EP1151002A4 - Antibodies specific to kdr and uses thereof - Google Patents
Antibodies specific to kdr and uses thereofInfo
- Publication number
- EP1151002A4 EP1151002A4 EP00913280A EP00913280A EP1151002A4 EP 1151002 A4 EP1151002 A4 EP 1151002A4 EP 00913280 A EP00913280 A EP 00913280A EP 00913280 A EP00913280 A EP 00913280A EP 1151002 A4 EP1151002 A4 EP 1151002A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- kdr
- antibodies specific
- antibodies
- specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24073699A | 1999-01-29 | 1999-01-29 | |
US11772699P | 1999-01-29 | 1999-01-29 | |
US117726P | 1999-01-29 | ||
US240736 | 1999-01-29 | ||
PCT/US2000/002180 WO2000044777A1 (en) | 1999-01-29 | 2000-01-28 | Antibodies specific to kdr and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1151002A1 EP1151002A1 (en) | 2001-11-07 |
EP1151002A4 true EP1151002A4 (en) | 2002-05-02 |
Family
ID=26815579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00913280A Withdrawn EP1151002A4 (en) | 1999-01-29 | 2000-01-28 | Antibodies specific to kdr and uses thereof |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1151002A4 (en) |
JP (1) | JP2002536968A (en) |
CN (1) | CN1345334A (en) |
AU (1) | AU3475100A (en) |
CA (1) | CA2361553A1 (en) |
IL (1) | IL144578A0 (en) |
WO (1) | WO2000044777A1 (en) |
Families Citing this family (104)
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---|---|---|---|---|
ATE338120T2 (en) | 1998-11-27 | 2006-09-15 | Ucb Sa | COMPOSITIONS AND METHODS FOR INCREASE BONE MINERALIZATION |
US20030092091A1 (en) | 2000-03-07 | 2003-05-15 | Abrahamson Julie A. | Sialoadhesin factor-2 antibodies |
EP1272205B1 (en) * | 2000-03-07 | 2013-08-07 | The Johns Hopkins University | Sialoadhesin factor-2 antibodies |
JP2004511430A (en) * | 2000-05-24 | 2004-04-15 | イムクローン システムズ インコーポレイティド | Bispecific immunoglobulin-like antigen binding protein and production method |
NZ525140A (en) * | 2000-09-14 | 2005-10-28 | Biogen Idec Inc | Tweak receptor and Fn14 agonists as anti-angiogenic agents |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
RU2420537C2 (en) * | 2001-01-17 | 2011-06-10 | Трабьон Фармасьютикалз Инк. | Fused proteins binding immunoglobulin domain |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
EP1411983A4 (en) * | 2001-06-26 | 2006-06-21 | Imclone Systems Inc | Bispecific antibodies that bind to vegf receptors |
GB0124317D0 (en) | 2001-10-10 | 2001-11-28 | Celltech R&D Ltd | Biological products |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
EP2301587B1 (en) * | 2002-03-01 | 2014-06-25 | Dyax Corp. | KDR and VEGF/KDR binding peptides and their use in diagnosis |
CA2513044A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
US7498414B2 (en) | 2002-03-04 | 2009-03-03 | Imclone Systems Incorporated | Human antibodies specific to KDR and uses thereof |
PT1523496E (en) | 2002-07-18 | 2011-09-29 | Merus B V | Recombinant production of mixtures of antibodies |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
GB0312481D0 (en) * | 2003-05-30 | 2003-07-09 | Celltech R&D Ltd | Antibodies |
WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
RU2431500C2 (en) | 2003-06-09 | 2011-10-20 | Самуэль ВАКСАЛ | Method for receptor tyrosine kinase inhibition with use extracellular antagonist and intracellular antagonist |
US7754209B2 (en) | 2003-07-26 | 2010-07-13 | Trubion Pharmaceuticals | Binding constructs and methods for use thereof |
WO2006089095A2 (en) | 2005-02-17 | 2006-08-24 | Biogen Idec Ma Inc. | Treating neurological disorders |
US7592429B2 (en) * | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
US8362075B2 (en) | 2005-05-17 | 2013-01-29 | Merck Sharp & Dohme Corp. | Cyclohexyl sulphones for treatment of cancer |
EP1912675B1 (en) | 2005-07-25 | 2014-02-12 | Emergent Product Development Seattle, LLC | B-cell reduction using cd37-specific and cd20-specific binding molecules |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
US8409577B2 (en) | 2006-06-12 | 2013-04-02 | Emergent Product Development Seattle, Llc | Single chain multivalent binding proteins with effector function |
EP2083831B1 (en) | 2006-09-22 | 2013-12-25 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
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KR20100017866A (en) | 2007-05-21 | 2010-02-16 | 노파르티스 아게 | Csf-1r inhibitors, compositions, and methods of use |
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CL2008002775A1 (en) | 2007-09-17 | 2008-11-07 | Amgen Inc | Use of a sclerostin binding agent to inhibit bone resorption. |
WO2009082437A2 (en) | 2007-12-21 | 2009-07-02 | Ligand Pharmaceuticals Incorporated | Selective androgen receptor modulators (sarms) and uses thereof |
JP6013733B2 (en) | 2008-04-11 | 2016-10-25 | エマージェント プロダクト デベロップメント シアトル, エルエルシー | CD37 immunotherapeutic and its combination with bifunctional chemotherapeutics |
