ■■} O ι!l N « ^ O π ^ "- o^ Ol ll) d ^ co ι^,l ω m o ^ Φ ιn 1. Φ ∞ "^ ι. l d ι^,l ^1 ^l (^l (o n c^ι v ι»l »ι^l ι^ ι ιn Λ (^l d OΛ H ι o o <I^ » B ^ ^ B O o o o N ι o o ιl ol d H l1) B

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H CM CM CM CM H H H H H H H H CM CM CM CM CM CM C^ ffl ιn d ι « « o •* ^ -)N H N n d "l' <. ιfl d ιn ι»l O B « l m ^" ι l ( n o ln lO (^ v a l Φ l Φ ι») ^ ι!l N N m v n ιη c^ι ^. (^,l ιn d ι^,l ln d '1f ιn n o o ln ln N ^^,) ^ ιn Φ O ιJι ιfι d ln ^• ιn n d Φ -) -) B d -l o ω ιIl ιn r• d B n ι r• ιn o o o o ι»l Φ d lfl p1 ( d ι o ιn <Il B m ^ ^ o π ιΛ « o w N ln o ln (^,l (^ι ι o ιΛ ιΛ d d v B o o ^ (O ιn <Λ ιn ^ f^ ιO (^,ι ^ Φ ι. o n ^^ ^ ιIl Ol ". Φ O N ι(l ιn B tf ιn n Φ Φ ^ B ^ ln ln "^ ιn ln M ^^ n N d o o o n »r ln ln ln ln π Φ ω ιΛ ω ln v ι^ l ι o^ "^ "^n(^,1 N ( (^,) (. o o » ιι^ Φ ^ B Φ Φ co co co ro ro ro m fo ro co co co ro co co co co co co co co co co co co co ro ro ro co co co ro co co oo co co co io co ro co co co r^ in co H CM o r- co o o o H H r- ii o ιn ι <. "p σl ( ιn

VO VD I- CM H H CM O Cn o CM CM H H rO H O cn oO O CM CM CM Cn r- i-- vD r~ vo oo ∞ r^ ι-- vD cn cn cn cD r- vo ιn oo cn o cM cM iD ro cM in co co ι i" CM CM H co cM ro ro co CM CM CM CM CM CM CM CM H CM CM CM CM CM CM CM CM H H CM CM CM CM H H H

d d ^l N N N N <^l N ιη M (η ιη ιΛ 1» ^■^^l 1J <f "p 1f ^ » ln ι l ι ιn ln ln Φ Φ ^ ^ ^ ^ ^ ^ ^ B O O B Φ β B lIl Ol ι]^ o^ ιJl (I l^ o o

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H Cl CM

^^l *^, ^ τ ^^l ^^, ^ ^^, ^^, ^^, v ^' i. ιι^, '3^, ^^, ^ ^^, ι. 9 ^ ^^, ^^, ^^, ^^, ^^, s^, ^^, ^ ^^| ^^| ^^| fl' ^^, ^' ^' v ^^, fl^, fl^, ^ ^ n^, n^ι *j 'j ^^, 'a' *ι^, 'j '. *ι ι. 'j ']^, v *a^, s^, v ^^, v v ιj υυooυooooυoυυυoooυoυυoυυυoυυoυυoooυυυυυυoooυυυoυoooυυoooooooooo

Z Z Hl lj J rJ Hl r'l J W W W W W P-' e-l Λ Λ Λ Λ Ol Λ lJ J Hl ^

CΛ CΛ CΛ rt rt rt rt rt rt rt < rH >H H < CΛ I« CΛ CΛ CΛ OT CΛ CΛ rt rt rt rt rt rt rt B X X B a X X >H _rH < >H H < < >H >ι < < > > > > > j j j j j < < «C < ; rt; (i; > > > > > > h tH r H h tι H J J J iH ₍j Hi J j j j j Hi Hi J Hi ιi J > > > > > < <

H CM H CM H CM H CM H CM H CM H CM

OQQ < moo < m rt m QQ tt moo < moo tt m o α w N tt mooα tt moo rt oozzoooυoozoooozoυooooozoooooozoυoυoυzoooυυoozzυυoυoυυzυυoυυυzυ O H CM CO o o o o CM CM CM CM CM CM CM CM 2∑∑∑ oooo

υoozυooυυozzυυoυυυozoooυυυz oooυooozzoυooooozoυooϋoooooozooooocΛO ro -«δ! C -S ^β __8

CΛ

H (M N Φ l d » θ σi Φ "K. ITl N Φ cθ H ii co [o co r- <n σι vo m ' '-^| co m cM io cM r- o o σi co cn co cn co o r- CM r- oo vo ιn cM m cΛ ι-- cD oo H co co H ro ro ιn CJ cn o co cM H cn r- ιι r~ oo ' io ιn cn co m <n r- cM ro H θ ιn i' m oo r- cΛ ι— r- H t i ιn o σι m oo o c- H CM T H CO O CO OO Γ^ O I-- ro oo r— ^, r- r~ r- cn co oo

PM _ffi O ι*. o ro (^^ o tt w (^ι N ^ ^Jl ιo ^ ιi^ ιπ ^ N (^ ^ ^ ι ιΛ ^ O N l*^ B N B - N « O ^ B d Φ ". 1- ιO ( * ιn ^ ιn Φ d (Λ

_{O O O O O O O O O O O O}O_OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO oooooooooo

H H H H H H H H H H f^ ιιl ιn ^ _d ^- ι^,l » d o o r^ d lJl O lJl ι^ B ι>) d r- O Φ '. d v » B r• O ln ^' ιIl ιfl d m B Φ B fl ln d β O d m ^ l Φ B ι! <ι^| ln N O l _d O ^ N Φ αι ω ^ Λ o ιn ^ι n Φ ιO ι_. c^ι ιn 9l "r Φ <Λ ^ o w o^ ^ ι^o ιι^ o H ι^,l »o ^l ffl ^ϊι fl <. ^ « ι»l ιn Φ N ι ω αl ln ffl ln o m ιn ln Φ m n B n n d d ιη β •» <)l B m -l o nln N ιo Φι ^1 ^ d ιn ιn Φ «. c)l ιn ι^l ln ιn n d ^ ι^,1 σι ι o » d d B ι^,l l Φ n O H ιn ^ (^,) cD in co io co co cD co m in r-- co r~ r— o. o cM θ r- t~ oo σ. ιo r- r- ι— oo n o oo t— vo in OO OPl O O OO C- r^ VD O O CM CO O O O H H CM H CM CO m m m i li VD

H H H H CM CM CM H H H H H H H H H H CM H H H H H H CM CM H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM

CM ro ro oo σι io cn m CM r- o r— cn r~

00 H CM VO d r- ιn « ιo ιn h h σι co co co ro co -r

"-τ^ι ιn vo ln B B ιo rι ln d « N Φ ιfl B (. O B l . o ^•l. N r" n cM CM i" CM CM H θ co ^, co ιn o cn oo oo cfι in o σι co co ιn ιn ι^, ι^, vo ιn ιn ι^| ι^| ιn r-- vo oo r-- co cM H o o o cM O CM CM CM CO rO rO CM 1< CM 1i r C H H CM CM O O O I

o o o d d d d d d d d ^l N N N M ι l N n ι^»ι n π n ι^») ι^,l "- " 1. ^ "l' » <. 1^' V ln lll ln ιn ln ln ιn ιn Φ Φ Φ ^ ^ ^• ^ ^ r• r•

CM CM CM CM CM CM CM CM CM CM CM CM CM CM Cl CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O

< ^ z z z z z z z Z D S D D D D D D θ θ θ θ θ θ θ n « n ι n n B i B iH λ i- ιiι ι iiι iiι iH iι; κ D; ϊ ιι; ιι; βi ιι; ιι; ιι; ιι; ιιi H H EH Eι H t< h r<

H3 H. O CΛ CΛ CΛ CΛ M M ω C-i ω ω ω ω X 0S X 0S C-: (-J Cli H >4 < H < H >H < >H CΛ CΛ Λ

< < < ^(]; < < < < i ι1 ι; ^ ιJ > _lJ ^ ^|l< h h h b O< h ri μi ^ ^ ^ _l1 > ι j < < < 4 < < < < H H H H Eι H h H h h h 2 _l 2 22 _: -; 2

H CM H CM H CM H CM H CM oomz <oooomooaoozz fooo mooaooozo ttoo mo oo aoz totoo mo oooaoω Nzz totooomoooQQoz <ooooooaoaowowoNoXoz <oooomoowoωo

zooooυoozoooooυzoooυυoozoooυυoozzoooυooυoυoozυooooozooooυυzoυoz

m H CO

"» co m oo oo H co i¹ in co * in in in in ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

_> _> 0 -. in c CO O -Λ c-Λn ι_θ> HH o cn m ιι σ. σ. ro ιn r M*- ιnn cΦD lⁱ H UO H CM OO CM OO H » ιn » φ ^ c_ m ^ ln ffl ln - O ι . H O - « N ι^,l ln ιn (^,) fl « » ιn ^ β (β » ^ r• β -ι o o ^ -J ^ σl oβ ^βι o H CM Co cM CM co ι ιn co τ co ro M CM CM C CM C l CM rO C C O CM r r r r rO ro o rj ^ rn ro r cYl rj r ro n o iη -l o -l oo n o o o d cn ro

-l O O ln ^ m N m d O lIι n * H d O (Λ Φ H O Φ ^ m ln v σl O d m o o^ ι l l CIι N B O Φ Ol N r• Φ ι^,) r• al r^■ ιn Φ lIl Φ Φ O v ιn β ln o ι^,l ^ B Φ Φ 9 0 l B N ι») lΛ o o ι^,) B O r• <^,^ ln o N fl M d N ^ O N d fl ιn Φ o v d m ∞ n ι . B π^ ι^ (Il <- O ln o ιJl ^ ιι n ^^■ (ι r• ( B d ^ o n * B » ^ d N d M N ι O O N Φ d H (n o n ^ l0 Φ -) ^ ln -l n '. d (tι Φ -l O Φ ^" O ^ ^ι^, •^^l "^ ι»l ^ (Iι β n N ( l Φ l- d ( d ^ι c co co c ιn ιn ιn r-- CM M C ιi H θ θ ro i' i c in vo co ι^ f M c ι^, C H H θ H rθ '»' '^ ro ι ιn 'r cD 'iι co co ιn ιn ιn cD CD VD VD "!r ' ^

00 CO 00 CO 00 CO co co cn <n <n <n cΛ cn <n o o o o o o o θ H H H H H H H H H CM CM CM CM CM CM CM CM cM CM cM CM co co co co co co ro ι ι ιι ι^| i' i' i' in ιn ιn ιn vD CM CM CM CM CM CM cM CM CM CM CM CM CM CM CM co co co co co co co co co co co co ro ro ro ro co co co co co co co co co ro co co co co co co co co co υoooυυooooυooooooooooooooooooooooooυooooooooυυooυoυoooooooooooυ

M₍-qw-ιω₁jωjω,-qω_1-3ω,-qw,-qχioxsxxixϊJxBxEoaHωDDωDωDωDωDωDωDω CΛ Λ CΛ CΛ CΛ tΛ CΛ CO W pS pG X αϊ β. X

X X X X X X X X X X X X X X X x Ά & α; c- i_ [_ (_ ι_ α; ιJ HH HH HH ω

H H H H H H H H H H tl tl h H tl J lj Hl Hl lj Hl lJ J J J J J J J HU J EH EH EI H EI E* 0Lι 0Lι (-ι C-ι C- Cι< C-ι O O O O 2

H CM H H CM H CM H CM H CM tt mooo tt moo ft m Q Q rt m o Q ω N m Q α ω ω tNi x zooooooozoooooυ zoυoυυυυ ooooooυzz tυto O O O O O O O O O rt moo < moo < oυoυoυzoooooozoooz NN fln «« ιmn Φ rr•• B 05^^ o0 dd ^ιι nn "«. llnrl B 0l O (^ι ( "» ιfl ^ B lΛ oo oo oo oo oo oo oo oo H H d H HH Hd HH rt H ^ι ι l^l N (. ^^ι ι^l !^l (^ι cι CMO CO rO CO CO CO CO CO CO C^ CM CM CM CM CM CM C^ ^■ -^• -^• CM CM CM CM CM CM CM CM CM CM CM CM

oooooooooooooooooooooooooooo rtrtrtrtrtrtrtrtrtrtrtrtrt rtrtrtrtrtrtrt rt rtrtrtrtrtrtrt

TaWe'4

ATOM 2330 CA MET C 436 9.467 39.746 42.053 1.00 57.85 c

ATOM 2331 C MET C 436 10.171 41.077 41.781 1.00 57.97 C

ATOM 2332 0 MET C 436 11.366 41.104 41.499 1.00 57.90 0

ATOM 2333 CB MET C 436 9.073 39.086 40.716 1.00 60.24 c

ATOM 2334 CG MET C 436 10.117 38.170 40.061 1.00 62.63 c

ATOM 2335 SD MET C 436 11.294 38.958 38.921 1.00 66.70 S

ATOM 2336 CE MET C 436 10.350 39.014 37.425 1.00 65.33 c

ATOM 2337 N ASP C 437 9.435 42.179 41.884 1.00 58.78 N

ATOM 2338 CA ASP C 437 10.000 43.494 41.596 1.00 59.01 c

ATOM 2339 C ASP c 437 10.399 44.398 42.766 1.00 58.17 c

ATOM 2340 o ASP c 437 11.122 45.370 42.564 1.00 58.63 o

ATOM 2341 CB ASP c 437 9.056 44.253 40.652 1.00 59.84 c

ATOM 2342 CG ASP c 437 7.672 44.451 41.239 1.00 61.99 c

ATOM 2343 ODl ASP c 437 7.187 43.548 41.953 1.00 62.11 o

ATOM 2344 OD2 ASP c 437 7.058 45.507 40.971 1.00 63.72 o

ATOM 2345 N VAL c 438 9.957 44.100 43.982 1.00 57.08 N

ATOM 2346 CA VAL c 438 10.333 44.949 45.113 1.00 57.03 C

ATOM 2347 C VAL c 438 10.929 44.203 46.306 1.00 56.72 C

ATOM 2348 o VAL c 438 11.658 44.789 47.110 1.00 56.31 o

ATOM 2349 CB VAL c 438 9.134 45.800 45.619 1.00 57.87 c

ATOM 2350 CGI VAL c 438 8.678 46.761 44.529 1.00 58.76 c

ATOM 2351 CG2 VAL c 438 7.991 44.898 46.059 1.00 57.18 c

ATOM 2352 N LEU c 439 10.625 42.916 46.425 1.00 55.85 N

ATOM 2353 CA LEU c 439 11.146 42.132 47.534 1.00 55.27 c

ATOM 2354 C LEU c 439 12.559 41.640 47.258 1.00 54.28 c

ATOM 2355 o Lεu c 439 12.969 41.499 46.104 1.00 53.11 o

ATOM 2356 CB LEU c 439 10.243 40.924 47.816 1.00 55.76 c

ATOM 2357 CG LEU c 439 8.888 41.175 48.477 1.00 56.88 c

ATOM 2358 CDl LEU c 439 8.011 42.009 47.559 1.00 59.05 c

ATOM 2359 CD2 LEU c 439 8.218 39.851 48.783 1.00 56.52 c

ATOM 2360 N PRO c 440 13.333 41.387 48.324 1.00 53.74 N

ATOM 2361 CA PRO c 440 14.699 40.902 48.121 1.00 52.02 C

ATOM 2362 C PRO c 440 14.682 39.494 47.528 1.00 50.04 C

ATOM 2363 o PRO c 440 13.806 38.682 47.833 1.00 48.79 o

ATOM 2364 CB PRO c 440 15.299 40.948 49.529 1.00 52.43 C

ATOM 2365 CG PRO c 440 14.116 40.725 50.414 1.00 52.90 c

ATOM 2366 CD PRO c 440 13.050 41.583 49.759 1.00 53.29 c

ATOM 2367 N SER c 441 15.653 39.234 46.665 1.00 48.29 N

ATOM 2368 CA sεR c 441 15.818 37.957 45.984 1.00 46.16 c

ATOM 2369 C sεR c 441 15.447 36.715 46.802 1.00 44.55 c

ATOM 2370 o sεR c 441 14.661 35.887 46.361 1.00 41.81 o

ATOM 2371 CB sεR c 441 17.267 37.852 45.500 1.00 45.60 c

ATOM 2372 OG SER c 441 17.634 36.516 45.230 1.00 52.84 o

ATOM 2373 N HIS c 442 16.006 36.587 47.998 1.00 46.27 N

ATOM 2374 CA HIS c 442 15.732 35.417 48.823 1.00 47.87 C

ATOM 2375 C HIS c 442 14.251 35.235 49.123 1.00 47.05 c

ATOM 2376 o HIS c 442 13.819 34.172 49.573 1.00 46.64 o

ATOM 2377 CB HIS c 442 16.550 35.478 50.125 1.00 49.97 C

ATOM 2378 CG HIS c 442 16.105 36.539 51.085 1.00 51.99 C

ATOM 2379 ND1 HIS c 442 15.059 36.357 51.966 1.00 52.74 N

ATOM 2380 CD2 HIS c 442 16.582 37.786 51.318 1.00 51.71 C

ATOM 2381 CEl HIS c 442 14.913 37.446 52.702 1.00 52.93 C

ATOM 2382 NE2 HIS c 442 15.824 38.327 52.329 1.00 52.63 N

ATOM 2383 N CYS c 443 13.467 36.270 48.861 1.00 46.79 N

ATOM 2384 CA CYS c 443 12.042 36.181 49.113 1.00 47.55 C

ATOM 2385 C CYS c 443 11.280 35.549 47.957 1.00 44.52 C

ATOM 2386 o CYS c 443 10.168 35.066 48.156 1.00 44.07 o

ATOM 2387 CB CYS c 443 11.449 37.564 49.396 1.00 52.06 C

ATOM 2388 SG CYS c 443 11.991 38.314 50.959 1.00 59.63 S

ATOM 2389 N TRP c 444 11.872 35.526 46.762 1.00 41.20 N

ATOM 2390 CA TRP c 444 11.158 34.974 45.611 1.00 38.57 C

ATOM 2391 C TRP c 444 11.831 34.011 44.615 1.00 36.90 C

ATOM 2392 o TRP c 444 11.136 33.181 44.039 1.00 34.96 o ru 4

ATOM 2393 CB TRP C 444 10.539 36.129 44.812 1.00 35.62 c

ATOM 2394 CG TRP C 444 11.547 37.163 44.372 1.00 32.01 C

ATOM 2395 CDl TRP C 444 11.911 38.298 45.043 1.00 32.10 C

ATOM 2396 CD2 TRP C 444 12.341 37.131 43.180 1.00 28.95 C

ATOM 2397 NEl TRP C 444 12.887 38.973 44.343 1.00 27.58 N

ATOM 2398 CE2 TRP C 444 13.171 38.279 43.199 1.00 26.83 C

ATOM 2399 CE3 TRP C 444 12.434 36.245 42.098 1.00 28.17 C

ATOM 2400 CZ2 TRP C 444 14.082 38.560 42.182 1.00 25.62 C

ATOM 2401 CZ3 TRP C 444 13.344 36.523 41.083 1.00 26.33 C

ATOM 2402 CH2 TRP C 444 14.157 37.672 41.134 1.00 28.83 c

ATOM 2403 N ILE C 445 13.143 34.110 44.388 1.00 36.37 N

ATOM 2404 CA ILE C 445 13.792 33.226 43.408 1.00 37.21 c

ATOM 2405 C ILE C 445 13.515 31.735 43.484 1.00 36.05 C

ATOM 2406 o ILE C 445 13.457 31.075 42.449 1.00 35.39 o

ATOM 2407 CB ILE C 445 15.343 33.377 43.367 1.00 40.95 C

ATOM 2408 CGI ILE C 445 15.898 33.609 44.772 1.00 41.41 C

ATOM 2409 CG2 ILE C 445 15.735 34.437 42.348 1.00 41.56 C

ATOM 2410 CDl ILE C 445 15.849 32.377 45.652 1.00 40.58 c

ATOM 2411 N SER C 446 13.359 31.194 44.686 1.00 35.89 N

ATOM 2412 CA SER C 446 13.104 29.766 44.828 1.00 36.80 C

ATOM 2413 C SER C 446 11.899 29.348 43.999 1.00 36.19 C

ATOM 2414 o SER C 446 12.014 28.507 43.105 1.00 37.02 o

ATOM 2415 CB SER c 446 12.870 29.404 46.297 1.00 39.47 C

ATOM 2416 OG SER c 446 12.486 28.044 46.444 1.00 37.74 o

ATOM 2417 N GLU c 447 10.744 29.933 44.292 1.00 33.96 N

ATOM 2418 CA GLU c 447 9.532 29.606 43.551 1.00 32.24 C

ATOM 2419 C GLU c 447 9.635 30.046 42.080 1.00 29.53 C

ATOM 2420 o GLU c 447 9.181 29.339 41.183 1.00 28.78 o

ATOM 2421 CB GLU c 447 8.309 30.266 44.211 1.00 34.77 C

ATOM 2422 CG GLU c 447 6.975 29.899 43.567 1.00 39.16 C

ATOM 2423 CD GLU c 447 6.655 28.416 43.690 1.00 42.43 C

ATOM 2424 OEl GLU c 447 5.783 27.919 42.945 1.00 43.28 o

ATOM 2425 OE2 GLU c 447 7.275 27.744 44.541 1.00 46.08 o

ATOM 2426 N MET c 448 10.240 31.201 41.825 1.00 27.08 N

ATOM 2427 CA MET c 448 10.352 31.670 40.449 1.00 28.04 C

ATOM 2428 C MET c 448 11.130 30.707 39.567 1.00 27.17 C

ATOM 2429 o MET c 448 10.719 30.399 38.446 1.00 26.96 o

ATOM 2430 CB MET c 448 11.009 33.047 40.381 1.00 28.47 C

ATOM 2431 CG MET c 448 10.954 33.671 38.987 1.00 33.18 c

ATOM 2432 SD MET c 448 9.381 34.531 38.559 1.00 40.53 s

ATOM 2433 CE MET c 448 8.128 33.296 38.951 1.00 38.78 c

ATOM 2434 N VAL c 449 12.264 30.248 40.073 1.00 25.81 N

ATOM 2435 CA VAL c 449 13.104 29.322 39.339 1.00 26.02 C

ATOM 2436 C VAL c 449 12.311 28.054 39.050 1.00 26.19 C

ATOM 2437 o VAL c 449 12.356 27.520 37.936 1.00 27.20 o

ATOM 2438 CB VAL c 449 14.398 29.025 40.150 1.00 28.96 C

ATOM 2439 CGI VAL c 449 14.830 27.598 39.989 1.00 30.72 C

ATOM 2440 CG2 VAL c 449 15.506 29.964 39.682 1.00 28.33 C

ATOM 2441 N VAL c 450 11.560 27.588 40.041 1.00 24.17 N

ATOM 2442 CA VAL c 450 10.753 26.391 39.861 1.00 24.70 C

ATOM 2443 C VAL c 450 9.697 26.627 38.788 1.00 24.32 C

ATOM 2444 o VAL c 450 9.442 25.756 37.946 1.00 24.90 o

ATOM 2445 CB VAL c 450 10.056 25.976 41.182 1.00 26.76 C

ATOM 2446 CGI VAL c 450 8.980 24.935 40.914 1.00 24.89 C

ATOM 2447 CG2 VAL c 450 11.077 25.404 42.141 1.00 25.53 C

ATOM 2448 N GLN c 451 9.094 27.809 38.802 1.00 23.10 N

ATOM 2449 CA GLN c 451 8.063 28.114 37.819 1.00 21.98 C

ATOM 2450 C GLN c 451 8.625 28.401 36.437 1.00 19.81 C

ATOM 2451 o GLN c 451 7.993 28.077 35.437 1.00 21.40 o

ATOM 2452 CB GLN c 451 7.196 29.283 38.294 1.00 22.86 C

ATOM 2453 CG GLN c 451 6.279 28.940 39.480 1.00 24.71 C

ATOM 2454 CD GLN c 451 5.431 27.670 39.270 1.00 25.91 C

ATOM 2455 OEl GLN c 451 5.034 27.346 38.152 1.00 24.23 o υυυozoυ

O CM H r- H m c CΛ CM CM CΛ lⁱ lⁱ OO <l^l Ol r^■ IIl □ 0

OOOO _ O_ O_ O_ O_ O_ O_ O_ O_ O_ O_ O_ 000000000000000000 oooooo _o_o_o_o_oO

OOOOOOOOOOOOOOOOOO OOOOOOOOOOOO oooooooooooooo-oOoOoOoOoOoOoOoOoOoOoOoOoOoOoOoOoOoOo rH r rH ri rH ι ιn "r ^ lfl ιn "l^l O ". Λ ^ ιll d n O O H fO ιι ^ι ι() O t^ (^l ^ ^ ffl N m o ι>l ιJι ^ B W » d « ^ <Il N ". ιn m (^ι Φ l d » ^ ιJl _) « B O ^l B β ^ O N ^ ln c. « ιrι d "ι^l « H Ol O O B l N n ^• ^ ^ ^ (. m d fl 0 ^ ^r O fl ι^,l tM ιn w β d β ^ N O B D Λ O> (<l r) 0 ll (^ι o n N ^ d d σl s^ι B l. O d (^,l B ln Φ Ol ln » B r• Ol oo o d B O d o ^■■ "^ r• n n ι^,^ t" O ιn (ι ol Cl C^ι π M ιn ^ B

O lft ^ o1 ιΛ ln Φ v ιn "f 1» ιo Λ ln « v π ^ι ιn ^ ^r » ^ι d o ol N O Oι ιJ1 ^ o O B d O Ol 5ι B d d O ι)l β Φ lll o d d ^ ιn v ι^,l Φ « « ιft ιn 9 n 'T' co co co co ro ro ro co co c co ro io co ro ro co ro c co co co co co co cM co co co cg cM CM ro ro cg co co cM CM CM ro co co cM C^ ln ^ N Ol ι- ω c^| 1. (^l lη n N O N » N O^ ιη o n ffl -l -l o o o -^ ωcJ n B B ^l N ^ Φ ιIι B m « ". ι^,l o Φ ι^,l « o σι 1. o\ o rι O O B <ι^, ι-• Φ O d O d < ιn "l^| oι ιrl « ιn c ^l "l' ι!l O <. N (^ Φ o ι ιn ιn o n d d ^ N lΛ N v <Iι m O (M ι>l « ιn ιIl ιn o ol B B r" Ol O n ft B n ι»ι o O "^ β ιΛ O « o n ιn Jl ^ ^Iι (. d ^• l/l l- 0 ^ π -l Φ -) -l B O ^ Φ ^ r• N ^l d d O ιn ro M l" c "^ « Φ -l O ^ Φ ^■ Φ Φ ^ ^ O N M ^ ln ιn w « ιη Λ v ln >l' '( (^ ^ι w ^ B -> Φ ^> "^ Φ B <. ι ^l d d d O o^ ι<l M ι>1 ^ N « ^ ln ". '^ r^■ B ι») (^l H O

CM CM CM CM CM CO CO CO CO CM CM CM CM CM CM CM CSI CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ m

-Λ cn cM ro H rM O CM CM cn cΛ in vo cn H H c o r~ cn 'ii H r^ o r r^ c co cM cθ H H n 'r θ ιn vD r* o _i H i^| oo H c~ D σ. c o o H co r-' Cr> o r-- ιn r-- vD i H H ro o ro cM O r- vo co oo r- in ii cM O < H cn ^ι cθ 'r t~ <n ιn ιn ιn cM H <n co co ' θ co cn m ι^ι co ιn o oo o r~ co o vo oo oo H θ ro rθ H θo ro cn ιn co oo ι^ι vo cM r ιn H oo ii oo oo io ' r- oo H in ro i' H 'r CM σι ιn o oo ιn ιn ιn co cM H Vθ cM CM ι^, c H θ r~ ro co ιo crι r~ co ro cD σ. 'r co o cM r-- o vD oθ H θ co o oθ H co o cM o oo cΛ m CΛ o o o d d N O d d O O N N 5ι M~ Φ -) ιn » M" B M" l051000 d N N d αi B

H CM CM CM CM CM CM CM CM co ro co co ro co ' 'r ι' 'r ι^, 'r ^, '-' in - ιn ιn ιn ιn co ιo vo vo vo vo vo co r-- r-- t~ t-^» t-- r^ ιn ιn ιn ιn _o ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn _θ ιn ιn _o ιn ιn ιn ιn ιn ιθ ιn ιn ιn ιn ιn ιn ιn ιn ιn _^

<^*- ^|ⁱ ^5* ^* ^J* ^* ^1* ^3* ^3* ^3* ^* ^3* ^1* ^^ ^3* ^* ^1* ^* **»T* ^* ^3* ^ ^3* ^* ^* ^* ^* "-β* ^* ^J* ^1* "3* ^1* ^3* ^tf ^3* ^^ ^* ^3* ^* ^3* ^3* ^3* ^* ^* ^* ^3* ^* ^3^ *^ϊ* ^^ ''■3' ^1* O* ^3* ^* ^* ^3* ^* ^3* ^1* '■-' ^* o υ υ υ υ υ υ υ υ o υυ υ υυo o υoυυo υυ υ o o υ o o o o υoϋo o o o oooooooo o oo υo o oϋ o oo υ o υ o o

Z D D O D D D D D βi lli «. _i (. p. ⁽. llι 0ι Pι Mlι Mlι K p! « |, pi (J D D D S D D D D pύ Oj Cfi βl Oύ OS l-J O-i C-i Cii Oj I-i Cii i CLi D D D D D D D D D O O

,j w w ω ω ω ω ω ω w w ω ω ω ω _. w co Qc w Λ ω w ω ω w ω ww w w w w w w x x a x x x c Λ C Λ Λ o -o u ω c-i ω E-i ixi E-i E-i ω c-i c-i

O π. l-l Hq H^ Hl H3 H5 H3 -0 W W -Λ -0 rt rt rt rt rt rt rt rt -Λ IΛ CΛ Hl H3 Hj Hq H Hl H. H; H H EH EH fH ^ iH Xl rtK lSK fll -lK lH j Hl J Hl iH j J lJ lH rl

CM H CM H CM H CM H CM H CM H CM ω a, m o a o rt m o tt m o α α ft mo cα o Q Q < m tt z zooooo υυzoυoυo z oυooo o ozoooooz So o υ υ υ υ υ o o υ o υ z υ o oυmυooaoozoooomoooαυαzo tto φ B ^βl O d ι n « ιn Φ B Ot o N n « ιn Φ ^■ B lλ O d N ι. « ιn l- B l o d N n ')^| ιn Φ l O d N ι . « ιn Φ r' oι o d N fl « ιfl Φ B -^ ιn ln -^ Φ Φ Φ Φ Φ ^ ^ ^ ^ ^ ^ ω ω B CO B Ot) a! 00 _) α) ιI m m σι - (^ _ o _ lJ o o o o o o o o o o H d H H H •^ H ^ ι. ^ ^ * ^ ^ ιr 9 ^ ^ "i^, ^ ^ fl ^ ^ v ^ ^ fl ii' fl ^ v ^ ^ * 9 ι ^ ^ 'i^, "r ^ ιι^, ^ "i^, v ' ^ iι^, v ^ ιn ιn ι_ ιn ιi ιJi ι ιn ιn ιθ ι ιπ ιn ι ιθ ιπ ιn ιπ -)

00 rH CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM W VO Σ Σ ΣΣΣΣ Σ

© o o o o o o ooo o o o oo o o o o o ooo o o ooo

S t3t ft ft tt < < < K < ft ft < ft ft <

Ψubte4

ATOM 2519 0 LEU C 460 9.204 21.730 22.697 1.00 32.84 o

ATOM 2520 CB LEU C 460 10.691 21.921 25.700 1.00 29.64 C

ATOM 2521 CG LEU C 460 11.838 21.136 25.083 1.00 28.50 c

ATOM 2522 CDl LEU C 460 12.846 22.088 24.450 1.00 24.94 C

ATOM 2523 CD2 LEU C 460 12.495 20.312 26.177 1.00 28.74 C

ATOM 2524 N ASP c 461 7.906 21.315 24.480 1.00 31.68 N

ATOM 2525 CA ASP c 461 6.988 20.445 23.746 1.00 33.28 C

ATOM 2526 C ASP c 461 6.234 21.096 22.581 1.00 31.27 C TOM 2527 o ASP c 461 5.533 20.412 21.834 1.00 30.90 o

ATOM 2528 CB ASP C 461 5.974 19.822 24.708 1.00 38.72 c

ATOM 2529 CG ASP C 461 6.624 18.885 25.705 1.00 46.26 C

ATOM 2530 ODl ASP C 461 7.253 19.374 26.674 1.00 48.70 o

ATOM 2531 OD2 ASP c 461 6.521 17.653 25.510 1.00 50.00 o

ATOM 2532 N LYS c 462 6.359 22.408 22.425 1.00 27.57 N

ATOM 2533 CA LYS c 462 5.680 23.080 21.327 1.00 25.35 C

ATOM 2534 C LYS c 462 6.564 23.086 20.079 1.00 23.43 C

ATOM 2535 o LYS c 462 6.146 23.532 19.019 1.00 24.64 o

ATOM 2536 CB LYS c 462 5.324 24.518 21.716 1.00 24.71 C

ATOM 2537 CG LYS c 462 4.388 24.630 22.919 1.00 25.36 c

ATOM 2538 CD LYS c 462 3.081 23.877 22.675 1.00 29.01 c

ATOM 2539 CE LYS c 462 2.079 24.115 23.800 1.00 31.24 c

ATOM 2540 NZ LYS c 462 2.665 23.788 25.129 1.00 34.34 N

ATOM 2541 N PHE c 463 7.781 22.580 20.214 1.00 23.53 N

ATOM 2542 CA PHE c 463 8.726 22.543 19.101 1.00 25.78 c

ATOM 2543 C PHE c 463 9.330 21.166 18.891 1.00 26.15 C

ATOM 2544 o PHε c 463 9.116 20.259 19.690 1.00 22.61 o

ATOM 2545 CB PHE c 463 9.871 23.544 19.334 1.00 25.16 C

ATOM 2546 CG PHE c 463 9.401 24.955 19.555 1.00 25.81 C

ATOM 2547 CDl PHE c 463 9.080 25.403 20.834 1.00 25.56 C

ATOM 2548 CD2 PHE c 463 9.218 25.813 18.479 1.00 21.79 c

ATOM 2549 CEl PHE c 463 8.581 26.681 21.037 1.00 21.95 c

ATOM 2550 cε2 PHE c 463 8.719 27.095 18.671 1.00 23.55 c

ATOM 2551 CZ PHE c 463 8.399 27.527 19.955 1.00 25.05 c

ATOM 2552 N SER c 464 10.082 21.030 17.801 1.00 28.14 N

ATOM 2553 CA SER c 464 10.765 19.791 17.481 1.00 32.33 c

ATOM 2554 C SER c 464 12.166 20.179 17.031 1.00 32.53 c

ATOM 2555 o SER c 464 12.357 21.206 16.388 1.00 34.11 o

ATOM 2556 CB SER c 464 10.025 19.021 16.377 1.00 33.88 C

ATOM 2557 OG SER c 464 10.234 19.586 15.099 1.00 37.24 o

ATOM 2558 N ASN c 465 13.151 19.364 17.388 1.00 35.11 N

ATOM 2559 CA ASN c 465 14.531 19.654 17.041 1.00 36.23 C

ATOM 2560 C ASN c 465 14.801 19.559 15.541 1.00 38.36 C

ATOM 2561 o ASN c 465 14.064 18.907 14.798 1.00 35.10 o

ATOM 2562 CB ASN c 465 15.469 18.716 17.797 1.00 36.73 C

ATOM 2563 CG ASN c 465 16.803 19.363 18.112 1.00 38.14 C

ATOM 2564 ODl ASN c 465 17.235 20.283 17.424 1.00 38.06 o

ATOM 2565 ND2 ASN c 465 17.466 18.876 19.151 1.00 39.58 N

ATOM 2566 N ILE c 466 15.868 20.225 15.111 1.00 41.35 N

ATOM 2567 CA ILE c 466 16.273 20.254 13.711 1.00 45.74 C

ATOM 2568 C ILE c 466 17.754 19.893 13.603 1.00 49.28 c

ATOM 2569 o ILE c 466 18.561 20.290 14.449 1.00 49.27 o

ATOM 2570 CB ILE c 466 16.052 21.655 13.114 1.00 45.87 c

ATOM 2571 CGI ILE c 466 14.573 22.030 13.223 1.00 46.31 c

ATOM 2572 CG2 ILE c 466 16.517 21.688 11.668 1.00 46.14 c

ATOM 2573 CDl ILE c 466 14.243 23.442 12.767 1.00 46.65 c

ATOM 2574 N SER c 467 18.108 19.154 12.555 1.00 51.80 N

ATOM 2575 CA SER c 467 19.492 18.723 12.354 1.00 55.48 C

ATOM 2576 C SER c 467 20.470 19.880 12.114 1.00 56.29 C

ATOM 2577 o SER c 467 21.443 20.044 12.856 1.00 57.94 o

ATOM 2578 CB SER c 467 19.561 17.732 11.188 1.00 56.27 c

ATOM 2579 OG SER c 467 20.812 17.065 11.150 1.00 59.43 o

ATOM 2580 N GLU c 468 20.217 20.676 11.078 1.00 56.47 N

ATOM 2581 CA GLU c 468 21.085 21.810 10.766 1.00 56.36 C Tame'4 ^•

ATOM 2582 C GLU C 468 20.504 23.113 11.309 1.00 54.13 C

ATOM 2583 o GLU C 468 19.343 23.432 11.055 1.00 55.55 o

ATOM 2584 CB GLU c 468 21.257 21.951 9.253 1.00 58.77 c

ATOM 2585 CG GLU C 468 21.898 20.764 8.562 1.00 63.85 c

ATOM 2586 CD GLU c 468 21.942 20.944 7.053 1.00 66.73 c

ATOM 2587 OEl GLU c 468 20.860 20.938 6.422 1.00 67.58 o

ATOM 2588 OE2 GLU c 468 23.055 21.102 6.500 1.00 67.99 o

ATOM 2589 N GLY c 469 21.309 23.862 12.055 1.00 50.79 N

ATOM 2590 CA GLY c 469 20.842 25.131 12.586 1.00 47.17 C

ATOM 2591 C GLY c 469 20.508 25.143 14.065 1.00 45.11 C

ATOM 2592 o GLY c 469 20.180 24.108 14.649 1.00 44.06 o

ATOM 2593 N LEU c 470 20.589 26.325 14.670 1.00 41.53 N

ATOM 2594 CA LEU c 470 20.282 26.483 16.085 1.00 39.49 C

ATOM 2595 C LEU c 470 18.775 26.660 16.302 1.00 36.77 C

ATOM 2596 o LEU c 470 18.283 27.779 16.444 1.00 38.40 o

ATOM 2597 CB LEU c 470 21.028 27.688 16.653 1.00 40.94 C

ATOM 2598 CG LEU c 470 20.817 27.897 18.152 1.00 44.12 C

ATOM 2599 CDl LEU c 470 21.261 26.630 18.898 1.00 45.02 C

ATOM 2600 CD2 LEU c 470 21.587 29.121 18.629 1.00 41.73 C

ATOM 2601 N SER c 471 18.063 25.539 16.343 1.00 31.88 N

ATOM 2602 CA SER c 471 16.620 25.505 16.525 1.00 27.37 C

ATOM 2603 C SER c 471 16.139 26.114 17.835 1.00 24.48 C

ATOM 2604 o SER c 471 16.896 26.240 18.796 1.00 24.37 o

ATOM 2605 CB SER c 471 16.130 24.055 16.462 1.00 27.40 c

ATOM 2606 OG SER c 471 16.464 23.358 17.658 1.00 23.30 o

ATOM 2607 N ASN c 472 14.864 26.480 17.874 1.00 22.24 N

ATOM 2608 CA ASN c 472 14.288 27.036 19.095 1.00 22.64 C

ATOM 2609 C ASN c 472 14.289 25.927 20.135 1.00 20.43 C

ATOM 2610 o ASN c 472 14.493 26.166 21.323 1.00 19.53 o

ATOM 2611 CB ASN c 472 12.852 27.518 18.854 1.00 20.78 C

ATOM 2612 CG ASN c 472 12.795 28.860 18.139 1.00 21.60 C

ATOM 2613 ODl ASN c 472 11.747 29.262 17.624 1.00 25.78 o

ATOM 2614 ND2 ASN c 472 13.912 29.563 18.118 1.00 21.36 N

ATOM 2615 N TYR c 473 14.062 24.705 19.674 1.00 21.65 N

ATOM 2616 CA TYR c 473 14.039 23.551 20.562 1.00 20.71 C

ATOM 2617 C TYR c 473 15.352 23.414 21.344 1.00 19.56 C

ATOM 2618 o TYR c 473 15.355 23.365 22.585 1.00 17.41 o

ATOM 2619 CB TYR c 473 13.786 22.275 19.753 1.00 22.94 c

ATOM 2620 CG TYR c 473 13.765 21.026 20.598 1.00 24.69 c

ATOM 2621 CDl TYR c 473 12.580 20.570 21.166 1.00 25.55 c

ATOM 2622 CD2 TYR c 473 14.940 20.329 20.872 1.00 25.72 c

ATOM 2623 CEl TYR c 473 12.559 19.454 21.991 1.00 27.45 c

ATOM 2624 CE2 TYR c 473 14.930 19.213 21.695 1.00 30.34 c

ATOM 2625 CZ TYR c 473 13.735 18.784 22.253 1.00 28.31 c

ATOM 2626 OH TYR c 473 13.722 17.700 23.101 1.00 34.15 o

ATOM 2627 N SER c 474 16.475 23.365 20.636 1.00 20.25 N

ATOM 2628 CA SER c 474 17.757 23.212 21.331 1.00 23.68 C

ATOM 2629 C SER c 474 18.106 24.402 22.224 1.00 22.92 C

ATOM 2630 o SER c 474 18.703 24.227 23.290 1.00 23.47 o

ATOM 2631 CB SER c 474 18.894 22.932 20.336 1.00 23.74 C

ATOM 2632 OG SER c 474 19.008 23.954 19.372 1.00 33.18 o

ATOM 2633 N ILE c 475 17.732 25.610 21.810 1.00 22.40 N

ATOM 2634 CA ILE c 475 18.004 26.785 22.638 1.00 20.76 c

ATOM 2635 C ILE c 475 17.202 26.653 23.925 1.00 21.49 c

ATOM 2636 o ILE c 475 17.721 26.876 25.025 1.00 19.81 o

ATOM 2637 CB ILE c 475 17.582 28.102 21.956 1.00 21.73 c

ATOM 2638 CGI ILE c 475 18.446 28.365 20.727 1.00 19.99 c

ATOM 2639 CG2 ILE c 475 17.707 29.265 22.940 1.00 19.73 c

ATOM 2640 CDl ILE c 475 18.116 29.694 20.032 1.00 24.22 c

ATOM 2641 N ILE c 476 15.933 26.280 23.800 1.00 21.24 N

ATOM 2642 CA ILE c 476 15.104 26.129 24.997 1.00 20.97 c

ATOM 2643 C ILE c 476 15.642 24.986 25.853 1.00 20.70 c

ATOM 2644 o ILE c 476 15.673 25.079 27.084 1.00 19.30 o Table 4

ATOM 2645 CB ILE C 476 13.619 25.815 24.654 1.00 21.79 c

ATOM 2646 CGI ILE C 476 12.958 27.026 24.002 1.00 22.13 c

ATOM 2647 CG2 ILE C 476 12.860 25.435 25.925 1.00 16.53 c

ATOM 2648 CDl ILE C 476 11.744 26.657 23.170 1.00 21.09 C

ATOM 2649 N ASP C 477 16.061 23.907 25.200 1.00 23.82 N

ATOM 2650 CA ASP C 477 16.578 22.740 25.918 1.00 25.99 C

ATOM 2651 C ASP C 477 17.739 23.163 26.820 1.00 26.65 C

ATOM 2652 o ASP c 477 17.831 22.725 27.966 1.00 27.58 o

ATOM 2653 CB ASP c 477 17.027 21.670 24.925 1.00 30.12 C

ATOM 2654 CG ASP c 477 17.187 20.295 25.568 1.00 36.38 C

ATOM 2655 ODl ASP c 477 17.789 19.407 24.919 1.00 39.97 o

ATOM 2656 OD2 ASP c 477 16.707 20.094 26.708 1.00 36.57 o

ATOM 2657 N LYS c 478 18.612 24.030 26.317 1.00 27.68 N

ATOM 2658 CA LYS c 478 19.736 24.519 27.119 1.00 29.23 C

ATOM 2659 C LYS c 478 19.227 25.353 28.300 1.00 29.75 C

ATOM 2660 o LYS c 478 19.727 25.230 29.427 1.00 31.70 o

ATOM 2661 CB LYS c 478 20.673 25.398 26.284 1.00 30.85 C

ATOM 2662 CG LYS c 478 21.161 24.782 24.983 1.00 38.41 C

ATOM 2663 CD LYS c 478 22.194 23.690 25.197 1.00 42.83 C

ATOM 2664 CE LYS c 478 22.812 23.268 23.867 1.00 46.03 C

ATOM 2665 NZ LYS c 478 23.965 22.340 24.062 1.00 50.46 N

ATOM 2666 N LEU c 479 18.244 26.213 28.053 1.00 27.40 N

ATOM 2667 CA LEU C 479 17.719 27.045 29.135 1.00 28.07 C

ATOM 2668 C Lεu c 479 17.145 26.193 30.258 1.00 24.73 C

ATOM 2669 o Lεu c 479 17.341 26.498 31.434 1.00 22.84 o

ATOM 2670 CB Lεu c 479 16.655 28.020 28.611 1.00 26.25 C

ATOM 2671 CG Lεu c 479 17.165 29.012 27.560 1.00 31.77 C

ATOM 2672 CDl LEU c 479 16.070 30.035 27.264 1.00 31.46 C

ATOM 2673 CD2 LEU c 479 18.437 29.712 28.056 1.00 29.08 C

ATOM 2674 N VAL c 480 16.449 25.121 29.889 1.00 26.01 N

ATOM 2675 CA VAL c 480 15.858 24.200 30.861 1.00 26.10 C

ATOM 2676 C VAL c 480 16.934 23.591 31.754 1.00 28.41 c

ATOM 2677 o VAL c 480 16.794 23.536 32.981 1.00 30.02 o

ATOM 2678 CB VAL c 480 15.101 23.033 30.150 1.00 27.48 C

ATOM 2679 CGI VAL c 480 14.709 21.944 31.174 1.00 22.70 C

ATOM 2680 CG2 VAL c 480 13.847 23.573 29.438 1.00 22.45 C

ATOM 2681 N ASN c 481 18.015 23.134 31.138 1.00 29.31 N

ATOM 2682 CA ASN c 481 19.091 22.523 31.904 1.00 31.74 C

ATOM 2683 C ASN c 481 19.737 23.501 32.855 1.00 32.23 C

ATOM 2684 o ASN c 481 20.096 23.137 33.968 1.00 34.43 o

ATOM 2685 CB ASN c 481 20.135 21.926 30.968 1.00 31.52 C

ATOM 2686 CG ASN c 481 19.678 20.618 30.381 1.00 36.47 C

ATOM 2687 ODl ASN c 481 19.393 19.673 31.118 1.00 37.95 o

ATOM 2688 ND2 ASN c 481 19.592 20.549 29.050 1.00 38.74 N

ATOM 2689 N ILE C 482 19.890 24.745 32.424 1.00 31.94 N

ATOM 2690 CA ILE c 482 20.473 25.739 33.296 1.00 32.92 C

ATOM 2691 C ILE c 482 19.513 26.004 34.445 1.00 33.63 C

ATOM 2692 o ILE c 482 19.916 26.019 35.612 1.00 33.56 o

ATOM 2693 CB ILE C 482 20.737 27.064 32.550 1.00 35.61 C

ATOM 2694 CGI ILE c 482 21.821 26.853 31.489 1.00 36.13 C

ATOM 2695 CG2 ILE c 482 21.172 28.145 33.544 1.00 37.84 C

ATOM 2696 CDl ILE c 482 22.014 28.027 30.560 1.00 35.81 C

ATOM 2697 N VAL c 483 18.235 26.194 34.125 1.00 33.38 N

ATOM 2698 CA VAL c 483 17.268 26.490 35.170 1.00 34.28 C

ATOM 2699 C VAL c 483 17.063 25.317 36.115 1.00 34.62 C

ATOM 2700 o VAL c 483 16.742 25.518 37.283 1.00 31.29 o

ATOM 2701 CB VAL c 483 15.911 26.951 34.586 1.00 35.64 C

ATOM 2702 CGI VAL c 483 14.940 27.255 35.710 1.00 36.63 C

ATOM 2703 CG2 VAL c 483 16.109 28.199 33.745 1.00 36.55 C

ATOM 2704 N ASP c 484 17.240 24.096 35.616 1.00 36.84 N

ATOM 2705 CA ASP c 484 17.106 22.922 36.473 1.00 39.62 C

ATOM 2706 C ASP c 484 18.272 22.892 37.450 1.00 38.62 C

ATOM 2707 o ASP c 484 18.115 22.499 38.603 1.00 39.47 o oooozooooooozooooooozoooυoozoooυoooozυυoocΛZoooooozoooυzoϋoυzυoo rt 3Ϊ δ

H Λ ιn ^ ln o »^ m o B B d O (^ι ιn ^ι "l' m (>l (n ιn co N d B (. o •» B O ι ιn (>l O ln ln ^ o N n lfl Λ Φ m ι fl N ln N O •. o cM oo ii in co co CJ B θ θ θ ιn m ι^,ι ι»ι oι θ B N θ Φ » B <ι^ι o » n d B B i^,i d i. ιn d in o iΛ r- » d ι iM iιi d oι » ιn d in π π » i" in Φ sι o oo cM in H H co m cn PM CM Γ- O CM OO O H CM CM CO VO Γ- H CM H O r ro rsi cM in oo co co oco o i' co io co σi cM H ro cn cM i' csi i' o vo oo o o cn σi co H ro in incM oo σi H H O co i' vo vo ιι ιι ιn ιn r ι ι^l ι^l ι^, ι ιι ιι ^, i' 1^ι » « <ι^ι •. "^ >» v « ^ ιnln lO ln ιn ιn ΦΦΦm Φ r■ ^ Φ Φ ^ '-• r• ^ ^ m ωo)0 !Dffl

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO r ri ri rH H H H H H H H H H co cM CΛ co o. m in vo r- co co -_' O io co co H -. cM i^ι o ιn co cD H in ιn ιn co r-- co cM CM θ co H r-- H in r-- ιn ιn oo vo ιn co cM ro co co r_ co ιn ro c CMM CM CO UO H H in O m r- OO VO CO OO H CO Ii OO rO li O OO O^ CD ιn ro ιn ιι iD ι ιι α) co o cn cM r-- H CD CM co r- o cΛ vθ H r-- ro oo ro oo ιn H CM i' r-- oo c oo θ H o —o O OO CM O OO I -0

Φ o m σ. oo o H H O H o r- r- r- oo o H ii'> OO H O O CM CM H CM Vo ⁱ _o vo r-- co vo in vD H cn o H H oo i--- r-- r- oo o o o ⁱ co ro r~ co oo r_ 00 CM 1* 1* 1" 00 O m m m ii D r— en o r— cD vo m oo on o H m oo r- oΛ O H CM co o cn H O O CΛ co co ιn vD r H ^, ιn vD r~ ιn vo ι^ι cD r-- θD θo co co cn cn cn m o θ H CM co co co co co co ro _^, ro co co co co co i i^, ro co co ro i* i^, i* i i C 1 1 1i 1 1 1^, 1 1 1 1 1^, 1 1 1 1i 1i 1i 1i 1 1^, 1 1 1 i in i in cn <n o co co r- H O. o co c NM Φ_> ^ ιΛ ^ O d O^ Ol lD 5l l -l d ^ Φ ιl σι (1 M. ιn Ol d ιn "l' Φ d m ^ d O ll ιι1 B ιΛ d d ιn d Ol <. ιJι ιJl CD r- O cM H O OD O co r- i ro r-- ^ cM H Φ o m B Λ ι π ιn ^ ^ ln ^ o Φ -l B B H ι^ (D m π lr) (η "f ιn o o τ ln d n ( .»-), ^ . ω n .. ι -n. ~ Φ — .-, Φ — H cn r- vo co m f co co cM cn oo αo φ (0 ^^, ". B H ιη ln σ>0 '^^, ιn ιn Ol ιn ^ co Φ (^ι o o Φ a) ι^,1 c^ Φ O^ ul ι (^ι Φ (l) ιn m cn m cn ιinn (rOo co um1 (co ιinn lmn H Φvo o- o co in

H H H o n rO '. ro co cM H co in vD in vD i- oo cn oo m ro ro ro cM ' CM H CM CM O O Oo oo co ι^, m m ιn ^, ιn co m m vo r- r- co cM CM H H co co ι i' CM in ιo r~ vD O

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM m cn cM cM co vo i— H oo co cD co iⁱ in oo H co r— oo cM CM O co m i— r— ro t- iⁱ co vo o in co o co co i co r-. oo -- oo oo ιn ιn r- ι <n ιn oo co i' co ιn cM H CM Cθ H CD r- co oo σ^ i "^ r-- " o cM CM co ι r- r oθ 'ii 'i" i vo H '- ι H cn ι< r-- σ. ro r-- o cM r ι co M i - θ cM H "-• oo co co io in o vo o co co oo co co -O i' CM H CM m H r- i' CO o r— r- > iⁱ vD <o vD oo cM cn in r- co co co cD CD CM O 'r 'r o r-- ' ro cD o oo vD r-- r-- o r-- iⁱ iⁱ cM O CM r- r- r- σi o m H oo -Λ ro cD H CM co r- O H O H cn in cM cn o r- in ⁱ in <n o o o H CM H CM cn cn oo c_ oo -. -. H r- _i r- iO in 1i 00 C0 C. _n O. O. Ci OT o O H O O H CM Oo oo r- r- co in r- r- CO OO CD O-l O H CM O O H H r

H H H H H CM CM CM CM CM CM CM H H H H H H H CM H H H H H CM CM CM CM CM CM CM H H H H H H H H H H H H CM CM CM CM CM CM CM CM

« '^ "^ "» ln ln ln ιn ι ιΛ ιn ιn Φ Φ Φ Φ ^ ^ ^ ^ β B B ω o⁾ B !o o ω -l - m _l ⁽Jl Ol o o oo o o o d d ι l N N ι c^ ι^,) n n co co co co co oo co co co co co oo cD co co co co co co ro co ∞ co ∞ co co co oo co ∞ co co co ∞ ∞

*. W W ^ ι]^, ^ ^ 9 ^ ^ ^ q< ^ ^ 4 ^ W *7 ^ι]< ^>]< ι3< ^ ι]< ^ ^ V ^ W V ^^, ιr φ ^^, ^^, W 4 ^ 4 ^ ^ ^ ^ φ l]i *. 1. '. '. 4> ^ qι ^ W 7 ^ ^ q< oυoooooυυϋooυυoooυυoυυoυυooooooooooooooooυoυooooooυooυoυooooooo

0, (-ι D D D D D L_⁾ D J H5 H. J _>-l H H D D D D D D D D D W Λ

CΛ Λ M ω ω W W ω W W rt rt rt rt rt rt rt H_{H H. l}J _HP _Hl _H5 _{HH HH H}3 < >H X x X X ft CΛ CΛ CΛ CΛ CΛ D D D D D Z Z Z Z

>1 1 1 l _Hl _Hl ιJ J J n θl O) [() ft < < tt tt tt ft ft < tt ⁾ i _>-l HH H. HH HH HH > > > > > > > 0000000 0000000 0 > f>t f>-3 _>< f>* J>* <> _

Hq j -l -l iJ O O O rt rt rt rt omυoopoQz <υooυmoυaoooz <υoo mυoυoααozoυoυmoυoυzo <ooυmoooα oo o H ro 1. ln ^ m o d ^ι n <^ ιn Φ ^ B O ιι M fl ιn ^ m o d c^ι ^^ 1. ln r- ω -l O d ^l (^|1 " ιn ^ ιxι ιI^ O d (^ι m 'J' ln B ιIl O

O O H H H H d d d H H N i ( N M i N N N N n n n n m n n π π ι^yι ^ ι. ^ ιι^, "f ^ « ^ 'ii^, >. ιn ιn ιn ιn ιn ιιi ιn iΛ in ιr) Φ Φ Φ Φ Φ r- r- r- r- r- r- r- r r—-- r ⁱ—- r ⁱ—- [— ^ ^ t— ^ ^ r- ι— r- i— r- r- i— r- i— I— r- c- r- r- r- i— r* r- r- c- r^

-M CM OM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CNI CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM

o 2o2o2o2 ∑oo∑ 2oo22oo22oo2 ao2o2oo2o2o2o∑ 2o2o∑oo2 ∑oo∑ ∑o∑o∑o2oo2o22oo∑ ∑o∑oo∑o∑ ∑oooooooooooooooooooooooooo

O h Ej E_ h H EH h H h h !H H H E< EH h h h Eι tH H ι tι ι H tι tι h H H H H H h E< H H E-^; h t h h h H h H h H h ^ tι h H H H EH h H ft ft ft < ft < < ft tt < < < ft < < < < < < ft < < < < < < ft tt tt ft ft < < ft < tt < tt < < < ft < < < < ft < < < < < <

υ z υ o o υ z o o o o z oo o o z o υo o z o o o ozυooo z o o o o z υ υ o ϋ z υ υ o υ z o υ oυυ o o z z oo oo o z o r- ro

C.

H cn m m oo cM CJ o n n iji 'i' PM (. t t O ooooooooooooooooooooooooooooooooooooooooooooooooooσoooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooσoooooooooooo

cM O CM

O Φ O l^l ιJl ιIl (Jl O d ιn ι<) N β 9ι ι») (^ B B O ln ^ O n r- m ιn l ιi^ ^ ι^,l ι^,) Mη d r- d d ^ d O d B ιIι ι! o o c>ι ^ - o n B 0 ^ O ( 0l (^l N V ". ^ d O ( n ιn l ln t" O ^ ( ln o n 1- "l^| c. π ω ^ c^ 01 ιfl Φ ^ w ^ ^ι B ιn ι3l (^,) ιIι ^- ^l B ln ^^ < B (Il d ιtl lΛ O ι . O d l ^ <. ^ ln β <Il B f^ » lJ^ Φ ιl) o B n N O B O ιn N ιn ^l d d ^r d d N O ^ B ^■- N Ol O B « Φ ^ (^,) β βι β o O N O (M ^ r^■ -l -l Ol o o ιIl ι ^l (^,1 n d d O O H d O O l ^ Φ r• B -ι ιIl l O ^ -) -) -) -) -) Φ Φ « "l^| c^,^ l r• ffl O σι ol O d

CM CM CM CM CM CM CM CM t CO CM CO CO CO CO CO CO CO CO CO CO CO rO CO CO lO CM CM C CM CM CM CM CM CM CM CM CM CM CM rO CM CM CM C^ m

CM 00 CΛ m θ. σ* C CO ιn ιn m m w N Ol n ιn u) ^^ c ω ln -1 ιB d 0^ t^ ιrι o d 0 ω B ln Φ <Λ Φ O ιn ". m * Φ O N lJι ιJ Φ ^ ι^,ι ol M rl B O d l vOo ec min ccMM Oo Oo Oo rr-— cocooo HH imn HH ccnn oooo ccMM θO iioo ιioo cro oo <enn rr—- r r—~ ιi^,i ι mmmn cen ι11iι11i rrrr———- H o O rM- ιnO ι-nl < ans H ccoo oooo m oo "* - c '_^ι co cM in co H CD ιn co σ ro H θ H oooo oo c ro 'τ cM θo ccoo c enn ro cM r- co in m oo co n co H r- H in o ro m oo cM in i o co o H cn in CD 1* T O co σi en co co H r- CO H in O H CM CM CD H ⁱ r- oo oo

O H H O O CM cn oo r- vo σi oo oo r- oo on io m T co ro cM H H H H H O cn cM cn oo r- r- r- in i' i' co in m ' i' in co co cM H O cM H H o o o o o o o o o

CM CM CM CM CM CM H H H H H H H H H H H H HHHHHHHHHH H

co ¹ ι^ι ι^ι ιι ι^ι ιn ιn ιn m m ιo vo vo cD CD r- ι— r- r- r— co oo oo co <x> <n cn en cn cn o o o o o H H H H H CM CM CM CM CM ro co ro co ro co co ro eo i i i iⁱ iⁱ in -0 cn cn n cn cn cn -Λ cTi σϊ cn cΛ cn cΛ cri cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn o o o o o o o o o o o o o o o o o o o σ o o o o o o o o o o o o

» "» "τ ^ ^ w 9 « « » ι» <ι -» *» "j -* *» -j v 'j *f if 'f 'f >» ^ v ι. » ιn ιn ιn ιn ιn ιn ιn ιn ^ ι ιfl ι iΛ in ιn ιfl ιn Λ o o o o o o o o o o o o o o o o o o o o o oooooo oooo o o oo o o oo o o o o ooooo o oooo ooooo o oooo X (ύ <£ & && cύ ύ ci Λ tnm mu>u>e ( fr o o o o ∞ w m m <n m m m m ei n u u ua a aa a ui u ω x x x x x wm ui u w u ui a x x x x x x x x x x a ω ω tii a x x x x x x x x x x x x a ui a ω a ba Α fύ zo ttoo mozo <oo mo z o tt o o o m o < o o om z o o z ort o o mo z <o o om z o < o o mo ; o tt o o

H CM co ι^, m vo r- oo CΛ θ H CM ro ιn ιo r-- oo cΛ θ H CM ιn co r-- oo o-ι o H CM ⁽ iι ιn vD r--. oo oΛ θ H CM ro r— r— r— r— r— r— r— r— c— co oo co oo co oo co co co oo cΛ -ri CΛ r r-- ri-- rt-- rr-- rr-- rr-- rr-- ii-- rr-- rt-- rr-- rr-- rr r--— ii r--— rrr--— iit—-- rrr—-- rr r--- rrr--- rrr---. rrr--- rrr----

CM CM CM CM CM CM CM CM CM CM CM CM CM CM Csl CM CM CM CM CM CM CM

2 ∑ ∑ ∑ ∑ ∑ ∑ ∑ 222 a a a a a a a ∑ 2222 a a a a a 222222 ∑ 222 ∑ 2222 ∑ 22 ∑ 22222222 ∑ 22222 ∑ 2 o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o

Eι _ι h H h h B h h H tι fι h h EH h h tι Eι tι h H tι B h H tι H E-^; H EH h EH H H H h £H EH h Eι tι H B t< ^ Fι h H H Eι tι H tι EH ri

O < tt tt < < ft < < < < < < < ft < ft < < < < < ft < < ft < < ft < < < < < < < < < < ft ft ft ft ft ft < ft ft ft it

υoooozoυooυooozυυooυυzυυoυoυzozzzoυooυouzoooυoυυυυυzυooυoυzoυoυ ro ,S» CJ -3

IΛ υ CM r- t- H OO cn _i co H _. _ cs) > H O <n in oo H in in o cD O co H H CO (n o cM cn H co o ιθ H crι H CM CM cn m cM in cM CΛ o vD <n o cn H ι- ι- ιn ι^, ro cM i^, ιn ιn -M i^, H H oo o ι vo oo - cM "- io ιn ιn r- ^, o ιn oo cD ιn co o co H [— m m o cM H Co cn ii cn co c- co ii in n ro oo ro i' O in o r- co oo cM i" in ιn co ιn oo ι

PM

VD CO O C C CM O VD C O CO VD VD σi CO O C- t— H CM CM C σi in H O C0 t- O O CΛ CM H C₀1' H lι 1 CO 1 <M CM H O <n H lι σι r0 l H O 000-i H ιn r0 O H CM r0 O

Φ Φ r- r— r- co co ι ιn vD CD i vo co ι ιr) ι ιι. ι ιn r r ιo ιι T li in m ii cO rO CM CM ro ro cO CO CM CM CM CM CM H CM CM H CM CM CM CM H H CM CM CM CM CM CM CM CM

_OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO _{O O}O_OOO_OOO_{O O}O_OOOOOOOOOO_OOOOOO_OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

_{H H}HH_HH_{H H}H_{H H}H_{H H}H_HHHHHH_HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH in H cn π σi 'T in σ. iD r- in H CM ' oo io o in cn H oo in '-' CM t— D io oo H ii o cn in r H CD H in c in cM '- D cn ii CM in co cn H oo in o o t- iD o i- i- ii oo co i- t— r— o cM O oo co in cΛ co r— o en r- in o r- o t— O- O CM H CM CM CO O Γ— ro vo vo f r— m r- r— oo f o m m ro oo n ιn ιn m ro H CM [— c ii T H c c cn CΛ _o co ιn ιθ ι H cn co H H in r- H CD θ H H co r "!P Vθ cM H ι r- co co vo σι co co cn ιo σι σι θ cn oo o r- ro r- _> oo r- H H oo io ro in co r- in r- i' vo cM H H

O O H H CM o m ro ^ <^ι m (Il ω m ^ ιn ιn ιn ln Φ ^ ^ p^ <. ^| 1- l Φ ln ln Φ ". d ιΛ m <^ω ιΛ ^ m ιΛ B ^» ιΛ H d d rι ι») p^,ι Φ ιn ιn « lfl "r 9 "|^| ιn ι '-■ co ro co co co co eo eo co ro co co ro co co co co co ro ro .o co co eo co co eM CM CM N

r- o in r— ιι co cD VD cM <τι cn r- r— m ro H H Co cn cM cn cM cn H cM in r— H H CO H H H H Γ- — ^, <n ro oo o ιn ιn r- H oo ιn cM iD CD r— co i c t— oo vD vo cM vo co H CM O cn co t— cM H CM ii C t— m cn vD o^ m oo oo σi oo in i— ' VD O CΛ ιi "» ιn co r- H co co co r- ιn cM -θ co ιn H co H H i-- cΛ vo cM H o oo ι H t- ιn o ' CM c— ιn θ '-^ι H iι ro o o H i^, co in cn io co cn o in o o H r- '-^, <n H CM r- H ' H CM Co cM i' CM '-^, r- H ro H <o to o oo oo cn cM ' i^, cn cn t— •- '-Λ in r- cM oo 'r iTi co oo H H co cn cM cM O CD

O O CM CM o O O CM CM CO O O O H O O O O H H H O O O H C n c c f T o r iⁱ . iⁱ i o D in o o oo c o co I I I I I I I I I I I I I I I I

_) ιn -) ιn ln Φ Φ I- Φ Φ M" ^ M-• B B B B B B B 01 l^ fl> I^ IΛ Cl (Il lI\ O O O OO O O O O O O d d d d d t. (^I N I ( O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O H H H H H H H H H H H H H H H H H H H H H H H ιn ιn _θ - ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιθ ιn ιn ιn ιθ ιn ιn ιθ - ιn ιθ ιn ιn ιn ιn ιn ιn ιo ιn _^ o υυ o υ o o υ υ o υ υ oo o oo o υ o o υ o υ υoυ υ υ υ υ υ o υ o o υ o o υ υ υ o υυ υ υ υυυ υυoooo o o oυυυ o o oooθ D D D D D D _ DDθ θ θ θ θθ θ o o o o o ooo o D DDD _. D D ω ω ω w ω ω ω ι_ι ω ω ω eH θHeH PH i-; ι-i rt θ θ θ θ θ

«tf «tf tf _1,-H ,J J HH .J ,J H^qH3l_ α;0- l_ c ^ρ _Jθ' i-j P. o o o oj cij cι< i-ι _ι α4 θj rt rt rt rt i5? rt rt rt rt rt rt J H Hi j a c-Mi e, m o o mo oo Qozo < moQ .taI C o υoooozυooυυozυoo mυoQoWzυNXzXzz rtυυoυmoυaooυz tυtoo mo oo oo. αo ωo wo Nozυ <oo mooooozυυo mo B ι^ o d N ) ^. m ω ω B ω m ιJl σl CΛ m (^ m _ Φ _ - _ θ - _ (∑ι co CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

o o z oo o o oo o o z o υ oo oo o o z o o o ooo υ o o o z o o o υ o υ o υo υ z oυ oo υ o z oz z z ooo o oo υ z υ

oo in o o CO «T d _l O O B Ill d ( "f n θ lθ m "- B h d 0 01 B I^,l C. IO O ". l'1 01 IJl ιr| in d B Φ O\ Dl ω θ <JMO ( r" Φ <11 l ( r^, 0 ( Φ lO ιn "l^, ιπ B 11 in CM T H O d ιπ ιo v M ^ B ( d O ro co ιf| ^ B ιo o ι^s ^l f rJ ^ o ^- fO B l-) d lfl ιO d ^ (Λ σ^ o^ O (^,^ r* O ^ Λ ιO Λ ^^, w ^ ^ σ1 "? ¹^^, 'l^, co m i io vo in cΛ in o co co in io ro cn co co H oo H n r- r- oo o σi H iθ H θ oo o cM to o. H <n H CM H θo ιn r- r- r- m o cM r- o in cM CM i- CM H r- ro rM ro

H H CM CM CM CM CM CO ⁱ CM CM CM CM CM CO CO rO CO CM H CM H CM H CM CM H CM CM CM H CM H CM CM CM H CM CM CM CM CM rO CO CO I CM CM CM CM CM CM H CM CM CM ooooooooooooooooooooooooooooooooooooooooooooooooooooσoooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H N ι . o ι^,)

H CM O B ιJ d <)i n θ d d N d d l!> r- N (Ii m » O B r_' B O I- l^,) 0010> d Φ I~ n n B I<) O I" MI) <l^, <^l « V ιn N d Oi n d '. f Φ Φ |ⁱ ( rτ- d B en π^ N ι- Φ ^ '. ^^ β B ω ι Φ ( l '^ » ^ ιΛ ω H (^ (Λ l lΛ ιo _ _ ι ^ ιn Φ <)l o σ^ o (. v N <Λ ι ^ H N ft ln m ol (S ln ^ f n co ι c«oI co r^s- ^ O IΛ d B O ιn B φ 1. (^l 010 ^ d O O β n n (M » (M O Φ d Φ O (M O ιn Φ | l Ol d ^» ^• B d ^•» ^^■ (. l ln d (JI B oo m vo co cn m cn o H co cM CΛ CΛ 0000 O H H O CM ^ φ ιn ι ι n (O ιO N H Φ ^ ^■ <. 9 ι«l ι») c. N OO ιJ -l Λ o <M (n (0 ^^ n fl O) Φ Φ » Φ ot) ln » O nni'ii'i n iηv i' i. _'i ro ro ro o ro ro ro co co ro ro co co ro co co ro ro co ro ro co co ro ro ro co co co co ι^, ι '- i' i "- ro co ro co cθ co co co ro co tn ι<l"ι^,ιI> N 0l 5l N( dO

MOm o

o o o o o o υ o o z υ o o o o oz z oo o o oo z o z z z o o o υo z o o o o o u o z υ o o o υ o o z o o o o z υ υ o o o oo r- M" ro JM ■Si

© © CΛ 5 υ co cD _'- H eN cn vD co ro r- r r- n r- r- o oo en csi i' H CM O H cn o oo co 'r cn vo H c- in i oo cN in cN VO c cn cM r- o r— oo m m oo o en cn ro in co o oo o co o r- o r- cM H r- vo in ro cM H O CD CM r- CM H oo r- O H O H -. cn o o i cn o cn cM CM CM OO cn io io oo ro r- o lo m c r cM O i c H cn ro co o r— m m

PM co vo cM co ro H H H co cD oo σi o iD io cM vo cn cM co co ro m m H co ro cM co ' oo vo co oo H ii r- ro co ro H vo oo oo r- H H CM H ro m i' r- cn o H cn o o H

_CM CM CM CM CM CN CM CM CM CM CM CM CO CM CM rO CM CM C CO rO CO CO _'- m m m cO CO CO CO rO CM ' l ' - i' i' m m m m m co io co vD VD vo vo vo vo co r- r- iD r- r- r- ooooooooooooooooooσoooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H H H H m oo t— σv ιι co co ro H H τ m co vo cM m co ιo ι '- H cn co r- m H C_ ιι CM θ. cM co co cM m ι o m c— r— co t— m -r r— CM Γ— in σi m o in -O H VO o cM H r- ιIl « ιη H β » B Φ o •» <n p c^l N ^ ^ι <! o <f <r « N d (*l cN d ι<l O <. "l' l. ι^,) Ol ι<1 •. lIl N d N β O '» ι- d (^ "^ r- ^J Φ ^^ m (<l φ 1^ B (n ^ ^ d ln ^ d r• <ι' "l' ( Φ (Il O ιIl d (^ N O ιn ( ι*l B B ffl ι ιn Φ ln d ^ll O ^■ ^ ιn r> (O B ιn ιn ^ « N ι-- τι^, » β oι l d O 'ι^| o π '^,l ro i^, H H H O H O H CM CM i^, 'T H O <n o i m r- [— vo t— r- io m vo '-r VD r- r- oo t— r- vo vo r- i— ι^| i' i^, CD r— oo cn vo m i' m cn o H CM O O H cM co O H H H ( ro co co ro co ro ro co ro ro co co ro ro cM ro co ro co ro co co ro ro co co co co co ro ro co ro co co io co co co ro ro ro co ro M

^ v β <Il ^ lIl n m ι<l () ^ n d oι ιn n N O N m N ^" l d N » o ι»ι Φ l ln ιN fl σι ^l ". r- N Φ ιIι ιo m d ι d O Λ ^ (M B ^ N Φ ιn d Ol cD M ■. (Il (N ιn ^ ^ » B "^ n o B d Bι^,l n ^ d O ! β B ln ιn l ι^ O ^ o n β "» n N ιn Φ lΛ ι1 d π Φ ιn B lI r■ ln o « ι. o ιn t" Ol B ^ d (^ι « O d N ω Φ m ^ » π o Φ ιn d ^ <. ". ι. w l d r■ "^ fl B ^ '- O B d B N (^ι lJι w ι»1 ιJl ln lO Φ Φ B d l n B (n Φ « fl "r ln B ι^,ι o ιl t cn m ι c H ro o cM H Cθ r- r- r- co r- oo co oo oo r- oo -. o CM co co co co m m ii ii m iⁱ i m i' ro cM i' H co r— r— r— oo cn oo o r— t— co co co in i' i' ro co cM H H o f i n o rK n ro i n f n ri i r. i'. f ro ci n n iη ". ι 'τ ι« ι co co co co ro ro co co ro co co co co <o <o co ro co co co c '- ro ro co co ro co co co fθ ro co co co in

N Φ m » lnΦ m ^ d ( ^N ιn l d (Λ ιΛ d Φ B (^l O " N N ιn ιn d ιJ O o « ^ Φ cN ι^,l d o ιJl « ι ^ ιn Φ n N ^^ Φ ln d lιl d ^ ιn « ^ ιn O - Φ B Φ d ι ^^ ιΛ ^ d o ιl! N m n ιn ^ « o Φ N ln ^ d N O ln n ιn Λ lΛ O V ln ι ^l ln ^ ^ <^l d » ι^ι π ln » (Iι ff ^l! ^. ιIl N O lJι <ιι •> π •^ N B l!l lI\ (1 O Pl N O d N d Φ (Λ d M O d ιIι o (ΛB ^ ιn r- d Φ ι^,^ ^ o o ^n » ι β ffl fl Φ Φ l0 v 5l ι») O l Φ d ^f d (^ ιn -^l in m co m T ιo co r- r- m r- r— oo r- r- t— t— vo co co r- ii io ro n i m m m r- r- cn o o m en o r- cn o O H O H H H cn cn cn oo f- o o H CM O O H cn

H H H H I H CM CM H H CM H H CM CM CM CM CM CM CM H H H H H CM CM CM CM CM CM CM H

e <n e <n σι σι e en σι o o o o o o o o H H H H H H H H H H H M CM CM CM CM CM c co o c co co c c 'T 'i' '_^, ι ιi 'r i' m m vo vo D VD VD CD CD D

H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM C CM CN CM CM CM CM CM CM CM CM CM CM M CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM m in m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m in m m m m m m m m m m in m m m m m m m m m m m

O O O O O O O O O O O O O O O O U O O O U O O O O O O U O O O U O O O O O O O O O O O O O O O O O O O O O O O O O O U O O O O ω ω ω a ω a ω 3 a z z z z z z z z o o o o o o θ Λ ι^ a oi a Λ w a w a ti} h3 a hj D^ a, ^ aΛ p^ D4 D^ , eζ aaaBBHWB x x x x x c in c CΛ tn Λ Λ C oύ oέ x αύ X tf oci oij tf oci tf c-i u ω ω ω u H^ H^ H^ H^ H X X X X X X X X

Oι l- & l- l- Oι tι αι l- < < < < < ιci; < 4 ^ ^ ^ ^ ^ g < ^ < n B B B B B H H H H H H H H M; < |-: ι-i ^ < < < ι{ ^ rt ftj Oj CH &i P_H C_Li p_j -i

H CM H CM H CM H CM H CM H H CM H CM

CQ O O Q rl rl l tt m o Q Q rt m Q tt m o a o oυooυozzoooυ υυωzυNzXxz tt tt m m o a o ooυυoυυoυz zυoo mυooz tυtooomoooooo. o υ o o υ o o υ o υ z υ o o ooυυ o d M n "l^| ιΛ Φ lΛ O ( n <f ln Φ r• lIl O d l n » ιI) Φ ^ ι O H (^ι ι^,1 "l' ln Φ ^ B Oι o N n fl ιn ^ι) ι-. B (!l O ι m » ι Φ ^ B Ol O d ( Φ Φ Φ Φ Φ Φ Φ ^ ^ ^ ^ ^ ^ ^ ^ α) B _ _ (D B m ιo _ ιD _ ιJl Ol ιJl -l ιJ σl m m (I o o o o o o o o o O H H H H H d H c^ι J N σ> σ. <n cn cn σ^ cn cn cn cn (n m cn cn cn cn en cn σ. en cn cΛ ^ en cn cn cn σ. σ. σ^ cn < ι σ» cn cn cn cn cn cn cn o o o o o o o o o o o o o o o o o o o o o o o oo CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C C CM CM C CM CM CM CM CM CM CM CM C^

2 a 222 a a 222222222 a 22222 a 2 a 222222222

© oooooooooooooooooooooo o o o o ooooooo oo oooooooooooo o ooooooooooo oooo o H E^H EH EH E^H E^H EH H E^H EH H EH EH EH EH EH EH EH EH H EH EH EH H H -H EH EH EH EH H H -H H H H EH EH EH H ^H H H EH EH H -H E ft < < et < < ft < < tt tt tt < ft tt ft ft ft tt ft tt tt ft < tt ft it tt it

ooozooooooozzooooooozooooυoυoυozυooυoozoooooozυooozooooozoooυoo rt r- ro

£M

© ©

CΛ

H ( w r ιΛ ln M d m Φ n ^ ι N ^ ^ d ιn « o ^ι m o v _N ^■ <Λ ^ ^ ι ^ B ι o N O O B (n ^ ln o^ N 09 B Ol B σl « ". ln ιn c^ι !Λ - υ a ιo m d fl ln fl σι d o B * ω n n ιn o^ ^ N n ^ ol n ^ m B (^ι o m ^■ o B r- « B β o N ι^,) Λ Φ ! d N π Λ B lJι oι ^• n o ιJl C

O H H H H o o c i^, m c oo vD vD oo o r cM cM CM O cn ii co c H H O CM CM M CM CM co H C ro c M H O " "- "- c m m m 'r m in _' i— iⁱ -¹

^ ^ ^ | _l- ^ _r. [- ^ ^ _r. |~ φ φ φ ^ ^ ι- φ φ φ ιn m tn ιn >n ι ιr) φ φ φ φ φ φ φ φ φ φ φ φ φ φ ^φ

O_OOOO_OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

O n ι. d d ln ^ N O ^ Φ ^ n d ιfl ■. 9 ^ » » ι (1 d ln B r■ « ι! "ι^| c B N ι. r■ ιn ι w cN d N ι^,) l- Φ ^ B 'l' d Φ ιI> B ι lll O B CN ^ N O ln ^ ιn ιn B Φ » B ι (0(0 <>ι ιJl * ιJl O fl ^l N lnιn « Ol "I' l B ! ι. ln n ι^,l lΛ B B B Φ ^ι ^ Φ ^ CN' N "ι^, ^ ^ (N ^ n ^ ( cΛ Ol ι Φ o n '. oι ιn "ι• o β ι. n Φ n Φ d Φ n o d ^ ^ N ^n « d o ι^,l m d ln n n n ιJι σl N v f) d n β l Φ Λ ι o n (N O l(l r• ιIl O Ol B

H H CM H CM CM co o cn oo r- _> H H CM co o cΛ oo o3 co ι ι m ro cM H H θ o cn ro i' vo ro rθ H m r- oo αj r- oo m o θ o θ H θ θ H CM <n o H CM co cM H H '3^ ιι ιi "- ιι ιι ιι ιi ( c c ι ι^, ι^, '- c < c ιι ι '-r ^, ι^, ι^, ι '- 'r cθ "- 'r ι ι '- i ι ι ι^, ιi '-^, ι ι ι ιι m m m m ι m -. ιn m ιn co cM co cn oo H '- i CM cn o vD i oo i i r- cM O rO '. H H cM c co oo cn cD m cn vo cn co co co co m co o cn vo cM i i' cn co oo co oo co oo co c -M- H cn oo ii oo o cM cn r— _> CM m o i< cn ii o cM ro vD o i _> ι cn r- o o m iπ i'i N Λ Λ irt v ift Φ ii '. i'KM '. CM H O O O H en co <n oo r- t- vo rl 'l 1^, 1 ^, 1 1 ^« '- 1^, 1ⁱ 1 1ⁱ 1 « 1 co co co co co co co in

^ fN d r- O n o o αι ln <Il » β B ^ d B (ι n O d N Φ N n •» n <' Oι ol (η ιn l O N r> ι^,l β d <^ 9 ^^ N '- » o> Φ Φ (^,ι | 1» r• (N B O B ^ n B B ^l ⁽ o n ιn ιo n B B o ol d d n lrι ^ n l r■ ι^,l Φ v c 9 « <ι' n ι/l ιΛ Φ W fl ^ ^ » m ι^,) ^ι ^ B N lfl o> o <» <. ι^,l Φ n oι Φ B ιn * o ^ oι ιn ιn o <^ ιn ^ » o ιfl ^ β Φ O ^ <ι m o Φ O ιn oι r" H ffl n o ^ fl N Φ O O o ιn Φ ιn β ιn ιn Φ B ^ Φ ι ιo ιn w ι^,) ^ ιn d ιJl O ⁽ n ^•l' n 'ι^, 'ι^l Λ ιn v « « » « n n n n ^ 1|^| ( ^ι » 1l^| ι^,l ^o n ιn 1. N O O O ιJl »o o ιll O B r^■ ιJl ιIl -l β B O O O d ι ι^,l ι!ι ι!l Ol Φ O N

CM H CM CM CM CM CM CM CSI CM CM CM C CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H H CM CM H CM CM H H H H H H H H CM CM CM W

Φ Φ l- ^ ^ ^■- ^ ^•s ^ ^ ^ α⁾ B BBffl BfflB O> (l^ Ol αl <Il Ol Ol 0^ lIl C (!l O O O O O O O d d d d N N CN (N l l1l^,) ι^,ll^,) l^,l n τ^ » » <^ v 'l^l _'l^, CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CO CO rO CO CO CO CO rO eo ro cO CO CO mm mm mmmmmmmmm mmmmmm mmmmmmmmm mmmmmmmmmmmmmmmmmmmm m mmmmmm oυυυυoυυυυυυooϋυoυυooooυooυooϋooooυυoυυυυoυυυoooυoooυoυoυυooυυo

M ω ωi io oi ra to n ra in to ft iii Mii di tii

K K K >H >ι > ι ι >ι ι > >ι n B Oi n il) Bl oifeωωωwωωwwwwwJ^HJi-ivJ^jiJ^HqjHji-iiJtrrtrt OTwxxxBxxxxBXX rt rtrtrtrtrtrtrtrtrtrtrtrtrtr33Hl aϋ- l- lϋ l- K Q O Q Q Q S

B B B a B >H Hl ^ Hl μ) >J ^

Oⁱ iii C^M i-i HH i-i μi J i-i i-i i-i i-i rt rt rt rt rt rt rt rt P (-l (-< C-l Cl4 (-l P^j (-< 0H t-l ⁽-l > > > > > > > > > > > > > rt rt rt I CΛ CΛ CΛ CΛ CΛ CΛ O O O O O O O

H CM .. CM H CM H CM

W W -0 tt moaωco tt moao tt m o a a ω ω -a υ υ o z oooυooυzzυυoυυoozυυoooooooo O rtO O mO O O < o υ < m tt m o o υ υ o o o o z o υ o o o υ υ o υ m υ υo n « ιn Φ B Φ O ι n 4 ι/1 V B lλ o N n « ιι) W B A O N n « ιfl Φ n o d ι n « ιn Φ B O o N n « ιιι ι- B tn o H ( n ^■. ιn ^l (^l N ( N N (ι rl ( n c^ n n (o n n n <- "^ 9 ^^, » '. » « <f fl ln ιn ιn ln ln ιn ιn ιn ln ιn l- Φ Φ Φ ^ ^ ^ ^ ^ ^ '-- B co ω B

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O

00 co co ro ro ro co co co ro ro ro co co ro co ro r n ro ro ro co co co ro ro ro ro ro ro co co co co co co co ro co co co c^ rH VO

₂₂a₂ aa_{222 ∑ ∑ 2222 ∑ ∑ ∑ ∑ 2 2 ∑ 22 ∑ 22}2₂2_{2 ∑}a₂₂

O ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

Eι H H H E_ H fH E_ H H H H h E< h h H H h h ri h h h h ^ B H h H Eι tι tH h tι Eι tι H H h EH Eι H Eι h !_ h H Eι EH h Eι H Ej h h EH E. H h rJ

O rtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrt rt rtrtrt rtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrtrt

oozoυoooozooooozooooooozoooυwzυυoυυυ zoooooozoooooozzoooooozzoo rt rt f- ro

JM

© ©

CΛ

H o cM i' in ιn en cM co e_^ι o τ co ιn -- r- H vo vo H O O CO o oo in ro σ. r— ' in cn cM H CΛ H θ co c'. r- co _. en en σ. e_ CJ in o o cM m co cΛ VD t— c o c f o vo n ' C-M.i H—i —Hi H CD r- r- H CD H VD C VD ID H O oo oo ro co H ii imn ccMM CCMM OO VDD Oo Oo imn HH Oo CσΛi rr-- imn ccoo ccM H CO PM m r— oo oo co r- i— c— CΛ H CM CM O π m-, vo vo vo oo cn H cn co vD oo cn cM r- o cM CM co cM co co ii -i i i in vD in co H cn cn cM ro c co i— eo o o i' in in vo m o m lO io vo iD VD VO Vo vo io io r- r- r- l- t- r- c— t— r— t— c- oo r— [- r— i— r- t— co oo oo oo oo oo oo oo o o o o o o o o o σ. σ. o o o o cn σi i-. -. CΛ cn σ. en co co --

HHHHHHHHH HHHH oooo ooooooooooooooo O_O_O_O_O_O_O_O_O_O_O_O_O_O oooooooooooooooooooooooooo ooooooooooo_o_o_o_o_o_o_ooooooo ooooooooooooooo oooooooooooooooooooooooooo

H H H H H H

O O CO O CM VO Γ— H vo ro <n H "- θ vo o^ co oo vo cn <n ιn i' θ θ cM θo o oo o cn ι— cn r— oo r— H CM m co o σ. oo '- iι co vo m oo cM i— "- <n ro i' r- i* o o o o oo o m ro o co τ cn oo co co co m r- cn ro t- CM co co ro o oo co i' c 'r H θθ ι^, o m ιo oo m r- ι. ro vD io eD m ι^, en H in ι^, o ^, en oo r- CM θ cM Cθ o o ιn _' Vo i— o co m ro H Vo ro cD r— o oo r- cM CD oo oo oo cM CM co ro oo r- oo io i' en co co o H m i H ro VD ιι co H r- ι^| ι^, co ι cM CM H c_ oo m o c- m H co ro m co co r- σι c H c ' m -i 'r i m ' m i' c ' m ' ' r- r- i- oo ii co ' -. c cM i' m '- '- cD -i r- r- vo r- oo cΛ θD m ^ι ( ( ι^, co cM i' CM θ θ H θ θ o o m m m m m m m m m m m m m m m in m m m m m m m m m m m m m m I I I I I I I I I I I I I I I I I I I

H H c- i' m co co cΛ CM Oo m ro H oo i m 'r ro i- en co ro vo co o cM Oo m cM oo oo o co H l r- H m CD CD Cn ii i CM O OO H H CO CM m O i— " ii H r— cn r— cM <n m ι-H i^, r- co ι— m m cΛ ⁱ o oo co o CM OO O 'r H CΛ r- oo co vo iⁱ cM H CM 1" O 00 •- o co H cn cn m H oo ii co H r— m iⁱ c cM cn i— ⁱ r- o o o cM m r- r— vo co o H cn iⁱ iⁱ H co ' CO c co f en o H VD CM CM H CM O oo CM I- 1* vo t- "- O O CM CM H cn co io oo c- O H m cn iⁱ r- oo o oo m cΛ cn en n cM co o H θ ro co co cM CM H θ co co o cn o. o oo o o o oo oo oo r- r- _ι σι _ι oo co o θ H oo r— c— c— vo vo iⁱ co vD oo oo r— oo co m i m vD r- co oo co cM CM ro ro ^l ι 'r ι ι ι^{ι ι} ι ιι ι ι^ι c ro ι c ι ", c c c ro co r co c c ro ι^l ι^, ι^ι CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM

H -- oo r— m vD oo co m cM vo r— co m ro ro cn oo io io co m "-r- iO " * H r— cO T ro m cM O cn cn cn r- c oo m co i H cn cD o r- co o m cD cn cM o cM co vD iⁱ oo cM oo o co cD m o o cM r— i r— H H r— t— cn m oo oo m H H cn vo m ro co cM co co oo i¹ ιι CΛ oo cM i^, r- i' C CM cn ιo co H CM CM co cθ ι- o m vθ ι- σι ι lo iⁱ en vD H r- O i' i— ro en cM co cM m co cn r- m ii i' o o en in co o r- i- "- ro cM H r- CM CM CD en o en t- in oo o oD co i' cn i r- cM H cn co H m m '- H H oo

CM ΓO OO OO Γ- vo cn o oo co 1 1^t 1 1^ι 1< C0 CM H H CM H O CN H σi 0000 O H I- VD m τ lD lι r- <Tι σι O CM cn 00 O O CM H H CM C01^, 1^, CM CM O cn CM CO 1« CO H O O

CM CM H H H H H CM H H HHHH I H

^J ^ι' ιn Λ ιn l ln ιn ln Φ l- ιo ιι⁾ « » ^•-^• ^ ^' ^ ^ r^■ lD B ffl B B B Ol(I10l Ol Ol Ol ιJl ⁽Il (Iι ιIl Ol σlm ιJι ιJl o o o o o o o o d d d d H CM CM CM ro co co co ro ro co co co ro co co ro co co co co co ro eo ro co co ro ro ro to ro co co co co co co co fO co o o o o o o o H H H H H H H H H H H H H H H rH rH rH rH m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m vD vo cD io vo vD VD co co iD CD iD CD io co vo co vo vo io cD VD CO CD CO VD oυ υυυ υυ υ υ υo υ oυ υ o o υ υυ υ υυυoϋυo o υυ υ υoo o υ Q Q D Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q QQ

D D P5 g g; oή « « « <-; « r; « « r; cH iτ θ^ H^ Hi x x x x x x x ω w DQ ω ω ω w cΛ C CΛ Λ ω c ι H >H >H < H rt rt rt rt rt rt rt rt X X X B a x χ c o c C C CΛ w

O O EH H E^H H EH EH EH CΛ CΛ CΛ C0 OT CΛ rt rt rt rt rt rt rt rt O O θ υ θ O > > > > > > > > EH EH EH EH EH EH EH rt rt rt rt rt rt rt rt rt rt rt rt rt rt rt rt > > >

H CM H CM H CM ω a H CM H CM H CM oozo ttoo mooo tt mo tt moao ft m o rt m m o o tt m a o m O Q Q ft ooooozoooooooz O O O O W Z O O O O O O S z oo o o o o zo o o o o o z z OOOOOZZOO en o vD t— co CM CM CO 1^, 1 1 "-. H H H H co co co c^

o o o o z o o o υ o υ υ z z o o o o o o o z o υ o υ υ o z o o o υ o o z o o o o o o ϋ z z o υ o o υ υ υ z ϋ o o o ϋ o z o o o rt _ rt r- ro JM

© ©

CΛ £

-?

