EP1187563B1 - Instrument medical de traitement de tissu biologique et procede de transmission d'ondes de pression - Google Patents
Instrument medical de traitement de tissu biologique et procede de transmission d'ondes de pression Download PDFInfo
- Publication number
- EP1187563B1 EP1187563B1 EP00941984A EP00941984A EP1187563B1 EP 1187563 B1 EP1187563 B1 EP 1187563B1 EP 00941984 A EP00941984 A EP 00941984A EP 00941984 A EP00941984 A EP 00941984A EP 1187563 B1 EP1187563 B1 EP 1187563B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- pressure
- pressure chamber
- membrane
- biological tissue
- instrument according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/225—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
-
- G—PHYSICS
- G10—MUSICAL INSTRUMENTS; ACOUSTICS
- G10K—SOUND-PRODUCING DEVICES; METHODS OR DEVICES FOR PROTECTING AGAINST, OR FOR DAMPING, NOISE OR OTHER ACOUSTIC WAVES IN GENERAL; ACOUSTICS NOT OTHERWISE PROVIDED FOR
- G10K11/00—Methods or devices for transmitting, conducting or directing sound in general; Methods or devices for protecting against, or for damping, noise or other acoustic waves in general
- G10K11/18—Methods or devices for transmitting, conducting or directing sound
- G10K11/22—Methods or devices for transmitting, conducting or directing sound for conducting sound through hollow pipes, e.g. speaking tubes
-
- G—PHYSICS
- G10—MUSICAL INSTRUMENTS; ACOUSTICS
- G10K—SOUND-PRODUCING DEVICES; METHODS OR DEVICES FOR PROTECTING AGAINST, OR FOR DAMPING, NOISE OR OTHER ACOUSTIC WAVES IN GENERAL; ACOUSTICS NOT OTHERWISE PROVIDED FOR
- G10K11/00—Methods or devices for transmitting, conducting or directing sound in general; Methods or devices for protecting against, or for damping, noise or other acoustic waves in general
- G10K11/18—Methods or devices for transmitting, conducting or directing sound
- G10K11/24—Methods or devices for transmitting, conducting or directing sound for conducting sound through solid bodies, e.g. wires
Definitions
- the invention relates to a medical instrument for treatment of biological tissue by means of unfocused pressure waves.
- Such instruments serve by means of pressure or shock waves the healing process of bone fractures and bone defects but also to accelerate in the periodontal disease or at all to get started first. Another application is the treatment pain in tendon attachments.
- extracorporeal Pressure wave devices will be the focal point of an acoustic Reflectors, e.g. by means of a spark discharge, as in the German Offenlegungsschrift DE 23 51 247 A, a pulsed pressure or shock wave generated by the Reflector is focused on the object to be irradiated. It It is assumed that with the help of the pressure waves micro damages be generated in the biological tissue, which the body to regeneration measures cause.
- Such known pressure wave devices have a closely localized Focus area in which alone has a therapeutic effect is observed. This is due to the fact that these pressure wave devices - so-called extracorporeal lithotriptors - for the Smash of body stones were developed. At this Applying all the energy in a small area, in In this case, on the body stone to be destroyed, bundled. For a satisfactory treatment result for bone fractures and In pain therapy, however, usually a larger area be evenly sonicated. This requires a complex Movement mechanism and is also by repeated visits the treatment position very time-consuming.
- German patent application DE 197 25 477 A1 is a Device in which unfocused with a transmission element, mechanically generated pressure waves in biological tissue be coupled. The user must be blunt Direct the transfer element to the treatment site. This very much However, simply constructed instrument has the consequence that the Movement of the transmission element - even if they are only on a change in length limited by the influence of a pressure wave - is unavoidable. For applications where a such device is applied to the skin surface like the Load by the deflection of the transmission element, such as Redness and slight swelling, justifiable. In the treatment a periodontal disease, on the other hand, would require such an instrument be placed on the gum, which this burden not withstand.
- Document WO-A-94/17771 discloses a medical instrument having a pressure wave generating means and a pressure chamber that transfers pressure waves and couples them into biological tissue, wherein the pressure chamber consists of an elongated, liquid-filled channel, and wherein a linearly reciprocable impact part couples pressure waves into the fluid of the pressure chamber.
- the invention is therefore based on the object, a medical Instrument for the transmission of Pressure waves form so that it is a simple and inexpensive Way a uniform energy distribution of Allows pressure wave on a large area of effect, without in the transmission of the pressure wave from the instrument the biological tissue to harm the same.
- the invention provides that the transmission device has a liquid-filled pressure chamber, their liquid coupled. Pressure waves on one the output side end of the pressure chamber arranged membrane which transmits the pressure waves transmitted by the fluid incoupled into the biological tissue.
- the impedance of the fluid is largely the impedance of the corresponds biological tissue into which the pressure wave coupled is to be created during transmission of the pressure wave from the fluid across the membrane to the biological Tissue no transmission losses.
- a uniform energy distribution of the pressure wave over a large area Impact range are possible without the biological Damage tissue during transmission of the pressure wave.
