EP1159081A1 - Device for applying a flowable medium, notably a tissue adhesive - Google Patents

Device for applying a flowable medium, notably a tissue adhesive

Info

Publication number
EP1159081A1
EP1159081A1 EP20000909342 EP00909342A EP1159081A1 EP 1159081 A1 EP1159081 A1 EP 1159081A1 EP 20000909342 EP20000909342 EP 20000909342 EP 00909342 A EP00909342 A EP 00909342A EP 1159081 A1 EP1159081 A1 EP 1159081A1
Authority
EP
European Patent Office
Prior art keywords
element
locking
member
release
chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20000909342
Other languages
German (de)
French (fr)
Inventor
Igor Denenburg
Benny Kutal
Freddy Zinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omrix Biopharmaceuticals SA
Original Assignee
Omrix Biopharmaceuticals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19910972 priority Critical
Priority to DE1999110972 priority patent/DE19910972C1/en
Application filed by Omrix Biopharmaceuticals SA filed Critical Omrix Biopharmaceuticals SA
Priority to PCT/EP2000/002017 priority patent/WO2000053339A1/en
Publication of EP1159081A1 publication Critical patent/EP1159081A1/en
Application status is Withdrawn legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491Surgical glue applicators
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05CAPPARATUS FOR APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/015Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes with pneumatically or hydraulically actuated piston or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491Surgical glue applicators
    • A61B2017/00495Surgical glue applicators for two-component glue
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05CAPPARATUS FOR APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/01Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes with manually mechanically or electrically actuated piston or the like
    • B05C17/0136Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes with manually mechanically or electrically actuated piston or the like comprising an energy storing element, e.g. a spring, for exerting, e.g. when released, pressure on the material

Abstract

The invention relates to a device for the application of a flowable medium, notably a tissue adhesive, comprising at least one reservoir (16) for the medium which presents an outlet (22) from which the medium exits when the medium and/or the reservoir (16) are subjected to pressure. A pressure-generating element (20) acts on the medium and/or the reservoir (16) and is preloaded by means of a preload device (34). Said preload device (34) can be blocked by means of a controllable blocking device (58) which presents a mobile fixing element (54) which in at least one fixing position immobilizes the preload device (34) against movements induced by preloading and for releasing said preload device (34) can be moved out of the at least one fixing position. The invention also provides for a release device (81) for the targeted releasing of the blocking device (58). The release device (81) comprises a release element (82) for temporarily displacing the fixing element (56) from its at least one fixing position.

Description

Apparatus for applying a flowable medium, in particular a

tissue adhesive

The invention relates to a device for applying flowable medium, in particular a single or multi-component tissue adhesive.

Application devices for flowable media (pasty or liquid media) are in a variety of embodiments are known (EP-B 0037393, EP-B-0210160, US-A-4,874,368, US-A-4,978,336, DE-A-42 23 356, EP-B-0315222, WO-A-96/19940, WO-A-95/31137 and WO-A-98/40167). Depending on the application, it is sometimes necessary and desirable to deliver the medium dose. In order devices for medical tissue adhesives, it is particularly desirable that the doses are reproducible and relatively low. This information set is to be independent of the duration of manual operation of the application device beyond.

For reasons of hygiene, it is furthermore advantageous if the application devices are designed as single-use or disposable items. This in turn requires that the mechanisms for the metered and independent from the operation of the application device media delivery are relatively simple in construction. Should in addition to the medium, a gas output, which can be sprayed on an object the output medium, so it makes sense to control the dosing standing for the medium by the underexposed compressed gas. Such a coating apparatus for industrial media is known from EP-A-0548509. However, this known application device is not suitable due to their very complicated structure for use in disposable or disposables.

The invention has for its object to provide an applicator for flowable media, which has a simple structure which is suitable for the design of the application device as one-way and one-off items.

To achieve this object an applicator device is proposed with the invention that is provided with at least one storage container for the medium, the

Having a storage container outlet opening from which the medium at

Pressurizing the medium and / or the Vorratsbehaltnisses from this outlet, a pressure generating element for pressurizing the medium and / or the Vorratsbehaltnisses, a biasing means for biasing the pressure generating element, wherein said biasing means includes a moveable run biasing member pneumatically in the direction of the pressure generating element and / or is hydraulically biased and coupled with this, a controllable locking means for locking the

Said biasing member, said locking a movable

comprises locking element which in at least one locking position, the

locked biasing member against the bias caused by movements and for releasing the biasing member from the at least one

Locking position can be moved out, and a release means for selectively releasing the locking, wherein the release means comprises a release member for temporarily moving the locking element from the at least one locking position.

Further embodiments of the invention are specified in the subclaims.

The dispensed with the inventive apparatus flowable medium is located in a storage container having an outlet opening. Provided that it is a multi-component medium wherein the medium is to be mixed with one another only during dispensing, a storage container is provided for each component. The medium is discharged from the storage container by means of hydraulic pressure. The pressure acting on the medium is applied by a pressure generating member. This pressure generating element acts either on the left in the storage container medium or from outside the storage container, which must be flexible in this case. In the former case is used as a storage container, in particular a syringe whose piston is the pressure generating element with the piston rod.

In the inventive device which stands for the output of the causal medium pressure generating member under a pretension This is realized in that the pressure generating element is biased by a biasing means in the direction towards the storage container. This biasing means operates pneumatically and / or hydraulically, in particular the pressure of a gas is used, which is optionally also used for spraying of the output medium. The biasing means comprises a biasing member that is coupled to the pressure generating element. The biasing member is biased against the pressure generating element. The freedom of movement of the biasing member is limited by means of a locking device. The locking device locks in its basic state, the movement of the biasing member in the direction of the pressure generating element. Using a release means arresting the biasing member may be released in a targeted and for predetermined time intervals. The release device has a release element that introduces the biasing member arretierendes locking element briefly in a position in which the locking element releases the biasing member.