H CM o r H it c o ii r- t— t— r- o ii oo c— co CO I H Γ— cM H CM co c vD i c i m c cM oo ii oo o c co co cD r— vo co i o o H co cM cn H σi σi r— m

CJ m c m ii co co m r— t— cn en cM O t— CM m oo cn o m r- τ o ι cM CM cn co r- <n co co co co o H m c_ oo _> o r- ι— m r— H CM H co c— vo cM cn o m vD o cM H oo m

PM _I' H _CM O H r- CM H Cn cM I' CO I- lO cn ii O H rO VO lO OO rO H l H CM H CM O O m H m cn σ. lO m H CD O CM r- CO rO CM CM m CM m H H H CΛ H CM O CM CΛ CM H CM r- CD OO OO Γ— VD VO VD CO I— r— r— r- ιn i" ' « ι ιn ιn m c r c ro r c < c < < ι f i" < cM CM CM C r (θ i' ^, ι^, C M <ι cM rιj c Csi c H c M (M CM H C C ^

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H H H H H H H H H H H H H H H H H H H

^ B ι o _ r. <J lJl r ^ ^ . 'f ιo w ι (^ Φ o ^^ι ι- ^ ιn ^ cD ι ffl ^ ^l B O (ι ^ w Φ o m m v H Ol ^ Φ N c. m _ ^ N N <. O « ^- N O ffl - H (^ _'J ln ^■ d ^ ^ <^ ι^,) d O » « B (O β d B Φ ιn ι^,) f^|l r" ^■ N CN 9 ι») O d ^ ^» (1 <^ Φ t1 N Φ * Φ ιn Φ O ^' "r r• B ^_' ^ N C^ ιn ^ d ιη oo co r— H in o H ro co H oo H oo t— vo cM ^, oo oo H m m o H H o» m oo o H co i' co m co o H oo o vo H r— H oo o ii m i t— "- "- <n t— H H O o oo o cM CM ii

CM O O O m cM CM H co co co ι^, m co ro co i' co i' m co c- co ι cM co ι- oo cn vo vD m oo σ. <n H oo oo r— t— lo cn m o H oo oo cn c- σ. o cM co o H oo cM co '-

I I rH ri ri r rH rH rH rH rH rH rH

B n l Ol ι»1 o m o ^" ffl ^ !Λ B Φ ^ ιn d ιn n r• Φ ^1 l«) M o^ n n ^ lη N m ι^,ι ol ι^,) ^ ll1 lJ ^ d o^ ^f o o o o <' ^^ o o N ^l B l -l B o r- o co ι |— '- m σ vo co m ι— o ro r- H ι ro co o o m ι^, o cD H Co o o cn vo cM <n H <n vD H θ <n co m (X5 H r— r- m m ro H iι co H H oo r— H o σi m o cM

^ o N » N Φ ^ » w « o ^ ιn o H « « ω m o Φ Φ Φ W N n ιfl ι o ^ ri nΦ ffl ιn « w o ιΛ Φ β l N N Φ H O ι^,) n m » o Φ B O N Λ ιn r• -) CM

H H H O CM H CM C H CM CM H O m m co co m CD 1^, 1 C C01' 1^, m CM H CM H O O Cn CM e01i 1 '. CM CO CM CO m vO vD r- OO Cn c01' 1< C CO CM CM eO CM CM r C rl CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H CM CM CM CM CM CM CM CM CM CM C^ in ι B ιn n d n n ( ιJι » -l ι)ι N Ot ιA Φ _

00 CM CM CM CO '.ⁱ m io r- vo cM CM H H co '- m o in σi oo oo vD oo o^ cn o o o H m H CM H H rO 'r io co o cn oo oo σi oo -. r- oo t— r— r- vo in in oo cn cn o. rH ri rH rH

Q α Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q D Q D D Q Q Q Q Q Q Q Q Q Q Q Q Q Q D Q Q Q D Q D D Q Q Q Q Q Q Q Q Q Q Q Q Q Q > > > > > > 3 S 3

H CM H CM H CM H CM H CM H CM m o o tt m ω - o o o o z o o o om Q o oQoωz--- t z tott o o moQD < moo tt moo ft moαt-iN < moαα < moo < ^{' " "}OOOOZOOOOOOZOOOOOOZOOOOOOOZZOOOOOOOZOOOOOOZOOO ιJι o d o θ H H CM CM CM CM co co co ro a a S 2 o o o o < < tt

ozυυoooozzooooooozoυoυoozυooooυozzoυooooozυooυoooooυozυooυυwυzυ

ii r- co co m m cM ¹ o r- c- m -i o cM CM r— co H i> ι ι- "- o vo co cM r- e_ o ι ιι θ H CM CΛ σι io ιθ H ro ι^, ι- o m ro ιo o H H ι- cn vD co m co co r- CM vo t- H H O Oo o r- r- oo m r- cn cM o O CO en cD m vo o co o r— o «. r— c— H I— m ro m ro o ro oo o oo ro ro ro o oo oo oo c— co cM H "- Vo m vo co cM O H CM m H co cM iⁱ o o cn o cn o oo r- o cM cn co r- vo H Co r— o m H H rθ H oo o o cΛ θ "- to o <n r— OO CΛ C— ι^ι ι^ι c H CM vo r- c— _ t— -. co cn oo m

CM CM CM CM CM CM CM CM OI CM CM H CM H CM H H CM CM H H H H CM CM CM rθ CM rθ Cθ rθ r CM <O CO CM rθ C C01" CM CM CM C CM CM CM CM CM CM CM CM CM CM CM CM CM CO CO CO CM CM oooooooooooooooooooooooooooooooσooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

o cM cn co cM H i CM Vo vo H σi cn cn cn H Oo m co r- vo oo ro i H io co i cD ii rr—- lloO vVDD CCMM OO tCo cCMM cCnn oOoO cCMM min HH CCDD cCoD I l O CM CM CO cn CM cn cn cn o o ii CM c- c— cM vo cM o cM VD oo o co r— t- o. co H i' en H co -i cΛ CM .- en o r— en en m in m cD ro co co in co o r— r— r— ,., „ . _ ,„ _.... ι— O r— CM "- co cn io i t— H r- vo m m vo σ. o H r- co co cM θ H m vD o vD H σ. m ι— o cM CD m ^, o r- o m σ. m ' H i ι— H cn o t— co cM O cn r- lO cM cn αi co cM ' in o o vo m

CM co ι< ι^> ιn co ιn "-F ι _> _> co cM H ro r— oo r— vo cn oo i— r— ι— r- r- oo r— oo oo σi oo m oo oo o H H CM r— r- m m _ vo r- m vD i m m m i' <o < m ιo co m cM H ri ri rH rH rH rH rH rH rH C^ C^ C^ ^ rH rH ri ri rH rH rH ri ri ri rH rH rH ri ri ri ri rH rH ri rH rH

in

O d d d d d cN N l N (l M C' N n n n n n n π « 9 "ι^, <^ 9 "|l 1. » w ln lO ιn ιn ιΛ ι ln o Φ Φ Φ Φ ^- Φ Φ Φ Φ Φ ^ ^ ι-• ^- ^ ^ B ffi

CM CM CM CM CM CM CM CM C CM CM CM CM CM CM CM C CM CM CM CM CM CM CM CM C CM CM CM CM CM C\. CM CM CM CM CM C^

Φ Φ Φ Φ Φ Φ Φ Φ ΦΦ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ ΦΦ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ α Q Q Q Q Q Q Q Q α Q Q Q Q Q Q α Q Q Q Q Q D D Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q D Q D D Q D Q D D Q Q Q Q Q Q Q Q D Q rt Z Z Z Z Z Z Z Z D D D D D D D D O O O O O O O CΛ c < « c fύ (_ ι4 iΛ c c OT cn c c w w ω ω ω ω ω _ι o- c_ c_ £_ c_ _; ; H Xύ x_ x Λ x xύ x x H >H H 5H H M W W W M (_ W M H3 H. μl hJ H^ Hq l-q lJ I-l lJ rt rt rt rt rt rt rt EH EH EH H EH ∑ a a S g ε ∑ H H f m o Q w Z O O O O O CΛ O z υ <

oooooϋ zoυoυoozooooυoυz υυ oυooo z z o ooooϋoυυoo z υυoooozυooooo z ooozoo

Φ ιn β N MII MIl «- 1 1 1i vD VD vo vD

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H H H H H H

^ _ ιn ^ ιn ιJ d ln ( N « d Φ ( O ^ ιn < B ln » B n r^■ d B d ιrι «l d '. ^- o rl ( B ln ι^,l O ιJl O B o n Φ ιι) β < N N n ^ι Φ ιn ι^,ι ιn B <ι^ι d B B ^ ^- ln » B ιJ> ι-• π ι <Il ^ ^ Φ d ιJ^ d ( ιn d o o d ϊ ln ^ Φ l m ιn ^ ln H '. ι ι ^ N ^ι ι^,l r• ( N B Λ ^^ o d Φ (- t" l- ^|- CN r— co m co i' ii m r- CM r- H m co m H vo o vD H co cn vo H H O ii i' i— r— o in t- vo co vo H en co m co cM r— I' Vo io ro o H co cn cn O H O Co in cM i' o en u. o oo o o o H cn o o cn co r- o H en r- vo in co in i- co co i CO CM CO Ii rO l' li rO CM H H CO CO CM CM CM CM CM H O O O O CM rO CM O O H O M H H CM CM rO CO CM CO CM rH rH rH ri ri ri H I I I I I I I I I I I I I I I I I I I I ln ln ^^ n N ι»l N r B O ιΛ d ι o ^N σl Φ I B Φ rl (ll B v o » N ι^| l!> Φ ^ ^ v o ιn » O Φ π ι^ ι. o^,l v n Λ <ι^l ^ ^ <ι^ N B . l ^ N Φ B (!l m 9 ιn n •ϊ d ln o ol « ^ » o n ^ n o ln m ιιl N * <n d B l- O ln ( r• d ι>l n ^Iι oι l" Φ ( d ll) ^|- l ι" B ln o o l/) ( P10 ι. ιη ι>) m ^ σι σι ιn N "^ <^ι n N c^,^ rι o <^ι o o B ιJι ^^ lπ Λ ι1 r" ιn n o O « w < N <ι o Ol n ^ ι N ^ d Φ d ιn ! B Φ ^^ * o d O O O d 01 N N N n » <l^l » N N N d d O d lΛ I*) O d » ιn » II1 0 (Λ ιn O B ^ « ^ Λ ^^ * M W 01 » ^O OI -I O ^ Λ l/) ^ III IIl Λ I^,l l^,I N « « n rH ro ro co co c cM co ro co c co co co co co co co co co ro cM co ro co co co ro ro co ro ro cM CM co cM CM CM CM CM CM cM CM CM CM CM c^ in

CO r- 00 H VD CM 11 en oo -i co cM oo co r- r- co cM O H cn co oo r- io H oo H O ' to σi m o cM m r- H O [— lo ro cn ro o cn o r H H CM in H iⁱ t— in H co cM io CM co T co m 00 H _ι ". co m H O n vo m en H O T CM CO H co r- cn co cD r- o co oo cn vo co m CD cn H co ro H CO m O VD O O m OO CM r- O I' OO vO CD CO CO CD CM m H H H CO H cn H σi σi r— r— cM oo oo cM O H CM '-^| vo io en cn ro cM co co cM m m iD oo i^| H ^, r- H [— " CM H O CO CO CM O CO CO Cn cO CO CO OO H r- CO H Iⁱ O CO co H O o H co m cominr-mmr-com ι*t— cooooocncn σ. σ^ cn<nσι θ H en cn oo o r— o oo ooo H CM H O H O ro i' ro ro in in co i' co cM CM H O cn

1 1 1 1 1 I I I I I I I I I I I I I I I I I I I I I I H H I I I H I H I I H

oo oo oo oo oo oo oΛ n cn cn en en cn o o o o o o o O H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM co co co co co ro ro i 't' ⁱ i ii iⁱ m m co cD co CM CM CM CM CM CM CM CM CM CM CM CM CM ro co co co ro co co ro co co c co ro c co co co co co co co ro co co ro ro co co ro co co a a a a a a a a a a a Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q D Q Q Q Q Cl Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q D Q a Q D Q Q a a ~ a a a _ a_ a_ a_

_ α rt a; j j j HH Hl O O O O O O O rH >H H >H EH H EH

,_i Hq H^ Hi Hq Hq B χ a a a ω ω c_ c_ ω ι_ w (_ι H >H >H >H _rH _rH ϊM H _rH X x x x it ft ft rt rt rt α: α: o- X o- : o- H₄ H. H^ H ω ω ω

H H H H H H fi Fl ti ti Ei Ei ti J ^ rf Hl J lJ iH iH il il J J J j Hl ij Hl > > >

H CM H H CM H CM oo mυυυQoz <υoo moooooz totoooooaooo m o υ υ o o o Q o o M N z rt mooαωwκιx tt m tt m o Q z o υ o υ υ υ υ o υ υ o z υ o o υ o o z o o o o o o ft υ o o z < υ υ

o o o co o z o ϋo υ υ o o z o oo υo o z υ υo υ υ υ υ z o υ o oυ o z υ ooυozoooo o z o υ z zoυoocΛ z υ υ oo o rt r- ro

JM _i

© .• O CΛ

H oo H co o T i o m m o i cM CM CM H cn cM CM H co e vo o oo co o cD oo ro cM ro o m co r- CM H CO CO t- o H m oo vo o. o co oo cM cn o cM CM CΛ CM r- r- CJ σi H H Vθ H «-r^ι m oo H i^ι co ro vo cn ι co oo H θo cM CM m '_ co o cn i ii oo r- H CM cn m m co m oo m H cn ii cM cn en co m m oo cn co co m m ii c- σi oo H H PM m m m c- ro '- ' ro ro m vo c— r— i m cn m cM H O co oo vo co to σi vo co o vo H CM c— o cM c o "- O O 0000 CM CO i- in in m cM O o ro cM r- co o H co cM lO VD VD VD VD vD CD vo vo co vo co co vD co co co cD io iD r— t- oo co r- VD CD VD σι σι o o σι en cn o o H ri rH rH O O ri rH H H H O O O O O O en en en cn cn en

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH p) ^•1 o\ lIι o m o B ι l ^l O B ^ ^ • d O ln ιn Φ ιn ιn N » ln ( 9 ^ o v d n B B r> n ^ o cΛ p^ cll N ι^,lOl d (N (' B l^,) o ιn M •» ιn w H n B Φ n N w o o N β * β <^ι * v ιn ιΛ o ι. N ^ v ιn (^ Φ n Φ M ^ n * ιπ ιn Φ ιn B Λ Φ o « βι ιo ι Λ ^ v Φ * n ιrι » « ι^,l o « <. oι ιIl fl O Λ N < N N Φ N O ^o ιn o ιTl d J> (N ιn ιl ln <ι^| N Ol n ln fι Ol ιn ^• l- » B ( d d » « t10 <ι^| ι^,ι o ιll ^ o o n « o 0 » ιn Φ B

CM CM H O H CM CM CO CO O O O CO Ii ID CO CM ro vD i- oo r- i- r- r— cn o cn en H O O Cn O H Cri H H CM H H CO ^•- 1" 1" in i- o o -. -. α. o oD f- r- co in in I I I I I I I I I I I I I I I I I I I I I I I I I I H I I ri rH ri I rH rH I rH rH rH H H H I I I H I I I I I I

I I I I I I I I I I I I d ^ lΛ B O\ « ( na r• β ^ o Φ ι-• ln d ln « d l <J O (^ d d « B ^ ιπ w n ^•1 ln o ^" Φ N O o r■ ln o^ n ( fO Φ ln cι lO π o ι^,^ r- ι^,) Ol » n n Φ ^ N ιn d ιι Φ o o d (^l B o n ln l/l B (Jι β ιfl (!l β β Φ » ^ ι(l ιn ιn r_' » ιnιI^ d ιl ιJ\ Φ v » Λ ι^ι Φ d « » d » o n Φ Φ Φ o d Φ o m cM cn vo o r- t- oo cM m o ι^, ci) oo ι r- ιι vD VD m H CM H m co o H c 'r io ιo m cM m ι* m vD cM σv m o H H ro m ι^, vD cM m ιo co i' ro m m r- co ro ι- CM m m ro in in in i cM O cn co o o ex> <n m or> α. ec r— <n o H H H CM CM CM 'T H H CM co H CM H CM co ι m cM CM m vo r- oo m ι ι^, co co c vo r- oo cΛ co m r- oo oo cn r- _> rl CM CM CM CM CM CM CM H H CM CM H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM in

« ιAβ H N 40 o o o ". ιo ^■» n « ιn d ιn H B o I. n 9l ^^> ^^■ βl I H I I I I I I I

Φ Φ ^ ^ ^ ^ ^ ^ β β B B Cι Ol ιJl (Il m (I^ σl m o o o o o o o d d d d d ^^ι ^N ^N (l (l ^l ^^ <ι w l ι<) m n n n ι v » » v ^P ". ro ro co ro ro co co co co co co co co co co co co co co co co co ro co eo co co ro i' i i ii i' ' ^ lO CO VO lO CD CD VO lO CO CO VO lO CO lO CO VO CO CO VO CO CO CO CO lO CO VO VO lO CO CD lO CO CO CO VO VD VO VO CO VO CO CO VO CO CO VO CO CO CO CO CO VO CO CO CO VO CO CD CO CO VO CO CO ^{Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q} Q ^{Q Q Q Q Q Q} Q Q Q Q Q Q ^{Q Q} Q Q Q Q Q Q Q Q Q α Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q

EH _H fH frH EH θ₄ C_H αi £_ CH f_ « C_H , l _H iJ j j J B D O D D D D D O O O O O O O Λ Λ iϊ iiiϊ Λ i- w in t. io w n n oi oi oi oi oi w to tn oi iii iii fc di αi Oi

_? ω CΛ CΛ OT CΛ CΛ CO CΛ CΛ rt rt rt rt rt rt ω ω w ω ω c_ ω ω χ p- B. o- o- ι_; _, u i- ω ω ω ω H H H H H H H H H H . >H . H ι < o. tt tt ft tt < t tt > > > > > > μi J HP H3 H3 H? ιJ Hq i-ι Oj C-ι l_ι l- (-ι l_ι C C C C CΛ CΛ X X X X a a a υ θ O O O O EH EH EH EH EH EH moQw mo Ho CQM tt m Ho CoM mo Hα CαM ft mod ft mo H CM H CM tt m o a Q ω w oυυcΛυzυυoυυoozoooυoozooooυoozυυooυυzυooυoz < m υoooozoozz < o υ o o CΛ z o o o m υ o o Ol O (Jt σl o

00 oaaoaooaoaao∑o∑o∑o∑oo∑o∑o∑oa∑o∑oo∑o∑∑o∑o∑o∑oo∑∑oo∑ao∑oo∑o∑∑o∑o∑ooaoao∑aoaoaoaooεo∑o∑∑ooε∑o∑o∑o∑o∑o∑o∑oo∑∑oo∑∑o∑oao∑o∑oεo∑oo∑∑o o ft < < < < < ft < < < < < < < ft < < < < < < ft < < ft ft < ft ft < ft ft < ft < < tt < < < ft ft ft ft ft tt ft ft < < ft < <

o o z υ o υ υ υ z υ υ o υ oυ o z o υoυo z oooo o o o o z o o o o o cΛ o z o o o υ o o z υ o oo o o z o o o υ o υ o z z rt rt t- ro <s

© _s © CΛ

H ro H m cM CM cocx> m r- _>oo ι< H CM 1" 00 CJ N ^ vo m CM

PM H CM ι^n ¹ ro o o o o o o o o o o o o o o o o o o ooo o o o o o o o o o ooo oo o o o o o o o oo o o o o o o o o o o o o o o o o O O O o o o o o o o o o o o o o o o o o o ooo o o o o o o o o o oooo o o o o o o o oo ooo o o oo o o o o o o oo o o O O O

H H H H H H H H H H H H en io m m H co H oo ro co oo H H OO CΛ σ. oo '- H r— en i H i— ro ιι cM co cn σ. m cM oo [- o r- H m cΛ oo r- ι^ι r- ιⁱ H m σ. oo cD oo H VD en vD i— CN Co i H o o O H O vo ro m cM OO OO r- co ro cM vo io ro i' O i^, m m H O oo o cn cn cD i— cn cM CM m oo ro m i' O i' H oo co r— co m co o m oo co H co o H O r- CM CM O H m cM m ii m '- Oo σi vD r- o in oo o ro H i- vD oo o ro o vD ' c- i' H O H CD _) i- _ι cn cn oo ι- c- θ H i CM cn <n ι r- ' oo r- H vo cn oo H co cM CM cn H ^, o vo co co

Φ ui Φ in •» vo vD r- vo oo r- oo oo oo oo r- io σi en co m ¹ co •- ro r T «. CM ro CM CM co cM o o co ro ro cM in in in co cO H O co co -. H O O CM O O O o o i i i i i I I I I I I I I I I I I I I I I I I 1 1 1 1 1 1 1 1 1 I I I I I I I I I I I I I I I I I I I I ro cD iⁱ oo cM en H iⁱ co i' r- co vo ro co oo i' CM oo cD r- ' co c- vD O H Oo ro ro i σi oo cn iⁱ vo r— m r— H m 00 [- l^, C- O H CM 1^, H 1' CM i- O l <n r- VD CM CM m i' CO OD VO CM OD O lO ' H O T CD CD t— CD m m cM CO H CO CO VO CΛ H Cn H CM CO li (O CO H σi O lD CD O CM r- VO li m H OO H CO CM H m '- rO O CD O CM VO OO

H "_ cn o oo H cn m "- tO H r- cn in io t— H cn oo vo o cD co oo vo o r- fO oD CΛ m σv cD H I> _> O CM _> CM Γ- H CM H oo iⁱ oo r- co cn r- oo vo H m r- cM r- o m cM m co i' c ι^, co ∞ c3 θ o r- vD eo o ci cM c c cM c cM c co c m H θ H CM cn oo cn o H C ro ι^ι c co o ι m cD vo r- vo ^{ι i} ' ", c ι m co ιo c

CM CM CM CM CM CM CM CM CM CM rO CO CM CM CM CM CO CO CO CO CO CO CO CO CO CO eO rO CO CO eO CO CO CO CO CM CM CM in m rθ H CM <n cM CM CM H ^ι en "- H CM cn cn r- r- H c '3^, θ ι— co vD cM cD θ c_ _> -i o cM c_ co r— o co m H t— vo cn H H VD co H O oo oo 'r n o i— o m ^•w CM H oo cn co ιi H H VD o m o co r- vD m ι oo ro o H en r- cn co vD m o o m m oo H cn o o ι^, CD CD Co θ 'r co en r- oo ro i' CM VD m vD ιι oo vD _> ι CM C— VD ιι m <n o •*, r— r— vo vo o r— I' r- i' m t- co o cM oo vD io σi io i r- o ro H n co '-' n r— co H oo m cM '- O VD cM H σi co co o o H m ro H H CM i oo i' co cM CM i' CM O vo <n CM oo r— T en r— cn r— cD co m m cD m m co co in m in in vo vo vo r- vo in oo cn cn en oo co -- to m co m r- ro cM CM H O H CO CO CO CM i co co vo r- vo

I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

ι^ι ιⁱ 'τ ι^ι ι 'r ι ι^ι m m m m m m m m vo co co co cD io t- ι— i— t— r- e— I— r- i— co oo oo oo cD oo oo oD σv a^ en en en en cn o o o o o o O H H H H H H H H H csi

Φ ι^,Φ", Φ"^, Φ^,Φ^, ιΦ^,Φι^,Φ'. Φ^,ΦⁱΦ'»^ιΦ'^j|Φ'Φi^ιΦιⁱΦ'rΦ'rΦι^ιΦιⁱ 'ΦrΦι Φ'i^ιΦι ιΦΦ'r 'Φϊ^, ιΦΦι^,Φι Φι Φ'- ιΦ^,Φι*Φι Φι Φ^,Φι Φ'i^,Φ'ϊ^,ΦⁱΦ"- 'ΦrΦ"- Φι^ιΦι Φι ΦmΦΦφφm mφφmφφmφφmφφφmφlDΦ OQQQQQQQQQQQ Q Q Q Q Q D D Q Q Q Q Q D Q D D Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q _. D Q Q C_ Q Q C_ Q D Q Q Q Q Q Cι Q Q

[_ W W W M W W (-. (_ a. rt (_ C_ D D D D D D D D D EH _; c_ Ct; c_ 0H p_H l_ [_ rl J J J J J J J B B M B B B J rl J hl J J J J hl W MWWWaBB H H H H H CΛ CΛ CΛ CΛ CΛ CΛ O O O O O O O O ΣΣΣΣΣ22>

H CM is r^ H^ HΪ H) H) S S r^ l_l H. ω

H CM H CM IO CM fO CM H CM H H CM

D Q B B B M N S mooQ tt mo tt m o Q ω ω rt m o Q ω υ o z υoooυ zoooooυυzooooo rt o

O O O O O O O O o o o o o w o υo υ < o o o m o z ι^,ι _

o tι

υυ oυ υ υ υ z υυ o υo z ooo ooo o z o υ o υ o z o o o υoo o z υ oo o o o z ooo υυ oozυυoo o υ υ z υ υo υ rt I— ϊ. ro J-_

CΛ s

£ H? n <ιι

CJ o co

PM ( d eo co ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooσoooooo

H H H H H rH rH ri r H H H H H

(lι <ι' o n 1. d lJl ffl <ι' o n ^ι^ » o o ^ l ln ιn (^|ι n n ln ^•1 l- ^ fι n ι^,l fl N l o ιN * » o » O N ιJι ι^,l lIι N l- ^(ι ι "ι^| ln d "l' <Jl ^ N » m B » « n N ^ O O ⁽O r^■ O O ι<) ^ o n B d O ^^• 0 ^ π ^l "Kl o n !| ln B B ιn v ^- M Φ 1^l l M ol d d l φ (N l^,l o o o l(^ ^o ι)ι ln Φ B Pl B ι^,ι « Φ B ι o ln n ιJl 'ι^, ιn r• N ι. » o o o ι. ^^ ll) Φ r• ιnΦ ιJι o ιJl ln ιn Φ (^,l o N o o o o o l H d N Pl * N d o » ιn ln ^l) ln ιl) « » ιn «ι fι n ^ » » Φ Φ Pl l N' « B ιll O B ^ r• ^o ι. <ll o> O lIl B l) ffl m o ^

-\ o ol Φ B « o o N r- B ^ Φ d O r- Φ ιIl « σι Φ ιJ ^ ι»ι Λ Λ ιIι ιn l() " '^ » 1. l N ^ l N ι»ι ^ ^ ι^,1 β ιn 900 Φ Φ N r• d n ιIι o ιn B ι < c cn "- ιⁱ "- c <n H VD H r c ιn ( vo vo o c» H m cM CM θθ H cM m cM CM r- 'i" "- H ro o r- '^ cM co cn m o c oo o θΛ o^ vo ^

^ N ιη ^ ^ a r o^ ln o m ι^ι ιll N '. lJ) m o w N ιo ffl cΛoιΛ ι. « ". m ιn d n ^ H β Φ π d ^ o n Φ Φ N B d O N ll ^ ln '. ^ι o B B ". r-

CM ro ro H θ cn σ^ ιι m vD r- vo r- r- ι- ι- ι- oo c o σ> ιo m m m ro ro ι vo ιo i' CM CM CM ι- oo -. en cn cn oo cn oo oo oo cΛ oo o r- vo vo vD ii co co cM r- r- oo oo oo H ro ro co co co cM CM ro ro ro co co co co co ro ro ro r "- ro co co co co co co co co ro co ro ro ro ro ro ro ro co <o co m co ro co co ro co i ro ro io ro ro co ro co co co co co co in

_⁾ c H H c ¹0 t- r o <n oo oΛ m H c co o 11 H e o cn m oo _l H C_ H CD m _^ -> H 1' 00 c cM co cD H σ> e c c cM ^l co 01• ιo 01' Co r^ cM co co cM m 1• r■ιnιn (J^ Φ ΦlΛΦd^oιI> (NBO BlIl^d^ιn<^oιJι^Ol^oι.NBβo^β(1ι.NOlΛNon ΦO ()»Bσι r■ικcN ^ - ι^ι^ι« l^ ^(. ιω Bc^o^BO^^ )r.df1r■ d dO< d dr"ln1r B dd <ιιN"»σιι») ι Nι!^Mm<Mlnr•

O O O H O HOOOHOHOHH O M CO CM CO H H O O H CO H CM CO I CO CO CO CO CM rO CM CO CM CM CM H H CM CM O H CM O CM CO l in cO CO CO CO in iO lO r- VD I I I I I I I I I I I I I

cj CN M ⁽v^{] (}Ni cj CN^' i^,ι ι ι^γi ^{( (i}n^ϊ) ^ ^ flⁱ fl ^ v "r ^ ιn ιn ι) ιπ ιθ ιθ Φ Φ Φ Φ h ^ B B B rø B B B B σt σι oι oι oι σι σι aι o o o o o m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m io cD io cD io Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ

Q Q D Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q A Q Q Q D Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q C- A Q Q Q Q Q Q

. a D a O B D Λ Λ Λ Λ Λ rt Λ di Oi Oi Oi Oi l- Oi l- I- IlI Oj Λ lϊ D D D D O D O D l- X 0- 0- Q- 0- C_ C-ι C-ι aι ι CH C-ι ⁽-ι a< D D D D D D _) D D S D D D B B B B B B B B B B B B Ii| - til lO Dl iO lll lO Iil li1 B B B B B B B B I. B U B B X - ϊ ϊ i i ϊ w n oi oKn n oi w B B a a B B B B B M ω a w H^ Hl πl H5 H5 Hl Hl Λ CΛ CO Λ rt rt rt rt rt rt rt rt W Λ Λ C ι-l H3 H. H3 Hl Hl Hj Hl EH H EH H H H EH rt rt rt rt rt rt rt rt J J Hl H^ H. Hl H Hl Hl H H HH lJ

H CM H C H CM H CM H CM tt m o a a m o oooooooz υooo „o_.zυrtυoυmυaooozυ ttυo mυo M o moao < moo cQ o a a ft m a o. < m υυooυυozoυoυooz < o υ oo υoo zo ooo o o υ z υυoυ

« ιn l^s B O\ O d ⁽N ^ "- I σi O N m |ⁱ ιn ^ 010 d N n » ιn ^ B Λ O d N n "( lΛ ^ O\ O d M M <l^l ιn Φ t 010 d CN I^,l "l^l u1 _ l^j φ ⁽Il lO ^ | ^ f. (~ |. I^» I^« f. t- lⁱ B B β O IIl B B 'O O ffl in θl (Il (^*l irι 01 IIl (Il lMtl O O O O O O O O O O d d d d d d d d d d N (N (N M N N N

"- 'P iⁱ ' ι 'r "-r ι ' i^, "- ι^, '. 'r 'r^, "- "- ι^ι ι^ι ι^ι i' '^{j| ι} ι^ι ι^ι ι^ι ι^ι ι^{ι ι} ι^ι ι ι ι^, ι ι "-^p m m m m m m m m m

00 co co ro ro ro co ro ro ro co c co co co co ro co co ro ro co co co co co ro ro ro c co co co ro ro co co ro co ro co ro ro co rH ao∑oo∑aoo∑o∑o∑o∑oo∑∑ooao∑∑o∑o∑o∑oo∑∑o∑ooaaoo∑o∑o∑o∑o∑∑oo∑o∑o∑o∑o∑o∑o∑oo∑∑o∑o∑oo∑oooooooooooooooooooooo

O tt tt < < < < < < < < < < < < < < ft < < < tt tt tt tt < < < < < < < < < < ft < tt < < < < < < tt ft ft tt < < 4

υoozooooυoozυυoυυoυzzυυooυυoυoozυoooozυooooozzoυoυooozoυooozooo ro *A e

H cM m o m oo co H H iⁱ in vo f- i- CM ^•- o oo en co ι< o co H vo ro H oo m o cM cn o c coo ccnn o r- oo cM co cM ro cn m oo cn co σi r- m i' eo oo cM oo o oo cM oo cM VD H CJ m co H H cn cM o oo cn cn '- m i¹ CM CM r- o r- co o ⁱ o cM Vo in oo i- vo en oo oo co H m oo oo oo H m en cn i— o cM vo m co oo co oo oo H i m i co m cD in vo cM P. (^l ι cJ ". N ^^ ^ _f^ Φ ". ^ ιn ιfl ^ ^ ^ O ιO ι. ^ rt cη ιπ ^ N Φ 9 ι "- ιO "P lO Φ ^ ^ ^ d "r ^ ^ (ϊ ^ ^^, ^ ( Φ Φ B (Λ "]^{, ■}3^| ι

C r rO <O CO C rθ (01" 1 "- CN CM CM CM CM CM CM rO rO CM CM CM CM CM CM C CM CM C CM eM CM C oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H H H H H H r cM ro co m ro ro oo oo oo m m oo o cn m co cΛ H OO o cM O CΛ H co H CO i— co « ^•* i— ιn ro ιn _. o _. _- α. H θ θo co θ H ιn c_o> ccoo H o o m r- o oo cM O i- cM o co co co co oo oo i m r- cM m r- i— 'i^ι <n ιι r- "- co cM θθ vo vo m vo co co cM H H H r- cM oo m cM io m H io oo c— ^ιn _. __ vo o co co -> cn cc- cn _> -> _> cM in t- i- ro i- r- cM H m c- ^, ι oo cM i^, σ. ι^, oo ro co vo eo ι- oo H ro cM vo m r- r- σi H oo co ro σι o oo _ι r- m _ι _> cn t- cM O O t- H CM CM CM r- VD OO CO CO

CD io m en o cM ro o <n cn oo cM ro ι^, co co ι^, co co co co co cM CM co cM iⁱ CM ' CO CO CO CM rO '. m CM H CM I O CΛ OO O CM fO CM H '- CO in cO CO rO CM H I' .O CM H CM CO H H H H H H H H H H H H H H H H

B lJl B l 'n n n d Φ O Φ o ιn ιIl l "f ^ N' d _ι o ln o^ N n N n ιn N ιn N d ^ o ^ <ι^{, ■}» Φ » ι » '. o β d Φ ^ ι d B !N d N o ^ π ιn ι- d ιn O lrl rl d lll ι n Φ Ol Φ ^l d N ι . ιl^ ιIl N » O r- ^ Φ ιO B N ! ^ (B « o^ ln 9 d » ιIl <^l ( (D O O d ι^,l <ll B _ ^ v n ^ B n d O^ O o ιι1 d n Φ Φ l d d ^ ol ιJl ιn o o » O fl N ^ O ^ι' CJl B [^ι o <ι^, N <r lO N l^ d N τ|^l » n o d ( d π Λ B fl ^■. oo oo r— en cn o o cM co co cn oo oo r— i— r— oo co co oo r- oo σi cD m m '- i' co co oo ci. cn r- o o cn -. -. cn o o cn oo i- oo oo vD m vD i' oo oo c- r- oo oo m i co ro H 'r «- "- co ιo ro ro fθ co co co co co co co co co co ( co co co co co co to co ' i< ro ro ( co «- i' co co co ro co co ro co ro co ro co ro ro co co co ro co in

O l— H CM I OO CM CO CM Γ— co co m cD cO '.' ro '. c— m cD co π m o i' i' H i c vD H CD t ii t— -- vo r— ι— m o co cn cn cM θ oo -• OO VD O CO O Cn H CO lO H CM e oo o c c o "- I- o H "- Oo O H < vo co H cM ^O ( O H H H α ", c-l OO ^- <- H ^- o oo <Λ ro cn oo o^ cn H V01100 co <n m ιo ι o ι* r— r— m co cn m co ro CM θ ro t- oo <Λ o r- H H i |— ∞ c ii oo ii oo iO H m H cn o oo cM o c M i— r- O H CM O c_ H O oo r- ori o cM H H m m o ρ- o vo en eo o cn cM CΛ co cn ex- -^ oo m m m vθ "-r m co ι^ι m m r— t— iⁱ co cM H O co cn o o en cn r- cn i— oo r- H CM " i' ro <M vo io m vo m oo σi o o en cn r- cn H CM rO 'r ro m cM ro cM H

H H H H H H H H H CM CM H H H H CM CM CM CM CM CM CM CM CM CM

o o o d d d d d d ddN^l N NcN ι^l N (NNn π n ι mnnnnn ι^l » <ι^ι •»•» <^•J^| ιOlIl ιnlll ln lnln lO Φ ΦΦ ^ ^ ^ BBB Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ ΦΦ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ lO lO lO lO lp iO lO lO lO VD VD VD VO VO VO VO VO VO VO VO VO VD VO VO lD lO lD lD VD lD lO lO lO VO VO VO VO VO VO CO Vø VO VO VO VD VO VD VO VO VO VO lO lO lO lO lO lO lO lO lO lO lO VO

Q a Q Q Q Q Q Q Q Q Q Q Q Q Q D Q Q Q Q Q Q Q Q Q Q Q Q Q Q D Q Q Q Q Q Q Q Q Q QQQQQQDQQQQQQQDQQDQQQQQ

D D D B Λ ft Bi ft iii i- Λ n io w M w n n w n a B w a w w w u w ω ω Λ Λ iii iii i- iϊ Z Z Z Z Zz Zz Zz z ω ω c_ (_ _ ω w ω c_ (i;os « (_ _ DDD D ω ω W -_ CΛ CΛ W CΛ CΛ CΛ CΛ rH H >H H . . >H < >H X X B B X X X B B B a ω W ω _l C_ ω CΛ CΛ CΛ W CΛ CΛ -. rt H H H M H H H H CΛ CΛ CΛ CO CΛ -Q O O O O

H CM H CM H CM H CM ooυa aozo ttooomυoQoQ rt moaωc. tt m o a a ω w N rt .. C zoυooυoυzzυooυυυυυυυzυo mo < m H υooaooM H CM ooozooo zzo ttoo mooυoυDυ z tυtoo mυ oozυ ttoo Ol O d N ιη fl ln Φ ^ B Cs ^ ^ B B β B B B B m ιn m m m m m m m m

oS oS o2 o r 2 o-i £ o 8 28 8 28282 S3 S3 S3 S3 S ft3 S3 S rt3 S rt3 S f3t S tt3 S f3t

ATOM 3590 CB GLU D 668 24.870 34.424 11.971 1.00 38.03 c

ATOM 3591 CG GLU D 668 25.628 35.126 13.108 1.00 44.35 C

ATOM 3592 CD GLU D 668 25.293 34.587 14.486 1.00 48.70 C

ATOM 3593 OEl GLU D 668 24.088 34.510 14.817 1.00 51.51 o

ATOM 3594 oε2 GLU D 668 26.237 34.253 15.243 1.00 49.33 o

ATOM 3595 N GLY D 669 22.655 32.418 11.526 1.00 31.97 N

ATOM 3596 CA GLY D 669 21.967 31.179 11.860 1.00 32.06 C

ATOM 3597 C GLY D 669 20.536 31.057 11.364 1.00 32.25 C

ATOM 3598 o GLY D 669 20.025 31.933 10.665 1.00 33.15 o

ATOM 3599 N LEU D 670 19.890 29.956 11.742 1.00 33.75 N

ATOM 3600 CA LEU D 670 18.504 29.657 11.368 1.00 32.29 C

ATOM 3601 C LEU D 670 17.562 30.800 11.776 1.00 30.44 C

ATOM 3602 o LEU D 670 17.341 31.042 12.974 1.00 30.45 o

ATOM 3603 CB LEU D 670 18.061 28.363 12.058 1.00 35.46 C

ATOM 3604 CG LEU D 670 16.981 27.492 11.395 1.00 37.43 C

ATOM 3605 CDl LEU D 670 16.490 26.458 12.406 1.00 37.83 C

ATOM 3606 CD2 LEU D 670 15.826 28.346 10.919 1.00 40.46 C

ATOM 3607 N SER D 671 17.001 31.482 10.778 1.00 25.84 N

ATOM 3608 CA SER D 671 16.094 32.615 11.007 1.00 23.68 C

ATOM 3609 C SER D 671 14.693 32.368 10.446 1.00 23.41 C

ATOM 3610 o SER D 671 14.529 32.194 9.236 1.00 21.63 o

ATOM 3611 CB SER D 671 16.675 33.871 10.356 1.00 23.21 C

ATOM 3612 OG SER D 671 15.746 34.934 10.338 1.00 25.59 o

ATOM 3613 N ASN D 672 13.689 32.349 11.320 1.00 21.36 N

ATOM 3614 CA ASN D 672 12.308 32.143 10.875 1.00 22.35 C

ATOM 3615 C ASN D 672 11.912 33.258 9.902 1.00 22.21 C

ATOM 3616 o ASN D 672 11.157 33.032 8.950 1.00 24.69 o

ATOM 3617 CB ASN D 672 11.337 32.149 12.065 1.00 20.58 c

ATOM 3618 CG ASN D 672 11.329 30.833 12.837 1.00 21.92 c

ATOM 3619 ODl ASN D 672 12.025 29.886 12.480 1.00 19.61 o

ATOM 3620 ND2 ASN D 672 10.534 30.776 13.908 1.00 17.38 N

ATOM 3621 N TYR D 673 12.432 34.456 10.145 1.00 21.48 N

ATOM 3622 CA TYR D 673 12.149 35.619 9.304 1.00 21.97 C

ATOM 3623 C TYR D 673 12.655 35.459 7.864 1.00 21.83 C

ATOM 3624 o TYR D 673 11.902 35.648 6.903 1.00 20.20 o

ATOM 3625 CB TYR D 673 12.784 36.886 9.904 1.00 23.46 C

ATOM 3626 CG TYR D 673 12.445 38.150 9.131 1.00 26.59 C

ATOM 3627 CDl TYR D 673 11.410 38.985 9.543 1.00 26.58 C

ATOM 3628 CD2 TYR D 673 13.081 38.442 7.920 1.00 30.47 C

ATOM 3629 cεi TYR D 673 11.005 40.066 8.768 1.00 28.11 C

ATOM 3630 cε2 TYR D 673 12.679 39.522 7.134 1.00 28.23 C

ATOM 3631 CZ TYR D 673 11.639 40.322 7.565 1.00 27.76 C

ATOM 3632 OH TYR D 673 11.205 41.353 6.771 1.00 30.64 o

ATOM 3633 N SER D 674 13.929 35.121 7.701 1.00 22.90 N

ATOM 3634 CA SER D 674 14.463 34.997 6.352 1.00 25.20 C

ATOM 3635 C SER D 674 13.767 33.896 5.585 1.00 24.29 C

ATOM 3636 0 SER D 674 13.400 34.080 4.425 1.00 25.42 o

ATOM 3637 CB SER D 674 15.985 34.779 6.373 1.00 26.07 C

ATOM 3638 OG SER D 674 16.352 33.749 7.265 1.00 33.54 o

ATOM 3639 N ILE D 675 13.568 32.753 6.227 1.00 23.44 N

ATOM 3640 CA iLε D 675 12.878 31.653 5.558 1.00 25.04 C

ATOM 3641 C iLε D 675 11.495 32.101 5.075 1.00 23.96 C

ATOM 3642 o ILE D 675 11.128 31.875 3.924 1.00 24.31 o

ATOM 3643 CB ILE D 675 12.701 30.456 6.493 1.00 26.81 C

ATOM 3644 CGI ILE D 675 14.068 29.859 6.822 1.00 27.96 C

ATOM 3645 CG2 ILE D 675 11.794 29.421 5.849 1.00 29.47 C

ATOM 3646 CDl ILE D 675 14.017 28.844 7.936 1.00 31.50 C

ATOM 3647 N ILE D 676 10.738 32.749 5.949 1.00 24.69 N

ATOM 3648 CA ILE D 676 9.406 33.209 5.581 1.00 26.76 C

ATOM 3649 C ILE D 676 9.490 34.244 4.466 1.00 28.81 C

ATOM 3650 o ILE D 676 8.621 34.297 3.595 1.00 28.83 o

ATOM 3651 CB ILE D 676 8.677 33.815 6.811 1.00 26.99 C

ATOM 3652 CGI ILE D 676 8.440 32.719 ^■ 7.858 1.00 22.68 C ooz oo oo o oo zo oooυo o zz o υ oυυυozoυoυυυzυυoυυo zzυυoooυυzooo oϋ ϋz oυoυυ

o cn cn oo CM m m cn m r- <Λ H ffl _ ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo co en in αo m cM io -. o i' H θ θ ι co cM θ CM ro i" VD m <n H CM i cn r- ro H i- [- oo m oo m c θθ [- oo vo m co 00 O I— T T CO OO T CM VO O l' i' CO CM i— VD H oo m oo vD σ. cΛ CM i' iD co m . σ-i r .- i— H .. -. oo cM CM H OO H Co H CM cri o i— cn cn co o o cn m H Oo oo i— 1 c— cD H io m vD m r— m σi i o o oo oo r— ro t— n ro H f i o o oo o oo io oo ir—- CCMM oOoo <cnn een CcMM H Co H t— H o^ σi cM C D co cM H CΛ H i i vD VD r- m i— i— H i r- co o co oo ro oo o r- m t- oo o ro en ii CM CM cn rO CM H CO CO CM CM CM O O O O H H H O O O H CM H CO O O H H H O CM H CO CM H H H co •- m 1- CO CM CM ro •- f in CM H CO ID r- CM I 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ιo r- vo en ιι m vo cn cM CΛ CM H H CM H cM θ cD cn θ 'r vo r- oo H H Oo ^| ro o <M <n cn r- cM m vo co H r— cn ro o vo cM o o cM O t— ι< r- τ oo co ' i^ι ι ιn H io r- _CM m oo m vD O H CM m in in co oo r- r— T CO H I— ( iD H c_ r- σι m en cM <rι m m m oo _> en H CM ∞ c 'i^, vD CM CM c» ^ι σι o oo vo ro cn co cM CM VD co co co cn o. i cM O O i en o ro cn r— co vo cM f co i H H cn m H CM H m o r— co m oo cM i— <n ii r- od ι d fl ^ι' n r' π pι ιn " ffl (N ( Kl ^ O (^ι (Il Φ » ι>^ o •» O

^. ι1l ιn ln ιn ^ B ffl » n n n N (N m n ιnN ι n n o m ffl » ln n u ^ Φ ιn Φ ln ιn Φ ^ ^ n ι ι l d O d O fl M '^ "^ n 1^ (N l Φ ^ co ω (O ro co co co co co co co co co co co co co ro co co co co co co co co ro cM CM co co ro i ro c co co co co co co co ro co co co r^ in vo m r- c cn Hπ i en r- c m H r- oo 'r m cN T H CM O CM vo iO H H oo cM i— cn m o H r— oo '- oo o cM co m cn oo i cn cn cM m co m H r— vo H o vo oo o iO 'i' i- t m cn ii (N Φ ^ O ιn Φ d ln ^ n B β ^ N O Φ l/l ^ (^ d N ι o Φ d ιll m t" m r• o ol ιrι lO ι^,l n B Cι d l ιn N ^ Φ ι^ι « ιn Φ ι^,l r• ι^,l Φ W ln Φ Φ co t- in ^ ol "f m B ^ _ ιn(N' ^ (^l ( ιn B '. Φ o ^ B N m Φ B m Φ <n n (^ι CN « r- N ln « O d _ N ι») <!l » Λ d ^f O Φ W '. ^

C- I- o o o o d d ι^ι O o o ι ι l r• αl r• ^ ^■• ^•-• (I\ ^ r• Φ r• ^O φφ Φ B Ol B β O O N »ι B ^ Φ » r_' O r• Φ ^". f fl * N ln "^ "^ 1' ln »

H H H H

ΩΩΩΩ ΩΩΩΩΩ Ω ΩΩΩ ΩΩΩΩΩΩΩΩΩΩ Ω Ω Ω Ω ΩΩ Ω Ω Ω ΩΩΩ QQQQQQ Q Q Q Q Q Q DQQ D DQQQDQ Q D Q DDD

C_ C_ aι C_ C C_ θLι C-ι αι O CΛ CΛ CΛ CΛ CΛ CO CΛ CΛ CΛ D D D D D D D D Hl Hl

- - n o) B i w n w n >ι >ι >! ι >! > >ι ι ι iιi ιa B ω iii w a iιi ι< 3 oo tt m o a o rt m o Q W N tt m oα α tt o o z oo o o o o o z oooo oo o z z oυ oo o oo z o o o m oo o o m QQ tt mooo tt moo < mo z < o o o ooozzooooooozoooooozooooυ o d l v «l d d d d H Γ— t— Γ— r— Γ— t— oo aa∑ o∑oo∑∑o∑o∑o∑ooaoaoaaoao∑o∑o∑o∑o∑o∑o∑o∑oaoaoaoaoao∑o∑o∑o∑ ∑o ∑

O ooo∑o∑ oo∑o∑o∑∑oo∑∑o∑o∑oaooao∑o∑o∑∑o∑oo∑ o∑oo∑o∑∑o∑o∑o∑ooaaoaooaao H EH H H EH H H H H H EH H H EH EH H H -H H EH H EH EH EH EH H H EH EH EH H EH H EH H EH EH EH EH EH EH

O ft < tt < < tt < < < < < < ft < tt tt < < tt ft < < < tt < < < < < < < ft < < < < < ft < ft ft < < < < < ft tt < ft < tt tt <

o o z υoo o o oo z oo ooo o υ z oo o o o υ z υ υ o υ oo o o z υ υ o υwz oooooo z υ υ o υυυoz zoo o o o o rt r- , ro fM β CΛ S

H en r- o (- oo co m co m cn cM o H CO Ii OO CM H CO OO H m H CM O O CJ o co co m vo H cn cM cn r- o tM O vo cn en vD co H co cn r- co co m

PM o cn co m vo i— c— vo oo r- m ι^, i' m vD r- oo cΛ co H H H θ oo r— Γ— vo r— r— t— r— r— Γ— Γ— t— r— cn cn cn cn cn cn cΛ cn cn cn cn cn cΛ co co ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

HHHH HHHHHHHHH HHHHHHHHHHHH ro CM o m H vo cM H m i' H CM CM ro o vo vo σi cM in co eo co co co i' ro cM m r- H co H 1- 00 H M H CO CM I' CM CM CO VO T CM H CO r- CM H in cn cO i- CO H lO r- CM H r— cn oo oooo oo m i CM t— oo H CΛ co m r— CM i* co ro m ι σι r— vθ H <n c— H OO OO c— r- o CM i^, cM i^, oo m -^ι o oo oo ι- cΛ o cM r- oo θ ι- r- ι- - o σi ι- ^ι m oo

CM co oo CM o oo o o ro oo o o Φ Φ Ol d d V O OKIl lO ll N O O rN O CO H CM T ". "- co r- CM H VO i io H H CD H i- oi m H co ro co H r- co ro r- oo

^l N β <l\ O ^ B B <J o ^ ^ B B lΛ O Φ ιn m o !! ( N N d ^ι <^l (^,l n "^ "l "l^| o>l (V! N M O O O ^ι c » 'l^| C^' l N N » Φ ^ r^■

I I I I I H I I I I I I I H I I I I I I I H I I I I H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

« B ( lIl r• ι^,l B O t^ <ι^, d lll n d (ι ^• d ι^,) ιn Φ ιn ι^,l d ^ι B O N ^ O d(>ι ιll ln ι^,) d n o o d ιn ιIι N ^ r- ιΛ N B Ol n d N N <n "^^, N d ai θ n (_N N W « IO Φ M ( M N B B N n ιn θ Φ N β m "f <r Φ ( ( d O d d "l' ^ ^ (N P- d Φ O ιn ιn B [N («) <n θ O> ιn B n <^l N "f N 01 m r- O Cn H CO CM O CM 1' H C CM O H H H m H H Cn cθ O <n H CM O r O CM H m iO ι- O CM CM CΛ Oθ r- VO V0001^, 1i H 01' '- CM '- <_i "- 001i |- CD OO CM Cn ιι m r- en vo m m m vD c— m i c i 'r cM H o o vD CD r— i— r— vo r- oo r- ∞ oo c θΛ θ3 θ VD m "- co cM m t— [— m ι cD _^ σ> o o H M c τ co oo r- oo r- t- vo ro co co co co e co ro co ro rη r^r) co eo co eo co eo co ro co co co ro ro co co co co ro ro r^ co ro co ro ro ro ro in σι ιJ O Λ "l' B n B O O Φ ιn Φ o σl N O l ln ιJι O Φ B O l '» Ol d ^ B _ CN N ^ B "l^, ιJl "ι^, lπ ^ ^ c^ll «1 ^ι^, r- ^ ιIι N ιIl Φ n (N ^ (Jι B lfl ^ o ι»l t » ( ^ ^o d ^f ^^ » o B ι»ι » φ αι « B B N O Φ ( ^- (l ffl ι Φ o o κ^ι 5lΛ o ι») 1> o n o r• ln M ln B ιl Φ ^ n ^ ^ f^ d ln B N ri B Φ ^" ιn l ι^,l Φ (N ι^,l B B d o ^nM O O o » r• N Φ (^ ^ N O ιn n B ι«ι c^l "f O ( N N d Φ O (Λ ^ O N ^ o σl ^ n ln ^ o

T ii vo i r— oo oo cn ii co cM H co ii rO T CM H H O H o H CM CM CM H VD r- CO CM H o o CM CM O H CM co CM CO H H CM H CM H H CM CM _"- o o H CM

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

m m m m m m m m vD VD vo _ι _> _> _ι _> r- ι- t- r- ι- r- r- oo oo cD e_ ∞ ∞ eo e» oo -ϊ cn c^

CO CO CO CO C_ 000300 Cfi CO 00030000000300 ro 000O CO CO C„ C_ _) C_ ∞ α> O0 G00003 C0 CO CO 0000 ιo vo Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ

Q Q Q " Q - Q - Q - Q - Q - Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q

D D D D D D D n n U W tt Ui a a a fi < ft ft < ft < rl ^ l l >4 >4 4 X X X X X X rt ft tt f tt ft rt«ι; <ι:«ι;(i;(i;<<:f< «; j iHjιjiHHij μι>> >> >: >>ooooooooooooooo>>>>>> o o o o o o o ft ffl U O Q ft moDQ < moo tt m o Q ω ω tt m o < m oo tt m o α ω - O O Z υ υ o o o o o υυooυυozυυoυυυ zoooυυυooz oooυcΛz o ooooo zυ υo υo υ υ z3 z o ft o m o o υ

Φ r_' l)! Ol O d N n <l' K) Φ B ιJ^ O d ^ι n •^' lfl ^ B lI\ O d lM n ^ ιn Φ o D> o l n <ϊ ι β ι>l O d N n ^ l ^ φ Φ O d ( n "» Λ ^■ H H H H CM C CM CM CM C CM CM CM CM c c r r r co c r r c ι "- τ ']i ι i 'r ι ι ι m m m m vD io ιo v ιo co co vD VD VD c— r— c— r- r— r— r— r— r— i — — i — t- r- r- r- r- r- r- r- r- r- i- r- r- r- r- r- r- r- r- r- r- i— c-- t~ c~ t^ ι~ ι~ ι~ ι~ ι-- t~ r- r— r- r- r- ι-- r— r- t~ t-- t-- r-- c-- r~ r— r- t-- r- c— c— r— r- r— r— r- r— r— r- so ro co co eo co co co co co ro co co eo co eo co co co ro co co co ro ro co co ro ro . ro co co

222a∑aaaaaaaaa22∑22∑ © oooooooooooooooooooo oo o o o H H E-J tt tt < tt < < < < tt tt < tt < < < < < < < tt < <

oozooooυozzυυoυozυoooozoooozυoooooozoooυυoozoooozυooozoooozoυoυ

co vo oo r- r- H m CM o o 11 co vo m i— vo cn vO '. co -' oo cM CM cn m ii i— oo cM r— H Γ— ιi [— oo oo cD co oo σi r— m cn o i' σi co vo vD ro oo cn oo

VD H ιι vo co vo cn cn t— m o H m en -i I' co co oo σϊ in vo cn o io oo r— co cM co vo cD o σ^ cn o vD oo H ' CM CO co ro co oo m i' vo i— oo oo r— <n VO I- CM CM CM CM H H H O CM C '- 1^, CO CM en oθ r- r- 00 oo oo cn cn cn cn cn en cn cn cn cn cn _N cn cn α Φ θMπ cA oooooooooooooooo ooooo oooooooooooooooo ooooooooooo o oo ooooo

HHHHHHHHHH HHHHHHHHHHHHH

CD CO VD lO CO 00 r- d ι-• B _ n n ^ d 0 ^ι^ι π ln α) O d ^ιι d ιιl (Jl B ^• Λ O » 5l O * ^■■ ι l r• t• n ι ^■« B ι»ι Φ ι»l d d d O\ O n ιll O O N ^ Ol m O «* r- CD VD 00 H CM o m m cM vo cM CM Oo cM ro en oo r— cn cM O CM H CΛ H CM vo o i oo t— O H m en i< <n ii vo H O H co r- oo cM CM O io co co i vo t— ro co r— cn oo IM o ^ ι ιι oo m vo H ^, o r- cn ^ι en <n H CD CM Co H _ι ro oo H θθ θΛ CD _> ι- ro r- m c '. CD r- m cM CM θ cn o m en o θ 'r r- r- vo co vo cχj o co ro ιo o r- oo co vD co ι- vo r- m vo vD CD CD co co oo o o o H θ H H H H co cn en [- ιo co co r- CΛ r- vo m m co m m vθ "- ro H H CM H H θ θ H co r- vo m r- vo ' i^ι ι^ι m

H H H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM H H H H H H H H H H H H H H H H H H H H H H H H H H I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I O M' ι β ι <n 1|' ι^,) "r n in

CM co cM m r- ro cn iⁱ o m H r— co H vo t— en m cM r- CM H i— φ ro co cM r- vo i— o r— i— C θ r- o τ r- H o m cM m t— m H H co o o cM H H CM '- H r- H O r— cn vo co cM H Vo o co H o m vD o cM H cn cM τ τ σ> o σι vo H m r- ^, cM CM r- ∞ r- en H ^ι en cD CD co o H r- co cn ι- H θ co <n H _ι m m i' CD H r- ι^, ro m H co cM _ι oι n n ^ ^ ιn » o fl ^ ιIι n d ^ Φ ffl ^ l0 ^ 0l Φ B n * N H lIl ln ^ N^, o ιn o (n '^ » ^p) » lι ^ o ^ ^■ n N Ol (Λ N ιn N » lIl o r• f| l!l Ol (I) ll^ m co ¹ m r- 1" in vo co r- oo oo cn oo co oo oo oo vo vo r- O O O Cn cM CO CO l- H O H H mcMco ' _'ini' ' ro co co *- co

I 1 1 1 1 1 I I I I I I I I I I I I I H H H I rH rH rH rH rH rH ri ri I rH rH ri ri rH ri ri rH rH ri rH ri I I I I I I I I I I I I I I I I I I I I I I I

N o _[-

DQ Q Q QQQ Q Q QQQ QQ Q Q Q Q QQ QQQQQQQ QQQQQQQQQQQQ QDQ Q Q Q QQQ Q D Q a Q Q QOaQQQQ QQ

D D Z Z Z Z Z Z Z Z - I- Λ Pi lϊ Λ Λ K H Λ PC Λ W W >J ιJ CΛ Λ C CΛ 0 Λ Λ ω ω C_ ω ω M ω ω ω ω t-i ω H >H O O rt rt rt rt rt rt rt rt W CΛ OT CΛ CΛ CΛ CΛ CΛ CΛ ω CΛ CΛ ^j Hl ω w rt m o Q Q ft m O Q Q ft m Q Q < m o o z o o o o o z z o rt o o m oo o So m o rt m o υ o z υυ oo O O O O O O O Z O O O O O O O m rt o υ o υ z o o m o υ o o υ z o o o o cn o H CM co ^•» . l _n. Φ ^ ^• ιJ^ o d M f^ 1» ιn r- m ol O d N ι^»ι ^ ln Φ B lJl O d N ι^»ι ^ ln r• ιJl O d N n "l' ln ^o r- B ιJl O d ( ι^,ι « ιn σl O d r- co oo oo oo oooo oooo oe_o ∞ oo o3 CΛ m ^ cn ^ <n en en cn cn o o o o o o o o o θ H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM co co eo co ro co co co co ro i ". i- r- i- r- c- r ^- p^- i- ^ ^ ^ r- ι-- ^ ^ <n ω β o) oo αl » m ι-) co m m B co co » » ω B oo ω ω ι^ι B co ω B B B αJ B B CO B B B o ra α> σ)

00 ro ro co ro ro co co co ro ro ro ro ro ro ro co co co io ro ro ro io co co co co co ro ro ro ro ro ro ro e^ VO

222222 ∑ 22222222 a 2 a a 2 a a a 22222222222 a a 2222 a a a 222222222 ∑ ∑ 222222 ε a a

O o o o o o o o o o o o o oo o o o o o o o o o oo o o o o o oooo o o o o o o o o o oo o o o oo o o o o o o o o o o o o o

O 3δ3S35SSS5S3533S rt

z o o o υ z o υ o o o z υ o o o o υ z υ υ oυoo o o zo υ o υ o υ z υυo o o υ z υ z z z υo o υ υ υ o z υ o o o ϋ o o o o r- ro JM is

© β -3

H r- H _> m en o co cM CM θ r- H CM oo r- ι o co vo en ι— <n o o cn en ^ι r- τ m o oo H VD θ H cM CΛ H CΛ t— oo c VO H Oo m H iⁱ H O CΛ O H rO CM in CO CJ <n m ιJι N N φ 1» ιn ιIl (Jl Oι o Φ n » ^ N B ι^,l O ι^ cN ι>l B τ o (Il ln m N ^ w <J Φ ^ B <Jl ιΛ O '* "r ( ^ ^^» o^ ln 1i (Tl C0 1 O "-r VD li VD

PM ιn c H H ro oo m cM co τ cM «n vo ιι ιι vo r- oo H r- ro cM O CM m "- m vo H O io r- oo oo io co cM oo cM io cn H ro H H en vo m oo en cn cn rO H cn t— en cn cn cn cn oo oo oo oo oo oo r— r— i— c— r- r- r- r- vD io Φ r- r- r- c- r- m m m m m m ^{ι ,} ι ιι i' m m m co cD CD co co co co co co co co co cM CM co co co co co co

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

o N n d d r- d N Ol M Φ O ι ιΛ ιΛ vo H Ii li OO CM ιono McM πcnι t— i—

I I I I I I ιη ^» ffl <r φ ^ N ^ d Φ oι ln Φ ιn Φ ^ ^^ ol ^^ ^ ^ n d Λ «) rl lJ) ^ ( <ι^, o Φ Φ oι ^ ιn r> d Φ N n B N ln d l ^•■ Φ o o » Φ o ιIl N ( cM H r- vo o vo co oo H m cn m cM H CD co o r- <-» vD H ro oo en co oo co (i) co co m cn cD i^ι o ι^ι σ* o co o cM vo H m m H m co oo ι- r- i" i" H θ H oo H H i ι^ι r- co cM H CM T t— m m H CM O CM co vD in m oo r— r- cΛ r- _> <n m cn o cΛ r- m ι i' σ< i' o '* ro <n H <n oo ιn co co cs] in i' θ o ιn en o o o co r- ι— t— oo o vo o vo ro n ^^p ιn Φ n 1l' ln » 1» Φ ^ 'ι^, n n 1» n n v w ^ι ι d O d ιJι n n ( N « ι) l'1 d o o o ιl ι- ι-• Φ ιn ll 9 lIl αι ^ 5ι o d N Φ Φ ^ Φ Φ Φ l O ln CM co co co ro ro ro ro co co co co co co ro ro co co co co co co co ro co ro co cM ro ro ro co c^ in eM θ c H r- * CM cn co ι oo ro co vD o ro ιo o iD CM m co cM io * co o o vo cM en cn cn oo r— m ⁱ o ii o σ^ r r— m r— I OI CM O H T O O Γ— r— T * T H CM H n r^> n B ^ B ( Φ r• l ln n ol C B Φ ln n o ι^,l n o (ll d 01 <Il ^^ o ιn ol ιn ^•-• o ι»ι v ι>l Φ B v M d o ιIl '^^| ιJι « d ^> ι^,10 r- σl cΛ _ ⁽η θ N Φ ⁽Λ "^p r" i Φ B ^ ι^τ) v r" h m ιn fl» oi d d iη Φ θ B iθ Λ Φ <Λ ^ ιθ ι d ι r" (i ι) fli ^ Pl Φ ( ιπ cft o o m ιi fn d M θ r θ in io vo m oo vo m i in vD i— co cM CM CM H H CM co ro cM H "_ vo t- m cM O O H O H CM cn cn oo i— O H H H H H O OO Γ- VD C— Γ— t— oo r— in T co cM T in co in c- vo rH ri rH rH τ-H rH rH rH ri rH ri ri rH rH ri rH rH rH rH rH rH ri rH rH rH ri ri ri ri ri rH rH ri rH \ I I I H H H H H H H I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

co co ro co co i T iⁱ T i in i in in i i i i vo D o vD vo vo o vo r— r— r— r— r— oo oo oo oo oo oo oo oo oo oo oo cn cn cn cn en en cn cn o o o o o o o o o o

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O H H H H H H H H H H r- c- r- i- r- r- r- c— r— r— r- r— r— t— t— r- r- r— r- r— r— r— r- r- c— r- r- c- c— t— t— r— r— t— r— r— r- r— r— r— r- r— r— r— :— r— r— r- r— r- r— r- t— r- r— c— r- r- t— t— r— r— r-

^{Q Q} Q Q Q D ^Q Q O ^{Q Q Q} D Q a Q Q Q Q Q Q Q Q Q Q O Q Q Q Q D Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q D Q Q Q Q Q Q

X x x x x _; x β; o5 c^ήgg g g g g gDD D PD D D D D q o o o o o o q o q q q o o o o o oDθ D D DD D D ω ω ω ω ω ω w ω w ω H-l μι rl oo o c o< ci iiι Λ i^ . rt rt rt rt rt rt rt rt rt rt rt HJ H3 H3 ιj 3.-q H3 ιJ fiι Ci. ι^ c o. fc cij Ciι βι θ

H CM

< H CM H CM H CM H CM z o o o o tt m o Q m o Q t_ ω rt m o o tt — o o o rt „ ooozoooooozoo m.O_ .^Q_ _M N B X ft mOQ Q ft n U ^{Q Q} B-rB, o o o o o o z o o o o o o z o o o o -- o-- o-- z- O Z ZZOOOOOOOZOOOOO OOOO

o z o o o υ o o z υ υ o o o o z υ υ o υ υ o o o z υ o o υ υ υ o o z υ o o o υ o o υ υ υ z o o o o o υ o o o o z o υ o υ υ υ z

© ⁱ a ©

£Λ

H en H CM CO T r- H CM CM H ι- _> ι m en ιι r- CM H r- o o CΛ ro r H r- cn H θo ∞ c "- ι- co r- H r- cn cM θ co '- CM r- - oo ro H i' θ io i' σι co o O " H O U «- H CM CO CΛ r- O CM 'T H CM O O H co ro m cD oo io r- H ' r- r- m cn ro m m cM o co m cM ro ro o cn cM o o t- oo cM cn r- m cM cn cM H H co T H ro P. co cn r- vo m vo ii m vo co oo cM co co cn cM H CM i' H o m en o o cn oo o ι— ιi '- H co cM CM H io cM i m oo σι o θ H en <n σ> σι o CM CD m m σι cM co oo rO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CO rO CO rO lⁱ i* i¹ co co ro CM CM CO <O CO rO 1^, CM CM CM CM CM CM CM CM CM CM CM CM CM CM r0 CM CM H H H H CM rO CO CO CO CO 1 1^, 1 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

r- o cM O r- cM '- vo m m H r— vo m iO H i' en cM CD ro r- r- H r- 'r in m o vo cM i— o r— o vo o vo H O CM T CM en ro i iD CM r- en m r- o iD r— iri H vo m o co oo r— co vo co vo D i o r- H _CD cii o r— o^ vo σ^ ι H C θ r- c θ vo co o cn o c o "- oo o r- ι ι— CM m cM o co r— CΛ H CΛ H H m ro m co cM H i r— " H H

Φ _d _ B Φ Φ M_^ N ( N O O lN Kl B d U B d d O O Φ Pl N M d lIl B O ιn i » lllB IO r- B Φ N B fl C N d N d B d ιnCN B mB Φ B t" K) ιn MO d

Φ N _N o π ( » _{N d} O Ol N n π o O B ^ d d ( N N <Λ Φ B <ll d d d ιn v ^ Φ lO ιι1 ι ιn Φ ιn <> ι«ι ιn ιl) ^ ι r- lι ιo <^ n( d 1f ι^,) '!' ιn ιo oo ro cn o ι H m σι ιι vD CD i CM Vo r- i' i' en m H <n cM co '. cn o H en cM CM CM 'r <n en m m vD co co cM Vo m H 'r co co vo cg co cn <-o ι co m co t- o i' CM τ

^ ^ o ιD ι^,) n 5l ι- « « B <ι^ι Φ O Φ B O ^•" ^) O N » ιn ffl <Il Φ ln » ιn ln r• ol co « Φ κl B d d c ^ t^|) d Φ o « o ^ o ( O « o - oo ^ι ro ro co <n oo o3 m vo ι^ι m r- m ^ cM θ o oo oo r- m m vo ro co m "- H CM ι— o vo oo m oo o cM H m ro vo m o r- m co o ι <-^ r- cM vo co ι H t— T H H o

Φ ι ι ιfl ι ι n N n ιA ιn « « ιn Φ ιn n N N o ol o B l N n n N n N n « ιn ιn ιn B ιn α o n o 4 4 n n v Φ Φ Φ B l H N o ιl1 B l8

CM CM CM CM CM CM CM CM Ol CM CM CM CM CM CM CM CM CM CM CM H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CO CM CO CM CM CM C^ in

O CM CO H CΛ rO cn iO H VO I— T CM m i O i— t— m H H C H CM 1i cn m eo vo m co m c— en cn o iD oo en o _ cM . c.- c -n m_. c -M. i-Ti C..M -. _'-i i in co cn H Λ o σi -— co co en cn H r— H oo H m m o vo eo cn o H OD r— H c ιn ιn ι* ι^, uϊ θ_i '1r iC umι \_ii> _ι V_Oι ιι _ϊ HH τ1 u_*1i ti—- ri-li rr—- moo moo roroj ^Tp rCMo rr—- CoOo o in r- cM co r- oo vo oo o co o H m o r- vo cΛ r- cn i— m ιo < ιi H iι ιι ιi [— cn en i H co oo oo r— H C vo m cM m cM H H ' VD ". i— ro cn o cn en r- co co oo oo co H r- vo oo m cM H CM i CM

I— CO H O O H CM O H H H CM CM H H H O O O H H CM O O H H CM cO CO I' m i' H H O O O O H O O O O H H CM CO CO rO I' l' l l' O O O O O O H CM I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

θ H H H H H H H CM CM CM CM C C CM r r ro ιo ro n r r 'r ι^ι ι «- i ι ι ι ι m m vD io vD VD iD CD VD D VD D θ [— r— r— r- r— r- r-

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H r— r— P— r— r~-r~r~t^r—ι— r~r— r— r~-t— r— r-t— r— ~ι— r--r~ r~r~t-- r~ r~r--r--r~r-c~ι--t--r^,-r--r~t--r--r~ι~r--r- ι--r--ι~- ι^{^}— r—r- r-r~r--p-r-r~r-- r-- r— r— r— r—r~

QQQQQQ QQQQQ QQ ODOQQQQQQ Q QQ Q Q αQαQQQQQQQ QQ QQQQQQQQ Qα QQ Q QQ D Q Q Q Q Q Q QQ ω tfr;α. -;« « «OOOOOOODDDDDDDDD D DD D DD DDDωMωω

X a a B B X X X X X Cu 0u l-: BJ X j HH H^ HH l-l HH lJ HH HH Hl J J H5 H3 HH HH lJ X X X a X X X X X X X X X X X X PCj « «

Qι EH H EH EH H Eπ H _< Λ _ι _j c_ Λ _< e) o o o o o o o o o o _ι αι CM C c αι _j αι θι Pj fe αι αι iiι C

H CM H CM H CM H CM H CM H CM H CM

N tt m o o < m o o rt m o o. ω ω ft m o Q ω ω tt m α α ω w N t IQ U Q Q B B N tt m o α w υ z υ υ o o o υ z o o o υ o o z o υ o o o o o o z o υ o υ υ υ o o z o υ o o o o o o o υ z o o o o o o υ υ υ υ z o υ o υ υ υ z

υzzzυυoυυυozoooυooυυoυzoυoυooz zoυoooυzozzzυυoυozυυooooozυooϋooo

H o oo 01 CΛ O VO ^•_ ID H H H O H CM r- ro ' cn io H m H cn m vo cM VD co o i' H en cn o o r- cn cn ii H m cM CM cM m o cM co i- vo cD H o r- oo H cn H m vo H CJ «, CD O O CM CD -. VO r- H 1" CM m m r- CO io cn i o vo m cn o m oo -^ m r- ( i^, i' m co r- H H H H i' en H ^, H o o cM CM H ro cn i cn ii m m m co o oo o cM

PM

O OO H VO CO CM CM CM CM H O l< 1 VO CO CM CM CM Cn H CM H OO O CM CD H co i- m ' oo o H O i' O co ii m ro cM m r- r— ii i o i' r- r- ro i' C '- O i' vo vD io oo cΛ cn m τ ιn co co (o ro ro co ro <o ro ro eo ro ro co ro cM ro ro co co ι ι ro ι* τ ι^, ι^, ι^, τ m m m m co ιo vo vD VD m m m m m vo vo vD vo vD VD io co c— t— r- r- r- r- r— t—

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

«- I- H O ι o ιn pi Φ » ιn ιn β n o i" d i^,ι o ιr) βi Φ N θ if) ι β N B fi » t" θ> » Φ i Λ θ ifl i^,) β o n β B βι » « N (π ι^,ι i- ιo o ιθ B n o r' » ^

H oo in H 01 B d B N » CTι r Λ lfl ιn ri B l B IIl O O <l' d Φ N Φ n B » » 01 « IIl O Φ Φ d d d B ll) O Φ B C O ιn (1 IΛ MM O tN N d l) 01 <J r- [- CM H H CM O cn vo oi m αj H O O o co r- H O i' o m i m r- ro H CΛ co H H H co '. i' oo O H H ro io i' ro m m cM oo r- σ'i o cn σi oo vD VD io vo oo H H O O in m vO CO CM H O CM CO H i H H O H CM H O H O O O O O H CM O H H O H CM CM CM CM ro m cM co ro T m r- co cM '- co in vO i— oo io t— i I I I I I I I I I I I I I I I I I I I I I I I I I I o oo vD co r- c» cn Λ r- oo o> m ro oo o m oo ι^, o co H vo m m o vo m cM CM ro τ m <n o vD ι r- vo <M <o m τ τ cD CD f io oo o o vD '. ιⁱ H co m oo o H m ro

» n β ιo ιo » d β » Φ β » Φ d n « » o B ^ β d ιn ^ B « N n ιn » n n « d m » β o ^ ^ Λ ιr) N O H ιι) ι^,l (^,l H lι) N « o ι<ι n ι (^,ι cvl ⁽Λ Φ ιn o ^β Φ ^ ^ ιlι Φ N O W Φ ^ n Φ w » O ^ ^β Λ N * « Φ r^, Φ ^l p^■ N ι^,1 ^βι * 0 o « N ^■J ιn ^β m n w d O * Φ Φ ^^■ * N N Λ t-^• in r- vo oo ro ro i^, i^, i^, ro m 'r m co m m vo r- oo _> a> r— oo Hr ro cM CM H CM H co cM H CM CM H o cn oo co vo io co m m m vD r— m i m m r- vo oo ro cM CM CM H O cn cn

H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H H H H H CM CM CM CM CM C CM CM CM CM CM CM CM in Φ O ι^ι vD en N « n C0 CM l

^ ^ ^ B B ω B β Φ Ol » <>ι ιn ol σι Jl (l\ m ol lJl O O O O O O o o d d d d d d d ^ι ^l N ^ι ^ι <^ι n (1 π n ι^,l ^l ι^,l » « « "l^, " « ι^l •» d d d d d d d d d d d ri d d d d d d d d d d N N M N W N N N N N N N N N I N N N C t N N N N CN N N N N N N N N N N N N CN N N CN r— r- r- t— r- r- r— c— r- r— r- r— i— r— r- r- t— r- i— r- r- i— r— r— ι— r— r— i— r— i— i— i— ι— r- r- r- t— i— r- t— e— t— i— i— r- r— i— r- r— r- i— r— r— t— r— r— r-

Q D Q Q Q Q Q Q Q Q Q Q Q Q Q D Q Q Q Q D Q Q Q Q Q Q Q Q Q Q a Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q a D Q Q Q D Q Q Q Q Q Q oo ωωωωωωωwwwωωωωωωωωωzzzzzzzzo o

K Λ X H Hq Hl j Hl J H^ Hq X X X X X X X a X C CΛ W OT C CΛ OT tΛ S oή Cή OC K OCi OtJ X rt X rt rt rt H H rH H H rH H H CH C C Cij c c^ oj Λ αi CH i-j rt rt rt rt rt rt rt rt rt rt rt rt rt rt rt rt rt rt rt r M

- HH rCMl H rCMo _Hι — H I rCM πH rCMo _ Hj CMvi _ H-ι rCMo — Hj /CvMi H i i o o NXzXzzooo moooooQoz totooomoooQoQowowoNzo ttooomoooozαzortooomoooαzωoNzxzazo ttooomoozo ttooomoooooαzo ftooom - o .. CM oo o a ao owo e_n^,

_- ^φ01 oo co co rH rH 22 Σ 22 Σ Σ 222222222 Σ Σ 22 Σ Σ 22 Σ Σ 222 Σ Σ 222 O ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

Eι tι h h E-: H Eι H h E-: Eι h H H H h H h EH H Eι ι ^ H tι ^ H h h h ^ H tι ^ H tι H H h H H E< ^ h h e4 H Eι h h E-: Eι H H H E< H Eι E< tι

O ft ft < < tt tt ft < < < < tt < tt < < < < < < < < tt < < < < ft < < ft < tt tt < < tt < tt tt ft < ft ft ft fi < ft < ft ft <

z oooozoooooooυooz ooooo o ozzo oooooozυooυυooooozυooooυzυooooozooo rt r- ro -Si

JM

H co σi oD CM CM CD cn ⁱ r— m cM m ' o ro cM i e i' o m CΛ in co CO σ> H 00 vo CD CM H ro r- r- cn VO -• cn O in ID en H cn X in 00 ro cn 00 O cn en m ro H r- i r- m ' i' r- cn co H cn vo oo oo r- cn ιo CM CM O o r- m 1- t- _"- ro CO o m M C- C U CM ro H CO O r- en VO o en r- o CM o CM 00 in CO cn CM ro CO O cn cn 00 «- PM en ci m i c oo cM i' in ro i^{i i} i in r- o CM CO ro ro m _> I- r- r- oo cn 00 00 o o H en en cn en cn o en H CM co CO ro co CM ro ro ro ro CM ro CM CM CM CM t— oo oo oo oo oo cn cn cn cn cn cn cn cn ai cn cn o o o o o O O O o o o o o o o o O H H H σ o o o o H o H H H H H H H H H H H H H H H H H H ri rH ri H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H oooooooooooooooooooo O o O O o o o O o o o O O o o o o O O O O o O O o o O O O O O O O O O O O o O O O O oooooooooooooooooooo O o o O o o o o o o o o O o o O o O o o o o O o o o O O O O O O O O O O O o O O O O

H H H H co co _> _ι co r- m cM oo ^ι cθ 'r vD r- co m o cn <M θθ CM m r- co σi H CM ro en co oo ro H m m co o cM vo r- ro cn H CM Cθ H H OO CM CΛ CM lM H O CO I' Cn iO VO li VO oo oo r- cn o m o vo H oo cM io o t— H m oo i vD VD r- O H r- cM CM m H CM <n m oo _> r- r- ic i c 1o*1 ui o _o/ c iioi c -n1 o _ι H n CM i un# cM in' 00 CO CM co cn CM Λ r— VO CM ^*- CO 1" r— o cD θo crι o τ co ro ι CM ro oo o m _ι o o H <n co τ cΛ cn m cM CSι m cn r— rO H H CM iⁱ C CDO OO CCMM rroo rr—- oO ccnn ccMM vVoO cCoO cCMM OO CM OO CM CΛ CO cn H O H OO O r- r- co ι— m m o H CD cn en cn o o o o H CM CM O cn co r- r- cM ro co co cM CM co H co co ' m ro ro cM CM '- co in r- co en t— en vo i— r- co σι r- t— r- o <n <n oo

I I I I I I H H I I I I H H H H H H H H I I I I rH rH ri ri rH rH ri rH ri rH rH rH rH rH rH H H H H H H H H H H H H H H H H H CM H H H I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I n m Φ ^ N ιJl o^ d d <ϊ O ι^,l (N <^ (l ( o\ c O ιo (^l "» β <^,^ ^Λ d 0 ^ι o^ o o B ln ^ n o r• N B c^,l ^^ Ol O d 'l B n ^•» ^ ι) O d N ^■l^l vD vo o iⁱ c r- CM Vo io t- T H ro o i— o m cM cO H OO CΛ m o i— H H i o cD ro H H io r- O c i— r- m ro cM H oo vD r- H m o H m τ co H θ VD θo cn en ιι cM

O d ι N * n « ^ » oι » ln β ^ ι1 H Φ oι N ^ n n o d O ^•^ ι » o d « β fl ^^ d » B ^ * » n β Λ β ^• o d O lIl ^| r• N « <n fl l (Λ _ n n » 'r n ιn Φ Φ i> (n « o o d ιn » n n fi » ι ι <^, r <ι^ι (^rι * n N θ θ ιr) ιn r- B <n 5i o o Φ B x ιn * n N » <ιi φ (») i»ι n rι

CM CM CM CM CM CM CM CM CM CM CM CM CM ro rO cO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ in ι- VD r- oo m r- oo m oD _i "-p vo r- m H H Vθ o vo cM i' o en oo o σι ro cM ro σ cM CM co _> r- m _> m m co ro H _> "_ V0 C0 CM r- CM CΛ ' CM CΛ O O 00 CM H H C0 _3 co H CM CM H o m αo vo o o T i— ro r- cn cn en cM o m H O Vo i— m cM ro H en oo ⁱ oo m m o cn vD oo T i— r f^ rH-ι «nι o_. vc τH-ι .r-, ιi-- vo i- Hι ιH-ι -m, co σi oo vD cN cn r- cM H O CM CM co r- r- m rΛ m r- m o o ro o H O H H H O CM O O H O CΛ H cn H i- r- i- cn H oo cM cn H CM -i vo vo o — vD en vo ⁱ H ^• m r-

O O O O O O H O H O CM CO CM CO m CD I- 00 H O H O H H H O C CM CO H CM Ii CM in co m rM CM H H CO rO rO O O O O H CM CM OO CO O I I I I I I I I I I I I I I I I I I I I I I I I I I I H

in m in m in vo io vD vo vo vo vo vo vo vD vo r— t— r- r- r- r- r- i— r- oo oo oo oo oo oo oo oo cn cΛ cn en <n cn σι en cn cn cn o o o o o σ o H H H H H H H CM CM CM CM

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CO rO rO CO CO CO CO rO CO CO CO CO rO CO CO rO rO rO r- r- r- r- r- i- r- r- t- t- r- r- t- r- r- r- r- t- r- tr—- rr—- rr-- ir—- ii—- r— r- r— t— c— r— i— I— t— r— r— t— t— r- i— t— r- r- t— r- r- r— r— t— r- t— r— t— t— r— r- r- r— t— r— t— r— r- α Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q α Q Q Q Q Q D Q D rt (< (⁽ < (5 B B B W a w iB B a a »i ra in »i w co w w o) (ii iij Cii ft »i Mi₁ pi_< a B 6) B a a B rl rl rl rl M lJ μi lj rl ^ Hl Hl lH rl ^j H J J > a a x a a x a a a a a xX xX xX x x x X xX xX x. — — ^~ X X ^{~~ ~}X X X X X X X X ft tt ft tt tt , tt tt < (*i p« 0i Oi Ui Oi Ol Pi dl Oi Oi J J rl Hl < tt < ft ft tt tt < > > > > > > > > tt tt <

. . CM H CM H CM H CM H CM H CM H CM rt m ft B U Q Q H Id N ft H O O B N ft m O Q Q < m Q Q W M N zoooυzoυoυooυυυozoυooooozz oυoυooozυυoυυoooυo < m o rt m o tt o o o o o υ z υ o oooozυoo oo en o H . C .M . co τ m vo r .— ro _ cΛ O_ H C.M. rroo iι'ι imn ivoo !ι—— oooo eenn θθ HH CCMM rroo ττ mm vvoo rr-- c_ en o H CM co -^, m VD r— oo en o H CM co iⁱ vo r- oo σi O H CM ro ro τ ι^{, ,} ι^, 'r ι ι ι^, τ m m m m m m m m vD VD VD VD VD VD VD Vo O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O

∑2∑∑2∑22∑∑∑∑∑2∑∑∑∑∑∑222222aa oooooooooooooooooooooooooooo ft tt < < tt < tt < tt < < tt < < < < tt < tt tt < ft < tt

o o o o z o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o

vo τ m co cM CM CM θ co τ ιo ιo τ H ro o cM τ H ro tn H cn H CM vo 1 CO H CΛ 11 ID ii r- vo •. m H in r— ιn ιo τ τ cM τ ιn o cM r- vo eo cM co co oo ιo _> 1 cn co o oo os σ^ r— r— r— H CO I- H in m oo T oo in co H O oo r— co o r- m vo cn co m m co m m vD VD i— o o i m m o i— m oo o oo vo vo t— r— m cM CM ro i— ro H ro o o cM H i— H r— c- o o co vo ro ro m r- i CM CM lO lO VD VO VO VO VO VO H CM CM CM CM CM CM CM CM CO CO CM CO CM CM CM CO CO T T CO T rθ τ rO CO CM rθ CM T T CO ro m τ τ ro ro eo cM co τ ro ooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooo cn oo C i vo iⁱ o ro cM vO H i— ro t— co t— r— H t- vo o r- vo O T H m m o vo co r- ro vD CD en o vo H o o cM ro o o r- r- cn en o cM CΛ o o co r- co cn H CM T lD VD H CO T H CO H rO lO m CD T H OO m CM CM CM H θo cn τ cM VD Co τ oo o en ι- t- ro cM r- co co oo τ r- oo oo cM ro oo m ro i- H oo m cn cn H r- vo

T r- σi T m vo H oo H i- vD ro m i- m cM H oo ⁱ c H oo co o m oo co vo m oo vo r- oo cM oo oo ro io m oo cM oo H r- r- cM ro VD r- 0 τ en H cn r- o o en

00 H co oo cM co r- oo vo r- m i— r— vo vD o m cM t— o i— m cn cM m H t— m cn τ σι co ι— m ro en τ vo ιo τ oo m co ro σι m H H en vD oo τ co

H H T CM ro I I I I I I I I H H CM CO ro H CM CO T CM H rO CM H T CM CM H CM d H CM T I CM CM CM H H CM CO I I m co co cn o cn en cM ro cn i— H H o cn m cM cn ιo τ o <Λ cD ι— τ cn cM _ι _⁾ H τ -^ co m H H co vD τ cM CM τ m o vo vo co cn cM H θ r— t— vo H co cM o H O CM co io ro T i— ιo m τ cn m co m co m cM m ro o r- τ τ o vo cM co en cD θ oo o t— O T T ro en cn en co cn H m σi cM T t— m cM cn H O H r- cn H VD θ ro σι m -> -n ro τ en _> θ H en ro ιn τ θ ro ιn oo o r— H co ro ro o i— <n oo τ co σι en τ r— o τ en en vo en cM τ H τ o ιo cn vo co τ c— r-

1> CM o co m co oo i— i— en cn co io o o oo i— t— H T Vo co cM m cM m cn m oo r- o m H H i— r- T O t- T CM VD ro m cM CM r- H CΛ O cM oo cΛ cn o cM Vo σv m CM CM CM vo τ τ ιo ro m co co co ro n τ ro cM ro ιn τ cM τ τ ιn co cM Vθ τ co cM τ τ τ co co cM τ cM τ τ cM co cM co τ τ ιo τ τ co τ ro ro ro vo cM io co ro m in CM O CM CM CM CO O O OO m OO O H T CD VD CO OO OO O m cO VO r- CO T OO T T O O m CM OO H O O O O T CO r- O H CO H CM I- m O VD OO CM O H r- OO H H en oo H CM in co o cn oo oo co m m in r- o ιn cn cn τ t- o cn co ι- ιo eN ro o cM in -> -> o co ιn <n o cM CM r- ιn m oo oo vo co τ cM CΛ r- ιn vD ro cM H H Co ιn oo n n ^ "l^, 'f B O l M ( 0 » n ιn ^ ιJl Φ ^ Φ 9 N ιlι ι^l d « ln ( ll^ B N ιll (^ι ^ d ιn ln N P) ιι1 P1 N d (ι n ol N Ol B O lrι r- CO CM T CO O m CM H CM CO H cM rO rO OO m oO CD m CM m CΛ CO m CΛ OO H r- cn oo cM -i cM CM cn O CM r- m σi vo σ> cM vo o co cΛ CM co co vo τ ι— o I H CO CM H CO H H H H H H H H H CO H H CM CM CM I H T H CM CM H H fO CM CM H CM CO rO CM H CM CM CO CM I

CM CM d ι m » ln Φ ^ ^ ^ r• ^ ^ ^ d N n 'l^, lll <ι ι» O d ^ι n » ln » oo ιll O (^ι n ^^l Λ Φ t> lD lll O N n * Λ «! ^ ιB Ol O H N n » Φ co ro o o o o o o o o o o o o o o H H H H H H H H CM CM CM CM CM CM CM CM CM CM co co co co co co co co ro co τ τ τ τ τ τ τ τ τ τ m m m m m m r- t— O B O m B B B B B B B B B B B OO B B B B B B B CO DO B B B OO m B B B B B B B O B B B B B B B B B B B B B B B B B B B B B

Q Q o υ

Σ Σ Σ Σ rt rt OT CΛ Co rΛ CΛ CΛ CΛ CΛ X B B B B X B X X rt. 3E 3 SQ ZC 33 33 S 33 33 33 33 33 33 33 33 33 33 S 33 33 3»i 3. 33 EC

OT OT co co o o « , o- PH (-; a; , (_ o o o o o o o O O O O O O a O O aO a aO xO aO O O O O O O O O O O O O O O O O O O O O O O O O O EH H H EH EH H EH EH a a a a B x a a a a a a a X 33 2G _C 33 _C H S X lS rC rC X l K rC X r-l X rC K υ Σ Σ Σ Σ rt rt O O O O Z O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O CΛ CΛ CΛ CΛ O OOOOOOOOOOOOO

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O

m o o r-^■ <n o T ro ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H H H H H HH H H H

O T CM τT oOoO τT ιinn ecnn τT ccoo oo HH ιinn cooD cCMM CCMM ιinn oooo ιinn oo τ H θ en H CM CM ι- 0 co cM T co vo vo io co co r— ro H i— H O CM cn co vD oo cM m o co cn cM m oo T CM i— o o vo HH <nn ooDo imn ιn ccoθ HH ccnn c_n'ι ccMM ccnn oooo ccMM VVDo θoDo σen*ι oo cn o o τ T c cnn τ c roo τ T c mΛ H H m vD H c i- c m cM cM m vo T cn H vo m io vo r- o en c oo ro c vo T r CvMι ι COn ι VOn r I-- r 0r0. ri m m θ CM H OO H r- VO C- σ» T H oo r- r- ro oo o o C CMM τ ro H m eo H vo r- r- en H co co oo H θ CM CM CM r- r- CM m m τ m τ _i ro oo co co ro r- vo m σi ro m cM O O i— oo i— O - r.— vo cM co r— τ r- r- τ ι— H σcn> τ . c .o . o .o. oo τ cM cn ro τ ro ro cM m ro ro cM r- θ H t- 1- H ro co

H H CO CM CO H T CM H H H I H CO H CO T H CM H H m CM CM H H H H H H CM CO rO HH CCOO CCMM in cO H T CM H CM rO H CO H T T H H I CM CO CM H

I I ro cM co m ro oo T H CM O CM Oo co o m oo oo H CM O cn en - r- φ » o ιn (Jι ιr) σι r^« d ( n ιn Φ io » B θ r- ιθ θ CN » o ^ B n i N (N !ii Φ i^ d _ r- c- vo H τ en oo vD ro ro m r— H in cM oo cO H m H CO r- H i— τ m ιo m iD <o ro co τ vo τ oo o co ιo cM H r— T co o t— τ τ τ m cM τ en H τ m oo cn vo oo cn r- o o o <n vo vD θ H vo m m H H co ro oo H r- cM vo r- H O Cn r- m cM CO H OO O CO H Cn cM m oO O CO CM H CM VO m co m H VO CM CM H CO VO OO CO CM O T m H H VO

00

O T CO CM H H T CO T VD CO O O O H m r- VD T T CO H O m VO H oo cn cn oo ro H m τ H m <n H CΛ T r- oo oo m oo oo H CΛ Vo o ι- oo σ» cM oo r- cn H co i- vo cM VD τ vD cM VD ιn τ ιn vo τ vo τ cM ro vo ro ro τ ιn τ cM in H T CO H m ro ro m cO T CM T CM ro o H (O rO H lO m CM CM CO VO CM CM CM m CM H H T CO m cn c CMM τ θ H m τ τ vo m m co o τ co t— cM r- oo oo <n <n τ oo co o m co co H m r— m o H τ oo oo cΛ en cD co τ co co τ τ cM θo σ> τ ro cM en τ τ cM r— ro en o T cn

CM H r- T Oo oo vD σi cM CΛ CΛ o m T OO oo o ro m T Oo ro H T CM cn co i— r— τ H io cn en ιo cN en co cn vD ro o co o e_ τ r- H CM io vo m cM CM O vo H m H o T τ o o τ m cD CM CM m co cΛ i— ro o cM r— vo co T CM O m H oo —i en o oo m m r- cM τ τ en ι— ι— m en ιn τ τ _> <n o co en ι- ro o io i— ro in oo en r- T or- ιn ιn _> ιn ιnco H o VD r- ro ro T vo CM T co en T CM CM CM

CM CM 1 H CM CO CM CM CO CO ro CM

en o H CM τ m vD r- co cΛ θ H CM co τ vo r— oo cn o H CM T in vo t— oo cn o H CM CO T in io t— oo <n θ H CM ro τ ιn vo t- oo α θ H CM ro τ ιn _> ι— co <-N θ H CM ro ιn φ l⁽ι ιo φ ^⁽ φ ιlι ^ ^ ^ ^ ^ ^ [. ^ ^ ^(|) |I) |I⁾ ιIι ^•D J) lIι ⁽D B Ol Ol lJl ιll ιIl Ol lIl ⁽Il 0^ ι^ o o o o o o o o o o H d H H H ri d N ^ι l ( ⁾ CS C0 C_ C_' ro 0D C C_> GO CD C_ C_' C_ _) C_ C_ c_. C0 CO G0 00 0- 00 O3 00 00 00 00 O3 O3 00 00 CO 00 00 0D xxxxaaaaaaaaasxxxxaxxxxxxxxx

OOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOO O O O O O O O O O O O O O O O O

XXXBBBBBBXXXXBBXXXBXXXXXXXXX

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

laoi t

HETATM 4217 o HOH 924 17.587 59.642 39.191 1.00 43.12 0

HETATM 4218 o HOH 925 22.812 24.637 9.520 1.00 46.83 0

HETATM 4219 o HOH 926 22.586 61.146 9.839 1.00 30.25 0

HETATM 4220 o HOH 927 20.143 20.685 34.805 1.00 32.86 0

HETATM 4221 o HOH 928 -0.129 30.047 26.719 1.00 41.23 0

HETATM 4222 o HOH 929 18.693 64.441 43.617 1.00 26.18 0

HETATM 4223 o HOH 930 3.316 26.782 31.229 1.00 30.65 o

HETATM 4224 o HOH 931 8.782 41.756 37.184 1.00 38.10 o

HETATM 4225 o HOH 932 26.815 65.475 31.026 1.00 37.12 o

HETATM 4226 o HOH 933 8.096 48.366 22.796 1.00 45.13 o

HETATM 4227 o HOH 934 4.661 27.558 28.897 1.00 33.72 o

HETATM 4228 o HOH 935 40.351 55.087 47.376 1.00 47.23 o

HETATM 4229 o HOH 936 7.950 32.677 47.497 1.00 39.88 o

HETATM 4230 o HOH 937 12.548 44.676 21.718 1.00 34.89 o

HETATM 4231 o HOH 938 -8.820 40.219 1.469 1.00 49.47 o

HETATM 4232 o HOH 939 7.489 53.321 8.112 1.00 49.45 o

HETATM 4233 o HOH 940 19.944 39.180 44.418 1.00 45.27 o

HETATM 4234 o HOH 941 29.508 64.292 41.649 1.00 47.23 o

HETATM 4235 o HOH 942 47.050 56.585 38.269 1.00 50.59 o

HETATM 4236 o HOH 943 7.616 45.571 21.859 1.00 39.67 o

HETATM 4237 o HOH 944 7.909 44.216 26.286 1.00 48.09 o

HETATM 4238 o HOH 945 30.114 47.882 12.560 1.00 44.31 o

HETATM 4239 o HOH 946 2.782 22.874 35.242 1.00 41.79 o

HETATM 4240 o HOH 947 16.770 62.683 36.910 1.00 41.79 o

CONECT 6 661

CONECT 300 1042

CONECT 661 6

CONECT 1042 300

CONECT 1068 1738

CONECT 1377 2103

CONECT 1738 1068

CONECT 2097 4097

CONECT 2103 1377

CONECT 2388 3114

CONECT 3114 2388

CONECT 4097 2097

CONECT 4101 4102 4103 4104 4105

CONECT 4102 4101 4106

CONECT 4103 4101 4107

CONECT 4104 4101 4108

CONECT 4105 4101

CONECT 4106 4102

CONECT 4107 4103

CONECT 4108 4104

MASTER 385 0 7 19 6 4236 20 44

Table^'6^'

Table 6 FGF2 / FGFRl / Heparin Ternary Complex

REMARK coordinates from simulated annealing refinement REMARK refinement resolution: 25.0 - 3.0 A REMARK starting r= 0.2340 free_r= 0.2850 REMARK final r= 0.2310 free_r= 0.2893 REMARK rmsd bonds= 0.008843 rmsd angles= 1.48262 REMARK a_initial= 5.38223 wa_dynamics= 5.24774 wa_final= 5.67599 REMARK target= mlf md-method= cartesian annealing schedule= slowcool REMARK starting temperature= 2500 total md steps= 100 * 50 REMARK sg= P4(l)2(l)2 a= 98.888 b= 98.888 c= 196.292 alpha= 90 beta= 90 gamma= 90 REMARK parameter file CNS_TOPPAR:protein_rep.param REMARK parameter file CNS_TOPPAR: dna-rna . param REMARK parameter file CNS_TOPPAR: ater_rep . aram REMARK parameter file CNS_TOPPAR: ion .param REMARK parameter file hexa . param REMARK molecular structure file: deca2_8.mtf REMARK input coordinates: deca2_8XB.pdb REMARK reflection file= 23bdec2.hklt REMARK ncs= restrain ncs file= ncs.def REMARK B-correction resolution: 6.0 - 3.0 REMARK initial B-factor correction applied to fobs : REMARK Bll= -10.663 B22= -10.663 B33= 21.325 REMARK B12= 0.000 B13= 0.000 B23= 0.000 REMARK B-factor correction applied to coordinate array B: -1.815 REMARK bulk solvent: density level= 0.295271 e/A 3, B-factor= 10 A^Λ2 REMARK reflections with I Fobs | /sigma_F < 0.0 rejected REMARK reflections with | Fobs | > 10000 * rms(Fobs) rejected

REMARK theoretical total number of refl. in resol. range: 20197 ( 100.0 % ) REMARK number of unobserved reflections (no entry or |F|=0) 1892 ( 9.4 % ) REMARK number of reflections rejected: 0 ( 0.0 % ) REMARK total number of reflections used: 18305 ( 90.6 % ) REMARK number of reflections in working set: 17419 ( 86.2 % ) REMARK number of reflections in test set: 886 ( 4.4 % )

CRYST1 98.888 98.888 196.292 90.00 90.00 90.00 P 41 21 2 REMARK FILENAME="deca2_8XBA_l.pdb"

REMARK DATE:26-Jun-00 16:58:39 created by user:, moham ad REMARK VERSION: 0.5

tH C- O VO OO r- iH O c vo cM in c r- D OD n T r- ro r- τ <n ιf) H Vθ ro r- ro vo m ∞ r- co ιn ro τ co H cn t— o τ cM oo r-ι ro τ CM ι-i ι-ι τ oo ιo co vD ro cM o r- ιn τ o c>ι o ιr> CM r rH θ cn o o oo r^» co o o rH in vo ro cM iH o r- τ ro ro ro τ ro ro oo cM _ι-ι CM τ iri in in in v in in i' ij 'j¹ in m m T T T T •oi ro ro ro ro ro ro ro ro ro ro ro ro ro ooooooooooooo oooooooooooooooooooooo ooooooooooooo oooooooooooooooooooooo

(ι ■« n oo o w n m ιn oo 9 ^ (^ι m o ^ c!l H ω ^ ^ l co ω ol ι^^ O fl Λ n o m o ffl C)l ^ <Λ ^o ιo ιn ω o oo ιn rl r N O N ^ Φ ιo ^ Λ ^^ ^O ri ffl H m ^ lrι n ιn N H ^ ffl ^ ^ ιrι ιn ^ Λ O H ^■» m cD N H ('ι o ιn ι ^l) H O ln l) ft ^ ^ o o (D O ^ ('ι oo ( Ol ιn ι'ι o o ι ιn -τ t- 1-^ D θ co r- H D ro iΛ H C θ ιn H Vo τ c CM H c c cn cN θo cn cM r- H ^ cM iΛ co o c co vo τ ι cn ω ^ oo w ^ ιJl ^ n ln ln l ^ ιn ω ω ^ ^ ω ω ^ n ιn ^ w M ιη ^^ N (η ^ u^ ιn H ri o o m ω m oo o ^ ^B ^ ω ra o o ιn ^ ^ n f^ c ro ro co ro n co co n co ro m ro ro ro ro ro m ro m n ro n ro c m ro ro m co n m ro r^

H H H H H H H H H H H H H H H H H H H ιH ιH H H H H ιH rH H H H H H H H H H H H H H H H H H H H rH H ιH H H ιH r--I H

∞ vo cM iH r- r- H o r t oo c c o r- T .H CM σi r- r- in in c in in 'T VO iH ir) -i iH C r- r io cM ri '- r- r- o ^' CM tH oo m rH IT) O rH rH rH ι ^ O C^ fπ ri r r^- m oo « T H r. ιo « Ti Fi--!l HrH nO NCM HiH riH nO ιVOo mCn ιr —- rr—- . in T _ι T oo cM τ σι o cM ιH in o co o ro ro oo vo r- oo ro oo ι-i rH T r- r- oo rH r- τ r- rx> co ro cn _> o cM m cTi T CM CM O m o m oo ro r- r- co T T iO T i— o n co o ^' CO Ti ^i oo oo r- r o r— T CM o cn ro in cn o

O Λ CΛ OI Oa αi ω lΛ O ft h ^ in ^ ^ in fl in ^ h W ω ffl ^ Λ O H N N N N H Λ H f H N N H rl O O Φ Ol r- W H O H H I -J r CM CM CM CM CM CM CM CO C CM CM C C>l CM CM CM CM CM CM CM C\] C C C CM CO rθ r r

O CM •«_ O VO T CM Γ- O OO OO Γ- Γ- v M' ιn n ω ^ « 1 Λ ιn H c^ι σl co n oo N ιn N u^ ω (l H c r-- o ^ ι w c^l ^B ^ ω r-^• N « '<ι^, r-^■ (ι ro CO CM O τ o m ιr) τ^ι cM r D τ <» ιrι ιo (Jl O H ^ι Λ o ^ cM ffl co ffl v ^ ^ ln N to ol Φ 01ι o ^O f') H ^β ιn w _ _ ^ '» o w o ι_ c) in ro CM σ T co o ro o ro cM O CM ro τ H CD ι o ^ (O H N O^ N oo ^ o) co O N N '» o <» ιn ^l) r- Ol O^ H O « ^ (^|1 ιo ^ ^ ιfl ^|J3 ffl O lfl ^

Λ ω ω ^ - r- Λ Ol H O Ol <D ) ^ ιs ^ ιn ^ ι w » « ^ ^ ^ ιη ιn ιn ^ ιD ω w » ιn ^ ιn '^ PO ^ (D ^ tD Ol Ol O O τ-^ co ^ o o o

CD VO VO VO VO VO VD CO r— r— lO lO VO VO VO VO VO VO VD VO VO VD VO VO VO VD VO VO VO VO VO VO VD VO VO VO VO VO VQ VO VO VO VO VO VO r— r— r— vo vo vo r— f—

ω ω u} ω v> v) U) Vi ∞ θH Ciι P cu θj <j θH θ θ θ θ θ O O w v) w w ∞ tn u) '3 θ U) is rH M H M rH a a a a a a X X X X X X X X X Vi w w w ui uϊ w υi ςύ oZ cύ ςύ cύ ςύ & x x x x cύ oi cύ cύ

X S I X S S X X S I Dι l- l- llι l>ι (lι

CM H H CM H CM m u D D ω ω tt fid eQ O Q Q ω ω t. ff) _> Q Q Q tζ m _> o o υ o υ C t U U r- u z u o z u υυoυυoυaυ o z CJ υ o o o z υ u c υ υ o z tt co o a ω . oυυυυzuo z υ υQ υ

00 rH H rH SSoSoSo2oSoSoSo2oSo2oSoSoSoo2oS2o2oSoSooSΣoSooSSo2ooSoSSoSoSoSoSo2oSoSoSoSoSooS2 O o oo2o2oSoSSoo2oSoSΣoΣoSoSo_o o f ft ft rt fZ fi ft tZ fZ fZ tt f f tZ tζ fZ fζ eZ fZ ft r ft ft fll ft ft f ^

ro fe . ι N H 0i o ^ cι o ι/) θ <ι^, 7 iΛ r^» r^ι ri in ι. o Φ in o ιn o i^ι ιr> ι r θ rH co _> ro o H cθ Lθ cN r cM in o *. r- r-ι r- ιr) r- r-4 i ) θ cM θ n r o ε_ & σi r- io pno co f ω cKη i- ir ri H - a in m o W N O r- H - ^ co M CM iH c r o r- oi in o oo vo in o o vo ∞ r^ r- vo cNi H 'r in r oo c r r o co oo in co o r- vo r- ro ro cvi cM rH CM O o cM r-i rH Csi ro ro ro T ^r vo co -T i iH σi cn o cri o cM f CM C rH H O o r T r r cM iH O O β ro ro T T CM CM CM C C H H H CM C CM CM CM CM CM CM CNI CM CNI CM CM CM CM CM CM CM CM CM CM CM H rH CM H CM CM CM CM CM CM CM CM CM CM CM CM C CM CM CM CM CM ooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H ooooooooooooooooooooooooooooooooooooooooooooooooooooooooo U

PH rH H H iH H H H iH H H H H ri H H H H H rl co oo co r— ro <— i ιn cN) r- H ιH cτι co (» iΛ oo T r- o o co r- i in r o UO O rH O

CM ro τ ro ιo ro CM T IT) ID

CM CM CM CM CM CM rH rH rH H

H O ∞ ιn

T CO ΓO Γ- (^,l r^ n <J ι H H 1» ιo o m ('ι m co r- r- r- o o m oo w » ιn ιn ιn ιn ro ro _ θ H N H ri r-ι ro ro r co r co ro c c vo oι r ιn cN θ o ∞ vo in ιn ιn o r- r τ τ H co ιn ^ c>ι _> _"> ∞ vo τ H e7ϊ τ ro

H C r- vo o cn r- ιn σ\ ιn ιn co τ o cn ro ro r- ιo CN ro ro τ σ> o c_ι ro c_ι cNi vo c» τ H ( c ^ ^ H *τ csι ιn CO ιn oo o <Λ -τ c» r- vo τ vo o r H τ σi vo co vo oo o H CD Cτι o cNj csι o c_^ ιn -J r (-^ cM a3 C n ^ H vo c τ o o o O O i-H o H O O C rH CM rH r ^j^ι ιr) vo co σi co r- n o m vo τ Ln τ ιr) Vθ r- r— _ β\ H cvi f ^ m o «) ω r- oo en r- oo r- cn oo oo oo oo r— vo r- r- r- f- r- r- r- r- r— r- co r- r- r- ^ ^ r- r^• co ^ r- ιr--- r- ^r-• ^r- ^r- i— ^ r- rr-• ωco ocoo ωco ωco ^r- ccDo ^r- ^r- ^r--- r- r- ^ r- ^r- rt—-- r- r- r- r- r- r- r-

C CM Ni cM CM C r r r r r r r τ '- <-r τ ^ τ τ ^ *τ -τ τ ^,w ιo ιn ιn ιo ιθ ιo vo ιo vo vo D vo vD ^

CM CM CSI CM C CM C CM CM CM CM CM CNI CM CM CM CM CM CM C CM CM CM CM CM CM C CM CSI CM CSI C CM CM C CM CM

U U ϋ 3 U D D D D D D D D ø_ 0- P- _ C_ C≤ P, C_ Cή 0ϊ & C* C* C6 C£ & Cύ U) ω U U i ύ ^[d U X X X X X X X X X X X X X X X X U> U) U) Ul U) W W r r r^ tt < t ft < tt l rH^' r r rH rH r r c^H fr ^ £« fr < U U U > U rl rl rl rH^, H rl r^

•H CM rH CM rH rH CM CM

^Q b N a H rt CQ Q Q < n U Q U Q [ι1 Nl X ft CQ U υ r- υ _: r- θ r_ u υ u _⁾ υ υ θ !-; _) υ u o _> υ o υ o O O JZ U J W U O rtcQoαωt- tt a u> α Q zo-υυυυzυozoυuozuo Z U UO Z U U in vo t— oo cn o H C tO T in vo r- oo cn o H csi rO '- in vo r- co c θ H C>ι ro τ ιn D r- oo m θ H CNi M r ιn vo r- oo σι θ H CM r *τ ιn co r- oo σι θ rH in in in in in vD vo vo vD vo vD vo vo vD vo r- r- r- r- r- r- r- r- r- r- e» ∞ oo oo oo ex> <x> ∞ ∞ cD cn cn cn eτ> σ-ι e-'ι cn cn cn cΛ o o o o o o o o o o .-H ι-H

Σ Σ Σ S 22 S © oΣΣ EHoEHoΣ EHoEHoEH o o o o o o fζ tt tt fζ tt <aj ι< sC r-C fH

rt rf - ro » in cM r- oo co io cn r- oo 'O' H ^ H ^ Λ ιn r• rl O H (^ι ^β - ιn ^l' (»l 'f (n ιo ^ ι n (J1 _ _ ιxι o Λ ^ n ιn <^ι a oo Λ to O O T i-H VD CN1 rH ω cJ ^ o ^o o ^£> (n r- ^ vo r H oo co iΛ C ^ vo ιo vθ rH cn r H C H ∞ o _D _> ^ vθ ιH rH vo cΛ cn r ro o o si rH '<. o CM CM T r- vo oo IΛ T oo o n oo cn oo oo r- t- co oo oo oo r- '3' τ τ ro ro cM ro r- oo r- CO r- 00 cn o^*i ι-H crt r- vo co cM σι -τ ro rθ 'τ r- vD Ln ιo ιr> cn o o θ r-H rθ 'T 'τ τ

§- _- M H H ri H ri H rH rH rH rH rH iH i-H rH rH rH i-H rH rH rH rH i-l rH H rH i-H rH CM H H rH H rH rH c-M oq cM CM CM CM CM CM CM ro ro ro co ro ro ro co

H oooooooooooooooooooooooo ooooooooooooooooooooooooooooooooo υ oooooooooooooooooooooooo ooooooooooooooooooooooooooooooooo α.