- a thin membrane is used as a coupling device. This closes on the one hand the pressure chamber at its output side End and is on the other hand in the coupling of the Pressure waves from the liquid into the biological tissue not hindrance. Also, the entrance surface of the biological tissue during the transmission of the pressure wave through the membrane mechanically not loaded, so that the use of the instrument is possible for all types of biological tissue.
- a membrane impedance matched plastic films can be used as a membrane impedance matched plastic films.
- the pressure chamber consists of an elongated Channel.
- the channel shape has the advantage that the of the pressure wave generating device coupled pressure wave not sideways can emigrate and in this way over a longer distance be transported as a plane wave without major losses can.
- the ratio of the length of the pressure chamber to its diameter is preferably in the range between 2 and 10.
- the pressure wave generating device can within the pressure chamber be arranged.
- the pressure wave generating device generates a non-directional pressure wave, which is spherical spreads and their energy accordingly with the distance rapidly decreasing from its place of origin. Lying emergence and Place of application not close to each other, so only a small one achieves Part of the energy used its destination. Around To limit these losses can be filled with liquid Pressure chamber be designed so that the pressure wave generating device within the tubular channel nearby its input-side end is arranged.
- the pressure wave generating device the pressure waves mechanically coupled into the pressure chamber and that a linear guided, in Axial direction elastically mounted transmission element with a Exit interface coupled to the liquid of the pressure chamber is and mechanically induced pressure waves on the Fluid transfers.
- the transmission element is from a subjected to linear reciprocating impact part due to of the power surge mechanically induces a pressure wave, the to the exit interface of the membrane or the transmission element propagates.
- the impact part is guided coaxially to the transmission element.
- the pressure wave generating device generates the coupled Pressure waves periodically.
- a larger number of consecutive single pulsed pressure waves with weaker ones Energy shows a better healing success in the biological Tissue as a single strong pressure pulse.
- the pressure wave generating device can therefore with a refresh rate individual pressure pulses between 1 and 20 Hz work, with the Treatment of the biological tissue about 1000 to 2000 pressure pulses required are.
- the driving means for continuous operation preferably designed such that a periodic movement of the drive is possible. If, for example, a pneumatic Impact part used by his serve on a transmission element in this generates a pressure wave, so the air flows can be designed so that the impact part a performs continuous floatation and periodically the transmission element meets.
- Electrically operated pressure wave generating devices usually powered by a capacitor bank.
- the power supply for charging the batteries are sufficiently high, so the predetermined number delivered by pressure pulses with the necessary repetition frequency can be.
- the cross section of the channel towards the outer Membrane is conically dilated or tapered.
- One in the direction the membrane tapering pressure chamber amplifies the pressure wave by the reduction of their cross-section.
- An extension the pressure chamber weakens the pressure wave, but sonicates a larger treatment area.
- an impedance-adapting medium may be arranged between the outer membrane and the biological tissue, the coupling the pressure waves in the biological tissue improved. Is the membrane not absolutely level and without air pockets on the biological tissue, so becomes part of the pressure pulse reflected in this acoustic discontinuity and the Reduced share of coupling pressure waves.
- paste-shaped impedance matching medium is one Ultrasound gel or other paste-like masses with a similar Impedance like biological tissue, such as Vaseline.
- the handpiece 1 shown in Fig. 1 consists of a housing. 2 a mechanical pressure wave generating device 4 with a Inner cylinder 7, in which an impact member 40 by means of pneumatic Drive means 44 in conjunction with a dynamic pressure chamber 48, which surrounds the inner cylinder 7 coaxially annular, between two end positions is moved back and forth.
- a transmission device 8 for pressure waves screwed.
- the impact part 40 hydraulically, mechanically, electromagnetically or by other drive means to move.
- the length of the acceleration path to be selected.
- the impact part 40 at the end of the inner cylinder 7 is a magnet holder 50 is arranged, which is the metallic impact part 40 can hold in its proximal end position until again an applied via the terminal 52 pneumatic pressure the Impact part 40 in the direction of the distal end of the inner cylinder 7 accelerates.
- the transmission element 30 consists of a in Essential cylindrical metallic probe with a plan or slightly inward or outward arched exit interface 32.
- the transmission element 30 is in a hollow cylindrical Receiving part 34 slidably guided.
- a ring collar 35 am Transmission element 30 serves as a stop member against the receiving part 34, wherein between annular collar 35 and the receiving part 34th a spring / damping element 38 is arranged, which is the transmission element 30 decoupled from the receiving part 34 and also for it ensures that the transfer element 30 after the impact back to its original position at the distal end of the inner cylinder 7 returns.
- a transmission element 30th Slidably receiving O-ring 37 seals the pressure wave generating device 4 against the transmission device 8 for the Pressure waves off.
- the exit interface 32 of the transfer element 30 is in direct contact with a fluid filled pressure chamber 12 of the transfer device 8.
- a fluid filled pressure chamber 12 of the transfer device 8 As the liquid is preferred a the acoustic properties of biological tissue similar substance, e.g. Water.