The biasing means conveniently comprises a medical syringe, at whose outlet a connected to a source of compressed gas hose is connected. The syringe is supported on its piston rod end and to the flanges or wings of their cylinder between a fixed point and the biasing member. the piston and piston rod is forced out of the barrel of the syringe or biased in outwardly directed direction by pressurization. This pressure is utilized to move the biasing member in the direction of the force acting on the storage container for the medium pressing member.

The locking device is expediently designed in the form of interengaging with one another teeth. The biasing means, and more particularly, the biasing member is provided for this purpose with at least one rack with which co-operates a locking projection of the locking member. the locking projection is engaged with the rack, a movement of the urging member is prevented. such by movement of the locking member, that the locking device is disengaged from the rack, the biasing means and the biasing member is released so that the biasing force following is advanced. The release of the biasing means and the biasing member is controlled by the release element, which in turn moves the locking member. The teeth, that the succession of the teeth of the rack determines the extent to which the biasing member can will advance when it is released. Unless desired that extremely small amounts of fluid be dispensed, the rack must have a corresponding fine toothing. A fine toothing but again is disadvantageous, as the engagement of the locking projection with the rack requires a high degree of manufacturing precision. But this production accuracy can be realized only with increased effort in injection-molded plastic parts, how they should be used with preference in the inventive device. The background for this is that the inventive apparatus is to be designed as a single-use or disposable items. In that regard, it is advantageous to use coarser toothed racks. To write small dosing even with such a toothing, it is advantageous to provide, instead of a rack two racks on the biasing means and the biasing member are offset, in particular by a fraction of the spacing of the teeth preferably are arranged in the half tooth distance from each other , Consequently, also instructs the locking element has two locking projections. These locking projections and the racks are arranged at respective opposite or opposite sides of the locking member and the biasing member. By reciprocation of the locking member alternately in each case one of the locking projections is immersed in one of the racks. In the intermediate stages of movement of the locking member, the biasing member is not free, so that the desired step by step forward movement is limited only by the alternate engagement of the locking projections in the racks and the intent of the Zahnstangenanordnüng. The locking element is secured in both positions by locking against unintentional movements exerted on the element in question rack due to prestressing a Klemrnkraft on the detection. This is enough to keep the locking element engages the respective rack.

Is carried out only with a rack, it is expediently provided by a mechanical bias of the locking member for the fact that this is after release of the biasing member automatically returns to the state of the locking mechanism (the locking protrusion while immersed in the rack a) moves. The release member then works against the force of bias by moving the locking member of the locking device against the biasing force.

As already stated above, there is a mechanical coupling between the pneumatically or hydraulically biased biasing member and the pressure generating element, which acts on the fluid or the reservoir in order to output the medium. The biasing member may be, for a directly coupled to the pressure generating element or connected. As an alternative, it is advisable to realize the coupling via an intermediate or connecting element. This connecting member is then expediently designed as an operating element for manually moving the pressure generating element. The actuator relies on biasing element, and can be manually move relative thereto and secured against accidental displacement. An in this respect advantageous embodiment of the actuating element is a spindle, which is in threaded engagement with the biasing member. The one end of the spindle is connected via a rotatably mounted holder or a rotatably supported connecting element to the pressure generating member, while the other element or the like of a hand wheel. having grip with which can rotate the spindle. By this configuration, it is possible to manually move the pressure generating element alternative to the biasing member. This has the advantage that the inventive apparatus can be used optionally for manually outputting a no longer limited in terms of volume amount of medium. In this application, the pressure generating element is then moved away from the biasing member by actuation of the spindle. If the storage container formed like a syringe, this spindle can also be used to in order to suck through the outlet of the syringe of this medium to be dispensed. Here, then by actuation of the spindle, the pressure generating member moves toward the biasing member, thereby forming in the cylinder of the syringe, a vacuum, as a result, the (later) outputted medium is drawn into the cylinder of the syringe.

The inventive device is advantageously housed in a pistol-like housing, which is convenient for the Applizierung of the medium and thus for handling. Such a housing has a handle on which expediently an actuatable with a finger operating member in the form of a push button, lever or the like. is arranged. For reasons of space it is also advantageous if the the medium-containing storage container is accommodated lying in such a housing. This in turn means that also the pressure generating element is arranged horizontally, so moving parallel to the movement of the actuating element. As the pressure generating element is coupled to the biasing member, the biasing force also ensures that the biasing element is parallel to the actuating element movable. This movement of the biasing member, in turn, is effective to be prevented by the locking member then or targeted release when this locking element can be moved transversely to the biasing member so as to lock the biasing member on the one hand and on the other hand release. This means in effect that the movement with which the biasing member is released of the actuating element, in order to be deflected substantially 90 ° in order to move the locking element transversely. This Bewegungsumsetzeinrichtung is expediently provided with a pivot element which is pivotable about a transverse to the directions of movement of the release and the locking member pivot axis. The pivot member is coupled to the locking member and has an arm to which the release element acts. When the release member pushes against the pivot arm, the pivot member is pivoted about the pivot axis. As a result of the coupling of the pivot member with the locking member is associated with this pivoting movement, a linear movement of the locking member. Such an arrangement is suitable to, in order to transfer the locking member to a locking position to a release position. The backward movement of the locking member from the release position into the locking position is expediently carried out as a result of mechanical force applied to the locking member biasing force.