00 CM VO T rH 00 r- r- vo ^ ci o r- '- <» '!r r- H H i mr) CcMM ^ r σi cΛ r o H θ m * l H l N II 'J' CO ∞ VD T in σi CCM croO co a- vo in H oo in co r vD r in oo CM vo cn ro CM cn r- T uo ro cM O r- oo r- O T

'-r ro csi o r- co vvoo rrHH vo m o H θ θ H σι cM oo o τ r- r- t- •>- CM •>, o r- o σ> oo c- ro r- o ro rH -_ lO •_^l T CO i-H rH o o cn cn m in vo r- r- oo σι oo o oo O D in [^■» r- r- in r- r— CO VO VO IO '-' T CM CM CM O in T VD VD r- r- r- CΛ in CD T T CM CM rH CM H rH rH O O f-H rH rH rH rH H rH rH CM rH CM rH rH H rH H riHHHH HHrid riH H 1-H rH rH rH ιH rH rH ι-l rH rH H ι-I H H H H rH i-H rH rH rH rH rH rH t-H rH i-H i-H rH rH i-H rH rH r-I H rH rH rH rH in vo r- o CM en τ ιn oo rH co cD oo o cn τ _> o ro r- r- r- vo in o rH CM r- rH oo o o m m oo o oo in rH ro σ σι «_> vo ιn m tn ^,-^ι «- co cM θ '- ^,<- vo τ ι— O rH CM m CM r- in in ro cn cM O Vo o cM r- co r- t- vo vo oo τ r- ιn ιn co rH CN •=_ vo ro oo r- o cn r- vD _<--ι ιH CM VD τ cM m r rH cr> o co r- ro vo τι^ι ro oo cM

T in 00 rH VD CM T r- cn m ro cM H Co o r- CN σi cn vo rH O in cΛ c. cTi o r- oo rH VO rO rH CO CM ^ CM CM in o m r- oo ro in O '-' VO in r in vD VD CTi H rH H ιη H d H l ri N H N !I H O N H lη lO (0 '» ( ιn ιn H H O\ IΛ ^ ^ l!! U) O O O H ^l m ■I 1J ιn ω ιn 00100 IJ m OI ^ H N ri ^l N (l (! ^f ^f n ro co ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro co ci cM CM CM CM CM c»ι r ro ro ro c^

CO cM cn cM ro oo T rH in co r- vo vo m ^ cn T O CM r- o cM T CΛ en oo r— T CO CM CM ro vO rH o r— vo c m vO ji in o co ro ro r- ro cM in cM oo r- cn vo m r- ro ro in rH H rH cn σi r- in cNi rH oo rH cg ro ro o ro cn cM cn H CM CM T r— cn ro in cM r- m oo cM ro cn cM T ^' r- cM cn o vo T O CM m OO H CO C CM rH rH T rH VO in c_ τ θ τ cn cM CM co co H CM m τ _> rH cM r— vo r- vo cM iji oo o oo vo in r— T VO T Oo r— <n vo o τ r- ιθ H ro ro co O in H T O rH OO CD r- CO CΛ r— in VO m ιn τ ro oo m ro m ro ιn ro co cM rH rH CM CM CM Co ro «3^, o o oo ∞ r- r- r- r- r- _> m m τ m m m m vD τ τ ro cM H θ CM CM rH θ o cn cn o rH rH CM r- p- r- r- r- r- r- r- r- r- t- r- r- r- r- r- r- r- r- r- r- r- r— VO VO O VD VO VD VD CO VO VO C-l VO VD VD VD VD VD VD VO VO VO VO VO VO CO CO VO in in VO VO VO VO

^o o o o o o o o o oo H ri H H ri ri H H H H HN N NN i NN (iιri (^|i (^,i(^|i(^,i ⁽infli^,ιιn 9 ^ <ιi 'i' 'i^ι -» ιj ^ ι ιn ι ιn ifi ιnι c\i ro ro ro c ro ro ro n n ro (^ ro ro co ro ro c c co r c ro cn m ro ro ro ro r ro ro ro ro ro

ω ω ω w ω ω ω ω ω ω ω ω ω D D D D D D D D θ u o o o o o o ø o c_. ω ω ω ω [a ω w ω ω ω w

O Qj -j Cli CU Qj Qj Ci Qj a, κ κ κ κ κ :-. « « κ _: :_. _ B ω ω ω ω ω ω ω ω g ct; tf g g g H rH rH rH rH M αi øj &i Oi ^Qj αj C- ii C &i D-i αi αj i-i J μj Hj J H H H M hH rH X rH CM rH CM H CM CM CM rH rH CM rH rH

(C B U Q Q U U N r^ CQ - ^{Q Q} ω ω -, fiC CQ O D Q . <-.m _ U Q W N K S < Q - l_⁾ Q < ID O Z O U CJ U U U CJ- U O Z U U O U O U U U CJ O Z U CJ CJ U CJ U O Z U U J U Z U Z Z υozououυuozuuUυυQ Qzru1

N ⁽ ^ ιft ^ ^ α⁾ Λ O H c^ι n "I ιn » co m o H (^ι (n ^ ιn ^ ^ tD Ol O H N n ^ ιn ω ^ ιIl βι o H N π 9 ιn o ^ m βl O H N n ^ ιn w ^ _ H H H H H H H H CM C C C C C CM C C CN r r r ro ro r r ro ro ro -T ^ ^ ^ ^ -T 'T ^ ^ T i in in in in in i^

H H H H H H H H H H iH rH H H H H H H H H H H H H H H H H rH H H H H H H iH H H H H H H H H rH H H H H i-H H i-H H H rH H H

00 r- 1 VO rH

∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ rH Σ Σ o o o o o o o o o o o o o o ooo oo o oo o o o o o o o o oo o o o o o o o o oo o o o o o oo ooo o o o o o

-H EH eπ EH H EH EH EH EH EH EH H H EH EH tH EH EH H EH H EH EH EH H EH EH EH H EH EH EH H H EH EH EH EH EH EH EH EH H EH EH EH EH EH EH EH EH EH EH EH EH

O fζ ft r ft t fζ f£ tt tt fK tt ft ft f$ tt fC ft fC ft ft f£ tt fZ f$ fSl ft ft fZ ft f£ ft

Tabled

ATOM 169 NE2 HIS 35 62.825 32.895 110.998 1.00 35.40

ATOM 170 C HIS 35 58.353 32.356 114.874 1.00 30.61

ATOM 171 O HIS 35 57.996 31.209 115.132 1.00 30.59

ATOM 172 N PRO 36 57.560 33.411 115.084 1.00 30.75

ATOM 173 CD PRO 36 57.903 34.836 114.961 1.00 30.69

ATOM 174 CA PRO 36 56.216 33.247 115.628 1.00 30.14

ATOM 175 CB PRO 36 55.726 34.683 115.757 1.00 29.29

ATOM 176 CG PRO 36 56.990 35.460 115.966 1.00 29.66

ATOM 177 C PRO 36 55.346 32.422 114.680 1.00 30.78

ATOM 178 O PRO 36 54.359 31.823 115.096 1.00 29.83

ATOM 179 N ASP 37 55.716 32.391 113.404 1.00 31.83

ATOM 180 CA ASP 37 54.933 31.637 112.436 1.00 32.95

ATOM 181 CB ASP 37 54.958 32.305 111.057 1.00 32.63

ATOM 182 CG ASP 37 56.341 32.377 110.461 1.00 34.16

ATOM 183 ODl ASP 37 57.108 31.398 110.570 1.00 34.89

ATOM 184 OD2 ASP 37 56.654 33.420 109.856 1.00 35.19

ATOM 185 C ASP 37 55.351 30.181 112.305 1.00 33.57

ATOM 186 O ASP 37 54.767 29.435 111.523 1.00 33.17

ATOM 187 N GLY 38 56.362 29.775 113.065 1.00 33.49

ATOM 188 CA GLY 38 56.798 28.394 113.000 1.00 32.49

ATOM 189 C GLY 38 58.094 28.128 112.262 1.00 31.52

ATOM 190 O GLY 38 58.666 27.056 112.399 1.00 30.69

ATOM 191 N ARG 39 58.566 29.080 111.472 1.00 31.26

ATOM 192 CA ARG 39 59.810 28.869 110.752 1.00 31.69

ATOM 193 CB ARG 39 60.053 30.008 109.758 1.00 31.81

ATOM 194 CG ARG 39 59.171 29.980 108.515 1.00 32.81

ATOM 195 CD ARG 39 59.377 31.207 107.634 1.00 31.85

ATOM 196 NE ARG 39 58.932 32.417 108.317 1.00 34.13

ATOM 197 CZ ARG 39 59.088 33.652 107.847 1.00 35.53

ATOM 198 NHl ARG 39 58.649 34.687 108.553 1.00 35.87

ATOM 199 NH2 ARG 39 59.681 33.860 106.678 1.00 35.37

ATOM 200 C ARG 39 60.973 28.797 111.732 1.00 32.08

ATOM 201 O ARG 39 60.947 29.431 112.784 1.00 32.13

ATOM 202 N VAL 40 61.991 28.008 111.395 1.00 32.00

ATOM 203 CA VAL 40 63.174 27.902 112.244 1.00 30.66

ATOM 204 CB VAL 40 63.271 26.564 112.974 1.00 29.32

ATOM 205 CGI VAL 40 64.335 26.668 114.031 1.00 30.19

ATOM 206 CG2 VAL 40 61.961 26.210 113.611 1.00 28.68

ATOM 207 C VAL 40 64.443 28.083 111.422 1.00 29.72

ATOM 208 O VAL 40 64.609 27.476 110.374 1.00 29.97

ATOM 209 N ASP 41 65.335 28.930 111.912 1.00 28.45

ATOM 210 CA ASP 41 66.579 29.216 111.226 1.00 27.57

ATOM 211 CB ASP 41 66.326 30.164 110.058 1.00 26.38

ATOM 212 CG ASP 41 65.642 31.437 110.487 1.00 25.63

ATOM 213 ODl ASP 41 65.557 32.379 109.683 1.00 26.72

ATOM 214 OD2 ASP 41 65.181 31.496 111.633 1.00 26.67

ATOM 215 C ASP 41 67.507 29.880 112.218 1.00 27.61

ATOM 216 O ASP 41 67.252 29.853 113.410 1.00 29.10

ATOM 217 N GLY 42 68.576 30.487 111.726 1.00 27.57

ATOM 218 CA GLY 42 69.501 31.154 112.616 1.00 27.36

ATOM 219 C GLY 42 69.678 32.631 112.314 1.00 27.75

ATOM 220 O GLY 42 69.395 33.102 111.210 1.00 27.79

ATOM 221 N VAL 43 70.142 33.363 113.319 1.00 27.36

ATOM 222 CA VAL 43 70.406 34.787 113.199 1.00 28.43

ATOM 223 CB VAL 43 69.276 35.663 113.756 1.00 27.62

ATOM 224 CGI VAL 43 68.588 36.385 112.645 1.00 27.23 rt rt r- ro ^| r σ> τ <x> rH co o vD oo r <Λ rM '3^l <T) in r- ιn ι-ι cD σ-ι co m o ιn cn <n vo τ σι cn r cn T VD Ti c in o m r co r H rH ro oo rH r- o o vo i j rH r- τ r CM VD r- oo cM vo ι-H vo τ cD co τ o r- o rH in ro r- m m cTi T O ro m CM r- r- CM ro r- rH rH vo vD r- r- in r- cri cM CM 'T r- O '- CO OO CΛ o © cn cn cn cM ^r m oo o ro ιn vD r- "-- '- τ τ VD oo o o c ^ ι r csι o cn cΛ θ o cvι c Cv) CM H '-r r cM τ ^)' τ vD r-- r-- ι H θ rH o σi H r-ι o cn oo o. cM CM ro ro ro ro τ τ τ τ τ ro ro ro ro ro ro τ τ

H oooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H oo r- '-' O r- r- o ro r- r- ro o co vo vo m i-H O oo cM in oo co m co vo c CN cTi r- oo cri co oo ro cM cn ro in vo cn co rH csi σi co o m oo co en co m co in T Ci C r— «aι 00 in ro T c_o? τT cCHo rι^τo) rcoi o_> rcoϊ ccoi c_Λτ> ιuni 'T3' rr—- o cn vD θ O rr-- v VOo H VO VO CM O H VD Oo σi σi r-I VD rH o in o cM T c ,o , r ,— T - ccnn m in cnn cCΛΛ r r—— HH in O H T CM CO in in rH O CM r- CM CM Cn oO rH CO Cn cri rH rH ro rH in in n t- CM rH O O T OO T O rH T rO VO CΛ CJl OO CM I— r- τ ro oo co ro T CM m in cM

T ^•>. in ro »- ro CM o cn cn m vo T in m co ro cM in r- r- ∞ cΛ O H 'T in O H σ^ o^ σi oo cn oo r- o in T VD oo σv oo r- m co r- cn o co co r— rH rH rH H rH rH rH O O iH rH H rH rH rH rH rH rH rH rH rH rH CM CM CM CM CSJ CM CM rH H i-l rH rH r-l rH rH rH rH rH H rH H H rH rH H rH rH CM rH H H rH rH rH rH rH rH rH t-l rH i-H rH rH H H rH H H rH H rH rH i-H rH rH rH rH i-H i-H rH H H H rH rH H rH rH rH H rH rH r-l rH rH r-l rH rH

•<r o ιn ro ιn ro oo o r- m ^i' rH o σi cD τ vo cD oo O rH Cn C CM in H O OroO O r .H. H H T O in cM co cM vo m ro cyi cD rO rH r- cn co in σi oo rH rH CM Co

CM cn r- cM r- T in σi cD co co σi CM VO rH ro c rH o oo co o r- r- rH O T o rn cη cn cM cn ιn H σι cn o ιn oo r- ro cn r rH τ o σι ro r- ro σ> oo <τi -) cD O _' _3 iH in r r- iD vo r- in r T H CM rH r- in r- oo oo cM o r- o vo in rH c>j ^j' < i in cM r- cn r- rM oo cM cn m rH Vo σι ro ro cM θ θ θ »_> cM r- ro o

T in T in vo vo m m T T m ro r- r- oo cn o O H rH rH oo c» cn cD cn cx) cn oo cn σι c» θ H C CN θ H en cτι r- r- c» co c» oo cn o cn o o r- r- co ιn ιn co ro ro ro ro r ro ro ro ro ro ro ro ro ro rO T *"— iljⁱ T "i, m r o m r r r r c o ^ ^ T '-i 'T '- e r ro c r r r M 'T M T ^ ro ro ro ro ro oo o τ r- m oo cn r- m m m ro co cM rH ro cM H cn ro r- ro r- vo r- ro T Csi oo 'T t-i θ ι-H oo m cM vo oo oo o vo o oo cM θ o cD r rH oo τ o ιn ιn ιn σι r- H CNi ro oo τ co vo vo ιn r- oo ro ro cM eτι o vo τ ι-ι τ o o ιn r- -^' rH in τ ro σi ι-H σs cM O r- r—

^■H rH CM rO ^l' in VO r- r- OO OO rO ^P C-J CM rH i-H CM r r rH O CM ro CM T ^■^ c o r- r- r- r- r- r- r- r- r- r-. r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- i- r- r— r— f—

m cη ro *- τ τ τ ^,«j^ι τ τ τ '*3' '- τ ιn m m in m in in in m vo vo vD VD CO cD vo co vD t— r— r— r- r- r- oo oo oo oo oo oo co co cn eΛ cn σ> exι σι σ> o o o

^*ϊ* ^J^ ^3* ^Q* ^J* ***_*J^ ^3* ^1* ^-3^ ^J' ^1* ^3* ^3* ^1* ^•'^ ^3^ ^ϊp ^ ^3f* ^jI*ι ^^ϊj** ^ ^3j** ^3¹ tj* *ζp ^J* ϊj* *ζT "•J' *--* ^* ^P ^* ^* ^* ^J* **-' '■3' ^* ^3* ^* ^* ^3* ^* "^ ^* ^* ^3* "51* ^3* ^J* *«P ^3* ^* LO LO LO

C3 C3 _> _> _> _) _> _) _> _> ->

«! U U U O O ϋ U ϋ D D D D D D D D D M t0 B^{) (} n ffl W 01 01 I, Di ⁽- l. l^j; i- ⁽lι l- l, (lι l- ⁽lι l- ⁽, O O O O O O O Iβ M C

(-. <-, C_ M " & " C "ύ O "i t "ύ t "ϊi l -ύ' C "ύ H rl rl rΑ rΑ rΑ r rl rΑ X X X Ui a U Ui U W W W W tn

> > > ft ft, ft. ^ l^ l^ ^ ^ rtJ rtl P^ O U O ei U U U U H^ HH HH H^ HH HH HH HH HH C W W W W l^ rH CM rH CM rH CM j rtffl - Qi- Nas co e> α ω ω ft, CQ ID Q ω I ca o < I0 U Q Q α co o ft CQ o υo z u u joz o z z o o z υ υυu o o u o z u ouυ υ z o o z o o o υ o z ou υo o uo z υ υ υ u υ o 2 U U in vo r- oo cn o rH CM ro ^j' in vo r- e» cn o H C ro τ ιn vo r- cχj σ θ H CM ro ^ ιn vo r- cD c o H C ro τ ι vo r- oo cn o H cN ro ιn vθ [— oo cn o c C CM CM CM ro r r o ro co r i^ ro rO T ^ ^ '-r T 'W T 'T ^ T i in in in in in in in in in vo cD co vo vD vo vD ^

C CM C CSl CSJ C CM CM CM CNi CM CM CM CM CM CM C CM CM CM CM CM CM CM C CM CNl C CM CNl CSl CN C

00 ^■π vo

Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ © O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O EH EH EH EH EH EH EH EH EH EH EH H EH EH EH EH EH EH H EH EH H EH EH H EH H EH EH EH H EH EH EH H EH EH EH EH EH EH EH EH H EH EH EH EH H EH EH EH EH EH EH EH o ft et ft f rt ft ft tt fZ ft, tζ tt fZ < ft rt tt < ft ft ft < tt tt < tt tt < Z f^

r '- r- m o T ^r in T rH crv o r vD H in n vo oo T CM c- cM Oo m oo in -. r- t- vo oo oo vo 00 r- T3ⁱ C Cri [— OO in OO r- O m rO C l rH CM in rH CM '- VD VD O CM ^ n n « ι^ ιr» ιn ιn ^ w o (θ ι w ^ ^ cvι^'N N ro ^ ^•j tm N O H O in CM CM CM CN CM CM CM CM CM eM CM rO C^ CM CM CM CM CM CM CM CM CM ooooooooooooooooooooo O O O O O O O O ooooooooooooooooooooo O O O O O O O O

W ri O O O in O N iB iΛ in eo i Φ ^ tf o ^ in β in i ii N in ^ H O fi tn ri N in ri i W o o v iO i f iD fli fli ri N T vo o ro in CM ro ι o o3 W * ^ ιrι cD _ _ ^ n o3 ^ |1 |r| 1_J m 1_f o w n ιn l 0l ^B oo N lO W H ^ tπ c^l ri ri t voo ^r— πoo HrH rocθ rrH^ oθ ιιnn oo ^r'oι ιιnn τ r- r- ro ιn ιn ro h i ^ r~ 03 ^ in co fl (i\ o r- i^,i t~ H iri ( iB H in o> 'o * i!i o n o O <Tr rHi imfl iroo (o»o HiH iin oi oo oo i cτnι oo imn imn ^'3^, «'3' ir»o) rr- Nc^, ii— ooo m vo vD r- rH m σi vo in t— vo in oo oo cn cn cj-i t— o σ> H H CM ro τ τ ιn ιn vD ro ro ro τ r CM H H in vD in r- ι^ ∞ o o θ r- vo r- r- t- vD ιn tn cn cn oo cn cn o cM CM CM

CM C CM CM CM CM C CM C CM CM CM C CM CM CM CM CM CM CM CM CM CM n rO rO CM CM CM CN CM CM CM CM CM CM CM CM C^

00 VD 1— rH r- r- o ro ro ro vo vo o r- cn m cM cn m r- m m ro o cM O rH r- o co cM rO rH CM in cTi ro m vD C e^*τnι VVDD iιnn Tτ CcM rr—- M Vo cn r^-- oooo iιnn CcMM v_o> rroo H rro HH rHH oO mιn rmo Tτ c iιnn r^oo oo T'τ Oooo mι ccnri cσι c'o_ι •- r- ro cn rH cn CN o , rH CM ι-ι cn cn oo o σι cM σι r- o τ r- o <Λ ro ro r- ro cM r- r- CM CM vo rH co uι σι ιn vo r- θ ιH cn cM CM rH oo oo cM θ r- ro co vo rH 1, o vo σι oo vo cn rH r- τ ι-H H '-' θ m o τ ιn r- C'M ro cM vD vo co r- r- '- r ^j' n '-' T m vo oo r- r c T in c— oo r— cM CN H n co < co cn eΛ eΛ c» oo c» cx> oo cn r- vo ιn vo ^ τ ι ^,τ ιn "9' ^,- ro c C rH r rθ H ro ro ro rO ro ro co ro co ro ro ro ro ro ro co ro ro ro ro m ro ro ro ro csi CM CM CM CM CM CM CM CM r-

H H o _ o ι'l N H o o o rl _> _VD VD tfl VO

in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in i^

ω Cd ω cd ω ω W W W CO

_H3 _H3 _H} .J _H3 _H3 _H3 :>H H < H

X X X X X H M rH rH M M M rJ HP J Hj

N ri H M

O ^Q Q ω C-l ■a; CQ CD _⁾ Q m cQ CJ Q ω si muo Q CQ o α ω M «; m u Q Q . ., („O U Q W _ W„ CJ O Z CJ z υ 0 z υ o o o υ u o Z U CJ o o u z u o z o υ υ υ uυ o z cj υ υ o o z υ o z υ u υ υ uo o z c u u u oz iH CM O T in ^β vo ^ ∞ m o H t^ι n « ιn ^ ^ ffl m o H ι ιη ^ ln ιo ^ co <Jι o H ι n ^ ln ιo ^ oo (Λ O H N lO '» ιn ^ ^ ιxl Ol O H N ( ^ ιn - 00 0001 l 0ϊ0l l 0I0⁾ α 00i lD ω _ _ II101 ⁽Il ⁽J> m θl Φ m <I\ m θ O O O O O O O O O ri H H H ri ri H H H ri N (\| ( N <\| (V! N (\l « (\| l'i n (^ll ('I M (') l'l

CM C CM M c M c CM CM c cM CM C CM M CM CN ro r r r ro r r c cη M rη r^ oo

ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ

0 EH0EH E0H H0E0H0H E0H0EH0H H00H0EH0EH0EH0EH0H0EH0EH0H E0H0EH0H 0

. E0 .H E00 .H. .H 0 . E0 .H. .EH. E0 0 .H0 . E.H. E.H E0 . .H0EH0EH 0000000000 h t* H H H H t< _i t _ 0 H H . 0 t. 0 H t. 0 i t _ 0 < H. 0 h . 0 0 H. t.0 H .H h _ 0 H . 0 £ . 0 H H . o eC tt ft ft fi fC fi tt ei tζ fK fζ ti fζ fZ eC ft fZ fC t tt f fCζ fr$, tr£ζ, tett, frϊζ_t f(£^, r£, r£, ft, e£, ff, r£,

Table ό

ATOM 337 C GLN 56 62 . 921 20. 963 129. 569 1 . 00 25 . 91

ATOM 338 O GLN 56 62. ,989 20. ,426 128. ,468 1. 00 28. 11

ATOM 339 N ALA 57 63. ,157 20. ,318 130. ,701 1. ,00 26. 95

ATOM 340 CA ALA 57 63. .483 18. ,902 130. ,677 1. ,00 28. 44

ATOM 341 CB ALA 57 64, .433 18. .549 131. .819 1. .00 29. ,12

ATOM 342 C ALA 57 62. .185 18. ,150 130. ,830 1, .00 29. .10

ATOM 343 O ALA 57 61. .320 18, ,559 131. ,605 1. .00 28. ,67

ATOM 344 N GLU 58 62. .029 17, ,070 130. ,072 1. ,00 29. ,83

ATOM 345 CA GLU 58 60, .820 16. .274 130. .181 1, .00 30. .65

ATOM 346 CB GLU 58 60, .346 15, .824 128, .811 1. .00 31. ,00

ATOM 347 CG GLU 58 58, .857 15. ,539 128, .757 1, .00 32. ,60

ATOM 348 CD GLU 58 58, .027 16, ,723 129, .207 1, ,00 33. ,58

ATOM 349 OEl GLU 58 58. .392 17, .869 128. .858 1, .00 33. .56

ATOM 350 OE2 GLU 58 57. .008 16, .506 129, .901 1, ,00 35. .63

ATOM 351 C GLU 58 61, .188 15, .078 131. .036 1, .00 30, .91

ATOM 352 O GLU 58 60, .333 14, ,344 131, .515 1, .00 30, .95

ATOM 353 N GLU 59 62, .489 14, .916 131. .232 1. .00 31, .82

ATOM 354 CA GLU 59 63, .040 13, .841 132, .031 1, .00 31, .78

ATOM 355 CB GLU 59 62, .496 12, .499 131, .578 1, .00 33. .64

ATOM 356 CG GLU 59 63, .031 12, .038 130, .260 1, .00 36, .93

ATOM 357 CD GLU 59 62. .664 10, .602 129, .993 1, .00 39, .85

ATOM 358 OEl GLU 59 61, .461 10, .331 129, .790 1. .00 42, .02

ATOM 359 OE2 GLU 59 63, .571 9. .741 129. .999 1. .00 41, .11

ATOM 360 C GLU 59 64, .529 13. .873 131. .821 1. .00 30, .93

ATOM 361 O GLU 59 65. .005 14, .502 130. .880 1. .00 31, .63

ATOM 362 N ARG 60 65, .259 13, .186 132. .688 1. .00 29, .47

ATOM 363 CA ARG 60 66. .710 13. .123 132, .609 1. .00 28. .68

ATOM 364 CB ARG 60 67. .196 11, .887 133. .344 1. .00 30, .06

ATOM 365 CG ARG 60 68. ,340 12. .140 134. .272 1. .00 34, .02

ATOM 366 CD ARG 60 68. .351 11, .091 135, .363 1, .00 38, .00

ATOM 367 NE ARG 60 68, .988 9, .853 134, .937 1, .00 41, .17

ATOM 368 CZ ARG 60 70, .275 9, .754 134, .610 1, .00 43, .17

ATOM 369 NHl ARG 60 71. .064 10, .819 134, .653 1, .00 43, .52

ATOM 370 NH2 ARG 60 70, .787 8. .579 134, .266 1. .00 45, .60

ATOM 371 C ARG 60 67. .236 13. .083 131, .181 1. .00 27, .56

ATOM 372 O ARG 60 66. .915 12, .163 130. .420 1. .00 26. .74

ATOM 373 N GLY 61 68, ,036 14, .093 130, .834 1. .00 25. .42

ATOM 374 CA GLY 61 68, .650 14, .179 129. .521 1, .00 23, .18

ATOM 375 C GLY 61 67. .769 14, .499 128, .336 1, .00 22, .45

ATOM 376 O GLY 61 68. ,255 14. ,571 127. ,206 1, .00 22. .39

ATOM 377 N VAL 62 66. ,480 14, .696 128. ,576 1. .00 21. ,70

ATOM 378 CA VAL 62 65. .559 14, .991 127, .488 1, .00 21. .36

ATOM 379 CB VAL 62 64, .467 13, .948 127. .390 1, .00 21, .25

ATOM 380 CGI VAL 62 63, ,545 14, .300 126. .255 1. .00 20. ,20

ATOM 381 CG2 VAL 62 65. ,086 12. .578 127. ,184 1. ,00 22. ,19

ATOM 382 C VAL 62 64, ,891 16, .330 127, ,660 1, ,00 21. ,42

ATOM 383 O VAL 62 64. ,329 16, .625 128, .718 1, ,00 21. .01

ATOM 384 N VAL 63 64. ,922 17. .131 126. ,607 1, ,00 21. ,21

ATOM 385 CA VAL 63 64. ,331 18, .451 126. ,684 1, ,00 22. ,02

ATOM 386 CB VAL 63 65. ,419 19. ,536 126. .680 1, .00 21. .49

ATOM 387 CGI VAL 63 66. ,481 19, .213 127. .704 1. ,00 21. ,73

ATOM 388 CG2 VAL 63 66. ,026 19. .650 125, .290 1, .00 20. .18

ATOM 389 C VAL 63 63. ,387 18. ,808 125. ,553 1. ,00 23. .18

ATOM 390 O VAL 63 63. ,413 18. .210 124. .477 1, ,00 23. .67

ATOM 391 N SER 64 62. .550 19. ,798 125. .827 1. ,00 23. .91

ATOM 392 CA SER 64 61. .649 20. ,350 124. .839 1. ,00 25. .35 Table 6

ATOM 393 CB SER 64 60.254 20.585 125. ,427 1.00 25.45

ATOM 394 OG SER 64 60.157 21.858 126. .047 1.00 25.74

ATOM 395 C SER 64 62.380 21.686 124, .670 1.00 26.31

ATOM 396 0 SER 64 63.103 22.105 125, .584 1.00 26.97

ATOM 397 N ILE 65 62.243 22.333 123. .516 1.00 25.31

ATOM 398 CA ILE 65 62.889 23.624 123, .302 1.00 23.48

ATOM 399 CB ILE 65 63.965 23.536 122, .239 1.00 21.26

ATOM 400 CG2 ILE 65 64.493 24.913 121, .921 1.00 20.99

ATOM 401 CGI ILE 65 65.087 22.637 122. .730 1.00 19.95

ATOM 402 CDl ILE 65 66.175 22.427 121. .710 1.00 18.86

ATOM 403 C ILE 65 61.793 24.551 122, .833 1.00 24.23

ATOM 404 O ILE 65 61.307 24.432 121, .717 1.00 26.34

ATOM 405 N LYS 66 61.398 25.476 123. .688 1.00 23.45

ATOM 406 CA LYS 66 60.315 26.376 123. .347 1.00 24.16

ATOM 407 CB LYS 66 59.308 26.366 124, .490 1.00 25.18

ATOM 408 CG LYS 66 58.083 27.234 124. .309 1.00 26.80

ATOM 409 CD LYS 66 57.169 27.059 125. .526 1.00 28.71

ATOM 410 CE LYS 66 56.044 28.085 125, ,597 1.00 29.36

ATOM 411 NZ LYS 66 55.434 28.077 126. .956 1.00 30.03

ATOM 412 C LYS 66 60.743 27.801 123. ,049 1.00 24.99

ATOM 413 O LYS 66 61.398 28.451 123. ,861 1.00 26.36

ATOM 414 N GLY 67 60.383 28.288 121, .871 1.00 24.39

ATOM 415 CA GLY 67 60.721 29.649 121, .535 1.00 23.66

ATOM 416 C GLY 67 59.802 30.486 122. ,394 1.00 23.71

ATOM 417 O GLY 67 58.590 30.370 122, ,280 1.00 23.31

ATOM 418 N VAL 68 60.363 31.325 123, .253 1.00 24.43

ATOM 419 CA VAL 68 59.538 32.137 124. .143 1.00 25.58

ATOM 420 CB VAL 68 60.412 32.961 125. .102 1.00 24.89

ATOM 421 CGI VAL 68 59.547 33.906 125. .913 1.00 24.50

ATOM 422 CG2 VAL 68 61.163 32.038 126. ,026 1.00 23.51

ATOM 423 C VAL 68 58.569 33.075 123, .425 1.00 27.13

ATOM 424 O VAL 68 57.374 33.093 123. ,725 1.00 27.43

ATOM 425 N SER 69 59.097 33.845 122. .480 1.00 27.71

ATOM 426 CA SER 69 58.318 34.802 121. .706 1.00 27.80

ATOM 427 CB SER 69 59.279 35.657 120, .871 1.00 26.55

ATOM 428 OG SER 69 58.652 36.153 119. .712 1.00 23.62

ATOM 429 C SER 69 57.293 34.135 120. .791 1.00 28.43

ATOM 430 O SER 69 56.116 34.493 120, .784 1.00 27.80

ATOM 431 N ALA 70 57.754 33.161 120, ,019 1.00 29.44

ATOM 432 CA ALA 70 56.890 32.455 119, ,085 1.00 30.39

ATOM 433 CB ALA 70 57.739 31.672 118, .090 1.00 30.34

ATOM 434 C ALA 70 55.911 31.526 119, .793 1.00 30.53

ATOM 435 O ALA 70 54.949 31.043 119, .197 1.00 30.39

ATOM 436 N ASN 71 56.147 31.285 121. .071 1.00 30.77

ATOM 437 CA ASN 71 55.271 30.407 121, .817 1.00 32.78

ATOM 438 CB ASN 71 53.970 31.137 122, .123 1.00 32.63

ATOM 439 CG ASN 71 53.257 30.571 123. ,330 1.00 33.86

ATOM 440 ODl ASN 71 53.857 30.378 124, ,386 1.00 35.51

ATOM 441 ND2 ASN 71 51.968 30.315 123, .186 1.00 34.15

ATOM 442 C ASN 71 54.996 29.129 121, .008 1.00 33.89

ATOM 443 O ASN 71 53.848 28.735 120, .803 1.00 33.35

ATOM 444 N ARG 72 56.074 28.502 120, .543 1.00 34.56

ATOM 445 CA ARG 72 56.014 27.271 119, .764 1.00 34.30

ATOM 446 CB ARG 72 56.245 27.545 118, .280 1.00 33.36

ATOM 447 CG ARG 72 55.174 28.321 117, .553 1.00 33.71

ATOM 448 CD ARG 72 55.635 28.572 116, .110 1.00 34.74 Table 6

ATOM 449 NE ARG 72 54.624 29. ,232 115. ,290 1. 00 35. 27

ATOM 450 CZ ARG 72 53.545 28. ,632 114. ,798 1. .00 33. 89

ATOM 451 NHl ARG 72 53.327 27. ,349 115. ,028 1. ,00 33. 02

ATOM 452 NH2 ARG 72 52.670 29. ,324 114. ,089 1. .00 34. 07

ATOM 453 C ARG 72 57.138 26. ,369 120, ,242 1. ,00 34. .85

ATOM 454 O ARG 72 58.046 26, ,819 120. .934 1. ,00 35. ,82

ATOM 455 N TYR 73 57.092 25. ,102 119, ,846 1. ,00 34. ,88

ATOM 456 CA TYR 73 58.120 24. ,149 120. ,233 1. ,00 33. ,16

ATOM 457 CB TYR 73 57.488 22. .981 120. .971 1. ,00 29. .48

ATOM 458 CG TYR 73 56.795 23. ,390 122, ,244 1. ,00 27. ,00

ATOM 459 CDl TYR 73 55.509 23. ,920 122. ,224 1. ,00 25. .62

ATOM 460 CEl TYR 73 54.878 24. ,301 123. ,396 1. ,00 23. ,39

ATOM 461 CD2 TYR 73 57.432 23. .258 123. ,474 1. .00 25. ,71

ATOM 462 CE2 TYR 73 56.812 23. ,640 124, .645 1. ,00 23. ,18

ATOM 463 CZ TYR 73 55.537 24. ,158 124. ,601 1. ,00 22. ,75

ATOM 464 OH TYR 73 54.923 24. ,525 125. ,770 1. ,00 22. .37

ATOM 465 C TYR 73 58.909 23. ,638 119, .045 1. ,00 33. ,61

ATOM 466 O TYR 73 58.339 23, ,297 118. ,019 1. ,00 34. .53

ATOM 467 N LEU 74 60.225 23. ,595 119, ,184 1. ,00 33. .83

ATOM 468 CA LEU 74 61.077 23. .108 118, ,113 1. .00 35. .21

ATOM 469 CB LEU 74 62.538 23. ,322 118. ,471 1. ,00 32. ,63

ATOM 470 CG LEU 74 63.465 22. .385 117, .715 1, .00 30. ,54

ATOM 471 CDl LEU 74 63.375 22, .702 116, .241 1, .00 30. .96

ATOM 472 CD2 LEU 74 64.871 22, .523 118. .226 1. .00 29. ,71

ATOM 473 C LEU 74 60.835 21. .621 117. .924 1, .00 37. .36

ATOM 474 O LEU 74 61.081 20, .837 118. .839 1, .00 39, .11

ATOM 475 N ALA 75 60.358 21. .231 116. .747 1. .00 38. ,42

ATOM 476 CA ALA 75 60.097 19, ,825 116, .460 1. ,00 39. .22

ATOM 477 CB ALA 75 58.609 19. ,583 116. .394 1. .00 37, .95

ATOM 478 C ALA 75 60.751 19, ,431 115. .146 1. ,00 40. .58

ATOM 479 O ALA 75 60.800 20, .231 114, .208 1, .00 41, .93

ATOM 480 N MET 76 61.268 18, .207 115, .084 1, .00 41, ,48

ATOM 481 CA MET 76 61.908 17, .717 113. .868 1, .00 42, .71

ATOM 482 CB MET 76 63.269 17, .129 114. .179 1, .00 41, .17

ATOM 483 CG MET 76 64.039 16, .797 112, .949 1, .00 40, .91

ATOM 484 SD MET 76 65.732 16, .444 113, .338 1, .00 43, .31

ATOM 485 CE MET 76 65.586 14, .747 113. .794 1, .00 43. .79

ATOM 486 C MET 76 61.037 16, .649 113. .222 1. .00 44, .35

ATOM 487 0 MET 76 60.809 15, .591 113, .799 1, .00 44. .28

ATOM 488 N LYS 77 60.554 16, .941 112. .019 1, .00 45. .83

ATOM 489 CA LYS 77 59.697 16, .029 Ill, .280 1, .00 47, ,28

ATOM 490 CB LYS 77 59.056 16, .770 110. ,112 1, .00 47, .05

ATOM 491 CG LYS 77 58.522 18, .160 110, .444 1. .00 45, .60

ATOM 492 CD LYS 77 57.128 18, .135 111, .039 1. .00 44. .56

ATOM 493 CE LYS 77 57.155 17, .746 112. .499 1. .00 44. .94

ATOM 494 NZ LYS 77 55.799 17. .813 113, .127 1, .00 45, .37

ATOM 495 C LYS 77 60.496 14. .843 110, .749 1. .00 49. .12

ATOM 496 0 LYS 77 61.725 14. .839 110. .805 1. .00 48. .68

ATOM 497 N GLU 78 59.793 13. .846 110. .211 1. .00 51. .45

ATOM 498 CA GLU 78 60.444 12. .643 109, .690 1. .00 53. .04

ATOM 499 CB GLU 78 59.407 11, .583 109. .288 1, .00 54, .65

ATOM 500 CG GLU 78 58.566 11. .923 108, .071 1. .00 58. .25

ATOM 501 CD GLU 78 57.760 13, .198 108, .258 1, .00 61, .11

ATOM 502 OEl GLU 78 57.160 13, .370 109. .350 1, .00 62, .28

ATOM 503 OE2 GLU 78 57.719 14, .022 107, .313 1, .00 61, .51

ATOM 504 C GLU 78 61.425 12, .855 108, .539 1, .00 52. .66 H O vo vo OO OO

C vMg r r-H1 σ _iι r ι —H I r I—H I V —O ' C VMN σ _ιι V *_O• i UnJ r ιθ*l H 1 — I —)Ji* e i—ni τ "- l I—— C 1M1| T "M* r I —H I i uO ^ in C O 1 — I rO O VD OO CM iH CO OO Tr VD r- O r- O CΛ CM CM r- O Cn CM VO VO CM T T O CO rO ro r- r— vo m o co oo m m in o in r- cM O vo r- 0 - H OMO ffi » in o σi r- oo cn o rO rH o cn r- oo oo cM oo ro H CM t— r- cn ^j^ι τ τ ιn cM t- τ oo τ vo m τ σ> rH rH θ ro ro σ> cn o vo vD in r- ιn σi cn r- CM cn co cM in c oo c ro cM in ιn vD cn o cD θ^ r- r vD c oo co τ co θ 'j' 1— vo vo vo o vo rH oo r- vo ιn m ιn r- r- vo oo oo co cn oo co r- [— cD vo vo co t- cn o o H CM CM CM CM rH o cM CM rH i-i CO O CO τ τ ιnvo m m vo vor- r- r- oo r- oo co oo co

O O O O O O O O O O O O O O O O O O O O O O O rH rH rH rH rH H rH rH H rH rH H rH H rH H rH rH rH rH H rH rH H rH H m VO OΛ CO l— n _ ( H N f ^ O H ( H in ^ (D m H ^ H m eθ * (! O Φ W \|i N 01 r-l (D ^ h H N ^ H CΛ CO N V H N in θl in r- Cθ r'I O 'J

H ( ^ co o^ ιn ιfi N lB n Φ ^ o ^ N o o3 ^ ^ fl ^ ^ « n * cD H ^ n w Λ » lD n o n o H m ιn » ^ 0 (o <Λ ^ H ιr) Ol (ι r-^• o σl <^ o iH oo o oo rH o ro r- oo rH r- CM cn oo ro r— ^ ω r-• w <f » oo H O ^O l m ιIι ιn ιrι o o3 ^ N oo ()l <> [ m ^ o H ^•-• ιn w ^ (Λ lfl ι») Φ ^ <Jl (n -)

CM ro τ r co r- vo τ τ ιn ιn r- r- r- cn cn cn σι cx) r- cχj <n en H H CM tH CM θ CM ro r Cθ n H

H H H H ri H iH ri ri rl H d H H H ri H H H H H H H N CI N N N N N N N N M N N N N N N W N N N N N N N N M N N N tNI N oo m H r- vo r- ιn τ vo cτi cτι uι o cM CM CM Vo cΛ rH θ ιn ro ιn VO O PO CM '^l' T CO r- OO O rH rH cn cn τ H r- ro co H cn co ^,. τ <Λ oo o vo σι o oo oo ιn cn rH vovo Tino invo mooocMCM (-) H H in cn vD ∞ τ co c ιn ιn ιn rn r M c» o ιn co ^ _ι ∞ r- o co τ rH θ r- r- rH r- ro cM

(! H N H o o on v iΛfl β ιn mι N o θ(. ioΦN ιn(i) "» v fiv'i^, NM θ ciri vD vo vD VD vo vD CD co co vo vo vo vo vD vo vD vo cD in in in in vD

c» m cΛ c eΛ σ cn cn c o o o © H H H H H ιH H H H H H C CM CM CMCN CM M CM r ro co ro r ro ro r τ τ τ τ τ ι ιn ^

^ r--^r-•t-^^ ^ι--•^ ωωωω»»ωωωra∞ω∞ω _ω_ ro»ro_ _ ∞ωωωωωωω _ω»ω _∞„ _ro „ raω _ωω ωco

D OH OI C ^ BJ OU I^ QJ ^ ^ ^ ^ O U O O O O O U O O O O D D O D D D D D D D D D D D E- tt ft e ύ cύ cύ ύ m « co w co w w o tn cn w w co « w j ^ j j ι_ oζ ώ oS oS o, βi Λ Λ oi « M W H U W W U U w w _{H H}-1 _H-I ω w ω ϋ

0 <; < < I< << ⁽I; U U U I5 (I; S ^ «; < S << < J J ^:1 HI IH ₍H IH J J J _IJ J IH IH IH H1 rtK uln w n n in n ^ iH hH iH Hi

O z ⁱn co r- ω n o d c^\ι ιη ^ ⁱΛ « ω m o H N n ^ ^ ιo ^ o3 m o H ⁽vi ⁽η ^ιj ιn W ω Λ θ H N ⁽ ^ iΛ W (» m θ H N n 'tf in i- ω ⁽Λ o

O O O O O H rH H H H H H H H H C C C C CM eM C C M CM r r ro r rO rO r M M ^ -T in in in in in in in in in in in in in in in in in ui in in in in in tn in in in in in in in in in in in in in in in in in in in in oo

ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ∑∑∑∑∑∑∑∑∑∑Σ∑∑ΣΣ∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑ o o E^HoE^HoEHoEHoE^HoE^HoE^Ho-HoE^HoE^HoHoE^HoE^HoE^HoE^HoEHoHoHot^HoHoE^HoE^HoHoE^HoE^HoE^HoEHotHoEHo^HoE^HoEHoEHoE^HoE^HoHoE^HoE^HoE^HoEHoEHoE^Ho^HoEHoEHoE^HoEHoEHoEHoEHoEHoEHoEHoHoEHoEH O tt t ft < fZ ft ft tt fZ ft ft fC ft f£ f$ fZ tt t tt f < ft ft < t t t t f^ it

CM ro cM f- CM Vo m vo cM co r- oo oo cM r- CM m vo o ro '«r ro m ι o vo o o σι ιn oo M θ τ co c o c θ vo c in rH r- ^r .^r.^, _ r- r m o rHι ,inι «T. _n . O-. T- _« m H o T OO rH C— CM OO rH

T cn cn cn r- oo oo r- oo r- σi o in cO rH T T Oo rH vo VO CO H T T CM Cn o m CD rH CM oo <n cn o cτι o o σι o σi rH CM co ro τ rH rH θ o cn rH CM rH CM ro ro ιn ro m τ m rH H rH CM rH CM CM rH CM rH CM CM CM CM CM CM CM CM CM rH CM CM CM CM CM CM CM CN CM CM CM oo oo σi o o o m m o T T σ^ ro r- r- H r- m rH in rH CM r- ro oo vo ro oo oo vo o^ cn oo o m iH i-. o_ r.- VO rH CD ro o m h H Λ in CO lΛ Λ H W H O oo r- oo ιn co o σι τ σ> ιn H Vθ H r- © vo © vo r- co t- oo T Cn ro vD ro o cM CM O r- O rH ro oo oo r- ro vD o rO T VD rH Cn VD rO H VD OO r- rH O rO β N Ui N n in β o i'i o β t-' in ^ oo ^ H r* ** m CN 0ϊ l0 H (0 *3^, O C0 VD C0 C0 H 00 CM '_ rH T H O T O Cn O T oo o m H O T C O CΛ VD in cn o T in ro cM rH rH rH iH O c cn oo o oo oo r- vo vo vo t- in vo •r ro c H C O co r ^ in in '. ^ in T VO r- D oo cn cri r- oo vDvD tn in vo invo in vD

CM CO CM CM CM CM CM CM CM CM CM i-H H rH CM H H rH rH rH rH rH H rH

H en *τ cM C θ vo ιn cM τ

H C vo cM θ r- vo cM θ H 'j r>i M co«)θi r* (ιc! « ri θ H <)' m o <]¹ vo m oo oo r— ι» o ιτι ιno iθ Nm wι<) θ '» α) iJi(i! Nθ H ij>ιθ o o H H H rt o m ι r o^ n ^ ιΛ ^ n c^ι v f ι ln nιnw ιn ιo ^ ιn ιflw flo ^ co oo ^ oιn Λo ∞ ι)1ιι oo o H H O O (»co ^ ^ in in in in in in in T in in in in in in in in in in in in in in in in in in Ln in in in in in in in in in in in in in vo in in in in vo v^

Φ ιo ^ ^ ^~ ^ ^ ⁽D ω co α⁾ α⁾ oo oo o1 lΛ Ol Ol ⁽Il lJl ⁽ll o o o o o o o o H H H ri H H ^^ H H ι N ^ι N !^l ⁽ ι^,) ⁽ ιn M ι 1 ⁽O f1 m

CO CO OO OO CD CO CO CO CD CXl CO CO rø CO CO CD CΛ ∞ CO CO CO CO CO CO Cn cn cn CΛ W CTl CΛ Cn C^

OQ CO C CO D- Cri O- O- D- O- IH HI IH HI H oiiijti fii Biiii b baiPi h Bi cii CLiD DD DD D- can t røcQinωω i- ωω ωiii iiiN

>H H < >H ω H ω ω c-i t-i . . rt; . x x x „ a sxw oι iΛωnwnΩHiiHHi HiJJιJHiHi <x H >tχ tS!i! Ba! B s s a!_

> > > ^ h H H H ^ < < < < U U O O 5 (30 l50 ϋ U U U U U Ilι l- l- (lι ι Ciι |l. (- (- rH CM rH CM H CM rH CM H CM rH CM

U tM ft CQ CD ft CQ CD CD rt, CQ CD CD rtJ CQ CD Λi OQ O Q Q W td N o zo o z o υ ocj o UUUUU o z u o o o uo z α u cj o o o o z u u cj oo o u o z uo c o z U U U U ϋ U U U

H r^|l ^•sr in vo r- ∞ σi O rH CM co T in vo _ o O O O O O O H rH H H rH H H in CD VO VO VO VO VO VO VO VO CO CD VD VO VO

00 rH

ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ∑ΣΣΣΣΣΣ∑ΣΣΣΣΣΣΣΣΣ∑∑∑∑∑ΣΣ∑∑∑ΣΣ∑∑∑∑∑ oooooooooooooooooooooooooooooooooooooooooooooooooooooooo o ft ft ft ft ft t f f f ft ft ft ft f ft t f f f t f f t t ft t f t f^ it

rt rt r- ro vD CM CM rH vo co r- in in rO rH r- m m o o r- r- cM oo ιn o m τ ro o oo σι r- cM in n in cn r— n t— eyi co '- T in rH n co cn r- '- r— H O s oo cn oo cn cn rH CM H ro ro m cM r- in in vo o cM CM ^ rH n oo cΛ r- σi H CD co CM CO H rH co CM o o CM <n ιn τ vo cn τ ιn τ r- oo τ r- r- p- vo o

© ._ O i-i oo vo ro σϊ cn r- co vo vD r- oo vo r- cn cM ro ro ro ro ro r- r- in ^ ^ ro vo r- in T T -r in cn cM vo o cM CM CM O ro cM CM O cn cri oo co m T in vD r— tΛ C rO CM C CM H H H iH iH H CM CM CM CM CM C rO rO CO cn rO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CO n ' ^ T T CM C^ CM CM CM CM CM CM

H O OOO O O OOOO O OOO OOO OO OOOO OO O O O O O O OO O O O O OOOOOOOOO O O O OO OOOOO O O O O O OOOOOO OOO O OO OO OOOOOOO OOO O O O OO O O O O O OO O OOO OO OO OO OOOOO U

PM rH rH H rH _fl (n ιD H o n ω o t ^ ^ W ( m co « ιo o H v ^ M H ιn H ^ Φ W H O » ιn ω ^ ^ oo m c! m t^ι α) ι3l co ιIl ^ o ιn ^ o ol ι^ι co ^-ι ^ ιΛ ιη en cn m o ro H in rH cn r- o co cn rH ro r- ro ro rπ cn oo r- cM co co co ro ^ cM cn cM VD H r- in in H r- n en in o o cn cM H in vo ro ro rH o cTi co cn in σ3 D in H ^ -- θ oo o cD in c r cn cn ιn ιn r r- C VD ^ o o H c cM n r τ cn co m H VD ∞ cθ H in τ o oo D i r- oo cs m '- oo r o o T cn cM rH O CM CM rH O cΛ o m (^ι ω r^ ^ ( M n ^n N ^ N ^ n ^ n ιn ιo ω a ^ oo ω ιn ω ιn ι ^ ιn ^ v ιn ιo ιn ιn ^ Φ vo oo oo ^ (Jι ^B ^• ι ^•!l' CM CM CM CM CM CM CM CM H CN H iH H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM C^ CM CM H H iH iH H H H H H H H H H H H H H H H H H H H H H rH H H rH iH rH -H rH H rH rH rH rH rH rH rH rH rH rH rH rH H rH ol ^ ιη tπ ^ co ^i! ^|J) ^ ιo (!l lD o o ιn ιn o ι) (! ^t) H N O (^l (Il ^ ^ αι <ι m ^ H lB ^^ ■^1 r- ^ oo c()l ooι ιrnO rH CM CM O co T Vo r T T CM r- T O c H O C— exi cM in co vo H T H co T in vo oo r- rΛ CM O ro r- rΛ CM O co vo ro r- cΛ in exj co cn ro cn co ro cM 'T in m rH VD i-i vO i-i vD m m o o vD o cM in t— O H oo rH r— vo τ cM θ cn τ oo r- ro o oo ro cM r ι-ι vo ^j ι— cM CM f ιn m rH r- vD o oo m o τ r- <n cn vD M n σi '. r- ro rH '-ⁱ in vD c cM oo m m vo m r- r- r- oo oo cn oo ιn m ^^, 'j^, r rH rH H o o cn m ιn vD r- oo cn o θ rH vo vo vo vo m τ ro cM r- r- r- oo oo cTi o o r- CD r- VO r- VO ri d H H H H H H M N N ri H H H rl H ri H rH H H rH H H CM CM iH

CM r- o o T r- H ∞ co r H cβ in in in r- r- CM CM T in in cΛ vo o^ rH co ro oo co o cM T ro r— r— τ cn cD σι m τ r— r- cn r- oo o ^. o ^P rH ro cn o ro

CcΛn rr-- i-n10o c-n^ ^cn rr-- c_o Ccg CcMM OO OO iinn v-o> CcMM rr-- ιH H VvOo VDo rH ι-I CM Cn H r- ιn θ rH VO Cn CM Cθ rθ r- VO r- H in r- H lO rH in rH t- rH r- T r CM OO VO C rH f H CM CM vo H CM in iH r- vo m cM in i cM cn o o CM r- m cM in τ cτι c ι ». rH CM r- co oo o ^ι^ι r- τ m ^■_' ro in CM T cn o ro co H in cM vo co r— co m ro ro τ ιn vo m m τ τ ro ro vD VD r- oo cn oo [- oo r- r- vD eτι o cn o σ> O O O O H ι-I CM T ^r in cD r- r- vo oo in in m r- r- oo cn co co oo co cn cn co

VD VD VO vO VD VO VO VO VO VO VO VO VO VO VD VO VD VD VD VD VD VD VD r— co r- vo r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- f- r- r- r- r- r- r- r- r-

r r ^ ^ ^ ^ ^ ^ -T 'T T 'T 'T in in in in in in i in i in in vo iD CD CD D co o o vo r- r- r- r- r- r- r- r- r- r- r- co co co oo co oo co oo σ> cn σ> σι w o cn o^ cn cn cn σ^ cn cn cn cn cn cΛ cΛ c cτι cτι <Λ cn Λ cj> c cn cn cn

ωωωωωωωωω ω ω ω ω ω w ω w ω ω ω ω ω ia W D D D D D O D D D D a ϋ C CD C ϋ C D D D D D D D D D D D _: :_: _5 K .-: κ _- κ _: tt a --C a: χ HH HH HH HH i-H Hq H

Oι llι li aι I- ϋ llj ⁽- α( Oι αι Bι O( fc l_ _ ϋ U U U 0 U⁾ C5 U < < ^ iH J hH Hl J h4 iH >H U O U c5

Λl ffl O Q Q B W N rtJ CQ CD Q Q t-i ω si uozuuuuυϋuuuo rtj CQ CD Q W ω rtJ CQ CD Q W SJ K K ft CQ CD Q Q rt! CQ CD U O U CJ U CJ O U O O S ϋ ϋ U U O O U O o u u o z u z z υo z o o o o o cj O Z O CJ

^ oo m o H N ιη ^ ιn ^ ^ o) lL O H ^ι n ^ ιn ^ (o ol O H N (n ^ ιn ω flo Φ O ri (^ι n ^ ιn ^ ι» 010 H N n J ιn ω ^ oo m o H r^ι H H H N N N N ( N N « N N iη (η n to n n n oo t n ^ ^ *» <» *» *ι *ϊ *ϊ *-f *ϊ in iJi ι ιn ι ιn ιn ιn - ^ Φ ^ ^ _ _ ^ Φ Φ _ IO Φ ^ IO Φ Φ VO Φ Φ _ _ _ _ _ _ Φ - _ _ Φ _ _ _ _ _ _ _ _ _ Φ _ CD CD IO CD IO O

00 rH rH rH ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ © OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO o EH EH EH EH EH EH EH EH cH tH EH EH EH EH EH EH EH eH EH H H EH EH EH EH EH EH BH EH H EH EH eH EH H H H EH EH EH eH EH H EH EH EH H EH -H EH EH EH EH EH EH H rti rti rt; rt; rt: < rt; rt; rt! rt; rt; rt: ι< rt; rt; rt; rt; rt; rt; rt; rt; rt; rt; < < ι^ rt; rt; rt; rt; rt; < r^ rt: it

t- ro OO rH in m rH VD CM rH in CΛ rH rO Cn v vDc co o r- r- rH rø rH ro r- σi n ∞ ro o cM r- vD co rH r- cn cM cn ro ^i' VO in vo r- ro rH -sj M vo m co oo ^r σi cn oo r- cs ^■qi o r vo H M oo 'O' r- r- σi t- rH oo co σi ro T O i r vo cM cn N ^i' i vo c CO '-i' ii vo r- r- vo ^. σi rH τ H

© © oo cD c m in vD vo r- rH T T r cM rH o n oo cM c cM M CM M ro cn co oo oo vo oo r- r vo O rH H rH CM rH CM O CM CM CO C CM "- rH '3< C in

CM CM CM CM CM CM CM CM rO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H ooooooooooooooo. ooooooooσoooooooooooooooooooooooooooooooo U

PM ro C r-- Oo in o o H rH o ^ (^ ln ^ π o o3 oo N H ^ ' O N ^ ^ ^ ^ H ^ a ^ Φ ^ ^ ιn ^ eo o ^ ln l N ^ ι^ι ^ ri (Il ιn ιn ιn v ^ (! 010l H O ^ ι^,1 ^Cl ffι o ^c) _ r- m rH oo τ ro c— cn cn vo oo cn T o m co oi T OO co ro co cn 'a' r- co cn t— c- ro σ τ θ '-' σt CM Vo σ-ι oo co o -<3^, C in 'τ r- c> co cN in <3^, c cM co cM c o c vD rH H cO T CM H r- H n Φ _ (Λ o m » m ιn c^ι ro ^ n M ^-- n ln co <) Φ ra _ n c^ι (Λ ω Λ ω n W N Φ n ^ Φ cvl ι r>l m T T r— ω - ιn ιn ^ CD C^I fl1 <Λ m o m o H O H (I N H [l (l l») ι-I N ( f^ 'l^, ιn ι^,l ^^ l(1 ll) ri O ri O rl H H H O O IΛ CO ^ ^O • oo r— co co iH H H iH H rH H H H H H CM H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H H H H H r

CO r- O CM CO rO r- O rO VO rH i-H r- O rH Cn cO rH CM CM rH in o vo r- ro H CM (.O. r-O. T - O _O r .O . O _ O rH VO VO ro σi '-I 's. OO CM rO Cn VD T CO rH rH CM O CO in rH

VD θ CM r- o ιn cD r- '-r cn σι cM r- m m cn o τ VD vθ rH m cM en i-H H in o o ro v ιon omo rrιo-, crM.^l rt-_ r r-- rH Cθ σi r O Cn θ VO CO VO VO O CM OO rH O rH in θO Cn i cM CM rH o cM O ro cM ro o cn r- ro in cM rH ro vo cn vo cn co ^r vo r- oo rO T Co co in o cri cn r- rH OO CΛ oO VO O i-i σi CM ^' VO O r- OO CM VO rO VO CM oo r- c iH H CM r -T T '- C T T r o o ro cM rH CM ro c -T O o o n c o o o H CM CM ro oo oo vo m T in vo ro in in '- T ^' T VO CM CM rH O r-- r- ι- ∞ ∞ ∞ ra ∞ _ » ω _ ω α⁾ co co „ ro oo co oo co co ω co ro co co r-- r-- oo oo oo oo oo co oo r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r-

cn _ O -ϊ - O O O O O O H .H ιH H rH H H ιH CM r I CM CM CM CM CM CM CO cn r CO CO f r rθ C r^ cn cn cn cn cri o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o

D D D D D pS O^ή tf pS c^ή PS Z Z Z Z Z Z Z Z Z Z Z Z Z z Zz Zz αcH αPS rpx-, c_ pc; c; c- s cc; c_ cc; cc: z z z z z z z o- o^ή c_ o, . c_ ι^ cti _ j j >i j hi w iιi ω tι) u ω n oj c(ni) M n n B w κi (n n to n c ω H >H ι x x x x x x x in u) <n vi v v) u> w x

U CD O CJ C W n w crt W ^ i-^ i^ rtl rti rtl rtl rtl rtJ rtl ^ rt rtJ rtJ rtJ rtj EH EH H H EH EH Eπ H H H H H rtJ rtl rtJ rtl KC rti iC stl EH EH EH EH EH EH EH EH EH rH CM rH CM H CM

Qυ ot-l oC-l o o CQ CD tt CQ CD Q D et CQ CD Q Q < Q Q W Q ω sι _: ft CO CD O ^Q ft CQ CD CD

(J CJ o J o z O U O O Z CJ z cj υ cj o z cj o υ u u u o c o o o υ o U U U O Z U o z o CJ o υ CJ z u ft r τ ιn vo r- ∞ en o H C c τ ι _> r- oo σ θ H C ^ ιn vo t- ∞ <y> θ H CM co -*- ιn

^ r- ι- r~ ^ t- > ∞ ω ∞ ω ω » ω ω ω _ CΛ n σι θ^ cΛ CΛ crι n σι i3i o o o o o o o o o o H H H H H H H H H H cι cM ci N (N Cv) (sι r (M φ φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ r^« [-- r- ι^ r^ c^ rⁱ i^ ι r- ι--- - r^,' i-" r" i~ h r ι ι^ r- ι^ ι r-- ι-- r~ r r- r- oo rH

ΣoΣoΣoΣoΣoΣooΣΣoΣooΣΣoΣooΣoΣΣooΣΣ H Eo Σ Σ HoΣΣ HoHoEHoΣ HoΣ EHoHoΣ EHoΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ

EH H EH EH tH EH EH EH EH EH EH EH EH EH EH E HoHoEHoEHoEHoEHoEH EoH EoH EoHoEHoEHoH EoHoEH EoH foHoEH EoH EoH EoH EoH EoHoHoEH EoHoEHoHoEHoEH EoHoEH o f tt f ft f tt f f t f tt ft ft f f t t t ft ft f f f f t fC t f f ft t & f^ it

rt t- ro H r- ιn ro c» r- oo cn co o ιn vo r H VD ^ r- ro ro σ^ o H CD ro σ> ro oo o ιn cM CM cn '5. oo vo co rH O cn cM in cM cn sji oo r- vo o ro ro oo o σi cM O rH S •T O vo H iH r cM O r- vo vo cπ iH T CD eTi σ'i T in r- CM CTi c cD o in cri H ^ r- 'T co r— cM o ro cM oo ro cn m oo cD o o ro ro o cn ro ro r- CM r- CM m

© -Si o _s ^ ιo ln ιn _'. ι^, N ^ oo Λ O H (l N N H H H H n N ιη ιη ( '» n ιn Φ ιn Φ ln ιn ^ ιo ^ ^ » _ co oD co ol o ^ ιJl 0 ^s cc) 0 H H H H H H iH CM CM CM ro ro ro ro co ro ro ro ro c^ co ro ro ro ro c ro ro ro ro ro ro c ro ro ro c co M "j' *^y ^3* *^r *_*r

H OOOOOOOOO OOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOO OOOOOOOOOO OOOOOOOOO OOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOO oooooooooo

PM H H ri d rH rH ro oo cM ro o r- m cM σι cΛ o ro oo o τ m ro n ιn r- r- vθ H rH CTl rH rO rO i-i m m O T O Cn oO O O T H in H r- vo ro r- ro o co ro H cn cn m ιn r- cyι r- oo ιn H H τ r- '-r ro r- vo r H σi O T r- CM H ro rH cn co cM oo in iTi H ro r- oo r- ro CM T ro cn H T in r- o vD o cn cM ro rH H r- r- oo ro oo m oo in σi σi o σi vo r- r- oo cM r— cM in T Vo m oo oo vo ro cn ro i-H en

O H N f H N rn 'i' Λ fl iJi m βi co co o o o H m o αi oo Kno co cD Oi O H f oo ci iino . σi cn oo r- r- vo co Ln vo vo vo m '- co ro ro CM ro ro

CM CM CM CN CM l CM CM H H H H H H H CM CM CM CM i-H CM rH rH H H H rH rH CM CM CM CM CM CM CM CM H H rH rH H rH rH H rH rH H H iH H rH rH rH rH i H H rH H rH i-H rH iH rH rH H rH rH H H rH rH H rH H H rH i-I H H H rH rH H rH rH i-I H rH rH H

T H CO CO VO CM ΓO Γ- CM τ ro vo τ ιn H τ ιn τ ιn ro D r- rH 'τ c ro cn rθ H r- H τ ro m r- rH ro σ> <!P i— H C in r- o cM oo vo ro r T in r— CTI T Γ— oo r r—— c σι c coo o o o o T T o o rr—- oo mcQ vVOO T'-' C CMM H H H rH C C CMMM iinn rr»- CM VD r- VD in CM VD H VD OO H T t— ιn ιn ro o τ cM θ r- CM in CΛ oo vo ι- in o CM co en T cM ro o cn ro vo CM O CM O rH c cnri H θ Vθ τ m τ-ι o ro cM τ vo cD r- cn O O H H CM CM CM r- r- in τ r C H rH O Cn c τ *5|i ^. 1' r r C H N H rH O O H rH O rH O σi rH O H O O O Cn σi OO O O rH H O O CM CM CM CM CM CM CM CM CM iH rH rH H rH H rH rH rH H rH rH H rH rH H H H rH H H H rH H rH rH

N ιcι 1»

0\ cn m cn o H O H iL ⁽ii ⁽i⁽ w o o H H O ⁽⁾i H fl0 iri in ^ in ic ^ 7 M i0 H O H m n ( (i N H (ii i» ^ fl n <t <iⁱ N N O N H o Φ Φ Φ co [- ^ ^ r-• ^ r- ^ ^ ^ ^ Φ Φ Φ Φ Φ Φ vo Φ -ι Φ Φ Φ ι ) ιn ιrι ιr) Φ Φ Φ Φ ^-

Φ Φ Φ Φ ιo ^ [-^« ^ ^ ^ ^ ^ r- cD a5 _ _ ω _ -l (Λ m ol σl m (Jl σl Ol σl n o o o o o o o o o H H

os cc. tf o_ ⁽_; _^{, p,} c^t; ι_; ^β, cD C D ϋ o o o u o ϋ tf >i X X >* χ >i >i >ⁱ χ χ c c ci ai cύ & ei f£ Bi cύ o4 u a a tt ω u ul pti o6 c6 oi oi

^ Λ| rti < n n tO C t⁽i n < ^ S <; «; fl! <; J i iH iH ^ >H >H iH tH H tH H h tH H H H tH

H H CM CM H CM H CM H H CM CM

_ O Q _ Q U N _ < (B U Q U N S S rt, CQ CD rtJ CQ CD Q Dd Sl ffi -C HS CQ CD Q W SJ υ o u u cj u υ o υ o z rti c^Q CD a ω a w i

CJ O CJ U Z U Z Z O O Z CJ CJ O CJ o z CJ CJ CJ CJ Z CJ Z Z CJ O Z CJ CJ CJ O O Z CJ O Z CJ CJ U U CJ O U O

⁽^ O H l M fl ln w ^ oo ⁽Il O H ι r ^ ιn ιlι a) Ol O H ^ ιn v ιn ω o> Ol O H N n ^ ln * ^ co ι! O H (! ιη ^ ιn ω ^ os ι) O H N («l fl'

C M f r ro r ro r r r to ^ ^ T 'T T ^ ^ '^ 'T '^ in in i i i i i i i i vD VD vo o o vD vD D o vD r- r- r- r- r- r— r— r- r— r- r— r— r- r- r- r- c— r- r- r- r- r- r— r- r- r- t— r— r- r- r- r— r- r- r- r- r- r- t— r- r- r- r- r— r- r- r- r- r- r— r- t— t— r— r- r—

— rH ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ∑∑∑∑∑∑ © ooooooooooooooooooooo Σ Σ Σ Σ Σ Σ Σ Σ ΣΣΣΣΣΣΣΣΣΣΣΣ ΣΣΣΣΣΣΣΣΣΣ Σ Σ Σ Σ Σ

O O O O O O O O O O O O O O O O O O

EH EH EH H H EH EH EH H EH EH EH E_H EH E_H E_H E_H H E_H E_H IH EH O O O O O o H EH EH EH H H EH H OOOOOOOOOOOO t f ft fζ ^ ft e f fZ f t t t f ft f ft ft f ft ft < ft ft ft ft ft ft ft tt tt ft ft ft ft ft ft ft < tt ft < ft tt tt ft tt ft ft ft ft ft ft ft it

oo ro o ro o o vo r- m oo rH 's' r- CM cn o r- oo oo T CM cn vo vD CM ro vD Ln ro ro m oo r- o o m vD ro H cΛ σi oo cM ro rH o cTi o σi H ro T ro ro ro ro cM CM CM co ro ro co cM ro cM ro ro ooooooooooooooooo ooooooooooooooooo cn CM vo oo r- vo ω oo H to ιn CM CM en vo r- σ> e rnr> rr—- i-nn i von VD r- ro r- ro r- r- ro ^■<- rH H oo

CM in T co r- r- vo oo vo r- ιn

H H H H rH H H H m en co m vo ro vo vo r- CM ro in rH m r- co o H oo ιn r- ιn '- oo m ro cn vo oΛ '- CM cn o cM in oo <Λ o cM OO in CΛ rH CO m VD in O in VD i-H in OO O T rH <Λ ιH CΛ CM ro vD m σι oo ιn τ vθ rH r- ^r rH r co in n r r H co «3i cn r- r- T O ^i^, r co cn in rH m r H OO CM VD VD in r- '- rH VD r— CM CM CO VO t— --ⁱ r- cΛ ι-ι r- rθ H r- r- τ cM CM τ ιn m '- cΛ CM OO H ^ i-r cM CM Oo m oo r- ro ro cM H ro T r- in in in in in m ^ι r- oo vo σ> vo o <Λ vo m ro o θ rH CM θ H o CΛ cn r- τ τ ιn vo vo ιn '- ro ιn τ ro cM r- r- oo cΛ o cM CΛ o θ H CM H ro ro τ m ιn r— T CM VD r- r- CM VD CM VD O 1< CΛ CM r- in .r- O _ r.H. C-Λ. o.o_ o_ r.o. c.M. O_ _ . . CΛ in rH . C_n. C.M. I.— Γ .O. O_ C.M. T- O VO O OO rO O CM VD VO CM H rH rH in ro . r- vo ιn o ιn vD ro τ H θ ιH rH 'τ rroo vvDo ιmn fro ccΛΛ rroo vvoo rr-- θO LLnn o oooo vvDo c roo rr-- L inn cCΛΛ τT c CΛΛ VVDD HH θO OO H CΛ T τ t- o cn vo cM vo o r- oo o en M T T r- rH oo oo c in m vo Mi c o ro r— H vo ro oo rH vo rH ro m cn r- CM cn o r- CM σι oo in r- VD H T T T T in in ro cM CO rH

OO VD VD VD Γ- Γ- Γ- VO OO CΛ OO O O O rH tΛ tΛ oo oo r- r- in Λ ∞ vo ^ in w ^ o o rH CM r ro r r 'T 'T Oϊ cn cΛ cΛ oo co r- O rH O H CM rH o c C ιn vθ Φ Φ Φ Φ Φ Φ W r. r- ^ ^ Φ Φ Φ Φ Φ Φ Φ ^ r- t-- ^ ^■- ^ ^ ^ Φ Φ Φ Φ ^ ^- • ^ ^ r- t-^• r- r•

H H HN NN(^ι M l\ Nn π c^ M ι^η fl ^•J *» ^■» *» ^■ϊ v fl « ^« ^ ^^ v ln ul ιn ιfl ιn ι ι'l ιfl ιn ιΛιnln ww Φ Wtf ΦW ^ ^ ^ (D „

H H ιH ιH H H H H H H H H H H H rH ι-H H H H H H rH rH H H H rH H rH rH H H rH rH rH rH ι-H rH *H H rH H H H rH H H rH ι-I H H *--l rH rH rH H H H H H H H H H iH H H H H H iH H H H H H H H H H H H H H H H H H H H H H H H H iH H H H H H rH H rH rH i-H rH H i-l H

X ft CQ CD CD tt co CD rti m cD Q ω ω α ω i si α. CD o υ o z CJ CJ o υ CJ o z o υ o u o z u o υ υ υ o υ z υ cj c o o z suC CuQ CuDuQυtdυQuWuSl Eoquoz rtϋ! CuQuu CDυo ft CQ ft z υ u υ o z υ ιn ω ^ ro <n o H ⁽ι n ^ ln ιc ^ m m o H t^ι n « ιn ιo D <⁾l O H N ιη ^ ιn ω ^ ∞ fll O H N ιη ^ ^n ω ^ (. cιl O H N t fl ιrl l() oo o o

_ ffl OO Oθ ra Φ Oi m m m ffl <J> Φ IS (!l O O O O O O O O O O H H H H H H H H H H N N N ( ( N N N N N n f) n n r IO I»l l<l lΛ iη _'J r- c— r— r— r-r- r-r-r— r-r— r-r—r- ^Φ„ _ooα>oomooooαoα>m _ αom_ „ - _ _ _m__coαoco(i>coαιαι )θ}(iιccιθ3cooDθoαιαo

oΣΣo Σ

EH EHoΣΣ Ho ΣΣ EHoΣΣ EHoΣ EH EoH EoHoΣΣ ΣΣ EHoEHoEHoΣ HoEHoEHoΣΣ EHoEHoΣΣ HoHo Σ ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ EHoΣ HoΣ EHoEHoEHoEHoEHoHoEHoHoEHoEHoHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoHoEHoHoEHoEHoEHoEHoEHoEHoHoEH o tt ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft t^

rt VO rt t- ro in O rH OO T CM CM CM T '-J' m in O Cn cn O CO T CO r- rH rH r- T 00 CΛ C0 00 00 CΛ VO C0 r— o CM r- co in ro r- ro vo co r- r- oo <Λ CM CM oo vo oo es H rH rH CM Cn τ CM rH CM r- rH 00 in T VD f 1^, VO 00 T CM VD H OO CM VD T CM CΛ CΛ CO O in T CM r- oo ro vo i— ro r-t in ro O T r- ro cM CM T VD vo vD

© © H CΛ CΛ Cn ^r τ r- CΛ CΛ CΛ H CM CO O H H CM CM C rθ rθ 'J^l VD ιn r r rθ CM H CM r CM CM H rH O O H H CO VO CΛ CM rH O O CΛ CO '- CM rH O CM rH O O CΛ r M C ro ro ro r ro τ 'T P ^ τ ^ τ ^ ^ τ τ *τ ^,τ ^ ^ ^ ^ ^ '^ ^ ^ τ '-- ^,. *- ^,>- *-- τ τ τ τ m ιn τ τ ro ro ro ro ro co ro ro ro ro

O O O O O O O O O O O OO O O O OOOOO OOO OO O O O O O OO O O O OOO OOO OOOOO OOOOO OOO O

H υ O O O O OO O O O O O OO O O OO OOOO OOO OO O OO O O OO O O O OOO OOO OOOOO OOOOO OOO O

PM H H rH H H H H rH H rH H H H H H H rH rH H rH rH H rH H H rH rH rH H H rH H H H H H H H rH H rH rH H H rH rH rH H rH rH iH rH rH rH rH rH r- τ vo cM CM t- ιn r- cM θo r- τ vo σι τ vo oo θ H in cΛ ^ . Λ in oo vo in cη in oo H o in j m vo r- o rΛ H CM co oo cM r- ro ro n oo cM in in T 'T r- oo T T oo H in c T in r- cM t— ro o oo r- cM o m cM in o OoO TT Γ r-- vvDD rco ιmn vvDD τ^r σc> rH θo ττ cCMM C<ΛΛ ττ ττ ceΛn rr—— r roo mm τ c CMM τ ro cΛ ^ cM cn τ o oo «-j^ι o m iH O CO rH rO r- H rH r- T Cn cM rH rO H VD OO in H CΛ VD eo cΛ o cn in r— ^■w r— c— in o r- in T rH i— ID CM ^ o in ro τ r- τ H H ro ιn H ro ιn vo

(^ι m ιo _!! O O Ol o3 ^0 1r » v_J eo <^ ^ ^ ^ Φ ιn ^ ^ 9 ι ^ Φ « α) ^J 1J (O ^ ^- co a) (n ^ ^ lI) lΛ v n ^•^ (I) (» os (l10 σι co r- en co r- vo

-H H _rH H i-H rH O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O i-H O O O o o o o rH rH rH H H rH rH rH rH H rH rH rH H rH rH rH H ι-l ιH H rH H H H H rH rH H τ-l rH H rH ι-H H H rH H H rH H rH rH H H H H H H cn oo cM cn cn o vo cM oo vo ιn ro τ cM τ cM CM O T OO r- rO VO rO T rH t— T rO CM in CM rH rH OO cD CM oo oo r- oo o co r- c ro r- vD <n rH rH CM o cM T CΛ in in co o r- cΛ in rH ro H r- vo co r-

T VO OO VD rH r- VO VD VD oo r- in cM r- o T CΛ H co o vo r- '3' r- τ_ o r- CM oo r- ro τ o cΛ ιn vD VD r- vD in τ ιn ιn ιn OO O i-I O O O O OO OO r- CΛ OO t— CΛ VO CO CO '-. . CO CM CM T 'a' CM CM

CM CM CM CM CM CM CM CM CM N rθ iη n n π n r4 PJ ( | CV| V| N CVl CV| CVl C| C| N V| l C\| N I N o n o n ώ c^l H m m o w o a> r α! n «ι π ιn v J o m ιη N ^ H « '» «) ^l H l^,l 01 o ^ H N ^ v o o o ^O H <ι^| H fl lf) (Λ ι/l H (I) H Ol ^ι ^o ^ ιn n ln w co ^ ιn ^ ^ ω ^ v « m „ o o1 H ^ σι ^ _ _ Ol ^ ^ H <^ oo ιn ^ ^ m (^ι ιn ^ (Λ O ^ a) o ^D tO '» o n N tD l£ι o ^l⁾ ^£ι ι H oo cΛ vo ro τ o o - vo vo ιn cM oθ '- θ r- cM vo m o cM H in H r- _^ cM r- r- ro o ro ∞ r- 'τ ιn τ cM i^ vθ H VD CM in r- ιn oo ιn τ ιn ιn cM ιH ro ro cM θ o σι ro τ ro ^r ro cM CM H o. T 'r co co ao co aj cΛ O H O vo vo ^ 'T cη c T C CM C H O cn o cn ∞ ∞ aj co r- a^ o co co r— vo vo ιn ιn τ τ ro

^ ^ φ ^ r- ^ r- ^ - ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ a) (_ ω - ^ ι-- ^ r- r- r- ^ ^ Φ r-- Φ Φ Φ ^ Φ Φ Φ Φ

a) m flo _ _ a⁾ _ <ιι ιιi ⁽n m o\ σi ⁽Λ ^(jι o o o o o o o o o o θ H ri H H H H H i\i N N N i^,ι ι»i ( n n « n 'n n v 9 ^ » ^ v ^ ^ ^ v

H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CN CM CM H H rH rH H H rH rH H H H H H H H rH H rH H H rH rH H rH H rH rH iH H rH rH H H H H rH rH H H rH rH rH rH rH H H rH H rH H rH rH H rH rH H

D D D D D D C_ W W n c_ W cn cθ O O C O O ϋ CD CD C Cή θc: c_ C≤ C_ C_ C_ >H tt n iύ w ω ω x x x x x x x x x ai cιi t< & cιi c6 ύ cιi ai & c6 x ai n x x x

H-t H^ J H^ HH HP HH H^ HH HH HH HH HH HH H rtJ rtl rtl rtJ rtl rtl rtJ rtJ rti rtl rtl ^ EH H H EH H H D a O U C O U C C U

H CM H CM H CM CQ CD ^{Q Q} tt co CD a ω t_ < ffl U Q W N X ft CQ CD CD rt; t co o Q ω a ffl ⁽i) D U Q W N _l u uυuu z c o oo o z υ o o u CJ υ z o Z Z CJ O Z O CJ O CJ CJ O Z u υ o z u u u u o z oozuoooououo ffl ι3l O H N M ω ωcΛcnw cΛ

ΣooΣΣoΣooΣoΣΣoΣooΣoΣΣooΣΣoΣoΣoΣoΣooΣΣooΣoΣΣoΣooΣ Σo Σ ΣΣ ΣΣΣ ΣΣΣΣΣΣ H oEHoΣ EHoΣΣ H EoHoΣ EH oΣ EHoΣ EHoEHoEH oΣ EHoEHoEHoΣ EHoEHoEHoEHoEHoHoEHoEH o ft ft ft ft ft ft ft ft ft ft ft ft ft tt ft ft ft ft ft ft ft ft ft ft rt; rt; rt; rt; rt; rt; rt; rt; rt; rti rt; rt; rt! rt; rt;

ro o m oo r- r- ιn cΛ vo r- CΛ CM CΛ o co cΛ CM ro ^,=, r- ro i— ro oo H H T o r- CM oo ro oo in oo m cn o in oo H cM T in ro cΛ cn cΛ in r— i-H oo m cn cn r-

CM -Si ro tΛ H in co cM oo o o o σi oo ^i' vo oo in H m τ H CM ro r- r- r- σι co r- CM CΛ O in oo c rH vo m co co ro cD '-i' in o m r- o m vo in in in cD oo

© ><s

O .a <Λ CΛ (Λ r- ιn τ ro ro cM cx5 r- oo <Λ oo r- r- cD CΛ CΛ θ CM co c ro ro co cM rθ '3' '. ιn vo cM in r- r- ΓO CM CM CM ΓO CM CM CM CM I-H O O O o o

CΛ f*l r ro r r ro r ro r r ro r r ro r r ro c ro m -T ^ *^ ^ ^ ^ ' ^ r '^ T ^,-- 'T in in in in •T T

-= OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO υ

PM H rH rH rH rH H H rH rH rH rH H H H ri H r- VD OO H CM CO CM in r- ∞ O in CΛ VD r- H rH T CM T CΛ rH r- OO OO OO CO rO T VD r- cM oo cM VO vD H in vo oo vo σi ro H cn in cM r- CM CM T in cΛ o in H _ T i.n_ T__ rH . i.n_ , c_n . ID„ o_ in o _O __O C _n . C .M . _OO O H CM CM CO VD O CM m rH m r- VD CM rH — ' cn ro o r- m r- T O VD T CM H cn vo rH T Oo ro ro cΛ CM O co ro o T CM en rH T oo CM oo H ro in cM ro o o o r ι-ι ro cM m oo τ vD τ r- o ιn cM r- r- rH ro ro T oo vo rH CM T i— H CD ro T oo oo cn r- in oo o oo vD in r- oo oo oo r- co r- oo oo cn r- r- co m τ vo oo oo (Λ θ cn cn oo r- vD in r- co r- vo m in T ro r— r— eΛ O rH rH rH O O rH H CM CM rO rO '- in T ^r m o o o o o o o o o o o o o o o o o O rH O O O O O O O O O O O O o o o o o

CM VD T VO r— rH CO OO O CM T OO t— O O H r- τ r l— VO CΛ VD O H VO rO OO H H in cΛ rH T CΛ H T OO CM VD VO Cn CΛ VO r- in CM CΛ rO OO T CΛ OO - CO T oo vD θ ro cM *τ cM cn ro θ H oo cD in cn r- 'τ vo r- rθ Ln o c oo eΛ τ o c» θ H H -τ r- ιn θ 'τ D 'τ τ iΛ eΛ CΛ ιn H C i^ r- o vo ι . ^ _ι τ <Λ ro ^ vo τ co r τ 'τ τ o o o c T 'τ c H co _> r~ θ >i ιn ιH (-o ι τ -^ n ^J- CM rH H CΛ CΛ O CΛ O CΛ Cn oO r- oo r- oo r- r- r- co ^i' T T ro rO T ro cM T in vo r- oo cn cn m m in in co m r- T CO T ro T in ro H ro H H T in rH H H H rH rH H H H rH H H rH H H i-H H H rH H H H H co r- vo T T oo vo o cM ro oo co o in cM rO T CΛ H cn ro ro o vo T oo o cM cn o H r- rH cM in rH in cM o m H ro m ro o oo cΛ vo in r- co vo o in vo rH •T Vo en o -i rO H c ^ ^ ^ αs r- vo H H cΛ ^ 'T Vo oo r- co vD oo T in cΛ H rH oo H co ^■ ι—-» " m-^> t- ^-t> c H m vo vo vo τ ι- CM Vo r ι vo c CM H r m rO '- co cM vo rH m m cΛ ro H oo o oo r- m T VD oo cΛ T O H ro oo oo in cM oo r- o r- o m ιn r- oi rH τ ro τ τ r- H oo cM H H Vθ ιn o m tΛ vo r- o ccnn ccΛΛ CCΛΛ θθ HH CCMM CCθθ ττ ιιnn ccnΛ ccΛΛ oooo oooo rr-- vvDD VVDD ιιnn oooo σσιι rr-- oooo σσιι oo oo oo r- r- o o o CM H ro cM ro T CM 'sr cM co cM rH rH ^i ro in vD r- r- r- r- oo oo r- cn o vD VD vD r- r- r- r- r- r- -vo- -vD- -vD- V^■D- V^■D- ^■vo- vo- ^■vD- ^■vo- v^■o- ^•vo- ^■vD- v^■o- r- - co vo vo r- t- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r-- r- r- r- eo

-τ ^ ιn ιn -i ιn _-ι ιn ιn -l ιn vo vo vo vD VD Vo vo vo r- r- r- r- co co co co co co cn cn eΛ eΛ CΛ m

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rO rO r^

H rH H H rH H H rH H H rH H H H H rH H H H H H H rH H H i-H H H i-I H H rH H H H H H H H H r-I H H i-l T-I H H H H H H rH H H H H tf l- n w n ω co n W M C D D D D C D D D x cύc oύ, , ρ5 ρή ρ, w co w c c_ c o ρJ c-i oή cr; o- _ c-; >H H >H >H θ O O O O O O

HIx_HI xHIx_HI U ω - c a ^■ύ- c ω ^■ύ- cύ ω x x x x x x rΑ ri rΑ r cύ eύ eύ cύ oi Bi ai CD CD CD CD CO W B W tll M J J J J J J J iH r1 EH fH H h H H H U O O - l- (- (lι l- (lι l- _ tt CQ CD Q ω i tt CQ CD a Q ft PQ CD ft D- CD Q W J ft CQ CD CD rt; D

CJ O Z O CJ CJ CJ O Z u o z U U U O U U O CJ CJ o uuouo Z O J J CJ u z o o z cjcjouoo z υ cjo z υ o ft oQ o CD o o

^ ω _ O H N ιη ^ ιn » ^ ω _ O H N ⁽n '» ιn ω ^ co Ol O H N M « ιn ω ^ m Λ O H N fl « ι ω ^ (D m O H (l f^ ^ ιn Φ ^ (O ffι o ^-| [!