- the pressure chamber 12 may have an elongated cylindrical shape about the pressure wave but it can also be kept very short, when the pressure wave generating means 4 pressure waves sufficient Intensity generated.
- the pressure chamber 12 is at the distal End of a membrane 16 closed.
- a tensioning device 20 biases the membrane 16 over the distal end of the Pressure chamber 12 and closes the output side end tight against the environment, so that the liquid 14 is not out of the Pressure chamber 3 can emerge.
- the impact member 40 is defined by the in the dynamic pressure chamber 48 built over pressure and the backflow the air from the dynamic pressure chamber 48 through the annular slots 54 through to its rest position at the proximal end the inner cylinder 7 and returned by the magnet holder 50th held.
- the instrument is now back to a new one Beating ready.
- Fig. 2 shows a device with a spark discharge gap for generating pressure waves.
- An electrical circuit 19 supplies the two electrodes 21 of an electro-hydraulic Probe 18 with a short voltage pulse. Is the surrounding Liquid 14 in the pressure chamber 12 is electrically conductive, This leads to a sparkover between the electrodes 21. Due to the associated sudden plasma formation creates a pressure wave, which is in the pressure chamber 12th spreads and over the membrane 16 in the with the membrane 16 in Contact standing biological tissue is docked.
- FIG. 3 Another device with a pressure wave generating device 3 is shown in FIG. 3 shown.
- An electrical circuit 23 provides a Voltage pulse to a arranged in the pressure chamber 12 piezoelectric Element 22. As a result of the voltage pulse stretches the piezoelectric element 22 from and generates in the surrounding liquid 14 a pressure wave.
- Fig. 4 shows another device with a pressure wave generating device 4 with a coil assembly 24, which is an electrical Circuit 25 is powered. Distal in front of the coil arrangement 24, an exciter membrane 26 is arranged. The coil arrangement 24 induces an eddy current in the exciter membrane 26, which in turn builds up a magnetic field. By the repulsive Forces between the coil assembly 24 and the exciter membrane 26 will be the latter with a short current pulse the electrical circuit 25 jerky from the electrical Coil assembly 24 moves away, creating a pressure wave in the Pressure chamber 12 is coupled.
- the transmission devices 8 of the different embodiments differ in length and shape the pressure chamber 12.
- Fig. 5 shows a transmission device 8, in which the pressure chamber 12 in the distal direction conical rejuvenated.
- One generated by a pressure wave generating device 4 Pressure wave is due to the reduction of the effective Cross-section of the pressure chamber 12 reinforced.
- the extended Pressure chamber 12 as shown in Fig. 6, so the pressure wave attenuated, but sonicates a larger area. Is a Splitting the pressure wave is not required or not desired so the pressure chamber 12 may be kept short, as in the embodiments of FIGS. 2 to 4.
- the transmission device 8 is designed as a screw head and can be screwed onto the pressure wave generating device 4 become.
- a seal 10 seals the transmission device 8 against the receiving part 34 of the pressure wave transmission device 4 off.
- the pressure chamber 12 can be up to the receiving part 34 extend into it.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Multimedia (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Mechanical Engineering (AREA)
- Surgical Instruments (AREA)
- Materials For Medical Uses (AREA)
Claims (11)
- Instrument à usage médical pour le traitement de tissu biologique, lequel instrument comporte un boítier (2), un dispositif de génération d'ondes de pression (4) et un dispositif de transmission (8) pour l'injection des ondes de pression non focalisées dans le corps d'êtres vivants,
le dispositif de transmission (8) comportant une chambre de pression (12) qui présente une extrémité d'entrée et une extrémité de sortie et qui contient un liquide (14) dans lequel des ondes de pression provenant du dispositif de génération d'ondes de pression (4) peuvent être injectées et transmises au tissu biologique à l'extrémité de sortie de la chambre de pression (12), les ondes de pression transmises par le liquide pouvant être injectées de façon non focalisée dans le tissu,
une membrane (16) étant placée à l'extrémité de sortie de la chambre de pression (12),
la chambre de pression (12) se composant d'un canal dans lequel un élément de transmission (30), guidé linéairement dans une direction axiale, est monté élastiquement,
l'élément de transmission (30) étant couplé par une surface limite de sortie (32) au liquide (14) de la chambre de pression (12), et
l'élément de transmission (30) étant sollicité par une pièce de percussion (40) qui est mobile linéairement suivant un mouvement alternatif et qui induit mécaniquement une onde de pression à la suite d'une impulsion. - Instrument selon la revendication 1, dans lequel le rapport entre la longueur et le diamètre de la chambre de pression (12) en forme de canal est de l'ordre de 2 à 10.
- Instrument selon la revendication 1 ou 2, dans lequel la pièce de percussion (40) est guidée coaxialement à l'élément de transmission (30).
- Instrument selon l'une des revendications 1 à 3, dans lequel le dispositif de génération d'ondes de pression (4) génère les ondes de pression périodiquement.
- Instrument selon l'une des revendications 1 à 4, dans lequel la section de la chambre de pression (12) est élargie en cône du côté distal par rapport à la membrane (16).
