EP1185286A4 - Mu o-conopeptides and their use as local anesthetics - Google Patents

Mu o-conopeptides and their use as local anesthetics

Info

Publication number
EP1185286A4
EP1185286A4 EP00939692A EP00939692A EP1185286A4 EP 1185286 A4 EP1185286 A4 EP 1185286A4 EP 00939692 A EP00939692 A EP 00939692A EP 00939692 A EP00939692 A EP 00939692A EP 1185286 A4 EP1185286 A4 EP 1185286A4
Authority
EP
European Patent Office
Prior art keywords
conopeptides
local anesthetics
anesthetics
local
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00939692A
Other languages
German (de)
French (fr)
Other versions
EP1185286A1 (en
Inventor
Baldomero M Olivera
J Michael Mcintosh
R Tyler Mccabe
James E Garrett
Richard T Layer
John D Wagstaff
Robert M Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation UURF
Cognetix Inc
Original Assignee
University of Utah Research Foundation UURF
Cognetix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Utah Research Foundation UURF, Cognetix Inc filed Critical University of Utah Research Foundation UURF
Publication of EP1185286A1 publication Critical patent/EP1185286A1/en
Publication of EP1185286A4 publication Critical patent/EP1185286A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP00939692A 1999-06-10 2000-06-09 Mu o-conopeptides and their use as local anesthetics Withdrawn EP1185286A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13850799P 1999-06-10 1999-06-10
US138507P 1999-06-10
PCT/US2000/015779 WO2000076532A1 (en) 1999-06-10 2000-06-09 νO-CONOPEPTIDES AND THEIR USE AS LOCAL ANESTHETICS

Publications (2)

Publication Number Publication Date
EP1185286A1 EP1185286A1 (en) 2002-03-13
EP1185286A4 true EP1185286A4 (en) 2004-09-08

Family

ID=22482336

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00939692A Withdrawn EP1185286A4 (en) 1999-06-10 2000-06-09 Mu o-conopeptides and their use as local anesthetics

Country Status (5)

Country Link
EP (1) EP1185286A4 (en)
JP (1) JP2003501109A (en)
AU (1) AU5474200A (en)
CA (1) CA2376357A1 (en)
WO (1) WO2000076532A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1246635A4 (en) 1999-12-30 2004-09-01 Univ Utah Res Found O-superfamily conotoxin peptides
GB0011202D0 (en) * 2000-05-09 2000-06-28 Kci Licensing Inc Abdominal wound dressing
AU2001278963A1 (en) * 2000-07-20 2002-02-05 Cognetix, Inc. Muo-conopeptides and their use as local anesthetics
AU2001282945A1 (en) * 2000-07-21 2002-02-05 Cognetix, Inc Mu-conopeptides
CA2661014A1 (en) * 2006-08-17 2008-02-21 Eribis Pharmaceuticals Ab Cardioprotective compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719264A (en) * 1994-10-07 1998-02-17 Univ. Of Utah Research Foundation Conotoxin peptides
FR2785613A1 (en) * 1998-11-10 2000-05-12 Commissariat Energie Atomique New conotoxin, useful for treating neurodegenerative disorders, e.g. multiple sclerosis, have selective presynaptic action on neuronal sodium channels

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033206A1 (en) * 1995-04-17 1996-10-24 University Of Utah Research Foundation Conotoxin peptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719264A (en) * 1994-10-07 1998-02-17 Univ. Of Utah Research Foundation Conotoxin peptides
FR2785613A1 (en) * 1998-11-10 2000-05-12 Commissariat Energie Atomique New conotoxin, useful for treating neurodegenerative disorders, e.g. multiple sclerosis, have selective presynaptic action on neuronal sodium channels

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAI-SONG L ET AL: "CONOPEPTIDES FROM CONUS STRIATUS AND CONUS TEXTILE BY CDNA CLONING", PEPTIDES, ELMSFORD, US, vol. 20, 1999, pages 1139 - 1144, XP002939062, ISSN: 0196-9781 *
FAINZILBER M ET AL: "NEW SODIUM CHANNEL-BLOCKING CONOTOXINS ALSO AFFECT CALCIUM CURRENTSIN LYMNAEA NEURONS", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 34, no. 16, 25 April 1995 (1995-04-25), pages 5364 - 5371, XP002061899, ISSN: 0006-2960 *
See also references of WO0076532A1 *
TERLAU HEINRICH ET AL: "Mu-O-conotoxin MrVIA inhibits mammalian sodium channels, but not through site I", JOURNAL OF NEUROPHYSIOLOGY (BETHESDA), vol. 76, no. 3, 1996, pages 1423 - 1429, XP009034053, ISSN: 0022-3077 *

Also Published As

Publication number Publication date
AU5474200A (en) 2001-01-02
WO2000076532A1 (en) 2000-12-21
CA2376357A1 (en) 2000-12-21
EP1185286A1 (en) 2002-03-13
JP2003501109A (en) 2003-01-14

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Legal Events

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