CΛ CΛ CΛ O O O O O O O O O O H H H H H H H H H H CM CM CM CM CM CM CN CM CM CM rO ro rO rO rO rO n rO CO rO T ^ 'T T 'T T T 'T ^ -T in in in CXJ OO CB CΛ CΛ CΛ Cn cΛ CΛ CΛ CΛ O^ CΛ CΛ CΛ Cn cΛ CΛ CΛ CΛ CΛ CΛ O^ Cn cn cΛ CΛ CΛ Cn Cn CΛ σ^ σ^ CΛ CΛ Cn iΛ CΛ cn Λ

ΣoΣoΣooΣΣoΣoΣooΣΣooΣoΣΣooΣoΣoΣΣoΣoΣooΣΣoΣooΣΣooΣoΣΣooΣΣoΣooΣoΣΣoΣooΣΣoΣooΣΣoΣoΣooΣoΣoΣoΣΣooΣoΣΣooΣΣoΣoΣoΣooΣoΣoΣ

O f t t f f ft ft l t t f ft t t ft tt t ft ft t ft f£ ft t fZ fi f ft f^

rt t- ro in O O CO H O CΛ O OO O H T CΛ r- CM H T Cn m vo o H H CΛ oo ro oo o ro in r- O T O CM CO T H cn co H T T Oo ro co cM r- r- CM r- cn vo co JS •5j ^ιι r- m o ro vD o ^< '!i' Co c r- r-- ^^| CM rH oo (Λ CΛ O O CΛ H CM O CΛ CΛ 00 VD r- co ro oo n cΛ oo in ro oo o ro oo cM cn cD oo r- o m in CM oo o o o __ O O CΛ CΛ CΛ OO OO O O O O r— t— in T vo r- CM CM CM o cn o H CΛ co oo oo co co r- co m ^p o r- i^ ^ ^ tn c CM N ro fi o ^ ^ in ^ -!!¹

T T CO ro ro ro rO T T --¹ -, ro ro ro ro ro T CO ΓO ΓO CO CM ΓO ΓO CM CM CM CM CM CM CM CM CM CM CM H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM

H oooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooo U 0- H iH i-H H H H H rH rH H rH H i-H H rH rH

CM CM O O VD VD H CM in < in H < ^ 03 O CM H in V0 VD CM rH r- CΛ in CM CD θ O t~ C CM VD 0000 C» r0 CM CM ^ 00 t^ r0 V0 ^•ji [— <Λ rH (Λ 00 r- 00 H T O

H co o o o ui ro o in in cM ro c ^ Λ cβ cN -T VO H Vo ^ vD co r- in r- cM co o o ^ t- cM VD H r- o O 'i' O r- NCM rM- inH Φ in o f in ∞ ij o n n o ιn c αD _VD ιn o τ H o ιn ro o c ^ CM in ιn o o cM r cvi ^ _'T H Vθ θ ( co ι r vo oo r- co co o o vo ∞ _'<- «Hi r r-- cvDo _Hι C c c i^, Λ H *<- in ro r- o ro ro CM CM CM CM H o en en cn ro T CM rO CM CM CM CM rH rO '"- i-H ro ^••- ^•>- m in '. in in vo r- vD oo oo r- r- OO CD r- CΛ O O OO OO ∞ VD r- VD rH CM rH r H o o o rH H H rH H H CM CM rH H H H H H CM CM CM CM rH H H H H rH H H H H w - co o '» H

T T CD r- VD OO t^- t- r- r- in cn CΛ O rH CM CM rO CM H CM r H CM i-I H CM O O OO C0O0 C000 C0 O O H H CM O H θi c) Mi ( '!i^, '» w C) i n ιn ^ ^' ^ vo _ H H H rH H H H H rH H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H H H CM CM CM CM CM CM CM iH CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM

T T O co vD o^ o cn o ro oo vo H CM VD r- fO oo r- co ■5T VD θ H VD H C θ cΛ C in co cn cΛ c» co r- r ιn rH co ιn o cn '<3i rθ rH '-i' r- oo r- r- θ rH θ H CM CΛ T Oo r- o cM in m o r- ro co ro r- vo rH r- T sji cn cθ H τ co ro ro cn <Λ r- r- ro H CΛ H θ (Λ o cΛ ιn cM Vθ H oo vo ιn vo cM θo cM θo ιn o ro oo vo τ ιn ro cM θ r- ro cM co H τ r- τ o o cΛ τ cM r- o VD τ oo ^ιι t— vo r- cΛ H CM in r- cΛ m oo oo CM oo in o H Vo r— O T CΛ CM rH r- in H o o ro o m

O H H N O (Tl ffl ffl lβ w ^o σl m o o o N PO v ln <B CD Φ _ ιn 9 ιn ιn Λ ^ Φ _ ^ w ffl <) H m Φ Φ « ln n n n cι N (^l rι VO VO VD VO _ ω ∞ ∞ co ι- ^ ^ ^ ^ ^ r-- ω ω » _ ω ∞ ω ^ ^ ^ [- - ^ ^ ^ r- ^ ^ ι-- ^ ι- ^ ^ ^ ^ ro ^ ^ ^ ^ ^ ^ ι- ^ ^- ι r-—-• r t—-- r r--• r— r- r- r-

ro ro ro ro τ τ τ τ -τ -τ 'τ τ *-ⁱ ιn ιn ιn ιn ιn ιn ιn ιn ιn vD vo vD VD vD r- r- r- r- r- r- r- r- oo oo oo oo oo oo oo oo Λ cΛ cΛ eΛ cΛ cΛ cΛ cΛ cΛ cΛ cΛ o o co ro co co n ro ro ro co ro ro ro ro ro n ro ro ro ro ro ro ro ro ro ro n ro c ro ro n ro n r^

H H rH H H H H H i-H H H H rH H H H H H rH rH rH H H H H H H H i-H rH H H H i-H rH H H H rH rH rH H rH rH H H H rH rH H rH rH H H H rH

> >^HH >^Hn ^{H H} Zz Zz Z3 Zz Za Z2 Zz Zz zz cco cwo cwo cwo cwo cwo cw cOT cWo rtrtj: rtrti; rt<l rtrtjl rt<; w w w pJ ^ ^ ^l bH bH ^ ^ H J HH HH HH J ^" JωwωJωJωJwwJωDUDI-DUDDM MDDMDwSωSωS SωωSωXωX SωωS Sω a.:ωS xDI ωll ID ωl]

O O O O CD O U U C O O O O Hq H^ H^ H^ H^ H^ H^ H^ H^ rtj ^ l^ rtl ^ H H H H H H Hj Ha Hq i-l l^ H^ ^

H CM CM H H H CM H CM rH CM tt aι i5 Q ω ω a o a w N tt m ca CD CD a SC CQ CD Q Q rtrtil oOQQ CCDD aQ aQ wW ωω ssii ft

Z U U O Z CJ O CJ CJ O Z O O Z CJ U CJ O CJ Z CJ O Z O CJ O O Z CJ CJ CJ CJ CJ CJ O Z O CJ U U O CJ O Z CcJj CcJ Uu Oo Uυ Uυ Ucj CcJj cj o z o rO T in vo t— oo ^ O H CM r ^ in vD r- rxi cΛ O H CM r ^. i vD r- oo cΛ O H CM ro ^ in cD r- oo cn o H C ro ^j' in vo r- cD cn o rH CM ro ^ji in vo r- co ιn ιn ιn ι ιn ln ln Φ Φ Φ Φ Φ ^ ^ ^ ^ ^ ^ ^ ^ ^ _ oo ω ω » ω ω ω ω ω m cIl CI cn Il Λ σι σι σι σl O o o o o o o o o

<Λ O e C CΛ Λ Λ CΛ n cΛ CΛ CΛ CΛ C C CΛ C CΛ CΛ C C C CΛ C C c C C CΛ eΛ CΛ CΛ CΛ CΛ C C CΛ C Cn e^

00

VO rH rH Σ Σ Σ

9 O Σ Σ Σ Σ Σ Σ Σ Σ o o o o o o Σ Σ o o o O EH EH EH EH EH EH H EH oEH EH OEH o rt. < ft • f_t Ή ft < ft < < ft <

Table 6

ATOM 1009 CB LEU 140 77 .732 27. .720 122, .767 1, .00 23, .49

ATOM 1010 CG LEU 140 78 .316 28, .286 124. .056 1, .00 24. .43

ATOM 1011 CDl LEU 140 78 .869 27. .149 124. .901 1, .00 24 .94

ATOM 1012 CD2 LEU 140 79 .403 29. .293 123. .725 1, .00 25. .05

ATOM 1013 C LEU 140 75 .442 27, .528 123, .696 1 .00 23. .97

ATOM 1014 O LEU 140 74 .984 28. .559 123. .218 1, .00 24. .09

ATOM 1015 N PRO 141 74 .972 27 .012 124. .835 1, .00 25, .23

ATOM 1016 CD PRO 141 75 .348 25. .765 125. .523 1, .00 26, .10

ATOM 1017 CA PRO 141 73 .893 27 .692 125, .550 1, .00 24 .64

ATOM 1018 CB PRO 141 73 .431 26, .642 126. .546 1. .00 24. .01

ATOM 1019 CG PRO 141 74 .697 25, .950 126. .879 1, .00 25, .83

ATOM 1020 C PRO 141 74 .411 28 .940 126, .225 1, .00 24, .54

ATOM 1021 O PRO 141 75 .468 28, .921 126, .840 1, .00 24, .16

ATOM 1022 N MET 142 73 .656 30, .023 126. .095 1. .00 25 .83

ATOM 1023 CA MET 142 74, .021 31, .302 126, .684 1. .00 26, .94

ATOM 1024 CB MET 142 74. .467 32, .259 125, .590 1. .00 26. .73

ATOM 1025 CG MET 142 75 .681 31, .797 124, .828 1. .00 26. .52

ATOM 1026 SD MET 142 75 .825 32, .695 123, .291 1. .00 28. .68

ATOM 1027 CE MET 142 76, .028 34, .375 123. .889 1. .00 30. .05

ATOM 1028 C MET 142 72, .841 31, .898 127, .439 1. .00 28, .78

ATOM 1029 O MET 142 71, .691 31, .797 127, .008 1, .00 30, .16

ATOM 1030 N SER 143 73. .144 32, .533 128, .561 1, .00 30, .18

ATOM 1031 CA SER 143 72, .141 33. .137 129. .428 1. .00 31, .33

ATOM 1032 CB SER 143 72, .815 33. .782 130, .635 1, .00 33, .94

ATOM 1033 OG SER 143 73, .513 34, .964 130, ,241 1. .00 34, .85

ATOM 1034 C SER 143 71, .316 34, .201 128, ,753 1, .00 32, .07

ATOM 1035 0 SER 143 71, .709 34, .760 127. .723 1, .00 33, .01

ATOM 1036 N ALA 144 70, .184 34, ,504 129. .378 1. .00 32, .11

ATOM 1037 CA ALA 144 69. .272 35. .514 128. ,877 1, ,00 33, .33

ATOM 1038 CB ALA 144 68. .459 34. .950 127, ,712 1, .00 31, .68

ATOM 1039 C ALA 144 68. .354 35, .953 130. ,012 1. ,00 33, .81

ATOM 1040 O ALA 144 68. .722 36, .947 130. ,676 1. ,00 35. .06

ATOM 1041 CB HIS 1016 101, .518 8, .804 140. .892 1. .00 59, .01

ATOM 1042 CG HIS 1016 101, .606 8. .263 142. .280 1, .00 61, .41

ATOM 1043 CD2 HIS 1016 101, .132 7. .115 142. .818 1. .00 62, .71

ATOM 1044 ND1 HIS 1016 102, .190 8. ,962 143. ,315 1. ,00 61. ,90

ATOM 1045 CEl HIS 1016 102. .065 8. ,269 144. ,433 1. ,00 63, ,14

ATOM 1046 NE2 HIS 1016 101, .428 7, .145 144. ,159 1. ,00 63. ,99

ATOM 1047 C HIS 1016 101. .836 11. .252 141. ,291 1. ,00 57. ,42

ATOM 1048 O HIS 1016 102. ,845 11. ,510 140. ,626 1. ,00 56. ,67

ATOM 1049 N HIS 1016 100. ,399 10. .408 139. ,406 1. ,00 56. ,36

ATOM 1050 CA HIS 1016 100. ,844 10. ,175 140. ,811 1. ,00 57. ,59

ATOM 1051 N PHE 1017 101. ,561 11. ,859 142. ,448 1. ,00 57. ,43

ATOM 1052 CA PHE 1017 102, ,428 12, ,900 143. .019 1. ,00 57. ,26

ATOM 1053 CB PHE 1017 101. ,756 13. ,525 144. .262 1. ,00 59. ,29

ATOM 1054 CG PHE 1017 101. ,888 12. .691 145. ,536 1. ,00 61. ,69

ATOM 1055 CDl PHE 1017 103. ,100 12. ,628 146. ,234 1. .00 62. ,85

ATOM 1056 CD2 PHE 1017 100. ,804 11. ,962 146. ,029 1. .00 61. ,97

ATOM 1057 CEl PHE 1017 103. ,226 11. ,848 147. ,402 1. .00 63. ,09

ATOM 1058 CE2 PHE 1017 100. ,922 11. .184 147. ,193 1. ,00 62. ,16

ATOM 1059 CZ PHE 1017 102. .134 11. .128 147. ,877 1. .00 62. ,36

ATOM 1060 C PHE 1017 103. ,817 12. ,377 143. ,418 1. .00 56. ,18

ATOM 1061 O PHE 1017 104. ,793 13. ,137 143. 454 1. ,00 56. ,25

ATOM 1062 N LYS 1018 103. ,893 11. ,084 143. 738 1. .00 54. 65

ATOM 1063 CA LYS 1018 105. ,148 10. ,462 144. 160 1. ,00 52. 68

ATOM 1064 CB LYS 1018 104. ,867 9. ,246 145. 051 1. ,00 51. ,33 Table 6

ATOM 1065 C LYS 1018 106. .050 10.046 142.998 1.00 51.79

ATOM 1066 O LYS 1018 107, .274 10.033 143.143 1.00 52.60

ATOM 1067 N ASP 1019 105. .452 9.703 141.856 1.00 50.23

ATOM 1068 CA ASP 1019 106, .215 9.298 140.669 1.00 48.35

ATOM 1069 CB ASP 1019 105, .298 8.704 139.591 1.00 48.73

ATOM 1070 CG ASP 1019 104, .915 7.266 139.862 1.00 49.14

ATOM 1071 ODl ASP 1019 105, ,830 6.437 140.063 1.00 49.01

ATOM 1072 OD2 ASP 1019 103, .698 6.968 139.856 1.00 49.31

ATOM 1073 C ASP 1019 106, .930 10.486 140.040 1.00 46.68

ATOM 1074 O ASP 1019 106, .536 11.632 140.237 1.00 47.50

ATOM 1075 N PRO 1020 107, .992 10.227 139.266 1.00 44.76

ATOM 1076 CD PRO 1020 108, .718 8.957 139.111 1.00 45.04

ATOM 1077 CA PRO 1020 108, .724 11.314 138.618 1.00 43.38

ATOM 1078 CB PRO 1020 109. .937 10.609 138.016 1.00 43.53

ATOM 1079 CG PRO 1020 110, .133 9.436 138.912 1.00 44.61

ATOM 1080 C PRO 1020 107, .838 11.904 137.532 1.00 41.94

ATOM 1081 O PRO 1020 106, .804 11.332 137.188 1.00 42.82

ATOM 1082 N LYS 1021 108, ,251 13.040 136.990 1.00 39.67

ATOM 1083 CA LYS 1021 107, .504 13.687 135.931 1.00 37.28

ATOM 1084 CB LYS 1021 106, .621 14.775 136.527 1.00 37.64

ATOM 1085 CG LYS 1021 105, .772 14.264 137.667 1.00 38.77

ATOM 1086 CD LYS 1021 104, .743 15.284 138.098 1.00 39.71

ATOM 1087 CE LYS 1021 103, .909 14.744 139.244 1.00 40.35

ATOM 1088 NZ LYS 1021 102. .948 15.773 139.724 1.00 42.34

ATOM 1089 C LYS 1021 108, .473 14.287 134.927 1.00 35.45

ATOM 1090 O LYS 1021 109. .651 14.454 135.221 1.00 34.78

ATOM 1091 N ARG 1022 107, .986 14.569 133.728 1.00 34.49

ATOM 1092 CA ARG 1022 108, .807 15.208 132.703 1.00 33.99

ATOM 1093 CB ARG 1022 108, .688 14.506 131.346 1.00 35.90

ATOM 1094 CG ARG 1022 108, .969 13.004 131.299 1.00 38.98

ATOM 1095 CD ARG 1022 108, .848 12.540 129.843 1.00 41.25

ATOM 1096 NE ARG 1022 108, .420 11.152 129.670 1.00 42.83

ATOM 1097 CZ ARG 1022 109, .222 10.093 129.748 1.00 44.82

ATOM 1098 NHl ARG 1022 110, .518 10.248 130.005 1.00 46.32

ATOM 1099 NH2 ARG 1022 108, .731 8.875 129.547 1.00 44.61

ATOM 1100 C ARG 1022 108, .168 16.588 132.589 1.00 32.26

ATOM 1101 O ARG 1022 106, .947 16.714 132.720 1.00 32.02

ATOM 1102 N LEU 1023 108, .960 17.629 132.361 1.00 29.70

ATOM 1103 CA LEU 1023 108, .364 18.952 132.240 1.00 27.31

ATOM 1104 CB LEU 1023 109, .045 19.915 133.216 1.00 27.24

ATOM 1105 CG LEU 1023 108, .723 19.725 134.711 1.00 26.31

ATOM 1106 CDl LEU 1023 109, .524 20.709 135.531 1.00 25.75

ATOM 1107 CD2 LEU 1023 107, .240 19.937 134.980 1.00 23.99

ATOM 1108 C LEU 1023 108, .418 19.486 130.810 1.00 25.84

ATOM 1109 O LEU 1023 109, .410 20.081 130.399 1.00 26.23

ATOM 1110 N TYR 1024 107, .339 19.264 130.064 1.00 23.83

ATOM 1111 CA TYR 1024 107 .228 19.690 128.671 1.00 22.57

ATOM 1112 CB TYR 1024 106, .120 18.899 127.983 1.00 20.06

ATOM 1113 CG TYR 1024 105 .878 19.250 126.529 1.00 19.18

ATOM 1114 CDl TYR 1024 105, .143 20.378 126.169 1.00 18.27

ATOM 1115 CEl TYR 1024 104, .860 20.657 124.833 1.00 18.14

ATOM 1116 CD2 TYR 1024 106 .335 18.414 125.509 1.00 18.75

ATOM 1117 CE2 TYR 1024 106. .062 18.684 124.172 1.00 18.37

ATOM 1118 CZ TYR 1024 105 .324 19.802 123.836 1.00 19.29

ATOM 1119 OH TYR 1024 105, .039 20.050 122.506 1.00 19.56

ATOM 1120 C TYR 1024 106 .929 21.173 128.558 1.00 23.20 ro to o o σi m cM vo vo vo r- cn cM in in o oo o CΛ in o o <Λ _> oo r- vD θ θ^ r- σ> oo vo H o σι ro cM in oo tn «3' rO CΛ rH rO H OO T VO O VO rO ^I' m cΛ VD js r— cn vD oθ rH τ o r- o «- co τ r- co I— oo •_ r- ro ^ T H oo co vo o r- H co in m cM vo H o oo H in m o O H rH CΛ OO O O O O r- VD O ^i H in

© © .a cM Cθ τ τ oo τ tn τ m c H θ θ θ ιn τ vo t— cΛ H CM CM r- vo vo ιn ιn τ j co τ ιn τ τ r- oo oo oo oo t— oo τ τ ro ro co τ τ τ ιn ro τ τ τ τ τ

CΛ k CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rO rO rO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

O OOO OO OOOOO OOO OO OO OO O O OO O OOOOOOOO O OO OOO O O OO OO O OO OO O OO O OO υ O OOO O O OOO OO OO O OO O OO O OO OO OOO OO O OOO O O O OOO O O O O O OO O O O O OOO OO O

PM o ^ ^ o H ιn ^ ιn w H m » H ^ ιη H ^ ol H ω N a m ^o <^ m n Φ < ^ Λ o ^ co n H ω ^ H co <Λ o v Φ ^ ιn « lrl r1 N H H t! co c^ι co π „ ^ ^ N ^ ^ M ω ^n ^ ιo ^ ^ fl (D ^ ω ffl ^ ^ o H O H N ι ι ^ ^• n (^( H ιη ^ ιr) ^ ^o co ^ ^ oo O ιn oo « ω n Φ ιn oo » v » ^ι co o a^ cΛ in o in ∞ vo H CΛ 'T cD i ro co co in in vo r- H ^ H ro o co t- o vo in cM co oo -T VO CΛ ro vo OT CM n cD c^ oo r- r— r- vo in vo in vo ^ in 'T ^ 'T CO T CO C CM r r r cM H H O C ro co ro T 'T '-' r cM CM rH H O vo vo vo r- t— r- r- vo i— m vD oo oo cΛ O

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ CM CM CM CM CM CM CM CM CM CM CM CM ΓO rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH

•sp cn CO 00 H in r- CΛ CM rH in CM CO •s- Vo oo o cM CM H ro ro vo r- co vo T in in T oo ro T o ro o r- τ ιn co τ vo cΛ τ rθ rH cM en vo H CM T ro H ro r- r- o in r- rH ro o ro σi r- oo Mr- voo npo ccMM HrH nro oo ωoo ocΛi oo Oo N . H H oO eCΛn rroO CCMM CCΛΛ rr-- i- HH •'»q' oO t.- oo cn o ai co vo cn o in r- CΛ CΛ t- H 00 vo en ro o oo r- ro m cΛ cΛ - cM in cΛ ιn τ cM cΛ o o r~- CM cn cΛ ro VO CM CD rO '- CΛ Cn rO CM Oo m rH CΛ τ H r r- C in τ r- H o ro ro CΛ T

H H ro τ ιn co r τ τ ιn vo t- r- r- ιn ιn vo vo oo crι oo o ιn ιn ιn τ cM CM CM rH θ CΛ H θ H CM rθ rH ro cM cM θ rH cΛ oo r- vo vo m in m m cn σi cΛ O

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rO CM CM CM CM CM CM CM CM CM H CM CM CM CM CM CM CM CM CM CM CM H H H H H H H H rH H H H CM o m τ co vo t— T CM O rO T VO r- r- CO T T CΛ H ιn cM θθ ^r r- r- τ cΛ r- ro cM i-H in oo vo co co co in T m T ro r- o ro t vo σi oo oo vD T T CM CΛ co o cM r- oo r- r- o oo oo m cM r- in m r- in in co in cM oo r— m cΛ r— T T OO T VO ^" OO ^" O H eΛ oo eo co o i-H oo o cM in cM oo o co r- ro T CΛ CM T i oo cn r- o cΛ cΛ ro iΛ o cΛ H o o r— oo T cn r- in oo r- co oo H -i oo ro cM O ro in in o cM i-i r- vo ai H T VO T in T H VO H m ro in vo cM CM m r- r- <Λ oo co r- ιn in

O O O O O O O O O O

^■T in in in in in in VO VO VO VO VO VO VD VD VD t— |-- r- [— r- r- r- r- ∞ CO CO CO CΛ CΛ CΛ CΛ O O O O O O O O O O O H H H H H H H H H H H CM CM CM Cl CM rM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM fO rO i rO rO rO CO r^

O O O OOO O OO O O O O O OO O OO OO O OO OOO OOO OO O O O O O O O OOO O OO OO OOOOOOOOO HHH H HH HHH rHHHrH rHHrH H rHH rHHHHHHHH HH rH HH H rH HHHHH HHH HHHHHHH rHHHHHH rH ι- « w m ι» n M n n M m M m B n w z z z z z z z z >< iH iH < >ι H H >ι W M w w ω w w w w i- ω u w ω u [ιi « w w w w w D x x x x x x x x x x x x x x w ui w w ui w w ui ri ri ri r ri rH- ii rH- x x x x x x x x x x ω a

EH U U U U O U H-t HH iJ j HH Hj ^ HH H iC rtJ ^ rtl rtJ rtl rtl ^ C U C O a O U O CH H C H ^

H CM rH CM ft CQ CD ft cQ CD a ω si tt CQ CD a a CQ CD Q Q ω ω si rtjcoc_D Ha CaM Hω CωMs) tt o z CJ CJ O CJ o z o o o CJ υ z CJ o uuuoz ft ft

CJ o z υ o o z υ υ o Z O CJ CJ CJ CJ O U CJ CJ O υouoυc c cjoozυ

H H CCMM rtO T-T iinn VvDD tr—- OcoO CcΛΛ OO HH CMM ffOO ^^J' iinn VvDD rr-- CoOo CcΛ OO HH CCMM rmO '^q' iinn VvOo rr-- CcOo CcΛΛ O H CM r ' in co r- co cn o H C ro C C CM CM CM r C c ro ro r ro co n r c r ^τ '-₃' '_<ϊ^, ^_jι ^₁ι ^₎i ^_r ^_]i ^ι -_r in in m m in in m in m in vo vo vo co vo vo vo vD vD vD r- r- r- r- r- r- t-

H rH rH H i-I rH rH i-I rH i-H H H rH H H rH H rH H H rH H H H H H H H H H rH H H rH H rH H rH i-H H rH rH rH H H H H H H H H H rH H H i-H H H I rH H rH H H rH rH H i-H H H H H i-H H H H H rH H H H H H H

00

Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ

O o o o o o o o o o o o o OOO O O O O O O O O o o o o o o o o o o o o o o

EH EH H EH EH EH EH EH EH EH EH EH o o o o o o o

EH H EH H H EH EH H EH EH EH fπ EH o o o

H EH EH EH H EH H EH EH EH EH EH

O < ft ft ft ft ft ft < ft ft ft ft tt ft ft ft ft ft ft tt ft ft ft tt ft ft ft ft ft ft ft ft ft ft ft ft ft ft < ft ft ft ft ft < ft < it

rt rt t- ro So r- m r- ^ H r Ln vo ro o H CM ro ro in oo r- r- H ro in o vo H ιn <Λ τ oo r- ro cΛ τ <Λ ιn cΛ ro oo m τ ro oo m ro ιn '- H vo ro ro cΛ oo o cΛ CM r- τ ro ro τ m o ro ro ro oo vo r- H oo cM CM θo m co r- ιn cM ro ιn O H VD in H oo ro cM r- T O c cΛ t— r- vo oθ "Φ CM CΛ ro vD oo (M CM θ -«ι^, o cn oo o ■Si in in in cD T -T in r- cΛ o rO T VD in vD oo r- cD cn cn cΛ co oo H CM rO 'T Co o cM CM co ro ro T '-' T T T in ^i' VO oo o ro T T CΛ o Λ oo oo t— r- oo cM CM CM CM CM CM CM CM CM ro ro ro ro ro ro cM CM CM CM CM CM CM CM ro ro ro ro rθ 'T '3' H. -τ ro oo ro ro co ro ro ro ro ro ro <=- τ T T ro T ro ro ro ro ro ro

H oooooooooooooooooooooooooooooooooooooooooooooooooooooooo u oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

PM H H H H H H H H H cM VO T H T ro co ro σi t— m r- t— ro ro vo *3< CM CM ro (Λ θ oo rH rH r- cΛ m r- CM oo σi t— CM CM VD CM in oo co co r- r- cΛ τ ιn cΛ H. r H ro cM θo vo oo H o oo cM in o oo oo ro <Λ CM in cM "3^, m vD o r- o τ o r- r- oo τ o cΛ oo τ τ cM H I— ro cΛ eΛ O H ro T co co ro H oo cM t— r- τ cΛ eΛ vo ^ι^, r- o o m H H VD m cM VD cn m o τ H ro o τ ro cM θ H θ ιn «-_ r- r- r- CΛ CM cn rH r- H OO VD OO CM CM rO rO in H rH CΛ rH O CM O CΛ CM OO r- O CO rO CM VD O CΛ cM ro ci τ H H θ H θ o cn oo r- vD vD c>j cM co τ ιn vo ιn ιn ro co ro cM CM θ o σ^ cx> cD τ ιn ^ ro ιn ιn τ ιn r- ιn ιn τ cM ro H in v^ ro ro ro ro ro ro ro ro ro ro cM CM CM CM CM ro ro ro ro ro ro ro ro ro n ro ro c co ro r- erι cM m oo o oo oo τ oo r- cn τ r- cM in c cM in r- cΛ _ H vo cM ι-H H vo ro c < in vD oo ro rθ "!>' VD in vD θ rH in o oo r oo cM in r 3ⁱ r o in r- vo vo oo cM H o ro rH oo ro in co co vo cΛ VO H oo i' CM CM H in oo ^ cD H VD _) VD C ro r- oo ro vo vD H in rH CΛ ro cM VD H ro ro oo ro ro r- t- o

O '- T O rO CO VO vO σi O m r- VD qi r- O rH H T H VO CΛ ^ T C Cn rH Cn H CO rH VO σi r- T in T H t— CM H H n oO H C O ^' CM rH r VD in 'T M H

H rH CM CM Cn cO CΛ OO VD r- r- vo co cn o co oo oo co oo o r- cot- r- r- oo cn r- r- co vo r- in ^i' m ro rovo vo vo r- co oo oo cn o cn O H CM H CM CM CM CM CM H H H H H H CM H CM CM CM CM CM r- o cM vo r- o ro o ro m r- oo r- r- vo r- co τ r- cM CM CM r- r- ro r— oo cn o c H VD r- t- cM r- ro H co vo o vo T H ro cΛ f cn H ro H O CM cn cn oo i cM CM H in cM CM H oo ιn cn ro m cΛ in vo H CM o r- o r- Λ H CΛ CM rO O OO CM H H in vo t— p- in . o _ ro oo vo ro cM o m r— O OO ΓO CM O O T ΓO O H T i

VD VO VD OO CM OO in T O H OO H T in r- VO rH O O VO VO C ^r H o ro m T O VD cn T CM H O oo co m o

CM cO T CM T ro in vo r- ∞ co cn cΛ cn o ^ (I) ) m ω m ^ ^ o o H c^ι ιη ιn ( c! N rι ιn t ι^,) ι v ιn fl ιn Φ Φ ι-- ^ Φ ^ Φ ιn M^ι ^f o^ 1J r

H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM

cM CM CM CM CM CM c co ro co c ro c r co ro rO 'T ^ T T T 'T -T ^ in i in in i in in i in in vo o vD vo vo vo vD ^ ro ro ro ro c co ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro m ro ro ro co ro ro ro c ro r^

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O

D D D D D o o o c CD O C O ϋ D U O ω ω ω ω ui H ω i-i w co w o Λ co c co ω o o o o o o o - Q Cu c w ω ω ω ω ω ι_. c- βj C_ oή (£ _- o- QS c_ oS H3 HH H^ H HH HH HH HH HH <; rt; rt; 3 rt; rt; rt; rt: H iH H H H H K 3^H ac κ _- κ a κ w aa c_ CH

H CM co a a ft CQ CD CD Q et; co CD a Q ω ω Q tt OQ CD ft CQ O ft. ft, o o o CJ o o z O CJ CJ O Z O Z Z O O Z O U O CJ O O O U CJ O CJ Z CJ Z O O Z CJ υ O CJ CJ o z o u CJ o O O O Z CJ CJ o z J r- ∞ cΛ θ H C r τ ιn vD r- _- ^CΛ θ H ^CM ro τ ι -> r- ∞ c o H C cθ 'τ ιn _> r— ∞ en o H CM ro τ m vo r- co <Λ θ rH CM ro τ m -> r— co cΛ θ H CM

^ ^ ^ l» 0a ⁽S 00 l⁾3 ⁽ O a! a! fl001 Cl lJl ⁽Λ ⁽!l ⁽Λ ⁽^ ⁽^ ⁽n W O O O O O O O O O O ri ri rt ri H H H H H H N (! ( (^I N ^I N N N n ^ (^,) H H H H H ri H H H H H H H H ri H rt ri H H r( r( H N N N (V| (\| OJ N N N N N M (V! N N N N M N M (V! ( (V| N N N N CN N N tV! (\| rM

X o∑∑∑ΣΣΣ∑∑∑∑∑∑∑∑∑ o EHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoHoEHoEH o

Tdble β

ATOM 1233 CB ARG 1039 124 .432 21, .739 131, .591 1.00 40. .33

ATOM 1234 CG ARG 1039 125 .856 22, .173 131, .337 1.00 42. .49

ATOM 1235 CD ARG 1039 126 .235 21 .758 129, .924 1.00 45. .35

ATOM 1236 NE ARG 1039 126 .170 20, .303 129. .755 1.00 48. ,54

ATOM 1237 CZ ARG 1039 125 .744 19, .683 128, .653 1.00 49, ,62

ATOM 1238 NHl ARG 1039 125 .735 18, .354 128, .605 1.00 49, ,36

ATOM 1239 NH2 ARG 1039 125 .311 20, .383 127, .606 1.00 48. .98

ATOM 1240 C ARG 1039 122 .346 21, .882 132, .887 1.00 37, .46

ATOM 1241 O ARG 1039 121 .852 20, .793 133, .187 1.00 37. .66

ATOM 1242 N VAL 1040 121 .620 22 .917 132, .487 1.00 36. .66

ATOM 1243 CA VAL 1040 120 .168 22, .832 132, .359 1.00 35, .75

ATOM 1244 CB VAL 1040 119 .461 23, .634 133. .479 1.00 35, ,63

ATOM 1245 CGI VAL 1040 117, .970 23, .515 133. .343 1.00 35. ,65

ATOM 1246 CG2 VAL 1040 119 .904 23, .138 134, .832 1.00 35. ,67

ATOM 1247 C VAL 1040 119. .737 23, .392 130. .994 1.00 35. ,53

ATOM 1248 O VAL 1040 120, .135 24, .496 130, .596 1.00 36. ,39

ATOM 1249 N ASP 1041 118, .929 22, .626 130, .274 1.00 33. ,97

ATOM 1250 CA ASP 1041 118 .447 23, .046 128. .967 1.00 32. .42

ATOM 1251 CB ASP 1041 119 .534 22, .848 127. .916 1.00 32, ,62

ATOM 1252 CG ASP 1041 120 .015 21, .411 127, .843 1.00 32, .94

ATOM 1253 ODl ASP 1041 120. .810 21. .104 126. ,933 1.00 33. ,43

ATOM 1254 OD2 ASP 1041 119. .605 20. .591 128. ,695 1.00 32. ,32

ATOM 1255 C ASP 1041 117, .255 22. .175 128, .632 1.00 31. ,66

ATOM 1256 O ASP 1041 116, .714 21, .500 129. .510 1.00 32. ,29

ATOM 1257 N GLY 1042 116, .853 22. .177 127. ,367 1.00 30. ,54

ATOM 1258 CA GLY 1042 115, .727 21. .364 126. .962 1.00 29. ,69

ATOM 1259 C GLY 1042 116, .060 20, .372 125. .866 1.00 29. ,53

ATOM 1260 O GLY 1042 117, .030 20, .527 125. .146 1.00 29. ,47

ATOM 1261 N VAL 1043 115, .248 19. .334 125, ,756 1.00 30. .48

ATOM 1262 CA VAL 1043 115, .418 18. ,319 124. ,732 1.00 31. .18

ATOM 1263 CB VAL 1043 116, .175 17. ,097 125. ,222 1.00 30. ,95

ATOM 1264 CGI VAL 1043 117, .582 17. .153 124. ,723 1.00 31. ,45

ATOM 1265 CG2 VAL 1043 116, .136 17. ,031 126. ,740 1.00 31. ,50

ATOM 1266 C VAL 1043 114, .048 17. .855 124. .350 1,00 33. ,51

ATOM 1267 O VAL 1043 113, .209 17. .590 125. .212 1.00 35. ,18

ATOM 1268 N ARG 1044 113, .814 17. .763 123. ,054 1.00 34. ,82

ATOM 1269 CA ARG 1044 112, .530 17, .319 122. .564 1.00 36, ,01

ATOM 1270 CB ARG 1044 112. .392 17. ,677 121. ,088 1.00 35. ,77

ATOM 1271 CG ARG 1044 112. ,204 19. ,145 120. ,799 1.00 36. ,67

ATOM 1272 CD ARG 1044 111. .240 19. .275 119. ,629 1.00 36. ,95

ATOM 1273 NE ARG 1044 111. .264 20. .585 118. ,999 1.00 36. ,46

ATOM 1274 CZ ARG 1044 112, .322 21. .071 118. ,376 1.00 37. ,37

ATOM 1275 NHl ARG 1044 113. .429 20. .344 118. ,317 1.00 38. ,72

ATOM 1276 NH2 ARG 1044 112. .269 22. ,265 117. ,804 1.00 38. ,11

ATOM 1277 C ARG 1044 112, .379 15. .806 122. .730 1.00 36. ,56

ATOM 1278 O ARG 1044 111. .267 15. .293 122. .861 1.00 37. .22

ATOM 1279 N GLU 1045 113. ,501 15. ,098 122. ,725 1.00 37. ,07

ATOM 1280 CA GLU 1045 113. .479 13. ,648 122. ,830 1.00 39. .00

ATOM 1281 CB GLU 1045 114. .880 13. ,103 122. ,589 1.00 41. ,67

ATOM 1282 CG GLU 1045 114. .959 11. ,601 122. ,703 1.00 45. ,67

ATOM 1283 CD GLU 1045 113. .987 10. ,909 121. ,774 1.00 47. ,99

ATOM 1284 OEl GLU 1045 114. .065 11. ,168 120. ,552 1.00 48. ,20

ATOM 1285 OE2 GLU 1045 113. .152 10. ,112 122. ,266 1.00 49. ,71

ATOM 1286 C GLU 1045 112. ,934 13. ,125 124. ,157 1.00 39. ,22

ATOM 1287 0 GLU 1045 113. ,573 13. 254 125. ,204 1.00 39. ,70

ATOM 1288 N LYS 1046 111. ,755 12. 511 124. ,098 1.00 39. ,02 t- ro ^■)o cn ro co CM CM cn r- co τ H r- co ro rθ H in H VD ιn cΛ VD m o c— T o cΛ vo o vD rH O-i ro cM O i-i ro r- H ro cn ιn ιn τ H CN θ in cΛ cΛ cΛ ro r- fS "«) CΛ H rH cn CM m CM t— in cΛ vo ro vo ro in ro cΛ CΛ co vD T T in iΛ r- ^• ∞ H rO T Co σi Λ oo ro r in ro τ H in τ t- o oo cM co ιn θ H τ r-

© id

© co o H oo co r- r- r- co r- r- r- r- oo cΛ rH eΛ vo r- vD t— co r- oo r- vo vo vD oo H CM CM CM in m ro cM CM ro ro m H o o cn cn o cM ro cM O o

CΛ " £a ro T τ ro ro ro c ro ro ro ro cr) ro ro ro τ n ro ro oo ro ro ro ro ro ro ro ro rθ "- '- ^,τ T co ro ro co ro ro ro n co ro co cM CM ro ro ro ro ro ro

-^ OOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOO

H oooooooooooo oooooooooooo OOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOO

U

PM H r-t H H rH τ ro cM r— *- r- r- r- "!r in ro T m r- H ro τ ro r- rH vo ro ιn <Λ ro rΛ m c- VO H CD O CM 00 σi m σi vD r- co vo σ^ T in o r- cΛ cn vo ro oo m oo vo r- oo o r- tΛ CM r- T CM CΛ T in o CM CD CΛ CM rO O H T in H in O O VD CΛ C .M. o t— r- ι- T co H tθ m CM rH OO τ r- T CM O O <Λ Oθ rθ CM <Λ '- H in θ

CM CΛ O in r— CO CΛ H H r- CO r- T CΛ CO O O VD CO CO T CM OO H CM O ro in <Λ <Λ r- vo in ro o o m vo vo ro cM CΛ σ> oo o τ m oo cM H r- oo c_ι m ιn τ vD ιn vD vo ιn r- ιn ιn τ oo vo vo vD i- r^ t~ vo rxι co cn co co o o cn H CM θ H H H θ CM CM M CM CM H H θ CΛ cn c» cM f^

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rO rO CM rO rO rO rO rO rO rO rO rO rO rO rO r^ H H H H H H H H H H H H H H H H H rH i-H H H rH H H H H rH H H H H H H H H H H H rH rH rH H H H H H H H H H rH H H H H H o ro m τ oo m cΛ cM r- cΛ r- rM CM oθ rH VD o in in H O t- o r- in cM i-H ro r- ro r- ^i vD T O VD VO Oθ rθ (Λ VO H <Λ VO O OO T CM in τ oo in r- vo ro vD VD r- m vo in cM tO rH ro o cM o c cMM HH cCΛΛ H ro H O CM CM T CΛ CM r- cΛ in m co ro vo cn ro H in r- vo vo in H vo ro ro m vo co '- CM in o cn τ cM VD ιn ιn oo m <M rH H r- vo oo cn τ (Λ τ vo m oo cΛ τ ιn <Λ CM CM cn ιn cM CM θ CM <Λ in oo θ H ro r- ιn ιn rH H H H r- o ιn θ ι-ι co r- τ r cM

H H H O O CΛ O O O CTl CO CO Cn cO O H cM ro ro ro o o o o cΛ cn o o o ro cM CM H CM T in ro -v T in ro ro T T ro cM rH O oo r- r- ro ro rH H in cM O CM in r- in m co r- o vo in vD cM T rH vo vD oo '-. o oo r- H in O CM CM o r- CM 00 I— H CM CM H T Vo co cn o vo cO rH co cn oo CΛ oo in cΛ H VD ιn τ r- cn o cn oo rθ H vo cn τ vo m vD o r- o T r- T H m cn cn co T t— co o m r- in cM co in rH r- rH CΛ r- r- H o r— t— CM ^r cM CΛ <Λ H r— oo in ro vD ^r H O T ro r— Λ H H in co ro H CM en oo r— vo in H H CM ro ro τ τ m m vD vo r- oo r- vD in r- co r- cn cn r- r- r- t- cΛ θ H θ H CM vo vD m τ ro τ ro cM ro cM co cM co cM CM H o ro τ o o o o o H rH rH i-H H H H CM CM CM CM CM H H H rH

H H r-t H H rH H H rH H H H

IC φ φ φ lO φ l₀ lO ^ |^N |v l ^ ⁽ _{O IO} ⁽ ₀ ^|)) ^|i) ^j ₁ eθ O) II1 01 0> (Λ Cn θl lJ1 0 0 0 0 0 0 0 0 0 0 H ri H ri H ri ri H N ( N N N N N C N

T -t -T -ςr 'T T T T T 'T T T T .T 'T _'T T -T T T 'T ^ T 'T T T 'T T T i in in-i ui inin ini^ o o o o o o o oo o ooo o o o oooooooo oo o oo o o ooooo oo oooooooo ooooo ooooo

H H rH H H H H H H H H H H H H H H iH H H rH rH H rH rH H H H H H rH H H H H H H H H H rH H H i-H rH rH H H H rH H H H H rH H Λ O CO CO CO O CO c ρi c_ Dc; cc; cH _ fc _ c_ Dj H α^ _ αι θ θ θ O O O θ c c co c co o co c c co w ω w X X X X X H X < ω ω ω ω w ω co c co co o o θH CH CH C_ o_ o» o_ M H H HH H rH H rH H HH H^ H-l H-l μi H-l ,-1 μi HI j ω c o c rt; < rt; rt; rt; rt; c c_ -ι c_ θj ij C a3 a. E B_ _: _ _: ικ _ a ft CQ CD CD Q υ o Z CJ U CJ CJ O CJ O z υ o υ υ o z υ o

⁽Jι O H ⁽^ι ⁽n ^ ιn » ^ m ιIl O ri W ⁽^ ^ ιn ω ^ flo <>l O H ⁽ ιη ι^| ιn a ^ co ol O H (^ι n ll^| ιrl ^ (D m o H (^ι ιn 9 l ω ^ <D !ll O H N ι^,1 ^■J

Oi m m O> IJI ⁽J10\ m m m 010000000000 H W H H H H H H H H N N N N I! N N [! N N ( m f^ll ( f I») (1 t rn n ^ ^ <f <l^l *»

CM CM CM CM CM CM CM CM CM CM CM ro ro ro ro ro ro ro ro ro c c ro ro ro ro n m ro n m ro n r^

1-I H H H i-l rH H H rH H H H H H rH H H H H H H H H H H H rH H H H H H H H H H i-l rH H H H H H rH H H H H H H rH rH rH H rH H so

ΣooΣΣooΣΣoΣoΣooΣΣoΣΣΣΣΣoΣΣΣΣ∑ΣΣΣΣΣΣΣΣΣΣΣΣΣΣ ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ

EH EH EH EH EH EH EH EH HoEHoEHoEHoEH EHoEHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEH OOOOOOOOOOOOOOOOOOOOOOO

EH EH EH EH EH EH EH EH EH EH EH EH H EH EH EH EH EH EH EH EH EH EH o ft ft ft < < ft ft ft ft ft < < tt < < ft < ft ft ft ft tt ft ft ft ft ft ft ft ft rt; rt; fiC fiC rt; rt; rt; rt; rt; rt; rt; rt; rt; rt; rt; rt; ri; rt; rt; rt; it

-

Table 6

ATOM 1345 N LEU 1053 112 .225 14.219 136, .198 1.00 29.79

ATOM 1346 CA LEU 1053 112 .352 15.100 137, .349 1.00 29.36

ATOM 1347 CB LEU 1053 111 .990 16.532 136. .939 1.00 29.08

ATOM 1348 CG LEU 1053 112, .364 16.937 135, .507 1.00 28.41

ATOM 1349 CDl LEU 1053 111, .923 18.366 135, .238 1.00 28.73

ATOM 1350 CD2 LEU 1053 113 .852 16.785 135, .299 1.00 27.13

ATOM 1351 C LEU 1053 111 .474 14.680 138, .518 1.00 29.19

ATOM 1352 O LEU 1053 110. .356 14.209 138, .337 1.00 30.04

ATOM 1353 N GLN 1054 Ill, .988 14.865 139, .725 1.00 28.59

ATOM 1354 CA GLN 1054 111, .252 14.522 140, .927 1.00 27.99

ATOM 1355 CB GLN 1054 112, .114 13.674 141, .848 1.00 30.24

ATOM 1356 CG GLN 1054 111, .328 12.989 142, .939 1.00 33.29

ATOM 1357 CD GLN 1054 110, .286 12.031 142, .386 1.00 35.36

ATOM 1358 OEl GLN 1054 110, .615 11.090 141. .656 1.00 35.98

ATOM 1359 NE2 GLN 1054 109, .020 12.263 142, ,733 1.00 37.07

ATOM 1360 C GLN 1054 110, .877 15.823 141, .615 1.00 27.38

ATOM 1361 O GLN 1054 111, .707 16.470 142. .255 1.00 26.70

ATOM 1362 N LEU 1055 109, .624 16.224 141, .455 1.00 27.43

ATOM 1363 CA LEU 1055 109, .174 17.464 142, .062 1.00 27.22

ATOM 1364 CB LEU 1055 108, .036 18.086 141, .253 1.00 26.41

ATOM 1365 CG LEU 1055 108, .096 18.061 139, .724 1.00 25.53

ATOM 1366 CDl LEU 1055 107, .477 19.348 139. .210 1.00 26.11

ATOM 1367 CD2 LEU 1055 109, .516 17.932 139. .224 1.00 25.01

ATOM 1368 C LEU 1055 108, .717 17.155 143. .477 1.00 27.58

ATOM 1369 O LEU 1055 107, .894 16.266 143. .705 1.00 28.23

ATOM 1370 N GLN 1056 109, .282 17.883 144. .430 1.00 27.30

ATOM 1371 CA GLN 1056 108, .973 17.686 145, .834 1.00 26.90

ATOM 1372 CB GLN 1056 110, .237 17.290 146. .587 1.00 25.90

ATOM 1373 CG GLN 1056 110. .053 17.177 148, .068 1.00 25.61

ATOM 1374 CD GLN 1056 109. .254 15.962 148, .458 1.00 25.90

ATOM 1375 OEl GLN 1056 109. .647 14.830 148, .180 1.00 26.01

ATOM 1376 NE2 GLN 1056 108. .125 16.188 149, .109 1.00 26.29

ATOM 1377 C GLN 1056 108. .470 18.997 146, .373 1.00 27.81

ATOM 1378 O GLN 1056 108, .977 20.057 146, .004 1.00 28.43

ATOM 1379 N ALA 1057 107, .470 18.942 147, .239 1.00 28.38

ATOM 1380 CA ALA 1057 106. .955 20.170 147. .813 1.00 29.08

ATOM 1381 CB ALA 1057 105. .489 20.034 148, .133 1.00 28.76

ATOM 1382 C ALA 1057 107. .733 20.419 149. .080 1.00 29.91

ATOM 1383 O ALA 1057 108, .043 19.482 149, .818 1.00 28.98

ATOM 1384 N GLU 1058 108. .083 21.674 149, .326 1.00 31.39

ATOM 1385 CA GLU 1058 108. ,793 21.986 150. ,553 1.00 32.34

ATOM 1386 CB GLU 1058 109. ,930 22.975 150, ,309 1.00 32.18

ATOM 1387 CG GLU 1058 110. ,960 22.983 151. .429 1.00 31.46

ATOM 1388 CD GLU 1058 111. ,597 21.618 151. .657 1.00 32.73

ATOM 1389 OEl GLU 1058 111. .898 20.928 150, .655 1.00 33.37

ATOM 1390 OE2 GLU 1058 111. ,810 21.239 152, .833 1.00 31.34

ATOM 1391 C GLU 1058 107. ,741 22.574 151, .478 1.00 32.21

ATOM 1392 O GLU 1058 107. ,961 22.715 152. .672 1.00 33.06

ATOM 1393 N GLU 1059 106. .586 22.889 150, .896 1.00 32.19

ATOM 1394 CA GLU 1059 105, ,437 23.419 151, .617 1.00 32.10

ATOM 1395 CB GLU 1059 105. ,829 24.600 152, ,491 1.00 35.18

ATOM 1396 CG GLU 1059 106. ,378 25.769 151, .712 1.00 40.63

ATOM 1397 CD GLU 1059 106. ,664 26.957 152. .598 1.00 43.35

ATOM 1398 OEl GLU 1059 107. ,449 26.789 153, .562 1.00 44.97

ATOM 1399 OE2 GLU 1059 106. ,106 28.048 152. .331 1.00 45.15

ATOM 1400 C GLU 1059 104. ,420 23.858 150, .589 1.00 30.54 o t- ro __ rH in O CM VO H T rO m _> cM vo JS t— ιn rθ H <n ιnoo τ vθ r- ro r- o cn cn o in o ^•_' co Φ Φ _ ro CM CM co ro T T

H oooooooooooooooooooooooooooooooooooooooooooooooooooooooo υ oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

PM

^■rji r- r— vo oo CΛ r— VD T Vo cΛ H CM r- VD t— ro r- 'a' H CM ro oo o H CM O t— in H '-p ro t— t— oo c— rH ι-r cM Vθ τ co τ co o co r- ro cn oo t— t— oo τ r- o H CM rH VO o oo oo Cϊ vo r o [~ r- o r- r o H θ ^ oo c <Λ M in vD τ cn ιn o ov! co o- CM H co co ^ o c H in vD in ιn co oθ 'τ c H H CM in c cθ H T O cD _ln o o H N cv! O N ^ U N N O _ o - ιn n ιn ι o ιn ^ m ^ o a ιo ^ ^ N * cl o ^ o m H (Il n n ιn ^ H ^l ln H ω ι») (! _ cn H O O rH CM H H CM O cn σ^ r- vo vo m r- co oo r- oo vo i— ιn m τ τ cM τ τ ιn τ ιn ιn ro ro cM ι-ι o oo o co H CM CM ^r T in o cn cn oo oo ιn ιn ιn ι m ιn ι m m τ τ τ τ '- ^,5i^, '3 «j' τ ι^, τ τ ^i' T '3^, τ τ ι-r i3^, "-»ι ι-r τ τ τ ro ro r ro

H T CΛ CΛ O H T T O T O ιn r- cn oo cΛ (Λ ro cM CΛ ro ιn vD ro ιn c m H Hj> ro m τ cn vo σι o cn H cΛ ιn o m τ ιn τ τ oo cM in cM CΛ VD in o vD o OO CΛ H CM CΛ CM CM rH r- T T H CΛ oo r- in r- T H T H CM O ro cn vo o oo ro cM cn r- o cM ^r vO rH τ ιn vD ι-ι r— σi cΛ oo oo o cΛ in oo cΛ o cΛ r— CM Γ- CΛ O in CM CM O OO CM CO Cn T ιn cΛ r- cΛ VD ro ιn cM '3' in cM ro ι-ι oo H CΛ cΛ θ H co r- cn ιn cn cM θ CM rH ro oo oo T O rH ro in co o o cM in vo co oo *- c ni T in T in m vo in vo in o T in in vD i in vD vo r- T r T CM CM H CM r T H H O CΛ O O H O H O H CM Cn O OO r- VD m ιn<*c)iflιflioιn-»

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H CM CM CM CM CM CM CM CM H CM rH H H rH ro cM rθ H CΛ r- τ r- ro o vo ι-ι ιo vo r- CM ro O rH H CM H in vD ro o o ro t- T CM r- m cM rH t- vD o o vo co oo r- r- oo H in o oo ro eΛ CM CM ro vD CΛ σι rθ H co τ m oo t— r io'l c υΛi ic'ol o _o ICNM C _θ nH ιr*-« o υ -^ IMM lC—— ^■r cxj T^ T rt c _ι 'T 'T H r c W T-r' H O oo ro m - T ∞ cΛ ro oo r- c rO H oo o r- ^ r- T Oo ro ro in H co r- H in o m cM vo o oi Φ -1 m CΛ t- O CΛ σi OO CO OO CM O rH rH O CM rO VD VD OO r- T m in r- H τ oo VD vo vo cM ro cM CM τ ιn vD r- oo vo r- r- r- τ m τ ιn ιnvD VD r— r—

< o-5 ccτn> rcΛn rcnΛ rcnn ro-ι o-ι ιo-ι ro-ι <--ι r-ι _ι o o o θ O O O O O O rH

o o o o o o o o o o o H H H H CM CM CM CM CM CM CM ro ro ro ro n ro ro τ 'T 'τ τ *τ ^ ιn ιn ιn ιn ιn ιn ιn ιn vo vo vo vo vo vo vo vo vo r- r- r^

Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ VO Φ Φ VO Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo

Λ c cύ cύ Pi Pύ cύ cύ c & cύ Pi r H rH H iύ rt f f t tt f o «ι; (< (i: < «ι; rt! (i; (ii fil ^ < c) u u o > > > > > > > B n ((i w oi (n H H H H H H H H ₍q ₍j j Hi _hi Hi _hj _hj j (5(j .

Oa u Q U N a a; ft rtj eα D i rti m cD CD rt! CQ CD rtl CQ CD CD O ft m CD Q M J ft O Z U O CJ CJ Z O Z Z o o z υ o o z o cj υ υ cj o z u u c o υ o Z O U O CJ O Z O CJ CJ CJ O CJ O z υ o cj o υ z c o Z CJ u

vo r- 1 Σ Σ Σ Σ Σ Σ Σ Σ ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O OOOOOOOOOOOOOOOOOOOOOO EH EH H EH H H EH H EH EH EH EH H EH H EH EH EH EH EH EH EH H EH H EH o ft tt tt < ft fζ ft ft f t<i f f£ Z t t t rt ft tt t£ tt_l f t £ r% f£ f f f ft tt fζ t% tt f ft fC fti, t f ft ft t t t f ft

ro f^β to oo co ro f in t— vo vo H CM r- m -j ω co cKΛ O H ■T Λ O in ro vD o ro ro r- ro cM VO T vo c cM co r- ro H c i r T H H in '^i' oo c rs _ CΛ H in 00 CM O H CΛ 00 O O σi r- o cM co vD CΛ CM cD θ H τ cM in τ o oo ιn ro t- H '-r' in '- ro ιn ro vo vo r- ιn ro ιn ιn ro oo vD CM VD r- ιn

©

© a in co vo ^ c_M CM Oo r- o rΛi cM in cM H CM ro in ^ ro in vo oo o cΛ CM r- vo oo o ro r- cΛ c in vD VD o o o o CM VO r- CΛ r- OO CΛ O CΛ OO CΛ O H H CM CM

CΛ _CM CM _CM _CM _CM C_M CM CM co co ro ro ro ro ro ro ro ro ro ro ro c -r ro ^ ro ro ro T T 'T T in in in in ^ T _'T 'T T T -sr T T 'ϊ' T m r r rO T -s- ^- T 'a' i^ O O_O O OO O OO OO O O O O O O O O OO O OO O OO OOO OO OOOOOOO OO OOO OOOOO OOO OOO O

H OO_OOOO O OO OOO OO O O O O O O OO OO OOOOOOOO OOOOOOOO O OOO OOOOO OO O O O O O υ

PM H H rH H i-H ^oιnιlo■!^ <Λ 00 I— VO t- ro ro ro co ro

H H m τ cM CM cn cM θ cn oo r— ιn τ ιn cM H VD CM <Λ vo o _ ιn co l— co cM ro H io vo oo in m oo r- o H co vo m cΛ CΛ T in cM rH co ro r- o cM O H ro co T Vo cM ro H r- T ro ro vo in cn H co cM T O cn o T t— - Tm moo oo ro r- in t— oo oo cn o m Λ CM r- co H in m H CO H CM (Λ O t- Oθ r- CΛ H r- H m rH H r ^ i-H H I— T in H in Λ r— Cn cO CM rH O T H l— r- oo oo co r- o cM T CM VD CM t- T o m in H T CΛ VD T CΛ r— σi CO T T i '- VD rO CΛ O O H H O τ r c i H cn H H H H θ θ H H H rθ 'T Ln 'T τ ro ro cM CM CM ro ιn ιn vo t- cD r- oo oo oo cn oo oo r- cn o o cn oo t— σi oo r- vo H CM H co rO T T T

H CM CM H H H H H H H CM CM CM CM CM CM CM CM t

CO CΛ OO CM CM r- OO CM OO r— CΛ O H CΛ CO r- r- CM O T T CO CM m O '-' H eΛ CΛ CM rO cΛ oo r- m in H CM CM vo H cn vo ro o H o ^ r- oo in vD H r- H

CM CM Vo t— r- in ro oo t— ιn oo ro vD 'a< vo τ oo cn o oo o cM cn cM vo vD θ θι r- ro vD CM ι-H *«- r- '3^, H r- vD oo m oo ιn r- ro r- <M r- ιn vD oo cM CM CM VD i H ro in -r oo H cn vo cM in in r- t- r- vo r- '- oo cΛ co cn oo r- r- rΛ ro ro vD CΛ oo cM τ ro cn m vo vo vo τ cM θ θ oo r- ιn ιn ro τ τ ro cM θ oo cΛ τ l iii in in ^ ^ to m oi iii oi o H O H d H N O O H ri O N ri N O O H iη ^ iΛ ω in ^ w m m oj co co iJi m io tf ^ ^ iD iΛ r- r- io in iB ij

H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H H H H H H H H H rH H H rH H rH rH H H rH i-l H H H H H H H H H H H H H H H H H H H H H H rH H H H H H H H H H H H H H H H H H H H H H H H rH rH H H rH H H H H

r- OO CD CD OO CD CO CD Cn cn cn cΛ Cn cn θ O O O O ιH H H H H H H H CM CM CM CM CM rM CM CM CM CM CM rθ rθ rθ n r^ φ φ φ φ φ φ Φ W ^ t~ ^ t-- ^ ^ ^ t t-- ^ ^ r^• ^ ^^• ^ ^ ^ r-^• ^ ι r- ^ ^ r-^• ^ ^ r^■ (^ ^ t^s t^N I ι~ ^ r^ r- ^- r' r^■ ^ r ^-

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O H rH H H rH rH H rH rH rH H H H H H H H H H H H H H H H H rH rH H H rH H H H H H H rH H H H H H H H H H H rH H H rH H H H H

>H ^ Hq j μ) HH ^ ,-1 p5 r; p5 ι_ B; ι_ rf d rf z Z i_ l_ 2 Z 2 Z U - - O O O - U O U ϋ (_ a; - D50- l_

►a rt; rt; rt: rt; rt; rt; ω ω ω ω w ω H-i H3 HH i H3 ω c iΛ c co w , θH C_ θH θ^

0 > > > > > > > w n ω m m n < (< < ι< < < rt; ιa; < ^ rtl < ^ EH EH h h H h h H B h h ^ iH ^ tH Hi Hi Hi r-H CM H CM H CM H CM CQ CD CD rt! CQ CD CQ t Q C rti cQ CD a ω si :-. -, tt B O Q W Q B N l ft CQ CD a Q Z O CJ J O CJ O CJ CJ o υ o Z CJ o CJ z υ f u oD oa zQ cj o z υ o υ υ z υ z z cjo z o CJ CJ CJ O O O CJ O CJ O O O O U CJ 0 H (^l (O fl ιn ^D ^ (om o ri ^ι o o o o o o o o o o H H H in in in i^ H H H H c-H H H H H H H H H

Table 6

ATOM 1513 C LEU 1074 117 .258 24. .334 140, .460 1.00 41, .43

ATOM 1514 O LEU 1074 116 .326 24, .548 141, .243 1.00 41, .50

ATOM 1515 N ALA 1075 118 .289 25, .161 140, .311 1.00 42. .19

ATOM 1516 CA ALA 1075 118 .391 26, .412 141, .058 1.00 42. .44

ATOM 1517 CB ALA 1075 119 .536 26, .329 142, .046 1.00 41, .88

ATOM 1518 C ALA 1075 118 .608 27, .590 140, .106 1.00 43. .17

ATOM 1519 O ALA 1075 119 .308 27, .459 139, .101 1.00 42, .34

ATOM 1520 N MET 1076 117 .993 28, .732 140, .416 1.00 44, .63

ATOM 1521 CA MET 1076 118, .134 29, .932 139, .595 1.00 46. .04

ATOM 1522 CB MET 1076 116. .769 30, .543 139, .269 1.00 47, .68

ATOM 1523 CG MET 1076 116, .832 31, .817 138, .414 1.00 49, .54

ATOM 1524 SD MET 1076 115, .200 32, .466 137, .860 1.00 50, .79

ATOM 1525 CE MET 1076 114, .834 33, .601 139. .156 1.00 48, .61

ATOM 1526 C MET 1076 118, .972 30, .942 140, .354 1.00 47, .36

ATOM 1527 O MET 1076 118. .577 31, .417 141, .422 1.00 47, .71

ATOM 1528 N LYS 1077 120, .138 31, .257 139. .799 1.00 48, .65

ATOM 1529 CA LYS 1077 121, .054 32, .204 140. .411 1.00 50, .09

ATOM 1530 CB LYS 1077 122, .428 32. .063 139. ,774 1.00 49, .88

ATOM 1531 CG LYS 1077 122, .892 30. .620 139, .686 1.00 49, .37

ATOM 1532 CD LYS 1077 122. .854 29, .934 141, .044 1.00 49, .96

ATOM 1533 CE LYS 1077 123, .705 30, .668 142, ,081 1.00 49, .24

ATOM 1534 NZ LYS 1077 123, .839 29, .874 143, ,343 1.00 49. .00

ATOM 1535 C LYS 1077 120, .536 33, .627 140, .256 1.00 51, .61

ATOM 1536 O LYS 1077 119, .554 33, .863 139. .548 1.00 51, .81

ATOM 1537 N GLU 1078 121, .202 34. ,570 140. ,918 1.00 53. .33

ATOM 1538 CA GLU 1078 120, .805 35. .980 140. ,892 1.00 54, .67

ATOM 1539 CB GLU 1078 121. .730 36. .793 141, ,789 1.00 56. .39

ATOM 1540 CG GLU 1078 123. .154 36, .855 141. .286 1.00 60, .41

ATOM 1541 CD GLU 1078 124, .030 37, ,707 142. ,175 1.00 63, .75

ATOM 1542 OEl GLU 1078 123. .617 38, ,851 142, .485 1.00 64. .51

ATOM 1543 OE2 GLU 1078 125. .127 37. .234 142, .559 1.00 65, .35

ATOM 1544 C GLU 1078 120. ,756 36. .641 139. ,512 1.00 54. .55

ATOM 1545 O GLU 1078 119. ,907 37, ,499 139, .270 1.00 54. .10

ATOM 1546 N ASP 1079 121. .663 36. .269 138, ,612 1.00 53, .83

ATOM 1547 CA ASP 1079 121, .658 36, .875 137, .279 1.00 53, .00

ATOM 1548 CB ASP 1079 122. ,962 36. ,564 136, ,539 1.00 52, .34

ATOM 1549 CG ASP 1079 123. ,172 35. ,087 136. .347 1.00 52. .66

ATOM 1550 ODl ASP 1079 124. ,074 34, ,708 135. ,574 1.00 52. .13

ATOM 1551 OD2 ASP 1079 122. .434 34. ,304 136. ,981 1.00 52. ,70

ATOM 1552 C ASP 1079 120. ,472 36. ,359 136. ,460 1.00 52. ,05

ATOM 1553 O ASP 1079 120. ,171 36. ,877 135. ,377 1.00 51. ,50

ATOM 1554 N GLY 1080 119. .807 35. ,331 136. .984 1.00 50. .75

ATOM 1555 CA GLY 1080 118. ,668 34. ,752 136. ,295 1.00 48. ,77

ATOM 1556 C GLY 1080 119. ,015 33. ,559 135. ,426 1.00 47. ,34

ATOM 1557 O GLY 1080 118. ,249 33. ,205 134. ,532 1.00 46. ,65

ATOM 1558 N ARG 1081 120. ,165 32. ,939 135. .679 1.00 46. .16

ATOM 1559 CA ARG 1081 120. ,579 31. ,780 134. ,903 1.00 45. ,71

ATOM 1560 CB ARG 1081 122. ,084 31. ,834 134. ,626 1.00 47. ,53

ATOM 1561 CG ARG 1081 122. ,955 31. .772 135. .864 1.00 49. ,72

ATOM 1562 CD ARG 1081 124. ,439 31. ,920 135. ,531 1.00 50. ,75

ATOM 1563 NE ARG 1081 125. ,286 31. ,647 136. ,692 1.00 52. ,82

ATOM 1564 CZ ARG 1081 125. ,373 32. .422 137. ,772 1.00 53. ,14

ATOM 1565 NHl ARG 1081 124. ,671 33. ,542 137. ,858 1.00 52. ,95

ATOM 1566 NH2 ARG 1081 126. 154 32. .064 138. ,783 1.00 54. ,10

ATOM 1567 C ARG 1081 120. 229 30. ,518 135. ,671 1.00 43. ,90

ATOM 1568 O ARG 1081 120. ,166 30. ,535 136. ,891 1.00 44. ,30 Table 6

ATOM 1569 N LEU 1082 119, .988 29. .430 134, .953 1, .00 42. ,56

ATOM 1570 CA LEU 1082 119. .632 28. .168 135, .586 1, .00 41. .88

ATOM 1571 CB LEU 1082 118. .513 27, .464 134, .804 1, .00 39, ,65

ATOM 1572 CG LEU 1082 117, .245 28, .286 134, .563 1, .00 38, ,35

ATOM 1573 CDl LEU 1082 116, .291 27, .517 133, .699 1, .00 36, .79

ATOM 1574 CD2 LEU 1082 116. .597 28, .642 135. .889 1, .00 38, ,70

ATOM 1575 C LEU 1082 120, .830 27, .246 135. .682 1, .00 41, ,96

ATOM 1576 O LEU 1082 121, .814 27, .411 134. .972 1, .00 41. .58

ATOM 1577 N LEU 1083 120, .725 26, .275 136, .576 1, .00 43, ,51

ATOM 1578 CA LEU 1083 121, .767 25, .277 136. .804 1, .00 45, ,29

ATOM 1579 CB LEU 1083 123. .088 25, .941 137, .202 1, .00 47, ,13

ATOM 1580 CG LEU 1083 123, .080 26, .795 138, .471 1, .00 49, .20

ATOM 1581 CDl LEU 1083 123. .140 25, .887 139, .699 1, .00 50. ,34

ATOM 1582 CD2 LEU 1083 124. .273 27, .751 138, .452 1, .00 49. .30

ATOM 1583 C LEU 1083 121, .282 24, .366 137, .917 1, .00 45. .30

ATOM 1584 O LEU 1083 120. .358 24, .719 138. .655 1, .00 45. ,86

ATOM 1585 N ALA 1084 121. .904 23, .204 138, .057 1, .00 45. ,08

ATOM 1586 CA ALA 1084 121. .466 22, .273 139, .082 1, .00 46, ,14

ATOM 1587 CB ALA 1084 121. ,001 20. .983 138. .434 1. .00 45. ,94

ATOM 1588 C ALA 1084 122, .528 21, .980 140, .128 1, .00 46, ,93

ATOM 1589 O ALA 1084 123, .569 21. .401 139, .822 1, .00 47, .13

ATOM 1590 N SER 1085 122, .246 22, .383 141, .366 1, .00 48. .12

ATOM 1591 CA SER 1085 123, .152 22, .174 142. .489 1, .00 48, ,98

ATOM 1592 CB SER 1085 122, .752 23. .072 143, .655 1, .00 48. .95

ATOM 1593 OG SER 1085 123, .625 22, .857 144, .751 1, .00 52, .03

ATOM 1594 C SER 1085 123, .143 20. ,717 142. .954 1, ,00 49. ,51

ATOM 1595 O SER 1085 122, ,150 20, .008 142, .780 1, ,00 50, ,20

ATOM 1596 N LYS 1086 124, .246 20. .270 143. ,550 1, .00 49, .42

ATOM 1597 CA LYS 1086 124. ,327 18. ,897 144. ,022 1. ,00 49, ,13

ATOM 1598 CB LYS 1086 125. .782 18. .477 144, .221 1, ,00 50. ,70

ATOM 1599 CG LYS 1086 125. ,969 16, .970 144, .344 1, .00 52, .87

ATOM 1600 CD LYS 1086 125, .581 16. .261 143, .049 1. .00 54, .61

ATOM 1601 CE LYS 1086 125. .953 14, .777 143, .073 1. .00 55. ,42

ATOM 1602 NZ LYS 1086 125, ,678 14. • 111 141. .762 1. .00 55, ,89

ATOM 1603 C LYS 1086 123, .573 18. .783 145, .334 1, .00 48, .17

ATOM 1604 O LYS 1086 123. ,048 17. ,721 145, .671 1. ,00 48, ,36

ATOM 1605 N SER 1087 123. .528 19. ,883 146, .076 1, ,00 46. ,90

ATOM 1606 CA SER 1087 122. .822 19. .917 147. .351 1, ,00 46. .76

ATOM 1607 CB SER 1087 123. .809 20. ,024 148. ,523 1. ,00 47. ,35

ATOM 1608 OG SER 1087 124. ,816 20. ,994 148, ,282 1. ,00 49. ,65

ATOM 1609 C SER 1087 121. ,857 21. ,088 147, ,336 1, .00 46. ,01

ATOM 1610 O SER 1087 122. ,063 22. ,067 146. ,636 1. ,00 46. ,35

ATOM 1611 N VAL 1088 120. ,793 20. ,989 148. ,108 1. ,00 46. ,03

ATOM 1612 CA VAL 1088 119. ,792 22. ,038 148. .112 1. ,00 46. ,71

ATOM 1613 CB VAL 1088 118. ,524 21. .563 148. .840 1. ,00 46. ,96

ATOM 1614 CGI VAL 1088 117. ,427 22. ,596 148. ,709 1. ,00 47. ,19

ATOM 1615 CG2 VAL 1088 118. ,069 20. ,241 148. ,253 1. ,00 48. ,07

ATOM 1616 C VAL 1088 120. ,254 23. ,350 148. ,722 1. ,00 47. ,27

ATOM 1617 O VAL 1088 121. ,065 23. ,370 149. ,651 1. ,00 48. ,46

ATOM 1618 N THR 1089 119. ,730 24. .444 148. ,178 1. ,00 47. .34

ATOM 1619 CA THR 1089 120. ,035 25. ,792 148. ,650 1. ,00 48. ,06

ATOM 1620 CB THR 1089 121. ,104 26. ,468 147. ,793 1. ,00 49. ,46

ATOM 1621 OG1 THR 1089 120. 468 27. ,273 146. ,790 1. ,00 50. ,85

ATOM 1622 CG2 THR 1089 121. .990 25. ,417 147. ,122 1. ,00 49. ,79

ATOM 1623 C THR 1089 118. 750 26. ,596 148. ,517 1. .00 47. .80

ATOM 1624 O THR 1089 117. 827 26. ,181 147. ,820 1. .00 47. ,73 rt r- ro vo CM CM -r en co o H cπ r- t- o ro o αj co oo cM ro in rO 'T '-' VD CM σi in vo ^r cM CM o r- H ro vo cn o oo cn rO H in cM r- o oo co o o o cM ro in cM CM O

<s _ o no co oo vo in cΛ H r '- oo cΛ oo ro H ro oo ^i' oo cM r- o in cM CM r 'g' σi r- H D H vo m oo rr c r- o in m co in o o H o r- rH CM co vD in ^j cD co o

© ,a __ c H _'- _> vD _-> _ι oo r- (Λ θ H CM H in ιn r H cη cr^,ι cn cΛ vo _ι _ι vD vo vD io o vD ^

CΛ rx ^ τ ιn _^ ιn ι ^ ^ ^ -τ 'τ tn ιn ι ι ^ ^,τ 'τ τ τ τ ro (^ co (^ ro o ro ro r ro ro c r ro ro r c r r co ^ ε oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H? oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

U

PM H H H H H H H H H H H H H H HH H H ro t— in H H cM H t- vo o in vo in o^ H in cD CΛ in cD n r- vo in cM CM ro oo 'T O Λ r- c O o co ro cM o r- cM O 'T H in o r- o o in ' H r CΛ O CM

W N n H O 'i' iη in n in n oo oi o iΛ in 't H N io ri h ^ iη iη H in iΛ Λ ω H o n o N H Λ n N oo io v N in Φ in Φ cn ^ o H N oo cn in H H o oo (o a ^ Λ ^ ιη ιD co H ιn (O ιn ( N ιn ι)l ^ ^ ιn (^ι ιfl o m oo ι_ ^D ιD ^o ^ H (^ι ^ v ιn ι H ^o ^ ιn H H n ι^,l ln '* c_o in r- rH o

_ϊ eΛ o _ϊ _3 θ r- r- vo ιn τ τ ^,-- '- cθ '-^, ro ιn τ τ τ τ τ ιn ιn r— r— t— oo oo <Λ eΛ τ τ τ ro H H O H O H O T ro ro rO T T in in vo vo cM rH

^•3* ^J* ^ ^3* ^J* ^3* ^P ^3* ^sl* ^3* ^ϊ* ^,**' ^- ^3* ^-* ^3* ^-J* ^-3* ^J* ^3* ^3* H H H H H H H H H H rH H H H H H H H H H H H rl ιn Φ (Jι ιc _ ln Λ m Λ r-^• t— ιn r- τ oc' CO 03 m o H O <ll (^ o ιll fl o H O N ^ w ιΛ ^ ')^, ιn ^ Φ Φ ω ln '» ω ιη ιn ^ ^ m Φ ^ ^ Φ _ Φ ^ ιβ 0) 03 O O <ι o n H (^ι r• _

CM CM CM n rO rO CM CM CM CM CM rO rO rO n r CM Ol CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rM CM C^ O 00 . V _O OO in rO H CO VO VO H VD VO O CM ro r r in r- rxi in in ro t— cΛ H <Λ ro ro r- c <Λ t- r- oo ro cM in oo ιn vD VD H r- c» co cM CM co H co cM T τ CΛ 00 VD 0o0o o o co vo r- σi r— co ro oo cn r— cΛ H oo vo ro r- ro vD VD o τ r- ιn ιn ro cD H H Vθ ro cΛ eo ιn H CΛ in r- oo o τ oo cM -τ r- H i VD T VD C CΛΛ H CΛ O O CO m OO rO VO VD VD O oo t- H oo vo vo H θ vo ^ H θ o r- rx> vo oo cM r- cn H vo cM ro cn vo cM "3^, o vo cM Vo σι ro <Λ in cM in ^|_ι r-

00 I— I— 00 CΛ CΛ 1— vo r- r- oo cn o H O r- vo vD vD VD oo T T i- CM CM ro ro T 1< H CM o en o CM CM ro ro T co co t- vo m in vo in vo vo vo m in rH rH rH rH rH C^i C^ CSl rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH H H O H H H H H H O OO OOOOOOOO OO

o o o o o o o θ H H H H H H H H H CM CM CM CM CM CM ro ro n ro ro ro ro ro ro ro ro τ τ τ τ τ τ -τ *τ r ^r ^jι ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn cn cn cn cn cΛ cΛ CΛ cn cΛ cn cn cΛ cn cΛ cn cn cn cn cn cΛ CΛ cn cn cn cn cΛ cΛ cΛ cΛ CΛ cn cn cΛ cΛ cΛ cΛ cΛ cΛ C^ oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H H HH H H H H H H H H H H H H H H H H H H H H H H H H H HH H HH H H H HH H H H H H H H H H H H H H H H H H

CM C_ C_ l_< C_ a e_ I_i D D D D D D D D D OT -5 W W OT W W W t

V) W U} Cq <q <n Cn U> rl rH H rH rl r rl r4 4 X X X X X X X X X X X rti rt; < rt; u o c θ θ u u ϋ u υ υ u u υ υ c_ c_ cu cu c_ c_ c_ e_ cu CM _ 4 ι _ c^ rH CM rH CM H CM τ-i CM M CQ CD Q Q rtJ CQ CD Q ω ω rtJ CQ CD cQ CD a a ωω sι H CM rH CM H CM H C rtJ CQ CD Q Q W td t. rti ao Q Ω t-i ω ) ocj u o o υ o z υ υo cj o o u o z u uco u o z O O CJ O CJ CJ CJ CJ CJ o z υ ucj cj u c cjcj c o z J U U CJ CJ CJ CJ CJ CJ O

_i -⁾ r- cn c θ H CM ro τ ιn vo r- ci⁾ CΛ θ H C i c 'τ ιn vo r- c j Λ θ rH C r ^ ιn vD r- oo cΛ θ H CM Cθ 'T in vo r- rΛ CM CM CM CM CM fO r r ro ro ro r r rθ '*-, ^,--r τ 'τ ^,τ 'τ ^,-^ι 'T 'τ ^ ΦΦΦΦΦΦΦΦΦΦΦΦΦΦΦΦΦΦ ΦΦΦΦ Φ ΦΦΦΦΦ Φ Φ ΦΦΦΦΦ ΦΦφφφφ φφφφφ φφφφφφφφφ H H H rH H H H H H H H H H H H H HH H HH HH H H H H H H H H H H H H H H H H HH H H H H H H rHH HH H HH H H

00 rH O Σ ooΣ ΣΣ Σ ΣΣ Σ

© o ΣoΣooΣoΣΣoΣoΣ EHoΣ H HooΣ EHoΣoΣoΣ E^H EH EHoΣ EHoΣ EHoΣ EHoΣ EHoΣoΣ EH HoΣ EHoΣ EHoΣ HoΣ H EoHoΣΣ EH EoHoΣΣ EHoΣ EHoHoEHoΣ EHoHoEHoΣ HoEHoΣΣ EHoΣΣΣΣΣΣ∑∑∑Σ∑ΣΣΣ∑∑Σ

H EH EH E^H H H EH H EHoEHoEHoHoHoEHoEHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEH

O ft f f t ft ft tt tt tt ft r f $ ft f f£ t f£ f$ ft f t tt tt ft t t t t ft tt ^ it

co cvi o ιn cM in H cΛ τ ro <Λ o ro vo r- cM T o o oo -<- o oo T r- vD cn vθ oo cΛ CM ro r H θ τ co t— OO O T r- oo is¹ in m ^■-> CΛ in o ι→ CM CM in ιn r- r- r- r_) H VD CM CM CM CM CM CM CM CM CM rO CM OOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOO rH rH rH rH

CM H CM H in r- oo cM τ o co vD H cΛ τ cΛ CM m vo r- r- m cM H H ro » _ θ -i w o O O T CΛ CΛ in H tO O m O OO O O CM CM in CM H ^ O in •sji co co CM in r- o r- in en o r- cM r- ro oo vD VO in m ^i' Vo ro cn T oo H oo vo cM CΛ H in r- vo ro o cΛ m o H ro H m oo vD T co D in co oo H CM CM O CΛ OO VD T H CΛ CM in VD m OO r- rO rO O CΛ CM OO H in ^ Λ CΛ m H CΛ OO CO H H in OO ^r O r- CΛ r- r- H rΛ CΛ H T VD O CM

H H O O H O H CM O CΛ Cn CΛ CΛ CΛ Cn CΛ oo r- oo r- co r— vo r- r- r- ιo m τ τ m vD vo τ ^< τ τ τ ro cM CM CM θ cn o H θ o cn cM CM H CM ro

T T T T T T T T T ro ro r r r ro ro ro ro ro ro ro ro ro ro M M M M ro ro ro ro ro c n ro ro ro n ro ro ro ro cM ro ro ro n cM ro ro ro ro co t— ro ιn cn vo ιn cΛ r- cΛ vD τ vD rθ H ro ιn cΛ cM in o H H r- τ vo c» τ vo vo cM VD in cn ιn r-- H r- ιn vo o cΛ vo vθ (η M ^ o o ro ιn H Λ H CM 00 r^» o ω ^ ιo N ^ 'f ι ιIl ω (^ι ι^ι ^ ιΛ H ffl ^ r o> ^ O H Oi o ιΛ lf ^■J f Ol t 'f Ol co » co (^ N r• ιl1 fl H « H '^ι ιJl ( 0 <^ ^•» o ro cn oo r- oo cn co

VO ιn -τ rO CM H H VO CO Vθ r- CX) CΛ H H H H CM VO VO VD in 'T *- t (η VD r- r- C» <Λ CΛ O H H C» r- CΛ CΛ O H CI) C» ∞ CD CD ∞ CM CM CM CM CM CM CM CM CM CM CM CM CM rO rO rO fO rO CM CM CM CM CM CM CM CM CM CM CM CM CM CM rO tO rO CM CM CM CM C n r- ro ιn co t- Λ r- vo vo σ^ c_ι θ r- ιn o cM cn ιn ^ oo H CΛ H VD θ H CΛ H σv ιn cM Cθ in cM CM in ιn H θ CM in c ιn ιn ιn σι oo cΛ tθ H V^ T -r o o oo in o Λ in cΛ in cΛ in H tn in vo ro co H O cn in in t— ιn ro ιn H θ <Λ τ cθ H in ro vo co ro cn o vo cM VD H oo vo e» ro oo o o ιn cM cn co i H in vo o θΛ ro co o ro co ro ro o cM CΛ CΛ o cD vo cM in vD r- vD r Cn cΛ cn τ oo vo o cΛ θ co 'τ o vD ro ιn τ cM CM ro ^ 'τ r- cD ιn « ^^, '- ro ro ^r ro cM CM H H o o oo r- co vo o H θ^>ι oo r- vD r- ιn r- vD oo r- oo vD vo m τ ro τ ι. ro ιn ιn co r- r- oo ιn m vD vo ιn oo ro

O O O O O O O O O O O O O O Cn cn cn cn o O CΛ Cn cn cΛ CΛ CΛ CΛ CΛ CΛ CΛ C CΛ d σi ^ 0^ σi Λ O CΛ CΛ O CΛ Λ C C CΛ C eΛ CΛ CΛ CΛ

Φ Φ Φ i- t- t^ ι- ^ ι- ^ ^ r^» r^ ω co co _ co ω o oo σι m ijι σι crι Λ n crι w o o o o o θ H H ri H ri H ri H [\i (\ (vi (vι r>ι

01 ⁽yι ⁽Tl 01 ⁽Jl ^ 0\ 0^ ⁽Λ fli σi ⁽Λ £Λ 01 (Λ (Λ 010\ ffl CΛ 0Ϊ (Λ 0101 C1 1 fft Φ ⁽Mrι fl 0101 <Jl 010MJl O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

D D D D D D D D D C5 O CD CD CD O C5 O CD CD CD D D D D _3 D D D D _3 D D D D D D D 0, l_; cc; 0, C- C_ Z Z Z Z Z Z Z Z Z Z Z Z Z

H HH^, HH HH HH HH HH HH' HH HH tf pH C_ e, pH e_ pM OH < pH U U U u . u u ou u uo ^ < ^ _l< fl; j j ιj j _hq ι j j (5 o u u uuoø θ_toιn ₁oto mo) rti rt; < < rt vo r- oo cΛ θ H CM n τ ιn vo CM CM CM CM ro ro ro ro ro ro ro r- r- r- r- r- r- r- r- r- r- r- rH rH rH rH rH rH rH rH rH rH rH

ΣΣΣΣΣΣΣΣΣΣΣ ooooooooooo fiC rtJ rtJ rtJ rtl rti rtJ rtl rtl rtl rt;

Table 6

ATOM 1737 ND2 ASN 1102 93. ,124 24. ,297 131. 125 1. 00 32. 71

ATOM 1738 C ASN 1102 97, ,803 24. ,331 132. ,180 1. .00 22. .35

ATOM 1739 O ASN 1102 98, .130 23. ,152 132. .074 1. ,00 22. ,20

ATOM 1740 N TYR 1103 98, .676 25. ,321 132. .109 1. ,00 21. ,25

ATOM 1741 CA TYR 1103 100, .098 25. ,064 131. ,960 1. ,00 21. ,42

ATOM 1742 CB TYR 1103 100. .707 25, ,993 130. ,904 1. ,00 21. ,03

ATOM 1743 CG TYR 1103 100. .594 25, ,458 129. ,486 1. ,00 21. ,58

ATOM 1744 CDl TYR 1103 101. .568 24. ,605 128. ,961 1. ,00 22. ,58

ATOM 1745 CEl TYR 1103 101, .460 24, ,083 127. .672 1. ,00 22. .23

ATOM 1746 CD2 TYR 1103 99, .501 25. ,775 128. ,683 1. ,00 20. .55

ATOM 1747 CE2 TYR 1103 99, .383 25. .257 127. ,390 1. ,00 22. .04

ATOM 1748 CZ TYR 1103 100. ,364 24, ,415 126. ,887 1. ,00 22. .33

ATOM 1749 OH TYR 1103 100, .263 23. ,922 125. ,596 1. ,00 21. .39

ATOM 1750 C TYR 1103 100. .627 25. .424 133. ,326 1. ,00 21. .79

ATOM 1751 O TYR 1103 99. .947 26. ,096 134. ,076 1. ,00 23. ,68

ATOM 1752 N ASN 1104 101, .819 24, .971 133. ,669 1. .00 22. .54

ATOM 1753 CA ASN 1104 102, .387 25, .299 134. ,970 1. .00 23. .11

ATOM 1754 CB ASN 1104 102, .982 24, .061 135. ,641 1, .00 21. ,78

ATOM 1755 CG ASN 1104 101, .953 23, .244 136. ,358 1, .00 19. ,51

ATOM 1756 ODl ASN 1104 100. .761 23, .516 136. ,271 1. .00 18. ,29

ATOM 1757 ND2 ASN 1104 102, .408 22. .228 137. ,075 1. .00 18. ,41

ATOM 1758 C ASN 1104 103. .484 26. .325 134. ,815 1, .00 24. .80

ATOM 1759 O ASN 1104 104, .102 26, .442 133, ,757 1, .00 25. .15

ATOM 1760 N THR 1105 103, .729 27, .067 135, ,883 1, .00 25, .84

ATOM 1761 ^' CA THR 1105 104, .776 28, .060 135. ,863 1, .00 26, .64

ATOM 1762 CB THR 1105 104. .186 29, .483 135. ,731 1. .00 25, .73

ATOM 1763 OG1 THR 1105 103. .226 29, .720 136. .765 1, .00 27, ,01

ATOM 1764 CG2 THR 1105 103. .513 29, .634 134. ,389 1, .00 25. ,56

ATOM 1765 C THR 1105 105, .588 27, ,909 137. ,141 1, .00 27, ,82

ATOM 1766 O THR 1105 105, .038 27. .824 138. .242 1, .00 27, .80

ATOM 1767 N TYR 1106 106, .902 27. .849 136. .981 1. .00 28, .80

ATOM 1768 CA TYR 1106 107, .792 27. .697 138. .118 1, .00 30, .47

ATOM 1769 CB TYR 1106 108, .760 26. .553 137. .832 1, .00 29. .61

ATOM 1770 CG TYR 1106 108, .023 25. .253 137, .768 1. .00 29, .12

ATOM 1771 CDl TYR 1106 107, .828 24. .493 138, .914 1, .00 30, .78

ATOM 1772 CEl TYR 1106 107, .020 23, .362 138, .903 1. .00 30. .90

ATOM 1773 CD2 TYR 1106 107, .397 24, .846 136, .597 1, .00 29, .58

ATOM 1774 CE2 TYR 1106 106, .583 23, .720 136, .572 1. .00 30, .55

ATOM 1775 CZ TYR 1106 106, .398 22, .984 137, .734 1. .00 31, .06

ATOM 1776 OH TYR 1106 105. .583 21. .881 137, .740 1, .00 31, .17

ATOM 1777 C TYR 1106 108. .525 29. .000 138, .393 1, .00 32, .52

ATOM 1778 O TYR 1106 109. ,573 29. .273 137, .806 1, .00 33, .70

ATOM 1779 N ARG 1107 107. .954 29. .805 139, .286 1, .00 33, ,59

ATOM 1780 CA ARG 1107 108. ,519 31. .098 139, .637 1, .00 33. .71

ATOM 1781 CB ARG 1107 107, .395 32, .094 139, .922 1. .00 34, .16

ATOM 1782 CG ARG 1107 107, .888 33. .456 140, .363 1, .00 35, .95

ATOM 1783 CD ARG 1107 106, .743 34. .421 140, .627 1, .00 37, .06

ATOM 1784 NE ARG 1107 105. .738 33. .845 141, .517 1 .00 39, .01

ATOM 1785 CZ ARG 1107 104, .896 34. .553 142, .264 1, .00 38, .49

ATOM 1786 NHl ARG 1107 104, .929 35. .878 142, .238 1 .00 38, .07

ATOM 1787 NH2 ARG 1107 104, ,028 33. .930 143, .048 1, .00 38, .62

ATOM 1788 C ARG 1107 109, ,439 30, .998 140, .835 1 .00 34, .38

ATOM 1789 O ARG 1107 109. .050 30. .486 141, .882 1 .00 34, .01

ATOM 1790 N SER 1108 110. .662 31. .498 140, .678 1, .00 35. .71

ATOM 1791 CA SER 1108 111. ,642 31. .450 141, .759 1, .00 38, .01

ATOM 1792 CB SER 1108 112. ,977 32, .060 141, .337 1 .00 39, .41

OO H CM O O O VD O Cn m H T C .M . θ ιn <η vo vo ιn 'τ ro ιn o cΛ ro H θ^ H CD θ r- uι ro < <Λ o <Λ r '- θi θ rH cΛ o cM <Λ co o cM co r- r- -τ H ro ιn co cΛ co H r- ro o o r- oo m cM m ιn tr—- τ H vo σι vo o^ H in ιn ιn <Λ ro τ τ cD θ o cn cM CM θ ιn o oo cΛ ιn ro vo cM rH co ro r- r- t— T CM o CM CΛ ro cn r cΛ C H PO T r- in o ro c oo ccDD min τ cD in cM r- ^,τ cΛ CΛ ^ vo r- r- rθ 'τ o <» ιn ιn cM CM θ H cn o cM rθ VD ^ t- ιn co ro cM H ^ ro ro τ r- co o H

CM CM CM ^ in VO t— ∞ CΛ O H O in VO ιn in in VO r- rX) CΛ T in CO CM rH CM rθ «- H CM rO '. CM H OO CM T ^,<3' in H O OI OI O oo r- oo r- l— r- r— r- oo r-

"sj^{1 •}_^■ ro ro T ro ro ro ro ro ro ro ro ro ro

H H H H H cn o cn o H H ^ o ^ H Φ Φ CD ln o ^ » ^ ^ v ^■sr vΦo r^- oo ^c- mιn ιιnn <eJnι oo oo vΦD CNM C0M 'v3' ιinn nro ιιnn vΦD CNM C_Λ ΦVD oωo o_o cΦo r^- c_Λ ΦVD ΦVo v-o c»Λ iιnn ccM^l rrHl oo H H r-ι CΛ 00 CD CD T Λ » o v o « oo o ιn ^ H ^ N in T<r oo rr-- iιnn -vT tiΛJ oo ιcsΛ om> ocoo cαoι r- t— ιinn oo HH fl-- <'τι^| Nc 'τi^| oo rr-- '^» rr-- cιoc ιιn o(θo HrH τiι i()Λi HH HH ViDD it) ^ oι ιn o H ro <- o cn ^ r ^ r cΛ T H o cn c Λ in o vo H C O H H CD ro c in H oo ^ si H ro c o ro cM ∞ r- T Λ T H r. in H 'T 'T t— o -T C CΛ

CM CM ro H CM O H O cn cn cn cD c^ T CM ro ro ro rO T ro in vD in vo vD in vo in T T 'T T VD VD vD VD t— OO VD VD VD Γ— t— Ol o t-^» Φ ιn m Φ ^ _ Φ ^ ro ro n ro n n ro cη cM CM CM CM ro n ro ro ro in ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro M r

H H m ffl <ll _ ω H ^ N co ι H » lJ H llo ιη ιn ^^ ^ (J O ^ ^ o ^ (^ι β 1J H H β lI) H O ^ H ιn w « cΛ (^ι (^ι o ^ o n (^ι ^o ιn ^ ι o tl co a ι^ N co r) H n ιn ι ) eo o ^ αl ιη !D ιn Λ Λ O (^ « N 05 ln ^ <^l ln l» Ol ι ι n H ^o m ra N H O ^ ιn H <» o o ^ fl ω ιo N ln ln ιη i m H m ri lO in m fn m i i — Ln lo ro m m m nι τιι . ι — m in r-i n r-i rri rn r-i f-i p rM rr—- moo iinn mro ivOo HH mro moo iinn min droi ΛcMi iVoo fieΛi ΛCMi HH rr—. * - fl*i in- - — — — _ - rO H O H O O CΛ CΛ O O CΛ H H H CM ro in vo vo r- r- ro rO '- ro in vo vo oo r- co co cn cM CM H o oi oi oi cn co o oi oi o^ o d o H CM CO «-' in CD CM H H H rH H H O O H H O H O O O O O H O O O rH O H

H H H H H H H H H H H H H

oo oo oo cn cn cn cn cn cn cn cn cΛ CΛ cn o o o o o o o o o H H H H H H H H H H H H CM CM CM CM CM CM CM rO rO rO rO CO rO T 'a' T T H.' TJⁱ T T

O ι O-ι r O-. r O-> o θ O O O O O O O O H H H H H H H H H H H H t rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH

DS Dj (H U - - O U _{- -} _ O θ - _ m C C W W !O I_ , C- θ; θi , Λ θ. (ϊ β! C- l_ B; tι! α4 c£. pύ oc; pύ α; pς pc; ύ ύ α. ij ϋ βj CLι αι Q< αι f-ι tιi [ιi [ιi (r; tt; o! (, (i! [ζ ι. ιι; (t; ιι; Λ ι >ι χ >< ι ( >ι 4 ι ι ι >ι χ >ι χ ( >H ι >H >( ₎ a: a; O C O rtl rtl rtl rtJ rtJ rtl rtl rtl ^ rtJ rtl Hj Hq HH HH HH HJ HH HH HH EH EH EH EH EH EH EH EH EH EH EH EH EH EH x x x x x ω ω ui ω ω ui oi oi c& cύ cύ cύ cύ oi

H CM H H CM CM H CM CM CM rO rH

CD < α Q U N X X tt ω CD Q ω SJ < (g . Q U Q U lSI „ r- CQ CD O ft CQ CD «; CQ CD Q ω ω Q

O U O Z CJ CJ CJ CJ Z O Z Z oozuuυυcjzυo uououuυυouozuυoc o o z uuouo Z U O CJ U CJ CJ O n ^ ιn ω ^ o3 m o H ι n ^ ιn Φ ^ ⁽D _ o H N n « ιn ^ eo ol O H N n ^ l ) ^ α⁾ l!l O ri N n ^ ι ι ω oo m o H ( ιη ^ ιn ^fl _

CΛ CΛ cΛ σ CΛ CΛ CΛ O O O O O O O O O O H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM rθ rθ r rθ r rθ rθ r r r T T 'i-r T T T 'T 'T T ^ ^ ^ ^ m∞ _ ω _ _ ω ω _ _ ω _ ωω _ _ _ ω _ „ oo ω ooω _ _ ω _ ∞ _ ωω _ _ ω ω _ _ ω _ ω ω _ a) _ ω _ _

H H H H H H HHH H H H HH HH H H H H H H H H H H H H H H H H H H H H HH H H H HH H HH HH H H H H HH H H oo o ΣoΣoΣΣoΣoΣoΣoΣooΣΣooΣΣoΣooΣoΣΣoΣoΣooΣoΣΣooΣΣΣΣΣΣΣΣΣΣΣΣΣoΣΣΣΣΣΣΣΣΣΣ Σ

-H tH EH EH EH EH EH EH EH EH EH EH H EH EH EH tH EH EH EH EH EHoEHoEHoHoEHoHoEHoEHoEHotHoEHoHoEH EH EoHoEHoEH EoHoEH Eo ΣΣΣΣΣΣΣΣΣΣ HoEH EoHoΣ EHoEH EoH EoHoEHotH eoH toHoEHoH EoHoEHoEH o tt ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft tt ft ft ft tt ft ft ft tt ft ft ft ft ft ft ft A it

o rt r- •Si ro -i in oD rg n cM *. in i- in o r- in t— o cn VO o CM O T O T I— H ro cn r— vo T o in T T r- CM t— CM cn H t- r- t— co T O vo cM oo co cΛ cn co o s CΛ T CM ΓO ΓO H H H cn in CM r- T T VD vo «, r- *ιjι in CM T CΛ CM OO C— O ιn τ T ro oo vo ro H co H in in T T cn o in oo H O oo cM T CM t- vo co co

© o vo vo vo r- O CΛ O cvι ιη ιηN n ^ ( ^ ^ ι n H O H r1nn ^^vn( ^ Φιn ιn ιn ιn ^ ^ o m » H ^ M n ι ιn Φ ι-• ^ ^ ^ co om

CΛ *-J i- T T T ro T

OOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H OOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO U

PM H H H H H m cΛ oo o m r- vo r c oo Λ CΛ CD H vD i en vc in o cD cM -T OO '- r- T in r cn cM CM r T H CO CΛ lΛ CΛ O H H r- r- e» co r- co cD O cn oo oo oo r- ro ro ro co ro ro ro CM H H rH H H

HHHHHHH in r- cΛ cΛ vo H T CM VD CΛ lD H r- oo H CM CM r- cn ro cΛ o cΛ CD o o CΛ H CΛ ro rΛ ro t— cn cΛ H H O ro oo ιIl ra ι n oo ro ro ro ro ro ro

'f v v σl <Jl o o o o o o o o o

H H H H H CM CM CM CM CM CM CM CM CM H H H H H H H H H H H H H H H H H H H H H H H H H H H H

O^j C f^ Q- O' C^ pϊ Cή oS ri cS Λ tf S & βi CS CCj Hq H^ HP HJ H^ i-l i-l tt ft ft ft D D D D D D D D CO CO CO CO CO CO CO CO CO CD CD CD CD CD CD CD CD CD Cύ Cύ Bi Cύ Cύ Λ X X X X X X X X X X X X et ft < ft fC, ft f HI H! H] H .1. u) u ω ω ω w iύbi x x x x x x x x cύ a: c Qi oi X (*: c*i cύ E^H EH E^H E^H H EH E^H E^H E^H E^H EH EH E^H E^H EH EH EH EH > > > > > > > ft ft, _ft l H- r l 4 rl H l 4 rH- rH^, rH- rH- rH- l rH- rl < e ft t tt <

H CM ΓO CM H H CM CM H CM H CM H CM ω sι tsi _3 AϋD U Q U Q U N X fiC CQ O CD riJ CQ fiC CQ CD Q Q tt co C a ω si rtl OQ D Q M N DC K z υ oo u o z u υ υ u o cjcj cj o υo z cj cj υu u o z oooo z o υυυ u cj O Z U O O CJ CJ Z υ o z u u υ u z c z z ιη . o o σισ) HH

Tt rt r- r en o CM oo o r- τ r- t— ro vo vD CM Co co cM co ro H ro T CΛ CM ro ro oo in o o vo in o cn co oo cΛ in r- CM H CΛ co in co cΛ co cΛ t- CM H OO CΛ OO CO ΓO VO r-j m CΛ vo H o oo ^. ^r vo cM O C CΛ in o in cΛ in oO T C r- r vD cΛ O H Co ro ' t-- σι ιn o cn o vD τ oo o ιn r- vD CM VD oo θ "- r- ro m r- ro τ H -τ o

© © 3 vo t^ in m t— oo ^ n ^ v ^ t^ •<^ ln Φ ω (ι ιn (η r (η (η ιo (^ Λ ιn ιn ι ιn ιn v n ιn ιn ^ H ιn ^ ιn ιn ^ ιn ιn ^ r ^■4^, o ^ ^ ιn ι CΛ *^ _'^ _'T _'^ _'. *!]' ij ^ ^ ^ ιϊ ^ ιr ^ ^ ^ ^ ιπ ιn ιn ^ M^, ^ ^ ^ 'j ^ ^ ^ ^ ^ ^ iϊ ^ ^ ^ ^ ιn ιn ιn ιo v ^ ^ ^ ^ ^ ^ v ^ ^,* ^ ^ ^ ^^{, ,}3^|

O O O O O O O O O O OO O O OO OOOOOOO OOOO OO O O O O O O OO O O OO O O O O O OO O O OO O o o υ O OOO O O O OO O OO O OO O O O O O O OOOOOOOOO OO OOO OOO O O OOO O O OO OO O OO O o o

PM H H H H oo o o in oo oo en m r- r- o ro vD CM co H oo ro r- oo oo ro m T ia O m O in r— t— rH T H H t— r— rH CΛ O oo oo co cn o vo o in cM cn cM cn o T T t- O CM OO m t— O O CD CΛ CM O rO CΛ O CΛ O Cn '-r' VD CM CΛ CΛ . . ^ .r o _ m. o_o v _o o _o. T . C _Λ . CΛ cΛ ro ro in cΛ oo cM m vD in r- r— t— o in c cΛ io c T T c vo r- cM vo vo cn r- in H in ^i' vo ro r- cΛ ro vo co m r- oo ro o o ^ji oo O T CΛ ro vD o vo r- T CM t— ΓO CΛ H in m m i— ". o cn H T Oo r- in co H ro

CΛ H O O H CΛ H H C rO ^ in ^ i in ^ in VD 'T VO D OO C O O H H O H H C ∞ r- Cn cn cO CO t— r- VO O H O H H H O CM CM rH t T '^ '!. '!- H CM Cil CM CM H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM ro n rO C^ CO rO M ro CM CM CM CM C^ CM CM CO C t— r- rH m CO ^lV-o ΦvD ΦD co ro ro i- oo co vD r— O TT C-Λi o o co co τ vo r- r- vo vD r- ιn vo r- r- r- oo cΛ θ H H H r- VO r- VD r- OO OO O CΛ H H CM VD t- CD VD T T ro cM co vo in r- r- oo cn o o vD m vD 'T T ro m

H H H H H H H H H H H H H H H H CM CM CM CM H H H H H H CM H CM CM CM H H H H H H H H H H H H H H H CM CM rH H H H H H H H H

H M H H H C C CN CM ro ro co ro ro r ro ro '-T ^ 'T '- 'T T T T T T T .n in i in in -^

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

HH H HH H H HH H H H HH H HH HH H H HH HH H H H HH H H H H H HH HHH HH HH H HH H rHH H H

H H H HH H H HHH H H rHH H H H HH H HH H H H H H H HH H H H H H HH H HH HH HH H HH H HH H H ι) {3 c£ cύ e6 ύ cύ ( ςύ χ χ z z z ai (ύ cύ cύ c cύ cύ cύ (ύ 6 cύ cύ v) ζΛ <Λ w

Cύ X X X X rl rl r rΑ ri ^ r rΑ rΑ r r rl rl X X X X X X X X X X ω ω ω iύ a iύ lύ Ui r rH r Ui rtl H -H EH EH H EH H O O O O U C O O C O U O EH EH lH EH EH H EH EH H H EH EH HH HH- HH rH rH HH- J

H CM H CM rH H CM CM H CM ft CQ CD CD ft tt CQ CD α w ω rt! cQ CD Q ω α ω sι :_. < CQ CD Q ω ) ft ω CD Q Q ft

CJ o z c cj o ooo zcj o o zuuυuo z uoz υ υ υ o υcj o υoυo z ouuuozuoz υυuoυ c o z υ υ o

rt rt t- ro •5T r- ^•-¹ oo H m r i— C in ro CΛ <Λ H t— o τ σι CM τ o ro m m o ιn r- CM θ τ co τ m cM oo o vD ro vo ro r- ro m vo cM τ H CΛ CD CM CM CO O H CΛ s H co o ro ro T 00 O 00 T CM CM O in VD in H T H VD OO r- O O H rO O VD Λ OO r— CΛ VD r- CM <Λ CM r- <Λ T T VD t— T CΛ O T CN CO CO T _'._' T CΛ VD

© © 3 t— oo o r- co r- vD r- r- oo oo t- vo vO '-i' ro ^i' in ^r H o o o cn o o o cn O O H O O O O CΛ 00 CΛ H CM ro cM oo oo i— m vo oo cn cn cn in tn ' T

CΛ T T T CO T T T OO T T ro ro ro ^ T T T ro ro ro ro ro ro co ro ro ro ro ro ro

OO O OO O O OO OO OO O O O OOO OO O OOOO O OO OOO O O OO OO O OOO OO O OO OO OOOOO OO υ O OO O O O O O O O O OO O O O OOO OO O OOOO O OO O OO O O O O OO O OOO OO O OO OO OO OOO OO

_H H H H H H

CM O co ro r— t— cr> τ H t— ro vo o τ ιn τ co t-- τ O O CM oo cn H CO oo ro o m cΛ in H H r— ro oo t— ro in c— T O VO Γ— t— cΛ CM CΛ T H H t— CM CO

H CΛ CN H H CM CM OO m rO r- O CO T CM in VO CO H ro τ ro ro t- H rθ H r- ιn r- CM cn o <Λ o cM θ vo ro o ro cM ro t- oo cn t— cn in ro r- co cΛ CΛ H

CM H ro cΛ r- O r— m t— CM 0O "-ji VD VO r- r- t— o m r— r- o oo c vo ro iD rθ H CM H C θ θ o m t— H cn o cM <Λ VD m τ H VD H o H^ " vo^, " r-- ' C^Λ C^ΛΛ in~

<» ιι ^^ ^ι ι ^ι o ιJl ffl ^ ιo ιn o m H H ι v t! (^ι N H N H O N ιη ( π π H H O ι^ co ^ ι^ι ^ co ^ (» ^ » ^ co ^O Λ ^ fl N N O lo ^tι ^ co ro n ro ro m ro cM CM CM CM CM ro cM ro ro ro oo ro ro co n n ro m ro r co r^

H in rO CM ^ rO T CM CΛ CM VD OO H CΛ VD H CO H VO i-l in 'J' in H H CΛ t- rO rH H CO H CO CO t— vo co oo θ '3' in vo ro o H vo σι o o σι ro o ι τ H CM VO OO O CO CM CO VD r- VD 00 H r- r- r- C0 ^J< <Λ H H '3i ^< C0 H ^ι CM θ r0 CM T θ m 00 H r- r0 T VD r- CM t- m τ σi H CΛ oo σi co o in vo cM ro ro σi ro co o r- oo r- cn ro ro o vo τ cM ro m oo r- cM oo oo oo T CM vo t— o co m vo oo cM i— l o co co m ^i m vD O C C r- O in ^ O CO T T CΛ CO CM O CO O ω ro ω ω h r- ^ ^ ω ω Φ Φ ^ t- Φ ιn Ml ln (^ Φ ^ Φ ^ vo ιn [--• co Φ r• ω Φ ι t-- Φ ιn ιn ι M' ^ Φ -) ιn Φ ^^ c^l cvι H O <Jl <Jl r^■ ^ o ^Λ o o ro ro ro ro n ro ro ro ro ro ro ro cη ro c ro ro co ro ro ro ro n ro ro ro ro ro ro m ro ro ro ro ro

V

H o H vo o CM ro oo ro t— T H CM VO O H Vo cM ^ CM CM T t- oo oo ro H oo oo oo ro o o o r- H i- ro m oo H r- cn co o in cM cn r- CM cn co ro cM vo V T t- oo ro t— co vo τ oo co cM 'a^, m ιn vo vo r- -" CM τ o m o m cΛ r- o τ t— VD T O O CO r- H r- θ H r- oo ro oo r- H H H oo τ ιn τ co o τ i t- H CΛ O VO CO CN O co t— ro ro oo H τ H H CM ro o cM oo vo ro H CM ro <Λ H cn cM vo τ co ιn r- co o r- CM oo r- CM Vo in ro cM H O rH T T CM VD r- in r- r— ιn τ τ τ m ιn m vo vD CM CM CM H H H CM o o oo r- vD vD in in ro ro ro ro cM ro cM ro ro T in r- r- cn cn cΛ m τ m m m ιn ιn m ιn vo vD r- co

H H O OO O OOOOOOOOOOO OO O OO O O O O O O O O O O O O OO O

H H H H H H H H HH H HrHH H HH H H H H H H H H H H H H H H H H H H H H

oo oo oo α3 c^{) C}Λ <Λ < c cΛ cΛ c c eΛ o o o o o o o H H H H CM C M CM M CM CM ro o r r τ ^ τ 'τ r 'τ τ τ τ ιn ιn ι ιn ι ιn ιn ιn ιn ^ cM CM CM CM CM CM CM CM CM CM CM CM CM CM ro ro ro ro ro ro ro ro n ro ro ro ro m ro ro ro ro ro co ro ro r r M

H H H H H H rH H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H rH H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

⁽ ωⁱ! lω>! Bω; ⁽ωl! lωl! W_H W>_H WH n>_H n>_H w< n_H i>⁽⁾ _H w>_H ea_; BHC! BHr!. c_r,r. ⁽ _rri!_j B_a:i l_B>! >jⁱ j >ⁱ- i| O^ O_oi O_c≤ O_|^ O₀^ O O < < < < Z Z Z Z Z Z Z Z Z co co co co co co co co co fiC X X X x x ,_) O _ θ H^ H^ H5 Hj H^ H^ H^ H^ J EH EH H H EH EH EH θ O CD ϋ Dj CU C_ Cu j C C θ O O U U C_I O H J J IH IH HK

H CM H CM

< m ft CQ CD Q ω S3 rt! CQ CD CD ft Q rti OQ CD tt tt cQ CD Q ω ω ft ω CD Q b, i CJ CJ o υozυυcjuc z cjozυc ooυozcjooz υυυuυ o z oυozcjc uυozυo Z CJ CJ CJ CJ CJ Z O O

H N ιη ^ ιn » co w o H ⁽! n ^ ιn ω ^ αl ιJι O H N M '-f ιn a ^ flo Ol O H N tn ^ ιn ω ^ (D m o H N π ']^| l » ^ ∞ m o H ι ιη ^ι' ιn -

VO VO VO VO VO VD VO VO VO r- l^ t- r- (- t- t- r- r- r- 00 00 00 00 00 00 C0 0000 C0 CΛ CΛ <Λ (Λ CΛ CΛ <Λ CΛ CΛ CΛ O O O O O O O O O O H H H H H H H ⁽Λ CΛ CΛ CΛ Cn cΛ CΛ CΛ CΛ σi CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ Cn CΛ Cn cn CΛ σi CΛ CΛ Cn Cn Cn Cn CΛ CΛ Cn cΛ CΛ CΛ CΛ O O O O O O O O O O O O O O O O O H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN

00 rH rH rH o ΣoΣΣooΣoΣΣooΣΣooΣoΣoΣΣooΣoΣΣooΣoΣoΣΣoΣoΣooΣΣoΣΣ Σ O ooΣoo∑o∑ΣoooΣΣoΣooΣΣooΣΣooΣ∑oΣoΣoΣooΣΣoΣooΣΣoΣoΣoΣoΣooΣΣoΣooΣΣo o