- Instrument selon l'une des revendications 1 à 4, dans lequel la section de la chambre de pression (12) s'amincit en cône du côté distal par rapport à la membrane (16).
- Instrument selon l'une des revendications 1 à 6, dans lequel la membrane (16) est fixée de façon amovible au dispositif de transmission (8).
- Instrument selon l'une des revendications 1 à 7, dans lequel un dispositif de serrage (20) maintient la membrane (16) en exerçant une précontrainte.
- Instrument selon l'une des revendications 1 à 8, dans lequel la membrane (16) est constituée d'une feuille de matière plastique adaptée en impédance à la densité d'un fluide.
- Instrument selon l'une des revendications 1 à 9, dans lequel le liquide (14) contenu dans la chambre de pression (12) est une solution saline.
- Instrument selon l'une des revendications 1 à 10, dans lequel une substance d'adaptation d'impédance, qui améliore l'injection des ondes de pression dans le tissu biologique, est placée entre la membrane (16) et le tissu biologique.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE20023753U DE20023753U1 (de) | 1999-06-24 | 2000-05-25 | Medizinisches Instrument zur Behandlung von biologischem Gewebe |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19929112A DE19929112A1 (de) | 1999-06-24 | 1999-06-24 | Medizinisches Instrument zur Behandlung von biologischem Gewebe sowie Verfahren zum Übertragen von Druckwellen |
DE19929112 | 1999-06-24 | ||
PCT/EP2000/004771 WO2001000094A1 (fr) | 1999-06-24 | 2000-05-25 | Instrument medical de traitement de tissu biologique et procede de transmission d'ondes de pression |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1187563A1 EP1187563A1 (fr) | 2002-03-20 |
EP1187563B1 true EP1187563B1 (fr) | 2005-11-30 |
Family
ID=7912495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00941984A Expired - Lifetime EP1187563B1 (fr) | 1999-06-24 | 2000-05-25 | Instrument medical de traitement de tissu biologique et procede de transmission d'ondes de pression |
Country Status (6)
Country | Link |
---|---|
US (1) | US6736784B1 (fr) |
EP (1) | EP1187563B1 (fr) |
AT (1) | ATE311150T1 (fr) |
DE (2) | DE19929112A1 (fr) |
ES (1) | ES2253234T3 (fr) |
WO (1) | WO2001000094A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023079126A1 (fr) * | 2021-11-08 | 2023-05-11 | Toposens Gmbh | Dispositif transducteur acoustique |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19929112A1 (de) * | 1999-06-24 | 2001-01-11 | Ferton Holding Sa | Medizinisches Instrument zur Behandlung von biologischem Gewebe sowie Verfahren zum Übertragen von Druckwellen |
IL141123A0 (en) * | 2001-01-26 | 2002-02-10 | Iger Yoni | Method and apparatus for the delivery of substances to biological components |
DE10130639A1 (de) | 2001-06-26 | 2003-01-30 | Hmt Ag | Verfahren und Vorrichtung zum Erzeugen von Stoßwellen für medizinische Anwendungen |
DE10215416B4 (de) * | 2002-04-08 | 2020-10-29 | Ferton Holding S.A. | Medizinisches Gerät zur Behandlung von biologischem Gewebe |
US20040092819A1 (en) * | 2002-08-16 | 2004-05-13 | Hmt High Medical Technologies Ag | Method for treating laminitis in horses, ponies and other equines with acoustic waves |
US20040162582A1 (en) * | 2003-02-13 | 2004-08-19 | Hmt High Medical Technologies Ag | Treatment of osteoarthritis |
US20040162508A1 (en) * | 2003-02-19 | 2004-08-19 | Walter Uebelacker | Shock wave therapy method and device |
US8257282B2 (en) * | 2004-02-19 | 2012-09-04 | General Patent, Llc | Pressure pulse/shock wave apparatus for generating waves having plane, nearly plane, convergent off target or divergent characteristics |
DE10331694A1 (de) * | 2003-07-11 | 2005-02-10 | Karl Storz Gmbh & Co. Kg | Vorrichtung zum Fragmentieren von Substanzen |
DE602004007758T2 (de) * | 2004-03-10 | 2008-04-30 | Elettronica Pagani S.R.L. | Instrument zur medizinischen Behandlung von Gewebe mittels Schockwellen |
DE102004046848A1 (de) * | 2004-09-27 | 2006-04-06 | Ferton Holding S.A. | Vorrichtung und Verfahren zur Entfernung von Zahnapplikationen wie Brackets |
US7578796B2 (en) * | 2004-10-22 | 2009-08-25 | General Patent Llc | Method of shockwave treating fish and shellfish |
US7857775B2 (en) * | 2005-03-15 | 2010-12-28 | Syneron Medical Ltd. | Method for soft tissue treatment |
AT8346U1 (de) | 2005-04-29 | 2006-06-15 | Ceratitzit Austria Ges M B H | Beschichtetes werkzeug |
WO2007108854A2 (fr) * | 2005-12-30 | 2007-09-27 | Sanuwave, Inc. | Système applicateur d'ondes de pression acoustique à compresse de conduction |