Is selected as the locking and release mechanism, a construction with an alternately movable between two locking positions detent member, so, the pivot member of the motion converting means comprises two opposed pivoting arms, on which acts the release element alternately. Characterized the pivot member is alternately pivoted in different directions, causing a movement of the locking member from the one detent position to the other locking position. With this construction, the shape of the pivot member is like a "T", whose horizontal leg forms the two swivel arms and its vertical leg is coupled to the locking element, wherein the point of intersection of the two legs, the pivot axis is disposed. As already explained above, it is sometimes desirable to use the spraying by means of a device of the type output medium according to the invention. This requires the synchronous dispensing of a gas, wherein the gas discharge 4ioch should take place for a certain time interval after completion of the medium discharge, so that a droplet formation of the medium is prevented at the outlet of the device. for this purpose, advantageously which is controlled by the pressure of the gas, whose output is to be affected by the valve is a gas release valve controlling employed. While it is desirable that the on state of the gas discharge valve is taken sharply as possible to the transfer of the Vent take place with a time delay from the ON state to the OFF state ils. This is advantageously realized by a "differential" -Gasabgabeventil whose housing comprises two interconnected chambers of different diameter or cross-sectional areas. In the two chambers a piston. An is particularly opposite ends of the two chambers are gas inlet ports, at which the under pressurized gas properties are connected lines leading. in the chamber with the smaller cross-section there is a gas outlet, while the chamber with the larger cross-section has an openable when required Entlüftungsöffhung. This vent opening is closed in the normal state by a closure member.

When locked, the valve, the Entlüftungsöffhung is closed. Da (hereinafter referred to as first chamber) the associated chamber has a larger cross-section (called second hereinafter chamber) than the other chamber and the gas pressure is equal in both chambers, acts on the in the first chamber end face of the piston a greater force than to the face of the piston located in the second chamber. As a result, the piston shifts in the direction of the second chamber, until it abuts against an area defined by a shoulder-like tapering region of the housing end stop. In this state, the piston of this seals the Gasauslaßöffiiung the second chamber.

By opening the Entlüftungsöffhung the pressure in the first chamber is reduced abruptly. In contrast, the full pressure of the gas is to continue in the second chamber. As a result, the piston moves into the first chamber, whereby the Gasauslaßöffiiung the second chamber is released. Now, the present at the gas inlet of the first chamber gas is discharged via the gas outlet of the first chamber; the valve is in its open position.

Once the Entlüftungsöffhung is closed again, the pressure in the first chamber rises again, on the value of the pressure in the second chamber. Because of the larger piston end face in the first chamber, the piston moves back towards the second chamber until it closes the Gasauslaßöffiiung in its end position. The speed at which this takes place depends on the one hand on the ratio of face sizes of the piston, on the other hand also on the rate at which the gas flows into the first chamber. This rate can be obtained by a choke or the like. be limited durchflußratenbestimmendes element and set so that the valve exhibits the desired temporal switching behavior.

The invention is explained below with reference to the drawing. In detail:

Fig. 1 is a side view showing the overall construction of the apparatus, Fig. 2 shows a detail of Fig. 1,

Fig. 3 shows the situation of the apparatus in the state immediately before the application of the medium,

Fig. 4 shows a detail of Fig. 3,

Fig. 5 is a plan view of the device according to Fig. 3,

Fig. 6 shows the device in the state after initial operation of the operating member and immediately before the leakage of medium,

Fig. 7 exits the state of the device at befindlichem in an intermediate position of the actuating element and in phase in the medium,

Fig. 8 shows the state of the apparatus with a fully-pressed, actuating element and again unterbundener medium discharge,

Fig. 9 shows the state of the device after the complete release of the actuator,

FIGS. 10 and 11 are enlarged view of the locking and release mechanism, and

FIGS. 12 to 25 are perspective views and sectional views of the operating member and details thereof in conjunction with the movement coupling of the actuation and release member with the locking member in various phases of the manual actuation of the actuating element.

The general structure of the apparatus 10 according to the invention is hereinafter with reference to FIGS. 1 to 5 explained in more detail. The apparatus 10 illustrated in the drawing serves for the metered delivery of a two-component tissue adhesive which is sprayed with the aid of a gas. The apparatus 10 comprises a housing 12 in which a dual chamber dispensing device 14 can be accommodated in FIG. 5. This device 14 is described in WO-A-98/10703, which is hereby also incorporated by reference to the content of this application. This device 14 has two formed as a syringe body storage containers 16 in which pistons 18 are slidably arranged on piston rods 20th The outlets 22 of the syringe body 16 are each connected via a special three-way valve 24 with the inlets of a head piece 26, to whose outlet a multi-lumen catheter is 28th 26 In addition, the connecting head or a gas connection 30th The structure of the three-way valves 24 is described in detail in WO-A-98/10703 and described in detail. Because of these details and the overall structure of the device 14 is full of content reference is made to this document.

As is apparent from the above description, the two-component tissue adhesive is therefore issued hydraulically. The piston 18 with piston rods 20 can thereby be regarded as pressure-generating elements. On the piston rods 20 acts via a connecting member 32 is a biasing means 34 having a biasing member 36th The biasing member 36 is connected via the connecting member 32 with the piston rods 20th Further, the biasing member in the direction is biased at the piston rods 20, which is realized pneumatic in this case. Here, the Spritzenköφer 38 of a syringe 40 with its flanges 42 on the biasing member 36 is supported. The piston rod 44 of syringe 40 is supported on a fixed bearing 46 of the housing 12th To the syringe outlet 48, a hose 50 is connected, which is connected via a Y-connector 52 to the next from an external source of pressurized gas connecting tube 54th By building up in the Spritzenköφer 38 pressure, the piston rod is pushed out 44 "backwards" from the Spritzenköφer 38 and thus pressed against the fixed bearing 46th As a result, has an effect on the biasing member 36 is a biasing force that the biasing member 36 "forward" and thus presses against the piston rods 20, whereupon exert this pressure on the medium.