Table 6

ATOM 2017 CB ALA 1136 110, .020 30. .921 127. ,415 1. ,00 34. ,51

ATOM 2018 C ALA 1136 108 .558 29. .619 128. .953 1. ,00 33. .97

ATOM 2019 O ALA 1136 109 .147 28, .619 129. .357 1. ,00 33. .77

ATOM 2020 N ILE 1137 107, .733 30, .334 129. .710 1. ,00 32. ,70

ATOM 2021 CA ILE 1137 107, .476 30. .010 131. .113 1. ,00 32. ,21

ATOM 2022 CB ILE 1137 106, .915 31. .254 131. ,857 1. ,00 31. .38

ATOM 2023 CG2 ILE 1137 107, .975 32. .348 131. .928 1. ,00 30. .84

ATOM 2024 CGI ILE 1137 105, .645 31. .745 131. ,146 1. ,00 30. .94

ATOM 2025 CDl ILE 1137 104, .820 32, .734 131. ,927 1. ,00 29. .44

ATOM 2026 C ILE 1137 106. .491 28, .857 131. ,361 1. .00 31. ,36

ATOM 2027 O ILE 1137 106, .534 28, .202 132. .403 1. .00 32. ,48

ATOM 2028 N LEU 1138 105, .609 28, .616 130, ,404 1, .00 29, .32

ATOM 2029 CA LEU 1138 104, .588 27. .597 130. ,554 1. .00 28. ,65

ATOM 2030 CB LEU 1138 103, .480 27. .870 129. ,540 1. .00 29. ,90

ATOM 2031 CG LEU 1138 103, ,086 29, .350 129. .460 1. .00 29. .89

ATOM 2032 CDl LEU 1138 102, .268 29, .600 128. ,209 1. .00 28. .56

ATOM 2033 CD2 LEU 1138 102, .333 29, .759 130. ,730 1. .00 29, .29

ATOM 2034 C LEU 1138 105, .090 26, .172 130. ,414 1. ,00 28. .55

ATOM 2035 O LEU 1138 105, .711 25, .822 129. ,413 1. ,00 30, .20

ATOM 2036 N PHE 1139 104, .822 25, .344 131. ,420 1, ,00 27. .45

ATOM 2037 CA PHE 1139 105. .247 23. ,948 131. .368 1. ,00 26. ,67

ATOM 2038 CB PHE 1139 106. .353 23, ,650 132. .377 1. ,00 27. ,49

ATOM 2039 CG PHE 1139 107. .670 24. .280 132. .044 1. ,00 27. .20

ATOM 2040 CDl PHE 1139 107. .893 25, .630 132, .299 1. ,00 25. .89

ATOM 2041 CD2 PHE 1139 108. .690 23. .518 131. .483 1. ,00 27. .89

ATOM 2042 CEl PHE 1139 109. .101 26. .212 132. ,011 1. .00 26. .60

ATOM 2043 CE2 PHE 1139 .109. .913 24, .088 131. ,184 1, ,00 28. .43

ATOM 2044 CZ PHE 1139 110, .123 25, .443 131. ,450 1, ,00 28. .31

ATOM 2045 C PHE 1139 104, .094 23, .003 131, .624 1, .00 25, .43

ATOM 2046 0 PHE 1139 103, .171 23. ,315 132. ,368 1, ,00 24. .30

ATOM 2047 N LEU 1140 104, ,166 21, ,832 131. .009 1, ,00 24. .47

ATOM 2048 CA LEU 1140 103. .123 20, .840 131. ,156 1, ,00 23. .19

ATOM 2049 CB LEU 1140 102. .554 20, .497 129. .783 1. ,00 22, .43

ATOM 2050 CG LEU 1140 101. .042 20, .378 129. .638 1, .00 22, .70

ATOM 2051 CDl LEU 1140 100, ,347 21, .532 130, .323 1, .00 22, .43

ATOM 2052 CD2 LEU 1140 100, .702 20, .368 128, .155 1, .00 23, .99

ATOM 2053 C LEU 1140 103. ,708 19, .609 131, .810 1, .00 23, .00

ATOM 2054 O LEU 1140 104. ,572 18. .943 131. .252 1, .00 24. ,30

ATOM 2055 N PRO 1141 103. ,263 19, .302 133. .027 1. ,00 22. .81

ATOM 2056 CD PRO 1141 102. ,349 20, .065 133. .894 1. .00 22, .88

ATOM 2057 CA PRO 1141 103. ,777 18, .126 133. ,721 1. .00 22, .66

ATOM 2058 CB PRO 1141 103. ,290 18, .344 135. ,151 1, .00 22. .42

ATOM 2059 CG PRO 1141 102. ,003 19, .050 134, ,960 1, .00 22. .65

ATOM 2060 C PRO 1141 103. ,237 16, .840 133, .103 1, .00 23. .04

ATOM 2061 O PRO 1141 102. .044 16, .719 132. .832 1, .00 21. .39

ATOM 2062 N MET 1142 104. .125 15, .881 132, .896 1, .00 24. .58

ATOM 2063 CA MET 1142 103. ,757 14. .606 132. .310 1. .00 26. .08

ATOM 2064 CB MET 1142 104. ,282 14, .537 130. .889 1. .00 24. .74

ATOM 2065 CG MET 1142 103. ,748 15, .661 130. .039 1, .00 23. .66

ATOM 2066 SD MET 1142 104. ,337 15, ,545 128, .375 1, .00 25. .16

ATOM 2067 CE MET 1142 103. .295 14, .240 127, .721 1, .00 24, .74

ATOM 2068 C MET 1142 104. .311 13, .457 133. .129 1, .00 27. .87

ATOM 2069 O MET 1142 105, ,429 13, .518 133. .635 1, .00 28, .66

ATOM 2070 N SER 1143 103. ,520 12, .401 133. .246 1, .00 30, .37

ATOM 2071 CA SER 1143 103. .892 11, .233 134. ,025 1, .00 31, .39

ATOM 2072 CB SER 1143 102. .731 10, .252 134. ,044 1. .00 32, .34 rt rt t- ro o r- (M (— vo r- vo cM T Oo in o oo r- i— co ro ro o m <Λ cM θ ιn ro m σ-ι vo ιn t— T T T ΓO ΓO H T H H r- oo r- ^. -< CM VD m _ ro ro co m cΛ oo o τ t- JS _ CΛ O OO CΛ VO Cn H tΛ in t— (Λ CM O ro H ro vo co ro cn co r- vo o H rO H H CM co m o o H •s o H r- r^ oo ro cD eΛ T in H oo ro oo r- oo o oo oo in o β S β cM CM O CM ro cO T CM t— cΛ o σi in in vD vo co ro cM CM ro o o cΛ r- r- t— co in ro ro CM CM CM H o o H o o en o cM in vo oo m vo t— σi cΛ oo eo t—

CΛ ro ro cn co co n n ro in in vo in in in in in in in in in in in in T T -T 'T 'T 'T T T T T T T ro •qⁱ T T T T T T i-iⁱ T r r r c oooooooooooooooooooooooooooooooooooooooooooooooooooooooo υ H oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

PM _{H H} H H H H H H H H H H H H H H H H H HH H H H H H H HH H H H H H H H H H H HH H H H H H HH H HH H H H H H

CM c<ΛΛ CCMM ccnn . t- n cM H cn ro cM r- cM θ t- o <Λ CM Vθ H r- ro ro t- H ro ιn ιn vo ro r- ιn H 'τ τ vD oo cM H r- o τ oo r- r- τ cM in rH oo m ro (Λ CΛ

CM r- o ∞ r- ι o3 vo ιn r- cM CM τ τ o cn ro oo cn H cΛ co ιn ^ vo cM in cM r- ^ ιn τ H α3 Cθ r r o vo c '<- co c cM ^ ιn cΛ ^ c- H CΛ CΛ in o o t- in co τ θ H θ CD θ H C r ro D C θ θ co c t- CM r ^ _'τ o o H vθ H c» ιn <Λ M c ^ ιn r- cΛ ^ α3 VD CΛ H co ^r ^^, r _'q< vo r- r- 00 rH rH T CO c .^ c ^,w ^ τ* ι τ r ro cM θ in ιn ^,τ τ _> ιn ι r- r- r- vo ro ∞ cD cn --^ι o o o H CM C ro ro ro ro ro ro ro ro cΛ CΛ cΛ (Λ cΛ cΛ CΛ CΛ <Λ σι eΛ cn eΛ CΛ cn en cΛ cn cn cΛ o o o o o o o o o o o o o o o o o o o cn o^*ι <Λ CΛ cΛ o o o o

H HH H H H HH H H H HH H HH H H H H H H H H H H H H H H H

H H r- o m r— ∞ iO H H CM cn CM θ i ιn r- en in D t- CΛ oo r- VO H

(ll o o _ ∞ (Iι o n rH r in ro oo oo T CO cΛ t— (χ> ro cM in r- CM in r- θ H o ro cΛ τ cΛ cΛ ro ιn vo eΛ o vD t— vo oo en T T O O vo oo o o vo o o T H vo oo in t— o τ ro τ t— o

^ ro ^ o (Λ ^^ O H ln c^ ol ^ o ^ (O Φ ιn w l H α) ln ω ^ co r-• ιrι π o ^ o π o1 m ln ω ιc (^ι H N to Φ oo fl (Jl H ιn H '|ι m ^ o _ ω ιo ^ ro H in r- co H o in o vo cM Cvi vo H oo ro T CΛ t- t- oi n in o r- t^ ro ro in m ro σi vo vo cM ^ ro r- H oo cM to o r- tη n vo i^ cM in in in vo oo r- vo H cΛ oo oo o o cM H O o cΛ CΛ o oo r— oo vD VD in t— vD r- in T rO T T Hr m T i T r cM ro H M rO T H CM 'sr '- H CM O O

OOOO O OOOO CΛ CΛ CΛ O O O O O O CΛ CΛ O CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ Cn Cn cΛ CΛ CΛ CΛ CΛ CΛ CΛ Cn Cn CΛ C ^Λ cΛ CΛ cΛ cΛ cΛ CΛ cn cn cn cn cΛ cn cn H H HH HH H HH

n n n ^ 'J 'ϊ 'ϊ 'r Ol Ol W JI Ol OI Ol lΛ O O O O O O O H H H ri H H H N N N N N I Ii n i ffl tl rl V ^ iJ β ^ V 'J V 'I' if 'il' il' in in τ -- ^,-- ^,-- ^,-a-^ι '<- ^,^ _'<^ '<- ^ τ ^ ^ τ ^ τ ιn ιn ι ι ιn ιn ιn ιn ιn ιn ιn cn ιn ιn ιn ιn ιn ιn ιn ιn ι ι ^

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H rH H H H H H H H H H H H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM <N CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM

-< ^ ^ ^ ^ ^ ^ H H h O O O O O O O J J J »H j J ! < «ι; θ O O O O O O OO (CiH! lpιϋi lc-ύ lo-ύ OϋI (ciύl ltf- lrt- lrt>; cϋ ttf ft O-i i-i ω ω [_i HH HH H3 H3 HH ω ω cd ω ω ω i-i ω PH θ, pιJ θH CH θ, cS rt^ rt; rt! rt! fiC r r^ CO o rt; rt! fiC rt: Σ aι _ CU Cu l_. CH CU > > > > > > > rt; rt: rt; aι C a_J C-, Cl C-ι CLι EH EH EH EH EH EH EH EH EH

CM H CM CM

CD fiC CQ Q CD a u tt a ft CQ CD fit D3 CD CD ft ca a ft CQ CD rt! CQ CD Q W Q ω tH _,

O CJ O Z CJ O O ouucnuuo zuzυυuυuo O O O CJ CJ O U J CJ o cj υ c cj c- o z cj uuuuυuuou o z J ro T in vo r- CO CΛ O H CM rr) -τ ιn _⁾ t- CO Cn θ H CM rθ ^ ιn VO r- OO CΛ O H CM CO -T in VO [— OO CΛ O H CM rθ '51' in vo r- oo cn o H CM rO 'j' in vo t- oo r i- - r i- - r i- - r ι- - r i- - t— I— ∞ CO ∞ CX3 C» a3 CXι C» CO CO CΛ CΛ CΛ CΛ CΛ CΛ Cn Cn Cn cΛ O O O O O O O O O O H H H H H Hr-ι ι^ r-ι ι-ι ι-ι v CMi iCM iCM>ι iCMΛi ιC.M iCM vCM iCM-j vC.M. O O O O O O O O O O O O O O O O O O O O O O O O O O O H H H H H H H H H H H H H H H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM C^

00 se

Σ o ΣΣΣΣΣΣΣΣΣΣ∑ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ o oΣΣ HoHoHoΣ EHoΣ EHoΣ EHoΣ EHoΣ HoΣ EHoΣ ΣΣΣΣΣΣ EHoΣ EHoΣ EHoEH EHoEHoHoEHoHoEHoEHoEHoEHoEHoHoEHoEHoEHoEHoHoEHoEHoHoEHoEHoEHoHoEHoEHoEHoEHoEHoEH EoHoH EoHoHoEHoEHoEHoHoEHoEHoHoEHoEHoH O ft f tt ft < ft < ft tt t < f ft ft f ft tt ft fZ t f ft t f ft t Λ ft f^ it

CCMM CCMM CCMM HH '-, T t— ro in co co ro ro ro oo o CΛ r- •-- H H H •=- vo in t— t— cΛ CM CM CM H cn cn cΛ cΛ o ooooooooooooo ooooooooooooo σi oo cM T in ro vo co cM H t— τ ro cΛ <Λ ιn ιn m «-' ro cM CM H T CΛ ro rO H o r- CM vD H CM CM T O in cM r- T H oo r- ro ro o ro ro cn T t- VO H CM 00 H H r- r- ro m co cM r- in in ^r cM r- Mⁱ vD CΛ oo ro r- H in r- r- vD m cM ro ro t- <Λ cn cM CM t— eΛ CM cn cM vo oo cM o m ιn oo ιn r- H CM o co ro t. ^■- r— r in vo m o r- co cM H in m vD . T o cM ^r T VD oo rO T t- OO rO CΛ H H OO VO r- CΛ OO H rO CM O '- in CO I- Cn VO rO CM H H H O H H I— CM CΛ in m VO r- r- in VD OO OO CΛ CM H CM rH rH CM H H O CM CM C CM rθ τ rθ H T rθ H ι-l in ro •<, r rθ CM rH CM in VD in VD VD VO Vθ m in 0O (Λ 0O CΛ 0O 0O t- CΛ O O O O O O O O O O O O O O o o o o o o o o o o o o o o o o O O O O O O O O O O O O O O O O O O O O O O O O O

T 00 O <^' ιrι ^ι (ι ιn ol lJl H ln n ^ c^ι ^ (Λ » ^ « Φ ffl M H CΛ o oo f ln N O Φ ^ cvι ιn Φ O lO H ^ N ^ O l r- H ^ (^,^ o o o

CM m T n ^ π ^ <f ιn ^ ^ ω ^ w co(o Λ O ( ιn ιn o m ^ r n H oo co ιn N Λ Φ <D co ( n Λ Ol ιn N H β fO oo ^ ^ ιΛ ^ o co H o ι o so T m T _ [\| C0 N H 00 H 0S W iη a « 00(r| [ N O in * H Φ (Jl H O N H t θ O O H (! r- <Jl« m θ l^,l in « lf| inVI) N O (0 N a in H irl τ ιn ιnvo ^ji vo vD vo ιn vo c "3< H H o CM O O O <Λ 00 t- ⁽Λ CΛ O O rH CM o o cΛ oo t— vo ιn ιn o r- vo r- cD in co ιn τ ro t— r- oo cΛ o o cM CM

•""P 1— T T T T T t ro ro r co ^r ^ji _*- '. T T ro ro ro ro ro n ro n ro ro ro ro ro ro ro ro ro ro ro rθ 'τ τ τ '31 o^ cn cΛ CM CM co co H r- H cn o ro ro r- cM O CM ro in o cM CM cΛ cn cM r- ro oo 'T CM H CM H O o in oo r- ^j r τ cM in m "3^, oo vo ro τ τ θ H τ r- co o τ ro vo >-ι^ι r- cΛ H oo H co m vD o oo cM r- r- r— cs cM T H oo cΛ eΛ oo oo co cM O αo ro oo m m cΛ r- co t— CM in t— t— T CΛ Γ- CO CO T O O CM ΓO CΛ vo T CM VO T ro -T H O t c in o c r- c i— cM oo oo cn co vo oo VD eΛ r— oo H ro rΛ T VD t— T CM CΛ vo cΛ H CM T OO H rO VO in t- CΛ t— H H t- H 0O C0 x oJ OT ω o _ oo co cn co cn cn

ιn ιn ln ιn ιrι ι ιrι ιn ιn ln ιn ιn Φ φ Φ r^• ^ ι-- ^ ^ ^ co _ ffl _ co ro ω m <J Ol CIl Ol <3\ ι^ι o m o o o o o o o o o H H H H H H in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in tn in in in in in in in vo vo vo v^

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN C^ cu C_ c_ cu α. α M C_ _, ι_c Q- i_ι p_ eH C_ α5 pi αH « CH o- PH (_; _H Pc; oH pH CH CH PH CH (-; x _: a _ _, _H _: _. w ω w ω ω pH CH p5 ι_; Λ

E^H E^H EH E^H E^H EH EH E^H E^H EH H EH EH EH H EH H EH EH CO CO C C_ CO C C_ CU CM CM CU CM PH CD O U O O CD CD U HH HH HH CM CM CO H H CM CO CM H CM H CM cα cD Q ω ω α ω si si aπ rtj co D cD SC Q Q ΛI CQ CD < n υ Q ω U < n uα u «ι < co CD o ω

CJ CJ O CJ O CJ Z CJ CJ CJ U O Z CJ CJ O O U O Z CJ CJ O O O Z CJ O O U CJ O Z U U U CJ O O O O Z O CJ U CJ U Z CJ O Z O U CJ CO CJ N m ^ H H H

Table 6

ATOM 2185 C MET 2161 83, ,650 39. ,484 109. .569 1. 00 47. 71

ATOM 2186 O MET 2161 83, ,321 40. ,305 110. ,422 1. ,00 46. ,77

ATOM 2187 N GLU 2162 82, ,789 38. ,707 108. ,928 1. ,00 46. ,49

ATOM 2188 CA GLU 2162 81. ,362 38. ,763 109. ,154 1. ,00 46. ,30

ATOM 2189 CB GLU 2162 80, ,680 37, .832 108. ,164 1. ,00 48. ,00

ATOM 2190 CG GLU 2162 79. ,214 38, ,119 107. ,992 1. ,00 51. ,96

ATOM 2191 CD GLU 2162 78. ,966 39. .454 107. ,321 1. ,00 54. .10

ATOM 2192 OEl GLU 2162 79. .457 40, .479 107. ,846 1. .00 55. .94

ATOM 2193 OE2 GLU 2162 78, .284 39. .475 106, .268 1. .00 56. .14

ATOM 2194 C GLU 2162 80, .944 38, .398 110. .582 1. .00 45. .40

ATOM 2195 O GLU 2162 80, .121 39. .081 111. .190 1, ,00 45. .60

ATOM 2196 N LYS 2163 81. .506 37, .319 111. .118 1, ,00 44. .38

ATOM 2197 CA LYS 2163 81. .153 36. .896 112. ,468 1. .00 42. .97

ATOM 2198 CB LYS 2163 81, .607 35. .459 112. ,747 1. .00 43. .63

ATOM 2199 CG LYS 2163 81. .071 34. .923 114. ,078 1. .00 43. .85

ATOM 2200 CD LYS 2163 81, ,675 33, .576 114. ,468 1. .00 44. .67

ATOM 2201 CE LYS 2163 83. ,171 33, ,672 114. ,728 1. .00 44. ,08

ATOM 2202 NZ LYS 2163 83, .546 34, .722 115. ,741 1. ,00 45, ,08

ATOM 2203 C LYS 2163 81, .759 37, .817 113. .511 1. .00 42. ,14

ATOM 2204 O LYS 2163 82, .889 37. .607 113. .956 1. ,00 41. ,65

ATOM 2205 N LYS 2164 80, .993 38. .830 113. .911 1, ,00 41. ,38

ATOM 2206 CA LYS 2164 81. .459 39, .791 114, .907 1, .00 40. ,83

ATOM 2207 CB LYS 2164 80. .715 41, .121 114. .766 1, .00 42, ,68

ATOM 2208 CG LYS 2164 81, .076 41, .904 113, .502 1, .00 45, .26

ATOM 2209 CD LYS 2164 81, .126 43, .406 113. .792 1, .00 47. .67

ATOM 2210 CE LYS 2164 81. .036 44, .253 112. .519 1. .00 47, .25

ATOM 2211 NZ LYS 2164 79, ,682 44, .252 111. ,886 1. ,00 48. ,33

ATOM 2212 C LYS 2164 81. ,372 39. .314 116. ,354 1, ,00 39, ,23

ATOM 2213 O LYS 2164 82. .065 39, .846 117. .222 1. .00 39. .43

ATOM 2214 N LEU 2165 80, .522 38, .324 116. .619 1, ,00 36, .91

ATOM 2215 CA LEU 2165 80, ,391 37. .790 117. .969 1. .00 33, ,81

ATOM 2216 CB LEU 2165 78, .939 37, .752 118. .420 1, .00 32. .68

ATOM 2217 CG LEU 2165 78, .777 36. .988 119, .740 1, .00 30. .79

ATOM 2218 CDl LEU 2165 79, .495 37. .744 120, .834 1, .00 29, .86

ATOM 2219 CD2 LEU 2165 77, .310 36. .829 120, .098 1. .00 29. .83

ATOM 2220 C LEU 2165 80. .925 36. .382 118, .059 1, .00 32. .95

ATOM 2221 O LEU 2165 80. .433 35. .485 117, .381 1. .00 31. .95

ATOM 2222 N HIS 2166 81. .929 36. .184 118, .902 1, .00 32. .94

ATOM 2223 CA HIS 2166 82, .482 34, .863 119, .074 1, .00 33. .18

ATOM 2224 CB HIS 2166 83, .967 34. .837 118, .748 1, .00 38. .15

ATOM 2225 CG HIS 2166 84. .471 33. .461 118, .447 1, .00 44. .40

ATOM 2226 CD2 HIS 2166 83. .813 32. .337 118, .067 1, ,00 45. .92

ATOM 2227 ND1 HIS 2166 85. ,801 33. .110 118, .548 1, .00 47. .16

ATOM 2228 CEl HIS 2166 85. .940 31, .829 118, .249 1, .00 48, .42

ATOM 2229 NE2 HIS 2166 84. .748 31, .337 117, ,953 1, .00 47. .24

ATOM 2230 C HIS 2166 82. .249 34, .367 120, .487 1, .00 30, .67

ATOM 2231 O HIS 2166 82, ,909 34, .791 121, .428 1. .00 29, .79

ATOM 2232 N ALA 2167 81, .281 33, .469 120. .625 1, .00 29, .14

ATOM 2233 CA ALA 2167 80, .946 32, .898 121, .914 1, .00 27, .52

ATOM 2234 CB ALA 2167 79, .423 32 .832 122, .095 1 .00 26. .36

ATOM 2235 C ALA 2167 81, .553 31 .511 121, .912 1 .00 26. .95

ATOM 2236 O ALA 2167 81. .368 30 .742 120, .965 1 .00 26, .26

ATOM 2237 N VAL 2168 82, .294 31 .206 122, .971 1 .00 25. .92

ATOM 2238 CA VAL 2168 82, .954 29 .921 123, .100 1 .00 24. .85

ATOM 2239 CB VAL 2168 84, .389 30, .007 122, .556 1. .00 25. .27

ATOM 2240 CGI VAL 2168 84, .377 30, .434 121, .101 1, .00 25. .08 rt O t- ro H t- oo cn m τ H ro cM CΛ τ r- ιn H r- vo oo cΛ ro o r- ιn t— VD ΓO CM O T Γ- VO CM T H r- T o H VO Λ CO CM r- H t— CM OO ^T O O CΛ CO CM H T rs CM ro cn t- cn cM r- r- co ^i m ro '-. co t— O VO H CM <Λ OO CΛ O CO in VD T VD rθ rθ ^' H in CΛ ro ro T CM ^P OO CM m rO CM CM r- CM O O OO rO H CΛ CΛ

© © '» 1_f ^ι^ι o^ ( n H N ι^ (^ι ^ ιn ιΛ ιn ιo » » Φ (o <Λ tD Ol H N f « ^ 01 m ιl^ α) _ Λ «) «l ^ lll o o H O O H H ι ιo ra H •f in ^•* CO •<- T CM H

CΛ CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C CM rO rO rO ro n Cl CM CM CM CM CM CM CM CM CM ro r^ T ro ro ro ro ro ro

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H υ OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO M H H H H H H H o cΛ in in in ro t- H H cn ro cn o H co cn cM in cD in oo 'T T T t— H ∞ cn cn vo ro ro i— H O i r- H H CM -T t— vo cM vo ro o o cM vo H t- oo oo cn vD

(Ji in io o oi σi oi N m o ^ o ^ ω N ^ o ω o ^ o a n s oi aj in i ^ oi o o o r H rt fl N ω m ai m ^ m H N in H in io ϊi ri N W j) - ( ιΛ « ra o H o ^ _ ^ aι ι ω ^ . ^ (π o3 eo N'H ^ o ιrι o w (O H ^ o ιn « oa ^tl (sι ^ (Jl o ιn o v r- al (X) ιn ιo τι' ιn 0 1» H ^t^ι n •» co *τ ιn τ ro co vo *τ co tn r- oo cΛ t— i— r— r- t- in in in ro ro H H cn oo ro ro cM H O H CΛ O CΛ o cn o cΛ H eΛ eΛ t— vo m τ ro cM H Vo m co in vo r—

I CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H H CM CM CM CM CM CM H CM H CM H CM H CM H H H H H H

HHHHHHHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHH

VO CM CM VD O CM H CΛ CΛ r- VD 00 T O H co r— in vo vo T in vo T VO T VO r— o c _n• o _oJ iH— ι ιr-~ vo cM T T CΛ ro ro in cΛ VD m H oo T oo o c— m oo T '-' vo CΛ CΛ H OO in rO T OO H T T 00 o t— o vo r- oo ιn ιn vo cn τ cM ro vD in cM VD CM ^>^ι r- r- ιn o m c _M . «- . o vo r- m oo oo t- r- eΛ oo m O T t— ιn o τ

CΛ T ΓO H O Γ- CM CO O H T T in ro o CM OO H O CM H CM OO VO H O CM rO CΛ CΛ CM ^l' CM OO 'Cr H H CM T OO CM O t— r- CO CM OO OO CO ^l' O H r en o cn o o3 r- r- vo ιn c» c» c» c» ∞ t— vo oo t— in t- r- r- r- r- vo vD vo t— ∞ cn r- eo co t— c cn en π cM r^ rO CM rO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CO CO rO rO rO r^ oo ω o H l H m n ^ ^ o ω ^ι ιη eo ^ n ^■» lD oo ιo M ^ ^O N » O N (η w <s o ^ <l^| O ^ O ln ιn l N ^ H ^ ω N O ιJι m oo H (^ι o ^ι o r o^ lΛ ιn 'ϊ (ι 'J O N β H lD ( l N ι (^rι ιn ln a n H n o m » ^ ln N (^ H ^ ^ H to ιΛ '^' ()l !» H H ra H N O (J^ M n r- ^ ιD ^ ^D _ i H O n N O t o in co ^β H fl in in N ^ oi m o H iJi o W ri N O CΛ O Φ ω ω in ^ m oi o n in m i m tπ m ^ ro ai ^ N m oo ω N in N N ιn ( ( M iη m fl r ι» ιπ ι ω ^ a) m Λ θ H iB m ^ ^ a aι o o H N iη o ft H θ Φ (o co H ( θ H (\ M i») '» fl θ iιi H θ θ _

CO CD CO CD C» CXI CX) ∞ CD CD CD CO C» C» C» CO CO CD Cn cΛ c» CD CO 00 ∞ cx> CX) 00 Cn cn C^

ca ∞ oo cn cn cn cΛ eΛ cn cn o o o o o H H H H H CM CM CM CM CM CM CM CM CM Co ro ro ro co ro rO 'T T T 'T 'T ^ T in in in in

Φ Φ Φ Φ Φ Φ Φ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ r. r- r-^• r-• ^ t-• ^ ^

H H H H H H H rH H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

Hπ J HH O O O O O O O fiiH fiζ fiC irtJ rtl rtJ fi rf tn n n oi oi ω w t ra iH βi iK iH iH f- ciJ J iH Hi hH J Hi J n n c co co co co co co ω ω ω ω

«; fiC fiC CH « PH C_ l_; _: a; HH HH HH HH HH HH ₁-l t; β; rt! rt; ^ x x x x x x x x x a x x x x x x ft ft ft ft ft fi x x x -* ?H ?-* ^ ~* ?-* ζ∑l CC EC nc

> > >c, o,o, (. a₁ ιiι aιr fi, HH HH H^ H^ HH HH Hj HH HH EH EH EH EH EH EH EH > > > > > > HH HHHH HH^H Hq HH HP lH HH HH l-l HH HH HH

CM H CM H CM CD D ft CQ CD CQ tt CQ a w si f m CD rt! CQ CD O rt! oo CD a r_) si fit! CQ CD O J O O CJ J J O O UϋUOZ U J J o z c o cj o tj z o o O O O O O O u o υ u u o z υ u u o o z o o z υ o CJ

H c^ ι ^ ιn ^ oa ol O H M n ¹» ln Φ ^ ω al O H N n ^ ιn ω ^ oo m o H ^{( ( ■}» ιn ^o ^ ^^ι <Jl o H ^ι n <^ ln ιcl ^ oo m o H N (o ^ ιn - ^ ^ ^ ^ ^ ^ ^ ^ ^I ιn ln ιn l ιn ιn Λ ιn ιn ιn Φ Φ Φ Φ Φ Φ ^ ^ ^ ^ ^ ^ ^ ^ a) „ co ω o^ to eo ω ω oo _ <Jl O <Λ σl m <l

CM CM l CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CN CM CM CN CM CM CM CM CM CM CM CM CM C CN CM CM CM CM CM CM CM CM C^

00 rH rH Σ ΣΣ oΣoΣoΣoΣoΣoΣoΣoΣoΣoΣoΣ o ooΣooΣoΣ ooΣΣoΣoΣooΣΣoΣΣ∑Σ∑∑∑ΣΣ∑ΣΣΣ∑ΣΣ∑∑ΣΣ∑∑ΣΣ∑ΣΣΣΣΣΣΣ∑

EH EH EH H EH EH EH EH H H EH H H H EH EH EH EH EH EH H H EHoEHoEHoHoHoEHoEHoEHoEHoEHoHoHoHoEHoEHoEHoEHoEHoHoEHoHoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEH o et f f f ft t ft tt ft t f t t < ft ft t ft ft t f f tii ft t f^

VO H co r- H H «^ι '. oo oo

CM (— OO CD CO OO O CΛ t— O CO ιf^τOι θCΛ rHH rHH uCn-ι cooθ uinι rϊ CCM CCM _'T rH _C i_' e_> --» v_ _₃ _j uι \_i V_'_Oι ^i 00 ^* O C ιn r00^ Ln CM H r— O CO ^ ^ CO H OO r— VO O T ιn cn τ o r- H r— CΛ vo oo en ^t- c^Ml ΦVD (r^o ^r- ΦvD HH NCM mro ιinn ooo9 H (ι H ω o _ 01 H cvl r ln ^ ω <)l n Φ ιΛ α) (») U1 σl t H ln ι^,) Φ oo Λ N H H N crι

H t— 1-I OO T rO in θ CΛ CΛ VD O CΛ CM CM H VD (Λ VO "-»ι r- CΛ [-- CO ^r VD r- r- (O ^ OO OO t— O CM i-H CO O H H in T H O OO CM O VD I— H CO <Λ CM VO CO «- r- co oo cΛ cΛ T T ro H O O O CΛ CΛ O CΛ 0000 O t— r- vo m vo in m i -' in vo 's-t '-' o cM. H H CM CM H H H H O O OO r- OO O CΛ H H H CM

H H H O O H O O O H O O O O O O O O O O O O O O O O O O O O O O O O O CΛ CΛ CΛ O CΛ o o o o

<» H H io ιn N H iη N oi ιn H iJi ' i<) <f in <)i H iιι ιιι ι^,) o r- r- r0 CM in m '-' in H in m rO OO H m CM VO OO T O r- T T m cn cM VD CM vo cn r- cM t— H Vo o m cM CM oo σi oo ro vo ro cM t- I— r- r- r- t- r- r- OO 00 CΛ 00 O O O H 00 H CM CM C0 H CM r ro ro r r r ro ro τ H H θ θ^ ιn cM vo cΛ H CM CM co cxi H CΛ θ iΛ co α3 CM in r- ιn H H ro ro o (X3 CM cΛ 'τ ro co ro ro H ro vo H r- H θ oo vo r- ro m co H oo r- o c -Λ t -- c —Λ r ^■- r- o —o ^■vD- m - m - -r- CM -vb- H Γ roO OrøO VvoO Ir—- vvDD vvoo imn mm rrOO ''T-i' CCMM HH rroo rr-- VvDΩ iinn rr—- vvoo rroo oo co τ ιιnn c CMM θ _ vo m vo r- oo τ vo vD τ H r- ro oo ^r oo vD o σι VD o r- τ τ vo σι r- cΛ r- 000 Cn O VO T CM OO in CM CM CΛ H VO r- VD OO OO VD r- H ro co in ro T ro T σi r- CM VO ιn vo oo o oo H t- oo r- CΛ r- OO t— H CM O H H O H CΛ O H Cn CM H CM rθ H O CM H CM CM H CM H r r rθ 'T in VO in VO VO VD VO in r- r- OO CΛ <Λ O H O O O O H CM CM CO oo oo oo rø oo cn cn cn cn cn cn cn co cn cn cD CΛ cΛ CΛ cΛ cΛ cn cΛ cΛ cΛ cΛ CΛ cΛ CΛ cn eΛ cn cn cn cn cn cΛ cΛ cΛ cΛ cΛ CΛ cn cn cΛ cn o o o o

⁽o io - o o ^ ^ ^ ^ ^ ^ oo ra co m m o σi oi oi ci oi m o o o o o o H H H H H H N N M N i n m i iη to i v v 'f ii' ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ r^» ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ o _ ω oo oo ω _ _ co _ _ ω co oo ω α) oo ω ω tD oo _ _ _ _ _

H H H H H H H H H H H H rH H H H H H H H H rH H H H H H H H H H H H H H H H H H H rH H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

[-1 U- C_ I_I _- C_ I-1 CO CO CO W CO CO CO CO W CO CO W CO CO CO O O O O O O O CH OH CH CH PH O C- PH CH ^H I_; (_; CH P- 0H C- PH O O O O x x x x x x x cύ cύ oύ Λ ύ Λ oi ω ω tύ ω ω ύ i ω a ω ω iύ rΑ ri ri rH - x x x x x x x tύ tύ βi ζύ c cύ O^j c c oi ai Hq H^ H^ H^ Hj .j H^ H^ iJ o υ υ υ υ υ Λ ai a' aj aj co co co co co c c o o cD O O EH EH EH EH EH EH EH C-I C-I CH OJ

r- ro O CM ΓO O Γ- Γ- CΛ O o cΛ ro in ro vo oo o o vo in cΛ T cs oo tΛ T Oo in t— C- tn θ H VD cn vo H CM CM oo θ ιn cΛ oo

H H M O O o r' ιn H H l^l to ^ ^ ^ ιo ι/l r• ^ lIl -

CΛ 3 τ -* '-- ^,τ τ τ oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H υ oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

rO H T CM r— 0O CM 0O CM t— C .. c_n. ^ -ⁱ o _ v_o .cM. 's ,r σ _\. ιn cM CD CM rH r- cM co τ H H CD ιn ^ vD r ro ^i' <Λ cθ H CM CΛ r- H r- oo H H in ιn r- ιn r- r- ro oo VD H H VO CO m σi l— H N ω o O N CM l 0»0 o o() ^ (^ι n Φ n ^ N ^ ol o o^ ^ ^ Φ v ln <Λ ln Φ H O^ (Λ Φ M O^ m lrl r'l co ^ ln tv! ( m ^D o o co ι^l 0O 0O "- <Λ 0O H t- 0O CM [— ^• σ — ^■ in- ^■ vo- - r- m - ^■ vo- o — cΛ H τ ro vo r— o σi oo in H ro ro vo o vo t— CM VO T I— o cM CN ro r- o σi m oo vo cΛ r- H CΛ co co cM cM CM ro cM rθ 'q' τ r '3' CM in ιn m τ vo co ιn co r- cΛ o H H O H O H CM CM CM CM rO T T '- CD VO VO VO r- OO CΛ OO VD oo oo t— co m t- vo in T

O OOO OOOO O OOOOOOOOOO O H H H H H H H H H H H H H H H H H H H H H H H H

H H H H H H H H H H H H HH H H HH H H H H H H H H H H H H H H H H H H H H H H H H H H

CM CM co θ H H CM H oo ιn τ ro cΛ r- H oo vo ro cM t— t- oo in cM in cM cn o ro cΛ H ∞ rη vo cM in co co vD ro o cΛ O co vo ro cM in oo oo cM CM Co cΛ H in τr o ιn H CΛ t— o ro cM θ oo ro vo vo cM H VD τ r- H θ τ r- vD CM co r- cM τ ro ιn o θ ro ιn © CΛ τjι r- o ιn τ <Λ o θ H oo oo ιn eΛ CM θ H vo m ro ^ « ^ N H H (Il H o r• ^ <r ln o ri ri (!l f) H O v '^^ι 'ι^| o ttι n H lo oι m N H ^D ^Iι r- o ^ι ιn ^ O f10 (^,l ^ » n tIl o ^ι^ι o^ ιιl r• ol H _ co o o cΛ oo r- m ιn τ ιn co cn oo oo cΛ CΛ r- oo r- cΛ oo cΛ o o r- oo vo vo τ ro cM τ vo in co vo oo cn o H CM H co vD vo in m ro ro rM H CM CM H ιn ι ιn 'T 'T 'T 'T 'T *T 'T 'T 'T '^^, '-^, '^t3^l '^* 'T T T 'T *T 'T in ιn τ τ '^^, τ τ 'T T T τ τ '- »^ '. τ ιn ιn ιn ιn ιn *- -- -τ -- '_ 'τ *- '<- *. '. '. r o (0 » H ^ι o ω m N ^ n ^ O N H <» n m ( ^o m ^ m lJl Ol ιo o ιn n ω (l\ ln o ιfi H W oo ^ « M ol ιo ιn ^o ιn H ' H W lo ^l) [D H •^^ι r o co vo in co ro T H cn cn 'T O VD VD in ro cM cn vo oo vo in oo cn H O o cn rO 'T r- in H in co o T r- σi cΛ vo in ro cM CM r- o ^ oo vo vo t- oo cM ro T i

O O O VD H CM r- CO r T VD 'T CO CM CO rO H CM VO CM VO CM CM ^ ^ rO VO ^ ^ H ^ '^ VO VO in CO O O t^ ∞ T CO VO CM CM H CΛ CΛ eΛ ∞ ιo ^l H N N n M H H H H (^l o ol (I^ (o o o o o o H O N (!l ιx) Λ m _ ^ lD oo ιIι ^ ^ m ^ ιo ω » ln Φ ln w ^ ^ ^•^ ^■n v (l ιo ι) (η H o o o o o o o o o o o o o ^ iΛ CΛ CΛ o o o o o o o cn cn cn cn cΛ CΛ CΛ cΛ CΛ cn cΛ cΛ CΛ cΛ cΛ CΛ cn cn cn cΛ cΛ cΛ cΛ CΛ cΛ cn cΛ cn cn cn cn cn

H H H H HH H HH HH H H H H H H H H H

¹^ ^ J ιn ιn ιn ιn ιn ι ^lΛ ιn ιn Φ Φ Φ a w Φ a ^ ^ ^ oo ^β _ co α⁾ ω _ ⁽D <Λ m m ⁽! m <Jl <Jι ⁽] Λ Ol Sι o o o o o o o o o o o

⁽O OO OO CD ∞ ∞ CO CO CO CO CO CD CO ∞ ∞ ∞ CD CD CO CD CO CD CO ∞ ∞ OO OO CO CO CO ∞

H H HrH H H HHH HH H H H H H HH H H H H H H H H HH H H H H HH H H H H H H H H H H HH HH H H H H H H H H

O Q O Z Z Z Z Z Z Z Z Z O O O O O O O CIH OH CH OH PH OH CH D D D D D D D D O O O O O O O a U HU H- HH H Cu Qπ C-i CU I-i C-i C-i

Cύ & Cύ rl rl l rl H^' rl rl rl rl lXl Cύ Ui lϊl Ul Cli ai X uι ω iύ a a fύ ω ^ ^"' Λ ^"' c ^■ϊi oi ι. cύ ρύ ^ ^ i cύ cύ cύ ύ a: oi cύ ύ Cύ a^j θ Cu O C5 ϋ O O CD O CJJ O C-. 0, C_ CL. I-ι C (-ι EH EH EH EH EH EH E^H Hl Hj Hj Hq H^ HH HH H^ fiC rtJ fi rtJ rtl rtl ^ ^ rtJ rtl rtl EH EH EH H EH EH EH EH EH H EH

H CM H CM H CM H CM CM CM ro H H CM CO tt cQ CD a ω ω Q ft CQ O ^ή, CQ CD O rt; cQ CD a Q rt; co CD Q ω I X X I I ooozυoυυozυo z o υ u u υ ozυuoυυo υ o υ υ o υ z o υ o o z z z υ o z u ft CυQ CυD υa uuJ uω ao ω S o z o o _ o

oΣ EH

r- ro o r— in ro σi cn vo i-i' T eo ιn H _3 in r- CM vo ιn cM ro cM r- co r- ri τ cn _'τ r- CM cn en cM CM CM CM Co cΛ CM in ιn vo cM vo in r- o oo r- vo cM O T cn ro o rs __ m m cΛ H i H >!3' r- o co cM co en cM r- o oo ro vo in in en cn cM O r- cΛ co in r- vo H in oo cM ro cM CM rH O 'a' O rH .-31 t— oo '. CM oo vo cM n cn r- co

© © r- cΛ o <Λ θ cn r- ιn r- CM H CM CM CM CM ro τ '-^ι '<r ιn vo oo co _^ o o <Λ σι o o o o o CM CM CN CM CO H O H CM H cn co 000 cn cn ro

CΛ δ CM CM ro cM ro cM CM CM CM ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ^ τ ro ro ^' T "_ T T ro 13¹ T T T ro ro *τ ro ro ro T

₀₀₀₀0000000000000000000000000000000000000000000000000000 00000000000000000000000000000000000000000000000000000000 υ PM HHHHH HHHHHHHH cΛHr-co^,>-rιncΛCMθocnrooooιncΛH CO CM CM VO

CM T VO H O CO t— CM O T in m VO CM OO OO cM rH r- vD

H oo ιn H ro en ro cM ro o τ rθ H CM θ r- in OO OO r- i σi o o H O O O rH CM rH c ti" ιn Φ W r^|i ιn <» <»

H H CM CM CM CM CM CM CM CM CM CM CM CM Cvl CM CM CM CM

H H rH H H H H

OO CO O H rO CD CΛ CM ro o in o H T co vo r- vo o cM ro o ro τ r- ro T CΛ ΓO OO Γ- H VO O

H H VD H OO H CM ^r T in π cM co cn vo vo cM

H W Φ a u lD ffι o ιn 9 l^,) N N O o m τ *τ τ τ τ τ *τ ιn T T n H flo o n ol

( ^ ιn ⁽ N l N N f H O H O H O H O H O O tD r- ^O ι ^ oo ^» oo o^ O H H ( N ιη (0 'l' ι oo m <J10 ll! ιtι ^o ^tι ιn ιn <l' ιn ^ v 7 r•

(Λ CΛ CΛ CΛ CΛ CΛ CΛ Cn cn CΛ eΛ Cn Cn cn cΛ CΛ CΛ CΛ Cn eΛ CO OO ∞ oO CO OO OO OO ∞ ∞ Cn cn cΛ CΛ W

o o o H H H H H H H H ^•^ι (^ι <^l N (\| N N N (^^ (^ M (^ on ιη ^n n n lJ ^ fl v lrι ιn lrι ln ιn ιo ^o ιo Φ lD lo ιβ ιo ιo ^ ^ ^ ^ ^ ^ ^ ^ r-• ^ cn cn cΛ cn cΛ cn cn cn cn cn cn cΛ eΛ eΛ cΛ cΛ cΛ cΛ cΛ cΛ cΛ cn cn cn cn cn cΛ cΛ cΛ cΛ cΛ cΛ cΛ cΛ σ^ cn cn cΛ CΛ cΛ cn cΛ cΛ

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

>H >H H < C0 C0 C0 C0 C0 D D D D D D D D D U W t-l t-1 t-l [-I C-l l-l C_l l-l

) O O m o H N ιη » ln « ^ ⁽. m o H ⁽! ⁽n ^ ln ω ^ co l^ O H ( » lΛ ^ (D ⁽Jι o H (^l ( fl ιn w eo () O H N ιη ^ lfl lD ^ eo ol O H ^ι (^,l ^■»

O H H H H H H H H H H CM CN CM CM CM CM CM CM CM CM CO r rO rO rO rO rO rO rO rO '-a' T ^ T T '. T *^

00 rH rH Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ rH O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O © EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH H EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH H H H EH EH EH H EH o ft fζ ft ft r ft fi f f t ft f f t ft t f ft t t t t f t

rt rt t- ro C- rO H OO CO CM CD CM CM O t— CO r- CM rO CM CO H CM '-' O H H CO O C OO OO OD in H in CO H I— CO t- CM m H o ro ro o m oo o oo cM CM t- co T CΛ in S r- H [— O T in H i t— ^r C M CO CD OO T C C H C H r- m C VO OO H r- H ^^H r- H eM r- 00 cn ro T r- r- (N oo H o en o o H co oo ^ cΛ CM in ro

© β § ιn τ ^. ιn vo oo cΛ oo τ ιn ro ro ro cM T m ro T H CΛ oo vD in ro ro ro ro r- r- vo vo m cM o cΛ O rH o r- in oo cn cn co cn r- cn o o m in in T T ro ro ro n ro ro ro ro ro n ro ro n ro ro r co ro ro c ro ro ro ro ro ro ro ro T "-

O O OO O O oooooooooooooooooooooooooo ooooooooooo ooooooooooooo υ H O OOO OO oooooooooooooooooooooooooo ooooooooooo ooooooooooooo

PM H HH H HH oo vo cΛ r- cn cn vD T ro H r- CD O τ r- O CD T H O in VD C» 00 V0 'T -* O VD 00 O V0 τ r0 CM in CM T C0 <Λ CΛ 00 T O VD O 00 H r0 T in r0 O O CΛ Cn O oo ro r- co H r- o oo ^ σi O^ in αa H T CM oo o co H H H Vo co cD cn o in r- CM ro cM cn T Cn in H rO H O o r r- vD T in oo H CΛ CΛ oo ro o cn H H m r- r- CM co t— co H H ^ CM CO O CD C r- H VO n oO r- in CM T T CΛ O lΛ O CΛ VO in CM OO CO H O r- VO Cn cO ^ O CM VD O H CM VD '^ O CO H 'T CM

T in in VD Vo r- VD r— <o r- in -r in in ro t— t— oo cn o ^ eΛ cn o H CΛ CΛ cn co co cn cn co o o cn o cΛ r- vo vo vD vo r- o Λ H H CM H CM ro cΛ cΛ CΛ oo

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rO CM CM CM rO rO CM CM CM CM CM CM CM CM rO n CM rO CM CM CM CM CM CM CM rO CM C^ CO rO ^

H H H H H H HH H HH H H H HH H H H H H H H H H H H HH HH H HH HH H HH HH HH H H H

» ^ ιo H ^ oo ffl (! O H fl H O H ( o (^ι ol ιn o '» ^ ιIι ^ O 'l^| O ιn ^ιι <^ι <J Oι ^ n ι m n Φ r- ι>l r• ^ (J1 lIι ^ o ιn ι N ^ M N (o ιβ o(βo oo t^— oO cNM θO cmo HH ^r- ccM^ι τ<^ cNM (cnΛ ιιnn τ•J HH θO ιion Λcn t^— oo orxo> rιηo ^r- oo ccΛιl ^r- cΛΛ Φco »cD θo oι»o ιιnn oωo c_M ιiΛn oo cιΛl ^τ-r> ιιn Λ<Λ ccoo HH iιnn nro cNM o ( W ιIl H O 'J ιη ^ o ω o (^ι ιl ^D Ol oo n H ln n cD Φ ^^ H <» (^ι Φ lo m ιn co H m ι! ^ m ω m ιfl O ^ Φ » w ^f 'f Φ ^■» H oo ιfl ιn Λ m T ro T vo r- oo σι CM CM H CM O CΛ O CΛ CO O O CM ro CM o o H H <M n ^ '3^, ιn ιn o o oo r- r- -> vo ιn τ τ rθ -⁾ vo ιn 'τ ro cM CM oo ro ro ro cM

^•». T T T '. '. '- rO T C rO T T T T T τ τ τ 'T '^ '^ '» 'T 'τ τ 'T 'τ r (^ fθ ro r m r r ro r r ro ro r o r r ro oo r- oo T in oO T vo ro vo m H i— τ vo ro r— T cn m cn

CO OO CΛ O O H H CM Cn σi O H O CM H O O rH H CM CM rH T O O cn r- t— r- t— oo co r- r- in t— _ ιn -> ιn τ τ ιn ro r- oo t— oo r- vo cn o oo t— σi o en cΛ CΛ O O O O O CΛ CΛ O O O O O O O O O O O O O O O CΛ CΛ CΛ CΛ CΛ CΛ CΛ eΛ CΛ cΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ Cn cn cn cn cn cn CΛ O CΛ eΛ cΛ O

Λ ffl iB π α^j ro o ro ω m m w m oi m ^ o o o o o o o o H H H H H H H H H H N N N N N N N N N N N cπ n fn in to n io iη v 'ϊ cΛ cn cΛ CΛ cΛ cn cn en cn cn cn cΛ cΛ cΛ cΛ en cn o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o

H H H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CN CM CM CM CM CM CM CM ω co co co co co co co co c

K H >H H H >H >H >H >H >H o _;o_,oC_oO_Ho«oP-oe_-W-WθMι_W*W><*W-i_'C><>*W-BHnMΩH(MBHnHBH(H«ιraHnMuaS r. u_Cr' _r);υr uuuuuuu[ιi[ι][ιiω[ιiωb]>< <

IlHH ^ J kl Hl lH J j Hl c t oι aι a, at Cij f f < < < t f x x x x x t ft t t tt t tt tt tt ft rH M oz m vo r- oo cn o H CM ro ^i' in vo t— oo σι θ H CM θ τ m vo r- oo cΛ θ H CM ro ^r ιn vD r- oo cΛ θ H CM C τ ιn vo r- co en o H cM rO T m co t— ∞ CΛ O

VD VO VD VO VO f- t— r- t— I— t- r- r- r- r- C0000000 00 C0 0000 00 00 cn CΛ CΛ CΛ <Λ Cn CΛ CΛ CΛ Cn o θ O O O O O O O O H H H H H H H H H H CM

^ ^ <-(ⁱ ^ ^ ^ ^ τ τ τ 'τ ^ τ τ 'τ τ τ τ ^,τ τ '^ τ '^ ^ τ ^ ^ ^ ^,^ ^ ^ 'T '-- τ τ ι ιn ιn ιn ιn ιn ι ιn ιn ιn ιn ιn ι^

CM CM CM CM CM CN CM CM CN CM CM CM CM CM CN CM CN CM CM CM CM CM CM CN CN CM CM CM CN CM C CM CM C^

00 rH rH rH ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ © O EHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEH o t fζ f rt f fi t t f f t ft t f ft t f ft f ft ft fti ft t t f t f^

rt r- ro vo o in H O vo σi ro H CM oo in vo T co σι ι vD ^τ H CM τ ro r- o cΛ oo ιn ro cM m ro o o <Λ oo m o t- cD cr> vD θ '- oo r- o σi o ro t- o vD H S m CM m t— m CO T CD CΛ O '. H m VD 'iai H rO H O CM m H m CM O rH VO OO CO H H m CO Cn T CO O CΛ H O CM _'-' H O r- cM CM o m m m vo cM t-

© © _ H H H O O CΛ O O σi O O CΛ OO OO CΛ OO H H CM CO t- cΛ θ H co ro cM CM CM H H CM CM ro rθ 'r tn oo H ro ro ιn τ ro ro cM co m vD r- m vo t— r- o

CΛ 3. T T T T T CO T T P τ τ ro ro ro ro ro τ τ τ τ ^ ^r ιn ιn ^ _'^ τ _'τ ^ τ τ _'τ ^ _'T '1-r τ τ τ ιn ιn L ιn τ τ τ τ τ τ τ τ τ τ 'T 'τ τ oooooooooooooooooooooooooooooooooooooooooooooooooooooooo υ oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

PM H H H H rH rH rH rH r— ιn r- vo H ro ιn ro o oo τ H θ ιn vo H. o_o_ o„o T . c.o. c.o_ .t— vo T CM cn r— r- t— en vo cM in vo H CM in in cn o H m r— o in H ro vD oo T r vo H cn m m CM CO CM CD H CM Cn oO T Λ m VO O m H OO CΛ OO O CΛ OO C <Λn - —τ Tτ v_o> iιnn tr—- oooo HH HH ccoo mιn e<Λn oooo ccMM rroo vvoD σσiι rroo oo ccoo oo H T'. rrO rrHH CcΛΛ HH min Oo T*τ OoOo HH rrOo OoOo

H O in vD CM H ro cΛ in t— <Λ H vo oo o cM cn cM r- r- ro in ro r- T O oo vD oo in CTi T co T CM co in cn o co in oo H ro o o cn ro ro co in r- oo o co i— VD t- vD in m τ cM CM CM ro τ H H ro rθ H CM θ cn cn oo r- vD in oo oo r- vo vD in t— ιn m τ ro cM ro cM T CO CM '- CM H CM H O CM ΓO T CVI ΓO '* VD CΛ

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rH H HHHHHHHHHHHHHHHHHH H H H H H H H H H H H H H H H O

HHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHH H rH H H H H H H H H H H H H H

O CΛ t— CO Oθ r- CM rθ in H O CΛ O CM θ m H τ r- rH [— Φ ci (o n ( rt M»i H

H oo co H CM CM ro cM r- CM in cn oo ro 'T OO oo O 'T CM T in - T - O — C -M^• C-M^{■ •}in- CΛ CΛ CM

O t- H OO O O CΛ r- t— CM OO H CΛ CO Cn cM VO O CM rH CD o r- H r- o vo en m ro

T ro in vo vo m vD VD t— CΛ CΛ CΛ H H ro vo r- vD vo T T ro cM i-i co vo t— oo cn o v- O r- oo r- vo m T T ro ro cM CM r- r- cn o ro ro co en ro co ro ro ro ro ro ro ro ro ro ro ^•-> •"-p ^i co ro oo co po ro ro ro ro ro co ro ro ro « τ ro ro ro ro ro ro ro ro ro ro ro ro ro ro τ T T 1- T ^•>* ro cM cn co cn H CM H CM Vo o in oo oo vo co cM in ro -T cn in cn H CM ro cΛ co cM CΛ o vo cM CM CM r- in o cM O r— co r- H o rθ H θ vθ H H '*_ ιn H CM Co cΛ t T VD T CD CM CM CM oo T in cn in vo t— vo vo o m vo cM vo ro in vo m in ro-ro m oo t— oo cM ^r oo vo o m cM VD oo cΛ CΛ vo cM vo ιn vo vo ro cΛ ιn rH oo τ cΛ i o <j ιn 'i" (D H θ fl 9 iιι ^ θ N in « iD N M v m o ω ιn Λ ι/i 9 Φ o a H ^ ιιi Φ ιn o a o ιιι o m α) N (π o iB iιi H (o Φ iD ω . i- r- o o cn cn oo oo cn co i— t— I— 00 00 00 00 00 CΛ O O O H H H H CΛ 00 O o en o O O O CM CM "- T T O H O H CM CM CM H H CM CM O O O σ-i O CΛ CΛ Cn cΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ σϊ O O O O O O O CΛ CΛ O o cn cn o o O O O O O O O O O O O O O O O O O O O O

^•» ^•. ln ln ln ιn Φ Φ Φ Φ ^ ^ ^ ^ r-^• ^ r^• -^• ω flo _ ω _ ι_ cD _ m <I ol ⁽J <⁾ σl o^ !Jι σι σι o o o o o o o o o o o O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O H H H H H H H H H H H CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM C CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ x x x tύ c & cύ ai ^Qil oζ tύ ctl cύ cύ cύ vi cn cn w cn tn ui tn tΛ rl J H H^ H^ HH H^ O O O O O CD O O O O CH _ C_ C_ H CH CH CH CH 0H C- rH r r r rl rH^' X X X X X X X X X X X X X X X X X X X X X fll f tt f£ & Cύ ύ ( θιi Cύ Cύ Ctι ai Cύ ai X X > > > > > > ft t tt ft ft t f tH E-> l-> t-' lH l-< tH £H fr< ϊH lH

H H CM CM H CM H CM H H CM CM et; fiC cQ CD ^Q ω Q cd i a < m U Q U N fiC CQ CD CD (ϋfflO DWNK a! fiU cQ CD α w Q ω si a-i υ o z υ υ o z υ o o o o o o υ oυo z υ υυυ υ z υ o z υ υ υ υ υ o z υ υυυ zυ z z o oz υυ υ o o υ o υo υ Co ^ ιn vo r- ∞ Λ θ H CN rη τ ιn _> r- ∞ cΛ θ H C r *-q' _ι vo r- cD - θ H CN r '^ CM CM CM C CM C C ro o ro ro r r r r ro ^ T '^ T T T 'T 'T '^ 'qi in in in in in in in in in in in in in in in in cn in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in m CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM Σo oΣΣoΣoΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ EHoΣΣ HoH H EH EHoEHoHoHoHoEHoEHoEHoHoEHoHoEHoEHoHoHoEHoEHoHoHoHoHoHoEHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoEH < < < < < f < ft tt < ft f f ft < f f < < f f f t ft < < < A

rt r- ro vo o •T vo ro o vo o t- o in oo in cM ro H O H oo cΛ cM H cn cΛ H CM vo eM r H H CM in ιn τ co ro vo cM CM o vD CM τ , T O t— CM rO OO H OO CM H H VO

JS ro in H oo M VD T T CM T r cΛ '-tⁱ oo vD r- vo in cM in o O T ^■.i ro r- ro co r- vo in o cΛ in σi o vD r- co oo ro T O αo in r- ro tn cN CM CO cΛ oo cΛ oo o o o o cΛ t— cn cn o rH oo ωoo oωo o_o ωoo oo cNM (ro -<o^^1ι ( r « 't^| (0 <_J ^, r- ^ ln ^ π1 <^^| H H o^ r^ (^ι N to ιn I ( '!l^| c^ι ^ ^ ^ •s-f •_ T CM H O T δ T T T ΓO ΓO ΓO ΓO T T T ro r ro ' T ^ ^ T ^ -T '^ ^ ^ c m t tη ro r m m c C C CM CM CM C C CM c CM CM CM C C C CM CM CM CM CM CM CM

H ooooooooooooooooooooooooooooooooooooooooo ooooooooooooooo υ ooooooooooooooooooooooooooooooooooooooooo ooooooooooooooo

PM

CM Co r- in ro oo '- CM t^- r- cM ∞ oo r- o vD CM oo vD iⁱ cM ro co r- ro H t- ro o «. o cM vo ιn o ro -fl' θ ιn vo o H vθ H CM oo oo o r- ιn o cΛ ro vo ιn cn r> C0 1Λ III ^ ^ H lO lt) [^ (! ^r H IO O [~ Φ H ffl lJ10 r') <V| CM O O «, <Λ CM CM [— oo vD VD ro co cM o oo cΛ VD vD T VO H oo oo ro ro co in cΛ vo ro ro r- ιn ro ιn oo vD oo τ r- o r- H CM VD cM CM rH H oo cΛ o cM in vo . ro ιn H H CΛ r- ιn r- ιn cn t- τ cM H τ o ro oo ro oo cn r- ro o cΛ ro <Λ o vo cM vo oo cn oo oo r- VD oo oo oo o t— CΛ CΛ CΛ O CΛ OO OO VO CO Γ— vo vo co r— H CM ro cM rH T T in vD r- t- cn o i— OO OO OO OO VD in O H O CM CM rO rO CM CM o o o o o O O O O H O O O O H O O O O ' O-^> 'O-^• 'O^ 'O-^, 'O-^> 'O-^, H H H CM H H H H H H H CM CM CM CM CM CM CM CM CM in to ω N ro ^ n Φ H fl N ^ O H m io t ^ ϊi ω o co Φ π fli N VO N N N ^ ro - O 'r in o oo in oi 'i' O O H ^ n in i ffi H i'i i/l iΛ fl ii' . ^ o ^l H Φ «1 ^ » o o ^ n ^ι m σι o1 (! lo <r (l H ιn H oo v ^ H (Il (Jl fl ln ιll H ln ιo (l1 ffι v o ( m o ιs Φ ^o ι ι^ι ^ ^ O H ιn ^•-• lrι _ ^ N « H H o o m » o v to Φ (Λ cn ^ to ^ ^ ^ ιn ιιι ιi) θi 9 θo ιn (D (θ H θ t o! ω _ (iι r- ιo ιn o co Φ 'i^, H r- N in oι iJi oo ι H H θ oι cn oo r— vo t— r- r- VD in ιn τ t— t— oo cn o H CM CM ro o H ro τ r cΛ cΛ oo t— vo vD co co r- r- oo oo oo eΛ vo vD in τ ro cM ro ro τ ^,. ro ro ^ι^, vo r- t— CM ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro T T T tΛ ro ro ro ro n ro n ro ro ro ro n ro ro ro ro n ro ro n r n ro ro ro ro ro ro ro o cM H T cn cM oo in cM CM CM T ro in cM cn r- oo en -T in o H O cn 'T r- oo vD O H T H cn ^p H H c cM in c t— vo co oo 'ϊ^ι r- H CΛ ro ιn cM oo ro cM CΛ r fO O N lJ^ co n ιn Φ H _ ιo ⁽\ H W ^ n Λ 03 ω _ ιn Φ U) N ^ H O H ^ ⁽I) o ιIι ιr) Φ lΛ ιη m ιη φ ^ ιo ιn ι o r- ^ι o H ln m Φ oo o ι H ι l ιn ι o co H m ^ _ ro - v Φ ^ ιn o o m ιo « ^ v ^ m u1 n H l N Φ m ^J (^l ι H H (Λ ιn v lO (Il o ιn ln ln 'l^| f') r- «f m H

O H H tι o ⁽Jl m ^ ^ _ ^ Φ ln » ^ ^ ^ Φ ^ ffl ^ α) ιn ^ ιn ιn fl Φ ^ ιn ιn ^ (O ιn fl ιn ^ ^n ιn Φ ιn Φ Φ ιn Φ ^ <ι^| l') ι^,l (ι H •^' o o o o o cn cn cn cn cn cn cn cn cn cΛ cn cn cn cn cn cΛ cΛ cn cΛ cΛ cΛ cΛ cΛ cΛ cΛ cΛ cΛ cΛ CΛ cn cn cΛ CΛ cΛ c^

o H H H H H CM CM CM cM CM CM CM co ro ro ro ro ro ro ro ro ro ro ro ro ro τ τ τ 'T 'W '1- ιn Ln ιn ιn ιn ιn ιn ιn vD v^

H H HH H H H H H H H H HH H H H H H H H HH H HH H HHH H H H H H H HH H HH HHH H H HHH HH HHHHH

rt: _ Pπ^' o- i_; a. ι£ _ u _ c_ aι H H _ _ ύ C^ H3 rE « a κ « ffi κ cH « _ *-H CH & c_ c_ H, CM Q^ fiC EH EH EH EH EH EH EH EH EH EH EH EH H EH H EH EH EH EH EH EH C C W C CO CO H H H H H H H H H H H H H I H ∑ ∑ ∑ ∑ ∑ ∑ ∑

H CM CM CM ro H H ro CM CM rH H CM H H ft ffl ft CQ CD O ft Q O Q w ω Q ti) SI SI 33 tt m CD fiC CQ O CD Q ft CQ CD O Q tt PQ CD a ω o z o o υ o O O O o υ o υ υ o o z υ υ υ o o O O o o z o υ o o υ υ o z o o o υ υ o o z o o υ to o o

ΣoΣoΣooΣoΣoΣΣoΣooΣoΣΣooΣΣoΣooΣ∑oΣooΣoΣΣooΣΣooΣoΣoΣ ΣoΣ∑ΣΣΣΣΣΣ∑ΣΣΣΣΣ EHoΣ EHoΣ EHoEH EHoEH EoHoEHoHoEHoEHoEHoEH EoHoEHoEHoEHoEHo∑∑ΣΣΣΣΣΣΣΣΣΣΣΣ

EH H H EH EH EH EH EH H EH EH H EH H EH H H EH H H H EH H H EHoEHoEHoEHoEHoEHoEHoEHoHoHoHoHoEHoEH o ft tt ft ft ft ft tt ft ft ft ft ft ft ft ft tt ft tt ft ft ft ft ft f$ ft ft ft ft ft ft ft ft ft f^

t- ro o o cΛ in cM in ro ro o ro oo in c_M ro t- T cn in cM t- cΛ vo i— en <s o CM o o oo ro o cΛ oo T r- oo vo oo in r- ^•>- in o in oo o o cΛ ^r in o in cM O r-

•Si H H in H H -s-r cM VO in tn in in t— o cn c oo T CM O H cn _'oi eomo r- c_M Vo ro cn vo in o cM T-i ro oo H CM CΛ o r- H H co oo T O 'a' -sr o t-

© o 3 T n T T in m in in T in i- O CM H CM CO H H in i¹ ιn ^^, «. ιn ιn ιn co cD c- ιn vD r- r- oo cΛ O H oo cΛ oo r- cΛ cΛ o cn t— r- t— cn o H T in

CM CM CM CM CM CM CM CM CM CM CM H CM CM CM CM CCMM CCMM CCMM CCMM CM CM CM CM CM CM CM CM CM CM rO rO CM CM CM CM CM CM rO CM CM CM CM CM rO rO rO rO

H oo oooooooooooooooooooooooooooo U ooooooooooooooooo ooooooooooooooooooooo O O O OOOOOO O OO OOO OO OOO OO O O O O O O OO O O OO O OO OO OOO OO

PM H H H H H o ^ r- in o ro in H t- oo o vo σi ^j' O O in cΛ oo in T VD VD r- ^ r H '- t- ro H CΛ H H c co <Λ rθ H CM co r— cΛ C VD CM ro r cΛ in r cΛ θ H t- o in cΛ oo cn o cn t— ^ ^ji vo c r in O '- in ro r r in oo D ^iⁱ r- CM r- H t— oo cM oo r- oo ιn oo o vD in cM rH co τ τ r- r— ci σi co N β f f oo O cM CM - r- -> _> m o co cM in ιn ιn H H '- cn co vo τ H '"3< (Λ H τ ro m ro vo oo cM in cΛ cn τ <n o o r- oo vo τ co cM ^^, o cM rH Cθ ιn cM Vθ vo o cM ro

N l n n (! H N ln ιrι ιn Φ ^ ffl _ - ω ιn ^ ιn αι oo co o H H H O Λ H (v! H N N H O M (! N H o o Λ ω ^ _ „ co ^ Φ ω _ _ ιΛ o rM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM ro ro ro ro n cM ro n ro ro ro ro ro ro n

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

O I— T H 00 H H ro ro cM H T CΛ in in r- in o cM CΛ H ιn τ ιn o oo vo o r- r- co cn co o H oo cM r- co o in r- T t—

CM CM T T O T H t— o vo o o ιn τ τ ro ro r- CΛ T O OO VO OO O l' CM '. rO O CM VO eΛ fO CM CD H VD OO OO H o ro r- oo σi VD VD in oo t— ro t- cn t- T CM CM H Cn rO in H VD VD OO T t— m vθ Mⁱ vo m τ o m oo co co r- cn vD cM co cM τ vθ '_ cn cM ro t— in H CΛ co ro cΛ o in ro cn vo in

H H O Λ ffl » » O H (Λ OO I» ^ O O O H N N H H O N N N H ( IO '» I « ^ ^ n Φ h » ^ Φ Cθ m Φ Φ Φ ^ ffl _ <D eθ β lβ Φ r- ro ro ro cM CM CM CM ro ro cM CM CM CM Co ro co r ro ro ro ro ro ro ro ro ro ro n ro ro ro ro ro c

T Co co in H oo in cn oo ro ro o cM co τ ιn c» CM τ τ ro o vo cM c_ι *>- co θ H CM o ro τ vo o ιn H CΛ co ιn τ ro r- ιn cΛ θ vo cΛ cM Vθ H ro o cM θ cn r

VO r— CΛ OO in O CΛ O CΛ H O '- in r— H T OO VO T H C e H O cn cM r- vo cM C Co rO T VO cM in cΛ t— o o en ro r— cn oo ro ro vo cn CΛ CM CM VD CM in VO in in t— CM T r- VD CM CO OO O cn iO O in rO r- CM CΛ VO O O CO O CO O VO IΛ OO H r- OO VO T CM O in cΛ m m T vo vD in r- T T co cM ro ro cM CM H O ⁽Λ o oo cn eΛ cΛ c» eΛ θ θ c- ∞ vD vD vD ιn ιn co vo r- oo θ H θo cΛ oo cΛ eΛ θ H H r- t- vo ιn τ τ cM H σϊ CTt σ'i σ σ^,ι <Λ eΛ CΛ <Λ CΛ eΛ CΛ CΛ CΛ CΛ CΛ eΛ m m ω ω ω ω ω oo cn o ω ω ω co co co o oo ω o-i oo σi cri co co co oo o -i oi σi co co ω ω ω ω ω ix)

^ 0 ⁽D 01 IB I» 0S 00 0 ⁽Λ 0i m 01 ⁽⁾l ⁽rι O O O O O O O ri ri H H H H H N N N N N N N m n ⁽ n ii n v « « fl '» 'r * 'r in i⁽) in in i⁽) in H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CN CM CM CN CN CM CN CN CM CM CM CM CM eM CM CM CM CM CM CM CM CM CM CM W CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM M CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

H pH θj θι CH aι C-ι C_ o- DH Cc; o- Q_ c_ o- ι-J J HI HI H J J J J J J O O O O O O O I- - ω co co co co co co co co ω ω ω ω ω ω fiti ft A ft ft A ft A A ft ft A A A „& ι, (- oi (- (. oi ω ω w (*ι w w n n ω n w n oι ω >ι ><

∑ A A A A A A A A co co co co co co > > >>>>>>>>>>>> CM Oi Oi CH ai Qj Cu c co c c co c rtl rtl rtl rtl rtJ rtl rti ^ HH iH HH iH i-H HH

H CM H CM H CM ft CQ CD a a fit; CQ CD A CQ CD O fiC C^Q O CD Q fit! CQ CD A CO C CD a ω o z O O O O O O o z o υ o o o O O O O O O O O O O O υ o υ o υ o z υ υ oD υ o z fit; CQ CD D Q A oo υ o o o o υ o υ o υ υ υ vo r- oo en o H CM rO T in vo !— oo <Λ θ H CM C τ ιn vo t— co σ> o H CM ro τ ιn vo r- oo cΛ θ H cM ro τ ιn vo ι— oo cΛ θ H CM ro τ ιn vD [— oo ιO ^{( (}0 ⁽O ^ M^, "3^, ^ <^^, ^^ι ^ ^^ι V 'S^| ιn ι ιn ιn ιn ι ι ιn ιn ιn Φ Φ Φ Φ Φ ^ ^• r^• r-• ^ r-• ^ ^ ^ ω (X) oo _ co ω ω _ o VD VO CO VO VO VO VD VD VO VD VD VD VD VD VD VD VD VD VD VO VO VO VD VD VO VO VD VD VD VO VO VO VO VO VO VO VO VO VO VO VO VO _> VD VD VO VO VO VD VO VD VO VO CM CM CM CM CN CM CN CN CM CM CM CM CM CM CM CN CM CN CN CM CM CN CM CM CM CM CM CM CM CM CM

oΣΣoΣooΣoΣΣooΣoΣoΣΣooΣoΣoΣoΣoΣΣoΣooΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ EH H EH H H H H H H H H EH H EH oHoHoEHoHoEHoEHo ΣΣ ΣΣΣΣΣΣΣΣΣΣΣΣΣ∑Σ EH H EH EHoEHoH HoHoEHoEHoEHoΣΣΣ EHoEHoEHoEHoEHoEHoEHoEHoEHoEHoooooooooooo A A A A A A A A A A A A A A A A A ft A A A < A ft A A A ft ft A A < < ft A A A A ft A A A A A A A A A A A

VD oo ^•» T o o o oo o o cM CM VD ro ro vo t— vo ιn ιn ιn τ ro cM H ro m <Λ in cM θo oo r- CM 00 H oo in T CM O t- H -qi O H i— vo in t— oo t- H ro ro τ ιn oo [— in oo r- t- H VO t— VD H CM in r- O O O in θ H VD CΛ r CΛ T <Λ H T oo t— oo r— in co m e— oo co H co co oo H vo r- ιn o ιn τ τ cΛ oo cn co o ιn vo o oo co H CM Co co in o vo T OO cM O CM CΛ O in ro co in r- H ro cM T H CM O OO H OO CO H Γ- OO H ro cΛ o r- cM in in oo T T in oo cM H O O vo vD '-j o t- oo vD in _'τ rθ τ cM CM CM CM _'T CM CM H θ θ H CM co cM ro τ ιn cn co cn r- oo oo vD r- r- ιn ιn τ rθ T CM τ r T Cθ ιn vO CM CM H O (Λ CX) CΛ CΛ CΛ CΛ ΓO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H H H H H H H H H H H H H H H H H H H H H H H H H O O O O O O co lrι _ in cM O CΛ CO T ιΛ o o e

CM CΛ CΛ in t— t— cD in i' co vD in r- cΛ cn cΛ H in H CM oo cn ro vo co cΛ vo ^i oo ro T O CM 's. ro co cΛ r- o tΛ CM in cM in cΛ eΛ ro o oo ro m r- o ro vD cn r cΛ co vθ H in τ o o ιn t— τ vo eΛ cΛ in vo cM cn t— ro cn r— in H C H VD T O M ∞ o in o H c i— -T H in t— τ eΛ in <Λ τ ιn τ ιn H θ vo τ ιn ιn co ι

^ lrl H H ι c^ι (Jl Φ lD o w ^ (00 (Λ ^^ H « lf lD ^ o o ιη ^ m m » n o ^^ (ll o m H H H H ιyl (O ιn oo (^l Φ m ιo oo N !! ^ ^ (η ( ( ιrι o in vo m in in ιn . ln . ln ιη N t ιn 9 lΛ 'l' ιι1 « - oo oo oo oo oo oo oo o OoO oOoO OO OO CO CO

ιo ιn ln Φ ω ^ ^ ^ ^ ^ ^ ^ (o s ω _ _ lD flo ω _ _ _ oo _ ⁽Il m ι!1 lIι ol ⁽ll o o o o o O H H H H H H H H N N ( N ^ι ^l N (^,l

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rO rO rO rO r^

CM CM CN CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CN CM CN CM CM CM CM CM CM CM CM CM tN CM CN CM CN CM CM CM CM CM C^

( CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ x r r r w w vi w w vi tn ui x x x x x x x x x x ti ^ ti ^ H' H- ^ ti A A A rH

J J hl U U U U (i; ι-; «i; H Eι H B tι t< H H fH EH H t< EH Eι h H O O ϋ ( U y H H H H H H H H > > > > > > c5

H CM H H CM CM H CM CM H H H CM

SI rt; rtϊ m CD Q Q fit! CQ CD CD fit; co cD A CQ CD a a rt! CQ CD CD

Z υ o z u o o z υ o o o Z oozυυυυυυυυoυo z o υ o o υ o υ o o o co z o υ o υ o υozooυυυ o z

rt rt r- ro T CΛ l— CM H OO VD T oo cM CM CΛ ro ro vD ro o o o o1 0 o o -l

H oooooooo U oooooooooooooooooooo oooooooooooooooooooooooooooooooooooo

H H H H o π Φ H ι» ^ Φ ^ N ^ o ^r m ^ N ll^ o ιn o ι>l Φ m ^ H ^ (B N co ι' ^ ■J^, eo v (ι ιn H oo ιn (O o o ιn ιn ^ ιn ^l> o ^o ιtι ιι1 H H VO O CM ιn m oo o vo vo vo cM '-- ro τ ro vo o co ro o o H VD in ro ιn cΛ in o vo t— CΛ OO OO VO O Γ- in T o r- o oo r- oo ro o in in t— « N ^r co H m in π ro r r- m o t^ι ιη ^ * ^ ^ (Λ v co ^ fl ιn v •» o cn (^ι Φ ^ ιn N H (O ^ Φ H ^e H » ιΛ lΛ H ^ ι Λ ιs (^ι ιn o ^ ln H ll1 lΛ ^ ^ ω n ^ι oo -

CΛ o CM CM ro oo oo r- vD ιn τ τ ro co t- vo m m ιn τ f ιn ιn m τ ro cM H eM o _ o _ o o T co in in vo t— t— co o o oo oo oo co r- VD t— VD O O O o H H H H OOO OOOOO OO O o o o o o o o o o o o o o o o o o o O O O O O O O O H H O O O O O O O O in H oo oo cM oo vD in o oo r- o co vD in ro oo cM t- vo o σi cΛ cM in cΛ ro o o cM in o T in o oo o vo vo σι ιn ^^, τ τ *-ϊ« co τ oo co oo cM CΛ r- ιn cΛ oo [— r- t— «-r cΛ c c cΛ 'j o o r- cΛ r c r- cΛ in cM CΛ in ιn r vθ '--jι vo H σv »-ιι τ H CM θ cΛ r- in in t- CM VD in in in cn vD O^ cM CM VD CΛ 'aⁱ cn H oo ro r- t— vo cM CΛ o ro o in cΛ T oo H H ro cΛ T in o in i— o t— ιn vo oo oo τ o co ιn oo τ r- oo H CΛ O T O Λ T CO VO CM O CΛ CO r- CΛ CΛ r- CM in H O CO

H (^ι cv! ^ι ^ c^ι tv! H (^ι oo N l ^ N '. ιn ιn ^ ^ Φ ^ Φ ^ ω Φ ^ ^ ^ Φ eo ω _ Φ Φ ^ v f OO ^ M^| N (<l H O ()^ o <J^ ι_ o o -l in in in in in n in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in m

CM cn H co ro r- H O H in in vD CM oo ro cM rO rH ro 'qi t— o H in CM oo r- cM τ t— t— o r- vo t— co t— ro cM in cM VD T O o o co ro o o vo H co cM r- T

O VO H OO OO in oO H OO H VD CΛ CM T in t— co in cM t— VO VD H T VD CM cΛ in in o H in vD CΛ o ro in r- o cM H co H in t— VO OO H OO T O CΛ CM OO CM CM oo m in H CD T H CM H T VD in cΛ CM ro o o ro in i— vo oo oo in H cΛ H in vD CΛ oo H H in vo vo in ro T in cM CM ro H oo oo oo in in cM oo o in vO "-- vD vo r- r- vo i— oo cn oo cΛ cΛ oo r— oo cΛ oo o o H CM ro ro T oo oo oo vo r— oo cn o O H CM in T in T T in co ro ro cM H O H O o o H CM O H cn σι σκΛ σι oι σ\ {jι σκΛ σ\ θMs σι iΛ (Λ ^ o o o o o o o σι σi Λ (ii (jι iji (Λ o O O O Cn cΛ CΛ CΛ CΛ Cn cΛ CΛ CΛ CΛ CΛ CΛ cΛ CΛ CΛ CΛ CΛ cΛ CΛ CΛ OO

co m ro co ro ro ro co ^ τ τ τ τ ^,T 'τ τ ιn ιn Ln ιn ιn ιn ιn ιn ιn ιo co vo co ιo vo vo vo vD vo vD vo r— r— r- r— co oo co co co co m cn cΛ CΛ cΛ CΛ cn eΛ o co ro ro co co ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro n ro ro ro ro r^

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

D S D S D D D D Z Z Z Z Z Z Z Z D D D D D D D D - PS l- l- l- f- l- l- l- lll l- K l- ^ ^ ^ ^ l- I- tf tf ^ l- I- Iil U ω ω iil lii ω Z

, l H HH HH HH HH HH H3 O W W W W W W W rα HH HH HH' HH HH rH HH HH^{, H} ^ 0 0 0 0 0 < κt; fit; rt; rt; rt; o θ CD O O O O O O EH H EH H H EH H EH H EH EH EH O O C CO CO C CO CO H H H H H H H H rt;

H CM H CM H CM H H CM CM CM rH H rt! CQ CD Q ω w fiC m c Q Q fi m c Q ω r-i W < O O O O O O O υ o υ o z o o z υ υ υ o o o o o zυ ⁽( (oH UυQυHυQυυυN Koυozυυo rtolυCQ Ooυoz rtυJ CυQ OoOυQoυo in vo r- oo σi o H CM cO 'T in vo r- oo cn o H cvi ro T in vo r- ∞ cn o H CM ro ^r in vD r- oo cΛ O H CM rO T in vo r— co en o H CM ro T in co r- oo cn o ^ f M^, ^ ^ ιn ιn ω ι ιn ιn ιn ιn ιn ln Φ Φ Φ Φ Φ Φ Φ Φ ^ ^ ^ ^ ^ ^ ^ ^ ^ w ω α⁾ oo cD ω ro oo co ω cfι cfι c! m m <Jl Λ <Jι crι o o r— r— r— t— r— r— t— r— r— r— t— r— r— r— t— r— t— r— r- t— t— I— t— r— r— r— t— r— r— r— t— t— r— t— t— r— r— t— f— t— t— t— r— r— t— r— r— t— r— r— r— r— r- r— r- oo CM CM CM eM CM CN CM CM CM CM CM CM CM CM CM CM CM C CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM C^

∞ rH rH ΣoΣ Σ oΣ Σ ∑ΣΣΣΣΣΣΣ∑∑ΣΣΣ∑∑∑Σ∑∑∑∑∑∑∑∑ O o EH EHoΣoΣΣ H EHoEHoEHoΣ HoΣΣ EH EHoEHoΣ HoΣ HoΣ HoEHoΣ EHoΣ HoΣΣΣ ΣΣΣΣΣ∑Σ∑∑ΣΣ HoEHoΣ EHoHoEHoEHoEHoEHoHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEH o A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A ft A A A A A A A A A A A A A A A A A A A A A A A A A

rt t- ro cM O CM r- vo ιn τ cM o m vo cM js iη r— co O VO H in σi VD CM CM H CM Cn 00 CΛ 00 C0 CΛ r- C0 r- r- C0 rO CM CM CM CM CM CM CM CM CM CM CM

O O OOOOOOOOOOO OO OO OO O OO O O O O OO OOOOOOO OOOOO O O O O OO OOO OOOOOO OOO OO OOO OOOO O O O O OO OO

PM H H H H H H cn cM ro oo in cM αo '- r- oo in co cM oo r- in o vo σ> r- oo ιn τ o r- t- o oo T r- ro H H in o H r- H CΛ OO H OO H H CM VO in CM CM OO Cn CΛ '- rO VO in in rO T in o t— VD CM CM '- oo vD CD rO '- CΛ Hjⁱ cM CM ro cn r- r- r- co T T H CM CM C— r- O H H T CM o r- H oo cM rH r- T VD cn ro cM CM vo ro cn cM oo o oo o H co vj Λ in in r- oo r- H cn co ro ro en o co o vD ro o in cM o r- oo vo H in m eo vo cM cn cn ro o in cΛ vo oo r- oo vo cn o oo

H ( ro n (^l H H N N H H ι ^ o H N ^ « ^ Φ Φ Φ ω - ln ^ ^ ^ ιo ιn ^ ^ fl ιη H ω Λ (n o o l m ol W o o N ^l N n ι ι ιo ^ ( ιΛ ^■»

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H CM CM rH H H H CM CM CM CM CM CN CM CN CM CM CM CM CM H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

^ in in co Λ CM r- c vo t— r ro cM VO H t- H ^ co ro H CΛ D O 'T T C ro H Co r- O H CM oo H in in oo H O O in H H T rO H T VD CM CD VD in σi CM r- T C c T O ^ o co o c co in vo cM CΛ co r- in 'T in cM in in o c C CO H 'ϊ o r vD r- ro c CM CΛ H CΛ H VO CM CO CO VO H O CM rO T H t- H T m oθ t- T C» H VD CΛ H CO H O ^ CO t- t- t- rO <Λ H CM r- r- CD t- in r n t~ r- CO OO CM H '3' H r- VO OO H H CM rO CM CM O r- CO rO H CM in '- CO O H

OO Cn O O H OO CO VD VO T T co τ ro cM in ιn ιn τ vo t~ ιn ro ro cM H θ θ θ o cΛ cn o o H CM θ θ θ cM CM ro σι oo cΛ r- r- vo ιn vD i— oo co vo vo τ τ ιn ι ιn '- "- τ ^ *^^ ^f ^P ^3^ ^ * *^3* ^1* ^3* ^3* ^J* ^ * ^3* "'■3' ** * ^P '^^ ^^ ^3* ^3* C ^ϊ* ^J' ^*^^ * * ^*3* ^3* ^* ^3* ^3* T ro ro ro ro ro ro ro ro ro ro ro ro ro

VD VD VD T T CM H in O rH in in r- ro in c .M. t.— i _n. r.- c .M. o ιn τ τ eΛ cΛ t— ro cΛ H in vD CM Vo cM O r- O H T CM O CΛ cn r- H T CO ro cM r- in H M VD ro m in ^r O T Vo o vo H oo CΛ vo in T T CΛ CΛ CM in OO CΛ O T H T VO OO VO VO CΛ r- VO Ln in OO O T T H H OO CM Cn 'T rO H O O H O CΛ H r— OO CΛ i

CO T CM rO CM O O H o o t— ro r— i— o o oo oo cM H CΛ o oo vo cΛ oo ro vD H m o ro oo ιn H in o ιn H VD cn o cM oo o oo oo cM r- ι— τ τ eo o ιn

<Λ CΛ CD r— o _o <)o ^ lI ^ ^ ιn ln '» n ^ ^ flO ln ιn ιn Φ « ιn n ln v ln Φ ^ ω ln ιo ^ ^ ^ ιn ^ ( H H σ^ ω _ n N ^ v ln ω ιn r- ι^,l ι^,) Pl (^l o 00 0000 CO 0 m0 ω _ ω Φ ω „ Φ m ω m <_ ω _ co co „ ω αo „ oo oo ω ω ω ω (_ m α> ∞ ω co co ω ω ω r-- r-- r-- ω ω ω ω co ω _ _ oo t_ _ ω _

o o o o o o o H H H H H H H H H H CM CM CM CM CM CM CM co ro ro n ro co ro ro ro ro ro ro *τ τ τ τ τ τ ^,* 'T '-τ ιn ιn ιn ιn ιn ιn ιn ιn v^

^ⁱ ^3* ^1* """S* "^■-S' ^* "^^ ''S' ^T* ^3* ^3* ^3* ^T ^* *SJ* "Sj* ^J* ^* ^P ^J* ^3* ^* ^3* ^-S* *** ^* ^-J* ^I¹ I* ^* ^J¹ ^* ^* ^* ^3* *3* ^3* ^* ^* ^* ^* 'ζf ^ * 3* ^* ^3* "ζ-* ^,13' ^* KJ¹ ^* ^* ^3* ^* *3* ^*

Z Z Z Z Z Z Z W W W W W W W W W W P_H C_H O. I_; 0_H 0_H C, O_ O_H C_H C_H PJ ^

W W M C W W OT H H H H H M H H H H S K E S .Π W « >H < :>H :H :M H ^

H CM H CM fit! CQ CD Q Q A CQ CD Q Q ω ω fit! CQ CD O cQθ HQ Hω CQM CωM ι n o α Hω CωM fit! CQ Q Q A CQ O Z O O Z oooozozυo Z O O O O O oυooooooooozoooυozυo zooooooozυo

H ^ι ιη 'l^| ln ^ o30 O H ( ιη ^ ln ιo oo (I^ O H N ι0 I ιn ω α! <Λ O H N lo ^ ^ Φ ^ (» m o H ι r ^ ln ιD ^ ω _ O H N (^ 'J ln - o o o o o o o o o H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM ro ro ro ro ro ro ro ro ro ro T 'T 'T T 'T T T T T 'T in in in in in Ln in „ „ co ω oo _ _ _ o _ m m m ω ω _ φ _ aι n co ω ω _ _ m _ ∞ _ _ ffi „ oo <» co ω _ m ω _ _ co cD ω ω _ ω _ ω co ω ω co ω

CM CM CM CM CM CM CM CM CM CM I CM CM CN CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

00 se

Σ Σ Σ

© o Σ Σ Σ

O O O o o H

O rt! A A A A A A

rt l- ro •1- VD co ro vo σι co ro r- r- cΛ τ ro ro r- ro ro ιn oo o r- CM in cΛ ιn vθ 'qι r- oo H VD r- ι— oo cn r- ιn t- cM r- <Λ CΛ oo cM θ CM CM τ r- H vo o ιn cM r- cΛ rs vo "-H H OO CO OO H CM CO r- CM '- O rO O t— in i— H O in VO CΛ rO CM H CΛ CΛ CM T to ∞ ^ ^ in H 'T co in o vo in 'T Csi cΛ oo in r vD CΛ '-i c CD r- vD in o

© © o ro cn t— t— r- vo vo vD VD in ιn ιn '3' cs) H H τ τ τ ιn ιn r- co cΛ oo ιn r- r T CM H O CO VO ιn τ ιn vD t- cn σι eΛ o o cM ro ro cM ro ιn ιn vo σι ro oo CΛ rO rO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H H H H H CCMM CCMM CCMM -CM^• C-^»M^• C"-M^■ ro co ro ro ro ro ro ro ro ro ro T 'q' oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H oooooooooooooooooooooooooooooooooooooooooooooooooooooooo U PM HHHHHHHHHHH

VD VO O VO m rH VO T H CΛ t— o ro oo T t— VO H H ro m cM H O cn cΛ H O T T cn oo in t— T CM CM t— T oo co in H oo r- r- o r— cM t— T CΛ o r- cM cn t— t— OO CM OO CD H CM in CΛ H I— oo cM in o in o σi r .o . o _ o o o vo cM c cΛ ro cn co H r— o ro ro r- ro ιn H <Λ τ t— to cM ^r vo in vo in in o cn r- oo o o cΛ H T in vo H t— cΛ r- H o oo r— oo t— o in oo o ^■_o. v'o" o^ o τ H r- t- o *-τ τ cM CΛ t— cΛ CΛ r- H r- H rO 'T VO e H CM t— vo ro T CM in r- ro Ln i- r- v ~D i „n, t .— ιn, τ -» v_o t.— i_■— i_■— v_o. o _o. c-n. r _■- c-o^ r_■- o^o r- eri co o H ro ro ^. in T H CM H H O oo oo co r- Φ co N n ι») ^ ιn ιθ f ^ ι>i (θ (θ N i v <* m Φ r- h

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM cη rO rO rO rO r rO rO rO rO rO rO r CM CM CM CM CM C^ H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

CΛ CM H OO CM O CΛ H T VO OO in t— r- in ro cM T CM CM in r- co cM r- r- o in H H H τ '«. θfι oo o oo ^r oo ιn <Λ r- cM ro cM cn co oo cM CM CM in ro ιn oo o ro vo t— oo r- T H O CM t— ro T r- cn o cΛ co o cn cΛ in o in cΛ oo oo in in ro r- ro t— OO H CM in T OO OO O OO O CM O t— t— CΛ rO CΛ in VD T CM rO r— o in vo cn o r- σ> τ H CM in <Λ ro o τ m τ ro oo cΛ ro r- CM CM in o <Λ o co in VO CΛ CΛ H O t- in t— CM T OO H rO in CΛ VD H O H CM T H CM

VD CO VO T rO '- CO rO H CO CM rO H O CΛ CΛ H CΛ OO CΛ OO OO CΛ O O O r— r- VO T τ ιn τ ro co ro τ ro ro cM ro ^jⁱ H H θ o oo oo cΛ oo t— oo r- oo oo ro ro ro ro ro ro ro ro ro co ro ro t ro cM CM ro cM CM CM CM CM CM ro ro ro cM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rH H H H H H H H H

^ H m H N H l H Φ ι o ω H ιn ιn v o ιn ^ o3 n M H lD (o oo (Jl v oJ fl H H 1I^| Ol Φ H V ln (^ι oo N ι-• v ^ (ι co H r• ^o ^ m r- o o] r¹| ιn H ^ v ^ oo Φ m ^ ^ » ^ (ι o (D N '» ιη ιη ffl ι^ ( ! W !D ( ra Φ n ^ ιo o N _ t ln N ^ O H m β ^ N ^ en ^^ ln m v oo ffl ^ ^ ln n ^ n oo N Φ H ln ^ι ^D α! ω ^ ^ o ιn o ιn H ln Φ o r^ ι o (Λ ^ ιn a fO <^ι ^ N Φ O! ω Φ !D ^ o o _ '» Φ ^ Ol ιn ^ lrι tn m ^•J^ι

Cn oO O CM CM CM CO T in in CM H H o en oo m H CM H CM CM rO T ro in H CΛ H O O O CΛ OO t— OO VD O H σt CΛ CO CΛ CΛ r— CΛ H CΛ O H CΛ O 00 00 00 r— r— oo oo oo oo oo oo oo oo oo oo oo oo r- r- t— oo oo oo oo oo oo oo oo oo oo r- oo oo co oo t— r- r- r- r- oo oo r- t— t— r- t- r- t- oo r- oo oo r- oo t- t— t—

Φ Φ Φ ^ ^ ^ ^ ^ m ra co ∞ m m oo cn βi is oi m iri iΛ iΛ Oi o o o o o o o o o o o H H ri H ri H N N N C N N N ri i t Pi ^■T ^ 'T ' 'T ' 'T ' T Tⁱ ^r T T T T T T T T '^ T '^ ^ ^ ^ ^ ^ i in in in in in in in in in in in Ln in in i in in in in in i in

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CJ CM CM CM CM CM CM CM CM CM CM CM C^ CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ CO CO CO CO CO fiζ fiζ pH ^" rl ^■ ai cζ rϊi iύ & c c oi ec ct cύ rύ ω

A A A A A > > > > > > CD CD CD CD CD O CD o o < rtj rti rt; rt; rt! rt; rt; rt! ri: c co OT CO CO CO Cu Cu pH C-i CLi C-i Cu M a ili a-l

H CM H CM H CM H CM H CM O Q Q A CQ CD A CQ CD CD fit; CQ CD Q fd ω «! H1 C5 D ω N X II fiC ta fC O O O O O O O O zoυυυυoz υυυυo υCoD oooz oooυzυzzυozo υoz QυfiυCυQ CυDυoziυυOQ CυD r- co cn o H CM ro τ ιn vo r- ∞ rΛ θ H CM ro τ ιn vo r- e» cn o H CM ro τ _l vo t- ∞ cΛ θ H C

_ ιn ιn Φ Φ Φ Φ Φ ^ ^ ^ t-- ^ ι-- t-^» ^ r ^ ω en ω o co o (B lJo ro co -l crl (J\ σl σl 0 ι3 m σl m o o o o o o o o o o H H H ω ω ω ω ro ro ∞ ω ∞ ro ω _ ω ω ω ω _ ω _ ∞ ω _ _ ω _ ω ω ω ω oo ω ω _ ra co ro co co ro oo ∞ ro co m « oι m σι m m σι crι (iι m σι σι

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

00 rH vo rH rH O o Σ ΣoΣoΣoΣoΣoΣoΣooΣoΣ ΣoΣooΣ ΣoΣooΣ ΣooΣ ΣoΣooΣoΣ ΣooΣ ΣoΣoΣoΣoΣoΣoΣoΣooΣ ΣoΣoΣoΣoΣooΣ ΣooΣoΣ ΣooΣ ΣoΣooΣ ΣooΣ ΣoΣooΣ ΣoΣooΣ Σo o A A A A A A A ft A A A A A A A A A A A A A A A A A A A A A ft A A A A A A A A A A A A A A A A A A A A A ft A A A A

rt rt (- ro o ro vo in t— Γ- CM OO VD [— CM T O H CM VO H t— r- ^. O H CΛ CM CΛ θ rθ ιn CΛ r- CM cn cn H VD r- cΛ r- o cΛ co vD ro o vo H in r- in cΛ r- cΛ t- vo ro S r- in cM VD oo o vD in oo co t- ro co H O in oo H VO VD oo ro o co cM r- H CN ^r o i¹ in ^•- eo H in <f ff\ (vι o w <Ji ω i (θ i ) ix) H iη Φ H Φ <» ιfl θ

© _. © CΛ O CM H OO CΛ r- VD t— CΛ τ VO in *- T CO CM H H r O CΛ CΛ CΛ O O CΛ CM O O CΛ CΛ O O CO O O H CΛ OO OO OO CΛ OO VO VO VO VO VD VD t- t- r- VD

CΛ s T in in m ro ro ro ro ro ro T T T ro ro ro ro ro ro ro ro cM CM CM Co ro cM ro rO rO CM CM rO rO CM rO rO rO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM

O OO O OO O O O O O OOOO OOO OOOOOO OO O OO O O O O O O O OO OOO O O OO OOOOO OOO OO υ O O O O O O O O O O OOOO O OOOOOOOOOOO O O O OO O O O OO O O OOO OOOO OOOOO OOO OO

PM t co H ^. o in H in m ro O '- co o t— VD CΛ CM H in o _o e.M..r- o H oo in co ro oo co r- ro ro co o ro vo H T CM rH H T ro r- <Λ oo H CM in t- τ vo ro ro cΛ io o ro vvwo v_O< T-- ιO_ι ιH-ι inι inι ιo_> ιn CM Cn VD ^ⁱ 0O in 0O CM CΛ VD σi H VD CM ro r- in cM VD in o o H o o CM o oo r- r- in oo o ro ro co H in in VD 00 CΛ 00 CO t— oo in ro t- r- CM in O O H vo r- vo ro co cΛ O CM in oo ι- o cΛ cn oo ro H θ ιsι

OO VD VO r- VD VD t- OO OO O H CM rO rO T OO Cn cD OO CΛ CΛ CΛ O H CM CM T CM CM ro ro T in vo in in ro vo t— vo r- cD CΛ cn cΛ H H CM H CM ro ro T CM H ro ro ro ro ro ro ro ro rO T '. ^ ^ T '. ro ro ro ro ro ro rO T 'T •T _'T T T T T 'T _'^ 'T T T T T T T T 'er 'i- '- '. '. i in i i in in in in i in

HH H H H H H H H H HH H H H H H H H H H H H H H H H H H H H H rH H H H H H H H H H H H H H H H H H H H H H H ι» H H ιn ra (O ω ^ ln ^ ^ H (^ι ω m ιn o^ m ω N ^^ ^ H ιn H (O N <^l (O O ^ ω <» ffl o n o ιη <Jι N c! H ιn ι^ι n Λ ffl o ω N l^,l . ∞ vo cM co r— '3^, H in cM '3^, ro r- cn r- in H CM CM o ro H CM r— o o r- cΛ ro t— cΛ in in H oo co in cM vo H t— H vo cM cn co ro ro ιn ιn ιn τ oo cM cn ro vo

_ „ coN H α) l(ι ^ ^ ^ Φ ^ ιD o(^ o ^ Φ Φ ιfl o coo N H Φ ^r MO^ (Il ^ 1 o ^ v H (D ιη o oJ HO ^!) ιJl(i l') (o o o ιn ιn ιn ι^ι r') t— oo oo oo r— r- vo ιn τ τ co ro ro rθ "3^, t— oo r- vD oo oo r- O O H H O rH O rH O O CΛ OO OO CΛ H H rO rO in rO CM CM CM CM CM ^' CM CM CM CM CM CM

H H H H H H H H H H H HH H H HH H H H H H H H CM CM CM CM CM CM CM CM CM CM rH H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM r t— O VO r- OO C T CΛ oo ro r- in ro cΛ i— oo r T r- cM Λ CM cn H CM ^ι^, CM CΛ oo co o 'a' θ θ H r- cΛ H cΛ r- ιn r- ιn cM τ r- τ co o r- o ro t- ιn vo τ H H τjⁱ H in rθ '--r o o cM in τ oo m τ «- τ co cM rH oo ιn ιn τ vo ιn . cΛ CΛ τ ro τ ro ιn rθ H oo r- ro oo H oo H H r H CΛ «-ιι oo H oo τ o _) i

^■» H -J φ (Λ O Φ r*l CΛ t- τ ro vo cΛ r- ιn τ ro cΛ '-ιi CM ro r- ro i- rΛ CM H ro in o fM rH CM VD CM VD vo in H in r- '- 'sr vo vo o in ro cΛ o in vD 'ϊ' o

H H CM CM Vo co vo in in in in in vo t— ιn -«. ιn co cM CM H H ro ro co rθ 'τ ιn cD t- cM CM CM rH θ (Λ oo <Λ H CM rH H O H O CM CM "-i H H O O Oθ r- CO |- eo co co co r— r— t— r- r- t— t— r- r- r- t— r- r- r- r- r- t— r- r- r- r- t— t— t— i— i— t— t— t— r- r— vo vo vo r- t— I— t— I— C— t— t— r— t— t— [— t— t— VD VD VD VD

n ⁽η n n ιη ⁽O oo ooHH HH in in in in in in

CM CM t CN CM CM CN CN CN CN CM CM

CΛ CO CO CO W CO Z Z Z Z Z rt; fig x x _{D D}

M H M H H M

X X S S X S (] IJ U U U II; A CD CD CD O rl rl π rO T9 ilnn »vo t^- ccoo mcn oo HH (^ι ιη ^ ln a ^ (. o) O H N co ^ ιn Φ ^ a) m o H ( ιη ^ ιn ιo ^ α) (^ι O H M t ^ ιn a ^ ιIι (l O H N ιη ^ ιn ^D ^ co