DE102006062356B3 (de) * | 2006-12-22 | 2008-04-24 | Storz Medical Ag | Medizinisches Gerät zur Behandlung des menschlichen oder tierischen Körpers mit mechanischen Druck- oder Stoßwellen |
US9232959B2 (en) | 2007-01-02 | 2016-01-12 | Aquabeam, Llc | Multi fluid tissue resection methods and devices |
US8814921B2 (en) | 2008-03-06 | 2014-08-26 | Aquabeam Llc | Tissue ablation and cautery with optical energy carried in fluid stream |
DE202007007922U1 (de) * | 2007-05-31 | 2008-10-09 | Storz Medical Ag | Medizinisches Gerät zur Behandlung des menschlichen oder tierischen Körpers mit mechanischen Druck- oder Stoßwellen |
US20100036294A1 (en) | 2008-05-07 | 2010-02-11 | Robert Mantell | Radially-Firing Electrohydraulic Lithotripsy Probe |
US10702293B2 (en) | 2008-06-13 | 2020-07-07 | Shockwave Medical, Inc. | Two-stage method for treating calcified lesions within the wall of a blood vessel |
AU2009257368B2 (en) | 2008-06-13 | 2014-09-11 | Djt, Llc | Shockwave balloon catheter system |
US9072534B2 (en) | 2008-06-13 | 2015-07-07 | Shockwave Medical, Inc. | Non-cavitation shockwave balloon catheter system |
US20100022943A1 (en) * | 2008-07-25 | 2010-01-28 | Medtronic Vascular, Inc. | Hydrodynamic Thrombectomy Catheter |
US20100023033A1 (en) * | 2008-07-25 | 2010-01-28 | Medtronic Vescular, Inc. | Hydrodynamic Thrombectomy Catheter |
EP3960237B1 (fr) * | 2008-10-31 | 2023-12-13 | Ferton Holding SA | Instrument de traitement des tissus biologiques par ondes de pression de type ondes de choc |
US9180280B2 (en) * | 2008-11-04 | 2015-11-10 | Shockwave Medical, Inc. | Drug delivery shockwave balloon catheter system |
US9044618B2 (en) | 2008-11-05 | 2015-06-02 | Shockwave Medical, Inc. | Shockwave valvuloplasty catheter system |
PT2564338T (pt) * | 2010-04-28 | 2021-05-14 | Empi Corp | Sistemas e métodos para modulação de terapia por onda de pressão |
US8574247B2 (en) | 2011-11-08 | 2013-11-05 | Shockwave Medical, Inc. | Shock wave valvuloplasty device with moveable shock wave generator |
US9504604B2 (en) | 2011-12-16 | 2016-11-29 | Auris Surgical Robotics, Inc. | Lithotripsy eye treatment |
US9498236B2 (en) * | 2012-01-31 | 2016-11-22 | Hi Impacts Ltd | High pressure ballistic extracorporeal shockwave device, system and method of use |
JP6080872B2 (ja) | 2012-02-29 | 2017-02-15 | プロセプト バイオロボティクス コーポレイション | 自動化された画像誘導組織切除および治療 |
US10383765B2 (en) | 2012-04-24 | 2019-08-20 | Auris Health, Inc. | Apparatus and method for a global coordinate system for use in robotic surgery |
US9642673B2 (en) | 2012-06-27 | 2017-05-09 | Shockwave Medical, Inc. | Shock wave balloon catheter with multiple shock wave sources |
JP6257625B2 (ja) | 2012-08-06 | 2018-01-10 | ショックウェーブ メディカル, インコーポレイテッド | 血管形成術用衝撃波カテーテルのための薄型電極 |
US9220521B2 (en) | 2012-08-06 | 2015-12-29 | Shockwave Medical, Inc. | Shockwave catheter |
WO2014025981A1 (fr) | 2012-08-08 | 2014-02-13 | Shockwave Medical, Inc. | Valvuloplastie à ondes de choc ayant de multiples ballonnets |
US9138249B2 (en) | 2012-08-17 | 2015-09-22 | Shockwave Medical, Inc. | Shock wave catheter system with arc preconditioning |
US9522012B2 (en) | 2012-09-13 | 2016-12-20 | Shockwave Medical, Inc. | Shockwave catheter system with energy control |
US9333000B2 (en) | 2012-09-13 | 2016-05-10 | Shockwave Medical, Inc. | Shockwave catheter system with energy control |
US10231867B2 (en) | 2013-01-18 | 2019-03-19 | Auris Health, Inc. | Method, apparatus and system for a water jet |
US9867635B2 (en) | 2013-03-08 | 2018-01-16 | Auris Surgical Robotics, Inc. | Method, apparatus and system for a water jet |
US10149720B2 (en) | 2013-03-08 | 2018-12-11 | Auris Health, Inc. | Method, apparatus, and a system for facilitating bending of an instrument in a surgical or medical robotic environment |
US10080576B2 (en) | 2013-03-08 | 2018-09-25 | Auris Health, Inc. | Method, apparatus, and a system for facilitating bending of an instrument in a surgical or medical robotic environment |
CA2905107C (fr) | 2013-03-11 | 2020-04-14 | Northgate Technologies Inc. | Lithotriteur electrohydraulique non focalise |
US10744035B2 (en) | 2013-06-11 | 2020-08-18 | Auris Health, Inc. | Methods for robotic assisted cataract surgery |
US10426661B2 (en) | 2013-08-13 | 2019-10-01 | Auris Health, Inc. | Method and apparatus for laser assisted cataract surgery |
US9737373B2 (en) | 2013-10-24 | 2017-08-22 | Auris Surgical Robotics, Inc. | Instrument device manipulator and surgical drape |
US9763741B2 (en) | 2013-10-24 | 2017-09-19 | Auris Surgical Robotics, Inc. | System for robotic-assisted endolumenal surgery and related methods |