By a time-limited release of the induced by the biasing movement of the biasing member 36 can now be targeted and dosed tissue adhesive from the storage containers 16 output. The biasing member 36 is guided axially displaceably in the housing 12th A can be brought into and out of engagement with the biasing member 36 locking member 56 a locking device 58 controls the release or locking of the biasing member 36. The locking member 56 is pre-transversely to the direction of the biasing member 36 and moved back. It surrounds the manner of a ring or a sleeve-like cylindrical part 60 of the biasing member 36, which is toothed at two diametrically opposite outer surface areas so that two rows of teeth or toothed racks 62,64 are formed. The rows of teeth or toothed racks 62,64 locking projections 66,68 of the locking member 56 are each arranged opposite, which can be brought alternately depending on the position of the locking member 56 in engagement with the projections respectively opposite and associated rack 62.64. While in the two end points of the linear movement of the locking member 56, the biasing member 36 is each latched, it can move freely when neither of the two detent protrusions is during the linear movement of the locking member 56 66.68 with the two racks 62,64 in engagement. This feature will be discussed in more detail below.

As already stated above, the biasing member 36 and the piston rods 20 are mechanically coupled via the connecting member 32 with each other. This connecting element 32 is designed as a spindle 70 which is in threaded engagement with the biasing member 36th 70 on the piston rods 20 end facing the spindle on a connecting or Aufhahmeteil 72 on which the Tellerflansche 74 of the piston rods are mounted in a clamping 20 and which is rotatably mounted on the spindle 70th The spindle 70 extends through an internally threaded, the projection 76 of the urging member 36 therethrough and has a hand wheel 78 at its the Aufiiahmeteil 72 opposite end. By manually turning the handwheel 78 can be - with a fixed biasing element 36 - move in the storage containers 16 the piston rods 20th This function is required, for example, to suck in the state of the apparatus of Fig. 1 in the supply containers 16 via the three-way valves 24, the components of the tissue adhesive contained in ampoule 80th In addition, it is possible, the piston rods inside move by reverse rotation of the spindle 70 20 into the storage containers 16 in order to make by hand for dispensing tissue glue. The movement of the locking member 56 is controlled by a release device 81 having a pin-shaped release member 82 which is transversely forward to the movement direction of the locking member 56 upon actuation of an actuating element 84 designed as an actuating button and moved back. The operating knob 84 is arranged in the handle portion of the housing 12 and can in this against the force of a spring 86 in moving. Coaxially with the operating knob 84 is received in this a cap 88 which supports the release pin 82nd The cap 88 is also biased by a return spring 90, the biasing direction of the cap 88 is equal to the Vorspamirichtung of the operation knob 84th The cap 88 facing away from the front end of the release pin 82 acts on the operating knob 84 is a to a rocker-type pivoting element 92 which can be tilted about a pivot axis 94 of the housing 12 and is pivotable. The pivot member 92 is provided with two pivot arms 96,98 that the swiveling axis 94 extend on both sides of a straight line. Transverse to the pivot arms 96,98, a projection 100 extends, which forms one part of a ball joint, whose other part is formed at the locking member 56th The pivot member 96 is in this manner that is, in mechanical connection with the locking member 56. By pivoting the pivot member 92 so that the locking element can be pre- 56 and back.

The release pin 82 is guided by a double-link guide 102nd As a result of this management of the release pin 82 is moved both linearly upon actuation of the actuator button 84 and deflected transversely to this direction of movement. The dual sliding guide 102 comprises two oblique to the linear direction of movement of the release pin guide grooves 104,106 into which a cam projection 108 of the release pin 82 is immersed. By the double-link guide 102 of the release pin is alternately positioned in two different feeding positions in which the release pin 82 undergoes transverse deflections different in repeated pressing the operation button 84 82nd The resilience of the transversely deflected in one or both of the feed positions release pin 82 is utilized. The dual sliding guide 102 functions similarly to refill writing instrument in which the writing lead by repeatedly pressing on an operation button in a disengaged position, in which it is locked, and a retreat position is transferred.

The use of these known double slotted guide 102 in the apparatus 10 has the advantage that with repeated actuation DES operation knob 84, the rocker-like pivoting member 92 tilts alternately in opposite directions or pivoted so that by repeated actuation of the actuator button 84 on the by the pivot member 92 realized Bewegungsumlenknngseinrichtung 110, the locking member 56 between its pre-locking position and can be moved back, in which it is alternately connected to one of the two racks 62,64 engage and lock the biasing member 36th

By pressing the operation button 84 is not only the media output but also the delivery of gas is controlled with the device 10 in question here, however. A hose 112 is in fact connected to the gas port 30 of the connecting head piece 26 which is connected to the gas outlet port 114 of a gas pressure-controlled valve 116th This valve 116 has a Gaseinlaßöffhung 118, to which a hose 120 is connected, which is connected to one terminal of the Y-connector 52nd About the Gaseinlaßöffhung 118, the gas to be controlled enters the valve 116, and is left there in dependence of the position of a control piston 122 to the gas outlet 1 14 and thus to the connecting headpiece 26th The valve 116 includes a valve housing 123 having a first or control chamber 124 and a second or gas passage 126 which is provided with the Gaseinlaßöffhung -118 and the gas outlet 114th The first chamber 124 has a larger cross section than the second chamber 126th The control piston 122 seals in its wider cross-section end within the first chamber 124 and, in its narrower in cross-section end in the second chamber 126 from sealingly. In the first chamber 124, a control line 128 which is connected to a Gaseinlaßöffhung 129 this chamber 124 and is connected to the Y- connector 52 leads. In the first chamber 124 further houses a Entlüftungsöffhung 130, which is closed by a biased into a closed position closing element 132nd The closure member 132 has an operating arm 134 which is arranged in a path of the follower member 136, which is connected to the operating knob 84th