H H H H H H H CM CM CM CN CM CM CM CM CM CM ro ro ro ro ro ro ro ro ro rO T T T -T _'T '. '-ai T '^ cΛ cΛ cΛ CΛ CΛ cΛ cΛ cn cn cn cn cn eΛ cn cn cn cn cn cn cn cn cn cΛ cΛ cΛ cΛ cΛ CΛ cΛ cΛ cn cn cn cn cn cn c^

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

00 r^ o ΣΣoΣooΣΣoΣoΣooΣoΣΣoΣooΣ∑∑ © oo∑o∑o∑o∑o∑o∑o∑o∑o∑o∑o∑o∑o∑oo∑o∑∑oo∑∑o∑oo∑o∑∑ooΣ∑o∑o∑o∑o∑o∑o∑ooΣΣoΣooΣΣoΣooΣoΣooΣΣoΣo

O A A A fC A A A A A A A A A A A A A ft A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A

ro JS co vo vo σi CM r- cM t- o cn i— H CM CM H Cn 00 H CΛ in cΛ CM VD OO OO CΛ CM rH CΛ Cn 'T in cn 00 ro vo r- H t- vo H CM in cΛ in cn

-S CΛ O CΛ CM CM in cM lΛ ^r t— in cn 00 H <Λ H H ^< ιn ro vo cΛ ro ιn cn ιn τ ro O CO CM VD CM T H O M Φ O N V O Λ O

3 ro H en 0 r- 00 r- r- lo r- vD in r- oo cn σi σi σi o H ro in cD CM ro ro T oo in oo o cM VD co r- r- r- r- t— r- co oo cn cn cn cn CM CM CO

N (N C\I CSI N N N N N < M n t rt Λ ( ( IO ( n r rθ ^ ^ tO (θ n f (O f (0 ( I (^,1 l^,l ( IO t ^* ^3* ^3* ^3* ^3* T iji T

H 0000000000000000000000000000000000000000 0000000 O O O O O O O O 00000000000000000000000000000000000000000000000 O O O O O O O O U PM rH rH rH rH rH rH rH rH rH rH rH rH rH

OO VD CΛ H T cn T O O CO CΛ V _D in c T 'Λ vo o

O H O CM O C ιn m ιn ιn ιn H

H r- H H in cΛ H oo H H t- σ^ oo o eΛ co in r ro cM cn r- in in cM ^ CM CΛ CM r- vo cM oo oo in o in rH H Co ro ca o n r- in w co cM CM r^

Φ O o o ιn Φ a ^ « m H m ^ ffl cl Φ H O H N ^ Λ H lO Φ ιn ^ φ φ » o ι Φ o τ^ ιn Φ Φ » ιn ^ ^ ^ ( ! Φ N (vι (0 (η H N lO H m Φ r>) ιn ol o w o ιo ^ H Λ m ^ co N lrJ Φ o ^Jl O ( ιn ^ Φ Λ Φ _ Φ N H m ^ ^ ^l H ^ n m ( N ( n ιn flo ^ o Φ oo H m o Φ αJ Ol H Λ (^ι

00 *T CO T H O O CΛ O CΛ OO O O H H rO O H O CΛ CO r- Γ- O H O H H CM OO T ΓO o CΛ o o o CΛ cn H CM O H CM CM O H CΛ CM H CM O H Cn eΛ CM CM CM CM CM CM CM H CM H H CM CM CM CM CM CM CM CM rH H H H CM CM CM CM CM CM CM CM CM CM rH CM CM CM H H CM CM CM CM CM CM CM CM H CM CM CM CM CM H H

T OO in vO T CM H '-jⁱ t— o r- CM CM in ro H CO VO CM H i- H in o ro cn H in in ro ro r— o cM T H τ τ ιn o oo cΛ oo oo r- ιn ro τ o r- CM CM θ vD

CM O H O T T T OO O OO O CM I— CM Cn VO VO H CO H H CM Co t— H oo m a-i VD CM Vo m vo r- oo cM ro cn in m T oo ^r vo cM ro T VO o H T C CM oo H T Vo oo r- vo ro m ro H oo t— o cM o t— t— m T o vo oo ro m vo oo r— <Λ in m vo H ro «- H cn cM '. o oo in r— o co in o T co i m t— 00 ^ Φ Φ _ ln ^ ( '^r ^•» ln ^ ^ 'q¹ ι N ^^ N to v v ιn H ( O Ol oo o^ ω w <s ω ) ω ^ ω » Φ Φ Φ _ o ( ^ ιo ι c^ι H o m m (! „ Φ Φ Φ Φ iθ Φ Φ Φ Φ Φ Φ Φ in ιn ι ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιf) in m ιn ιι ιn ιn m ιn ιn ^^ι « * 'j

H H H H H H N ⁽ N N ⁽^l ^l N ⁽0 ^ ⁽η ro t ^ ^ ^ ^ 9 ^ ^ ^ ιn ιn ιn ιn ιn lrl ιn ιrl ln Φ W Φ Φ Φ lo ιc ^ ^ ^ ^ ^ ιlo co (D a! co o^ _

D D D D D D Ooqooqo< (i! z z z z z z z z n n«nnnnwni- «i-i-(, i- i,JJJiHiHjjtf <ij; ωωι_ι ωc_ιω oH a, θH ^pH θH ^p- θH HH H H HH HH C coc c c c coco H H >H >H H >H >H >H H aH

H-i HH Hq HH HH H5 u Q_J CH CH CM pH M _la ^ ^ rt: fiC fiC rt; eC rt; fit; fiC fiC rt; H^ HH HH H^

H CM H CM H CM

CQ CD a Q a A CQ CD fit CQ A CQ o a a ri; co CD a ω si υ o υ o z A PQ U CD fiC CQ O CD Q O O O O O O O O O O O υ υ υ o z o o z oυ υυ o z υ o υ υ o υ υ o z o υ o υ υ o z A C υ υ υ o υ m O H N ⁽ ^ ln ω ^ to w o H N n ^ ιn Φ ^ ιxι o O H (ι n ^ ιn Φ m <) O H c^ι ιo ^ l ^ ιIι ιJl O H !! (n ^ lrl ^o ^ co o^ o H ^ι ιo ^■» -> r- r- ι^ r- r- r- r- ι^ r- t-- ∞ ∞ ∞ cD co ∞ ∞ CD m ∞ cn cΛ cΛ cΛ σ C cΛ cΛ cn c^

CΛ CΛ CΛ CΛ ^CΛ CΛ cΛ CΛ cΛ CΛ CΛ CΛ cn cΛ CΛ CΛ CΛ Cn cn cΛ cΛ cΛ CΛ CΛ CΛ cn cn cn cn cn cn O O O O O O O O O O O O O O O O O O O O O O O O O CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rO rO ro n oc rH rH rH Σ Σ Σ Σ Σ Σ Σ Σ © o O O O O O O O o A A A A A A A

r- ro vD ro r- o r- co r- vo H OO vD r- H I— T CΛ oo σi CM ^i' cn ro in in cΛ ro T CM O H VD T Vo o co cM oo cM O cn oo o oo cΛ T i— vo in cΛ t— r- CM oo <Λ ro rs H T Oo en ro vD t— OO CM O CD T r- ιn H θθ r- τ cM r H τ H ro o oo τ vo ro ιn o vo vD oo o cM r- r- o o cM in cM r- oo cΛ CΛ T CΛ oo t— in m c- _'qi o is

T T 1- T T T T T in vo T T ro ro ^ in r ro in t— oo cn cM CM H O en o cn cn cn 0000 o ro ιn vD τ r- oo vD τ cM H θ θ cΛ σι o ro co ro τ r- ro cM δ ^ * ^3* * ^3* ^* Kf ^3* ^3* *"*3* ^3* ^ ^* ^3* *3* ^3* ^3* ^1* ^3* Ki* ^3* ro T ro ro ro ro ro T T T T T ro ro ro ro ro oo ro ro cM CM ro ro ro ro ro rO T in

H 0000 _{0 0}0_{0 0 0 0 0 0 0}000_{0 0}0000000000000000000000000000000000000 υ 00000000000000000000000000000000000000000000000000000000

PH rH rH rH rH rH rH rH rH rH rH

CM t- cΛ H CM O r- vD in co o ro r- r- f Λ O N i OMn H Φ H in ro r- in vD oo cM ro oo H in in r- oo o cM CM H oo o vo o in in rH OO o r- vo ro cM in o vθ 'T 'T 'τ oo cM ro cM '-- co co oo o oo cn [- cn vD in τ [- ιn τ H σι ro ro ιn H H _> '-_' CO rO CM _{OO CO} CM rH CM o o •» _ .. _. _ _ .. cΛ _CM CΛ ro ro cΛ o cM r- cΛ H Co oo t— H T VO CM VO T I— H ΓO H •t-c T CM r- cΛ O H CD in r- ro o cΛ vo ^i oo oo r- o cΛ ro in -_'. r- r- cΛ co ro co tΛ

N M (N| N H H O (Λ (D 01 CD ft O t Φ Φ in ^ <» n ιi1 IO Φ 'l' V in « ^ n N N H O H O H ()\ H N O O O « M « ^ n v 01 » (Jl <D 0i ro „ φ φ φ in in in in i in Φ in in in in in in in in in i iΛ in in in in i in in i in in in in ^ in in in i n in in in in in in f -ϊ '. '. '. V _'*

H H H H H H H H H H H H H H H H HH H HH HH H HH H HH H H H H H H H H H H HH H H H H H HH H H H H H H HH

CΛ CM O CM VD rO lO O H OO OO T H H OO CM t- m H CΛ VD o ro t— co H H CM CΛ r- rΛ o o co H ro co r- r- in in r- CΛ T VD CM CM O O OO H t- CM T 'ϋ' VO in H T CM CM CΛ H CM in cΛ vo H in T oo σi oo o ro cM ro H O r- in H OO VD VD ^r VO VD CM OO OO r- V "_Oι C_Oj C_Λι Oι.j C-Λι V_D< iιnn H _) in r~ cn H r H CΛ vo ^i CΛ t—

CM T O H CM rH O CΛ H OO CO in in T T in ^I' CO CΛ O CM o vD CM oo oo in oo ro r- rH co ro vD oo T oo en vo cΛ in o ro ro in vo oo cΛ cM in ^j' H cn i' rH r- vo oo o H O O cM C CM co co ro o rΛi '^ 'T i vo i r- ^ in r r cM rH CM Oo r ^ T in vo oo oo cD rO 'T Oii cM rH O O n iΛ α}

H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H H H

CM t— in cΛ oo oo oo ro cΛ oo H cn cM cn o in cM O T H in '-ji ro vo in co vo o o ' H r- D in o o Mⁱ Λ o CcMM CO. . o _ o _ ro ro vo ιn τ cθ (Λ vo ro ιn ιn τ cn o vD ιn ro vθ H t- vo t- CM CΛ vo ro r- CM CM τ o cM H H in τ oo ro ιn <D τ vo r H CM oo r— oo o r- H rθ '3' ro c -M- r —o r -- ri Ol^,) lD - ιxι ■l' oa Φ ^ •J cΛ CΛ oo in cΛ T i— oo in cn co in en oo oo T Vo o vo H m m m H H VO H ro vD H in co σi vo co r- vo T T H oo cM ro cM CM H !^| o o ol lO [! lJl Cι ^ ^ co ιn ιn τ vo vo vo ιn vo ιn c- oo cΛ cΛ oo oo cn o <Λ oo r— t— H ri cM ro ^ in -T ro in in in o i T vo r- oo t— CΛ cΛ cΛ o oo o oo cΛ cΛ Λ H H CM CM CM ■τ τ τ τ τ τ 'τ τ τ 'τ τ _'T 'τ τ τ ιn τ τ τ _'» ι ιn ιn ιn ιn ι ιn ιn ιn ιn ι ιn ι ι ι ι ιn ιn ιn ιn ιn ιn vD ιn D

σ* cn c c cn cn o o o θ H H H H H H CΛi cN CM CM CM eM CM CM rn c r r co ro r τ ^ 'τ ^ 'τ ^ ' '^ τ-r^! in ιn ι^ Φ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ r- ι-- ^ ^ r-^• ^ ^ ^ ^ r• ^ ^ ^ ^ ι-- ^ ^ ^ ^ ^ ^ ^ r- ^ r-

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C

D D D D D D >π H H >H CH PH CH pH PH pH Z Z Z Z Z Z z z H3 Hg HH Hq H^ H HH D D r- D D D D D D ω ω ω ω ι_ι ω ω ω ω ω ω ω ω ω H H^ H^ HH ω w ω ω ω ω w co co co c w co rtl rti rtj rti rtj rt fitj HH ij

H-) H^ H^ HH H^ H^ o o o o c co co co co c κC rt; rt; rt! fiϊ ^ > > > > > > > o o o o o o o cH u C_ H CH u m CD CD cQ θ Q ω t-i Btj cQ α α ω ω si υoυυo C00 Q o o υ υ o o υ o z υ υ υ υ υ υ υ o υ o z o o o 00 in cD r- co cΛ O H CM ro T in vD r- oo cn o H cM rO T in vo t- oo cΛ O H CM rO 'T in vD t- cD cn o H CM ro -T in vo r- oo eΛ O H CM rO T in co r- oo cn o cv! N N C l π ^ n ( ( ro ( o ^^ ^ ^ 1r v M^ι ^ M^, v ^ M^, ιn ιn ιn ιn ιn ιn ι ιn ιn ιn Φ Φ Φ Φ Φ Φ ^ ^ ^ ^ r-- r~ ^-• o 00000000000000000000000000000000000000000000000000000000 ro ro n ro ro ro n ro ro ro ro ro n i^ ro ro n ro ro ro ro co ro co ro m co co ro cn c ro ro ro r^ so

ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ O EHOEHOEHOHOEH EOHOEHOEHOEHOHOHOEHOEHOEH EOHOEHOEHOEHOHOHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEH EOHOEHOEHOEHOEHOEH EOHOEHOEH EOHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEHOEH o A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A

rt I- ro VO oo co -s-ii in r— <Λ cn r— "T o co H VO O H CO VD VO O CM CΛ Γ- H 00 H H •rji vo H in H CM Oo m cn co oo ro T Vo t— CΛ O VD CO CM H CO o ro ro vo o cn ro JM ro ^■=. T vo o in vo vo r- CM O lΛ t— 00 VO CΛ ιn 00 t- H H o r- cM cn ro ι- H H θ cn o eΛ CM co ιn cn vo oθ '-ιi H Co t- cΛ O OI I UK I IJI TΓ ^

© ■Si © 3 CΛ rr NCM NCM CMl H N H ^^ H o ω 010 ^D ^ ιn >^ Φ ^ ^ co ^ ^ ^ α Φ Λ Φ oo oo ιn ( "» (^ι ιη N tO N <s^, ^ (Λ O H ri H c! N N H n (^ι ^^rι ^■» CΛ rO CO rO rO rO rO rO rO CO rO CM CM rO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM ™

OOOOOO OOO OOOOO OOOO O OO O O O O OOOOO OOOO OO O O O OOO OO OO O OO OOO OO OO υ H O OOOOO OOO OOOOOOOOO O O O O O O O OOOO OO OOO OO OOO O O OO O OO O OO OO O O O O O

PM H H H H H H H H H H H

00 o in CM CM o ro t— H in vD CM cn r- H cn H -ai O T iTi r— CM in rO T VO H vo in I— H t— CO t— OO t- t- H O H t— cM t— H ro r— vD τ ιn ιn θ H

T T H H in in T CΛ in r— OO VD H t— OO CΛ CM O O T OO CΛ lO VO CM - o co c ι— D ι ι '. '3' CM rH H θ CM H θ o rH H ro ro HH

T m in vo oo CM O cn ro cΛ ^»ι CM τ r— co n CM H ιn VO VD O 'J' ιn CΛ H H OO H CΛ O in O r- Cn τ θO H ^r T (Λ OO θ rO H ^l^, <-Λι V _O- C_Λι *C.M T Γ- VO «-J^I I— CM o oo H oo cn vo in t- o r— cM CM Vo oo ro o H in ^tι r- o r- vo cM in cM r- ιn o ιn o r- CM ro ιn cM CΛ ro vD oo oo cM i .n . r .- cΛ in . o _ ιn r- o _ in T H «- t— <J\ o co vo in oa r- O U"> «3^« H O H H VO O CM CM ro ro en o ^r o in o ro r- cM t— cΛ τ cΛ oo co oo ro ro o r- r- ro — • ~ oo» «cn* ^ΛcM^{I I}r—- -^r, "-,ⁱ -tii «o»o o '- CΛ αo o H

_ π N iθ N iθ 9 H θ v ιrι Φ » cn ^ ιη N H H n ιn n ^ » ιn Φ Φ ^ v ιn Φ N H iη N ri θ io ιn N i»ι n ιn ι^,) <f N in H o o oi ()i o o H H

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ in t— r- rO O H CM -T OO O O O H H O VD VD OO CM O OO H in in 'T CM Cn r- H CO O O H T OO OO H OO in O T cΛ T CM ∞ ro oo in H H Vo vo rO H CD Vo vo o o vo o vo r- ro vo cΛ vo co t— cM t— ro oo vo in in vD t- ro o tΛ CM CM H ro cM oo cM cn t— cM O oo co r- oo o H H O ιn VD H CΛ CΛ O CO CM CM CΛ CΛ -|i r- cM oo in r- ro r— cM in in ro o co co H O H o ro cn m H H T ro cM O T CM O r— in vo vo o cn H CM ro ro vo o ro in ro in co co vo t— H vo rO H CM cn ro ro ro co τ ιn τ ^i' in vD t— oo oo cn oo σi oo cn r- cn cΛ H CM co τ -τ ιn ιn vo vo vD cM CM CM Cθ H CM Co cM 'T '<tr VD vo r- ιn ro cM ro τ cM ro ^i' H H θ oo Φ W Φ Φ Φ Φ Φ Φ r- r- r- ^ ^-- r-- ^ ^ ^ ^ r' l^ t ^ ^■ ^ t~ ι^ ^ ^ t^ ^^• ^ r^» r-^• ^ r- r• r ^ ι r~ ι*- Φ

ω ^ ^ ^ ^ co oo os oo (o ol m Λ ⁽Λ Oi m m o o o o o o o o o o o o H H H H H H N (^l N (! (^ι (^ι N N c^ ι») (ll n f n ι») fl 'l' ^ ^ r- ^ ^ ^ r~ ^ ^ ^ ^ ^ ^ ^ ^ ι- r- ^ t-- ^ ω ω ∞ ω ω ω _ ω ω _ ffl „ » ω _ » „ „ » TO ω oo ω ω co co oo co ω o ω ω ω co co

CN CM CM CM CM CM CM CM CM CM CN CM CM CN CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN

E^H H H C C CO C C C CO CO CO C Cθ HH HH HH H3 J J H Ht, H3 , _ pH CH C CH θH pH CH pH rt

W « ω H H H H >H >H H H H H rt; rt: fiC rt! κt; fit; rt! >H >H H >H H >H H H >H 4 H ^ ω ω W ω

Σ Σ O θ HH HH H^ HH H^ > > > > > > > H H H H H EH H EH EH H H EH C C C C M C0 rt! rt; rt: rt! rt; rt; rt! C_ l_ι 0. C C« CM

H CM H H CM CM H CM fit! CQ CD rtJ CQ fit CQ CD O CQ Q PQ Q C_| Sl _: υ υ o z oooocozoυυozoooυυ ozoυoυoυoooυo A CQ CD fit! CQ CD Q Q z υ υ o υ o zυυυooυo z Q o A υ υ CQ C υD υ o rt! z o

H CM OO T in vo r— oo cΛ O H CM CO T in vD r— ∞ cΛ θ H CN ro τ m _> r— co cn o H CM ro ^ in vo r- co cn o H CM ro T in vo r- oo cn o H CM o '3^, Ln vD

CO CO <X⁾ CO CD CO CO CO CD CΛ CΛ CΛ Cn cn cn cΛ CΛ cn cn θ O O O O O O O O O ιH H H H H H H H H H CM CM CM CM CM CM C CM CM CM Cθ rθ rθ ro n O O O O O O O O O O O O O O O O O O O H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H ro ro ro ro ro n ro ro ro ro ro ro n ro co m ro ro ro ro ro ro ro co n ro ro n ro m ro ro ro m

00

ΣoΣΣoΣooΣoΣΣooΣΣoΣ O o ooΣoΣΣoΣooΣΣoΣoΣooΣΣooΣoΣΣooΣΣoΣoΣoΣoΣooΣΣoΣoΣoΣooΣΣoΣooΣΣoooΣΣoΣooΣoΣΣooΣΣoΣoΣooΣoΣΣoΣooΣoΣ o A A A A A A A A A A A ft A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A

Table 6

ATOM 3137 CB GLN 2284 67.964 21, .127 130. .542 1.00 25.05

ATOM 3138 CG GLN 2284 66.814 22, .065 130, .681 1.00 25.12

ATOM 3139 CD GLN 2284 67.292 23. .440 131. .000 1.00 25.68

ATOM 3140 OEl GLN 2284 67.992 24, .077 130, .202 1.00 27.13

ATOM 3141 NE2 GLN 2284 66.941 23, .914 132. .181 1.00 26.58

ATOM 3142 C GLN 2284 68.646 20, .052 132, .695 1.00 24.85

ATOM 3143 O GLN 2284 68.624 18, .881 132, .303 1.00 25.65

ATOM 3144 N PRO 2285 68.417 20, .373 133, .978 1.00 24.45

ATOM 3145 CD PRO 2285 68.537 21. .685 134, .637 1.00 24.26

ATOM 3146 CA PRO 2285 68.119 19. .336 134. .969 1.00 24.12

ATOM 3147 CB PRO 2285 68.541 19, .980 136, .271 1.00 23.75

ATOM 3148 CG PRO 2285 68.097 21. .378 136, .070 1.00 22.99

ATOM 3149 C PRO 2285 66.637 18, .990 134, .988 1.00 24.46

ATOM 3150 O PRO 2285 65.787 19, .759 134, .533 1.00 25.13

ATOM 3151 N HIS 2286 66.327 17. .823 135, .519 1.00 24.23

ATOM 3152 CA HIS 2286 64.946 17, .408 135, .620 1.00 24.03

ATOM 3153 CB HIS 2286 64.712 16, .157 134. .784 1.00 24.57

ATOM 3154 CG HIS 2286 63.319 15, ,629 134, .894 1.00 25.55

ATOM 3155 CD2 HIS 2286 62.275 15, ,690 134. .040 1.00 25.90

ATOM 3156 ND1 HIS 2286 62.853 14. ,997 136, .026 1.00 26.20

ATOM 3157 CEl HIS 2286 61.580 14, ,689 135, .863 1.00 26.25

ATOM 3158 NE2 HIS 2286 61.205 15. ,098 134, .664 1.00 26.27

ATOM 3159 C HIS 2286 64.615 17, ,158 137, .090 1.00 23.84

ATOM 3160 O HIS 2286 65.011 16, ,154 137, .673 1.00 22.43

ATOM 3161 N ILE 2287 63.896 18. ,097 137, .689 1.00 24.72

ATOM 3162 CA ILE 2287 63.541 18. ,003 139, .095 1.00 25.15

ATOM 3163 CB ILE 2287 63.338 19. ,400 139, ,682 1.00 24.12

ATOM 3164 CG2 ILE 2287 63.106 19. ,311 141, ,166 1.00 26.07

ATOM 3165 CGI ILE 2287 64.572 20. ,248 139, .411 1.00 22.78

ATOM 3166 CDl ILE 2287 64.445 21. ,660 139, .880 1.00 23.38

ATOM 3167 C ILE 2287 62.279 17. ,188 139. .289 1.00 26.72

ATOM 3168 O ILE 2287 61.423 17, .134 138, .404 1.00 28.94

ATOM 3169 N GLN 2288 62.159 16. ,560 140, .453 1.00 25.98

ATOM 3170 CA GLN 2288 60.998 15. ,742 140, .749 1.00 25.93

ATOM 3171 CB GLN 2288 61.194 14. ,364 140, .128 1.00 26.69

ATOM 3172 CG GLN 2288 59.997 13. ,458 140. .215 1.00 27.14

ATOM 3173 CD GLN 2288 60.212 12. .198 139, .411 1.00 27.36

ATOM 3174 OEl GLN 2288 59.344 11. ,777 138, .636 1.00 26.74

ATOM 3175 NE2 GLN 2288 61.376 11. ,587 139. .583 1.00 23.82

ATOM 3176 C GLN 2288 60.834 15. ,627 142, .252 1.00 25.36

ATOM 3177 O GLN 2288 61.803 15. ,376 142. .955 1.00 25.09

ATOM 3178 N TRP 2289 59.615 15. ,820 142. .750 1.00 25.01

ATOM 3179 CA TRP 2289 59.378 15. ,724 144, ,188 1.00 24.43

ATOM 3180 CB TRP 2289 58.474 16. ,848 144, .687 1.00 25.01

ATOM 3181 CG TRP 2289 59.160 18. ,185 144, .825 1.00 26.96

ATOM 3182 CD2 TRP 2289 59.838 18, ,695 145, .983 1.00 26.71

ATOM 3183 CE2 TRP 2289 60.271 20. .005 145, ,673 1.00 27.05

ATOM 3184 CE3 TRP 2289 60.118 18. ,173 147, .251 1.00 28.37

ATOM 3185 CDl TRP 2289 59.218 19. ,174 143, .888 1.00 28.38

ATOM 3186 NEl TRP 2289 59.880 20. ,273 144, .389 1.00 27.75

ATOM 3187 CZ2 TRP 2289 60.965 20, ,807 146. ,586 1.00 28.09

ATOM 3188 CZ3 TRP 2289 60.815 18. .975 148, .169 1.00 29.60

ATOM 3189 CH2 TRP 2289 61.228 20. .278 147, .828 1.00 29.72

ATOM 3190 C TRP 2289 58.772 14. ,389 144. ,567 1.00 24.28

ATOM 3191 O TRP 2289 57.858 13. .915 143, ,921 1.00 25.11

ATOM 3192 N LEU 2290 59.299 13. ,784 145, .623 1.00 24.33 r— ro -> in in ro m m m t— oo -. r- τ H cΛ ιn H oo i' ro oo σι _> C τ τι r— T H Vo oO H o ro r— ι ^■» H r— r- θ H oo ro cΛ τ VD ro cn cΛ H oo vo CM cn oo oo

<s V O r- VD OO m VO CM CO rH *'- o m oo ro cM co co _T co co ro cΛ co oo oo o o o vo oo oo vD CM ro cΛ r- co r- ro ι* ro ro cΛ m o ιn vo co r~ o CM o cn ro o o

© •S ω ^ ιn ιo ^ Φ m Φ ^ lfl v ^ Φ fl ^ <n H H ^ Φ ιn ιnΦ ^ι π ιn ^ ιn ιn ιn co m Λ H ιn <J co m N ^ ιn ιn ιn ^ ^ co fl^ O M n ^ o ol o _

CΛ .a

S CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM co ro ro ro m ro m ro ro ro ro n ro r^

E? oooooooooooooooooooooooooooooooooooooooooo

H o o oooooooooooo oooooooooooooooooooooooooooooooooooooooooo υ o o oooooooooooo

PM H H H H H H vo o oo co vo ro cΛ r— «3' θ CΛ in ιn τ eΛ cM θ τ cM r- ro o T vo r— ro oo cM O T t— ιn m ιn oo cM θ vo o vo ro cM co oo vo cM τ ro vo vθ H τ t— T Γ- CM

CXl CΛ _'T in rO 'T in VD rO in oO VO H 'T VD O CM in CΛ CM OO ^ T H H T O H '. OO OO t^ -Ϊ O^ H W OO rO r- H rO H VO H r- CO CM T OO '3' O rO CM VO O CM o ω _ ^ ιn n ω cvι (O ι co o N f Φ Ol ^ o m cι Φ o ^ ^ N oo ^ ι m _ ι n v H Ol c^ι n o ro ^■^^■ Φ N Cl to ιn Φ ctι ιn 'r H lO H vo ιn τ ro τ t— co r- cn e o H M to Λ oo o o H H O O CΛ O H M H H O H CΛ O CM C rO 'T in rO _'T ^ rO H H O T ' in vo o i in ^ t- t— oo en τ ^,^ τ 'τ ^,- --- 'T 'τ τ τ ιn ιn ι ι ^ ^ ι ι ιn ιn ιn ιn ^ ιn ιn ιn ιn ιn ιn ιn 'τ ι ιn ιn ιn ιn ι ιn ιn ιn ιn ι^

H H H H H H H H H HH H H H H H H H H H H H H HH H H H H H H H H H H H H H H H H H H H H H HH H HH HH H H H o ro T in t— vo o "3^, oo t— τ ιn<αι o τ ro o ^ ro ro τ r- <Λ VD σι oo cM oo o cM cn cM CD cn co H o co cM ι-ι vo vo ro t- ro vo <3ⁱ ro in r- r- cn r- o T eΛ CM «- in ro m H '- oo o m τ o τ r- '-^, t— o cΛ r- vo r- c CΛΛ VVDO T_ι iιnr* HH l _o> ecMM CcΛn mcn ccΛΛ rcoo rr—- CcMM CcOo mco rr—- ccΛΛ HH VVOθ ccθO HH iτai oo oO rr-- oo cn T T o0o0 H co t— oo r- t— t— r- in ro vo o vo oo oo oo o in cM H in t— vD CM in m o CD CM VD 00 in τ CΛ CΛ r- O 00 CM t- H O CΛ CM O 00 r- T 00 VO I— vD •o' ro t—

CM O H CΛ CM CO H H H H H H Cn en cΛ CΛ CXJ CO OO CΛ C— OO CΛ r- OO VO in in -T VO t— -T OO rO CM rO H CM O O H H O H H O H CM rO rO T O O H O I I I I I I I o τ ro τ θ ιn ro cn en (Λ cn τ ro τ o cM θo o cM H θ H co oo cM r- rH H CM CM o ro i' CM cn m oo cΛ o cΛ CΛ T oo H ro H ji oo in vo vo in ro m oo

OO CΛ H H CM m oO T O O H CM CΛ rO rO OO H Cn in t— O VD VO T OO ^- T VO t r—- rH o τ r- cθ H ^. t— vo m o oo m r— oo τ t- ιn r- t— r— ro T T T r oo oo o rθ H τ cn ιn H vo σι ^. τ ro τ H o ro vD oo ιn m ιn ιn cM oo oo r— t— tΛ CM ro ro VD r- ro cM in τ VD ^r o o H oo r— θ H <Λ t- 00 H τ ιn oo σι o θ H oo co t- r- ιn τ m ^ι τ (— r- oo oo cn o H H CM CM r- vo vo ιn ^ rθ 'T M vo t- ιn ιn ιn τ ι ^ ro ro cM τ ro cM co r 'τ r H r '3' in ιn vo in in Φ Φ -i in in in in in in in in in in in in in Φ Φ Φ Φ Φ in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in

o o o o o o o H H H H H H H H H CM C CM C CM C C CM C C ro ro r ro r ^ ^ ^ ^ ^ in i i i i in i vo vo o vo vo o v^

CΛ CΛ CΛ CΛ Cn Cn cΛ Cn CΛ CΛ CΛ CΛ CΛ cΛ CΛ cΛ CΛ cΛ CΛ CΛ CΛ cΛ CΛ CΛ CΛ Cn cn cΛ CΛ CΛ CΛ Cn cn CΛ CΛ CΛ CΛ CΛ Cn Cn cn C^

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM tM CM CM l M

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

D D D D D D D co co co co co co co co ω co co co co co ω co co co ω cd ω ω t-i ω t-l W (-I D D D D D _{HH H H HH HH H H} Z Z Z Z Z Z Z Z H >H

W W I_l W U W W H >^{H H} H H >H H ^H >H H H H H rH H H H H H HH rH rH t_l HH HH H-) HH HH Hl H^ H^ HH rt; rt! fit! κC fit fit; rt; <o co c c co cn co co ^ H-i HH HH HH HH HH HH HH HH HH J HJ rJ r-H rJ HH HH B K ffi a aC aC aC tπ BC aC H H H H H I-H H H θ o o o > > > > > > > rt! rt; rt; rt; ri! fit; rt; rt; cD

A rO T in vo r- oo σ-i O H CM oo T m vo r— oo eΛ O H CM CO T in co r- oo <Λ θ H CM ro τ m vo r- oo cΛ θ H CM Co τ ιn vD r— co σϊ O H CM CO '. m vo r- oo

CΛ CΛ CΛ CΛ Cri lΛ lΛ O O O O O O O O O O H H H H H H H H H H CM CM CN CM CM CM CM CM CM CM CO rO rO rO rO rO rO rO rO rO T T T T T T T 'T T H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CN CM CM CM CM CM ro ro ro ro ro ro ro ro n ro ro ro ro co ro ro ro ro ro ro ro ro ro ro ro ro ro n ro ro ro ro ro

00 rH rH ΣoΣΣΣΣoΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ

© o H EHoEHoHoH HoEHoEHoEHoHoEHoHoEHoHoEHoHoHoHoHoHoHoHoEHoHoHoHoHoHoEHoEHoHoEHoHoHoEHoEHoHoEHoHoHoHoHoHoHoHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoEH o A < ft A A A ft A A A A A A A A A A A A A A A A A A A A A A A A A A A A ft A A A A f ft A A A ft A A A A A A A A A A i*

ro o <Λ o in r- co H r- Λ CO t— H CO O H t— CO VO CM in CO t— CM Cn τ CD H O 00 in cΛ Vθ vD H in ιn r- τ t— CM cn ^r oo vo vO '3^, cn t— cn ro CM o oo

JS - H «- -=. ιn m H [— r- oo τ r- vo ιn m H VD oo ιn oo τ vo σι ro r- ιn cM rH vo r- VD in H CO H ro cΛ vo r- vo cΛ co in rO T O vo o cM Vo ro H r-

© © § cΛ o r- in in co -gi ro cM H H CM ro T r o c oo f- m T T ro i— r- r- r- r- vD vo vo in in in ^ T -p ro T in vo vo ro oo ro ro oo cM oo cM cO 'T ro cM ro ro

CΛ •H m vo ιn ιn ιn m m Ln ιn ιn m ιn ιn ιn ιn ιn τ τ '3^| τ τ τ '3i ^3* ^* ^* KI* ^* ^* ^* '■S* ^* ^* ^3* ^* ^* ^* _*3* Kj* ^* 'T KI* ^J* ^f ^* Kf ^3* KI* ^3* ^3* ^3* '•ΪS' ^* Kf K ^3*

5 H OOOOOOOOOO o o oooooooooooooooooo ooooooooooooo o o o o o o o o o o o o υ OOOOOOOOOO o o ooooooooooooooooooooooooooooooo o o o o o o o o o o o o

PM HHHHHHHH

C0 CD C0 00 H H O H CM r- m C000 CM V0 τ m θ f- V0 O O f- O r- T in r- oo cΛ oo cΛ r- oo m o r- oo cΛ cM t— t— vD oo in vo T T CM in cM r- vo cΛ vo

_> ro cM _> m ro _> m t— cM cn m oo ro cM CΛ co r- m H CM H H ro cM θ cΛ H o m rθ '3' θθ H in o r- m in vD o co cM r- ^ oo ro in T oo ro H O in vo

H m CΛ CD O -T CΛ rO OO O r- CΛ CD H H r- CO r- VO H CΛ OO Cn o t- f- Cn t— CΛ CM O CΛ H CΛ H CM rO O CM CM T O T OO H O rO T H VD r- CM OO rO H ro co Φ ιn ln ^ ι' ^ ^ f ^ 1 Φ β <Λ ( H N H (v! O cvl H H H (Λ a) co (JO ^(! co ^ ^ ^ ^ ιn '» ^ ι») ιn ιn ^ oo ω Λ O Ol ^ ^ ιn ^•if ιn ιn ιn ιn ιn ιn ι ιn ιn ιn ιn ι ιn ιn ιn ιn ιn ιn ιn ιn cn ιn ιn ι ιn τ τ 'T 'τ τ τ '<3^, 'T 'T ^, ^ ^ 'τ τ τ '. 'w

H_{H H}HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ιn ιn vo o H τ cn t ro ro cn ιn α3 in σι cM 'τ o σ^ ιn oo oo 'τ oo r (η co t- H in vo oo ro Pθ rH CΛ in 'τ ro vo o ro τ vo r- τ

^ H * o ιΛ ^ (D O ^ ^ H ιn ιΛ n ^ ( <ι^| H J N N oo ιo ι!l m n ιn ι fl o o (Λ H H ω co H ιn » ιn ol ^ ιn ιn ιn Φ ιn o o ιJ^ ι») 5l Ol ιη o

CO in CM rO VO -T H H in VO r— r r in τ CM O O VO H VO O H r- in r- OO O O H "3^, H (X) CM OO CM θ rθ H '3ⁱ OO H CD <Λ H t— T OO OO CO O H H OO H

O O H CM CM O O O H CM rO T T in H CM o o H H O H H CM rH τ m m vo r- vD vD vo ιn m τ ro cM CM ro ro ro ro ro ro CM H H H O O O I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I

H VO O H o ro vo m t— O O H H T O T H OO OO H VO VO O m r- in t— o oo oo oo co m in ro o t— I' ^r H CΛ r— t— VO T OO VD VD ^I^I O ΓO CΛ CM O OO CM VD CM H CO H c VD H in N r- CM cn cn T r— m in cM cn cn H vo m H T C T CΛ ^i cn oo t— r- τ ro «3^, vo H cn H in cn o ro in t— ro r- oo t— OO H r— oo T i-H oo T ro in r— τ vo ro ιn H '-r r— ∞ in cn t— r— cn t— CM r- o eΛ H CM oo cn cn vo cM CM CM τ θ H θo r- τ T ΓO CM Γ— in H Vo co rO H o m in

^ m ^ o) ω ^ oo ^ (s m o ol o ol o o o o H N n 1 (η o o o o o N O oo o (^ lI! N ( N ( (O N H H ^ ln 9 ιrι ^i) r• - (O ln ι£ι ^f 1» (<) ^ι' in in in in m in in in m in Φ in Φ tn Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ in Φ in in Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ

I— r- rø ∞ ∞ ∞ ∞ ∞ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ O O © O O O O O H H H H CM CM CM CM CM CM CM rθ ro rθ rθ rθ r .^ r T CΛ CΛ eΛ CΛ cΛ CΛ CΛ CΛ CΛ en cΛ Cn cn cΛ CΛ Cn cΛ O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O

CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro m ro ro m

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

^ ^ prj pή o- CH PH CH Co co co c co c OT co c pQ ω ω w ω w ω ω ^ ϊH ϊH ^ O O O O O O O CU CM CH CH CM C-I C-I PH Z Z Z Z Z Z Z Z D D D D

H-l HH ω ω td ω ω td ^ ^ ^ ^ ^ ^ ^ ^ H^ HH HH HH H H^ HH HH HH Hq HH HH _^ ρ--,, oi i pH pH Pi to c co co c t c c c w OT c w w ω co ω ω ω r-i O O CO C_ W C CO W h-l H3 l-l HJ l-H HH HP HH HH l-H H H H H H H H O O O O OH Q n4. c c_ c c fit fit fi( fit: fit fit; fit < rt! rt; fiC ιQ rt; rt: rt: ₁-i HH H5 HH

CM H H H CM H CM

A CQ CD A CQ CD Q ω I υ o z υ υ o υ o fit CQ O CD Q fit Q υυυoozυoz fit CQ CD A CQ Q Q fit CQ o Q Q et CQ o o υ υ o o z υ o o z υ υ υ o o o z υ υ υ o O υ o z υ υ υ o Z υ o z υ υ υ vD r- oo cn o H CM ro T m vo r- oo cΛ O H CM rO _'-, _ ω ω co cft m Λ n cΛ CΛ CΛ <Λ Λ rι o o o o o CM CM C

oΣ∑Σ∑ΣΣΣ∑∑∑ΣΣΣΣΣΣΣΣΣ EHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoEHoEH rt; fi rt; rt; rt; fiC

rt r- ro o ro vD H CM r- cΛ cM ro ro ro H in co •- o m vo vo m r- o vo H <Λ ro o ro cΛ co ro ιn co (Λ CΛ θ vD σι (M oo cΛ cΛ H H cn cn ro vo m in cΛ oo oo rs oo oo oo cΛ cri ro in ro r- ro ro ro CΛ ro in o ro cn oo in en vo o o c o r- σi o i 'i- D r- r c Vo cM r- ci cΛ o cΛ CΛ vo o H CM oo o ro m cM r- o © .a oo T crl Λ co β ω ^ ^ Φ 'l^| ^ v Φ Φ u1 Φ (0 ( N ^ι c! f O H C^l H O H ^ r- <Il m (n o ^ Φ ^ ( v ι Φ ^ ι ι' ( ιn N ιn ιn

CΛ T T M oo n ro oo ro ro ro ro ro oo n n ro ro ro ro ro ro ro n ro oo M ro ro ro ro ro ro ro ro ro c ro cM CM CM CM CM C^

H oooooooooooo ooooooooooooo ooooooooooooooooooooooooooooo oooooooooooo ooooooooooooo ooooooooooooooooooooooooooooo PM rH rH rH rH rH rH rH rH rH

CΛ CO CO I— VD T T VD r- τ r- 0O T VD τ CΛ θ r- cM in vD CM co o cΛ CΛ m τ CM co vo o H CM ro vD T O CΛ CM '. oo c- ^j' ro ro oo in oo vo in H o o cM in cM ^ r- vo co in cM OO H oo oo oo oo vD o CM H t— CΛ t— CΛ Cn cO H O OO CΛ VD T in oO H o r- ro H ro oo cM rH oo ro cM OO CΛ in oo oo H in in cΛ O 'sr ro o t— oo oo oo t— H oo H CΛ co ro cM in oo vo cΛ H ^r cM CM θ cn ro oo θ H τ ro vo vo H CM CM CΛ cn ιn ιn oo oo ιn o t- H θ τ ι- H θ ιn m r- vo H

T T t— oo t- r- oo σi t— oo vo co co cn cn o H oo oo o o oo cn r- co vo r- ιn vD ιn vo m vo vD r- oo vo >-ι^ι m oo cM H θ H H ro ro ro oo ιn vD t— VO CM CM CM

*^* ^* ^3* ^3* *^* Kf Kf Kf Kf Kf Kf κ|* '•'3* ^3* ^* t. ^ Kf *^* ^ ^ ^* ^* f **** ^3* ^* K ^3* ^* f K ^* Kf ^3* ^3* ^* * ^3* ^* K Kf ^3* ^* KJ* ^»* ^* ^3* Kf ^* ^* Kf ^3* ^* Kf H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

T 00 CO VD CM rH cΛ oo cM cn vo ro cM τ τ oo τ r- vo τ ιn τ vo H r- co ro ^•.. < _Λ O (— H CΛ «3^l 00 CM CΛ CM in ^r 00 V0 t- CΛ CΛ V0 CM 00 H en VD in CD 00 CD O — oo ' coΛ — r- ^i o 00 co ro o oo oo '- VD o cM in o o t— H in vD ro o ro oo in c CΛΛ T^βi tr—- O VO CΛ OO CM H CΛ CM O CO T in T CM in H in H O OO H H in ^ⁱ m eM co ro r- O H O (- O T CΛ τ V0 00 00 00 00 O H T (Λ CM r0 O CΛ C0 CΛ O H r- CΛ O m OO CM r- H r- OO OO t— Cn VO OO T T O t— CM CO OO OO in H T H VO

O H O O CM O CM '3' T CM OO CM CM CM O O H O H 00 m τ vo vo r- vo vo m oo oo oo cn cΛ cΛ o cn o en o o H en en cM H oO "- T ro T ro in vo in I I I H H H H H H H

«. H co m tΛ VD o τ t- oo t— m o in cM in oo oo o w ^ ^- ^ii '. cM co ro vo cΛ CM CM CΛ co o cM H r- r- in oo in Λ oo cΛ oo o i— CM ^- t- CM CM H VD in o cM CM oo ιn ^ι> oo r- ro o cM ro oo cM oo o oo m ro m cM cΛ vo τ -r- cΛ co cΛ in vo cΛ m r- T CΛ H in H ro co cD r- oo ro r- in vo H O O Γ- CM T VD Γ- O oo oo o cM cn cn cn vo ro vo m m H H H vD in r- r- H H cΛ o r- ιn r- cn H oo r- cn oo t— τ τ ^ι r- ro r- C D vD H in oo co τ H CM m m O CM CM CM T ιn « t ^ι c^ι n H N M O o m ()3 ^ ^ ^ ^ Φ Φ ^ ^ eo ^ co Λ m ιn ι ^ n N H H O ιn ιn ιn ιn ι Φ ^o ^ ^ ( ιn 'l^ι '» ^•<^ ιn n '» r ι Φ Φ ω Φ Φ Φ Φ Φ Φ Φ Φ m in in in m in m in in in in iii in in in in in in in in in in m in in in in in in in in in iΛ in in in in in in in in in in in in

l ιn ι ln Φ Φ Φ Φ Φ r1 π ι-ι

O OOOOOOO O OO H H H ro ro co co co ro ro oo ro ro co

CM CM CM CM CM CM CM CM CM CM CM

D D D D O O O o o o o cH H OH O- pH DH pH H C- pH H - J J ^ H iJ H H z z z z z z z w ω ω ω ω w w ω __> D D D D D CO a W lU a tX tX CU CU X C X X X A e A A rl r rl rl rl r r rl r rl r r r^

H π^ ι-H H-I Cu CU H a C C-ι EH EH EH EH EH EH EH EH EH EH EH H > > > > > > CD C O ) O CD CD H H H H HH Ha HH HH HH HH HH HH HH

H CM H H CM CM H CM H CM CM H H H CM

Q Q Q fit CQ CD fit CQ CD Q U Q W N CC υυυozυooυυozoυυυoυυooυoz fit CQ O CD A cQ CD a ω ω fit CQ CD CD Q fit CQ O Q Q O O O O O O z υ υ υ υ o z υ o z υυooυυozoυoυ.υυo rO T in vo t— oo en o H CM rO T in vo t— oo cn o H CM ro τ ιn vD r- oo <Λ θ H CM Co τ m vo r- oo tΛ o ( N ( N N N N tn ι ι ιη t (θ n fl n n >ι^ι ^ ι» i)' ^ ^ 7 <r ι» ^ ιn ιn ιθ ι ιn ιn ιn ιn ιn ιn - oo co oo oo rπ ro ro n n ro ro ro n ro ro M ro ro c oo oo ro ro ro ro ro ro ro ro n ro ro ro ro ro n ΣooΣoΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ EH EH EHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoEHoHoEH EoHoHoEHoEHoEHoHoEHoHoEHoEHoEHoHoEHoEHoEH rt; fit rt; rt; fit fit rt! rt! rt! rt! fid fi rt! fit rt; rt! fiC ι< fi fi

rt t- ro vo τ H in <Λ ro ιn m co ιn ι— t— "sr o o m oo o oo cΛ r- t— o CΛ cn T t— θ r- C0 r0 O rH in τ CM 00 H CM r- O H 00 H '3^, O O Cn o θ CM 00 H ro o

<s - eΛ CN in τ m ro m o vo cM τ τ oo ιn o cM oo cΛ ro in ^•. rH in cΛ CM CΛ H oo o cn cΛ CM VD oo tr vo cΛ cM T ro H co co co o en o ro en oo

"•3 o ■Q

© in vO r- r- VD VO VD [- Vθ r- m vθ T OO (Λ CΛ O H H CM H H CM CM CM OO CM VO H ^I' '. VO r- H T VO T t- CO in τ T T VD O rθ H O CΛ VO H CΛ eΛ CO CO ιn

,β

CΛ cM CM CM CM CM CM CM CM CM CM i CM CM CM CM CM ro ro ro ro co oo ro oo ro ro ro r oo oo oo ro ro T T T T ro ro ro ro oo ro ro ro ro ro oo cM CM co cM CM CM CM CM

OOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOO oooooooooooooooooooo

H OOOOOOOOOOOOOO oooooooooooooooooooooo oooooooooooooooooooo υ

PM rH rH H rH rH rH rH rH rH t— oo ιn ιn ro o o ιn r- (— CM T r- CD CO T Vo t— ιn vD τ τ H CΛ oo cM θ '- ro ro o T OO oo cM oo vo in T CM o m σ^ co o ro H oo cM CM ro ro T OO t- ro oO '-i o o o cn H VD CM CΛ H co o H O rH o ro oo ro vo in r- o o vo vo T vo o T O OO T VD VD OO CM H VO CM H CΛ ro eo r— t— CM vo cn cΛ H co cΛ CΛ ro t— oo oo o vo r— ro m αo in cn vo t- t— O O in CM O CM CM H VO O H VO CM in rO rH T VO CM CM VD

H H CM H OO r- r- r- VD VO VO VO m in T T O CM rH CM O CΛ OO r- r- O O rH CM CM H H θ oo τ τ m vo vo r- m ιn τ τ oo cM θ m vo m vo ιn **3ⁱ T T T T T T oo ro ro ro ro ro ro ro ro ro ro oo oo oo ro ro ro cM CM CM CM ro ro ro ro ro ro ro oo ro oo ro ro ro ro ro oo co ro ro ro oo oo ro oo oo ro ro

•» c^ (o eo ιη <J o Φ o ^ o ^ ^ ^ ^ o (l ln ffi H ^ v ιn ιn fl ( ι ^O Φ ■J (^ι ^n Φ 'l^| cD Φ ιO IO Φ H lrι H β Φ 9ι H ιn cD ι^ι N Φ H ln ^ H vo c_ι o ιn vo cM in H ro cM iΛ CM ^ CM ro' o ιn cM τ cM in ιn vD vo ιn ιn cM CM H in ιn H H τ oo Ln ro cn cM rθ H vo vD vo τ cM vθ 'T H in H oo

^ (Λ N v ^ ^ m ^ ^ c1 o m o o1 (D oo o <^ N ^ H (l N o o ln ιn « ^ ι 'l^ι ^ 'l' co ^tι ^o ι»l (n H lo ι ι ιo o H 9 'l' O ι^,l o o fl n 9 ^o r- vo r- cn o H CM VD in vo vo in T t- t- t- CD Cn oO r- CΛ CΛ O H O H O H O H CM O O Cn oO r- CΛ H H H H O CΛ H CM rH CO T in in VO T T T T T

H CM CM CM H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM rH H H H CM CM CM CM CM H CM CM CM CM CM CM CM CM CM CM CM CM CM

CM OO O r- rH CM H CM Cn i— CΛ CO CM VO H H H CM VD O O VD O o ro cM cn co cΛ co t— vo o oo co cM CM r- CM r- o cD co co τ vo r- ιn cΛ r- o oo ro o o cM O O T CO t- CM r- oo o o ro H r- CM in H in H t- co co co ro τ ιn vo cM θ oo cΛ ιn ro cM ro co H θ oo t- ro vθ H in τ cΛ ro o H m cΛ t— vo oo H t— t— m in o eΛ H t— t— cn vo oo oo oo in in H o oo o m H in H ro ^i cn o co H ro cM ro vo ro vo vo in o oo oo cM in m in m m Ln vo t— vo t— r- in oo t— vo oo cn o co oo oo oo r- vo vo m ιn ^ι^, vo τ τ τ cM CM H H H eo cM τ τ m ro ιn vo r- co r- t— vo oo oo oo cn o cM in in in in in in in in in in in in in in in in in Φ in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in Λ in Φ Φ

CM CM CM CM CM CM CM CM ro co ro ro ro ro ro T T T 'T T in in in in vo vo vo vo vo vo vo r- t— r- r- t— r- r- i— OO OO OO CO CO OO CΛ CΛ CΛ CΛ CΛ CΛ CΛ O O O i— i i—i . i— .... . i . i— i . r-i . r.-i. i— . . i r-i . i— . . ■ C CM CM ro ro ro oo ro ro ro oo oo oo ro ro oo ro ro n ro ro ro m ro ro ro ro ro n ro ro ro ro ro n co M

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ co co co co co cn co co os pS rt i-S pή oS oi fit Z Z Z Z , z z z , z oS oS os pc. ώ βS ctf cϊ. αl αϊ eή β. aJ fx. α. c-i CLi < ^{H H H} :>^H >^{H H} < K K _{K M a} ^H _{;:C :}_, .-, c CO CO C ωC CO cCO wCO K S S J- X K i- as iii a B s a K t ω c rt! rt; rt; e rt; ι fit fit EH EH εH EH EH H EH EH EH EH EH EH EH EH fi fi fit

H CM H CM H CM H CM H CM f CQ CD Q SI A CQ CD CD A CQ A fit C CD A CQ O CD fit C f o o υ υ o z o o z o υ o υ υ O z υ o o o z oυozυυQ CυDυυo fit CQ CD D Q i z ooυ o zυo z o o o υ υ o zooQ CoD CoDoozot CυQ ιn - H H

ΣoΣo A ft

rt t- ro r- O r- H en r- vo o cΛ ro o oo vo m τ vo o o co T T C- OO CM VO VD H VO OO OO O m co r- in in cΛ r- cΛ vo m oo o oo o ro oo in cΛ o oo vo o cM r- JS T CO M O 00 T H VD OO O CΛ CΛ H rO VO O OO CO CM H '.' in oo H ro t- r- '- O CM ro m in m o ^Λ CM. ⁱ m^{fi M} CM ^HHj ^ i i o ^ ^ H H in V in Ol O H IM

© o •--r cM cM H CM ro m vD o oo ro o vD t— vD oo o cM in vD in t— t— i— ιo m τ oo τ vo ιn ι— co o CM ro T H co t— r- r- t- oo oo r- oo r- vo τ oo o H [— co oo

CΛ δ CM CM CM co ro ro ro rO T T T T oo co ro ro T T T T T ro ro ro ro ro ro ro ro ro ro ro rO T T T T T oo ro ro ro ro ro ro oo oo ro ro ro ro oo ro oo ro ro oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

H oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

PM H H H H H H H H H H H H H H H H H H H HH H H H H H H HHH H H H H H H HH H H H H HH H H H H H H H H H H H H θ H m τ H r- vo oo m ιn vD cΛ vo cM ro cM VD CD ιn oo ro τ o H ro o oo ^ H in vo oo r- oo r-* o ^- i vD c ^i' oo r cM r- rH H VD vo vo cM rH T i '-

CΛ 00 CM VO CO CΛ |— m in cn t- ro T OO ^r co r- H vo co cΛ t— o in OO H Mi O VO in CM VO CM CM O in OO H VD H OO in O CΛ T T T OO rO CΛ H OO rO r- CM VD 0O CM CΛ H CM VD T t- CM in o cM oo oo oo o oo m cM cn ro vo t- o in - ^i" ro o r- r- τ θ CM θ cn co vo o ιn vo ιn r- o oo o r- oo t- eΛ ro ιn H cn σi H m

T in oo r- oo cD t- co in ^i' ro cM co cΛ co o cn oo oo oo t— o <-H o o cn co en cn cM CM ro rθ H H H CM τ ιn τ ιn vD τ r- ιn τ vo vo t- t— vo t— t— CΛ Γ- oo ro ro ro ro ro ro ro oo oo oo ro ro ro ro T oo oo ro oo oO T T T T ro ro ro ro ^3* ^3* Kf Kf Kf ^* ^* *_** Kf Kf ^* Kf Kf Kf Kf ^3* Kf Kf Kf ^* Kl' ^3* ^* Kf Kf Kf

H H H H H H HH H HH H H H H H H H H H H H HHH H HH H H H H H H H H H H H H H H H H H H H H

CM T t— r- r- r T OO CM VD VD CM CM rO VO OO OO CM r— r- cM in <Λ τ τ t— cn vo o o ro H fo o m cD cn ro ro cΛ oo in t- σi co o cΛ oo m H CΛ oo ^i' H oo cn VO in CM in i— CM CO CM Cn cΛ VO OO '3' CM rH OO H m 1— co oo oo σι r- ιn oo oo H oo θ rH t-H Co m oo oo co co in H o vD oo o in cM T co H t- ro in vo cM in co

T OO in oo cn r- oo vD vo oo o oo ^J' CΛ in o oo cM H ro cn r- cM CM O ro vo in cM CM CM τ m t~ τ τ VD o vD co m m rΛ '<_ o vD vo r- co τ eo H θ ro m τ oo cM ro in in co t— oo oo cΛ cn cΛ r— r- co vD in ιn ιn τ ιn τ τ τ co cM H θ CΛ oo cM τ τ ιn ιn vθ [— vo τ ^ -. τ ιn co vo oo oo cM rH O Λ CΛ 00 CM CM CM

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H CM CM CM CM CM CM CM CM CM CM CM CM CM C^ CM rH H H CM CM CM

_N Λ Φ

CM

Φ

© o o o o H H H H H H H H H CM CM CM CM CM CM CM θM CM ro ro ro ro ro oo oo ro τ τ τ τ τ τ τ *^ τ ιn ιn ιn ιn ιn ιn ιn vo vo vo vo ιo co vo ιo r-

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM N oo m ro oo oo oo oo ro ro ro ro ro oo oo oo oo oo oo oo oo oo ro ro ro ro n ro ro n oo ro n m ro r oo c n oo m ro ro

CM CM CM CM CN CM CM CM CN CM CM CM CM CM CM Cvl CM CM CM CM CM CM CM CM CM CM CM CM CN CM e^ l- ⁽- 0ι Oι ⁽. tll W 01 Ol w n θi ω n D D D D D D D D D B tH H H t< H B H D D D D D D D D D J ι

W tn W W Cn X X X l rl rl rl r r r rl rl ω ω ω W ω Ui a ω r r r r rl r rl A A Rt fit fi fi fi ω ω ω ω ω ω ω ω H fit Kt fiC rt! fit ₁-H HH HH H^ HH HH HH HH H^ O O O CD CD CD Σ Σ Σ Σ Σ Σ Σ Σ CD CD CD CD O O O CD O > > > > > > > HH HH- HH HH HH rH HH .-l .i:

H CM H CM H CM H CM CD Q Q et CQ CD Q W i fit CQ CD Q ω co fi co o Q ω fit CQ CD Q W Cd fi O O O υozυυυυυzυoz rti CQ C O O O O O O O z o o υ co υ o o z υ υ υ υ o o υ oz υtoOQ OoCoDoozυoυDoQoDυoz

ro T VO CΛ 00 "5T CM H VO CO H T CM H O OO r- CM Vθ ιn τ t— H oo oo ιn o cM τ oo <Λ r- t— t— ro H cn O O CΛ in OO T rO VD H T t— CM OO t- CΛ CO O in OO S 00 rH O CΛ f- vo o i-H ro cΛ co r- ro cM m o ro ro rM rH o cM ∞ cΛ o o ∞ CM in cM CM r- in vo r- cΛ H H T in cM vo ro vo oo r- o t- oo cM O r- o co oo vo

© o o ro CM ro ro <f α) (o ^ * ^ ln Φ ^ fll O H H l Hrl ιn ι!1 ^l f^ n ιn ιn ιrl fl n t! N 'f Φ ιnιn ^ N Φ ^ r-• (o o t 'f (») ^Clφ Φ oo ^ ^ T oo r r r r r o ro ro rO 'T T T T T T T T in in in T 'T T T T T 'T 'T ^ 'T T T 'T 'T T T T t H oooooooooooooooooooooooooooooooooooooooooooooooooooooooo υ oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

PM

VD H CM O CM t- CΛ CD r- o cM T in ro cΛ in cΛ r- oo o cΛ H i— cM vo t— in t- vo ro T vo T oo oo oo co oo H T O CM vo cΛ co m t— σi O T ^r co i r- oi c

VD '-. T OO m H CM H CD 'tJi H oo ro oo o cM oo oo oo in vD O T Vo r- r- ro cM r- r- H vD vo r- T H r- t— ro oo o H in oo vD ro cM r- cn co oo co vD vo o co

T t- rO H CM VO OO O CM OO O O m vo eΛ t- t- H t- vo r- vD co cΛ vo co cM -n cM CΛ CΛ CM OO CΛ CM CM CO CM H rO H CO O CD H CM VD VD OO CΛ H CM O H O OO

OO C- r- VO CO r- VO σi OO O H CM H CM O H CM rH H O CM C CMM OOOO ^ T in VD VO in ^ in VO VD in OO t— t— t— OO t- VO OO CO CΛ O H CM OO CM '- 'T in CΛ CΛ CO VD

T T T '. i' T T _'sr _'^' in in in i m in m in in in in in in in m m m m m in m in in in in m m in in in in in in in in vo vo vo vo vo vo vo vo in in in in m ro CM H co v voD rθoo mιn ττ θo cv _oo cc_Λrι. Cc_Λn. θo_ HH. . cσ_n-ι. cc.oo. cc_Λι. ιι_nn. oc.oo. ι_ιnπ. Tτ . Co -Λι oo.oo. oooo vv _oD tt-— r roo rroo min _. oo_.oo_. rr_.-— r roo _. o o_.oo_. c cΛn C CMM m m c cnn r r-— v wD o PoI m in πro oo c mM C IM H H H r r-— voU o ooo t r—— t r-— ui vj_ t— vo T o CM OoOo TT OoOo Γt—- ccMM <<ΛΛ oooo vvoo mm ιιnn ττ ccMM iinn rr—— oo imn iminn rrrooo vvoo σσii oooo oo vvoo T -- oo —oo cc -MM^■ ^^' cc -rrvv iinn- v-voo- rr--- oo —oo rr —ΛΛ HH . iinn- oo_ m^.m_ cc-MM. t_t—— HH TT ^.. i ^.inn_ vvOO HH CCMM ccnn eenn ccMM H in co CΛ CΛ CM r— CM CM CΛ oo o r- vD cn cΛ in r- ^r o T H r- oO H o T T o cn o o o en co oo oo T t- CM T in t— ro in m t— co cn ιn oo o cM ro <Λ τ r- cn

CM OO in in VO t- VO H H H O lΛ OO OO r- H CM H CM CM H O CM H H H CΛ CM O CΛ CΛ 0000 CΛ Cn r- ∞ VO m 'T 'T T T OO CM H CM rH OO CM T rO H H H O CM CM CM CM CM CM CM CM CM CM CM H H H H CM CM CM CM CM CM CM CM CM CM CM H CM CM rH rH rH rH rH r

CM in vO T OO OO H CΛ OO T H OO CM in r- CM CO CΛ CM VO OO CΛ r- H CM T t— H V0 00 00 C0 in r- V0 O 00 H r- T V0 τ r— T CO OO T H in CM T T CM rO CΛ O c

H cn vo vo cn vo cM VD LO T VO H O cn m vD cn vo m H r- ro cn m m co oo o t— vo ro cM O VD vo cM cn cΛ co oo H o cn cn m cΛ CΛ cM t— oo oo H ro ιn τ ιn H H oo cM H r- oo cM VD CM τ ro τ cM r— oo m H O H CM O oo H VO oo r— cM in oo r- ro i— τ ιn ιn ιn oo cM H r— ro ro cn cΛ CM τ r- τ cΛ VD θ m vo r— H

OO CM CM C O rO rO CM H CM H CM CO 'S' CM O O CΛ CD r- r- I— vo vD τ ro ro oo vD in r- c» cn o cn r- cD r- r- vD vo oo <Λ (— OO OO ∞ Cn cO OO OO OO CΛ O OO CΛ in in in in in in in in in ui in in in in in i in T T T T T ^ T T T T T T T in T T T T T T T ^ T 'T 'T T T 'T T in T

^ ^ ^ ^ ^ ^ ^ ^ oo (D oι o) oo (o ι. ω (Il lll (⁾l <^ (^ o o o o o o o o H H H H H H H N N N l ( ^ι ^l ιη (^|) (<l (<) f^ n p) (^fι n (^,l 'l' <ι'

C CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CO m rO rO OO r ro OO n oO OO OO rO r^

M oo ro ro m ro ro ro ro ro m ro oo n oo oo oo oo n ro m ro ro ro oo co ro ro ro n ro eo oo oo oo oo oo oo oo oo n

CN CM CM CM CM C CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ M OT ry) M W OT W m r/) D D D D D D D D O O O O Z Z Z Z Z Z Z Z HP HH i-3 HH HH HH H3 « iH H H H H H H H HH ω ω w i-i ω ω t-i ω oH CH θ, c» θH co c c co co c M c «q fi fJ! fit rt! rt; rt^ χ x x x x x x A ri r ri r r rl ft < < A A A A A A > > > > > > > w ∞ <n ∞ w w tb C c Ch Ch θH to c ch to ϋ ϋ

CM H H CM H CM H CM H CM H CM rH CM fit CQ CD ^{Q Q} ω ω ft CQ CD Q Q fit CQ ft Q a a fit CQ CD CD < CQ o fit m c O. a t-1 1-H ) ft υ oυ υ z o z υ o z υ oo υ υ υ o z υ oo o υ o υ o z o o o υ υ υ υ z o o o o o o υ υ υo oo υ oo zυ rO T in vD r- oo eΛ O H CM oo T in vo r- oo cΛ O H CM ro T tn co f- oo cΛ θ H CM ro τ m vo t- oo σ> θ H CM ro τ ιn vo ι— oo cΛ θ H (M θ τ m vo r- oo r- r- r- t— r— t— I CD CD CD OD CD CO CO CO OO OO CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ O O O O O O O O O O H H H H H H H H H H CM CM CM CM CM CM CM CM CM T -T T T T T T T T T T T T T T -T T T ^ ^ ^ T in in in in i in in in i in i in i i in in in in in in in in in in in in in in in M co ro ro ro ro ro ro ro oo oo ro ro ro ro ro oo oo oo oo ro ro oo ro ro ro oo oo oo ro ro oo ro ro ro oo oo oo oo ro r^

00 rH rH ΣΣΣ

© oooΣoΣoΣoΣoΣooΣoΣΣooΣoΣoΣ ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ

EH EH EH EH H EH EH H EH EH EH EH EH EHoΣ Σ HoΣ EHoΣ EHoEHoEHoEHoEHoEHoHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEH o A A A A A A A A A A A A A A A A A A A A A A A A A A A A A f£ ft A A A A A A A fZ fZ f di ft A A A A A A A A^ f£ A. A A A

t- ro oo o CM r- in CΛ cn T i— CM T H VO <Λ O ^- r- CΛ CΛ VD Oθ r- VO O H O O VD H H VD CM r- o r- H in in r- oo r- o CM co r- vo o H T r- oo s en m H oo r- r- oo oo T m vo vo vo r- cΛ CD Oo vo vo vO 'a' VD co r- o o m r- O VO CΛ CM CΛ *-3> T ιn oo vo r- oo in ro <Λ en oo co oo co o o o

© © co ro t— oo r- ^•» CN H CM CM o co cn co r- ιn ιn τ ^, cN ι-ι o o <Λ CΛ cΛ cΛ θ H H oo o t- t- r- oo r- vD r- vD i— o r- r- vo ιn ιn vD τ vo vo vD vo r- oo

CΛ •ςp m in m m T T *τ T T τ τ co ro ro ro ro ro ro oo oo co rO CM CM CM CM n OO OO CM rO CM CM CM CM CM CM CM CM CM CO CM CNl CM CM CM CM CM CM CM CM CM CM CM o o o OOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOO υ o o o OOOOOOOOOOOOOOOOOOOOOOOOO ooooooooooooooooooooooooooo

PM H H H H H H r- in CΛ CM H O in cΛ H OO CΛ OO T „ V0 CM 00 O O O r- 0-l t- , .. , i_n. .. o —o cΛ H r- r— τ t— rΛ r- oo m H VD H O CM oo r- v _o vD_ r.- 0 „0 C— CM VO CM rθ ιn CΛ

CO «3i rθ ιn CΛ H 0O OO H CΛ H H T T H T t- VO O O VO CM T 'q' VO CM O CM VD m co r- oo vD VD ιn m ιn τ τ oo τ H CM CM O H cn oo oo cn r- t- t— vo in in in in m m m in in in in in in in in in in in in in ^ T T T T -r T T T T

HHHHHHH HHHHHHHHHHH

T oo o rΛ oo m in cM co ro cΛ in o T t— oo o m oo oo oo cΛ tΛ O T t— in rH ro cΛ oo vo ro rΛi m m vD T H o o r- r- in T O H O CΛ CM CM CM vo t— vo cM O cn m oo H r— cn o H cn m t— H vo cn cΛ CM r- cD cn cM ro <ϊ* o τ vo vo oo r- r- r- cΛ vD in cM o o o ιn "βi σi o iΛ ro r- oo co co

(— σi t— CΛ CM in CΛ cO VD O rH T i-H in CΛ H H in H H in vo oo ιn vD H H τ ro H VD τ m co o ro cM cn cD ro o o o vo oo r- oo oo ιθ τ r- vD

O CΛ O O H H O CM 00 in m τ V0000000 r0 CM CM H CM H CM 00 H CM H H O <Λ O CM H 00 T in in τ T in in in ^•"3¹ -a* CM H CM T 'T in vD in in H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

^ in o T OO oo o H O t— oo cn co cn cn ro cM CM H r- T vo H T cn r— H T m H CM cn cΛ H Vo in vo σi in oo oo H O H T Oo r- cΛ vo cM oo r- oo m vo e co r- vo cM VO H CM oo ro H co cn vo in cn cM ro o H o CΛ vo — ' CΛ I— ro oo vD H CM CM CΛ oo r- O T T cuni muj rιo»ι iun^~ϊ rl^τo* rCo H rH cCoO t— in CM t— T H CO CM CM CM CO CM i CΛ I— oo cM r— ro oO H CM oo in ro r- m m in t— ^r r- 00 CΛ CΛ cM oo o H ro T O co t— ro o cn H vo ro o vo oo o r- CM CM ro co o oo ro m vo vo i— r- en t- co ιn vD τ θ H θ H θ W <Λ oo cM ro cM θ o 'r ^j' in vo oo co oo θ H CM ro rθ '3^, cΛ CΛ θ CΛ CΛ t— r- cD VD ιn ιn rθ H CM rH CM ro ro ^ιι CM rH ro r '3' m

^ TT ^ v rrin in inin in v^ vin inin ini in in in in ir in in Φ Φ ΦΦini w in in in inin in in ininΦ Φ βΦΦΦ WΦ Φ ΦΦ Φ Φ

V 1» r ^ <-» ^ ^ ^o ιn ln ln ιn ln ιn ιn ω φ φ φ ιo ^ ^ ^ ^ tD oo (D oo co (D co co o3 lJl l>l m σι m m ol Λ Ol O (Λ <Jl O O O O O O O H ri H H

(^ co ro ro co ro co oo cη co oo oo m ro co oo ro ro ro ro oo ro oo ro ro oo ro ro ro ro ro ro ro ro ro ro ro ro n ro ro ro ro ro ro ro ro oo ro oo oo ro ro oo ro ro oo oo ro oo oo oo ro oo ro ro oo oo ro ro n ro ro ro n ro ro n ro oo ro ro M

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

D D O D D D D Oⁱ Cw CU C^μ C C Cl^j C^H fiC fit fit fi -^ ^ -^ ^ ^ D D

_H H _Hl H3 H^ _HH H_H CO CO C CO CO C CO C _hH ^ _I-l _HH H_{H HH HH HH HH H}l _Hl _H5 J H^ _{HH HH HH HH} H >< >H H ^ O O O O O O ι< fi f rt: <; rt; fit fi fit rt; rt; θ O O O O O C C CD O CD O EH EH EH EH EH EH EH EH EH H EH EH EH EH EH EH H EH EH θ O O

H CM co o H CM H CM H H CM CM H CM Q ω ω fit CQ CD Q ω f-l f cQ Q ω Q w si c; o o o o o υ o zυ fitυCQoCDo^Qo^Qoozυ fitυCQυozo fitυo A C^Q CD CD A zoooυooυ o z O O O O O O O O O O zoooυoozυυo o H N l») •» o3!D co ωco

ΣoΣoΣoΣoΣo A A A A A

-sji in "3* cΛ σ vo

VO T CM CM CM CM O OO O OO

H T CM H r- ro oo in o H in cΛ oo oo o t— <j ιo r- C .M. τ τ r- CM m m σι oo cM τ o oo co VD σi cD H t— 00 0 t.— V _O C _Λ. C_Λ. O_O C_Λ. O_ H. . C-Λ. V_O O_ V _O V _O OO

T O CΛ CM H CM O OO T O CD OO T in θ ιn τ O O VO tt—— rO OO CΛ CM OO CM CM O VO T CM OO T T O in OO T Iⁱ VD H VVOO VVDD ⁱⁱ OOOO HH OO OOOO COOO CCMM CCOO CCΛΛ VVOO tt—- in oo oo o cM cn r- oo vo cΛ ro in ro vD vo oo ro vo cM vo vD C cMM H t— vo τ vo cM τ r- CM in ro co oo cΛ CM CD co o cM in o cM σi 'T H CΛ H CΛ ιn t- cM θo t— o cn

VD T T CO CM rH rH rH H O O o oo t— vD m ιn τ τ τ τ ιn ro τ cM H θ <Λ cM H θθ oo τ τ cM ro ιn m vD r- r- t— rΛ cn o oo oo r- H H H CO CM

T T T T T T T ro ro oo oo ro ro ro ro ro ro ro oo ro n ro cM ro ro ro ro ro ro ro ro n ro ro ro n oo ro oo -T OO oo oo

O CM O CM CM T i o O in H CM CO CM Cn in rO CO in OO CM H H CM 'S' OO VO OO H OO r- CM VO CO CM VD rO in H r- T in OO OO H OO OO H Cn r- T OO ^ OO OO H CΛ T OO in t— O rO CΛI cn CM VO CO CΛ CO CM VO CΛ CM rO VO H T VO O H CΛ H VD VO CΛ OO T OO H H OO CM in OO in r-- O H T OO CD OO in m H CO H in oO OO in cD co cM in H T CO o ro t— ιn cM vo ιn cM oo vo H in o ^ vo τr τ ιn H H ro cM vo vo r- 1— i- O M Oo cn cM CM o vD O oo H t— o oo o T O CO H in rH in

∞ ιn τ oo cM CM H in ιn ιn co t- ιn ιn ιn 'τ ιn ιn ιn ιn vo vo ιn t- τ ro τ ro ro cM CM H oo ro ro T VO CM rH CM H CM OO H CM O O H O CM CM ΓO T UO

H H H H H H H rH H H H H H vo o-i T O vo o in oo 00 CM CΛ rO CΛ in H CM r- in oo CM CΛ T in CΛ H CΛ H o cn vo oo vo vo r- o cM r- vo cM O t- o in r- co vo oo H cn vo rH m

OO CM CΛ CΛ CΛ VD CO T tt—- CM θ θθ ιn τ ro rΛ cΛ O CM ro 00 O r- in co t- T O OO O VD T T O O (Λ oo vo ιn oo oo oo τ vD CM oo cM CM oo τ m cM i H in oO CM VO CM t— VO r _ ^{Λi Λ}j ^, c O VD rθ CM O CM O t— o ιn o -» ιo ιn ^, m^Λ ^ r- " co" e"n H ^■ — co τ τ τ ιn τ ιn vo ^ ιn ^ vo r- t- rx) cn oo cn cΛ co o o H CM ro rθ H rH H CM CM ro ro «3' τ ιn co ι— vo t- ιn vD τ τ cM CM CM H O CΛ 00 O H CM O H H φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ r- [^ r~ r~ ι^ ι-- ι~ r r^, t~ r- r- r~ r* r~ r-' i^ ι-- ι^ r- ι- ι^ r r* ι r_' r~ r- vo vo i— r- r- r- t- r-

H H w N N ! c N N N ιo (0 ⁽η r ιn ^ ^ ^ ^ ιn ιn ιn ιn ιrι ln ιn ιn Φ Φ Φ Φ Φ ^ ^ ^ ^ ^ ^ o^ ω o5 to fl^ W (Jι ol αl o m ol o o o

T T T T T 'T T T T T T T T T T T T T T T 'T T T 'T T T T T T 'T T T T T T T T T T T T T T T T T T T T in in in co ro ro ro ro ro oo co ro c co oo oo co oo n oo oo oo ro oo ro ro ro n ro ro ro ro ro ro ro ro ro oo oo co ro ro co o^

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

C CO D D D D D D D D fit >^{H H} >^{H H} z z z z z z z e< H CH CH θH α; ω ω ω cd ω ω ω ω < ^ H >H D D D D D D D D pH CH Λ H >π t_ι ι_ι w ω i-, ω ω t-i HH H^ H^ H^ HH CO C C C CO CO C O ω td l-H ω ω ω HH HH HH HH HH HP HH j HH Hj H^ Hq t-l td

U U rl rl rl rl rl rl rl rl A U CD O O fit rtl fit fit ^ r fit rtl CO CO CO CO C tΛ H H H H H H H M O O O O l^ H HH HH HH HH HH H-l CO CO CO CM CM CM CM rO rO rO rO OO rO n Φ Φ Φ Φ Φ Φ Φ Φ

H en τ cM ro rH CΛ O CΛ C0 Φ Φ ln c _ OOOOO OOOO O

CΛ θ in H H θ r- CM r- vD θ ιn cΛ vo ιn o τ o H VD in cM vD co m m in o o o oo cM VD vo w oo oo r- O H ro vo in cΛ T T oO rH ^' CΛ in r- oo ro H ro

CO O m in CΛ r- t— T VO VO I— OO O H H in VD OO CΛ OO O H H t- H VO o ro ro τ τ m cM co H '3' <_) θ cM '3' vo o cM H τ r- vo cM c_i co o r- oo ιn ιn τ oo r- o o r- t- ro vo vo τ co cM oo oo cM r H (Λ H θ cn co cM <Λ vo H H t- cΛ τ ιn o cM in ιn cM '. '- CΛ CΛ τ r- τ m o o vo H ^i' oo oo oo ιn cM H H

CM oo ro in m in vo r- in vo r— r- t— t— CΛ cΛ CΛ oo cΛ CΛ cD cn cΛ O H C H CM C co T T i T VD r- oo oo r- t— t— oo oo r- r— r- t- co t— c— VO CD CO OO CΛ CΛ T T -T T ^ ^ T T T T T 'W T T T T T _'T in in in in in in in in in in in in in i in n in in i in in in in i in in in in in in ^

T VO CM O O H I— O O T VO r- CM VO t— T ro H r— CO CM CM t- Cn r- CM CO H O CD CΛ C- H cM t— in in r- ro T oo t— O CM CM H CΛ O CΛ vo i— in vo vo i— 1— oo m τ H H HH H H HH H H HH H H H oo ro vo T in cΛ o cΛ in ro co co H O r— CM CΛ T o r— CM O CO rO rO H O O CΛ OO t— OO CΛ CM O OO t- CΛ OO in H m H CM O cn co T VD CM ro ro oo m o H CΛ vo T 00 CΛ O O OO O OO OO in cM O O V VOO C CΛΛ H . H . . OO CO CΛ H VD O O H rO rO in H CM oo r- t— ιn r- ιn ιn τ cn τ oo oo oo cΛ m vo 00 CM r^» co cn vo CM vo cM CM t— m τ r- [— m τ co oo cn oo cn co r- oo oo cn en cn oo cn r- r- oo cn o H H Vo ιn vo ιn m m m ιn oo ro oo cM H CM H H H CM H ro o o cM i' co o o co r- vo ιn τ m t— co

[— ID VD VD VD VD VD VD VD VD VD VD VO VD VO VO VO r— r- t- vo co vo vD VD VD VD vo vD vD VD vo vo vD vo vo vo vD vo vo vo vo vD vD VD VD vo ιn ιn ιn m ιn m ιn m

o o o H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM co co ro ro ro ro T T T T 'T in in in in in in in in in in in in in in vo vD vD VD VD vo vD VD in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in ^ oo ro ro co oo ro ro ro oo n ro ro ro ro ro ro oo co ro ro co rn ro ro ro oo ro ro ro oo oo ro ro ro oo oo ro ro oo m

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ oή cή oi co cn co co cn w co co co cΛ co co co co M co ω co co c Mo cI,-ϊ lp<cJ Pl,i c^|,-l cl-cl c^|,c; ι^l! < ⁽< < rf Oι 0ι l- Ilι Oι l, Dι ⁽, l, l. l- ⁽lι l- II. D D D D D D D D

[i] C_ M H M l-H H I-l rH H I-I H H H M H H H H H rH H CΛ CΛ ift X X X X X X X X X X X X X X X X X X X 3- C C C0 CO M C eC fiC rt; fi H H H EH EH EH EH EH H H EH H H EH HH HH HH HH HH HH HH HH

CM H rH CM CM H H CM CM CM ΓO H H CM CO CM H CM

O fit CQ CD Q Q t-I W fit CQ O Q Q U ω ooozυυυozυzυozoυoυzozυo zυfit Cυ^Qoυozυfit PυQυo Kt P^Q O ^Q ω ω Q ω i^j si BC ft CQ CD a Q z o υ o υ υ υ υ z υ o o υ oz o o o υ o υ o

H CM ro T in vo r- oo cΛ θ H CM ro ^ ιn vo r- oo cΛ θ H CM ro τ ιn vo r- oo cn o H cM ro τ ιn vo r- oo cΛ θ H CM oo τ ιn vo r— oo σi o H CM rO 'S' in co ^. T T T T T T T T in in cn in in in in in in in vo vo vo vo vo vo vD vo vo vo r- r— r— r- r- r- r- t— t— t— oo oo oo oo oo oo oo oo oo oo cn cn cn cn cn cn cn Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ to co co oo oo ro ro m ro ro c m m co n oo m n ro n ro ro n ro m ro ro oo oo n ro oo oo m m oo oo oo ro r^

00 rH rH ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ∑ΣΣΣΣ∑ΣΣΣΣ∑∑∑ΣΣ∑ΣΣΣΣΣΣΣΣ∑ΣΣ∑∑∑∑∑∑Σ∑∑∑∑∑∑ o OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO O A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A

rt rt I- ro ιn o m cM <Λ vo r- o τ r- τ o ro ιn r- o cD ro oo ιn ro oo ι^| vo cM τ oo oo o τ r- oo m cΛ oo r T VD ro vo co H in H oo cΛ in o H oo m vo o oo oo JS T O in O CO O CM CM VD T OO H VO O CO VO t— τ co cΛ in ^. co vθ H vo r- co o ro H (Λ oo <Λ CM <x) H r- r- r~ r- ro cΛ τ σι σι cM <Λ vo oo vo ro o ro co cΛ O C_D CΛ VD CM CM rO T in in vo in co in in oo ro o rH vo vo r— o ^ C o ro in in cM rH O Λ H en en oo vo m m vD in m T OO T CM co H O O rH H O O

B cM ro cM CM CM oo ro ro oo ro ro ro oo oo oo ro ro ro oo ro ro ro in vo vo vD in in in in in in in 'T in f ^* Kf Kf Kf KI* ^* ^* ^* Kf Kf ^* Kf ^* T T T *cjⁱ T T *-3*

O O OOO O OOO OOOO O O O O O O OO O O O OO OOO OOO O OOO OOO OO O OO OOOO O OO O O O O O

H O O O O O O O O O OO O O O OO O O O O O OOO OO OOO OO O O OOO OOOOO OOO OO OOOO O OO O OO U α. H H H H H rH rH rH rH ro N 9 in ^ π r » rHH rHH SiOo ^ F~ H rH rHH H 0ω0 vVOB 0O c0o0 (CM VVDB iu o o ιc-o coι wvo (cM T7 conι mιn icM OU «oo) imιι vιou icM cunι cioD viou mιιι ciBo v-D H IΛ r- ^- CM O rH H t- '- CM O r- cn CO CM CΛ T H CD CM in H H CO CΛ CM I— H VVOO H VO CO O T H VO OO O t— Λ OO CM r- VO T T OO m CO CO rO OO CΛ OO O H OO CM Cn eM CM OO H H O CO CM H -P CM in CO t— θ r- CX) Cn CM CM in r- CO O O VO VO τ H O ∞ r- r- '3^| VD τ i— rx> VD τ t- -> CΛ T OO H θ rθ CO O T 'T r- r- m m H i— cΛ T T m o oo m co

O H CM CM T r H N H H Ol M fl '» ln ^ ιo ^■ ^ ιn ω ^ ιn « n ln ω n v ιn <f Φ ^ ιn o) lI) m o o ι o H H ( ^^ ^ ^ <r ιn ιn ^l) r-• Φ ^• ^ φ φ φ φ φ φ φ CO VO VO VD in VD VD VD VD VO VD V O VO VO ∞ ∞ Ca C» 00 CO 00 000O 03 0000 C» C» 00 O3 CΛ σi CΛ CΛ CΛ CΛ CΛ CΛ CΛ <Λ CΛ oo H T in o cn in H CM CΛ CO CO VO O H O in H CΛ H T O O CM Ln tΛ CΛ t- in OO in CΛ CjO Cn in ∞ r- CM H 'T VO OO ^. O CM CM '-' ^l' rH m oo CM ro T co in

T O O O H C t— OO t— in cn cn t— oo H τ ιn H H t— CM co (Λ oo o cM θ in τ oo oo r— H I— I— r- oo o c H CΛ τ r- o τ '3' θ o r- T o ro oo co vo co cD cM in m in σi H H 1- CM t^ VO τ rθ in θO O in τ O ∞ CM ^ CM H CM in rH 'T H H CM 'T CΛ Cn in CO VD r- CM OO VD θ rθ CM in ^. ιn '-- CM O rH T CΛ CM CM co vo vo m vo vo oo vD vo vo vo vo vo in r- r- oo r- co vo r- O O vo in co vo in

H H H H H H H H H H H H H H H H H H H H H H H H H H r in cs cM i^ cn co cn vo co vo o o^ o in 'T T O o r- T ro H ro in oo oo oo in cM ro H VD oo o o ro co cM vo r- N M n ^r ιn M' r^rι ιn Φ ^ N in r- c OO O OO O T OO in O CΛ T OO O O OO CM CM OO H O I— t— vo o cM cn o t— r- co vo t— vo oo τ m vo oo o ιn H t- "!r cΛ oo ro oo cΛ oo o r- r- oo co m o vD

H CD in VD CD CM CM eM CD CD T CM T ^ eΛ τ 0000 C0 CO Cn cM CΛ CM CM CM r- V0 CΛ H in CX) H H H O CM T O 0000 V0 H <Λ αD H CΛ I- in VO 00 CM r- vo r- oo VD in m τ cM H θ cM cM CM H H CM ro -r oo cΛ cn o cM ro τ cΛ cΛ oo o cn CΛ cn CΛ o o cΛ o o o H cn r- cn cn cΛ oo cΛ r- VD r- vD vo co cΛ m m ιn m ιn ιn m ιn m m ιn m ιn ιn ιn m ιn m m ιn 'v)' 'χi' H H H H o o o rH O O O O H H OH HH H OO OOOOOOO OOO OO rH rH rH rH rH rH rH rH H H rH H H H HHHrHHHHHHHHrHHHHHHHH

rθ O OO OO OO rθ rθ H H H H H H H

OJ ^jri J J iJ J J Hl J D D D D D D D D H Ei tH tH h H tH h O O O O O O O J J α H HH IH HH eC Q Q O O Q O O A ζ A A W a a ω ω a ω a ω ω ω ω iύ ω iύ ω ύ c cύ cύ oi ti A ti oi oi Qi oi ai ei oi EH EH EH > > > > > > HH HH H3 H H^ H^ Hl Hq ∑ ∑ ∑ ∑ ∑ ∑ C-. θ4 CH CL, C-l C-l CH > > > > ft Oi Oi Bi Qi ai CLi ai

H CM CM CM fit DQ O fit CQ CD CD ft CQ CD Q α Ul U Q -1 ft ^Q fit C^Q o fit CQ O CD A CQ Q fit CQ CD o o o o υ o z υ υ υ υ υ o z oυ o o υ υ oυ υ co υ υ z υ z υυo υυ z υ υ υ o o o z o υ υ o z o υ o υ o o ^o ^ _ m o H N ) « lΛ Φ ^ ω tι o H c^ι ro ro oo ro τ *. τ τ 'τ τ '<3^| τ τ _'τ ιn ιn ιn r- r- t- t— - r- r- t— t- r- r- t- t- r- r- r- r- r c^ ΣoΣ Σ Σ EHoEH oEHoΣΣ EHoEHoEHoΣoΣ EH EHoΣΣ EHoHoΣoΣΣoΣ EH EHoEH EH A A A A A A A A A A A A A A

fa tδ-

ATOM 3753 N TYR 3154 108. .633 17, ,479 98. ,004 1.00 39.09

ATOM 3754 CA TYR 3154 109. .682 17. ,689 98. .991 1.00 37.91

ATOM 3755 CB TYR 3154 110, .971 18. ,119 98. .296 1.00 37.75

ATOM 3756 CG TYR 3154 110, .841 19, .437 97. ,570 1.00 40.09

ATOM 3757 CDl TYR 3154 110, .157 19, .522 96. ,356 1.00 40.03

ATOM 3758 CEl TYR 3154 109, ,999 20, .751 95, ,704 1.00 39.70

ATOM 3759 CD2 TYR 3154 111, .368 20. ,617 98. ,117 1.00 39.82

ATOM 3760 CE2 TYR 3154 111, .214 21. ,846 97. ,472 1.00 38.84

ATOM 3761 CZ TYR 3154 110, ,528 21. ,905 96. ,270 1.00 39.55

ATOM 3762 OH TYR 3154 110. .356 23. ,113 95. .634 1.00 39.77

ATOM 3763 C TYR 3154 109, .274 18. ,739 100, ,026 1.00 36.94

ATOM 3764 O TYR 3154 108. .474 19. ,622 99. ,743 1.00 37.50

ATOM 3765 N TRP 3155 109. .822 18, .631 101. .230 1.00 35.27

ATOM 3766 CA TRP 3155 109. .518 19. ,574 102. ,299 1.00 33.87

ATOM 3767 CB TRP 3155 110. .107 19. .093 103, .621 1.00 32.01

ATOM 3768 CG TRP 3155 109. ,573 17. .786 104. ,143 1.00 28.02

ATOM 3769 CD2 TRP 3155 108, .220 17, ,322 104. .097 1.00 26.45

ATOM 3770 CE2 TRP 3155 108. .185 16. .066 104, .746 1.00 25.14

ATOM 3771 CE3 TRP 3155 107, ,035 17. ,841 103. .569 1.00 26.33

ATOM 3772 CDl TRP 3155 110, .281 16. .824 104. ,802 1.00 27.15

ATOM 3773 NEl TRP 3155 109. ,455 15. ,787 105. .167 1.00 25.80

ATOM 3774 CZ2 TRP 3155 107. .017 15. ,328 104. .885 1.00 24.17

ATOM 3775 CZ3 TRP 3155 105. ,871 17. ,101 103. .708 1.00 26.53

ATOM 3776 CH2 TRP 3155 105, .874 15. ,856 104. ,361 1.00 24.65

ATOM 3777 C TRP 3155 110, • 111 20. ,938 101. .969 1.00 35.28

ATOM 3778 0 TRP 3155 111, ,311 21. ,051 101. ,712 1.00 35.18

ATOM 3779 N THR 3156 109, .273 21. .972 101. .983 1.00 36.76

ATOM 3780 CA THR 3156 109. ,728 23. .325 101. ,678 1.00 37.57

ATOM 3781 CB THR 3156 108. .621 24. .143 101. ,025 1.00 35.80

ATOM 3782 OG1 THR 3156 107. ,605 24. .430 101. ,990 1.00 36.19

ATOM 3783 CG2 THR 3156 108. ,010 23. .373 99. .889 1.00 34.67

ATOM 3784 C THR 3156 110. .198 24, .056 102. .929 1.00 39.50

ATOM 3785 0 THR 3156 111. ,095 24. .893 102, .861 1.00 39.18

ATOM 3786 N SER 3157 109, .588 23, ,737 104. .066 1.00 42.72

ATOM 3787 CA SER 3157 109, ,954 24. ,356 105. ,342 1.00 46.50

ATOM 3788 CB SER 3157 108. ,848 25. .302 105, .822 1.00 46.20

ATOM 3789 OG SER 3157 108, .611 26, .330 104, .878 1.00 46.67

ATOM 3790 C SER 3157 110, ,165 23. .250 106. .368 1.00 48.51

ATOM 3791 O SER 3157 109. .391 23. .103 107. .317 1.00 49.78

ATOM 3792 N PRO 3158 111. ,232 22, ,462 106. .194 1.00 49.73

ATOM 3793 CD PRO 3158 112. .328 22, .734 105, .255 1.00 50.01

ATOM 3794 CA PRO 3158 111. ,586 21. ,347 107. ,072 1.00 51.06

ATOM 3795 CB PRO 3158 112. .908 20, .870 106, .490 1.00 51.19

ATOM 3796 CG PRO 3158 113, .496 22, .119 105, .971 1.00 50.83

ATOM 3797 C PRO 3158 111. ,698 21. .681 108, .549 1.00 51.91

ATOM 3798 0 PRO 3158 Ill, .358 20, .861 109, .402 1.00 51.46

ATOM 3799 N GLU 3159 112. ,170 22, ,885 108, .847 1.00 52.94

ATOM 3800 CA GLU 3159 112, .345 23. .302 110, .231 1.00 54.81

ATOM 3801 CB GLU 3159 113, ,107 24, ,623 110, .296 1.00 56.84

ATOM 3802 CG GLU 3159 114. .546 24, ,464 109, .871 1.00 59.34

ATOM 3803 CD GLU 3159 115, .006 23, .015 109, .980 1.00 60.57

ATOM 3804 OEl GLU 3159 114. .875 22, .424 111. .085 1.00 60.07

ATOM 3805 OE2 GLU 3159 115. .487 22, .476 108, .954 1.00 61.42

ATOM 3806 C GLU 3159 Ill, .070 23. .415 111, .032 1.00 54.75

ATOM 3807 0 GLU 3159 111. ,051 23, ,108 112, .224 1.00 55.32

ATOM 3808 N LYS 3160 110, .007 23, .861 110, .380 1.00 53.40 I- ro O _T T in CM H CO CD in ^ T CΛ CO rO CM r— I— rO CM O CM CO OO OO O H OO VO in CM H CΛ CM r- VO O CM T CO H T H in ro r- H oo oo m H T CM co oo H o cn cM co co cM ro o in vo vo T i— ιn ro o cx) τ τ cΛ t— CM CΛ O OO CO Γ— o ro cΛ in cM CΛ oo cM in cM in oo o o cn T VO r- H CM CΛ CO H CM CD T rO CM T CM

H CM CM oo in t— H o en r- r- vo m -- i— in vo in r- o cM H T rO CM H O O OO CO t— VO CΛ CΛ CΛ CΛ CΛ O CM T CM Oo cn m oo o co vD ^r rO H ro o T in vD m m m ιn ιn m m ιn τ τ τ τ τ τ T T T T T in in in in T T ^ji T T ro ro ro oo ro ro ro ro rO T T T Oo oo ro ro oo cM CM CM ro ro ro oo oo ro oo

H _O O O O O O O O O O O OO O O O OOO OOOOOO O O O O OO OOO OO OO O OOOOOOOOOOO O O O o o o υ O _O OO O OOOOO O O O O O O O OO O OOOOOOO OO OO OO O O O OO O OOO OOO OOOOO o o o o o o

PM

CΛ VD rH 00 O VD T T t- m vD VD CΛ H VD H VD CΛ VD τ m θ ro τ ro τ t— CM C T O O oo c cn m D T C c H r— cn oo oo O H O VD r- 00 CM in CD 00 --3* CO H 00 H CΛ t- co o t- en vo i— o vo t— oo o in o ro vo t— VD t- CΛ CM Cn θO jι m t- m θ H H rθ VO VD H H OO H T OO H H H CO O in CΛ T rO CM CD t— O CM <Λ CM rH T H oO rH CM CΛ t- ro vo ro vD o o m in vD vo r- cM t— r- r» cM m cn cn ro vo cM co m cM O r- m o vo ro cQ cn H OO lΛ m oO t- CM VD m OO r- o en CΛ CΛ oo en co r- r- CM CM ro T T oo oo ro ro m in m vo t— oo oo cn σv vo vo vo vo vo ιn τ oo ro r- r- OO CΛ H CM rH rO O O O O CΛ OO r-

H O O O O O O O O H H H H H H H HH H HH H H H H H H HH H H H HH H H H H H H CN CM CM eM CM CM CM OM H H H H H H H HH H HH H HH H H H HH H HH HH H H H H v o o

VO t- CO CΛ CM CM H O CΛ O CΛ 00 <Λ 00 O CΛ O H CΛ C0 O Cn 00 CΛ CΛ O O CM CM ι-l 00 00 r- V0 τ m oo oo cM in τ vo ιn ιn ιn oo τ r- 00 r» oo oo en o CM CM CM CM CM CM CM CM CM CM H CM H H H H CM H CM CM H H CM H H H H CM CM CM CM CM H H H H H H CM vo cn ro ro vD CM T T t— O H O in t— T CΛ CM T CM cn ro co o r- H VD CD H oo cM θ cn o τ o m τ o co ro t- CM τ τ cM τ H oo H VD ro ιn cM rH H o CM in ro T in t— m oo vo oo vo T CΛ oo r— t— r- oo oo oo oo in t— oo o o o H i- o cΛ CM oo ro r- r- <Λ ro vo cM ro vo σ> r- τ vo m oo oo H cΛ r- oo oo en t— Oo m vO CM CO O CO CO CO in CΛ oO T H CΛ O CΛ CΛ O H OO rO H m cM T CO t— T CM O T OO CΛ H O O r- r- T H H OO T H CM CM O t— ro oo m m H i- oo r- oo r- oo r- oo vo oo oo oo t- r- vo cΛ oo o o H τ ro tn o o cΛ oo r- vo vo ιn '3' r— o r— r— OO CΛ CΛ O vo m vΩ tn vo ιn τ vo τ ιn eo cM H CM H

O O O O O OO OO O O O O O O O H H H H HH H H O O OO O OO OO OO O OO H OOO OO OO O OOOOOOO HHHH HHHHH HHHHH HH HHH HHHHHHHHH H HH HH HH H HH H

o o o o o o o o H H H H H H H H CM CM CM CM CM CM CM CM CM ro oo oo n ro ro ro ro ro τ τ τ τ ^ '3' τ τ τ ιn ιn ιn ιn ιn ιn ιn ιn vo ιo vo vo vo Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H ro ro ro n ro ro ro oo oo oo ro ro oo oo oo m ro ro m oo oo oo m co ro n ro ro n oo oo n oo ro ro ro n ro oo n oo

C0 C C C CO C C0 CO EH H H H H H H EH D D D D D D D D D C C0 C0 C0 W C0 C0 C0 C C0 C W C W CO C C0 C D D D D D D D D CO CΛ C C C/-I

>^H -! ^ 1 >H >H i ω ω ω ω ω Cd ω W HH HH j HJ ^ HH HH HH H5 >H < >H H >H >H >^ !^ H3 Hq H3 .J H3 H3 H} ∑ Σ Σ Σ ϋ O O U O O O CD Hq Hq .-l l^ Hq Hq i-} H3 H3 H3 H} H3 H3 H^ H3 Hq H H3 Hq ^ ft PQ CD o. ω J fit CQ o Q ω υυυυozυo A PQ υ υ υ co υ υ o zυυoCDυQ vo t- oo cΛ O H CM OO T in in in in vo vD v^

oΣΣΣΣΣΣΣΣΣ EHoEHoEHoEHoEHoEHoEHoEHoEH

rt t- ro _5

I ιn r- CM vo o cΛ co H H Vo cΛ ιn ιn r- CM r- o oo H r- oo H r- r- in t— t— in ro o oo vD oo cvi cn t— oo t- O oo cM CM t— en o m co ro r- m co ro oo T OO i— S o m r- in oo m cM ^ co cM CΛ ro o co m cΛ O 'T VO H o ro r- m cM r- oo ιn τ τ cM ^i" θθ H vo o r- o cM vo cM oo cM co ιn H <Λ σι cM H T in -"S¹ T CΛ H t t— vo vo cN θθ o σ^ CΛ co co r- vD in '3^| ιn ιn ιn ιn τ τ τ ^,τ ro oo τ τ cM in ιn r- <Λ co o oo o o o oo ιn vo oo cn o co oo cn rO rO rO rO rO OO CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM OM CM CNl CM CM rO oooooooooooooooooooooooooooooooooooooooooooooooooooooooo u oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

PM

CM H θ m r- r- ro in r- r- H m cM CM m i roi vo vD i— oo t- o cM oo ιD H H (n _'I ln

H H CM CM CM CM cn m cD oo r- CM CM H t- ro o H o t— O T Vo oo in o cM Λ m oo vo H oo r- H Vo cΛ r- cΛ co cO T in VD in VO VO in in vO

CΛ t- r- CΛ CM OO H r- rO T CM Λi ι< n ιo ιn n Φ n rv rι oo cΛ O t- r- oo oo r- CΛ O Cn ιn ιn m oθ '- CM CM θ θ θ CM