US9730715B2 (en) | 2014-05-08 | 2017-08-15 | Shockwave Medical, Inc. | Shock wave guide wire |
US10792464B2 (en) | 2014-07-01 | 2020-10-06 | Auris Health, Inc. | Tool and method for using surgical endoscope with spiral lumens |
US9788910B2 (en) | 2014-07-01 | 2017-10-17 | Auris Surgical Robotics, Inc. | Instrument-mounted tension sensing mechanism for robotically-driven medical instruments |
JP6938507B2 (ja) | 2015-09-09 | 2021-09-22 | オーリス ヘルス インコーポレイテッド | 手術支援ロボットシステム用の器械装置マニピュレータ |
US11484724B2 (en) | 2015-09-30 | 2022-11-01 | Btl Medical Solutions A.S. | Methods and devices for tissue treatment using mechanical stimulation and electromagnetic field |
US10018113B2 (en) * | 2015-11-11 | 2018-07-10 | General Electric Company | Ultrasonic cleaning system and method |
WO2017087195A1 (fr) | 2015-11-18 | 2017-05-26 | Shockwave Medical, Inc. | Électrodes d'onde de choc |
US10226265B2 (en) | 2016-04-25 | 2019-03-12 | Shockwave Medical, Inc. | Shock wave device with polarity switching |
EP3522797B8 (fr) | 2016-10-06 | 2021-01-13 | Shockwave Medical, Inc. | Réparation de feuillet aortique à l'aide d'applicateurs d'ondes de choc |
US10357264B2 (en) | 2016-12-06 | 2019-07-23 | Shockwave Medical, Inc. | Shock wave balloon catheter with insertable electrodes |
US10441300B2 (en) | 2017-04-19 | 2019-10-15 | Shockwave Medical, Inc. | Drug delivery shock wave balloon catheter system |
US11020135B1 (en) | 2017-04-25 | 2021-06-01 | Shockwave Medical, Inc. | Shock wave device for treating vascular plaques |
US10966737B2 (en) | 2017-06-19 | 2021-04-06 | Shockwave Medical, Inc. | Device and method for generating forward directed shock waves |
US10709462B2 (en) | 2017-11-17 | 2020-07-14 | Shockwave Medical, Inc. | Low profile electrodes for a shock wave catheter |
US11864782B2 (en) | 2017-11-30 | 2024-01-09 | BTL Medical Solutions A. S. | Shock wave device |
ES2948245T3 (es) | 2018-06-21 | 2023-09-06 | Shockwave Medical Inc | Sistema para el tratamiento de oclusiones en luces corporales |
CN114727828A (zh) | 2019-09-24 | 2022-07-08 | 冲击波医疗公司 | 用于治疗体腔血栓的系统 |
US11992232B2 (en) | 2020-10-27 | 2024-05-28 | Shockwave Medical, Inc. | System for treating thrombus in body lumens |
CN112438775B (zh) * | 2020-11-23 | 2021-09-14 | 安庆市立医院 | 一种泌尿外科尿路结石碎石装置 |
US12023098B2 (en) | 2021-10-05 | 2024-07-02 | Shockwave Medical, Inc. | Lesion crossing shock wave catheter |
US12035932B1 (en) | 2023-04-21 | 2024-07-16 | Shockwave Medical, Inc. | Intravascular lithotripsy catheter with slotted emitter bands |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3970076A (en) * | 1974-04-18 | 1976-07-20 | Dornier System Gmbh | Apparatus for heart stimulation |
DE3038445A1 (de) * | 1980-10-11 | 1982-05-27 | Dornier Gmbh, 7990 Friedrichshafen | Stosswellengenerator fuer medizinische anwendungsfaelle |
DE3220751A1 (de) * | 1982-06-02 | 1983-12-08 | Jörg Dr. 8022 Grünwald Schüller | Vorrichtung zur zertruemmerung von konkrementen, insbesondere von nierensteinen, im lebenden menschlichen oder tierischen koerper |
US4603701A (en) * | 1983-12-16 | 1986-08-05 | Hewlett-Packard Company | Stand-off device with special fluid |
DE3502751A1 (de) * | 1985-01-28 | 1986-07-31 | Siemens AG, 1000 Berlin und 8000 München | Stosswellenrohr mit einer langen lebensdauer |
FR2584148B1 (fr) * | 1985-06-28 | 1989-05-05 | Dory Jacques | Generateur d'impulsions elastiques de grande puissance focalisees dans un liquide et obtenues par percussion |
DE3812837A1 (de) * | 1988-04-18 | 1989-11-02 | Schubert Werner | Bauelement fuer extracorporales einbringen von stosswellen |
US5273027A (en) * | 1990-03-27 | 1993-12-28 | Olympus Optical Co., Ltd. | Method for dissolving a thickened mass within a living body and dissolving therapeutic apparatus for same |
US5727556A (en) * | 1993-02-10 | 1998-03-17 | Weth; Gosbert | Method for pain therapy and/or for influencing the vegetative nervous system |
US5493303A (en) | 1994-07-12 | 1996-02-20 | M/A-Com, Inc. | Monopulse transceiver |
US5626554A (en) * | 1995-02-21 | 1997-05-06 | Exogen, Inc. | Gel containment structure |
SE504146C2 (sv) * | 1995-03-16 | 1996-11-18 | Lars Ekberg | Ultraljudsond |
US5494038A (en) * | 1995-04-25 | 1996-02-27 | Abbott Laboratories | Apparatus for ultrasound testing |
DE19532219C2 (de) * | 1995-09-01 | 1997-07-31 | Tzn Forschung & Entwicklung | Energiewandler zur Hochleistungspulserzeugung |
DE19618972C2 (de) * | 1996-05-10 | 2000-06-15 | Ferton Holding Delemont | Handgerät zur Verwendung bei der Lithotripsie |
