EP1175228A4 - Gene therapy using tgf-beta - Google Patents
Gene therapy using tgf-betaInfo
- Publication number
- EP1175228A4 EP1175228A4 EP00925522A EP00925522A EP1175228A4 EP 1175228 A4 EP1175228 A4 EP 1175228A4 EP 00925522 A EP00925522 A EP 00925522A EP 00925522 A EP00925522 A EP 00925522A EP 1175228 A4 EP1175228 A4 EP 1175228A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- tgf
- beta
- gene therapy
- therapy
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019990015854A KR20000072904A (en) | 1999-05-03 | 1999-05-03 | An agent for treating ligament damage and repairing articular cartilage defects comprising TGF-β secreting cell |
KR9915854 | 1999-05-03 | ||
US09/345,415 US6315992B1 (en) | 1999-06-30 | 1999-06-30 | Generating cartilage in a mammal using fibroblasts transfected with a vector encoding TGF-β-1 |
US345415 | 1999-06-30 | ||
PCT/IB2000/000653 WO2000066177A1 (en) | 1999-05-03 | 2000-05-03 | GENE THERAPY USING TGF-$g(b) |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1175228A1 EP1175228A1 (en) | 2002-01-30 |
EP1175228A4 true EP1175228A4 (en) | 2003-02-26 |
Family
ID=26635050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00925522A Ceased EP1175228A4 (en) | 1999-05-03 | 2000-05-03 | Gene therapy using tgf-beta |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1175228A4 (en) |
JP (3) | JP4592186B2 (en) |
KR (1) | KR100702725B1 (en) |
CN (2) | CN1371289B (en) |
AU (1) | AU778047B2 (en) |
CA (1) | CA2373045C (en) |
WO (1) | WO2000066177A1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002243307A1 (en) * | 2000-11-08 | 2002-07-24 | Tissuegene, Inc. | Gene therapy using tgf-beta |
WO2003077852A2 (en) * | 2002-03-12 | 2003-09-25 | Tissuegene, Inc. | CARTILAGE REGENERATION USING CHONDROCYTE AND TGF-β |
US7005127B2 (en) | 2002-03-29 | 2006-02-28 | Tissuegene, Inc. | Mixed-cell gene therapy |
WO2004004663A2 (en) * | 2002-07-09 | 2004-01-15 | Stryker Corporation | Compositions and methods for ligament growth and repair |
JP2006515765A (en) * | 2002-11-15 | 2006-06-08 | エスディージーアイ・ホールディングス・インコーポレーテッド | Collagen-based materials and methods for treating synovial joints |
WO2005073365A1 (en) * | 2004-01-29 | 2005-08-11 | Japan Tissue Engineering Co., Ltd. | Method of treating cells for transplantation, cell suspension, prosthesis for transplantation and method of treating injured site |
CN105640992A (en) * | 2008-03-21 | 2016-06-08 | 组织基因公司 | Treatment of intervertebral disc degeneration |
JP5388233B2 (en) * | 2011-01-19 | 2014-01-15 | 富士ソフト株式会社 | Method for evaluating the cartilage characteristics of regenerated cartilage |
WO2013166156A2 (en) * | 2012-05-01 | 2013-11-07 | The Johns Hopkins University | Compositions and methods for treating or preventing osteoarthritis |
JP2016531147A (en) * | 2013-09-09 | 2016-10-06 | フィジーン、エルエルシーFigene, Llc | Gene therapy for chondrocyte or chondrocyte regeneration |
CN111033258B (en) * | 2017-06-30 | 2023-09-05 | 可隆生命科学株式会社 | Methods for evaluating the effectiveness of cytotherapeutic products |
CN113372432A (en) * | 2021-06-15 | 2021-09-10 | 深圳市臻质医疗科技有限公司 | Method for inducing and/or enhancing cartilage injury repair based on chemically modified mRNA coding protein factor |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5858355A (en) * | 1990-12-20 | 1999-01-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | IRAP gene as treatment for arthritis |