H H CM rH H H H H CM H CM CM CM CM CM CM CM CM CM CM CM oo oo T in ro CM o t^ ∞ CΛ H CM I— T H O OO t— T O O rO VD in VO CΛ T I— CM in ^r O OO r- VO CM T in T O CΛ r- OO in H I— CΛ in T CΛ H ^ⁱ VO VO CΛ vo H ro T CM r- co r- co co oo i— r- ro ro cM !— ro t— cM t- ιn o H co t— ro oo o H τ τ ιn cn τ r- O CΛ 00 m T vo r- vD r- CM T Co t— in i' CΛ oo cΛ CM in o t— r- H T OO VO CM O in CΛ O OO T O Oθ rθ r- VD θ m ιn ^ι CM CM VO CΛ CΛ CM VD H VO τ rθ Oθ r- T VD rO CM t— OO CΛ VD VD VO CΛ CM rO m cΛ ro ro o H CM O H cn αo t— en vo i— r- vo r- m in r- τ τ ro cM H H H θ o cn H θ CM ro τ ιn vD r- r- ro oo ro oo cM H cM τ ιn τ m vo t- vo m

O O O O O O O O O O CΛ CΛ CΛ CΛ CΛ Cn cn cΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ Cn CΛ Cn cΛ CΛ oo CΛ CΛ CΛ Cn cΛ CΛ CΛ Cn cΛ CΛ eΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ eΛ Cn cΛ

VO VO VO VO VO t- r- r- r- t- 00 00 00 00 00 0D 0D CΛ CΛ CΛ m cΛ CΛ CΛ O O O O O H H H H H CM CM CM CM CM CM CM CM CM C0 00 00 00 00 r0 C T T -f T T 'T Φ Φ Φ Φ Φ Φ Φ r^*- r^*- [-* t^ r^ ι^ r- r^ r- ι^v r^ r-- r^*- t r* r- r^ p- r t t^ r^,- r^** r- r^ [ t ι^ t r-* r

H H H H H H H H H H H H H H H H H H H HH H HH H H H H H H H H H H H H H H H H H H HH H H H HH H H H H H H H ro oo oo ro co cη ro oo oo oo ro ro ro ro ro ro ro ro oo ro ro ro ro ro n ro ro ro ro ro oo oo ro ro oo ro ro oo co co co co co fi f fi fi f H-l ^ HH J HH H^ J O O O O O O O fit fi rti fit fit fi CC CO CO CO CO CO CO CO CO CO OH PH CH OH PH CH CH I-I I-I I-I HJ

H H H H H r r A A A A A Cύ X CXi Cύ t C& r rl l r j >H >^H >H >^{H H} >^H H >H >H a: 3 aH aH ac κ ffi fit! rt; fi fi BC X X X X ft ft fit rt| ft > > > > > > > cu c- cu CH Cι. cu C-i ft rt; rt: ft HH HH HH HJ HH H3 HH HH HH EH EH EH EH EH EH EH > > > > > >

H H CM H CM H CM H CM Q U fit CQ fit 03 oD o D fit CQ CD fit CQ fit CQ f cQ Q ω si z o z o o z υ υ o o z o o C oD C fiC CQ CD CD fit CQ O O z o o o o υ o z υ υ o o υ υ o o υ υ υ υ o z o o z O O O O O O o o υ υ o in va r— oo cΛ O H CM vo t- ∞ σv o H CM ro T in vo r- cxj cΛ o H CM rO T in vo t— oo σi o v VDo ^φVO VⁱuD vVOo ViBD tr—~ tι—- ι t—-- φ φ crι rι o o o o o o o o o o H H H H H H H H H H N

CXJ CO CD CO CO CO CO CD oo m o oo oo ro ro ro oo oo oo c^

00 H rH rH ΣΣΣΣΣoo ΣΣ ΣoΣoΣ ΣΣ ΣΣoΣΣΣ O ooH EoH HooΣΣΣΣΣ ∑Σ∑ o HoΣΣΣΣΣΣoΣΣΣΣΣΣΣ HoHoEHoEHoEHoH EHoEHoEHoEHoEHoEHoHoEHoEHoEH EHoEHoH o H H H ^Ho ΣΣ HoEHoΣ EHoEHoEHoHoHoEHoH ooΣoΣooΣΣoΣooΣΣoΣooΣΣooΣΣoΣooΣΣoo

A A A A A A A A A A A A A A A A fit < rt! ft fiC <! ι rt; rt; rt; ι=C rt; fit ι-t fiC fiC fϊ! rt; f- it

r- ro VO ro m σi vD in o cM in H T 00 H O O I— T 00 vo r— j o cn in in co i— o cΛ c ^ t- T OO ^ o αj T in vo co i ∞ T O co ro cΛ ro ro r- in oo cM CΛ S CM VD m o m cn co T OO ^r cM O co in cn cM Oo r r-- ro cΛ <Λ ^ n o ^ cn τ co vo vD vo t~ ιn ιn vD α3 θo o r H H r- vD τ cM ιH CM co ro cM co ro τ ιn ιn oo o

© oo oo o cM θθ oo ιn oo H H CM θ o o o o cn o cΛ ro oo ιn vo oo cM vo o cM in ιn τ ^. ιn ιn oo ιn vo oo t— r- r- oo cn cΛ o o o H H CM CM CM CO

CΛ 1 δ cM CM ro ro ro ro ro ro oo ro ro ro oo oo oo oo cM eo cN oo ro oo oo ro T T in in oo oo oo oo co eo oo oo •s-p T T T T T T

5 H oooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

U

PM

CD eΛ in m oo co H co in cΛ io cM CM r— OO OO T O T CM H croo iinn ^-T HH rroo vcoO TT rooo HH CCMM CCMM ∞Oo rooo TT CCNM CcΛn vvoo oo iinn vvoo oroO T'-' cooo -ino ccMM cooo ccMM T in cM T CO oo r- cn r r-- ceΛΛ vvoo vvDo rroo mιn ocDo oe»o oo ccMM CCMM iinn τ ro oo ιn _'τ cvoo mιn cσn^ H CCMM CCOθ CCMM HH oθoθ ccoo ccMM CCΛΛ vvoo oooo ccMM min iιnn oooo rr-- o o iinn r r-- c cMM iinn oooo Oo H CΛ cri T O CM H o co ro o in o

H CM OO rO OO OO O CM in O VO H cM Vo vo cΛ CΛ cM CM Vo σi rcon cΛ moo r—— l iΛn lmΛ lmi~ι cMi mcn rcΛΛ rcMi cjn^v rcort moo mro HH rro CcΛΛ vOo moo eO-} τT mCo r t—— C oOo r t—— T T CM T O vo ro H in oo in m ro oo H H H cM ro T CM CM CM oO T Oo m m vo o en o oo oo cn cn o o oo co vo vo T oo in r- m vo ro T in ro ro H o o o cn cn oo t— vo m vo vo T

HHHHHHHHHHHO H O O O O H H O O O O O O O O O O O O O O O O O O O cn Λ Cn cn cn cΛ cn cΛ CΛ rH rH rH rH rH rH rH rH rH rH rH rH rH rH r-i rH rH r -H rH oo oo vo t- cM in in vo m '- vo o OO rM O H H CO r- m CM CM CM CM OO in OO CM VO σi t- CΛ T t- rH VO '- I- in CM VO H vo τ cM r- cΛ in *-3' θo vo H H τ oo r-

OO CM CO H VO OO H -vP M H CM T H tΛ C0 H O CM CM H in H CΛ O '3i CD V0 VD 00 H in in CM r0 VD CM τ m r- r- O H H o r- oo r- vo H ro H O T H r- T t- T T CΛ O T OO in OO CM OO H VO O T CM O r- H in τ <Λ CM Oθ rO OO T <Λ ιn rH OO VD T <Λ CM CM VO CM T VD H r- co in i— cM O CM O co rM Ln oo H o ro

H CM CM CO T in VO VD H CM O O 00 00 oo r- oo vo t- o o o H CM ro T in vo o o o CΛ O CΛ OO I- H CM CM OO rO H H H O Cn CΛ H CM O H CM CM O cn O CM CM CM CM CM CM CM CM CM CM CM CM rH H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM H CN rH H H CM CM CM CM CM CM CM CM CM H H CM CM CM CM CM CM CM H CM

T CM in cM H cM in o r— m i— oo vo H Vo m r- ro cM ro oo H oo cΛ O T CΛ vo in cM vo cM in H t— OO OO CΛ H OO CM Cn oO CO O r— T O m CM VD 0 <Λ I— CΛ in o vD CD oo ιn τ oo cM (Λ τ τ m ro cΛ r- VD ro cM H τ oo vD ro r- t— τ ro cM CΛ τ cΛ H in τ ro σι r— t— iinn CCMM r r-~ 0O 0O H 0O CΛ in <Λ 0O <Λ rθ t— VD VD H V O H ro o T H oo cM vo t— vo oo t— m τ ιn ro τ oo o o cM in r— oo cΛ CΛ o vo vo in vo cΛ r— O T CΛ 00 ιn H r- OO CM O VD CM VO VD T H CΛ VO VO H in in t— t— t- t- t— oo eri eo cn co cn en cn o co o oo cn o cΛ H H H CM CM ro τ cM ro cM ro oo oo ro ro τ jι τ ιn vo m co m vo m τ LO '. VD VO VO VO VD r- VD cΛ CΛ CΛ cn cΛ cΛ cΛ cΛ CΛ CΛ CΛ CΛ en cn o en o en cn o cΛ o o o o o o o o o o o o o o o o o o o-o - o -o -o - o -o -oooooooooo

H H HHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHH

<)1000000 H ri H H H H cvl i— oo oo oo oo co oo oo oo oo co oo oo oo HHHHHHHHHHHHHH μi co co co co co c co co co ω ω ω ω ω ω ω ω ω ω ω co co co co c co co co co co c co co c c o o o o o o o oH pt. pH P« CM CM i^ pH H pH H CH H tt xxxx x x x xxxxxxxxxxx x x x x x x x x tύ & cύ cύ cϊi ύ cύ a tύ ω ω ω ω iύ i iJi tύ a ri

> HH HH HH HH HH HH HH HH Hl Cu Cu CH C-l C« eH C-l C-. pH PU Cu iH HH Hj j H^ HH HH HH HH O O O O O O HH C- CH PH Cu Cu Cu CO CO C W CO C C CO CO CO tO CO tD oz CQ O D fit CQ CD it O o z υ AυcQυCDoaυHzsioo A o CQ

O O O O z o o υ o o o z o f o CDoozo fito CQo CDυoz 00 (Λ O H CM rθ - in VO

rt r- ro vo '-' O vD CΛ r- cn cM T r c in m H oo r- m cM O CM CM Vo ro t- T VO ro H H H O o ^j' oo vo O T CM vo vo in cM in cM in oo in rH oo vo ro T T in oo S oo vo vo cM ro o oo o cΛ t- oo oo ro in τ oo ιn tM VD in vD CM cn τ o r- τ ro o cM co m ιn τ cn τ o r- o oo τ τ τ VD τ cΛ τ ιn m τ oo co H O T β o i T T in CO T H H O O H H H O OO OO CO CTl OO t— C0 00 CO τ m τ 00 T T T 00 τ r- CM T τ r0 CM CM CM 00 CM CM r0 H H CM in C0 CΛ O H

T T T T Kf Kf ^ * κ3* "^* Kf τ τ ro n ro ro oo ro ro ro n co ro ro cn co ro ro ro rθ M ro ro ro ro ro ro oo oo oo n oo ro oo oo m oo ro τ τ

O O OO OO O OO OOO o o o o OO OOO OO OOO OO O OO OOO O O OO O OO OOO OO OOO OOOOO OO υ H O OOO O O OO O OOO o o o o OO OOOOO OOO OO O OO OOO O O OO O O O OO O OO OOOOOOOO OO

PM

CM T T LO VD r— T CΛ OO r— T ro r- vo in cM CM Co in vo H o m cM in ro H σi o cΛ T T T Oo ^p o t— oo vo ro r- cΛ cM r- vo T T '- CM O '. vo ro o H CM ro cM T in cM in vo o cM ro in o in cn co T VO t- vo oo in m m oo m r- H CM _0O CM 0O H H CΛ H VO VO ιn 0θ rθ T 0O CM ιn CΛ H CΛ 0O CM VO T 00 CM τ m VO

OO VO I— T CM CM VD O in OO H T co m vo co vo H in vo in ro in vo cM r- T O H H OO <Λ CM rH CΛ ^)ⁱ OO lΛ rθ r- CM VO CM VO '3^l CM OO H CM <Λ CM in θO CO CM O

CO CM CM rH O CΛ CD O Cn eΛ CΛ ∞ CΛ OO O- O H H CM CM CM rO T CM rO CM '- in in VO VO in VO VO VO VO VO cn en cn cn cn c» co en co cD cx) oo oo co cn cn cΛ CΛ cΛ cn cn cΛ CΛ cn cn cn cn cΛ cn <Λ cn cΛ cΛ cΛ CΛ cn cΛ c^ oo T vo m cΛ in cΛ o oo cM cn ro co m oo oo oo t— m ro c vo oo ro cM CM vo oo ro o cvi oo ro t— H o m H . . c _n. i_n. τ m eΛ co r- r- H θ vo c- H m o H t— m H OO T Cn CM t— H T CO H t— CM in t— C— T H ιn θ H V0 ιn T CΛ 00 CΛ H O 00 H CM CM CΛ CΛ i_n. H vo _ o _ cM cn cM m ro cM ro T O r- oo r- in vo cM vo cM rO T VO H H CM VD in OO H i H CM oo cM τ ro m co o cM in H CM in tΛ t- oo vo H cn o r- r- co τ vo vo o o o T oo cn oo cM in cM '. H Vo ro cM cn t—

CΛ CΛ CΛ CΛ CΛ cD oo r- in oo t— cn cn o cM CM CM CM CD r- t- co vo vo co vo oo m ιn <» c1 1^, ι ιn Φ r- ^ ^ Φ ln ιn v r N ri o Λ ^ ^

H H H H H H H H CM CM CM CM CM H H H H H H H H H H

VO OO OO ^ CΛ CO H T CΛ Cn cO T OO T t— CΛ T VO H CM O VO σi T VO OO H CΛ CΛ t— t— in VD CM T VO VO in CΛ T T Cn oO T VO CM CO rO rO CM T T T OO VO t— CM CM CM OO O i-I O OO OO T OO CM VD VO t— CΛ O rO T OO OO CΛ T T OO CΛ Cn H T CM r- CM r- O T t— t— Ln VD CΛ OO OO in CM t— H OO O I— CΛ rO in VD T CΛ VO m o ιB ln ra '^ ^ ^ ^ ^ lπ t ( ι N o; o n H ^ H f^ n lfl ( ( x o ιπ ^ o (ι ^ » ( ^ o ( ι. u ^ ol o « H ^ <o ^ N (x O N ιJ1 (π H - vo vo τ vo m cD r- vo m vo τ τ ro cM CM CM θ CM H O H O H OO H CM ro o cn cn co c- CD r- co cΛ f- r- oo oo t- cΛ vo in i- vD vD r- vo t- r- vD

OOOO OOOOOOO OOO OO O o o o o o o o O O O O O O O O CΛ Cn cΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ cΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ eΛ

cM CM CM Co ro ro ro ro oo ro T T T T T T T in in in m in in m m m vo vo vo co vD VD VD r— r— t— r— t— t— t— oo oo oo oo oo oo oo oo cn cn cn en cn cn cn cn

C0 C0 CO ∞ CO 0 (X) O0 C0 Φ CO GO 0O 00 0O CO Φ GO C QO 00 GO (C 0O CO CO 0O 00 QO (S 0O 0O 0O CS 03 GO Φ 00 C- GO CO (X) CO H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H co oo oo oo oo ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro n ro co ro oo oo oo co oo ro M n ro ro ro ro ro oo M

X X X ύ PH PH PH PH CH OH O O O O O O O Z Z Z Z Z Z Z Z Z O O O O O O O OH OH CH DH OH O- PH D D D D D D D D O CD CD CD CD CD O O rl rl rl X X X EC X X X & & cύ cύ cύ ύ cϊi r r r r r r ri ri r cύ cύ u cύ c£, & x x x ω ω ω ω ω b3 u sύ aύ cύ ύ eύ tti cύ cύ cX

CD EH EH EH EH EH EH EH αi Qii- αi i-t- i-υei u uu uuuuiHiHi- i- i- i- i- h h H H H HHi ^ ^ i Hiri A A A A A A A A A

H CM H CM H CM H CM fiotυoz fiυt CυQ Oo CυDυo α ft eq o fi cQCD α ω ω a A to u> ft ca o o fit CQ O Q Q et co o Q ω si z υ υ υ υ o o υ oo o o z υo z υ υ o o o o z υ o o o o o υ o υ υ υ υ o υ υ υ o z υ

[- co cn o H CM eo τ ιn vo r- co cΛ θ H CM Co τ ιn vo r- ∞ cΛ θ H CM ro τ ιn '£> ι- ∞ cΛ θ H CM rθ 'τ

^ ^ ^ (B lϊl m (O eO (0 <O flO (II CO O Ol m φ m (Il (Il W Ol m O O O O O O O O O O H H H H H H H H H H N II N N N N I^I N N l n ( 0^{^}l CΛ lΛ CΛ CΛ CΛ CΛ CΛ eΛ CΛ CΛ Cn cn cΛ CΛ CΛ CΛ CΛ Cn cΛ CΛ CΛ CΛ CΛ O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O ro oo ro co co ro ro ro co ro ro ro ro ro ro i^ oo ro oo oo ro ro rO T T T T T T T T T T T T T T T T '- T 'T T T T T 'T T 'T T T T T T T T

00 rH o ΣΣ

EHoΣ HoΣ HoΣoΣooΣΣoΣooΣΣ ΣΣ ΣΣΣΣΣΣΣΣΣΣΣ EH EH EH H EH H EHoEHoΣ EHoEHoΣΣ EHoEHoEHoΣΣΣ EHoEHoEH oEHoEHoEHoEHoEHoHoEHoEHoEHoEHoH

O rt! rtj rt! fi fit f rt! f fit fit rt! f κt ft fi fit rt! f

t- r VO CΛ 00 ιn cM ro co cM C CMM CCMM τT HH ^'T. vVoD cCMM θO VVDD iinn HH rroo rroo rroo ccMM iinn oooo VvDD ιinn vvoD HH CcΛn ccΛn CcMM rr-- rt-- ccnn ιn t- oo vo in H O 00 CΛ O H r- ro o co ro r- js HH T O ιn HH cCΛΛ c<ΛΛ oo ccMM vvoo rroo iιnn vvoo vvDD '«T-ι^ι ccoo vvDρ ccnn ccn iιnn rro Tτ vDD CCMM CCMM im 'τ iι—— vvoo rr-- rr-- vD r- 00 O O H CO VO 00 T CΛ VD H vo ro m O CΛ 00 VD O Λ

© •Si O T © o H 00 r- in T ro CM H in ro CM H CM I- f- CO CO r- O T oo O H o H o 00 00 t- r- CM CM T in T vo r- in vo t- 1— CΛ CΛ CΛ CM ro in t— o CM 00 CΛ ro ro CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM 00 ro ro ro ro CM CM CM CM ro oo ro ro ro ro 00 ro ro ΓO ro CO 00 ro T T T T mm in in T

H o o o o o o o o o o o o oo o o o o o o o o o o o o OOOOOOOOOOOOOOOOOOOOOOOOOOOOOO υ o o o o o o o o o o o o oo o o o o o o o o o o o o oooooooooooooooooooooooooooooo

PM rH rH rH rH rH rH cn t— o cn cΛ H t— ro o vo CΛ OO H rO CΛ in H CM T m CM O rO CD CM eΛ rH m VO CΛ I— T H in H H CM in r- o oo o cΛ H CΛ CM cM rH T n oo vD in T in oo r- t— -T in vo ro in r- t- o o cΛ ro cM CΛ vo o co m ro vo vo cM cn cM Cn τ <Λ co τ τ oo cΛ H r- '- vo r- ιn ro ιn oo cM in ιn --3' in cM θ CΛ CM CΛ cM τ τ ιn vo r- t— t— t- CO VO VO CM CM rO OO T VO VO VD CM CM H o cn oo o en o CM CO CΛ t- o o o o o o o o o O H H H H H H H H H H H H H rH O O rH O H H O O O H H H H H H H H H H H H H oo in vo rO T H vo H H r H in ro cM cn m τ vD o vD •T OO T VD O^ H ro cM ro in H ro oo oo vo H in o oo vD oo H oo o in i-i r- T CM CΛ CM ro r- vo cM oo

VD H H CΛ T VQ OO in O CM <Λ 00 tM T t- O CM CM ιn V0 H O H tΛ Co cΛ m m oo T H r- ro o oo r- H H O CM ro o H oo ro r- vo H H O r- r- σi cM rH H

<Λ CM CM Cn r- oo H r- o ro o H co H OO T Co cn vo in H H in vO H H H T T O O vo t— oo m cM VO in o t— ro cM oo cΛ oo co co m o oo vo T CM oo cΛ r- vo ro ro cM CM co in in i— in vo r- i— vo r- H O O CΛ ∞ cD t— t— vo r- vo ιn ιo r- vo ιn τ ιn τ τ τ τ τ τ cM H θ θ ιn vD ιn ro

OO VO in O CM t— OO rO H n o OO o0Oo0O v VVoDD o 0OoO0 o0Oo0O CCMM r ft--- O OO rrr--- OOO TTT ttt——— OOO CCCΛΛΛ CCCMMM VVVDOO iiinnn OOOOOO CCCΛΛΛ OOO iiinnn VVVOOO OOO OOO CCCMMM CCCMMM CCCOOO CCCMMM OOO t- O CM VO CM O OO rO H CM OO O H Cn CM H m o Cn θ H O H O H r- H OO OoO r 0Oo0O r- C ^~~Λ θ r- OO H O VD CΛ ιn CM CΛ CΛ VO VO VD T <Λ CM VD r- VO CM T CO <_> H cn t— CM r- in r- oo m t— CM oo vo o T H t- o vo in oo o cΛ ro oo T in oo T O oo oo T t— oo oo vo oo cM O H i— oo ro ro ro cΛ oo τ cM r- r- o cn τ m oo oo O T O CΛ o r- r- vo oo oo t— CM oo r- cn oo o

^ Φ ω ιn ιn ^ r- o Φ Φ co m <Λ ln v Φ ^ ^ oo ιn Φ ^ ιn ιn ( o^ (^ι (^l H ιn ιn Φ r-• ^ ιn • ^ ^ co Φ ι 'l^{, ( (} 'l^| ^ ^^ (») 'l^, r cn cn cn cn cn cΛ cn cn cΛ cΛ CΛ CΛ cΛ cΛ CΛ cn eΛ cn cn cΛ eΛ CΛ eΛ CΛ CΛ cΛ eΛ cn cΛ cΛ CΛ cΛ cΛ cn cn cn

en cn en o o o o o o o o o o o o o o H H H H H H H H CM CM CM CM CM CM CM CM CM rn ro oo ro ro ro cη ro T T T T in in in in Ln in in in in vD

CO CO OO CΛ CΛ CΛ CΛ CΛ CΛ CΛ Cn cn cΛ CΛ CΛ Ch CΛ Cn Cn cn cn Cn cΛ CΛ CΛ eΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ Λ CΛ CΛ Cn cn en C^ H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H ro ro ro ro ro ro ro ro oo n oo ro ro ro ro ro ro ro ro ro n ro m ro ro ro ro oo n ro ro oo oo oo oo n

0 0 0 *-^H C^M p^y CU CH C_ Oι PM CM CM CH Cύ C_ llι D D D D D D D D W OT W rø w ω rø r-S pH CH CH CH CH pH pH CH p- pH PH CH H CH^' OH CH w ω ω ω ω E^H H H B H H H E* H H H t^H j hH iH iH ^l iH ^l ^ ^ _tH ^ J J J J J J i5; < O O c3 J

CM CM CM CO H H CM rO CM H CM x fit cQ O Q ω ω Q ω i N aH CQ CD Q Q D Q oυυooozoooυ A t CQ C o z O υ υ O υ o z υ υ υ υ ω H CM

SI zooz υ o z fi Q Qυoz Aoυo et co Q ω si υ o z otυ C υ CDo Qz υoooυzυoz

rt rt t- ro o CΛ VD rO VD H I— CΛ CΛ in t- cn VO Cri OO OO CΛ in CM O T H VO H H H CΛ VO VD VO O O CM CM O I— CO I— in O CM in CΛ T T O T CM r- cΛ cΛ vo m co cΛ ro S - r- ιn oo o cM r-- vo o oo o cΛ τ m cM τ ιn oo H θ oo o oo tn H o m cΛ cn H co cn o co H Vo m in r- Λ H o co H m o ΓO H OO H H VD OO ΓO OO VO

©

© * ft ιn r- H τ m τ τ ro vD vo cΛ τ r- vo o^ t— oo vo t— vo m τ ιn vo ιn τ τ ro cM T T ro T in t- oo vo oo oo cM CM in co cn cΛ cΛ cΛ O CΛ co i— ro o oo vo T

CΛ T in m in n T T T T m in in m i i T T T T T T T T T T T T T T T T T T T T T T T T T T -T T C ro ro ro r c CM C

-r>

H o _ o_ o_ o. ooooooooooooooo o o o o _ o. o o. oooooooooooooooooo oooooooooooo υ ooooooooooooooooooo oooooooooooooooo ooooooooooooooooo o o o o

PM HH HH H H H HH H HH in H vo ro H T CM Co t— I— CΛ CM H VO VO Γ- CΛ CO OO OO O H ΓO T H T -T O CΛ Γ— r— o in r— cΛ τ vo o oo oo vo cM oo H θo oo o vo τ <Λ θ oo ro m ιn vo

VO O I— T O OO rO H O O O O I— CM OO CM O >I CM CΛ CO VD CΛ VO VD H H H r- rO T i— o cΛ co co o m τ cM vo H in o oo τ o o r rH CΛ ιn ro H CΛ H

CM o r- r- r~ CΛ H t— CM O T VD H CM OO T O H CΛ r- O VD CΛ H T O CM H <Λ CM 00 0000 O H O V0 σi 00 Cn CΛ T CM VD V0 VD VD 00 CM T V0 00 O CM m H t— vo T CO CM ro oo oo oo en en oo o^ r- oo vo r- oo vD oo oo r— oo o oo t— m oo Φ O cn o o cn co en H CM H CM CM H O O CΛ CΛ T m τ m ιn ιn ιn vo t—

O O OO OO OOOOO OOOOOOOO OOOO H O O OO O H O H H O O O H H O O H H H H H H H H H H H H H H H H H HH H HH HHH H H HH H H

H CM VO VO H ro vD vo cΛ oo T Oo ro r- cΛ O r- cΛ ro oo T i— CM vo cM ro r- CM H r- τ ro ro ro cΛ τ cΛ in vD τ cM cn ro ro cΛ vo o H m o cM r- [— t— vo

<Λ r- vo r— ro « 9 ino oi N r- Mn <j ιjι « ιn r- o r- N in π H ιr,oι o_o in O T T O oo T H T Oo o cn m cM CM O O cn H vo cn in r- oo H T cn vo oo oo T CM ro o [— CM θ cΛ H τ τ τ m ιn m τ oo cΛ m ro ιn cM t ^"— <Λ ^_ r- V 'D- t -- r -o^" c ^"o- CΛ O OO H O H VD OO O CO T in rO in CΛ VD O CΛ VO CM T CO CM T

VD VO t— t— OO VO t— I— CΛ CΛ H CM fO CM T OO T O O O H O CM CM rO rO τ m τ τ τ oo cM CM CM ro ro cM H H H o cn oo cn co r- H H rM rO T in m co r-

H HH HH H HH H H H H

T ro τ H in ιn oo vo cM ro r- H τ t- ιn τ vo cM θ o cΛ CM Vo ιn <Λ t— vo vD O in o o vo o to r- cD O in vo co t— cn r vo o oo r- cΛ in H VO T Oo ^ oo H o o ^O (!l tD O O\ oo M ra ιB H ^ ι ιn H H Ol N ω ιη (O N Ol H (^ι m t ω ιι^ H O ^ lJ^ eo H co ^n oD H H ^ «l Ol ιJ\ ι^,l H H _ m (! H _ CO l ^ H O ιo cIl ln ιo (^) o ιJ ιn co (I) « ^■» (Jl Ol ι o ^ ιn o v^ N O (Jl H H O H ιι1 0 Φ (n o^ ι oo ιfl N l^l ( «^, ^lJ (^,) ln - 0 ^ α! N O

N H N H H ⁽Λ H O H H H H O H O H O Ol Ol (D ^ ^ Φ ω ^o ιt) lι^ ι() ^ ^ 1^ ιn N H H O (n N v ιrl ^ ιo ln ln Φ lΛ ^β ιn ιι^ r• r- <ι) !ll lIι

CΛ CΛ Cn CΛ CΛ CO CΛ Cn Cn cΛ CΛ CΛ CΛ Cn cn CΛ CΛ CD Cn CD CO CO CO CO CO CO CD CD CO OO CO CO CO CO CD CO CO ∞

vo vo vo vo vD vo vo vo r— t— r- r- i— t— r- r- r- r- r- cx⁾ co co ao oo cn cn cn cn cn eΛ cΛ o o o o o o o o H H H H H H H H H H CM CM CM CM CM CM CM

Cn en cn CΛ CΛ CΛ CΛ CΛ CΛ en cΛ CΛ CΛ CΛ CΛ CΛ Cn cΛ Cn cn CΛ eΛ CΛ Cn CΛ CΛ CΛ CΛ CΛ CΛ CΛ O O O O O O O O O O O O O O O O O O O O O O O O O H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM ro n oo ro ro ro ro n oo m ro ro ro ro ro ro n oo ro ro oo oo n ro oo oo ro ro oo ro ro ro ro ro ro oo oo n ro

D D D D D D 3 θ cd ω ω td ω td ω ω ω td ω co co co co co o o o o o o o _ CH C M ⁽iι u

A A A r r X X X C Cύ ai ύ ai Cύ W W Cn υϊ W Ul Vi W rH rH rH rH M rH rH rH O O O O O Cu C ai CU C I-u CH CH CH H M H Hl H-l H^ Hl l^ C H

H CM H CM H CM H CM CM H H CM ft CQ o a ω w fit cQoaaωωsi ct ca Q fit CQ CD fit CQ O O- PQ U υ o υ υ o o o o z υ υ oυ υ υυ υo o zo o υ z o o o o o o z ooυooQooz fiυt CυQ OυυQ QzWυrz-Hυoz fiotooo Q Uz So!

CΛ O H CM CO T in VO r- OO CΛ O H CM CO T in VO I— 00 CΛ O CM ro T in vD t- oo cΛ O H CM co T in vD t- oo cn o H CM ro T in vo r- oo cΛ O H CM rO T OO CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ Cn cΛ O O O O O O O O O O H H rH H H H H H H vM CM vM CM CN CM CM CN CN CM ro oo ro ro ro ro ro ro oo ro T T T T T O O O O O O O O O O O H H H H H H H H H H H H H H H HH H H H HH H H H H H H H H H H H H H H H H H H H H HH Kf ^3* ^* ^* Kf ^ ^3* ^* f "i* ^3* ^* ^* ^3* f ^* Kf *3* ^3* "O* Kf f ^f ^ ^3* Kf ^p ^3* ^* ^3* ^* ^3* ^* Kf %J* ^3* ^* Kf ^* Kf Kf Kf Kf Kf ^3* Kf ^* ^* ^3* Kf Kf ^* ^*

00

∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ ∑ O oooooooooooooooooooooooooooooooooooooooooooooooooooooooo o rt; rt; fi fit rt! rt; < rt! rt; κt fit rt; f fit fit fit rt: rt; rt; fi fit f < rt; rt; rt; ft rt; fit fi rt; κ fi rt rt; fit fit fit < < rt; rt! e it

T T CM VD in cΛ oo H t— VO H VO VO in T en T T co OOOOOOO OOOOOOO oo cn ro vo o o t— vo τ cn r- cΛ oo vvoo rmo vvoi- rl—- H H cOΛΛ θCJ HH OO H OO CΛ H m CM H CM m O r— t— H in cn cM cn cn cΛ CM ro vo oo ΓΓ—— c cMM iinn oooo mm ιinn vvoD τT OO CM O vo r- oo T 'S' CM T Co m ro mro it—— . i von moo rO- 1 T mCo moo moo T rt—- iinn T iVDn mCΛ iVOn iVDn rσni —H iVDn O O H CM T OO in OO T T H

VD OO in T CD r- OO OO CΛ O CD VD in T OO OO rO CM CM CO H H O H CM ro cΛ CΛ CΛ oo σi cΛ cΛ cΛ oo r— oo vo in in T CO in T in T i o oo c H O rH H H H H H H H H CM H H H H H H H H H H HHOOOOOOOOOOOOOOOOOOOOOOOOOO

O H VD cM t— cM cn in t— t— o ^ in in H n t— in oo cM CM in t— vo in oo vD vo ro r- oo H r- in cM in cΛ H oo cM O o cD T oo 'T O r— cM o O σ CΛi HH C CMM OO I- T

(Λ O N ιn ιl1 0 H oo a Iι ιβ ^ N O) ( W oo ιn n ln H v Φ ffl (^ι ι»l ^ ι. ^ ^ H H ln α) ln ^il H O ll co o o o O ι^,l 0 o ^ voo ^ r- l c!nl CM in vo τ r- eXj rθ H rO VD CΛ H ιn ιn θO CM τ H CΛ CD r O OT ∞ τ rθ O H ∞ ιn c T CM OO CM CM H VO ∞ CΛ CM CM O C^ oo cn

T in in vo vo m vo vo t— t— oo cn cn cn r- t— oo oo r- oo r- vD ιn ro ιn τ oo cM cn en o H CM CM ro ιn vθ H H θ θ (Λ CΛ oo H CM CM Cθ 'τ ro ro cM CM H

H H rH H H H H H H H H H H H H H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM H H H CM CM CM CM CM CM CM CM CM CM τ vD ιn oo r- oo oo oo vo H CM vθ H oo cM ∞ oo τ vo τ vo o H CM CD in o oo cΛ τ τ τ ro cM H τ ro ro τ ro oo τ m τ m t— Γ- Γ- CΛ O O CO CΛ H H O O CO I— CΛ en CΛ oo t^ oo t— H CM H CM CM τ cM CM rH θo τ τ ιn vo ιn vD in ∞ co oo oo co co co cD CD Co co cD co ca ∞ co co ∞ co co co oo cΛ eΛ cD OD cn cn cΛ cn cD CO co co ∞

CM CM CM CM ro ro ro oo ro ro ro eo T T T T in in in in vo vo vo vo vo vo vo vD VD vo vD vo r— t— t— t— r- r— r— r- r— oo eo oo oo oo co oo cΛ CΛ CΛ CΛ eΛ o o o

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ co co ro co co ro co co oo ro ro ro ro oo ro ro co ro ro ro ro ro ro ro co ro ro ro oo oo ro oo oo oo oo oo co oo ro W t C 01 W θ Hl H >H H >H l >H rt; tH iH j ιJ hH u m u c3 ij αi iH „ A A cύ & cύ eύ c x x x HH HH HH HH HH I-1 A A A A > > > > > > > eC fit fit rt! rt; EH EH H υozofit CυQυoz fiotoCQ O o CM ^*

fit

t- ro 3 CO CM T O r- t- H H O O VO H cM ro ro r- H H ro cM T in cM ro m H H <Λ CΛ H CΛ Cn 0O CO VD t- t— CΛ θθ r- ιn ι-I O OO OO CM CM CΛ H CM T in CM H r- JS oo m ro oo o co ro cn co i— H I— vo o σi H CΛ vo vD m in co cM o ro o ro T t— ro T oo cΛ T Oo m oo cn oo c in in r- ^ji c H H c H o in oo H cn in oo β © cn en cn cn o cn co en o co co co t— r- vo vo ιn cD in ιn oo '3^, τ τ ro oo cM o H H CM CM CM ro ro cM θ θ CM cn cD VD τ cM CM CM ro τ ιn τ c^ o cn en CΛ CM

CΛ ro co ro ro τ ro ro ro τ ro oo ro ro cη ro ro c oo oo ro ro oo oo ro ro oo ro ro ro ro ro ro oo r^ CM H H H CM ooooooooooooooooooooooooooooooo OOOOOOOOOOOOOOOOOOOOOOOOO

H O O O OOOOO OOOOO OOOOO OOOOOOO U ooooooooooooooooooooooooooooooo

PM H H H H H

CΛ ιn r- H r- H rH T CO T VD ιn CM rθ H VD OO O T - O _ H . . C _Λ. CCΛΛ rrθθ CCΛΛ TT VVOO HH TT VVOO HH OOOO TT tr—- vVOo oO iinn mm oθ oO T'3' OOOO vVoθ rroθ H V CDO CCMM CCMM OOOO OO OO in CΛ OO OO r- T in τ T C^ T VO ιn CM OO CM CO VD VO CM rθ t- r- r rθO VVOO HH TT HH HH σσii CCMM HH OO VVDD CCΛΛ OO CCΛΛ HH OOOO CCΛΛ VVDD VVOO VVDD OOOO iinn CCΛΛ VVDO H rO OO rO r- rO OO H T t— t— co CM . cn T VO CΛ in CO O rO H CΛ H CΛ CM r— OO Λ OO O in t— CM CM in oO T«ι CmΛ mOO tr—-. VιOo iιnn Hrj Tw CMj ΛCMi rCMo OmO CcDO CtvMι θO iLnn iιrnι vOo tr—. tv) ^^, ι inn rr--- (c^n ιmn ^ΛcMJ θcθo θo rr--- O ^ cθ

O O O O _ O _ H H θ H θ H H H CM oo m m τ τ m oo oo ro H O CΛ O _ H o oo cΛ co in in in r- co t— t— VO OO Cn CΛ O CΛ CΛ O H O CM rH CO O O CM o o o o o o o o o o o o o o o o o O O O O O O O O CΛ o o o cn cn cn o o o o OOOOO OO H O O rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH H H H H H i ra ln ιn cft (η ιJl H CIl ι. o N Φ

O H O CΛ oo oo r— ro ro τ co r- vo vo ιn ιn co ιn r- τ τ rθ H H H H H cn ro rθ H θr> θ H θ CM H ro τ H H θ o e» ∞ ι- vo o H θ H ro ro ro ιn o

CM CM CM H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H CM CM CM H CM CM CM CM CM CM CM CM CM CM CM H H H H CM CM CM vo OO in H H T H H OO CΛ m H OO T r— CM O O T H CΛ CO CM ιn CM OO T CM O Cn ιn in τ VO H CΛ T CO O r- r- in CΛ H CO H CM OO T VO fO OO O ιn oθ VO CΛ o vθ H CM θ H r- co vo vo cM θ ιn r- cη r- o o ιn H τ cM τ vD H H co τ τ H CΛ Vo vo r- r- oo oo ro <Λ H α3 CΛ vo τ o ro ιn o τ vo t— vo vo H t— o cn vo ro o H oo cn in vo oo o cM cn cΛ H H H Co cn vo r- t— m cM in o ro H T t— r- t- oo vo cri ro H CM O H oo vD t— in ro m T H CM O CΛ r- τ o oo H CΛ ro

V i M ^ m N H ^ X Φ lO in ω Φ OO (Λ ai ^ ω (110 l)1 βl H H H H O H H rt O O I)10 <θ ro θl ^ Φ in Φ Λ in » '9 910 ιn i») Pi n ! V I«) ( cn cΛ cΛ CΛ cΛ cn cΛ CΛ CΛ cn cn cn cn cn cn cn cn cn cΛ cΛ O cΛ cΛ o o o o o o o o o o Λ o cΛ cn o^ cΛ σ^ Λ CΛ CΛ CΛ CΛ CΛ CΛ cn cn cn cΛ cn cn cΛ c^

o o o o o o o o o H H H H H CM CM CM CM CM CM CM ro ro ro ro ro oo ro ro co r ro ro oo oo T T T T T T in in in in in in in in vo vo vo vD vo vD VD

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ ro oo ro co oo oo oo ro ro ro ro m oo oo ro ro m ro ro ro ro ro n ro ro oo m ro ro ro ro ro m ro ro ro ro ro ro oo oo ro n fit ft fit fit fit p_H D_H & C θ_H θH Q_J n. r_1< θH Cu pH .^ pH C^ I^ ^" HH¹ rl HH HH _C X i i i i i iH oi Λ iϊ iij Λ ^ i- rt βi Bi Bj Λ t- ω ω i- ω t. ω j iJ hi Hi hi ri ^ J iH j j j j Hi Hi

EH E^{H H} H E^H EH EH EH EH fit fit fit ft fit EH EH

H H CM CM H CM CM CM OO H H CM rO CM CM H H CM H H

1o} Qoυ U Qo Uυυ H Soooz fiυt CoQυoz fiυt CυQ CoD CυDυo Kot CυO CυD QυlυdυCd QυUzυt- SυIo-Cυozo fito CQ CoDoo fit CQ O O Q fit CQ CD CD ^Q o υ o o o υ o O O

H CM ro τ m vo r- co cΛ θ H CM ro τ m vo r- oo cΛ θ H CM rθ '3' in vD t— co cΛ O H CM rO T in vo r- oo cΛ O rH CM OO T in co r- oo cΛ O rH CM OO T in vo

O O O O O O O O O H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM rO ro OO n rO rO rO OO OO OO T T T T T T T T T T in in in in in in in CN CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM OM CM CM CM CM CM CM CM CM

^* ^f ^* ^* Kf ^* ^* ^* ^* ^* ^* ^3* ^* Kf ^3* Kf Kf κ* Kf ^* ^* ^* ^* ^* ^* KT ^* * * ^3* Kf ^3* ^* Kf ^3* ^* *-3* ^* ^3* Kf ^3* Kf ^3* ^* Kf Kf ^* Kf ^3* ^* ^* ^3* ^ ^_** ^3* ^*

00 rH rH rH ΣΣ∑∑∑∑∑∑∑∑∑∑∑ΣΣΣΣΣΣ∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑Σ∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑Σ∑ © O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O o EH EH H EH EH EH H EH EH EH H EH EH EH EH EH EH EH EH EH EH EH H EH EH EH H EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH H EH EH EH EH EH

A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A tt A A A A A A A ft A A A A A A ft ft A A A A A A A A A it

rt rt t- fO o 00 O0 00 CΛ VO VD VO H r- CM LO CM OO O oo co in o cM in in H H t— H cΛ oo oo ro r- rΛ vo r- <Λ τ m cn oθ rH θ oo vo oo . cM. in. m. τ r .- t- o _ r .- in t- r- JS t— H Vo ro m H O ro t— in ro co H oo oo oo m H oo in oo H ro ro ro in cM VD CM CΛ O in cM in oo H oo eΛ H tt—— i mn rroo vvoD iinn cΛ tt—— CM iinn τ cM CM ro τ

H cn co r- co (η cM τ ιn vo r- oo oo ιn τ τ ιn co r- ιn ιn τ n H CD H ro ro τ ιn ιn ^ cM vo ι- ιn ιn ιn Ln vo ιn ιn vo r- crι τ t—

( CM CM CM CM CM CM CM CM CM CM CM CM H CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rO CM

OOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H υ OOOOOOOOOOO OOO OOOOOO O OO O OO OOO OOOOO OOOOO OOOOO OOOOOO O OO O OO

PM HH H H H H rH H H H

H cn cΛ oo ιn r- vD VD in r- τ oo τ cM CM c- cΛ ro oo r- oo ro H CM Vo oo vo t- t- <M oo τ oo H t— T Γ- H ΓO CM O CM T ro o in cM o ro cn cn cn co T H oo o oo co vo r- vo T H cn H H vo cM rH CM O T in m cM CΛ T H vo ro T r- ro m in in T oo t— H cn oo vD oo r- i— H C- T OO CO _CΛ VO CM CΛ T VO CO CΛ r- H τ H H r- r- τ r- r CΛ CM H ro o cn vo τ ro ιn oo cM in (Λ CΛ θ H CΛ vo H '-i' ^)i τ vD in t- cM Vo vo oo H <Λ cM H r- ro cM o m ro cΛ o cD t- m H o o

CM T in m in in VO VO VD r- VO I- VO r ∞ OO Cn θ H CM O O H H O CΛ C CM n CM OO Oθ r r CM T VO T VD r- r rθ rθ CM H O O O O CΛ CΛ CΛ CO O

H H H H H H H H H H H H CM < CM CM CM CM CM CM H CM CM CM CM CM CM CM CM ( CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H H H H CM H m τ H ro r- ro o r- cΛ τ o o t— ιH θ^ ρo τ H CM H CM oo en cΛ r- ιn τ r- cΛ in r- cΛ H θ ιn t— oo cM 'T in cΛ vo cM oo vo o ιn ro vo oo τ H oo H τ o lO H CM in H 00 00 CM CM r-ι ^■ if-- ro irO'l vO- it—- CM *V_0■ 0 H CM CM σ^ ιn C0 α3 O 00 CT) T (η CM r-- V0 O V000 CD σ^ V0 O 00 CΛ t- T O ιn CD ιH CM T in in VD H 00 CM in cΛ oo o cn oo m oo r- t— VO H OO T H CΛ Γ- in O OO O T VD H t- r- T CM H CO CO O CO CM CM r- CM O 'T OO CM -T OO CM OO CΛ rH σi CM OO T OO O CΛ VD CO o o o cn t— VO VD H H H CM rO T T in H O CM CM CM CM O CΛ O CO CO CΛ CΛ OO OO VD VD in r- in T T T T Ovl CM rO H H H O H H H O CM CM T T 'T in

CM CM CM rH H H H CM CM CM CM CM rM CM CM CM CM CM CM CM CM CM H CM r-

^ o ι3l ^ - l H ιη (>ι o fl n N r^• N H ⁽Il v m H N O o n ιn o ^ o u ι!l ^ m ι o^ v ι⁾ w ^ o ιD m oo (n H ιn oo ιIl M n ^ 1J ri ^o tD r> in cΛ i— T in in o^ cn vo ro ro o in H in in oo cn in o T T CO CM r— H o ro cΛ H CΛ θ co vo o ro vo r- τ r- H θ H t— o r cn o co T CO co t- H in o oo vo r- ro τ cΛ vo τ oo cM vo τ (— ιn τ cM oo ro o vo oo oo τ vo o vo o oo vD in ιn cM vo cn ro cΛ τ cn n vo H θ ιn τ ro o ιn vo <Λ CM τ oo ro o ιn τ

H CM H CM CM CM T H CM O Cn oo r— VD OO CΛ OO CΛ CΛ I— r- <Λ OO O H CM r rO O O O O Oθ r- OO O H O O H H H H CM O O OO OO O H H CM CM H O O CΛ Cn CΛ Cn cn Cn en cΛ CΛ CΛ CO CO CO CO TO OO OO OD CO CO CO OO CO CΛ eΛ CΛ CΛ Cn cΛ CΛ CΛ CΛ CXI CD CO CΛ

VD ^ ^ ^ ^ ^ ^ ^ oι⁾ m (O ffl co o ⁽o os ι⁾10l <ll (J (Λ m o o o o o o o H H H H H H H ^J (^ι N l^l ( (ι (^ι n n ιo m to n ^ ^ » ^ v •»

H H H H H H H H H H H H H H H H H H H H H H Oⁱl CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM ro n ro ro ro ro ro ro ro oo ro ro ro ro ro ro n ro ro oo oo ro ro ro oo ro ro ro oo oo ro ro ro ro ro ro ro ro oo r^

Hl H H H H H H H H ⁽- Ptt D⁾ Oι D< ⁽H lH ftι ⁽- ⁽. Λ l, B; tt J J H J J J Hl ^j ω ω ω ω w ω w w co w cπ cα rø w OT OT ω w ω w w w rt^ rt, δj 23 ft f t f rtj pέ cϋ oέ Pέ Pύ Pϋ αi ω ω ω ui u cH' co co co c c co S ∑ ∑ ∑ ∑ ∑ fit fit fi fit rt! fit fit co c co c co > > >: >: : > > > > > >t f

> > > Cu i-H -ι αι e» αι α^j c co c c co co fi fit rt; fit fi fit

H CM H CM H CM H CM

< ffl U D „ fit cQ o α Q fit CQ o fit CQ CD O < CQ CD Q fit CQ CD fit CQ O fit z υ υ υ co υ o o z υ υ υ o o υ o z o o o υ o o υ υ o υ o z υ υ υ o υ o z υ o υ υ o o zoυoυozooCQυCDoQoQ r- co en o H CM ro T in vo t- co cn o H CM ro T in vo r- oo cn o H CM ro T in vo r- oo cn o H CM oo T in vo t— oo cn o H CM ro T in vo t— oo cn o H CM ιn ιn ιn Φ Φ Φ ^ ^ ^ ^ r- ^ ^ ^ ^ ^ cD oo ∞ co ω oo co co αι co crl σl σι m σl m m cIl m <Jl o o o o o o o o o o H H H

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T

00 rH

ΣoΣoΣΣΣ Σ ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ

EH H EoH EoHoΣ Σ EHoEHoEHoΣ EHoEHoEHoEH EoHoEHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoEHoHoEHoΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ EHoEHoEHoH EoH EoH EoHoEHoEHoEHoEHoEHoEHoEH EoHoHoEHoHoEHoHoEH o A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A

co en CM CΛ en T ro T Ch ro r— cΛ oo ιn cM CΛ r- τ H CM VO <Λ I— t- CM oo in m r- H ro T H [- H ro vD t- m vo oo oo τ T O CM 00 T O T

CO 00 O CO CΛ CΛ CΛ OO 00 r- H O CM ro T T T VO in VO in in T in 00 CΛ

H H CM CM CM CM CM CM CM CM 00 ro 00 ro ro ro 00 ro ro ro oo ro ro 00 CO ro O O O O O O O O O O O O O O O o OOO OO O OO OO O O O O O O O O O O O O O O o o OOO OO OOO OO eΛ t- o cM T O oo vo r- vo ro CM VO VO CO T t- O CO CM O O vo m vo cM H oo vo o cΛ CΛ ro in D VD T ro cM H CO H H O OOO OO O OO O O

H VD ro co oo vD ro m o vD co T rH T H i— in o o co vo eΛ o o^— o ~ —τ - o ~ c -M^■ H r "o o CM cn CM T T O in ∞ αa in H oo oo H co en vo en H

CM CM CM H O H CM in in cM CM O o cΛ oo cM ro

H H H co ro cn cM CΛ in co o ro cM CM CM rO LO co vD m o ro (- CM t- oo r- r- r- ro ro τ ιn . . r .- c vo H cΛ oo H < ^ι σι r oo H r- <Λ rθ H Cθ ι m r- vo ivθ vo o

H 000000 τ t- CO T T <Λ CO CΛ O <Λ H T T H vo cn m co m cn i— H ro o cM T Vo in r- CM cn ro t— τ ro H t- VD CΛ ro cΛ CM _'τ τ ιn oo oo τ oo oo τ r- vo oo in H in vD t- o H vo oo o o in m cM oo oo r- t- in t— o o in cri T CM T ro cn oo o cn o o r- vo o m H H O cΛ VD ro in o co r- ro m rH VD Λ CM H oO T T in in in vo iD co in in t— t— oo cΛ oo cΛ O H CM H CΛ oo cΛ oo oo r- t— co ιn τ ιn ro o H CΛ O H H CM O CΛ O O H CM rH CM O H O H O CΛ H O cn cn cn cΛ cΛ σ^ iΛ cn m cΛ m cn cn cn m cn cn o o o o cn cn cΛ cΛ cΛ cn cΛ cΛ cΛ cΛ cΛ cn o o CΛ O O O O O CΛ O O O O O O O O O O O CΛ O O

H H H H H H H H H H H H H H H H rH rH

^ ^ ιn ln ι ln ιn ιn ι ιn ιn Φ ^ ^ ^ ^ ^ ^ ^ ι» ω ω co co o co ω co co ω (» <Λ ^Λ m <Λ (Jl o^ σ^ o o o o o o H H H r-l H l H l

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM Cl CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ co n ro ro ro oo ro ro ro ro n ro ro to oo oo oo oo oo oo ro ro ro ro oo ro ro ro ro n ro ro m ro m ro ro ro ro ro r^ cn cn x x x x ri r r r tΛ cn tn cn n ui cn cn x x x x x x x x x x x x x x x t r r r r r r r et i^ H5 Hl H^ iH HH HH Hj H^ O O fi rt; rt; rt; rt; rt; fi fit EH EH H EH EH H H H EH EH H H H H H EH EH EH EH O O O O H H H H H H H H

H CM H H CM CM H CM CM H H

A CQ Q W S3 t fit CQ CD D Q fit m c Q i-H Q ω si a rt! CQ o o υ ft CQ CD fit 03 CD CD Q υ o z o o υ o o z υ o z fi υ o z υ o υ o z o o oo o o o υ o o o o o z O O O O υ υ o o co z υ υ oυ υ υ o o (oj T iinn vvou rt—— o ooo eσnι θ H CM ro τ m vo t- oo eΛ θ H CM ro τ ιn vo r— oo en o H CM ro τ ιn vD r- oo cΛ θ H CM ro τ m vD t— oo en o H cM ro τ m vo r- oo

H H H H H H H C CM CM CM C CM CM CM CM CM ro ro ro ro ro ro ro ro ro ro ^ T T T T T T T T T in in in in in in in in in in vo vD vo vD vo vo vo ro oo n oo oo o ro oo oo oo tn m n ro oo n ro oo oo n ro m ro oo oo oo oo n ro ro ro oo oo ro ro ro r n ro ro n

T T T T T T T T TT T TTT T T T TT TT TT T T T T T ^ T T TT T T T T T T T TT

00 VO oΣooΣΣoΣooΣoΣoΣΣo oΣoΣoΣoΣooΣΣooΣoΣΣooΣΣoΣoΣoΣoΣooΣoΣoΣoΣΣooΣoΣoΣΣooΣΣooΣoΣΣoΣoΣooΣΣΣ

© o ΣΣooΣoΣoΣΣ oΣoΣoΣoΣΣoΣoΣ Σooo o A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A , A A A A A A A ft A A A A A A A A A A A A A A A

Table 6

ATOM 4369 N VAL 3232 102.364 13.600 101.526 1.00 38.92

ATOM 4370 CA VAL 3232 102.391 14.441 100.342 1.00 40.39

ATOM 4371 CB VAL 3232 103.264 15.669 100.578 1.00 39.85

ATOM 4372 CGI VAL 3232 103.271 16.546 99.351 1.00 39.62

ATOM 4373 CG2 VAL 3232 102.736 16.437 101.775 1.00 39.18

ATOM 4374 C VAL 3232 102.957 13.582 99.221 1.00 42.03

ATOM 4375 O VAL 3232 104.005 12.959 99.384 1.00 42.84

ATOM 4376 N GLU 3233 102.267 13.548 98.084 1.00 43.41

ATOM 4377 CA GLU 3233 102.698 12.700 96.977 1.00 44.19

ATOM 4378 CB GLU 3233 102.249 11.268 97.253 1.00 44.16

ATOM 4379 CG GLU 3233 100.801 11.210 97.745 1.00 46.42

ATOM 4380 CD GLU 3233 100.302 9.798 98.011 1.00 47.74

ATOM 4381 OEl GLU 3233 99.245 9.660 98.677 1.00 46.48

ATOM 4382 OE2 GLU 3233 100.960 8.833 97.551 1.00 48.12

ATOM 4383 C GLU 3233 102.201 13.080 95.589 1.00 44.58

ATOM 4384 0 GLU 3233 101.077 13.537 95.418 1.00 43.85

ATOM 4385 N ASN 3234 103.066 12.876 94.602 1.00 45.20

ATOM 4386 CA ASN 3234 102.734 13.111 93.210 1.00 45.75

ATOM 4387 CB ASN 3234 103.476 14.334 92.615 1.00 45.13

ATOM 4388 CG ASN 3234 104.982 14.134 92.491 1.00 44.18

ATOM 4389 ODl ASN 3234 105.467 13.020 92.346 1.00 43.62

ATOM 4390 ND2 ASN 3234 105.723 15.233 92.520 1.00 43.12

ATOM 4391 C ASN 3234 103.152 11.825 92.514 1.00 46.39

ATOM 4392 O ASN 3234 103.416 10.828 93.173 1.00 46.09

ATOM 4393 N GLU 3235 103.235 11.852 91.194 1.00 47.69

ATOM 4394 CA GLU 3235 103.592 10.669 90.425 1.00 48.68

ATOM 4395 CB GLU 3235 103.195 10.907 88.975 1.00 50.55

ATOM 4396 CG GLU 3235 103.360 9.735 88.053 1.00 53.73

ATOM 4397 CD GLU 3235 102.929 10.088 86.647 1.00 56.51

ATOM 4398 OEl GLU 3235 103.437 11.103 86.115 1.00 56.67

ATOM 4399 OE2 GLU 3235 102.083 9.360 86.078 1.00 59.10

ATOM 4400 C GLU 3235 105.059 10.242 90.499 1.00 48.11

ATOM 4401 O GLU 3235 105.398 9.114 90.157 1.00 48.22

ATOM 4402 N TYR 3236 105.925 11.127 90.972 1.00 47.64

ATOM 4403 CA TYR 3236 107.352 10.835 91.034 1.00 46.82

ATOM 4404 CB TYR 3236 108.112 11.980 90.359 1.00 47.99

ATOM 4405 CG TYR 3236 107.695 12.162 88.924 1.00 49.09

ATOM 4406 CDl TYR 3236 106.387 12.517 88.596 1.00 50.10

ATOM 4407 CEl TYR 3236 105.964 12.578 87.272 1.00 50.72

ATOM 4408 CD2 TYR 3236 108.575 11.886 87.889 1.00 49.80

ATOM 4409 CE2 TYR 3236 108.163 11.946 86.563 1.00 50.77

ATOM 4410 CZ TYR 3236 106.859 12.289 86.264 1.00 50.58

ATOM 4411 OH TYR 3236 106.454 12.313 84.957 1.00 50.48

ATOM 4412 C TYR 3236 107.898 10.610 92.429 1.00 45.57

ATOM 4413 O TYR 3236 109.104 10.652 92.645 1.00 45.09

ATOM 4414 N GLY 3237 107.011 10.372 93.381 1.00 44.21

ATOM 4415 CA GLY 3237 107.468 10.159 94.736 1.00 41.97

ATOM 4416 C GLY 3237 106.448 10.529 95.786 1.00 39.88

ATOM 4417 O GLY 3237 105.378 11.048 95.482 1.00 40.72

ATOM 4418 N SER 3238 106.795 10.249 97.033 1.00 37.18

ATOM 4419 CA SER 3238 105.938 10.530 98.161 1.00 34.84

ATOM 4420 CB SER 3238 105.051 9.329 98.446 1.00 33.70

ATOM 4421 OG SER 3238 105.132 8.981 99.816 1.00 33.08

ATOM 4422 C SER 3238 106.806 10.788 99.374 1.00 34.34

ATOM 4423 O SER 3238 107.893 10.241 99.484 1.00 35.66

ATOM 4424 N ILE 3239 106.347 11.653 100.266 1.00 33.12 ιn ^ co o o

ΓO T I— H CM oo in oo cM O OO CM T T OO VO O VO CM CO I— r- oo H in oo in T oo o m vo cΛ H in o ro co T cn o vo in m r- vo o cn vo cn co T Vo

H oooo vvDD CCMM oooo ccnn oo rroo oooo HH oooo TT ccnn mm oo o O HH CCΛΛ min rt—- Tτ Oo vvoo oooo oo oooo rrθθ HH iinn ττ rr HH <<ΛΛ ττ oo i— I T T CΛ o cM ro o H in oo rr-- vvoD r— o vo oo oo oo T in ιn ιn ιn cM CΛ in ro oo cΛ o vo oo t- CM m H T T VD oo vo oo m ro o VD vo oo cM cn m ro vo in CM ro oo o r- co r- T CΛ o oo ro vo oo VD oo ro o oo H

O H O CM CM CO T in in VO T VD VO r- OO CO CΛ O CΛ O H CΛ CΛ O oo CM ro ro τ τ ro cM rH oo rθ H θ in m VD OO OO CΛ O O rH OO CΛ eΛ CΛ CΛ o o o o o o o O O O O O O O O O O O O H O H H O O H rH rH rH rH H H H H H H CM CM CM H H H H H { rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH rH r— m in o oo r— t— c— vo o o T CΛ in H in vo t- OO H VD H I- r- VD H in r- T VD CM OO o oo oo co cM CM cn vo T T oo oo in oo in o T H m cM H O θ H H θ vo ιn τ r- t- CM τ oo oo vo ro cΛ Vθ t- CM O 00 CM T H VD CΛ in VD H CΛ σι O O τ — \ CM i r-- uin oAoj v_o# cΛ t- CM O T H H in co o m o r- in cM O cn cM H τ vo cn o co co m τ ro ιn H r— OO CM I— CM - H o oΛ oo vD in H vo cΛ cM oo cn in cM m in vD in H CM H T VO VO CΛ CM OO T in H CΛ OO VO in oO

H OO rO T in H CM H H O CΛ CΛ cO CM H CM ro τ m ιn m ιn ιn cM CM CM CM θ cΛ o cM CM ro τ ιn cD CD r- r- a-ι oo cΛ ro rM ro cM CM θ o o o oo T CO T T o

N ^ cn ^ tf H ^ ιIι n v lΛ m H ln ιη ^ x m o h ln ιn ^ o ι)1 lΛ ^ ιn <J> al H N ι o ιn m ^ « ιJ1 H O ιJl f^ ^ o) H r- ol 1» H o o ιn ιn » H H ιo ^ nΦ ■» H O ι/l H (Il ιn H (ι ιJl c^ι ιB v ^ H * o oιo^ H a « N ^ v co ^ (^ι ^I) ^lJ ^ oo ^ ^r ^ o ^ (^|l ooN l O ιn ^. N lo C1 CIl CO o co o ol o ^o ^ ln ^ ^ π N H t^ ^t (Λ H (Λ ^o ιo ^•o <Jl ^ N l09 co oo ^ι ln n ιη ω ι n (0 (Jι ^ o ω o50 '^' ^ o ω π ω (l (O ι H ^ m Φ ^ v ιn ^ ln ιn ^ ln ιn Φ Φ Φ co ιD 'τ ( ιn f ^{• ι} l (0 ^ ιn ( ^ cι n ι ι ^ ^ v ιn N H ιη N ιη n ι * | H C O Λ co o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o cΛ cn

cn cn cΛ cΛ cn cΛ cn o o o o o o o o H H H H H H H H H H cM CM CM CM CM CM CM ro ro ro ro ro ro n ro ro oo oo ro T T T 'T T T T T T in in in oo ro ro oo o ro r T T T T ⁱTⁱ T T '-s' T T T T T T T T T T T T T T T T T T T T T T

CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM < CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ eo oo m ro oo oo oo oo m ro ro ro ro oo n ro oo ro ro ro ro ro n oo oo m oo ro ro ro ro n ro n ro oo ro ro ro oo m n

M U W U W W W Z Z Z Z Z Z Z Z W W W W OT W W OJ W W I-_H C_H P_H ^

H H H H H H H < < «< < S I B a a t- a X ϊ M t< H Eι H h ^ H ^ t< Eι H h h t< EH H . U U U e) ! l5 U θ Hl (H Hl

CM H H H CM CM H H CM H CM H H CM CM H CM ft ω o CD a it CυQ CυD QoQzoozo ft CυQ CυD ^Qυ Qz Mυ Wzυoz f CQ CD CD (( O U Q IH Q H N S f eq CD a ω ω A CQ O O O O z υ f O O O O O O z o υυ o o υ υ o o o o z υ υ υ υ o z υ o Z O O in VO r— OO CΛ O H CM rO T in VO t 1—- CCXOI CCΛΛ OO HH CCMM CCOO TT UU VVOO tt-- OCDO CCΛn Oθ HH CCM rCOO TT iinn VVDD rr-- OoOθ CCΛn Oθ HH CCMM OrθO TT iinn VVOO Cr—- OOOO CCΛΛ OO HH CM rθ T in VO r- OO Cn o

CM CM CM CM CM ro ro ro ro ro ro ro r roo rooo rroo TT TT TT TT TT TT TT ^^ TT TT iinn iinn iinn iinn iinn iinn iinn iinn iinn iinn vvDo vvoo vvDD vvoo vvoo vvDD VvDo vvoo vvoD vvoo rr-- tt-— t— r- t— r- r- t— r- r— oo

T T T T T T T T T T T T T T T

00 rH VO H rH ∑∑∑∑∑∑∑∑∑∑∑∑Σ∑Σ∑∑∑∑∑∑∑Σ∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑Σ∑∑∑∑∑∑∑∑∑∑∑∑∑Σ∑

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O EH H EH EH EH EH EH H EH H EH H EH EH EH H EH H H EH EH EH EH EH H H EH EH H EH EH EH EH EH EH EH EH EH EH EH EH EH EH EH H EH EH H H EH H H H EH EH EH o st rti ft f fit ft fit rt; rt; rt; rt! κt rt; fit rt! ft rt! fit rt; κ rt; rt! fi ft fi rt! fi fit rt; ^pt rt; fi fit fit rt; fi fi rt! fi fi rt^

rt rt

1- ro o CΛ H T ro m H O T CM I— Cri CM H VD oo oo r- cn cn o oo r- m o cn vo in oo H T in oo T oo in H t— in t— O H H O CM VO OO CM H OO OO T Γ- CΛ VD rs >- *;> vD H cn vo o cΛ cn cM r- H ro en oo o ιn τ ιn π cΛ cΛ vo ιn σ^ co t— c» vo cΛ θ CM oo vo cM CΛ CM τ o oo cn cn cM in o o τ cΛ o ro ιn co ιn oo τ ro o o ■o

«1 oo t— i— oo cn t— t— t— t— cΛ t— oo cn co vo ιn vD ro ιn ιn ιn ιn τ ιn oo co oo [— o ro cΛ cM ro T O CΛ O O O OO Γ- vD VD oo t- H H H τ ιn cn τ ιn m m vo

CΛ & CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM OO rO rO T T τ oo cM ro oo oo cM CM (M CM CM CM ro ro ro ro ro oo ro oo ro ro ro f OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

H OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

U

PM rH rH rH rH rH H rH rH rH rH cM co o r- oo H CM O t— eΛ cM vo σi co oo o H co o in o m cΛ o cΛ o oo cM in m o o t— oo r- oo co oo oo cM vo cM co oo ro co H T o m oo cn in r- oo vo ιn Φ ^ ^ ^ ( ω ιn ^ ^ N Φ ιn ^ι (» Φ ln ^ σl ( H ιη ιn (O N (Λ <Jι ^ (Λ (^ ^ Φ O βι ω (N c^ι o ^ o co ι^| (^,) N O ^ι ιn v ιo H r-- [-- v ω o ιn N H ι ι ιn ι Φ n o M n ^ n m (0 ( co ( Φ H Φ H O oo ln Φ ^ Φ ^ ιn w ιΛ M n ln ^ ιn ol H (^ι ^ ^ ιn Λ o ^ H o m r-^• Φ ln o o m H H N n ^ in ^ io ^ ^ v in 'i' i i ω ^ iii iJi H iii Λ αi o H H O O O O N n π ^ ^ m n ^ in v Φ in i ω αi ∞ m oi oo ^ cfi

CM CM H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM n CM CM CM rO rO rO OO OO OO rO rO rO OO rO rO ro m H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H eo n Λ ιn ιη O in oo O ιn vo CM CM

(Λ co vo cM oo oo m H O oo ro cM t— CM CM cn co cM CΛ m τ r- cΛ H CΛ τ cM ro co ro τ vD ro m H H in ιn ro cΛ T H o αo o in i— oo cM Vθ vo σ> co τ ιn oo CΛ oo τ ιn ιn vo σ^ cΛ in cM t- iΛ τ cn oo cM co cM co oo o vD ro <Λ vo cΛ H τ τ r- o ro o o cM in <Λ o ro H O OO VD CΛ O t— O O O OO CΛ T O CΛ O O H oo cn cM cn ro o r H H CΛ CM r- θ H r- co r- H CΛ τ τ r- r- cn cM θ CD ιn τ oo ro cM H CM θ co ιn o o ro oo oo ro ro τ ro cΛ o o H rθ H r- cn o r- t— ιn cΛ oo cΛ cn o o H oo oo oo r- co τ ro τ vo m vD VD r- r- co ιn ιn τ oo cM H H CM θ τ ιn oo τ ιn vo r- r- oo cΛ cΛ co cM θθ ro oo cM ro -τ cM rH ro cΛ cΛ cΛ CΛ cΛ cn cn o o o cn en cn eΛ cn cn en cΛ cn cΛ cΛ cΛ CΛ cn en cn en cn cn cΛ CΛ CΛ cn cΛ cΛ cΛ cΛ cΛ cΛ cΛ cn cn cΛ cΛ CΛ cn cn cn c^

in in m in in vo vo vo vo vo vo vo vo f— c- r- t— t— r- t— CO OO OO OO OO OO OO CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ O O O O O O O O O O O H H H H H H CM CM CM T T T T T T T T T T T T T in in m in in m in in in in m in m in in m in in in m

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM N co n ro ro ro oo oo ro ro ro ro n ro ro ro n oo n ro ro ro ro ro ro oo ro n ro m ro ro n oo oo oo oo ro ro ro ro m

D D D D D Cu a- CH u H CH CH C H-l HH H Hq H^ H^ Hq ^j J H^ H^ J HH J D D D D D D a D D O O O O O O O O O O O tf ω ω ω cd ω c cg c co c c cg c rf fit rti fi fi fi fit fi fi fi fi fi fit δ

H CM H CM H CM H CM H CM H CM

CD Q Q fit cQ o a a z fit CQ CD O fiot CυQ CoD CoD C O Q CQ D Q ω SI a o υ o υ o z υ υ υ o o υ o υ υ υ υ υ o oozo ctυQoo ω X X fit CQ O o o υ o z υ υ υ υ z o z z o o z O O υ o z o o

r— ro VO oo σι τ oo M ∞ τ cΛ CM θ cx) co vD Λ vo cn vo ιn r- ιn cΛ ro cn cM cn o τ τ cM ro ι- r- oo cΛ H oo oo τ oo τ o oo r- CΛ H CM Γ- m m cM cM T CM O t— O

<s (^ι ω ιo ι ι ιx) ^ ln m H ^J ω lO lJ> O Φ ln W H Φ O l ιn σι ^o u Λ N Φ ιo ^ H ^ ln ol ^ m o o m ω ( « co ιn N ^ lI ^ (O co ^ a m cn

© A

© ■C ιn ιn r- r- cΛ H co cM τ ιn ιn ιn o σ> cΛ CD r- cΛ co co oo oo σD τ τ oo n cM CM ro θ H cn c» r- cΛ in vo cΛ cΛ cn cD vo τ cM

CΛ ro ro oo ro oo τ τ uθ ιn ιn ιn uθ τ ro n oo ro ro τ τ τ τ τ ro oo ro oo co ro ro ro ro cM CM CM eM CM CM

H -f oooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

⁽J

PM

H T CΛ OO CΛ CΛ OO T rO T rO CO H H CD O r- VO OO CΛ OO H T CΛ T O in θ T in H OO O CΛ T CO r- ιn CD CM CΛ CΛ T T rθ τ rθ m H O T H OO CM Cn

CM in cM θ cn cM H ∞ CD CN τ ∞ CM in cM CM Co r- o cn ιn cM ro oo o co vD CD -θ r- rn ro ro o τ ro o φ m <D Ol ^ o m ιO ( o n N N O '^' Φ oo o ^ Λ c^ι ω ιn ffl N o <; N o ^ w (^ ^ ^ ω ^ ι^| v <Il Φ (η oo H Φ N o o ιI) H ι eo (Jl ^^ αι H ( O H H o i i in in in

H H HH HH

T i T CM T T H OO m O T T co T H o m o vo cM co r- in co r- cΛ oo ro H t- cΛ ro cM cn m cM oo H oo vθ H CΛ [— o cΛ in co r- cΛ ro -n cM CM τ ro cM τ ro o tΛ in oo cΛ θ (- m o m r- in vo H co H C CΛ cM r- H oo H H i O CM Γ- VO OO OO T CM T in T CM CM OO T T in CΛ CΛ OO OO O Cvl OO VO O r- H in o oo H H H t— H cn oo cn OO T O t— H OO T T OO H rO CM in OO CD T OO r- in cn cM O oo oo o vo H in oo r- H in oo vD τ ιn oo o cn cΛ oo co r- ιn ro rM CM CM H H θ co co r- vo vo o θ H θ H θ H H CM ro cM <Λ oo oo <Λ r- r- oo vD vD ιn τ ro cM in τ oo cM CM CM oo ro ro o o cn oo vo r- t— t-

CM CM CM CM CM CM CM H H H H H CM CM CM CM CM CM CM CM CN CM CM H H H H H H H H H H H H H H H H H H rH rH rH rH rH rH

CM cΛ cΛ H H t— oo cΛ oo o r— in vD t— oo cM cn co cM ro <Λ CΛ τ cD <Λ τ cn ιn o cM co cn oo co H r- r- H σι ιn ιn τ cM H H τ t— CM r- o oo vo o oo cM in τ H T in cM VD T t— CM τ τ ιn cΛ o r- ro ιn H θ θ τ oo r- oo tn cM τ r- in OO O T VO VO CΛ T OO O T CM VD H OO VO VO O OO CΛ t- in OO rO CΛ T CM OO O O VO co T H H T iD m cn in oo cΛ cM m r- o oo o in t— CM vo ro oo rH T H H in r- oo oo τ ro oo m m cΛ CM CΛ cn τ cΛ θ vo m cΛ θ oo vo σ> <x> θ ιn t~- oo τ

CM H CM H CM H O O O H H H CM OO CM CM CM O CΛ CO t- OO VO rO CM T m T in CD OO CM rO CM H O O O CM OO CM CM CO OO OO T CM O CM H CM H H CΛ OO t— cn cΛ cΛ cΛ cΛ cΛ cΛ cΛ cΛ cΛ cΛ cn cΛ cn cn cn cn en oo oo oo oo oo o cΛ σ cΛ CΛ σ^ <Λ cΛ CΛ CΛ cΛ cn cn cn cn en cΛ CΛ cΛ cΛ cΛ cΛ CΛ c^

CM CM CM CM ro ro ro ro ro ro oo r ro rO T T T T T T T T T T T in in in in in in in co vo vo vo vo vo vo co t- r- r— t— r- t— r- r- oo oo oo oo oo cn cn cn ιn Ln ιn ιn ιn ιn ιn ιn ιn ιn Ln ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn Ln ιn ιn ιn ιn Ln ιn ιn ι^

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ ro ro ro ro ro oo ro ro ro ro ro ro ro ro m n ro ro ro oo ro oo oo oo ro ro ro m ro ro n o o o o ^tΛ co co co co co co co co co o o o o o o o o cD o o o o o o o o ω ω ω ω ω ω i-H ω D D D D D D D D z z z z Z fit fit fit

Oύ Cύ ύ tii r r rH rH rH rH rH r rH Cύ Cύ O^ Oi C^ Cύ Cύ Cύ Cύ Λ Cύ l^ Cύ c- -ι CH CH X x a: x aH HH H a; κ aH 3 rt; fi < rt; rt; rt; fi rt! f HH M C c a4 CH Q, H H

CM H H CM H CM CM H H H CM υ CQ CυDooz fotυCQ CυD QoQzυω rz-H <CQCDQUN D-!-r- Q fit CQ CD υozooυυzυzz fit CQ CD O Q υ o o o o fit CQ υ ozυooυoo υ υ υ o υ υ A CQ O Q Q o z υ o z Ao CυQ υ o z υ υ

^ ιl) m o H N ⁽O v ιo ) C^ O H N t rr ιn ^ ^ o3 m o H N ( fl ιil ^ ^ o30l O H l l ^ι^ι ιπ ω oJ m o H (^ι ιη ^ ιn ^ ^ co ol O H c^ι ro ro ro τ τ τ τ τ τ τ τ τ τ m ιn m m tn m m ιn ιn m vo vo vo vo vD vo vo vo vo vD [— r— r— r— t— r— r— t— t— t— OO OO OO OO CO CO OO OO OO OO CΛ CΛ CΛ in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in in i^

^_ι -^Jt ^i ^-ji ^i ^ι Kf Kf T ^f ^f ^f ^f ^f ^f ^f ^f ^f Tf ^ ^ ^f ^f ^f ^ f ^ f Kf Kf Kf Kf ^3* ^* ^f ^* ^* ^f ^* Kf Kf ^* Kf Kf ^f Kf ^3* "S* Kf Kf Kf Kf Kf Kf ^3* ^*

00 rH VO rH rH o ΣΣoΣoΣoΣoΣooΣΣooΣoΣΣooΣoΣΣoΣoΣoΣ Σ ΣoΣoΣoΣΣ © ooΣooΣoΣ ooΣoΣoΣoΣooΣΣoΣoΣoΣooΣΣoΣoΣoΣooΣoΣΣooΣΣooΣoΣΣooΣΣooΣoΣΣoΣoΣoΣo

O A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A it

t- o O 00 LO rH 00 CM in Λ T vo m r- vo co -n cM T CΛ r- CΛ o ro cM in O vo r- CΛ 00 r- cn in o t- vo ro ro o co cΛ CΛ in rO T vo oo r— CΛ H CΛ oo m t— T

JS H i-H CΛ ro in r- ro O H VD CΛ CΛ CΛ H 00 O CM in in τ r0 CΛ r- T CO T CΛ cn o T vo cn T CM CM CM r- CM VD M rH CM t- CM 00 in oo T T ^ ω I ^

© •o o I— ^ Φ ^ » ιn n ^ (_ ^ ^ ^ ιn ^ ^ ^ ω ffl ffl c^ι co oo ^ co (Jι σ^ o H ( '^^ (O ιn ^ r-• r• oo Φ ι ^ oo r t—- co ω oo en

CΛ CM CM C CM CM CM CM CN CM CM CM CM CM CM CM OM CM CM CM CM CM CM CM CM CM eM CM CM CM CM CM CM rO rO rO C^ ro oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

Hυ oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

P HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHH t— oo vo o oo en oo i— ro t~- t— oo t— H τ vo m oo H <Λ o cM co m τ en cΛ CΛ τ t— r- CM CΛ H CM VO CM H T CM OO OO OO OO VO O <Λ vo o cM θ vo σι t- <Λ τ r- o oo o θ H θ H co co cn τ oo cM ro cn o cM ro τ τ cM τ cM in t— τ oo m m co co oo cn cM cn H θ CM θ "3ⁱ cΛ co H τ cΛ H oo cn cn t— in co cM CD co t- cM θ cn ιn ιn <Λ τ ro t— ιn αo co cM θ ιn cr* cΛ θ ιn ιn H i- H CM i— (Λ oo cΛ oo vo σi vo σ^ t— o in o oo oo ro in cM H in o H T VO Cn m r- CO T CM rH

N N ^ v ω Φ ^ in ^ i N v in ui ^ ^ co βi co ω m Λ Λ H H H m iη m fO iη n N ^ in Tj fO M o o Φ r' ^ o oi iJi o o ^ ιn ι m ιn m ιn ιn m ιn ι m n ιn n ιn ι n ιn ιn ι ιn ι ιn ιn Φ Φ Φ Φ Φ Φ Φ Φ Φ r- Φ Φ

HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH

H O CM r- O I— O CΛ CM O t— 00 H r in t— <Λ t- CΛ O r- O OO O VD H CΛ T O Vθ rθ H t— <Λ r- CΛ t— r H CM H OO in O O CO H o r- co o σ> ro τ vo H vo o Λ T CM vo H in c CM ∞ CM CD T ro vo t- in σ^ cM T O oo t- oo H VO VD oo co oo in w in Λ in in T OO T n c CO T o oo in vo in oo T oo m oo

T in τ OO T t- CM rθ O VO T VO t- t- CΛ CM CO VD CΛ O in CΛ H I— (Λ OO O OO CO H H H Ln in T CM rH OO r- CΛ rO H O O CM CΛ O T CM CM Λ OO T in O CΛ

C0 in VD ιn m τ VD V0 VD T T 00 t- 00 r- Crι CD r- 00 VD V0 T T CM 00 00 T 00 f0 m V0 in CM H CM H H H O O CM H CM O O O O H H O H H H

I I I I I I I I I

00

T oo H in oo oo co co cM CΛ oo vo H H in cn co in t— θ H CΛ τ co en H CM in τ cM τ H θθ oo H τ ιn O in cΛ CΛ H CΛ m OO r- H H CΛ O I— in VO CM T H H θ H cn r H oo cn m vo ιn o cn co τ H cΛ τ ιn o _U cIM r_I-— τ -^. cCM cio_'i τT T CM T rO CO CM T O VO OO OO Cn o cM T CΛ VD ro r- in oo H T Λ in ro vD in oo cM in vo r- cΛ ro r— cn in cΛ cn oo oo H CM oo cΛ H T CM in OO H VO VD VO t— OO VO VO CM in CM CM OO O H t- H CM '3' ro ro oo cM τ m cM CM in vo r- vD r- cΛ ιn τ cM

^ σ^ oo ^ o o H CM oo oo τ τ ro cM co τ τ ιn τ (^ cιi ro r cM CM cθ H H o eΛ o c» cM CM co co ιn ιn co co vo oo τ oo ro cM H CM τ τ ιn vD [— r- co co co rø oo cn σ^ eΛ cΛ cn cΛ CΛ CΛ cΛ cn cΛ cΛ CΛ cn cn cn en cn cn cΛ cΛ eΛ cΛ cΛ CΛ co cΛ OT CΛ CΛ CΛ CΛ cn cn cΛ cΛ c^

«. w. o o o θ H H ιH H H H H H CM CM CM CM CM CM CM ro ro ro ro rθ τ τ τ τ τ τ τ τ ιn ιn ιn ιn ιn ιn ιn ιn ιn vD VD Vo vD VD VD VD r- r- r- t— t— t— mm Φ Φ Φ ΦΦ Φ Φ ΦΦ Φ ΦiD Φ ΦΦΦΦΦ Φ ΦΦ ΦΦ ro ro ro ro oo co ro ro ro ro co oo ro co ro m ro oo ro ro ro ro oo ro ro ro ro ro ro ro m

33 ^H >π >^H >^H D D D D rD D D D O O O O O O O fit ft fit Z Z Z Z Z Z Z Z co co co co co co co co co pH PS t-i oS ctf PH PH i-l rl rl rl rl r r ri ri ω a ω ω a ω ω ω al ai t c e & t r ri cn cn w w v⁾ w w u> x x x x x x x x x x x x x x x x A fit ft CD CD CD CD H^ HH HH ft ft A A h3 ₎j Hl ^ j αι D_l Qι [. |- l- l. c( A A A < r r A r A rl r rl rl fr< tH {H fH tH ζH tH > > > i> t> > υ o z υ

M v ιn a ^ co ⁽^l O H N fl fl ln Φ ^ ι- o> O H (^ m v ιf) ^ ^ oo ol O H ( ( ^ ln ^ oι ιJι o H ( ( '^ ln « ι^s co (I\ o H ι ι ^ ln ^ _

CΛ CΛ Cn CΛ CΛ Cn CΛ O O O O O O O O O O H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM rO rO rO OO rO OO rO rO OO rO T T T T T 'T T T T i m m i m i in vci Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ vo Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ

^3* Kf Kf ^* ^3* ^3* ^3* ^3* ^3* ^3* ^3* ^* ^* Kf ^3* ^* ^* ^* ^* ^3* ^3* Kf Kf Kf Kf Kf Kf ^3* ^* ^3* ^* ^3* ^3* ^3* ^3* ^3* Kf Kf ^* ^ Kf Kf ^* ^* ^* ^* ^* Kf ^3 K ^* ^3* Kf ^* ^3* Kf

00 rH

∑oo∑o∑o∑ ∑o∑o∑oo∑∑o∑o∑oo∑∑oΣo∑oo∑o∑o∑ ∑o∑oo∑ ∑o∑oo∑ ∑o∑o∑o∑o∑o∑oo∑∑o∑o∑o∑oo∑o∑∑o∑o∑o∑oo∑o∑∑oo∑∑oo∑o∑ΣoΣoo∑∑o∑oo∑∑o∑o o A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A

r- ro <s vo in m in cM oo cM O ro oo ro in r- T O Co co τ o cM cn cn H ro cn τ o oo vo ιn t- ιn vo n r- ιn r- r- ιn ιn cΛ H ro cΛ rθ (Λ VD i- τ ιn ro vo τ cD vo vo

© vo τ vD vo σ> r- oo o ιn cD m ιn o r- o CD OO T I— T in OO CM OO T rO rO CM OO OO T CD CM H CΛ CM VO OO t— VO T IΛ CΛ 00 r- rH 0O 0O VD ⁽Λ τ 00 H VO CM © •Si

CΛ CΛ CM CM CM CM OO T ro ro cM OO T T T T oo rO T r- ro ro cM CM CM rO T CM H CM O O O O O CΛ CD CO CΛ rH t— Λ OO CΛ Λ I— in m vD vo vo in in ro Kf Kf Kf Kf ^3* ^ * Kf Kf ^* ^ * ^ * Kf Kf ^* ^3* ^* Kf Tf ^ * Kf Kf T T T T T T OO oo co eO T T T T Oo oo oo oo ro ro ro ro ro oo υ OOOOOOOOOOOOOO oooooooooooooooooooooooooooooooooooooooooo OOOOOOOOOOOOOO oooooooooooooooooooooooooooooooooooooooooo

PM

^ _lfl ιJ^ ^ w v o oo ι ιo « n oo ^ t o H l _lr_l V _ln o N t01» o o o ι» Φ ( Φ » (Jι ( o co oι n o o ι^,) lo <ι^ι o c1ι ^_' '^ H oι) oo ιl ^o _ p-i H H H o m cn r— o r- ιn τ τ H vo oo cM ro m <Λ in cM θ t— CM in cM vo vo r- cM co oo o cM θ CM CM oo m m cΛ cM CΛ vo r- τ oo t— CΛ OO OO H OO VO OO O T I— r- H CM ro oo T O in oo T in cΛ in H VO T O VD T H T Oo t— o in r- vo oo in oo in ro H T T Vo cM H O in H H H in cM oo t— m oo o o cM cM

CM H CM CM OO CM T T VO Γ- OO VO T T OO OO CM H H O o iΛ cn r- vo vo vo r- ιn m m ιn τ ιn cD τ co oo cM H θ <Λ oo oo t- o o o cΛ θ H CM oo oo τ r- t— t— t— t— t— r- t— t— t— t- r- t- r- t— t— I— I- r- r- t— VO VO VD VO VD VD VD VO VO VO VO VO VO VO VO VD VD VD VD VD in in in in VO VO VD in vO VO VO VO VO VD ro oo oo cTi co oo cn in vD o oo vo cM t— o cM H O CM o t— ιn τ cM CM oo o H H in co cM τ vD CΛ in H CM ro o ιn o cM CM θ ro t- co in cM vo in oo r- o o ιn τ ιn τ ιn τ cM ro oo cΛ CM vo vo ι— r- H t— OO O T H CM Γ- o in o ro o cΛ oo vD OΛ r- vo cM O oo T T ro ro oo in oo o O CM CM H 00 VO O t- CM H CΛ CM Vo cM r- cn o cn H H o m r- vD o vD co r- ro vD t— oo cM t- oo in o oo oo co m in oo oo vo vo oo r- t— vo en co CM rH ro OO T O ΓO O CO H VO CΛ

H CM ro T CM H H O O O O H CM CM 00 O H O H O O O H O O H CM H H CM H CM H O O O O CO CM T in VO VO -O VO in m I I I I I I I I I I I I I I I I I I I I I I I I i— cM T Vo vo o oo cΛ CM oo in t— r- oo en ιn τ r— CO O t- H O H O t- t— cM t- ιn H CM r- vD oo cM vo ι- oo o τ m cΛ vo co H ro oo co H o oo in ro

H VO rO O H VO CΛ Cn cM H CD Cn in O rH T 'T rO H rO H O o m cΛ co in cΛ T oo o τ ro cM H cn cM H r- CΛ r- CM t- t— vo τ ιn r- oo τ oo t- o ιn cM cΛ cΛ o vo cM r— τ r- r- r- ιn H CΛ H τ o ro τ m oo oo CΛ T CΛ T CO OO in cO O oo cM T O CΛ r- o m oo H co cn αo H t— cΛ θ CD r- m oo cΛ ro θ H τ ιn

CO 00 00 CΛ CΛ CΛ O O H H CM CM CM rO T T in OO rO oo τ oo τ m vo ι- r- ro cM 00 H O H CΛ CM CO H H CM CM CM 00 CM O VO CΛ CΛ CΛ CΛ CΛ CΛ O O O O O O O O O O O O O O O O O O O O O O O O O O O O O cn o o o O O O O O o o os

r- OT ∞ ro cD ∞ cn cn cΛ cn cΛ cn cn cΛ o o o θ H H H H H H CM CM CM CM CM CM CM CM co ro co ro co co ro τ τ τ τ τ τ

Φ Φ Φ Φ Φ Φ Φ Φ Φ ^ ^ ^ ^ r- ^ ^ ^ ^ r- ^ ^ ^ ^ ^ r- ^ ^ ^ ^ t-- r-- ^ ^ ^ ^ ^- ^ ^^,• r^■ ^- r-^• ι-- r^■ ^ ^ ^ ^ r- r• ^

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^ ro ro ro ro ro ro ro ro ro ro ro ro ro co co ro ro ro ro eo ro ro ro cn ro ro oo ro co ro ro oo e^ rt! D D D D D D D D ^{H H H H} Cu θH CH CM -, PH Z Z Z Z Z Z Z Z H3 HH HH HH H^ H^ H^ D D D D D D D D D ω

Hπ w ω w cd ω ω ω ω HH HH HH HH Cd w ω ω ω ω co co co co co c co ω fi^ fi( HH H^ H^ HH H HH H^ HH θ θ θ c co co o rt; fit rt; rt; rt; κt fi fit > > > > > > > o o o o o o cH CH αι c- CH θ^

H CM H CM H CM H CM H CM H CM

A co CQ Q Q fit fit CQ o Q CD Q Q fit CQ O O ft cQ C Q ω ω fit CQ CD Q Q W CJ o z O O o z ft o A C

O υ υ υ υ o z υ υ o z υ υ o υ o z υ O υ O Z υ o z O O O O o z υυυoooυo υ υ υ υ o o o

r- ro S VO in H H in cM cn oo in m r- H in oo H ro o H vo o r- m vD oo o τ ιn vo ιn vD o vD oo o r- oo τ oo cn m [- oo cΛ cn m oo cM cn τ ro o H ro ιn o ro <Λ o CM CO CD C~ CΛ CΛ H θ rr) eΛ O H T VO VO in α3 in θO H CO in θO (Λ T CΛ ∞ C» CΛ r- θ rΛ CΛ CN T r in θ r- H CO r H CM VO C» CΛ r^ β 5 -S» co T in ro cM Oo cM H H H CM CM M ro H C CM C t— O H OO H H CΛ I— vo m oo t— oo c— co vo vo vo in vo t— oo cn co vo in in t— CΛ T T T T T CO VO

£? OO rO rO rO rO rO rO T T tO rO rO OO OO OO OO OO OO rO OO OO T T rO rO rO CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM

H oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

<J oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

PM

H HHrHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ro o o r- r- CM θ H τ oo cD o τ cΛ H in τ vo oo t— o o vo oo τ cΛ τ <Λ m m oo o t- H co o t— in vo in vo oo r- o in vD O T oo r- ro H vo in r- cM

O T OO CΛ OO VD VD CΛ VO T CM O I— 00 O H O VO H O T CM T OO in CΛ CM OO OO t— 0O 0O CM 0O CΛ τ t- T CM T C^"M: rH H CM OO H t- VO t— H T OO O oo cn cn τ oo cΛ τ o cM θ m cM in o ιn oo ro o ιn H in H in vD r— t— oo in m o CΛ T T cn oo T c co co cΛ vD H CM cn co m oo in r— in ro H T CM CM co cn

T OO t— t— VD in in OO CM in VD T OO CM CM T T H O CΛ OO t— VO in CΛ CΛ Cn oO CO CO O VD VO VD T T CM O CM H O CO T in tO OO T T CM CM H O σi t— VD vo in in in in in in in in in in in in in in in in in in - ' T ' -T T T 'S' T in T T T T T T T T T T 00 T T T T O ro r

H H HH H H H HH H H HH H H H H H H HH H H HH H H H H H H HH H H H H T VO CM T ln ιη ιn o m ιn m ιn m τ ro cN ro vo vD i— oo co eo en H ∞ co vD VD in ιn ιn cΛ σι θ H CM τ cM H H CM CM CM CM H CM ro τ ro ro τ τ τ vD vo oo vo ιn r- t— OO OO CΛ

H H H H H H H H H H H H H H H H H H H H H H H H rH H H H H H H ro ro

CM CM

M ιo

^ m o ω ro o3 fll σl m ^ o3 ^ oo σl ι» ^ ^ ^ Φ ^ lΛ ^ Φ ln ^ ^ ffl ^ ω ^ ι> Φ Φ ^ ^ ιn lfl ^ <I^, ln ll Φ ιn Φ ^ ^ ^ oo ^ ^ Φ r- Φ cn cn o cn cn cn cn cn cn cΛ CΛ CΛ cΛ CΛ cn cΛ CΛ CΛ cn cn cΛ cΛ eΛ cΛ cΛ CΛ CΛ cn eΛ cn cn cΛ cΛ cΛ cΛ cΛ c^

iΛ iri i i W ^ ⁱo ⁱo ⁱo io io ^ h ^ ^ m ω ffl m oj iii ffl i- ∞ oi oi m σi oi m ^ji o o o o o o o o o o o o H H H H H H w ii N N N i— i— i— r- t— i— r- t— t— r- r- t- t— r— r- r- r- i— t— r- t— t— t— r- r- t— t— t— t— t— t— Γ-- Γ-- OO OO OO OO CO OO CO CO OO OO OO OO OO OO CO CO CO OO OO OO OO O CO

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM ro n ro n ro oo ro ro oo ro ro ro co ro ro ro oo oo ro ro ro ro oo ro ro oo ro ro ro oo oo ro m n m oo ro ro ro ro ro ω ω ω π H H H EH cH fr hi cn cn n n n Ω Λ cn n cn tn Λ cn w cΛ r rl rl rl rl rl A C cύ ύ cύ & &

K ac ffi ω ω ω cd cd t-3 tl3 l-a >H H >H ^ >H >H >H >H > < > >H >H H rt! rt! rt! ft rt, fit fit H >H >H >H >H >H < H > >H H H W

CH C-I I-H Σ ∑ Σ ∑ ∑ Σ υ υ υ υ υ υ HH HH H3 H^ IH j H5 HH HH > > > > > > > H EH H EH EH H H EH EH EH EH H CO CO CO CO C C fit rt! A A A

CM CM

SI fit CQ Q ω A co o fi cq o ω s) Bt Q o cD ft CQ CD Q U Q ti- N -C f o o a O O υ υ υ co o υ o z υ υ o o co z o o o o o s o o z υ o o o o zυυooooυooooz fit PQ CD υ υ o υ o z υ υ υ o in vo t— co cΛ O H CM oo T in vo t— oo cn o H CM ro T in vo t— co cn o H CM co T in vD r- co cΛ O H CM CO T in vo r— oo cn o H CM rO T in vo r— oo cn o

O O O O O H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM ro ro oo oo oo oo oo oo ro ro τ τ τ τ τ τ τ ^i' T '3' in m ιn ιn ιn ιn ιn m m ιn vD r- r- r- r- r- t— i— t— [— r- t- t- r- i— t— r- t— t- r- rr-- rt—- ii—— r t—- r r-- r- r- r- r- t— t- t- t— t— t- t— t— t- t— r- t- r- t- i— r- i— r- r- r- t— t— r- t- t- t— r- t—

00 T T T ^3* K ^3* Tf Kf Kf Kf Kf Kf ^* Kf Tf *^* ^f Kf Kf Kf Kf Kf ^* ^* Kf ^3* ^* Kf Kf K Kf Kf Kf Kf ^* Kf ^3* j' Kf Kf Kf Kf Kf K K Kf Kf Kf rH VO

© ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ o o oooooo o Σ Σ Σ Σ Σ Σ O O O O O O O O O O

EHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHo o ∑ΣΣ∑Σ EHoEHoEH EHoEHoEHoEHoEHoo ∑ EH EH oo∑∑o∑oo∑∑oo∑∑∑ oΣ Σ Σ Σ Σ H EH EH H EH EH H EH EH EH it fit fit fit rt! fit fit fit fit fit ft rt! fit fit fit fit fit fit rt; fit fit '-t rt! < rt: rt! fit fit rt! ft fit fit A A A A A A A A A A A A A A ft fit fit ft fit fit ft ft fit fit fit

Table 6

ATOM 4761 OD2 ASP 3282 98, .719 18.127 137.717 1.00 28.43

ATOM 4762 C ASP 3282 99, .096 18.357 140.673 1.00 23.14

ATOM 4763 O ASP 3282 100, .230 17.872 140.629 1.00 23.70

ATOM 4764 N PRO 3283 98, .867 19.584 141.173 1.00 21.96

ATOM 4765 CD PRO 3283 97, .607 20.287 141.441 1.00 21.41

ATOM 4766 CA PRO 3283 99, .988 20.391 141.634 1.00 21.24

ATOM 4767 CB PRO 3283 99, .316 21.668 142.111 1.00 20.49

ATOM 4768 CG PRO 3283 98. .043 21.698 141.376 1.00 19.84

ATOM 4769 C PRO 3283 100, .673 19.652 142.775 1.00 22.00

ATOM 4770 O PRO 3283 100, .019 18.974 143.569 1.00 22.58

ATOM 4771 N GLN 3284 101, .985 19.787 142.862 1.00 21.77

ATOM 4772 CA GLN 3284 102, .731 19.100 143.894 1.00 22.25

ATOM 4773 CB GLN 3284 104, .193 19.519 143.817 1.00 22.11

ATOM 4774 CG GLN 3284 105, .167 18.363 143.885 1.00 21.39

ATOM 4775 CD GLN 3284 104, .727 17.168 143.070 1.00 20.44

ATOM 4776 OEl GLN 3284 104. .308 17.294 141.927 1.00 21.08

ATOM 4777 NE2 GLN 3284 104. .839 15.993 143.659 1.00 22.03

ATOM 4778 C GLN 3284 102. .138 19.397 145.259 1.00 23.07

ATOM 4779 O GLN 3284 102, .113 20.541 145.696 1.00 25.06

ATOM 4780 N PRO 3285 101, .625 18.365 145.943 1.00 23.82

ATOM 4781 CD PRO 3285 101. ,402 16.995 145.447 1.00 23.47

ATOM 4782 CA PRO 3285 101. ,022 18.529 147.266 1.00 24.63

ATOM 4783 CB PRO 3285 100, ,077 17.342 147.355 1.00 23.30

ATOM 4784 CG PRO 3285 100. .879 16.277 146.685 1.00 23.16

ATOM 4785 C PRO 3285 102, ,052 18.501 148.379 1.00 25.09

ATOM 4786 O PRO 3285 103. .148 17.968 148.206 1.00 25.46

ATOM 4787 N HIS 3286 101, .700 19.080 149.518 1.00 25.38

ATOM 4788 CA HIS 3286 102. ,610 19.062 150.635 1.00 25.96

ATOM 4789 CB HIS 3286 103. .016 20.461 151.040 1.00 26.69

ATOM 4790 CG HIS 3286 104, .002 20.468 152.154 1.00 27.68

ATOM 4791 CD2 HIS 3286 105, ,002 19.608 152.454 1.00 28.17

ATOM 4792 ND1 HIS 3286 104. .003 21.419 153.148 1.00 29.66

ATOM 4793 CEl HIS 3286 104. .960 21.141 154.016 1.00 30.81

ATOM 4794 NE2 HIS 3286 105, .581 20.045 153.617 1.00 29.40

ATOM 4795 C HIS 3286 101, ,947 18.357 151.810 1.00 26.58

ATOM 4796 O HIS 3286 101, .061 18.905 152.472 1.00 26.84

ATOM 4797 N ILE 3287 102, .384 17.128 152.055 1.00 26.39

ATOM 4798 CA ILE 3287 101, ,846 16.312 153.131 1.00 26.11

ATOM 4799 CB ILE 3287 102. .083 14.831 152.853 1.00 24.99

ATOM 4800 CG2 ILE 3287 101. ,725 13.997 154.069 1.00 22.95

ATOM 4801 CGI ILE 3287 101, ,288 14.420 151.626 1.00 23.31

ATOM 4802 CDl ILE 3287 101. .531 13.009 151.238 1.00 25.95

ATOM 4803 C ILE 3287 102. ,483 16.630 154.464 1.00 26.79

ATOM 4804 O ILE 3287 103, ,640 17.022 154.533 1.00 28.01

ATOM 4805 N GLN 3288 101. ,728 16.429 155.532 1.00 26.95

ATOM 4806 CA GLN 3288 102. ,231 16.695 156.868 1.00 27.08

ATOM 4807 CB GLN 3288 102. .097 18.183 157.182 1.00 26.69

ATOM 4808 CG GLN 3288 102. ,317 18.539 158.635 1.00 27.45

ATOM 4809 CD GLN 3288 102. ,359 20.033 158.867 1.00 27.88

ATOM 4810 OEl GLN 3288 103. ,433 20.619 159.023 1.00 29.46

ATOM 4811 NE2 GLN 3288 101. ,190 20.663 158.880 1.00 26.56

ATOM 4812 C GLN 3288 101. ,445 15.870 157.871 1.00 27.00

ATOM 4813 O GLN 3288 100. ,217 15.850 157.821 1.00 26.94

ATOM 4814 N TRP 3289 102. ,156 15.192 158.772 1.00 25.98

ATOM 4815 CA TRP 3289 101. ,527 14.360 159.784 1.00 25.52

ATOM 4816 CB TRP 3289 102. ,339 13.077 159.985 1.00 24.71 rt rt I- ro O t- o oo oo H CΛ co ro cM H ro ro cM ro vo H τ o o oo ιn ro cM T t— cn o co ro co vo cM O cn cΛ H CM CΛ ro o ro co cM in in oo cΛ T CM cn o in rs co cM CM co co ro oo in oo t— ro vo o oo r- cΛ in cM r- r- o r- r- o T o vo in ro cΛ H VO CM cn t— cn ro cD o o r- ro o T t- cn oo H ro in m vD CD CM β ■a o n tn ( H N N N O H ιn Φ ω lB ^ ^ m ^ ffl Λ 01 H n v ιn Λ o o H H N ιn ^ Φ ιn H l ( ( ιn Φ ιn N N H O H <ι^ι ι Φ ιn (!l O flo co

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CO rO OO OO CM CM m rO OO rO rO rO m

H oooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooo U

PM H H H H H H H rH rH rH rH rH rH o in oo vvoo i— t— cΛ co ιn OT CM CD τ oo τ oo ιn o σ^ VD θ H oo o σ^ τ cD CD rn τ H CD in c» o o cΛ oo ιn <Λ r- cΛ ιn τ vo r— c O H vo m CΛ o vo

CΛ O co m m ro oo cM en vD cn vD in H oo cM m vD cn in cn ro o !— oo ro co o τ ro oo <Λ co r— T CM in m o H t— VO OI CO CΛ CΛ H T ro CΛ ro o vo

CΛ O 000o0o 0o0o H in m τ o m vo en ι— τ ro cn o t— cM τ cM θ co co r- CM OO Γ- T H Γ- OO O OO I— cn τ ιn r- CM cn ι— t— H ro oo τ r r- ro cn in ro CΛ

CO CΛ Γ- eΛ r- r- c— cΛ oo H H H CM CM CM H H τ co ιn vo r— oo oo cn o t— i— r— oo oo vo in vo T T CΛ O oo t— vo m in t— oo t— t— oo oo cn cΛ cΛ in in in ro in m in in in in in m m VD VD VD VO VO VD VD VO VD VD VD VD VD D VD VD r- VO VD VD VO VO VD VD VD VD VO VD r— VO VD VO VO VO VO VO VO VO VO VD VO VO VO VO VO VO VO

HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH HHH HHH HHHHHHHH H H H H H H H H H

T OO cn eΛ CM in in o H CΛ H vθ H oo o cΛ θ τ τ τ ιn oo oo co o vo cM θo m τ t— CΛ T CM H r— ro m τ cM θ ιn co H θ co H co τ co ιn cM CM r- m

CM CO r- CO O H OO O H CΛ O rθ H OO CΛ OO O O H t- τ H τ r T H CM O O 00 CΛ CM f- r.- ro τ ιn H oo oo oo H Vo vo oo crι vo τ m ro oo t- oo τ O H O O t- t— T H rO O t- o r- t— H H O co co H T CO Vo t— in T in VD CM H O 00 CM 00 OO CM o cn oo oo o cn ro t- vD ιn cM H τ ro r- o oo (— vo cM cM H θ H H θ cn o cΛ ιn m m m co oo oo cn τ oo ιn τ oo cM CM H H m vo ιn vo co vo r- m vo ι— co o cn o CΛ H CΛ o oo oo r— vo in T in r— vo oo oo

H CM H CM H CM H CM H H H H H r-

H r rO OO CM VO O O O OO O CM t- r- H OO T CM H in r- cΛ τ cΛ o t— (Λ oo cΛ in o in o oo t- m cΛ vo m oo in CΛ T I— in o vD in r- T CM ro ro o ro oo H o ro co τ cn eM CΛ io τ co τ θ H vo τ m τ cn T Co r- cM oo r- ro cM oo ro ro T i— o τ τ ro cΛ in <Λ o oo ιn m σi CΛ r- H OO r- O O CΛ CO CM O H CM o o oo oo t— vo o oo t— co ro oo cM cn co eo T H oo t— VD rH OO CΛ VD T T T CΛ CM T eΛ vo H in τ ro vD τ ro co m o o ro o cn oo cD o ro oo in r- ro m cΛ cM O O en cM CM cn oo co H CM O CΛ 00 CΛ O oo cΛ oo cn cΛ o en oo oo cn oo oo t- co τ τ ιn ro ro τ T cloO vVDD oOoO oOoO oOoO [r—- CΛ O H o cM CM T T Oo in cM CM co ro

O O O CΛ O O CΛ CΛ CΛ O O O CΛ Cn CΛ O CΛ cn cn cΛ CΛ O CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ CΛ cΛ CΛ Cn CΛ CΛ CΛ Cn CΛ CΛ cΛ CΛ CΛ O O o o o o o o o o o o o

CΛ lΛ lΛ CΛ CΛ CΛ CΛ CΛ cΛ cΛ CΛ O O O O O O O O H H H H H H H H H CM CM CM CM CM CM CM CM CM CM ∞ CD CO CD CO OO CO σ^ Cn Cn Cn Cn cΛ Cn cn CΛ O O

∞ oo oo co co cD co co co co co cΛ cΛ cΛ cn cn cΛ cΛ cΛ cΛ cΛ cn cn en cn cn cn cn cn cn cn cΛ cn cΛ CΛ cΛ cΛ cΛ o o o o o o o o o o o o o o o o H H

CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rO OO rO rO O^ ro ro ro oo oo oo oo oo oo oo oo ro oo co ro oo oo m oo oo m ro eo ro oo ro n ro oo oo eo oo oo oo m oo oo oo oo eo m ro ro m n ro r^ l-H CH CH C CU M C αj e CM D D D D D D D D C CO C C CO CO CO CO C C C C C W CO C CO t C Hl i-l J oa cfi « o- o-; oH θ- cc; o. ofi θM ω ω ω ι-, j ω ω ω >^

H CM CM H H CM H CM H CM υυoυozυυoυo f CQ CD Q Q fit CQ CD Q si fit CQ O D Q C-H u fit CQ Rt pa o Q ω ω A o υ υ o o o o o oo υ υ z o o υ υ o o z υ z o o z o o υ υ o o z υ υ o υ o z υ o z υ m m o ri N n ^ ιn ^β ^ o o H ( n 9 ln « r- oo (^ι O H N lO fl ιn ^ m ol O H N π ^ ln Φ ^ <D <n o H ^^ ( ^•^ ln ιo ^ (D lI\ O H (^l H H H CM CM CM CN M M CM CM C M o o o oo r oo m ro 'T T in in in in in i in in in in vD VD vD VD VD vo vD VD o v^

∞ OO OD OO CD ∞ ∞ OO ∞ OO OO ∞ ∞ ∞ ∞ ∞ ∞ OO ∞ ∞ ∞ ∞ ∞

*^* Kf K Kf Kf Kf ^3* ^3* Kf Kf Kf ^3* Kf ^* Kf Kf Kf Kf Kf Tf Kf Kf Kf Kf Kf Kf Kf Kf Kf ^3* ^* ^* f **3* Kf Kf Kf ^* ^* ^3* ^3* ^* Kf Kf Kf Kf Kf Kf ^* f Kf Kf Tf Kf f ^3* se vo

ΣoΣoΣoΣΣΣ ΣΣ

© oΣ oooΣoooΣoΣoΣoΣoΣooΣΣoΣooΣΣoΣoΣoΣoΣoΣoΣoΣoΣoΣoΣooΣΣooΣoΣΣoΣooΣΣooΣoΣoΣoΣoΣΣoΣoΣooΣoΣΣoΣoΣooΣΣoΣooΣoΣ o A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A

rt rt t- ro tn en m oo in vo oo H co vo in in m t— o vo vo cn co T CM O CΛ VO VO H OO O OO H CΛ VD CM H OO o ro rΛ H oo oo H T co cM VD in H T in r- vo in ro in r- cs o cM cn cM ro ιn oo m r- cΛ oo oo co τ cn r- ro co ιn vo ∞ H 0θ '3^ι ro (Λ r— in co cM T in τ θ H ro cM oo cM CM θ cn oo cM CM CM rH in t- cM cn τ ιn

© © 8 r- t- ιn m co o vD VD f- cΛ CΛ cn vo r- iιnn iιnn iιnn cmn tr-- CoDo CcMM tr^- tt—— r ooo ocoo oooo vvoo tt—— cCΛn oO θO HH θO CCMM rΓoO cCMM oOoO oOoO oo ro ro τ τ vD ro τ τ ιn ιn ιn vD τ ιn τ ιn τ CΛ '"

CM CM CM CM CM rO CM CM CM CM CM CM CM CM CCMM CCMM CCMM CCMM CCMM CCMM rroO cCMM CCMM CCMM CCMM CCMM CCMM CCMM rrMM rroO rroO nrO rroO rOoO nrO rroO rOoO oOoO ro ro ro ro oo oo oo ro n ro oo oo ro ro ro n

H oooooooooooooooooooooooooooooooooooooooooooooooooooooooo υ oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

PM H H H H H

O r- CM CM t- VO VO f- T CM CM H T rO CO T *-3* CM T CO H O_ t.- M CΛ CM T CM CM CΛ m O in H VO CΛ in Cn T CΛ OO O rH T CΛ H H OO r- O m CM OO T T cn cM O T ro vD r- o o vo cM r- r- r- H in cM cri m r- o vo oo cn H CM in H o o m n oi Φ N ffl O iΛ io n ci io in in oo to o n oMri M in N Mn CM co T OO H cn ro in r- o o cM CM ro H co ro oo vo H σi oo r- o vo o co oo oo r- oo ro o ιn oθ (Λ vθ ιn ro cΛ r- CM r- rΛ ιn cM ro vo cΛ oo oo τ cΛ θ H ι H ιη N 'J ^ (n ro t^ lrι ln * l N H lΛ m oo α) oo «) o (o (D ^ ^ o) ^o ιn ιn ^ n N o^ (η N H H H H O o o ol H H ( ^ ln ι(1 Φ ιn ^ 'l^ι v •J Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ in in in in in in in in in in in in in in in in in in in in in in in in ji in in in v in in in in in m in in in in in m

H H H i-H H H H H H H H H H H H H H H H H H H rH H rH rH H H H H H H H H H H H H H H H H H H H rH iH H H rH H rH H H H H ιn H oo o CΛ CΛ O O ιι^• ln•»

00 t— T t— T r- cn cxs t— H T t— cΛ o co c in in i— in cM CM CM VO T H t— H in π r- in oM co t— T Λ iO T O in in H co T t— CM ro <Λ oo oo vo ιn τ oo H

00 CM VD I— H ι inn oooo oo ιinn c ooo τT c CoO oO HH rI—- tt—— HH rOoO rrΛΛ iinn oO TT VVDD CCMM OO CCMM cCΛn rr—— oOoO rroO HH rroO oOoO oO oOoO iinn cCMM tt—— tt—— τT oO cCoO oO ιVoO oOoO cCMM CCΛΛ tt-- oO cCΛΛ CCDD rro cCΛΛ rr-- HH VO CΛ 00 T CO t— in oo in in τι H CM r- rO OO O CM H CO O OO cn VO Λ rO CM rO in CD CM H CM CM CM rO CO CO VD CΛ O CM in T O CM CO VO O O O OO CM in VO τ ro cM τ m τ ιn τ oo cM τ co t- in VO in VD VO I— t— CO T VD VO CD VD VD t— OO VO r- VO OO OO CΛ O H H CM OO in VD T T in T T T VD VD t— OO T CM H

OOOOOOOOOOOOOOO O O O O O O O O O O O O O O O O O O O O

O O O O O O H H H H H H i cM CM CM CM CM CM CM CM CM ro ro ro ro oo ro r T T T T T in in in in cD VD VD Vo vo vo vo r- r- t— t— r- t- r- r- oo oo

HHHHHH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH oo ro to ro oo oo ro oo oo oo oo oo oo ro oo ro ro ro ro ro ro oo ro ro co co ro oo oo ro ro ro ro ro oo o^ ro ro ro oo oo ro oo ro oo m oo ro ro ro ro ro ro ro oo oo ro ro oo ro ro eo ro m oo oo ro oo oo ro oo ro ro oo ro ro oo c ^~o^~ ro ^" ro ^" r -o^~ ω ω rj rj r^j ω D D D D D D D D C C CO C CO CO W C C Oή C-. el OCl pH pH l- ^ iC ii iO^H ^ X ^ J J J J J J l Z Z Z Z Z Z Z Z o; -!