GB9617749D0 (en) * | 1996-08-23 | 1996-10-02 | Young Michael J R | Improved apparatus for ultrasonic therapeutic trteatment |
IL120079A (en) * | 1997-01-27 | 2001-03-19 | Technion Res & Dev Foundation | Ultrasound system and cosmetic methods utilizing same |
DE19725477C2 (de) * | 1997-06-17 | 1999-10-21 | Ferton Holding | Medizinisches Instrument zur Behandlung von biologischem Gewebe |
DE19929112A1 (de) * | 1999-06-24 | 2001-01-11 | Ferton Holding Sa | Medizinisches Instrument zur Behandlung von biologischem Gewebe sowie Verfahren zum Übertragen von Druckwellen |
-
1999
- 1999-06-24 DE DE19929112A patent/DE19929112A1/de not_active Ceased
-
2000
- 2000-05-25 DE DE50011757T patent/DE50011757D1/de not_active Expired - Lifetime
- 2000-05-25 AT AT00941984T patent/ATE311150T1/de not_active IP Right Cessation
- 2000-05-25 US US10/018,805 patent/US6736784B1/en not_active Expired - Lifetime
- 2000-05-25 WO PCT/EP2000/004771 patent/WO2001000094A1/fr active IP Right Grant
- 2000-05-25 EP EP00941984A patent/EP1187563B1/fr not_active Expired - Lifetime
- 2000-05-25 ES ES00941984T patent/ES2253234T3/es not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023079126A1 (fr) * | 2021-11-08 | 2023-05-11 | Toposens Gmbh | Dispositif transducteur acoustique |
LU500838B1 (de) * | 2021-11-08 | 2023-05-15 | Toposens Gmbh | Schallwandlervorrichtung |
Also Published As
Publication number | Publication date |
---|---|
DE19929112A1 (de) | 2001-01-11 |
US6736784B1 (en) | 2004-05-18 |
EP1187563A1 (fr) | 2002-03-20 |
DE50011757D1 (de) | 2006-01-05 |
ATE311150T1 (de) | 2005-12-15 |
ES2253234T3 (es) | 2006-06-01 |
WO2001000094A1 (fr) | 2001-01-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1187563B1 (fr) | Instrument medical de traitement de tissu biologique et procede de transmission d'ondes de pression | |
EP0991447B1 (fr) | Instrument medical pour le traitement de tissus biologiques | |
EP2529792B1 (fr) | Instrument destiné au traitement de tissus biologiques par ondes de pression de type ondes de choc | |
DE3808783C2 (fr) | ||
EP1643919B1 (fr) | Dispositif de fragmentation de substances | |
DE10102317A1 (de) | Verfahren und Vorrichtung zur Beaufschlagung des Körpers eines Lebeswesens mit Druckwellen | |
EP2529678B1 (fr) | Appareil à ondes de pression pour le traitement du corps humain ou animal | |
DE19548000C1 (de) | Vorrichtung zur Ortung von Konkrementen im Körper eines Patienten | |
EP0355178A1 (fr) | Appareil pour la destruction à distance de concrétions dans le corps d'un être vivant | |
DE10215416B4 (de) | Medizinisches Gerät zur Behandlung von biologischem Gewebe | |
DE3707403C2 (de) | Medizinisches Resektionsgerät | |
EP0280088B1 (fr) | Générateur de son pour le traitement d'un être vivant avec des ondes sonores focalisées | |
DE2412690C3 (fr) | ||
DE102007013288B4 (de) | Vorrichtung zur Behandlung biologischer Körpersubstanzen mit mechanischen Druckwellen | |
DE2412690A1 (de) | Einrichtung zur zerstoerung von steinen in den harnwegen, insbesondere von harnleiter- und nierensteinen | |
DE20023753U1 (de) | Medizinisches Instrument zur Behandlung von biologischem Gewebe | |
DE102009042276A1 (de) | Vorrichtung zum Einleiten von Stosswellen in einen lebenden Körper und deren Verwendung | |
EP1502626B1 (fr) | Appareil médical pour le traitement des tissues biologiques | |
EP2347407B1 (fr) | Générateur d'ondes d'impulsions | |
EP4039202B1 (fr) | Dispositif de génération d'ondes de choc, en particulier de génération d'un champ d'action d'onde de choc comprimé | |
DE10304904A1 (de) | Ultraschall-Stosswellen-Lithotripter | |
DE2351247A1 (de) | Einrichtung zum beruehrungsfreien zertruemmern von im koerper von lebewesen befindlichen konkrementen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20011212 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20051130 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20051130 Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20051130 |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D Free format text: NOT ENGLISH Ref country code: CH Ref legal event code: EP |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D Free format text: LANGUAGE OF EP DOCUMENT: GERMAN |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: NV Representative=s name: ISLER & PEDRAZZINI AG |
|
REF | Corresponds to: |
Ref document number: 50011757 Country of ref document: DE Date of ref document: 20060105 Kind code of ref document: P |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060228 Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060228 Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060228 |