US6315992B1 (en) * | 1999-06-30 | 2001-11-13 | Tissuegene Co. | Generating cartilage in a mammal using fibroblasts transfected with a vector encoding TGF-β-1 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6413511B1 (en) * | 1990-12-20 | 2002-07-02 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Cartilage alterations by administering to joints chondrocytes comprising a heterologous polynucleotide |
US5869041A (en) * | 1996-01-12 | 1999-02-09 | The Miriam Hospital | Delivery of bioactive compounds to an organism |
US6077987A (en) * | 1997-09-04 | 2000-06-20 | North Shore-Long Island Jewish Research Institute | Genetic engineering of cells to enhance healing and tissue regeneration |
DE69936785D1 (en) * | 1998-05-01 | 2007-09-20 | Univ Pittsburgh | CELL-AGGRAVATED GENETIC ADMINISTRATION THROUGH THE USE OF MUSCLES DERIVED FROM MUSCLES FOR THE TREATMENT OF BONE-RELATED INJURY OR DISORDER |
-
2000
- 2000-05-03 CN CN008070741A patent/CN1371289B/en not_active Expired - Lifetime
- 2000-05-03 JP JP2000615060A patent/JP4592186B2/en not_active Expired - Lifetime
- 2000-05-03 AU AU44242/00A patent/AU778047B2/en not_active Expired
- 2000-05-03 WO PCT/IB2000/000653 patent/WO2000066177A1/en not_active Application Discontinuation
- 2000-05-03 CA CA2373045A patent/CA2373045C/en not_active Expired - Lifetime
- 2000-05-03 CN CN2010105280759A patent/CN101972275A/en active Pending
- 2000-05-03 KR KR1020017013987A patent/KR100702725B1/en active IP Right Grant
- 2000-05-03 EP EP00925522A patent/EP1175228A4/en not_active Ceased
-
2006
- 2006-07-18 JP JP2006195771A patent/JP4188986B2/en not_active Expired - Lifetime
-
2008
- 2008-07-04 JP JP2008176059A patent/JP4547446B2/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5858355A (en) * | 1990-12-20 | 1999-01-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | IRAP gene as treatment for arthritis |
US6315992B1 (en) * | 1999-06-30 | 2001-11-13 | Tissuegene Co. | Generating cartilage in a mammal using fibroblasts transfected with a vector encoding TGF-β-1 |
Non-Patent Citations (1)
Title |
---|
See also references of WO0066177A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU4424200A (en) | 2000-11-17 |
CA2373045A1 (en) | 2000-11-09 |
KR100702725B1 (en) | 2007-04-03 |
AU778047B2 (en) | 2004-11-11 |
EP1175228A1 (en) | 2002-01-30 |
JP2009019039A (en) | 2009-01-29 |
CN1371289B (en) | 2013-03-20 |
JP2002542801A (en) | 2002-12-17 |
JP4188986B2 (en) | 2008-12-03 |
JP2007008950A (en) | 2007-01-18 |
WO2000066177A1 (en) | 2000-11-09 |
JP4592186B2 (en) | 2010-12-01 |
CN1371289A (en) | 2002-09-25 |
JP4547446B2 (en) | 2010-09-22 |
KR20020036943A (en) | 2002-05-17 |
CA2373045C (en) | 2016-07-26 |
CN101972275A (en) | 2011-02-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20011130 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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AX | Request for extension of the european patent |
Free format text: AL;LT;LV;MK;RO;SI |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20030115 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7C 07K 14/495 B Ipc: 7A 61K 38/18 B Ipc: 7A 61K 48/00 A |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: TISSUEGENE, INC. |
|
17Q | First examination report despatched |
Effective date: 20040205 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
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18R | Application refused |
Effective date: 20061107 |
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REG | Reference to a national code |
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