In the normal position, the valve 116 takes its closing state in which the spool 122 is so far immersed in the second chamber 126, that it closes the gas outlet 114th This condition is a result of the fact that both sides of the piston acts gas the same gas pressure and due to the different sizes of end faces of the piston acting on the piston 122 displacement force in the direction of the second chamber 126 is established. By opening the vent opening 130, the pressure in the first chamber is reduced abruptly 124th Characterized the control piston 122 moves into the first chamber 124 and releases the gas outlet 1 14, so that now a fluid connection between the gas inlet and the gas outlet 114 is. Once the Entlüftungsöffhung 130 is closed again, the control piston 122 moves back into its closed position. Thereby delaying this motion, and in particular does not take place abruptly, is located in the control line 128, a flow restriction element 138 in the form of a throttle or the like.

Now that the basic construction of the device is described 10 may reference to FIGS. 6 are reproduced in a simple manner to 9 which occupies the intermediate stages of operation device 10 in response to actuation of the actuator button 84th not only the tissue adhesive dispensing, but also the gas delivery is controlled by pressing the operation button 84th As can be seen with reference to FIG. 6, is first operated the valve 116 at the start of operation of the operating knob 84, as a result of the pivoting away of the closure member (s. FIG. 6) of the control piston 122, the free Gasauslaßöffiiung are 114. Therefore, gas flows out of the catheter 28th At this time, the release pin 82 is not yet or only just in engagement with the pivot member 92. Upon further actuation of the release pin 82 pushes on the swing arm 98 of the pivot member 92, whereby this is swiveled, and thus the locking member 56 from the previously assumed locking position is transferred over a short time occupied release position to the second locking position. For the period during which none of the locking projections 66,68 of the locking member 56 engaged with the racks 62,64 in engagement, the biasing member may advancing 36 and thus the piston rods 20 move into the storage containers sixteenth This has the consequence that the tissue adhesive is output through the catheter 28 (s. Figs. 6 and 7). When fully pressed-operating knob 84 (s. Fig. 8) closes the closure element 132, the Entlüftungsöffhung 130 of the valve accordingly 116. Time delayed moves the spool 122 back into the second chamber 126 in order to close with taking its final position the Gasauslaßöffiiung 114th This means that flows for a short time after release of tissue adhesive nor gas from the catheter 28th Thus, should a drop of tissue adhesive at the end of the catheter 28 form, it will be sprayed by the inflowing gas.

After releasing the operation knob 84, the situation is one according to Fig. 9. As can be seen, is the release pin 82 in a direction opposed to the position of FIG. 1 is further engaged in the housing 12 position, its free end the swivel arm 96 is opposed to the release pin had not acted in the previous advancement 82. That is, 84 now the release pin acts at the next operation of the operating button 82 to the swing arm 96, which has the consequence that the locking member 56 is transferred from the position of FIG. 9 again in the position of FIG. 1.

FIGS. 10 and 11 again show in enlarged scale the interaction and the construction of the locking member 56 and the cylindrical portion 60 of the biasing member 36. The locking member 56 surrounds like a ring the portion 60 of the biasing member 36 and engages alternately, depending on the displacement position, with its locking projections 66,68 into one of the two sets of teeth 62,64.

As shown in FIGS. 13, 17, 18, 20, 22 and 24 shown, clamp both return springs 86,90, the coupled with them elements (operating knob 84, and cap 88) are each in a disengaged position. 84, since the position of the release pin 82 is different with the one behind the other in the direction of movement of the release pin 82 guide grooves 104,106 due to the dual sliding guide 102, the operation button, however, should always be moved back regardless after a release in one and the same starting position, it is necessary in addition to the cap 88 acting spring 90 of the second spring 86 for returning the actuator button 84. Because this would not exist double spring arrangement, so in the state of FIG. 18, the operation button 84 would not fully retracted. but this is necessary for a sake of improved feel and handling of the device 10, on the other hand due to the operation of the closure member 132 of the valve 116 by the push button 84th

From FIGS. 12 to 25 It is also clear that the release pin 82 is moved via a spring arm integrally ausgbildeten 139 against the plate 140, having the two guide grooves 104,106. This pressing is advantageous to provide independent of acting on the release pin 82 shocks for the fact that the cam projection 108 of the release pin remains immersed in one of the two guide grooves 104,106 82nd

Figs. 12 to 25 finally illustrate the different feed and Ausschwenkpositionen of the release pin 82 in dependence on the position of the operation knob 84 and the sequence of its operation. The starting point for the following description is the situation according to Fig 13, the cam projection 108 of the release pin 82 is in this position in the -. With respect to the feed motion of the release pin 82 in the direction of the pivot member 110 - first guide groove 106. Upon operation of the operation knob 84 the release pin 82 is deflected forcibly downward (relative to the depiction in the figures) (dash-dotted lines in Fig. 13 indicates). When the cam projection 108 is located at the end of the guide groove 106, the release pin 82 is moved away from the plate 140, since the cam projection 108 has at its free front end of an inclined surface 142 which causes this disengagement movement of the release pin 82 when the cam projection 108 located on the end of the guide groove 106 is, and will continue to act on the actuating button 84th Thus when from the guide groove 106 herausbewegtem cam projection 108 of the deflected in this state, the release pin is moved back 82 due to its resiliency is not back to its straight position of FIG. 13, the plate 140 a step 144 having a leading edge 146, along which the cam projection slides along the guide groove 108 to the second 104, so long as it is moved out of the guide groove 106 (see Fig., the intermediate positions shown in Figs. 15 to 17). The leading edge 146 thus connects the bottom in the drawing plane, both ends of the inclined guide grooves of the double-link guide 106.104 102nd