|
GBT | Gb: translation of ep patent filed (gb section 77(6)(a)/1977) |
Effective date: 20060222 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060502 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: AT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20060525 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20060531 Ref country code: MC Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20060531 |
|
NLV1 | Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents act | ||
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FG2A Ref document number: 2253234 Country of ref document: ES Kind code of ref document: T3 |
|
ET | Fr: translation filed | ||
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FD4D |
|
PLBI | Opposition filed |
Free format text: ORIGINAL CODE: 0009260 |
|
PLAX | Notice of opposition and request to file observation + time limit sent |
Free format text: ORIGINAL CODE: EPIDOSNOBS2 |
|
26 | Opposition filed |
Opponent name: STORZ MEDICAL AG Effective date: 20060830 |
|
PLAF | Information modified related to communication of a notice of opposition and request to file observations + time limit |
Free format text: ORIGINAL CODE: EPIDOSCOBS2 |
|
PLBB | Reply of patent proprietor to notice(s) of opposition received |
Free format text: ORIGINAL CODE: EPIDOSNOBS3 |
|
PLAB | Opposition data, opponent's data or that of the opponent's representative modified |
Free format text: ORIGINAL CODE: 0009299OPPO |
|
R26 | Opposition filed (corrected) |
Opponent name: STORZ MEDICAL AG Effective date: 20060830 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PCAR Free format text: ISLER & PEDRAZZINI AG;POSTFACH 1772;8027 ZUERICH (CH) |
|
PLCK | Communication despatched that opposition was rejected |
Free format text: ORIGINAL CODE: EPIDOSNREJ1 |
|
BERE | Be: lapsed |
Owner name: FERTON HOLDING SA Effective date: 20060531 |
|
APAH | Appeal reference modified |
Free format text: ORIGINAL CODE: EPIDOSCREFNO |
|
APBP | Date of receipt of notice of appeal recorded |
Free format text: ORIGINAL CODE: EPIDOSNNOA2O |
|
APBQ | Date of receipt of statement of grounds of appeal recorded |
Free format text: ORIGINAL CODE: EPIDOSNNOA3O |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20060525 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20051130 |
|
APBY | Invitation to file observations in appeal sent |
Free format text: ORIGINAL CODE: EPIDOSNOBA2O |
|
APCA | Receipt of observations in appeal recorded |
Free format text: ORIGINAL CODE: EPIDOSNOBA4O |
|
APBU | Appeal procedure closed |
Free format text: ORIGINAL CODE: EPIDOSNNOA9O |
|
APBC | Information on closure of appeal procedure deleted |
Free format text: ORIGINAL CODE: EPIDOSDNOA9O |
|
APBU | Appeal procedure closed |
Free format text: ORIGINAL CODE: EPIDOSNNOA9O |
|
PLBN | Opposition rejected |
Free format text: ORIGINAL CODE: 0009273 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: OPPOSITION REJECTED |
|
27O | Opposition rejected |
Effective date: 20111109 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R100 Ref document number: 50011757 Country of ref document: DE Effective date: 20111109 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 16 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GB Payment date: 20150521 Year of fee payment: 16 Ref country code: ES Payment date: 20150520 Year of fee payment: 16 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 20150519 Year of fee payment: 16 Ref country code: IT Payment date: 20150519 Year of fee payment: 16 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: CH Payment date: 20160526 Year of fee payment: 17 |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20160525 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160525 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: ST Effective date: 20170131 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160531 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160525 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20170529 Year of fee payment: 18 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170531 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170531 |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FD2A Effective date: 20180507 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: ES Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160526 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 50011757 Country of ref document: DE |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20181201 |