H^ H3 HH HH HH H cd ω ω ω tι^] ω ω ω >H >H H H >H >H >H H >H ffi x ac ar- a: -C X rl ri r r ri ri rl rl rl A A A A A A ft w ui cn cn n cri cn cn x x

H H H H rH H r^ H^ H^ IH H^ H^ H^ Hl HH HH HH HH HP H-1 h-l HH IH EH EH H H H EH H rt! rt! rt; ft fit O O O O > > > > > > > fit < κt fit fit fit fit rt; EH EH

CM H H H CM rl CM H CM H CM

PQ CD CD Q fit CQ CD Q Q fit to o Q ω i υυυυoozooooooo fit CD C ft C o o υ o υ z o o z oυCQooDυoz fυt CυQυozυ ftυoziooQ OoCoDυo z fiυt CυQ CυD Qo Qzooz fiυt ro T in vo t— ∞ cΛ θ H cM ro τ m vo t— co cn o H cM ro T in vo r— oo cΛ O H CM ro T in vD r- oo cn o H CM rO T in vo r- oo cΛ θ H CM co τ m vo t— oo ^ ^ ^ ^ ^ ^ o!ι !o α⁾ αl α⁾ α⁾ α⁾ lD oo oo o^ ιll Λ Ol ⁽Il ffi ffl ⁽Jι ιΛ <^l O O O O O o o o o o H ri H H H H H H H H (^ι ^l N !^ι (^l I l ( l N ι

∞ CO ∞ CD CD CO CO CO CO CD CO CO C» CD CO CO CO OO OO OO OO CX) CD CO CO CD CD CΛ CΛ CΛ CΛ cn Cn CΛ CΛ CΛ cn cΛ C^ T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T

00 rH rH Σ ΣΣ O oΣooΣooΣoΣΣΣΣoΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ o EH H EH H EH EHoHoHoEHoEH EHoEHoEHoEHoHoEHoEHoEHoEHoHoEHoEHoEHoEHoEH EoHoEH EoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoHoEHoEHoEHoHoEHoEHoH

A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A it

ro rs VO oo _{T C}M ro ro H O CD Co ro vD ro o m r- in oo oo cM CΛ in in oo oo H o vo ooo oo T oo oo co co co cn in o r- t- VO CM VO H 00 H 00 O CO t— CM cn

VO CM CO τ r in θ VO T VD CM CΛ ιn m H OO CM r- <Λ VD <Λ O OO O T OO t— CΛ O OO OO O OO CO OO H H vo CM CM en T T CM Λ in CM T CO t-

© ■SI

"S τ m m τ ιn ro ro ro ιn τ H cΛ o o oo r— t— oo H CM ro vo t— ro cM VO t— t— t— r— oo O O OO I— t— VD VD VO in τ VD t— CO OO CΛ H T t— CΛ r— oo oo vo fi ro ro ro oo oo oo ro ro oo oo oo cM ro ro cM CM CM CM Oo oo ro ro ro T T Oo ro oo oo oo oo τ τ ro ro oo eo oo oo ro ro ro ro ro ro rθ τ τ τ τ τ ro ro ro

H O OOO O OOOOOO OOOOO OOOOO O O O O O O OOOO OO O OO OOO O OOOOOOOOO OOOOO OO υ O OO_O O OOOOOO OOOOO OOO OO OOO OO OO O OO OO O OO OO O O OOOOOOOOOOOOOOOO

PM

(Λ i in c 'r i i co H o co erj H H t— H vo co cn cM cΛ ιn τ ro oo o cM r- cΛ o cΛ co o r— vo co vo oo r— vo o vo H H vo in H o CO 00 I— CM T T in cM O r- r- cn t— o c» cn oo ιn vo vo vo vo ro o ro o cΛ ro ro o τ τ τ vo <Λ τ CΛ t- CM r- o cΛ ro vo cM ι-i H Vθ τ H.. o„o r.o. o CM o r- ro cn H o vo ro ro ιn cM oo r- oo ιn vo o τ ιn τ ιn τ H H CM ιH in α5 CM ro cM H H H in vo vo t— o cΛ oo co cn o r- oo o vo cΛ oo H imn voo TT OΛ <Λ vo T H VD LO H CM CΛ in vD in cM CM H O cn o cn o en cn oo oo cn r— CΛ CΛ CΛ CΛ CΛ CO OO r— t— o o H ro ro ro τ ιn τ ro τ oo ro cM ro m ιn oo τ cM CM rH θ cΛ oo oo τ τ τ ιn ιn ιn ιn m ιn m τ ιn τ in in Kf Kf Tf *^* ^* T* Tf Tf Tf τ m m m m m m m m m m m m m m m m m m ιn ιn m ιn m τ τ τ m ιn m

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

00 O CO O f- O CO CM rH T oo in cn T CO T Vo cΛ t— r— τ ι— Λ Ch cvi m H oo cΛ ro cΛ CΛ oo cΛ r- H o vo cΛ vo oo oo m m o t— co cn oo CO CΛ CM 00 f- O CΛ CΛ 00 00 H oo ιn o oo cM θ CM vo τ vo oo cΛ ιn ro τ vo ro r- τ t— vo cM θ ιn τ t— cΛ T H in vo rH r- O H in

H t— CO O t- CM H T O O m vo r- in o vo vo o o vo cM oo ro H in o H vo cM oo co r- in cn cn vo c t— o o o oo o T cn ro vD in oo H O T OO CM

Ti ro co T T CO ro cM H co cM H CM CM CM T T Ti o o o oo oo oo oo cΛ O oo r— oo oo oo cΛ en cn cΛ oo oo cΛ O CM Co rO T O O oo oo r— co r— r— oo r— vo r— cn t- r- m o cΛ CΛ VD oo cΛ r- ro o ro o oo cM r- ιn vo o H θ CM in τ vo τ H in t- O T O H H rΛ OO CΛ CM CO CM H ιn τ O CΛ CM T CΛ CM in H ro co r- ro cΛ oo cM H oo cΛ r- in o o oo in cM H O T cΛ o oo cΛ VO H oo t— oo τ oo ro r- τ ro vD H VD oo oo <Λ Vθ o r- CM τ r- oo oo r- r- in co co T t- t- vo ro T oo r- cM vo in r- cΛ ro o in cM in o O CM in CM T CM in T VD O VD T OO CM OO rO rH O H co m cM oo vo in in oo cM ro cn o cn H O H H CM cn cn co t- vo co m vo i— vD co oo o o cM ro ro oo t- oo oo cΛ O rH r- vo vo in in vo vo ιn τ ro ro cM CM rH H rM θ CM rH ro

O rH O H HH HH /O-ι <O-ι ιO-l rO-^vO-ι rO-ι o o O O O O H H H H H O O O O O H H o o o o o o o o o o o o o o o o o o o o

H H H H H H H H HH H HH HH H H H H H

OO OJ CO CO OO Cn cΛ α^ CΛ Cn CΛ CΛ O O O O O O O O H H H H H H H H H CM CM CM CM CM CM CM CM CM rO OO OO rO OO rO OO rO T T 'S' T T T T T 'T in H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM c oo oo oo n n n ro oo ro n oo oo ro ro oo oo oo n ro oo ro ro ro oo n ro n ro ro n oo oo oo ro oo ro ro oo oo oo ro ro ro ro n ro m m ro n ro ro ro ro oo ro ro ro ro oo oo oo oo m ro ro ro ro oo n ro m oo oo n ro co c oo m ro m

Cu tlS C-i Cή P≤ Pd Oi PS pS lXi pS Pή CU CH CH l-j CU CM CM CU CO CO CO CO CO CO CO CO CO D D D asssaissϊaKinntnwBMnn^^^^^^^^^iHhHiHiHhHJhHαjωωωwωuωuj

EH EH EH H H EH EH H EH EH EH EH fit Ftt κ rt; fit fi rt; HH HH HH HH HH HH HH Hq HH θ O CD CD tD Σ Σ Σ Σ O C CD O O O CD O CD >

H CM H CM H CM H CM H CM CQ O CD fit CQ O O fit CQ CD D α ift O Q ω H rt! PQ CD Q ω ω υ o o υ o υ υ o υ υ o z υ υ υ o o υ o zυυQ Ooυosziυoz fiυt CυQ CυD QυoWor-Hυo fit CQ O Q υ υ υ co υ υ o zυυυυooυo

(Jl O H ι n •» ln ^ ^ os Λ O H ι n <^ ιn a ^ co ιJ> O H (ι ιΛ fl ιn « ^ oo ιΛ O H (^l tη v ιΛ ^ os Λ O H N ι fl ln r- oo βι O H (^ι o^ ^■» cM n ro ro ro ro ro ro ro oo ro τ τ τ τ τ τ τ τ τ τ ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn vD vD VD vo vo vD VD VD VD VD c- r- r- r- t— t— t- t— r- r- oo oo oo oo oo

CΛ CΛ Λ CΛ CΛ CΛ σϊ eΛ CΛ CΛ CΛ CΛ CΛ CΛ cΛ CΛ CΛ CΛ CΛ CΛ Cn cn cn cn cn cΛ CΛ cn cΛ CΛ cΛ CΛ CΛ

^* ^* ^* ^3* ^3* Kf T* *^* Kf Kf ^^ Kf Kf Kf Kf ^* Kf Kf Kf Kf Kf Kf ^3* Kf Kf J' ^* Kf Kf Kf ^3* ^* Kf Kf Tf T* ^* Kf Tf Tf Kf Kf ^ ^ Kf Kf *^* Kf Kf Kf Tf Kf Tf Kf Kf Kf

00 rH se rH rH Σ © oΣoΣoΣoΣoΣoΣoΣooΣ ΣoΣoΣooΣoΣoΣΣoΣooΣoΣoΣΣoΣoΣoΣooΣoΣ ΣoΣoΣoΣoΣoΣoΣoΣoΣoΣoΣoΣoΣoΣoΣoΣoΣoΣoΣoΣoΣooΣoΣoΣoΣoooΣ ΣoΣo o A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A

ro O I— O O t— t— t- T H oo T CM H r- in cM oo H in vo r- T CM CO o cM CM Vo cn co cM CM rO T CM Vo ro CΛ in CD CM vo r- t— VD CM Cn H CM VO H H Cn cM js CΛ H CO T VO CΛ H VD co ro oo o m cM vo ro oo m in in m cM rH o m ro H T oo cΛ T T CM in o H CM T r- T O CM CO H CΛ in m CΛ H OO VD CΛ

VO t— 00 [- VD CD VO ιn T CM CM CM VD in r- OO OO OO CΛ CΛ O O CΛ O Λ CΛ r- T rO H O CM rH CM H ro cM τ vo cn cM τ CM m τ m ιn ιn m ιn ιn ιn vo co ιn cM rroo oooo rroo rroo ro ro ro ro ro ro ro ro oo ro ro ro ro ro oo co T T OO T OO OO OO OO ΓO ΓO T T T T τ τ τ τ τ τ m ιn ιn τ τ τ τ τ τ τ τ τ τ τ τ τ

H O OOO OO O O O OO OOO OO O OOOOO OOO OOO O OO OOO O O OO O OO OO O O O O O O O O O O O O O O OOO OO O O O OO OOO OO O OO OOOOOO OOO O O O OOO OO O O O OO O O O O O O O OO O O OO O O U

PM H H HH H H rH H H H rH H H H rH H H

CM rH CΛ CΛ OO VD T CD H O CΛ T CD CO in r- CΛ r— m t— O CM O Cn O OO CΛ OO CΛ r- CΛ rH CΛ in oo CO r- H OO CM r- CO O CΛ CM in CM r- H 00 CM VD T CM r- oo in oo oo T CM ro cM o cM T H CM ro in H CΛ oo cΛ CM in cM oo in o cM o in oo cM co en O in O T OO OO VD H OO VO VO T O^ VO H CM iH VO CM CΛ CM VO CΛ o r- in oo ro oo T t— τ oo r- m vo cn o cn τ H CΛ (x> ιn o m r- cM VD H in cΛ o cM vD oo o co in cM VO oo vo vo T rO H O VD o in ro H CO VO H t— T vo in in vo t— t— oo cn o H H eM θ θ H H H θ co cn co co ro ro τ ιn vo ιn ιn vD vD vD vo t- r- oo cn cΛ θ H CM oo cM H CM rH H H <Λ H oo o oo ιn ιn ιn ln ln ln l ιn ιn ιn ιn Φ Φ ι ln l ^n Φ Φ Φ Φ Φ r- r- ^ ^ r-• r- ^ ^ ι-- ^ Φ ι ^ ^-• ^ ^ r" [--

H H HH H H HHH HH HHH H H HH H H H H H H H H H HH H H H HH H HH H HH H HHH HH HH HH H rH H H HH cn T in oo r- OO t- T in θ rθ O <Λ O O OO CO H O H CM CΛ rθ rθ O CΛ CO OO OO VO O H CM CΛ OO CM CΛ H H CΛ CM r- H CM in c- o oo cn vo ro vD m o m H

VO D O t- O—O C.M. T. H OO VO r- VO CM in O OO H O VD CΛ CΛ VD CΛ CM O lD O σ in VD T O r- r- r- rO H OO CM OO τ r— ιn ιn cΛ τ o o ιn oo ro cM r- CΛ in ro cn o CΛ o OoO CCMM <CΛΛ Ti CM r— OO CM CM T H CΛ Ti crj H H VvDo OroO CcMM rroo rrOo ri—— c <nΛ ctMM iinn vvoo vvoo r- r- oo t- cn vo vD oo o ι- o T OO O OO CΛ Λ OO O T OO CΛ CΛ O CΛ OO ιo τ ιn oo vo t— vD r- oo oo cn cΛ VD m co τ τ co τ cM CM oo ιn vo τ τ m VO CO t— rO CM rO CM CM CM OO H H O O O H CM CM H CM CM ΓO H CM H OO T T CO

I

O

H H t— CM CΛ T t— VO H OO in H OO CM Cn cΛ VO VO CD CM OO OO t— CM O T r- m cM in τ vo oo H oo cM H cn co oo τ m tn co oo cΛ CΛ CM VD oo r- m τ o vo in OO OO VD T OO OO t— CM T VD CΛ r- OO H OO T T f— CΛ in CΛ OO in VD T cM cn vo m o H in co cn ιn,τ t— cΛ H oo H CM CM CM Vo r- o r- cn o vD o oo oo

CM t- CM ro cΛ H H VO vo cn eΛ VD cn o cM in cΛ eΛ m H ro H CD ro oo oo OO rO VO T OO r— T CΛ H H O I— O CΛ in H CΛ T VO VD CM T CD T CΛ OO VD VO CM co ro m ro oo in oo oo cM CM ro H ro ro in m co vo r- vo vo c— m vo τ oo cM H oo m τ vθ [— co t— r- r- vo oo t— r- oo m vo T rO CM CM H CO rO CM CM OO rO

O O O O O O O O O O O O O O O O O O O O O O OO OOOO OO O O O O OO OO O O O O O O O O O O O O O O O O O O H H H H H H H H H H H H H H H H H

i _n. i_n. i_n. i_n. i_n. i_n. v _o v _D v _o v _o VD VD VD VO t— t— r- r- r- t^ t— r- l- r- OO OO CO OO OO CO CO CO CΛ Cn cΛ CΛ CΛ O O O O O O O O H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rO OO OO n o^ oo ro ro oo ro ro ro ro oo oo oo ro oo oo oo oo oo oo oo oo oo oo ro ro oo oo n ro oo oo oo oo oo oo oo n oo oo oo oo oo ro ro ro ro oo m oo oo oo oo oo oo n ro ro ro oo oo oo oo oo n oo oo oo ro oo ro ro ro n ro oo oo oo ro ro ro oo n oo oo oo n oo ro fit fi fi rtβj fi ^Dω ^Dω ^Dcd ^Dω ^Dω ^Dw ^Dω ^σω ^OTH ^WhH ^WH ^WH ^WhH ^WH ^OTH ^WH ^WH ^WH ^Dω ^Dtd 'c--^Di Dcq ω ω ω ω pi CM

> > > > > > _>j j _hq _hH j iH j j B a a a a a a a a iH j hH Hi Hi Hi Hi Hi 3 3 (< ^(j; «; a; > > > > > c w ra w

H CM H CM CM H H CM H CM H CM H CM fit CQ CD CD fit CQ CD ^Q Q fi cQ CD Q Q ω ω ft C O O O O Z υooυoυoz υυυυ zυzυoz oi υQo Oυ Q Qυoozυ f υ CQυo fit CQ CD Q Q fit CQ O CD fit CQ CD υυυozooz O O O O O z o υ o CΛ O H CM OO T in VO I— OO CΛ O H CM OO T in VO t- CO Cn O H CM CM CM CM CM CM CM CM CM CM ro ro ro ro ro r ro oo ro rO T O^■ι"n' OO OO OO OO OO OO OO O OO OO OO O OO OO OO O OO OO OO OO OO m m m in in in m in m in m in in in in m in m in in in

oΣoΣΣΣ EH EHoEHoEH ! ! ; t t rt rt f rt f fi fi fi rt fi fi fi fi rt fi

θ m o t- O CM CΛ CΛ OO T t— O in T m CΛ Cn rrθ ιr—- iVOn T T T OO oo cM cn o CM T in VO H VD CΛ H H θ θ cn co oo oo vo oo oo t— OO OO CΛ CM T VO ΓO T ro oo oo oo cM CM CM CM CM CM oooooooooooooooooooo oooooooooooooooooooo vo oo m o τ θ oo cΛ r- oo vo oo cM CM r- ιn <Λ oo oo H in vo o τ cM in vD τ ro ro oo τ m t— oo CM in oo cM VD τ ro vo ιn τ oo H θ ro ιn o oo cM cn o ιn vD θ vo o co H H CΛ H oo cn vo τ τ τ cM τ τ m H in τ m o oo τ vo ro cM co t— H Vθ m τ H ro m τ o cM θ τ en r- ιn r- oo cΛ t— oo cM r- o τ t- CM θθ τ t- H vo cΛ VD ro o oo cM cn cM co H τ ιn ιn vo ro cΛ in rH τ co oo H r- ιn vθ '3^| vo cΛ τ O m O OO '-D CM CM OO OO CO Cn rO VO CM OO O CM CM T rO T

T V0 V0 0000 CΛ r- O 00 CΛ VD in V0 m V0 r- t- 00 V0 τ r000 CM rH H H CM rH O CM CM 00 H cM rH O CΛ oo oo r- t- m m vo T vo vo in T T in vD t— in vo r- r- t- r- i— r- r- oo r- r- r- r- r- r- t- r- r- t- t— i- r- r- t- i— r- r- r- r- r- t- i- r- r- t— r— C— VD VO VO VO VO VD VO VO VO VD VO VD VD VD VD VO CO VO VD H H H H H H H H H H H H H H H H H H H H H H eΛ CM co vo cM H r- vo cΛ r- r- ro H H O m o r- O CM O O in r- cΛ H C CM ro cn co t— VO OO in T H T O VD o ro rM in t- H ro cΛ T i— IΠ T H CΛ H rO H CΛ CM H H CΛ O CΛ O O Cn r- OO r- <Λ co CΛ ro r- H CΛ CM T CM OO H T CΛ CM Γ— O τ ro cΛ CΛ ro r— r— r— H T T imn vcoti ccMM roπo oooo ccM rt—- o cM oo o o T in t— ro vD oo cM co co cn o vo cM r- ro oo r- H vo r- ro ro cn t— o o en Λ o co co H T Oo oo vo vo m oo oo oo o ro cM t- in ro T oo cΛ H ιo ^ 01 n m H r- » ιn ^ ιn ιn ( ( N c^ι H ri ^ co m m oo ω m co m co oo a) ln ^ ω ^ ^ ω α ffi (^ w co H H C^l N ) 'J (O H N H H O o m oo o cn

VD H [— CΛ m τ C0 VD T ⁽Λ o m 0000 VO O VD ιn VD VD H H T V0 T CΛ T H in CM 00 ro ιn τ vo σι cΛ H τ en τ oo oo m <Λ o τ ro H in H ro co o ιn CM τ ro ι- t- oo H CΛ r- ιn cM CM cn ιn oo m o vD cn oo o τ co cM CM τ o oθ τ m r- ro CΛ T T H OO H OO OO O O CM in t— T OO OO tn CΛ CΛ m CΛ I— CM H VO (N t- cD oo cΛ vo t— O T t— cn ro ro m r- cM t— cM oo cn τ vo o oo vθ H r- vo ro cn m oo m cn vo o t— t— o o oo H Cn ro H vo OO i-H T H in cM

H O O cn oo co oo co co t- r- cn oo o o cM CM T T T o en H O rH ro ro oo cΛ co co i— vo vo vD in in T T T T CM CM rH o o in in in vo r— oo r— oo cn o o o o en cn cn cn cΛ cΛ CΛ cΛ cn cΛ o o o o o o o o cn O O O O O O Cn cΛ Cn CΛ CΛ CΛ cΛ cΛ eΛ CΛ CΛ CΛ CΛ CΛ CΛ Cn CΛ Cn CΛ Cn cΛ CΛ Cn cn cΛ CΛ CΛ O

CM CM oo oo ro oo oo oo ro ro oo ro oo τ τ τ τ τ τ τ τ τ m ιn ιn m ιn ιn m m vD vD vo vD VD [— t— t— r- oo co oo oo oo oo co oo co cn cn cn en cΛ cn cΛ cΛ ro ro ro oo oo ro ro oo oo oo ro ro ro ro ro ro ro ro oo oo n ro ro oo ro co ro ro ro ro ro ro ro ro M ro oo oo oo oo ro ro oo oo ro oo oo ro ro ro oo oo ro ro ro ro ro ro oo ro n ro oo ro ro n ro oo n ro ro ro oo oo oo m oo oo ro oo ro co ro ro ro ro oo oo oo ro oo oo n oo oo n oo eo oo oo co oo ro oo ro ro ro ro oo ro ro ro n oo ro ro ro m m

^ ⁽( U mil lil lil U U U mil lil Q D D D D D D D D Ili Oi l- l- l- l- l- l- ft rt! >< >H >H < D D D D D D D D D CH θH CH CH Cc; c>H C£; i-H w a x x x x ai X X X x x ai r ri r rl r ti ri tn u' Ui m m cn ui ui il Hl J HU iJ J tq ^ j i Hl Hl J J ^ ^ ^ ^ ^ X ^ vi c c M C a^ cu cy u c aι CM aι a^j θ θ θ θ θ θ θ θ θ fit fit rt: rt! rt! fi fit O CD CD CD CD O CD O CD CD O H EH H EH EH EH EH &H

H CM rH CM H CM H CM H CM H H CM CM υoz fiotυCQ CυDυQυQ PυQ HυSυIυoz fiot CυQ OυQoUooUυo fit CQ Q Q f cQ fit fi ca tD a ω ω < CQ CD Q W Q W o o o o o υ o z υ υ υ o z υ υ o z υ o υ υ o o υ o z υ υ υ υ υ υ o

H CM co τ ιn vo r- ra cn o H CM C τ ιn vD r- cx) cn o H CM ro τ ιn co t- oo cn o H CM ro τ ιn vo r- oo cΛ θ H CM co τ ιn vo t— oo <Λ θ H CM ro τ m vo T T T T T T T T T in in m in in in in in in m vo vD vo vo vo vD VD vo vo vo i— r- r- r— ι— r- r- i— r- t— OO OO OO OO OO OO OO OO OO CO CΛ CΛ CΛ CΛ CΛ CΛ CΛ o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o in in in in in uo tn in in in in in in in in in in in in tn in in in in in in in in in

00 rH rH Σ oΣoΣooΣΣoΣoΣoΣ ΣΣΣΣΣΣΣΣΣΣΣΣΣΣ o o EHoΣΣ EH EH H EH EH H H EHoEHoΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ EHoEHoHoEHoHoHoEHoEHoHoHoEHoEHoHoHoEHoEHoEHoEHoEHoEHoHoHoEHoEHoEHoEHoEHoHoEHoHoEHoEHoEHoEHoEHoEHoHoEHoEHoHoEHoEHoEHoEHoEHoH o A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A it

H m τ (— o in in t— ro r- oo ro vo τ o oo o ro en oo vo H O oo rH H CM r- vo cn vD o oo o T H r- r- r- O T T VD vo vo in H co H oo r- T in CM O CM VO H f- CΛ CM CΛ VO CM OO OO O VD Γ- oo en H H H cri H α3 VD CD in τ ιn ιn τ τ τ ιn ιn ιn τ ιn vD ιn r- oo cΛ τ oo o oo r- ιn τ ιn τ cΛ CΛ OO n rO CM ro CM CM CM CM CM CM CM CM CM C OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO rH rH rH rH rH rH rH rH rH rH rH rH

T T VO VO VO 00 H I— vo cΛ r- co r- ro co m ro cΛ τ oo o cΛ oo cn cΛ CM in H CΛ cM r- o oo cM Λ H oo r- T in vD H oo m cM i— T oo co m oo o en vo ro o ro CM f- T in H oo in cM CM oo T vo vo cM VO T OO H vo o H vo co vo σi co oo ro in r- r- o eo oo co o vo H H ro oo ιn co τ τ o o o t- 00 T T t— in vo H r— T CM m in cM rH ro cn r- o vD oo cM cn oo oo oo T O O O Λ vo oo cn cΛ T t- vo r- vo m cM θ r- cΛ ιn τ ^< oo cM θ rH H o oo vo m oo H θ CM

^ co ιo N ι^l H H N O o o co ^ ^ ιfi Φ ιn ^ ιfi ^ Φ ω αι ln ιn n N H H H H O Λ Λ Q3 ^ ^0 Φ Φ ^ ^ co Φ Φ ιn ^ Φ Φ Φ ιn ^ ιι ιO M ^ r• vo vo vD VD Vo vD cD vo vo vo vo ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn τ τ τ τ τ τ τ τ τ τ τ τ τ τ τ τ τ τ τ τ τ τ τ τ

H rH H rH H rH H rH H rH H rH H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H eΛ ro co vo vo o t- co in o H in τ oo o cn co t— cM Vo r- τ m ιn oo H τ oo cM m cΛ o vD oo oo ro o i-i ro oo vo O T CΛ OO T T CD CM H Φ o co m m

CM T OO H VO T T O H T cΛ CΛ ro oo H o ro oo cM in H CΛ in H oo oo cD t- in oo H T in r- in m o o r- H CM O O OO r- t- CM CO OO O in o T i— T

H I— H t— o vo o o vo r- ro T r- r- ro in r- cn H in r- T H O T Vo ro r- oo vo oo oo H cn m oo cΛ m cM o m t- H t- o oo ιn ro ιn r- oo H oo ro o cΛ oo cM H ro oo ιn m ιn rθ τ co oo τ τ cM CM in vD oo cΛ CΛ θ [— r- r— t— ιo oo oo cn θ H H H cM H H CM H τ τ τ vo vo vo vo t— ιn ιn τ τ ιn τ ιn vo

H H H H H H H H H H H H H H H H H H H H CM H H H H H H H H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM

CM vo i— τ o cn ιn ro τ H oo ιn cM oo ro cM <Λ τ θ H t- VO in θ OO T in θ CO O O OO VO rθ O VO T H H OO O OO CM O CO T H O CM CM I— H τ r rθ CM ro H CM oo t— CΛ r- oo t— r- ro o ι-H oo cM CM in τ r— T o cΛ cM rH CΛ o CM CΛ CM m ro ιn H τ co cM vo H CM σo vθ H CM CΛ ro cM CM θ τ oo cn t— co r- co in CM CO r- T OO OO OO I— OO O T CM CO in O CΛ in H T ιn <Λ cM ro cΛ cn oo o H m τ vo co ιn H i— en oo H τ τ H cn ι— vo cM θo τ oo oo τ cΛ ιn ιn m o m ^ Φ m vf ^■J oo ^ m ^ ^ ^ m ιJl t ^ ^ ^ αl ^ ω o ^ co co m Φ co r^■ o ω oo (D Φ Φ m ^•• f ι ^ ( f') c^ι cn o cΛ n iΛ cΛ CΛ CΛ cn cΛ cΛ en cn cn cn cΛ CΛ cn cΛ σ^ cΛ CΛ cn cΛ cΛ cΛ cΛ eΛ cn cn cΛ cn cn cn cΛ cn cn cΛ cΛ CΛ CΛ cn cΛ c^

<Λ cΛ CΛ CΛ o o o o o o θ H H H H H H CM CM CM CM CM CM CM CM ro ro ro oo oo τ τ τ τ ιn ιn m ιn ιn m ιn ιn vD co vD co co vo r- r- r- r— r- r— t— t—

OO rO OO OO T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T ro oo ro ro n ro ro ro oo oo oo m oo oo oo oo ro oo oo oo oo oo ro ro co ro oo n oo ro ro ro m ro m n ro ro ro ro co ro ro ro ro ro ro oo oo oo n oo oo ro n ro oo n ro ro ro ro ro oo oo oo n oo oo ro oo ro oo n oo oo ro oo ro o^ cύ ai oi eύ cii X cύ Pi Pi cii cύ cn cn cn cn cn cn D D D D D D D D fit fit fit fit fit π H H >H z z z z z z z pH θH θH pH (-H PH ω w -i ω ω ω ω c-i

X X X X X X X X X X X X X X X X X w ω ω ω ω ia c-i ω HH rJ j.. j i^j j j Hi Hi ww n oi n w tfi n i- mii u w w iH Hi tH Hi Hl Hi iJ Hi

EH EH EH EH H EH EH H EH EH H O O O O O O HH - fH ^ u μi J iH fC rtK! fit fit CD O CD O ft fit rtl fit fit fit fit fit CO CΛ CO CO CO CO H H H H H HH HH H

H CM H CM H CM CM H H I X fit CQ CD CD A ω CD A cQ CD a a fit CQ A f CQ CD Q Q fit CQ CD f CQ CD CD Q

O O O O O O O O o o o υ co z o υ o υ υ o o υ υυo z υ υo z υooo z o o z υo o oo υ υ υ υ υ o o

^ co <Λ O ri N n ^r ιrl ^ ^ m ιΛ O H N ιo « ιn a flo ol O H N ιo ^ ι⁾ ω ⁽!l O H ^ι ^ v ln ω ^ ⁾ lJ^ O H N ι^») ^ ln ^o ^ co ιll O H N

CΛ CΛ ^CΛ O O O O O O O O O O H H H H H H H H H H CM CM CN CM CM CM CM CM CM CM OO rO OO rO rO rO OO rO rO rO T T T T T T T T T T in in -O O O O H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H mm mm m mm inmmmtnmmmmmmmmmmminmmm mm mmmmmmmmm m mmmmmmm

00 rH vo Σ Σ ΣΣΣΣΣΣ∑ΣΣΣΣΣΣΣ∑ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ β oΣ

EHoΣ HoEHoΣ EHoΣ EHoΣΣΣΣ HoEHoHoEHoHoΣΣ ΣΣ HoHoΣ EH EoHoHoΣ EHoH EoH EoHoEHoHoEHoH EoHoHoEHoEHoEHoHoEHoEHoEHoHoEHoEHoEHoEHoHoHoEHoHoEHoEHoEHoEHoEHoHoHoEHoHoHoHoHoEHoEHoEH o A A A A A A A A A A^{^} A A A A A A A A A A A A A A A A A A A A A A A A A A ft A A A A A A A A A A A A A A A A A A A it

∞ O O CM T T T O T CΛ VO I— cM in o oo in T O in VD O H o cΛ ιn ιn 'T in r- in vo m vo vo i— r-

CM CM CM CM CM CM CM CM OOOOOOOOOOOOO OOOOOOOOOOOOO

^ι « m m Φ ^ <3^ Φ α) lo o Φ m oo ffl o m ^» ^ 'll ^ φ v| ln o ^ (^ o ιo n Φ Φ o n o m c ^ n n o m ι m l N '» ιo ι») H H Ol ln r■ ^ ro τ vo vo r- ιn o Ln σ H H θ θ t- ro cn vo r- t— in ^ i H T cn t— o vo in co in H ∞ in oo t- H in o oo T Co as H VD CM H oo cn vD co oo o o H O

CΛ H O r- H H τ r0 in in T T VD 001O r- CΛ O r- CD O VD aj O (- ∞ 00 CM r- CN C0 H VD H H T V0 r- V0 CΛ 0^ in H 0000 t- CΛ H CD 00 CM O <Λ C0 r- in

^ m o Ol H ^l (1 '^^ι ιη _ln ( ( N N H O (n _fl v^ ln ^ ^ ω ^ ω ^ a ^ ιo l <» 1J M M flo σ) CΛ O H H H O N N H <^ι <ι^ι ^p Φ ^ ^ ^ ιxι ^o ^T Mi m -ir m m m m m m m m m m m m m m m m m m m -i m m m m in m m Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H rH rH H H H H H

O H O O VD O Λ in CM VD CO in t— O CΛ CO O ro cM H O in in in in cM oo oo oo m H VD oo oo o t- cn c M oo H CM t- o ro ro cM CO vo σv T cn vo o vo

VD CM in oo ro oo rH C CMM HH VVDD τT rΓ-- VVOO CCΛΛ τT rΓ-- [Γ—- CCΛΛ H CM VD o oo ro r- ro H H o 0o0 cCoO r 0o0 vD τ vo ro cD o vo ιn co oo r- ιn H o r- cn r- H VD oo vo o cΛ vD

T CM CM t— CΛ O T T OO O VO T in O VO VO CΛ CM H i- cn r- H ro H ro o oo vo r- vo r- o cM in in oo o oo cM m oo H t— oo in ro vo T oo in r- in o

_{T T} CO CM CM CM CM CM CM CO O H CΛ OO I— oo t— t— vo vo i— r— r— oo cn oo m in T CM H H CM O H CM CM CM CM CM CM T O Cn O OO r- CO Cn r— r- r- oo cn o o CM CM CM CM CM CM CM CM CM CM CM CM H H H ro

CM Vo r- T T i— H H cn t- H CM CM co t— vo co t— tH τ tn H τ τ t- cM τ τ r- cn τ ιn cn cM CM <Λ H τ cΛ τ ro rM in r ro τ t— oo ιn τ cM CΛ oo ι— rH rH CM

H ιfl v ^f Cn ln o ln ιo ι]l o ι- o o co ln ^ cD ^ N ιo (^ι o ^^ o o ^ lrι (^ι ιn m m ^ ^ v !O Λ lo m ^ m oo o H H o co N H v o ^ v M ^ι ιn o o c- oι θ N oo H N m « ιιι ^ ^ a m ιn ιo iii ιn H 9 tiι ιn ιn ^ ιn H iJi ^ oι θ N N v co ιn r H n « o ιrj ^ t ( >() ', o ι^,) oι r~ m o H

T OO rO UI I OO T in vO in CM H rO CM CM H rO T CM rO rO CM H H O O CM O CM H CM rH O H O CΛ CM rO H CM H H CM H CM CM rO CM rO CM CM O O Cn O CΛ cn cn cΛ CΛ cn cn cn cΛ cΛ cn cn cΛ cn cn cΛ CΛ CΛ cΛ cΛ CΛ CΛ CΛ cn cn cn cn cn cn cn cn cΛ cΛ cΛ CΛ cΛ co cn cΛ CΛ CΛ cΛ CΛ cΛ cΛ CΛ cΛ c^

co c» cD co cn cn cn cn cn cn cn cn o o o o o θ H H H H H H H H H H CM CM CM CM CM CM CM CM CM CM ro ro ro n oo oo τ τ τ τ τ ιn ιn ιn ιn ιn ιn ιn T T T T T T T T T T T T in in in in in in in in in in in in in in in in in in tn in in tn in in in in in in ro ro ro ro n ro ro ro ro oo oo oo oo ro n ro ro m oo ro m m oo co oo ro ro m m n ro n ro ro m o^ oo oo ro ro n ro ro oo oo ro ro oo oo oo oo oo ro ro oo ro n ro oo ro ro ro ro ro n oo oo oo ro ro oo ro oo oo ^ c H >< >< ⁽ D D D D D D D i- i- iH B: i- a; ⁽o w ω w m ω n κ n w M t n ra [n M n w ιn w (- β: (, (- i- (, c f fi ft Oj C-i -i Qj C-i CLi _H^ H^ H^ H^ ω ω ω ω ω ω ω w ω ω ω ω ω ω H M iH H H H M M M H HH H H M H H H H H M ω ω ω ω ω ω H-I H-I -I H-I PH PH I-H PH PH PH PH c CD O ri r rl rl rl rl rl rl cn cn cn cn cn cn x x x x x x x x x x x x x x x x x x x x cn cn cn cn cn tn ft ft fit < EH EH EH H EH EH EH

H CM CM H H CM CM H H CM CM ro o Aoozυ fto CQo CDυ Qυ Qoo ft CQ A CQ CD Q a ω fi Q C Q Q ω ω et n o ft cn fit cQ o Q ω ω Z O O o O O z υ z O z υ υ υ υ z υ z υ o z o υ o υ o z υ υ υ o O O O O O O v ln ιo ^ ι)o o> o H l n <r ιn ^ r^■ a) lJl O H C (^ ^ ln ιo ^ flo ι^ι O H N ( v ln Φ ^ a! ^ ^ ^ ^ ^ ^ co D C^l co o ω co o cD co o m m m σl <I\ ffl (^l σl 0^ o o o o o o o o o H H H H H H H H H H H H H H H H H H H H H H H H H H CM CM CM CM CM CM CM CM CM m m m m m m m m m m m m m m m m m m m m m m m m in m m m m

β H ^ H ^ ^ ^ ^ ^ ^ ^ ^ H H ^ H H ^ H H ^ ^ H H HH H H ^ ^ H ^ ^ rj rl rl rl H ^ H H H H H H H H i^ ^ ^ H ^ H r] oooooooooooooooooooooooooooooooooooooooooooooooooooooooo

C/i i Oi Ui Oi Cn Ui CJi C/i CJi ϋi C i υi M M I- M |ύ M t-O . W M N> W M cn cΛ en c cΛ c^jι υι c^jι c^jι αι υι π n ιb ω ι > μ θ cθ i m ui Λ ι iv)

000000000 000000000.00 O n n o o o z

Λ u M p ω ιv) p m w ω iv) m ui ι-, ω iv) H o σ D o to > oo C1o0 CrJo>zooπ Ooθoωozooo D DπoQoOo>zooπ Wn tsio t Mzπ σ co co co H ro w μ t N3 H^H ( μ M U M μ μ w ω co w G σ α α α α α α σ σ α - α σ α G t-< t^H t-^, t-^, -^, C-^, lr^< t-^, < < H H H H H H H t t l f t t t^l t^< H H H H H Hj o cn cn Q > > > > > _r _. > > > -- PI PI M Π M Π M PI > S o

Z Z Z Z fl 'rj 'O 'TJ t O 'D O H0 rQ rrj *O j r j rj α c α α α α σ σ t-¹ E pt th ϊtrs^, aρo Bρσ B5θ a_rθ a^ B!Λ a» BG Gπ Gpi πσ πα Bα πG pαi pnfl. irτ^βj jfrji ^Hrj jH_CJ) SH₀ ^β iro_α ω ω ω ω ω ω ω ω ω u ω ω ω u ω ω ω cij u ω ω ω ω ω ω ω ω ω u ω ω ω u ω ω ω ω u

00000000 000000 00000 (n W Ol UI W (n UI 01 U1 W W W lJ OI 01 Uι μ UI Ul I UI (Jl UI (fl CII I)1 1 UI 1 ϋl UI UI l)I UI Ul UI Cn

W M M M μ μ μ μ μ H H H μ H ιo iD Λ (β Φ Φ Φ ω ι. oι oo ffl α) (- αi vi si vi M M v) i (ji (iι iΛ iι> iιι oι i!i ui uι uι uι uι uι uι

OCI CO CO OO CO vD Φ Φ Φ Φ Φ Φ Φ Φ φ φ φ φ CO CD CD φ φ φ lO Φ Φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ CCI φ v φ φ φ φ φ φ OO OO OO Φ Φ J ^Qi ^ ^ Φ O μ O i u o o i μ μ μ O φ ^ iyi M M U b Ui ui ui ui M cα ^ βi ui ib b μ μ Ni u ^ fr b j co vj φ b ^ u ω in oo io o αι θ Φ W θ Λ μ Λ (Λ ϋi -j M θ -J Λ Φ M -J i Λ J Λ ^ fc A ω m ι ui Λ μ μ ιo βi Λ t. N m o w ιn θ (- Ui * φ θ o ui Λ W o N ι^Λ θ φ θι ft io ιc o o ιo fJ M (fl θ Φ U) θ i μ μ (. ω o w ijι θ Λ m φ vj ω (B i M U ffl o .j μ m w o Λ flo σι μ ^ φ (ιj i M si Λ Λ -J i Λ M (j> μ <jι uι iϋ μ θ ιMio iΛ J ω ω ιt> μ o co o ⁽> (i> ui ιt> o nD ln μ θ Λ -. l eΛ CΛ eo it- ΛJ VD o cn o — i c i eΛ Oi cπ co cπ oo cπ —i w c ⁾

M M U M N M M N U M N IVl N I IVl W I M M I I I VD VD O VO VO — 1 VO OO O OO Vθ σι OO VD vD -l — 1 00 VD o ro o μ μ ω μ N μ M μ M M U M u ω unj u n Λ ui ui Λ Ui oi iM μ μ o oo yι CΛ ιt!. CD O t ω cΛ -l CO VD M OO Cπ θ μ ( u a ffl Ui αi vi μ o ω _'vi θ ι<> (jι o> ι ιii U (ji ιi> Λ iιi u αι ιi) θ Λ M co co ιi ϋi N M μ ( oo o -J 00 l-' 0v> (Λ VD LJ -l l-' -3 M O C0 CΛ -l --» — 100 -3 — 1 — l O — J l-' O l-' tO OJ OO ifc. VO I-' OO ^ cn Λ I-' OO Cn CΛ it-. rO OO -l CΛ — l C0 (J O O 00 ιt-^, 00 O I-' CD

•J iv⁾ - ι tΛ Cjι <jj o vo ro -3 Cπ oo ω o cΛ OO I Φ N m φ m OO M ^ ^ l φ O ^ IVl vJ CO sJ U .-. UI I μ ui U ^ O O U ω l U CO μ μ vJ O -J

O O O I-' l-' l-' l-' O O I-' M I-' H' l-' l-' l-' l-' —1 —1 — 1 —1 — 1 —1 — 1 —1 -3 — 1 —1 -3 — 1 —1 — 1 —1 -3 — J — ! -3 CΛ -3 <Λ Cn CΛ Cn cΛ CΛ eΛ CΛ CΛ CΛ CΛ CΛ CΛ Cn

Φ Φ Φ Ol CΛ -J m φ φ H M Λ O H H M ω lV) A b U ι- Ui uι <- u< ι-, t u u ω ι o ) θ o θ θ co o co co >ι n σι -J m ιι>

M vi o u μ uι o Φ ω ω ⁾i ui N M Λ iD iιι w ^ ^ Λ co ω ^j m A Ui ω φ Ui M Λ θo Λ o o φ m ω ιfc U ιi!> ι ι oo o cn o cΛ eΛ Oi — i <n

U⁾ U> <> O 01 O M l 6 O O 'Α UI |JMl⁾ M l C0 M θ 00 UI O φ M ω ^ ffι 0l Ul θ μ 01 Φ M O U I O UI l> O O t> ] U^ CΛ >•-* C 1

W ιt-. c^ oι ι--' θ o .^ o ∞ -i α> ω ω eΛ ω .E-' θ io —ι -ι-» ω ι-^j υι c» ιt-^» ι-» o w eΛ OO VD — l OO Cn cΛ W μ μ μ μ H-> M M r-> H- I-¹ oooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooooooooo c c cΛ C c c c cn cn cn cn en cn cΛ c cn cΛ eΛ c ω ω ω ω w ω ω ω ω w cju ω ω ω ω ft ιl^V ι-, |VI CO Φ OO ffl »l ft (Λ U M Λ (Λ tJl Λ (11 0l W U1 U O M 01 ft * ft fc Ul Nl Ul ι-ι N μ θ Ul vl >I OB »I OI UI U U U) W

Cn CΛ μ ui o μ vi o w tiKm-. VD -3 CO I-¹ ω ω t ro J i- oo μ vi ui ui cn u o J- ui o u M ui M μ φ i μ μ cn ⁾ Φ ω I-¹ *• -3 o σι iv υι — l o u oo μ O CO O -3 Ui l-> ω -3 μ U U M IVI Λ OO Ul CO O vl b φ O O l M OO m O o vo ιt» cn o

ro o oo vo oo co in cM H H co cn r- cn cM CM in ro o H rO T CM σi cΛ ro vD t- CM in o o T oo in r- H vo CM vo o H ro ro H H T H H cs cn ιn H CO CM CM CM co cΛ CM ro cD VD oo ro o co cn o cn o H CD CΛ σi o o o o oo oo in o co co ro cM T CΛ en t— r- vo ro T ro H vo co H T in T ro t- T T t- in o

© o T in in o in in cM r- oo t— r- vo o^ oo σ^ cn in r- ∞ cn ∞ cn H co co o oo T T T in oo t- r- oo oo cΛ in <Λ r- H o ooo O T in vo in o H O O co in cM H CM vo vD vo vo vo vo vo vo vo vo vo vo vo vo vo vo in in in in in in vD in in vo in co vo vo vo T T T T 'T T T T 'T in T ιn τ τ τ τ ιn ιn ιn ιn ιn ιn ιn ιn ιn

H OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO P. rH rH rH rH rH rH

OO CΛ in VO CO CΛ OO CΛ τ vo t- H τ H CM r- t- ro cM Csi ιn ro co oo o oo «viι oo cM t- H H CO T 00 H H H r- OO CM H 'vJι r- CΛ CM CM r- CO O CM VO τ m τ H CM VO CO O H in CM f— H CΛ VO CΛ VO r- m t— CΛ VO rO VO CM CΛ CM VO H T in t— OO t— CM CM O CM CM ro T t— cM ro oo T oo oo H oo o cn i— in π t— cM r- m o

T co vo vD in cΛ r— t— in OO H O T CM CM rO OO H t— CM OO CM O CO OO VO O OO CM O in oo co ro r- T t— θ τ ιn τ t— <Λ CΛ H in o ιn cn τ co co cΛ oo τ H r- oo en ro vo in t- vo T in m ro vo vo vo co 00 O VO VD 00 O τ τ τ ro vD i— t— vD in τ oo m oo vo ιn τ co co cn o ιn vo ιn τ cM θo T T 00

O O O H O O O O H H H H O O O O O H O O O H O O O O O O O O O O O O O O ' O-^ ' O^ O'^ ' O-*' ' O-^ — H ^{ι r} O-. O^ O-^v O O O O O O ro co o ro in in t— T co o oo cM CM Λ CM H r- T cn H C0 VO VO 0 CM 00 VD 00 CΛ CΛ O in vo T CM H t- CM 00 T in r— τ ιn r- τ ι— VO T CM T OO I— π in oo

VD CΛ VO VD in t— O H O rO CΛ OO VD OO t- O CΛ T OO T VD VD C0 H CΛ H VD r m t- H H T H T T H T 00 00 o m CM O VD H O CΛ CM VD OO H OO CM CM CO cn r- o r- rH r- co m ro r- cM co cn co in oo r- H ro τ o o τ cM cn ιn τ τ oo vo cM T CM t- 00 o H H r- T CM co cΛ r- in σv tn o r- T CM CD H co oo cM αs oo O oo o oa cn cn H O CM H O H O H in i— ∞ ∞ t- t- t— oo in r- vo t— vo αs r- H CM ro oo oo oo cM H T in H H O cΛ O O CM rH ro H CM CM O O H

CM CM rO CM rO CM CM CM 0O 0O 000O rO 000O 0O CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM C^

H vo o H

O H lC w ro oD CM ro vo in r- in cΛ oo m co r- oo oo vo ιn vo τ ιn τ τ oo τ ro oo m cM τ cM τ vD t— t- ιn H H H oo oo τ o o H oo cM in cΛ <Λ co o vo vo r- r- oo r- co o o ωωnω∞ωωωωco o ωmωφα»∞ωφ∞ω ωco ωωmωωωωwcr ωcoωωωωω coωωωco

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM rO rO OO OO OO OO OO OO OO rO rO OO OO OO OO T T T T T T T T T T T T T T T T T T T T in in in in in o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o ro ro oo oo oo ro oo oo ro ro oo oo oo ro oo oo oo oo oo ro n ro n oo ro ro oo oo oo ro ro ro ro oo ro oo oo oo oo oo oo n ro ro ro

Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z D D D D D D D D D D D D D D D Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z D D D D D O O O O CD CD CD CD CD CD O CD CD CD CD CD ^{Q Q} α ^{Q Q Q Q} Q Q Q Q Q Q Q Q CD CD O CD CD O CD O CD O O CD CD O O O CD O O O Q Q ^Q Q Q CO W W CO CO CO CO CO CO tO CO CO CO CO W CO H H H H H H HH H H H H H M H H W tn CO CO W CO W CO CO CO W CO CO C C CO CO CO CO CO H M H H H

C0 C CO C C0 C0 H CM CO CO CO co co co cn cn cn in vo H oo T in vo H H CM Oo cM T in vo H CM ro T in vo cM oo in vo vo H CM ΓO H CM ro T in vo H rO T in VO H H CM CO CM T in VO H CM CO T in υ υ z o o o o o co o o o co o o o υ υ υ υυ υoo oo o c o o o O O O z o o o o o coo o o coo o o o υ υ o υ m a ^ oo ol O H N ⁽^ ^ ιn Φ ^ oo n o H (^ι t ^ ln ^ ^ co ιl^ O H N m » m Φ ^ α) (Λ O H N n 'l^| ln ^o ^ ω ol O H ^ι n « ιrJ φ ^ oo m o vD vD vo vo vD t— r- r- r- r- r- r- r- t~ t— ∞ co co co co co co co co co cΛ cn cn cn cn cn cn cΛ cΛ cΛ o o o o o o o o o o rH H H H H H H H H H CM

CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CN CM rO r^

00 mmm minin mm mmmmmminmmmmmmmmm mmm mmmm immmin mmmmmmm mmmmmm rH ΣΣ ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ∑∑ΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ∑Σ∑∑∑∑∑∑∑∑∑∑∑∑∑∑∑ o E^Ho^Ho^H Eo^HoE^HoE^HoE^HoE^HoE^HoE^HoE^HoE^HoEHo^HoEHoEHoHoHoHoHoHoHoHoEHoE^HoHoEHoHoHoHoHoEHoHoHoHoHoHoEHoEHoHoEHoHoEHoEHoEHoEHoEHoHoEHoEHoHoHoEHoEHoEHoEH

O A A ft A A A A A A A A A A A A A A ft A A A A A A A A A A A A A A A A A A A A A A A A A fZ A ft A A A A A A A A A A it

rt rt t- ro va in o vo T in oo in o in m O T H co oo cΛ oo H cn eΛ t— OO CD t— T rH OO I— t— in CO t- VO VO σv O CΛ T T CΛ

H in T T CM rH OO CM OO rO CO Cn cD CM T CO CM H in

CΛ £ ιn ιn m ιn m ιn m m ιn m r- r- t— r- t— r- oo oo φ

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOO υ H OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOO

PM

^ m ι m N N ^^ ^^ o m ω ^ ^l βl Φ N H ^ m ^ lI! ^ (Jl eo m H co a m O H ^ N tι Λ m ^ O ( N (- Φ ro ^ o ^ oo o (ι ^ Λ O N l 01 rO H o O T O H O in o t— co t— co cM CM in τ oo oo o τ τ cM cn τ ro cM ro cΛ vo τ cM α} CΛ CM θo o ιn cM t- oo oo cM oo o o cΛ ro t- co ro t- ιn ιn τ α) O Λ m o m ( ιη φ ^ c^ Λflo n o n H n Nf r■ m ln o ι N ln H O o ιo ι N ln (ι ι»1 Φ ^ ^ι Λ ^ N H (^,) o o (^ ϋO N H m

CM in oo cM ro cM vo c- in vo co o o o cn cn o co cM rH oo r- H H H CM VD in m vo vo ιn m t- r- oo τ ιn t— oo cΛ co ro τ cM VD r- t— co in oo oo vo oo vD T

O O O O O O O O O O CΛ o o o cn cn o cΛ o o cΛ cΛ o o o o cn cn cn cΛ cn m m cn cn cn cn cΛ cn d cn cΛ cn cn cn cn cn cΛ cΛ cΛ CΛ CΛ cΛ cΛ cn cn ro T T CΛ in VD rO VD OO VD OO I— VD in CΛ T in Cn r- CΛ CM OO T CΛ CO in H CΛ co o o r- t- o t- t- oo H CM θo oo ιn cn m τ cΛ oo vD T CO CM in T CΛ m D r- VD T H CM O VD VO T Cfl CO O I- T T VO CΛ in VO OO OO T H O in H H in T oo vo T CΛ OO H OO in CΛ H OO m OO Λ Cn CΛ VD CM O OO T CD VO O O CΛ o oo T oo cΛ O CM oo co oo T in o o vo σi ro in o o vo cM oo in oo cM T CΛ T cn co H vo in ro vo vo H CΛ oo in m cn H vo cM H VD T T [— VD r-

O C CΛ CM CΛ H O CM CM T H H CM CM CM H H O CM rθ H O H <Λ H H H O H CM r- CΛ Cn cn ∞ t- CΛ H t-- VD ∞ O H H O M 'T in VO CO VO rθ T in r- T CM CM H CM H CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM CM H CM CM CM CM CM CM rH H H H H H H CM H H H CM CM CM CM H H H H H H H H H H H rθ CO H VO VO T t- CM H Cn τ O CΛ CM T H rθ H O ιn i- rθ CD O T CM CO CO CO VO ιn ιn VD H ιn H OO Cn t- CΛ VD CM T CM I— CM t— CD H OO in rO CM OO t- CΛ

Ol O ln H o n v Ol ln ln (n H ^I| Φ O ^ ^ H ln ^~ (D N ιn ffl N l O ^ H ^ ι co v O (Iι ^ι ιn ol (! • ιι) n H ιll H o lI) lβ ιn '» ι ^l N ( cΛ H O O ■* ^ ιs (O Φ ln H ^ a H fl a) _'* n N m ln ιo M ιn (Il ^ Φ ^ <Il aι ι» ol ^ lD ^■^f ^{• ■}» N n ^ ^ o ^ o n Ol ^ ri (^ι ιJ^ ^ n 1

H oo ∞ o cM CM VD r- ιn vD Ln τ ιn r- r- oo ro τ ιn r- vD oo cM CM θ CM co ι- cΛ i— cM CM -T T T in cM T ro vD in H CM H O CΛ o o o cn o o t- H H m ^ ^ ro ω ω ι- r■ ^ r• ^ r• ^ ^ ^ ^^ r~ r- ι- r- ^ I- I- ^- ^ l~ ^ ^ ^ ^ ^ - ^- r■ ι-• r- ^ ^ ^ r■ r^ ^ ι- ^ ^ ^ ^ ^ ^ ^ r• r-

m ιn m m Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ r> ^ ^ ^ ^ ^ ^ ^ r■ ^ ^ ^ ^ ^ co co ω cD ω co (D ω cD oo co o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o ro ro co oo ro ro ro m ro m oo m ro oo ro ro n oo m oo oo m oo oo oo oo ro ro ro oo ro ro ro m r^

D D D D D D D D D D Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z D D D D D D D D D D D D D D D Z Z Z Z Z Z Z Z Z Z Z Q Q D Q ^{Q Q Q Q} Q ^Q O CD CD CD CD CD CD O CD O CD CD CD CD CD O CD CD tD O Q ^Q Q Q ^Q Q Q Q Q D Q Q Q Q Q CD CD O CD O CD CD O O CD CD H H H H H M H H H H CO CO CO W CO CO CO CO CO CO CO CO CO CO CO tO CO CO CO CO M H H H M M M H H H H H H H H CO CO CO CO CO CO C CO CO CO CO co co co co co co co co co H CM CO CO CO

CD CM 00 in VD O H CM OO H CM OO T in VD H OO T in VD H H CM rO C .M. T. i_n. C_D H CM rO T , i_n. V_D C.M. O.O. i_n. V_D V_O H t ro H C o T i vo H OO T LΠ O O O O O co o o o υ υ υ υ z o o oo o c o ' o^ o~^, 'c'o'¹ ^o^,'o^ ^o ^lo"^{v ■}o"^, 'υ^■■ 'υ"^{l r}υ'^, 'υ"^l 'o^'o^ 'o^ 'o^'o^ cooo o υ υυυ oo zoo oo

H CM oo T in cD t— oo cn o H CM rO T in io t— oo cΛ O H CM r T in vo t— TO cn o H CM rO in o t- ∞ c O H CM oo T in Λ r- oo c O H CM co T i vD

N N N l N c^l N N N n ιo ( ιη (n ι n ιn ιo n ^ v ^ ^ v ^ ^ ^ ^ ^^ m m Λ m m m m Φ Φ Φ Φ ^ ^ ^ ^ ^ ro ro ro oo ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro n ro oo ro ro ro ro ro ro ro oo oo oo m

00 m m m m m m m m m m m m m in m m m m m m m m m m m m m m m m m m m m m m m m -i m in m m m in rH vo rH rH ΣΣΣ o oooΣoΣoΣoΣooΣoΣΣooΣoΣoΣoΣoΣΣ Σ HoEHoΣ HoΣΣ HoEHoΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣΣ o EH EH EH H EH H EH EH EH EH H EH EH EH E HoHoEHoEHoEHoHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEHoEH

A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A

Table 6

ATOM 5377 06 SGN 308 71, .085 15.714 93.059 1.00 97.55

ATOM 5378 SI SGN 308 71, .661 12.414 98.738 1.00101.81

ATOM 5379 OIS SGN 308 71, .720 11.295 97.822 1.00101.81

ATOM 5380 02S SGN 308 71. .485 11.950 100.088 1.00101.81

ATOM 5381 03S SGN 308 72 .886 13.189 98.639 1.00101.81

ATOM 5382 S2 SGN 308 72. .736 16.256 92.593 1.00 98.46

ATOM 5383 04S SGN 308 72. .700 17.607 92.120 1.00 97.88

ATOM 5384 05S SGN 308 73, .216 15.397 91.547 1.00 97.59

ATOM 5385 06S SGN 308 73, .612 16.123 93.731 1.00 96.16

ATOM 5386 Cl UAP 1301 99, .984 28.369 114.585 1.00 63.64

ATOM 5387 C2 UAP 1301 98, .784 28.735 115.438 1.00 63.25

ATOM 5388 C3 UAP 1301 98. .294 30.192 115.433 1.00 64.22

ATOM 5389 C4 UAP 1301 98, .524 30.968 114.107 1.00 64.45

ATOM 5390 C5 UAP 1301 99, .311 30.177 113.059 1.00 64.79

ATOM 5391 C6 UAP 1301 99, .312 30.805 111.668 1.00 65.66

ATOM 5392 02 UAP 1301 97, .709 27.939 115.078 1.00 61.67

ATOM 5393 03 UAP 1301 98, .934 30.847 116.486 1.00 63.94

ATOM 5394 05 UAP 1301 99, .907 28.911 113.266 1.00 63.51

ATOM 5395 061 UAP 1301 98, .751 31.902 111.474 1.00 65.52

ATOM 5396 062 UAP 1301 99, .869 30.146 110.766 1.00 66.61

ATOM 5397 S UAP 1301 96, .989 27.084 116.416 1.00 59.96

ATOM 5398 OIS UAP 1301 95, .599 27.032 116.168 1.00 59.72

ATOM 5399 02S UAP 1301 97, .243 27.788 117.649 1.00 60.99

ATOM 5400 03S UAP 1301 97, .572 25.776 116.405 1.00 59.85

ATOM 5401 Cl SGN 1302 105, .076 27.945 115.940 1.00 66.27

ATOM 5402 C2 SGN 1302 104, .590 28.121 114.499 1.00 65.68

ATOM 5403 C3 SGN 1302 103, .305 28.937 114.471 1.00 64.98

ATOM 5404 C4 SGN 1302 102. .273 28.162 115.267 1.00 64.94

ATOM 5405 C5 SGN 1302 102, .753 28.002 116.704 1.00 65.77

ATOM 5406 C6 SGN 1302 101. .712 27.239 117.521 1.00 66.32

ATOM 5407 N SGN 1302 105. .593 28.906 113.815 1.00 66.15

ATOM 5408 01 SGN 1302 105. .374 29.247 116.443 1.00 67.50

ATOM 5409 03 SGN 1302 102. .858 29.086 113.138 1.00 64.85

ATOM 5410 04 SGN 1302 101. ,080 28.882 115.277 1.00 64.61

ATOM 5411 05 SGN 1302 104. .021 27.294 116.694 1.00 65.72

ATOM 5412 06 SGN 1302 102. .251 26.030 118.025 1.00 67.95

ATOM 5413 SI SGN 1302 106. .415 28.196 112.415 1.00 66.53

ATOM 5414 OIS SGN 1302 105. .883 28.790 111.214 1.00 65.81

ATOM 5415 02S SGN 1302 106. .164 26.789 112.436 1.00 65.66

ATOM 5416 03S SGN 1302 107, .837 28.429 112.508 1.00 65.29

ATOM 5417 S2 SGN 1302 101. .822 25.610 119.680 1.00 69.68

ATOM 5418 04S SGN 1302 102. .732 26.252 120.587 1.00 70.12

ATOM 5419 05S SGN 1302 101. ,904 24.179 119.820 1.00 68.94

ATOM 5420 06S SGN 1302 100. ,465 26.036 119.920 1.00 69.87

ATOM 5421 Cl IDU 1303 107. ,412 32.109 117.309 1.00 70.24

ATOM 5422 C2 IDU 1303 107. .919 30.853 116.576 1.00 70.77

ATOM 5423 C3 IDU 1303 107. .641 29.512 117.278 1.00 69.95

ATOM 5424 C4 IDU 1303 106. ,154 29.370 117.637 1.00 69.26

ATOM 5425 C5 IDU 1303 105. ,701 30.661 118.318 1.00 69.74

ATOM 5426 C6 IDU 1303 104. ,297 30.559 118.843 1.00 70.20

ATOM 5427 02 IDU 1303 107. .390 30.815 115.289 1.00 73.31

ATOM 5428 03 IDU 1303 108. ,438 29.393 118.402 1.00 70.32

ATOM 5429 05 IDU 1303 106. ,078 31.915 117.781 1.00 69.63

ATOM 5430 061 IDU 1303 104. .088 29.945 119.899 1.00 70.68

ATOM 5431 062 IDU 1303 103. ,458 31.288 118.281 1.00 70.21

ATOM 5432 S IDU 1303 108. ,350 31.678 114.099 1.00 75.41 Table 6

ATOM 5433 OIS IDU 1303 108 .386 33.051 114.484 1.00 75.11

ATOM 5434 02S IDU 1303 107 .730 31.538 112.814 1.00 75.13

ATOM 5435 03S IDU 1303 109 .661 31.083 114.128 1.00 74.40

ATOM 5436 Cl SGN 1304 108 .865 35.363 121.338 1.00 73.27

ATOM 5437 C2 SGN 1304 108 .137 34.041 121.685 1.00 71.39

ATOM 5438 C3 SGN 1304 108 .445 32.956 120.649 1.00 71.09

ATOM 5439 C4 SGN 1304 108 .034 33.464 119.263 1.00 71.78

ATOM 5440 C5 SGN 1304 108 .843 34.746 118.973 1.00 73.44

ATOM 5441 C6 SGN 1304 108 .516 35.340 117.611 1.00 75.39

ATOM 5442 N SGN 1304 108 .696 33.559 122.927 1.00 68.96

ATOM 5443 01 SGN 1304 110 .283 35.211 121.488 1.00 75.58

ATOM 5444 03 SGN 1304 107 .738 31.776 120.988 1.00 69.69

ATOM 5445 04 SGN 1304 108 .348 32.447 118.309 1.00 70.53

ATOM 5446 05 SGN 1304 108, .520 35.735 119.988 1.00 73.79

ATOM 5447 06 SGN 1304 107 .318 36.107 117.720 1.00 77.19

ATOM 5448 SI SGN 1304 108, .114 34.231 124.446 1.00 66.75

ATOM 5449 OIS SGN 1304 108. .335 35.645 124.481 1.00 67.47

ATOM 5450 02S SGN 1304 108, .833 33.590 125.494 1.00 66.13

ATOM 5451 03S SGN 1304 106. .720 33.957 124.574 1.00 67.93

ATOM 5452 S2 SGN 1304 106. .061 35.870 116.506 1.00 78.60

ATOM 5453 04S SGN 1304 105, .417 37.125 116.243 1.00 79.30

ATOM 5454 05S SGN 1304 105, .107 34.932 117.038 1.00 78.89

ATOM 5455 06S SGN 1304 106, .671 35.336 115.310 1.00 78.63

ATOM 5456 Cl IDU 1305 114, .018 35.900 122.301 1.00 83.03

ATOM 5457 C2 IDU 1305 113, .051 35.540 123.454 1.00 80.20

ATOM 5458 C3 IDU 1305 111. .573 35.996 123.419 1.00 78.83

ATOM 5459 C4 IDU 1305 110, .999 36.329 122.025 1.00 77.88

ATOM 5460 C5 IDU 1305 112, .092 36.738 121.040 1.00 79.17

ATOM 5461 C6 IDU 1305 111. .548 37.212 119.687 1.00 79.44

ATOM 5462 02 IDU 1305 113, ,215 34.215 123.956 1.00 77.79

ATOM 5463 03 IDU 1305 111. .404 37.056 124.273 1.00 78.31

ATOM 5464 05 IDU 1305 113. ,352 36.113 121.058 1.00 80.89

ATOM 5465 061 IDU 1305 110. ,438 37.771 119.627 1.00 79.07

ATOM 5466 062 IDU 1305 112. .215 36.905 118.679 1.00 78.65

ATOM 5467 S IDU 1305 112. ,571 32.870 123.007 1.00 75.82

ATOM 5468 OIS IDU 1305 112. ,705 33.181 121.627 1.00 76.64

ATOM 5469 02S IDU 1305 111. .205 32.675 123.345 1.00 76.15

ATOM 5470 03S IDU 1305 113. ,350 31.733 123.340 1.00 73.63

ATOM 5471 Cl SGN 1306 118. ,222 36.383 120.003 1.00 98.21

ATOM 5472 C2 SGN 1306 118. ,143 35.478 121.253 1.00 98.39

ATOM 5473 C3 SGN 1306 116. ,756 35.509 121.875 1.00 97.23

ATOM 5474 C4 SGN 1306 116. .298 36.952 122.158 1.00 94.94

ATOM 5475 C5 SGN 1306 116. .362 37.752 120.844 1.00 96.28

ATOM 5476 C6 SGN 1306 115. 932 39.207 121.039 1.00 97.55

ATOM 5477 N SGN 1306 118. ,381 34.086 120.796 1.00 99.10

ATOM 5478 01 SGN 1306 117. ,465 35.806 118.949 1.00 99.21

ATOM 5479 03 SGN 1306 116. 745 34.697 123.043 1.00 99.21

ATOM 5480 04 SGN 1306 114. .946 36.939 122.709 1.00 89.42

ATOM 5481 05 SGN 1306 117. .728 37.702 120.348 1.00 97.38

ATOM 5482 06 SGN 1306 117. 053 40.079 120.827 1.00 98.80

ATOM 5483 SI SGN 1306 117. 056 32.951 120.302 1.00 99.45

ATOM 5484 OIS SGN 1306 115. .892 33.658 119.812 1.00 99.12

ATOM 5485 02S SGN 1306 116. 723 32.178 121.456 1.00 99.28

ATOM 5486 03S SGN 1306 117. 543 32.068 119.277 1.00 99.02

ATOM 5487 S2 SGN 1306 117. 386 40.657 119.172 1.00 99.96

ATOM 5488 04S SGN 1306 118. 013 41.944 119.241 1.00 99.55

ATOM 5489 05S SGN 1306 116. 148 40.755 118.444 1.00 99.37

ATOM 5490 06S SGN 1306 118. 244 39.703 118.514 1.00100.23

Claims

CLAIMS We claim:

1. A crystal comprising a polypeptide which includes an extracellular domain of a receptor protein tyrosine kinase.

2. The crystal of claim 1 wherein the extracellular domain comprises one or more Ig-like domains.

3. The crystal of claim 2, wherein the receptor protein tyrosine kinase is a fibroblast growth factor receptor.

4. The crystal of claim 3, wherein the extracellular domain comprises Ig-like domain 2 and Ig-like domain 3 and does not comprise Ig-like domain 1.

5. The crystal of claim 1 , wherein the fibroblast growth factor receptor is fibroblast growth factor receptor 1.

6. The crystal of claim 1, wherein polypeptide comprises amino acid acid residues 142- 365 of fibroblast growth factor receptor 1.

7. The crystal of claim 1, wherein the polypeptide comprises amino acid acid residues 150-360 of FGFRl having the sequence shown in Figure 4.

8. The crystal of claim 1 further comprising a ligand bound to the receptor protein tyrosine kinase.

9. The crystal of claim 8 wherein the receptor protein tyrosine kinase is fibroblast growth factor receptor 1 and the ligand is FGFl .

10. The crystal of claim 9 wherein FGFl has an amino acid sequence as shown in Figure 17.

11. The crystal of claim 9 defined by the atomic structural coordinates of Table 2.

12. The crystal of claim 11 belonging to the tetragonal space group PI, and having unit cell dimensions of a=b=98.5 A, c=197.0 A.

13. The crystal of claim 8, wherein the receptor protein tyrosine kinase is fibroblast growth factor receptor 1 and the ligand is FGF2.

14. The crystal of claim 13 wherein FGF2 has an amino acid sequence as shown in Figure 17.

15. The crystal of claim 13 defined by the atomic structural coordinates of Table 1.

16. The crystal of claim 13 belonging to the tetragonal space group P41212, and having unit cell dimensions of a=62.55 A, b=64.06 A, c=64.14 A, α=93.40°, β=l 11.17°, and γ=97.18°.

17. The crystal of claim 1 further comprising at least one heavy atom.

18. A three-dimensional representation of the structure of the extracellular domain of claim 1 or 8.

19. The crystal of claim 1 or 8 wherein the receptor protein tyrosine kinase is a mutant receptor protein tyrosine kinase.

20. The crystal of claim 8 wherein the ligand is a mutant ligand.

21. The crystal of claim 1 wherein the fibroblast growth factor receptor is fibroblast growth factor receptor 2.

22. The crystal of claim 21 wherein polypeptide comprises amino acid acid residues 147- 366 of fibroblast growth factor receptor 2.

23. The crystal of claim 22 wherein polypeptide comprises an amino acid sequence for fibroblast growth factor receptor 2 residues 150-360 as shown in Figure 4.

24. The crystal of claim 8 wherein the receptor protein tyrosine kinase is fibroblast growth factor receptor 2 and the ligand is FGF2.

25. The crystal of claim 24 wherein FGF2 has an amino acid sequence as shown in Figure 17.

26. The crystal of claim 24 defined by the atomic structural coordinates of Table 3.

27. The crystal of claim 24 belonging to the triclinic space group P 1 , and having unit cell dimensions of a= 72.20 A, b=71.68 A, c=90.92 A, α=90.53°, β=89.98°, and γ=89.99°.

28. A crystal comprising a polypeptide that includes a receptor binding core of a stem cell factor.

29. The crystal of claim 28 wherein the receptor binding core ofthe polypeptide comprises a four-helix bundle.

30. The crystal of claim 29 wherein the receptor binding core ofthe polypeptide further comprises two β strands.

31. The crystal of claim 30 comprising a homodimer of the polypeptide.

32. The crystal of claim 31 comprising a non-covalent homodimer ofthe polypeptide.

33. The crystal of claim 32 wherein said crystal is orthorhombic and has unit cell dimensions a = 72.47A, b = 83.45 A and c = 89.15 A.

34. The crystal of claim 33 wherein said crystal is monoclinic.

35. The crystal of claim 34 defined by the atomic structural coordinates of Table 4.

36. The crystal of claim 32 comprising a non-covalent homodimer of a polypeptide including amino acid residues 1-141 of the stem cell factor.

37. The crystal of claim 32 wherein the non-covalent homodimer has C2 symmetry.

38. The crystal of claim 29 further comprising a ligand bound to the receptor binding core.

39. The crystal of claim 38 wherein the ligand is a receptor protein tyrosine kinase.

40. The crystal of claim 39 wherein the receptor protein tyrosine kinase is a c-kit polypeptide.

41. A three-dimensional representation of a structure of a polypeptide which includes a receptor binding core of a stem cell factor.

42. The three-dimensional representation of claim 41 in computer readable form.

43. A computer based system for depicting and analyzing a molecular structure which comprises a polypeptide which includes an extracellular domain of a receptor protein tyrosine kinase, said system comprising:

(a) a data storage device storing structural data from the molecular structure;

(b) a computer processor coupled to said memory, said processor generating processed output on said data using a set of programmed instructions; and

(c) a display device coupled to said processor, said display rendering multidimensional images ofthe molecular structure according to said processed output.

44. The system of claim 43, wherein said data storage device comprises:

(i) at least one first-type storage region comprising a set of spatial coordinates ofthe molecular structure in a multi-dimensional space; and

(ii) at least one second-type storage region comprising a representation of characteristics of a plurality of amino acids ofthe molecular structure, wherein said second-type storage region is logically associated with said first-type storage region to support data processing in said processor.

45. The system of claim 43, wherein said processor (i) accesses the structural data in said memory, and (ii) generates image signals for depicting a visual image ofthe molecular structure in a multi-dimensional space corresponding to a set of structural data points in said data storage device, and wherein said image signals are the processed output.

46. The system of claim 43, wherein said display (i) receives said processed output, and (ii) renders a visual image of said molecular structure on a computer screen according to said processed output.

47. The system of claim 43, further comprising:

(i) a storage device for storing data of geometric arrangements of characteristics of a composition other than the molecular structure, wherein said storage device is coupled to said processor; and

(ii) an operator interface for receiving instructions from an operator, wherein said interface is coupled to said processor, wherein said processor generates additional image signals for depicting a visual representation of said composition relative to the visual image of said polypeptide, according to said instructions from the operator interface, said additional image signals being the additional processed output.

48. The system of claim 43, wherein the structural data are set forth in Table 1, 2, 3 or 6.

49. A memory that stores information for generating a visual display of a a molecular structure which comprises a polypeptide which includes an extracellular domain of a receptor protein tyrosine kinase, said memory comprising:

(i) at least one first-type storage region, comprising a set of spatial coordinates ofthe molecular structure in a multi-dimensional space; and

(ii) at least one second-type storage region, comprising a representation of a characteristic of a plurality of amino acids ofthe molecular structure; wherein said second-type storage region is associated with said first-type storage region to represent a geometric arrangement ofthe molecular structure in a multi-dimensional space.

50. The memory of claim 49, wherein said second-type storage regions are logically associated with said first-type storage regions to represent a geometric arrangement of at least one characteristic ofthe extracellular domain ofthe molecular structure in a multidimensional space.

51. The memory of claim 50, wherein the spatial coordinates are set forth in Table 1 , 2, 3 or 6.

52. A computer based system for depicting and analyzing a molecular structure which includes a stem cell factor or portion thereof, comprising:

(a) a data storage device storing structural data from the molecular structure;

(b) a computer processor coupled to said memory, said processor generating processed output on said data using a set of programmed instructions; and

(c) a display device coupled to said processor, said display rendering multidimensional images ofthe molecular structure according to said processed output.

53. The system of claim 52, wherein the molecular structure comprises a polypeptide which includes a stem cell factor receptor binding core.

54. A method of determining a three dimensional structure of a receptor protein tyrosine kinase extracellular domain of unknown structure, the method comprising:

(a) aligning an amino acid sequence ofthe receptor protein tyrosine kinase extracellular domain of unknown structure with an amino acid sequence of a receptor protein tyrosine kinase extracellular domain having known atomic structural coordinates, wherein the alignment is achieved by matching homologous regions of the amino acid sequences;

(b) transferring a computer representation of each ofthe homologous amino acids from the known atomic structural coordinates to a computer representation of a structure ofthe corresponding amino acids in the receptor protein tyrosine kinase extracellular domain of unknown structure to provide a receptor protein tyrosine kinase extracellular domain structure; and

(c) determining the three dimensional structure ofthe receptor protein tyrosine kinase extracellular domain of unknown structure by determining a low energy conformation ofthe resulting receptor protein tyrosine kinase extracellular domain structure.

55. A method of determining a three dimensional structure of a receptor protein tyrosine kinase extracellular domain of unknown structure, the method comprising:

(a) determining the positions of atoms in the unit cell of a crystal comprising the receptor protein tyrosine kinase extracellular domain of unknown structure by matching a diffraction data set obtained from the crystal with a diffraction data set obtained from a crystal comprising a receptor protein tyrosine kinase extracellular domain having known atomic structural coordinates to provide a receptor protein tyrosine kinase extracellular domain structure; and

(b) determining the three dimensional structure ofthe receptor protein tyrosine kinase extracellular domain of unknown structure by determining a low energy conformation ofthe resulting receptor protein tyrosine kinase extracellular domain structure.

56. A method of determining a three dimensional structure of a receptor protein tyrosine kinase extracellular domain of unknown structure, the method comprising:

(a) determining the secondary structure ofthe receptor protein tyrosine kinase extracellular domain of unknown structure using NJMR data; and

(b) determining the three dimensional structure ofthe receptor protein tyrosine kinase extracellular domain of unknown structure by simplifying the assignment of through- space interactions of amino acids using the atomic structural coordinates of a receptor protein tyrosine kinase extracellular domain having known atomic structural coordinates.

57. A three dimensional structure of a receptor protein tyrosine kinase extracellular domain determined using any one ofthe methods of claims 54 to 56.

58. A method of identifying a modulator of receptor protein tyrosine kinase function, the method comprising:

(a) providing a three dimensional representation ofthe atomic structural coordinates of a receptor protein tyrosine kinase and docking a computer representation of a compound, ligand, or ligand analog from a computer data base into a binding site on the receptor protein tyrosine kinase to provide a complex;

(b) determining a conformation ofthe complex with a favorable geometric fit and one or more favorable complementary interactions;

(c) identifying a compound, ligand, or ligand analog that best fits the receptor protein tyrosine kinase binding site as a potential modulator of receptor protein tyrosine kinase function;

(d) administering the potenial modulator to cells; (e) comparing the level of receptor protein tyrosine kinase phosphorylation between cells not administered the potential modulator and cells administered the potential modulator; and

(f) identifying the potential modulator as a modulator of receptor protein tyrosine kinase function based on the difference in the level of receptor protein tyrosine kinase phosphorylation.

59. A method of identifying a modulator of receptor protein tyrosine kinase function, the method comprising:

(a) modifying a three dimensional representation of a receptor protein tyrosine kinase having a compound, ligand, or ligand analog bound to it to provide a complex, wherein the three dimensional representations ofthe compound, ligand, or ligand analog and the receptor protein tyrosine kinase are defined by atomic structural coordinates;

(b) determining a conformation ofthe complex with a favorable geometric fit and one or more favorable complementary interactions;

(c) identifying a modified compound, ligand, or ligand analog that best fits the receptor protein tyrosine kinase as a potential modulator of receptor protein tyrosine kinase function;

(d) administering the potenial modulator to cells;

(e) comparing the level of receptor protein tyrosine kinase phosphorylation between cells not administered the potential modulator and cells administered the potential

. modulator; and

(f) identifying the potential modulator as a modulator of receptor protein tyrosine kinase function based on the difference in the level of receptor protein tyrosine kinase phosphorylation.

60. A method of identifying a modulator of receptor protein tyrosine kinase function, the method comprising:

(a) providing a three dimensional representation of a compound, ligand, or ligand analog complexed with a receptor protein tyrosine kinase, where the three dimensional representations ofthe compounds, ligands, or ligand analogs and the receptor PTK are defined by atomic structural coordinates; (b) searching a data base for a compounds, ligand, or ligand analog similar to the complexed compound, ligand, or ligand analog using a compound searching computer program;

(c) identifying the compound, ligand, or ligand analog similar to the complexed compound, ligand, or ligand analog as a potential modulator of receptor protein tyrosine kinase function;

(d) administering the potenial modulator to cells;

(e) comparing the level of receptor protein tyrosine kinase phosphorylation between cells not administered the potential modulator and cells administered the potential modulator; and

(f) identifying the potential modulator as a modulator of receptor protein tyrosine kinase function based on the difference in the level of receptor protein tyrosine kinase phosphorylation.

61. A method of identifying a modulator of receptor protein tyrosine kinase function, the method comprising:

(a) providing a three dimensional representation of a compound, ligand, or ligand analog complexed with a receptor protein tyrosine kinase, wherein the three dimensional representations ofthe compounds, ligands, or ligand analogs and the receptor protein tyrosine kinase are defined by atomic structural coordinates;

(b) identifying the compound, ligand, or ligand analog as a potential modulator by replacing portions ofthe compound, ligand, or ligand analog complexed with the receptor protein tyrosine kinase with similar chemical structures from a data base using a compound construction computer program, wherein the representations ofthe compounds are defined by structural coordinates;

(c) administering the potenial modulator to cells;

(d) comparing the level of receptor protein tyrosine kinase phosphorylation between cells not administered the potential modulator and cells administered the potential modulator; and

(e) identifying the potential modulator as a modulator of receptor protein tyrosine kinase function based on the difference in the level of receptor protein tyrosine kinase phosphorylation.

62. A method of identifying a modulator of receptor protein tyrosine kinase function, the method comprising:

(a) providing a three dimensional representation ofthe atomic structural coordinates of a receptor protein tyrosine kinase and docking a computer representation of a compound, ligand, or ligand analog from a computer data base into a binding site on the receptor protein tyrosine kinase to provide a complex;

(b) determining a conformation ofthe complex with a favorable geometric fit and one or more favorable complementary interactions;

(c) identifying a compound, ligand, or ligand analog that best fits the receptor protein tyrosine kinase binding site as a potential modulator of receptor protein tyrosine kinase function;

(d) administering the potenial modulator to cells;

(e) comparing the level of cell growth between cells not administered the potential modulator and cells administered the potential modulator; and

(f) identifying the potential modulator as a modulator of receptor protein tyrosine kinase function based on the difference in cell growth.

63. A method of identifying a modulator of receptor protein tyrosine kinase function, the method comprising:

(a) modifying a three dimensional representation of a receptor protein tyrosine kinase having a compound, ligand, or ligand analog bound to it to provide a complex, wherein the three dimensional representations ofthe compound, ligand, or ligand analog and the receptor protein tyrosine kinase are defined by atomic structural coordinates;

(b) determining a conformation ofthe complex with a favorable geometric fit and one or more favorable complementary interactions;

(c) identifying a modified compound, ligand, or ligand analog that best fits the receptor protein tyrosine kinase as a potential modulator of receptor protein tyrosine kinase function;

(d) administering the potenial modulator to cells;

(e) comparing the level of cell growth between cells not administered the potential modulator and cells administered the potential modulator; and (f) identifying the potential modulator as a modulator of receptor protein tyrosine kinase function based on the difference in cell growth.

64. A method of identifying a modulator of receptor protein tyrosine kinase function, the method comprising:

(a) providing a three dimensional representation of a compound, ligand, or ligand analog complexed with a receptor protein tyrosine kinase, where the three dimensional representations of the compounds, ligands, or ligand analogs and the receptor PTK are defined by atomic structural coordinates;

(b) searching a data base for a compounds, ligand, or ligand analog similar to the complexed compound, ligand, or ligand analog using a compound searching computer program;

(c) identifying the compound, ligand, or ligand analog similar to the complexed compound, ligand, or ligand analog as a potential modulator of receptor protein tyrosine kinase function;

(d) administering the potenial modulator to cells;

(e) comparing the level of cell growth between cells not administered the potential modulator and cells administered the potential modulator; and

(f) identifying the potential modulator as a modulator of receptor protein tyrosine kinase function based on the difference in cell growth.

65. A method of identifying a modulator of receptor protein tyrosine kinase function, the method comprising:

(a) providing a three dimensional representation of a compound, ligand, or ligand analog complexed with a receptor protein tyrosine kinase, wherein the three dimensional representations ofthe compounds, ligands, or ligand analogs and the receptor protein tyrosine kinase are defined by atomic structural coordinates;

(b) identifying the compound, ligand, or ligand analog as a potential modulator by replacing portions ofthe compound, ligand, or ligand analog complexed with the receptor protein tyrosine kinase with similar chemical structures from a data base using a compound construction computer program, wherein the representations ofthe compounds are defined by structural coordinates;

(c) administering the potenial modulator to cells; (d) comparing the level of cell growth between cells not administered the potential modulator and cells administered the potential modulator; and

(e) identifying the potential modulator as a modulator of receptor protein tyrosine kinase function based on the difference in cell growth.

66. A modulator of receptor protein tyrosine kinase function identified by the method of any one of claims 58-65.

67. A method of diagnosing a disease by identifying cells harboring a receptor protein tyrosine kinase with inappropriate activity, the method comprising:

(a) administering a modulator of receptor protein tyrosine kinase function to cells;

(b) comparing a rate of cell growth by cells not administered the modulator and a rate of cell growth by cells administered the modulator; and

(c) diagnosing a disease by characterizing cells harboring a receptor protein tyrosine kinase with inappropriate activity by identifying those cells administered the modulator that exhibit a rate of cell growth different from the rate of cell growth by cells not administered the modulator.

68. A method of treating a disease associated with a receptor protein tyrosine kinase with inappropriate activity in a cellular organism, the method comprising:

(a) administering a modulator of receptor protein tyrosine kinase function to the organism, where the modulator is in an acceptable pharmaceutical preparation; and

(b) activating or inhibiting the receptor protein tyrosine kinase function to treat the disease.

69. A crystal comprising a polypeptide, which includes an extracellular domain of a receptor protein tyrosine kinase; and a ligand bound to the extracellular domain.

70. The crystal of claim 69 further comprising a sulfated oligosaccharide bound to at least one ofthe ligand bound and the receptor protein tyrosine kinase.

71. The crystal of claim 70 wherein the sulfated oligosaccharide is a sulfated disaccharide, hexasaccharide, octasaccharide, decasaccharide, or dodecasaccharide.

72. The crystal of claim 70 wherein the sulfated oligosaccharide is sulfated mucooligosaccharide.

73. The crystal of claim 72 wherein the sulfated mucooligosaccharide is heparin.

74. The crystal of claim 70 comprising a FGF:FGFR:heparin ternary complex.

75. The crystal of claim 74 wherein the FGF:FGFR:heparin ternary complex is a FGF2:FGFR1 :heparin ternary complex.

76. The crystal of claim 69 wherein the receptor protein tyrosine kinase is a fibroblast growth factor receptor and the ligand is a fibroblast growth factor.

77. The crystal of claim 76 wherein the receptor protein tyrosine kinase is fibroblast growth factor receptor 1 and the ligand is FGF2.

78. A three-dimensional representation ofthe structure ofthe polypeptide of claim 1, 8, 69, 70 or 73.

79. The three-dimensional representation of claim 78 in computer readable form.

80. A computer-readable medium having recorded thereon x-ray coordinate data for a crystal comprising a polypeptide which includes an extracellular domain of a receptor protein tyrosine kinase.

81. The computer-readable medium of claim 80, wherein the x-ray coordinate data is set forth in Table 1, 2, 3 or 6.

82. The computer-readable medium of claim 80, wherein the medium is selected from the group consisting of RAM, ROM, magnetic media, optical media, magnetic-optical media, floppy disks, hard disks, mini-disks, servers, CD, and DVD.

83. The computer-readable medium of claim 80, wherein when said medium is read by a machine programmed with instructions for using the data, the machine is capable of generating signals for analyzing molecular interaction.

84. The computer-readable medium of claim 83, wherein the signals are image signals that can depict a three-dimensional representation ofthe polypeptide or a portion thereof.

85. The computer-readable medium of claim 83, wherein the receptor protein tyrosine kinase is a fibroblast growth factor receptor; the crystal further comprises a fibroblast growth factor or portion thereof bound to the extracellular domain ofthe fibroblast growth factor receptor; and the image signals can depict a three-dimensional representation of a structure which includes an interface between the fibroblast growth factor receptor and the fibroblast growth factor.

86. The computer-readable medium of claim 87, further comprising a sulfated mucosaccharide bound to at least one ofthe fibroblast growth factor and the fibroblast growth factor receptor.

87. A computer-readable medium having recorded thereon x-ray coordinate data for a crystal comprising a polypeptide which includes a receptor binding core of a stem cell factor.

88. The computer-readable medium of claim 87, wherein the x-ray coordinate data is set forth in Table 4.

89. The computer-readable medium of claim 87, wherein the crystal further comprises a c-kit or portion thereof bound to the receptor binding core ofthe stem cell factor.