In the position shown in Fig. 17, the cam projection 108 is located in the the pivot member 110 facing the guide groove 104. Further, the guide pin 82 functions to the pivot member 110 and a twisted this. After releasing the operation knob 84, the guide pin (s FIGS.. 18 and 19) 82 moves as a result of the return spring 90 back until the cam projection 108 at which the operation knob 84 facing towards the end of the guide groove 104 is applied. If, starting from this position, the actuator button 84 is pressed again (s. Figs. 20 and 21), the release pin 82 is advanced again in the direction of the pivoting element 110. Due to the immersion of the Mitnehmervorsprungs 108 in the guide groove 104, it would now transversely come back to a deflection movement of the guide pin 82 to its linear direction of movement. However, the guide groove 104 has in its curved region 148 (s. also FIG. 17) has a Einfangaussparung 150, into which the cam projection 108 is immersed (s. Fig. 21). Thus, the cam projection 108 does not follow the oblique course of the guide groove 104, but rather moves due to the inclined surface 142 of the guide groove 104, more specifically from 150 Einfangaussparung out. Thus, the release pin 82 so moved substantially linearly forward, but still has a slight deflection due to - certain Rückstellfahigkeit on. This resilience causes the release pin 82 straightens out and thereby be cam projection 108 in a position above the guide groove 104 reaches (s. Fig. 22). In addition to the fact that the release pin 82 acts on the pivot member 110 upon further forward movement (s. Figs. 22, 23), has the movement of the Mitnehmervorsprungs 108 into the area above the guide groove 104, the result is that now upon release of the pushbutton 84 (s. Fig. 24) of the cam projection 108 slides past the side of the upper end of the guide groove 104 to be immersed into the upper end of the guide groove 106 (see FIG. FIGS. 24 and 25). then, from there arises at the next operation of the push button 84 again, the same sequence of movements as a has been described above based on Fig. 12.

Claims

1. Apparatus for applying a flowable medium, in particular a tissue adhesive, with
- at least one storage container (16) for the medium, wherein the storage container (16) has an outlet opening (22) from which the medium upon pressurization of the medium and / or the Vorratsbehaltnisses (16) emerging therefrom,
- a pressure generating element (20) for pressurizing the medium and / or the Vorratsbehaltnisses (16)
- a biasing means (34) for biasing the pressure generating element (20), said biasing means (34) comprises a movable run biasing member (36) which is in the direction of the pressure generating element (20) biased pneumatically and / or hydraulically and coupled thereto,
- a controllable locking means (58) for locking the biasing member (36), wherein the locking means (58) comprises a movable locking element (54), the biasing member in at least one locking position (36) locked against caused by the bias of movement and to release the biasing member (36) from the at least one locking position can be moved out, and
- a release device (81) for selectively releasing the locking means (58), wherein the release means (81) comprises a release element (82) for temporarily moving the locking member (56) from which at least a parking position.
having and 2. The device according to claim 1, characterized in that the biasing means (34) with the biasing member (36) coupled to said first rack (62) that the locking member (56) comprises a first locking projection (66) for immersion in the first rack ( 62).
3. Device according to claim 2, characterized in that the locking element (56) is biased into a locking position, in which its first locking projection (66) is immersed in the first rack (62), and that the locking element (54) of the release element (82) is movable against the bias out of this locking position.
comprises 4. A device according to claim 2, characterized in that the biasing means (34) has a second rack (64) and that the locking element (56) has a second locking projection (68) for immersion in the second rack (64).
5. Device according to claim 4, characterized in that the two racks (62,64) opposite to each other and the two locking projections (66,68) are associated with one another facing and that the locking element (56) of the release element (82) between two locking positions in each of which one of the locking projections (66,68) in one of the racks (62,64) is immersed, movable back and forth.
6. Device according to one of claims 1 to 5, characterized in that the biasing means (34) comprises a fluid pressure cylinder (38) with a piston (44) between a fixed point (46) and the biasing member (36) and / or in are arranged the biasing member (36), and that the fluid pressure cylinder (38) has a connection (48) for a fluid pressure line (50) connectable to a fluid pressure source or to a fluid pressure source is connectable.
7. A device according to any one of claims 1 to 6, characterized in that the biasing member (36) to the pressure generating element (20) is directly connected and / or connectable.
8. Device according to one of claims 1 to 6, characterized in that the biasing member (36) is connected to the pressure generating element (20) via an actuating element (32) for manually moving the pressure generating element (20) coupled to said actuating element (32) displaceably and secured against unintentional displacement of the biasing element (36) and led to the pressure generating element (20) is connectable.
9. The apparatus of claim 8, characterized in that the actuating element (32) in threaded engagement with the biasing member (36) rotating spindle (70) rotatably supported at its one end with a connecting element (72) for the pressure generating element (20) and has a hand wheel (78) for manually rotating the spindle (70) at its other end.
10. Device according to one of claims 1 to 9, characterized in that the release means (81) comprises a manually movable actuating member (84) for moving the release element (82), wherein the direction of movement of the release element (82) at an angle (to the moving direction of the locking member 56) runs and (between the two motion conversion means 110) is arranged.
11. The device according to claim 10, characterized in that the moving means of the release element (82) is perpendicular to the direction of movement of the locking member (56).
12. The apparatus of claim 10 or 11, characterized in that the movement conversion means (110) comprises a pivot member (92) pivotally that a to the directions of movement of the release element (82) and of the fixing element (56) transversely extending pivot axis (94) and with the locking element (56) is movably coupled to and at least one pivot arm (96,98) on said release element (82) for rotation of the pivot member (92) and thus to the displacement of the locking member (56) upon actuation of the actuating element (84) acts.
13. The apparatus according to claim 12, characterized in that the pivoting element (92) having two opposing swing arms (96,98) to which the release element (82) alternately acts upon repeated actuation of the actuating element (84), wherein the relative position of the release element (82) changed for the pivoting member (92) during repeated actuation of the actuating element (84) alternately between a first position to act on the one pivot arm (96) and a second position for acting on the other arm (98).
14. Device according to one of claims 1 to 13, characterized in that a gas discharge valve (116) for synchronized with the medium outlet discharge of gas is provided, that the gas discharge valve (116) having a first and a second chamber (124,126), which between themselves are connected, wherein
- a larger cross section than the second chamber (126) having the first chamber (124),
- between the two chambers (124,126), a shoulder portion is disposed,
- both chambers (124,126) having inlet openings (118.129) for the entry of pressurized gas from a common compressed gas source,
- the first chamber (124) in addition with a Entlüftungsöffhung (130) is provided, which is closable by a pre-stressed in the closed position of closure element (132) which is movable upon actuation of the release element (82) against the bias in a Öffhungsstellung,
- the second chamber (126) has a gas outlet (114) and
- in both chambers (124,126), a slidable control piston (122) is arranged which closes in its resting against the shoulder portion position the gas outlet (114) of the second chamber (126) and upon movement of the shoulder portion away the gas outlet (114) of the second chamber (126) releases it.
15. Device according to claim 14, characterized in that the Gaseinlaßöffhung (129) of the first chamber (124) a choke (138) is connected upstream or these Gaseinlaßöffhung (129) is designed as a throttle, wherein the in the first chamber (124) entering gas flows through a smaller cross-sectional passage area than that in the second chamber (126) incoming gas.
EP20000909342 1999-03-09 2000-03-08 Device for applying a flowable medium, notably a tissue adhesive Withdrawn EP1159081A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE19910972 1999-03-09
DE1999110972 DE19910972C1 (en) 1999-03-09 1999-03-09 Apparatus for applying a flowable medium, in particular a tissue adhesive
PCT/EP2000/002017 WO2000053339A1 (en) 1999-03-09 2000-03-08 Device for applying a flowable medium, notably a tissue adhesive

Publications (1)

Publication Number Publication Date
EP1159081A1 true EP1159081A1 (en) 2001-12-05

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EP20000909342 Withdrawn EP1159081A1 (en) 1999-03-09 2000-03-08 Device for applying a flowable medium, notably a tissue adhesive

Country Status (6)

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US (1) US6565539B1 (en)
EP (1) EP1159081A1 (en)
JP (1) JP2002537962A (en)
AU (1) AU3165600A (en)
DE (1) DE19910972C1 (en)
WO (1) WO2000053339A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7658305B2 (en) 2006-10-25 2010-02-09 Ethicon Endo-Surgery, Inc. Adhesive applier with articulating tip
US7749235B2 (en) 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
US7833216B2 (en) 2006-11-08 2010-11-16 Ethicon Endo-Surgery, Inc. Fluid plunger adhesive dispenser
US7892250B2 (en) 2006-11-01 2011-02-22 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive on inflatable device for gastric restriction
US7914511B2 (en) 2006-10-18 2011-03-29 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive as bulking agent
US8608642B2 (en) 2010-02-25 2013-12-17 Ethicon Endo-Surgery, Inc. Methods and devices for treating morbid obesity using hydrogel
US8876844B2 (en) 2006-11-01 2014-11-04 Ethicon Endo-Surgery, Inc. Anastomosis reinforcement using biosurgical adhesive and device

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6585696B2 (en) 2000-12-22 2003-07-01 Baxter International, Inc. Method and apparatus for applying a medically useful multiple component material
US6852099B2 (en) * 2002-06-04 2005-02-08 Baxter International Inc. Device for controllably applying liquids to body surfaces
US8419722B2 (en) * 2004-10-29 2013-04-16 Spinal Restoration, Inc. Apparatus and method for injection of fibrin sealant in spinal applications
US20110213464A1 (en) * 2004-10-29 2011-09-01 Whitlock Steven I Injection of fibrin sealant in the absence of corticosteroids in spinal applications
US7597687B2 (en) * 2004-10-29 2009-10-06 Spinal Restoration, Inc. Injection of fibrin sealant including an anesthetic in spinal applications
US8206448B2 (en) 2004-10-29 2012-06-26 Spinal Restoration, Inc. Injection of fibrin sealant using reconstituted components in spinal applications
BRPI0606642A2 (en) * 2005-01-12 2009-07-14 Baxter Int device and tissue sealant spray system operated by hand
JP5007056B2 (en) * 2006-03-13 2012-08-22 テルモ株式会社 Applicator
WO2007139758A2 (en) * 2006-05-22 2007-12-06 Orthovita, Inc. Delivery of multicomponent compositions
US8096449B2 (en) * 2006-07-17 2012-01-17 Medmix Systems Ag Dispensing appliance for a multiple cartridge
US20090062741A1 (en) * 2006-11-14 2009-03-05 Emery Smith Dual lumen syringe
US8002736B2 (en) * 2007-12-21 2011-08-23 Carticept Medical, Inc. Injection systems for delivery of fluids to joints
US8545440B2 (en) 2007-12-21 2013-10-01 Carticept Medical, Inc. Injection system for delivering multiple fluids within the anatomy
US9044542B2 (en) 2007-12-21 2015-06-02 Carticept Medical, Inc. Imaging-guided anesthesia injection systems and methods
US7959612B2 (en) * 2008-04-21 2011-06-14 Medtronic Vascular, Inc. Dual syringe injector system
WO2010095128A2 (en) * 2009-02-20 2010-08-26 Omrix Biopharmaceuticals Ltd. Device for administering an at least two-component substance
WO2011056992A2 (en) * 2009-11-04 2011-05-12 Graco Minnesota Inc. Integrated valving rod lubrication cartridge
EP2513700B1 (en) 2009-12-18 2016-08-24 Redring AB Aiming device with a reticle defining a target area at a specified distance
AU2011229797B2 (en) * 2010-03-23 2017-02-16 Hyperbranch Medical Technology, Inc. Disposable syringe applicators for multi-component formulations, and methods of use thereof
US20110245866A1 (en) * 2010-04-05 2011-10-06 Neomend, Inc. Method and apparatus for wound sealant application
US9211554B2 (en) * 2010-06-30 2015-12-15 Actamax Surgical Materials, Llc Self-contained hand-held direct drive device for dispensing a two-part adhesive aerosol
US20120000935A1 (en) * 2010-06-30 2012-01-05 E. I. Du Pont De Nemours And Company Self-contained hand held yoke-connected device for dispensng a two-part adhesive aerosol
US8678238B2 (en) * 2010-06-30 2014-03-25 Actamax Surgical Materials, Llc Self-contained hand-held yoke-connected device for dispensing a two-part adhesive aerosol
IL207715D0 (en) 2010-08-19 2010-12-30 Omrix Biopharmaceuticals Device for administering fluids and use thereof
US9398913B2 (en) * 2012-08-24 2016-07-26 St. Jude Medical Puerto Rico Llc Sealant storage, preparation, and delivery systems and related methods
DE102013103552A1 (en) * 2013-04-09 2014-10-09 Ivoclar Vivadent Ag syringe

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2049299A5 (en) * 1969-06-06 1971-03-26 Dieny Alfred
US3606100A (en) * 1970-02-13 1971-09-20 Amf Inc Device for dispensing a concentrated fluid stream
AT366916B (en) * 1980-04-02 1982-05-25 Immuno Ag A device for applying a tissue adhesive based on human or tierischenproteinen
AT379311B (en) * 1984-03-29 1985-12-27 Immuno Ag A device for applying a tissue adhesive
AT382783B (en) * 1985-06-20 1987-04-10 Immuno Ag A device for applying a tissue adhesive
DE3704210A1 (en) * 1987-02-11 1988-08-25 Friedhelm Schneider Dosing for liquids and pastes
US4978336A (en) * 1987-09-29 1990-12-18 Hemaedics, Inc. Biological syringe system
US4874368A (en) * 1988-07-25 1989-10-17 Micromedics, Inc. Fibrin glue delivery system
US5046642A (en) * 1989-12-26 1991-09-10 Arthur Macke Automatic spring-loaded tuckpointing gun
DK166691D0 (en) * 1991-09-30 1991-09-30 Unes As Flerkomponentsproejte
DE4137801C2 (en) * 1991-11-16 1993-08-26 Deutsche Tecalemit Gmbh, 4800 Bielefeld, De
DE4223356A1 (en) * 1992-07-16 1994-01-20 Octapharma Ag Glarus Multicomponent prod. applicator with head with component ducts - which are formed by rigid cannulae incorporated in head, coupled with front ends to respective hose lumens
DK0634140T4 (en) * 1992-09-26 2004-09-06 Chemo Sero Therapeut Res Inst Applicator for tissue adhesive
US5584815A (en) * 1993-04-02 1996-12-17 Eli Lilly And Company Multi-cartridge medication injection device
WO1995031137A1 (en) * 1994-05-18 1995-11-23 Omrix Biopharmaceuticals S.A. Dispenser for a multi-component tissue adhesive
EP0800361B1 (en) * 1994-12-28 1999-05-19 Omrix Biopharmaceuticals S.A. Device for applying one or several fluids
ES2192231T3 (en) * 1996-09-10 2003-10-01 Omrix Biopharm Sa Applicator for applying a multi-component fluid.
DE19709896C1 (en) * 1997-03-11 1998-12-24 Omrix Biopharm Sa An applicator for applying a one- or multi-component fluid and method for spraying a fluid such
DE29711075U1 (en) * 1997-06-25 1997-08-21 Wenzler Medizintechnik Gmbh An apparatus for injecting Sklerusierungsmitteln
WO1999002207A1 (en) * 1997-07-11 1999-01-21 United States Surical Corp. Fibrin glue applicator system
DE19753146A1 (en) * 1997-11-29 1999-06-02 Wuerth Adolf Gmbh & Co Kg Output device for cartridges

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0053339A1 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7914511B2 (en) 2006-10-18 2011-03-29 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive as bulking agent
US7749235B2 (en) 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
US7658305B2 (en) 2006-10-25 2010-02-09 Ethicon Endo-Surgery, Inc. Adhesive applier with articulating tip
US7892250B2 (en) 2006-11-01 2011-02-22 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive on inflatable device for gastric restriction
US8876844B2 (en) 2006-11-01 2014-11-04 Ethicon Endo-Surgery, Inc. Anastomosis reinforcement using biosurgical adhesive and device
US7833216B2 (en) 2006-11-08 2010-11-16 Ethicon Endo-Surgery, Inc. Fluid plunger adhesive dispenser
US8608642B2 (en) 2010-02-25 2013-12-17 Ethicon Endo-Surgery, Inc. Methods and devices for treating morbid obesity using hydrogel

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Publication number Publication date
US6565539B1 (en) 2003-05-20
AU3165600A (en) 2000-09-28
WO2000053339A1 (en) 2000-09-14
JP2002537962A (en) 2002-11-12
DE19910972C1 (en) 2000-10-26

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