JP5670877B2 (en) | 2008-04-15 | 2015-02-18 | ファーマサイクリックス,インク. | Selective inhibitors of histone deacetylase |
EP2413932A4 (en) | 2009-04-01 | 2012-09-19 | Merck Sharp & Dohme | Inhibitors of akt activity |
CN101531718B (en) * | 2009-04-22 | 2011-11-02 | 中国人民解放军南京军区军事医学研究所 | Anti-VEGFR-2 antibody chimeric Fab antibody fragment, preparation method and application thereof |
JP6073677B2 (en) | 2009-06-12 | 2017-02-01 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Fused heterocyclic compounds and their use |
US8128932B2 (en) | 2009-08-17 | 2012-03-06 | Shanghai Aosaiersi Biotech Co., Ltd. | Anti-VEGFR monoclonal antibody, method of making and uses thereof |
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CA2777043C (en) | 2009-10-14 | 2015-12-15 | Schering Corporation | Substituted piperidines that increase p53 activity and the uses thereof |
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EP2569010B1 (en) | 2010-05-14 | 2017-04-12 | Amgen, Inc | High concentration antibody formulations |
US8999957B2 (en) | 2010-06-24 | 2015-04-07 | Merck Sharp & Dohme Corp. | Heterocyclic compounds as ERK inhibitors |
US9193792B2 (en) | 2010-07-07 | 2015-11-24 | Tubitak | Recombinant antibody structures binding to and blocking the activity of vascular endothelial growth factor 2 (VEGFR—2/KDR) |
US8518907B2 (en) | 2010-08-02 | 2013-08-27 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA) |
EP2606134B1 (en) | 2010-08-17 | 2019-04-10 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
WO2012030685A2 (en) | 2010-09-01 | 2012-03-08 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
WO2012036997A1 (en) | 2010-09-16 | 2012-03-22 | Schering Corporation | Fused pyrazole derivatives as novel erk inhibitors |
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US9351965B2 (en) | 2010-12-21 | 2016-05-31 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as ERK inhibitors |
CN103649118A (en) | 2011-03-01 | 2014-03-19 | 安进公司 | Bispecific binding agents |
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WO2013074986A1 (en) | 2011-11-17 | 2013-05-23 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-jun-n-terminal kinase (jnk) |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991016353A1 (en) * | 1990-04-23 | 1991-10-31 | Corvas International N.V. | Thrombus-specific antibody derivatives |
WO1998011223A1 (en) * | 1996-09-11 | 1998-03-19 | Schering Aktiengesellschaft | Monoclonal antibodies against the extracellular domain of human vegf-receptor protein (kdr) |
WO1999040118A1 (en) * | 1998-02-04 | 1999-08-12 | Kyowa Hakko Kogyo Co., Ltd. | Antibodies against human vegf receptor kdr |
WO1999060025A1 (en) * | 1998-05-20 | 1999-11-25 | Kyowa Hakko Kogyo Co., Ltd. | Gene recombinant antibodies |
EP1086705A1 (en) * | 1998-05-20 | 2001-03-28 | Kyowa Hakko Kogyo Co., Ltd. | Vegf activity inhibitors |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5861499A (en) * | 1994-02-10 | 1999-01-19 | Imclone Systems Incorporated | Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain |
-
2000
- 2000-01-28 WO PCT/US2000/002180 patent/WO2000044777A1/en not_active Application Discontinuation
- 2000-01-28 IL IL14457800A patent/IL144578A0/en unknown
- 2000-01-28 AU AU34751/00A patent/AU3475100A/en not_active Abandoned
- 2000-01-28 JP JP2000596033A patent/JP2002536968A/en not_active Withdrawn
- 2000-01-28 CN CN00805856A patent/CN1345334A/en active Pending
- 2000-01-28 CA CA002361553A patent/CA2361553A1/en not_active Abandoned
- 2000-01-28 EP EP00913280A patent/EP1151002A4/en not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991016353A1 (en) * | 1990-04-23 | 1991-10-31 | Corvas International N.V. | Thrombus-specific antibody derivatives |
WO1998011223A1 (en) * | 1996-09-11 | 1998-03-19 | Schering Aktiengesellschaft | Monoclonal antibodies against the extracellular domain of human vegf-receptor protein (kdr) |
WO1999040118A1 (en) * | 1998-02-04 | 1999-08-12 | Kyowa Hakko Kogyo Co., Ltd. | Antibodies against human vegf receptor kdr |
WO1999060025A1 (en) * | 1998-05-20 | 1999-11-25 | Kyowa Hakko Kogyo Co., Ltd. | Gene recombinant antibodies |
EP1086705A1 (en) * | 1998-05-20 | 2001-03-28 | Kyowa Hakko Kogyo Co., Ltd. | Vegf activity inhibitors |
Non-Patent Citations (4)
Title |
---|
HICKLIN D J ET AL: "MONOCLONAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) RECEPTOR (KDR) ANTIBODIES WHICH ARE INHIBITORS OF VEGF BINDING AND ANTAGONISTS OF VEGF-STIMULATED SIGNALING AND GROWTH OF HUMAN ENDOTHELIAL CELLS", PROCEEDINGS OF THE 89TH. ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. NEW ORLEANS, LA, MARCH 28 - APRIL 1, 1998, PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, PHILADELPHIA, PA: AACR, US, vol. 39, March 1998 (1998-03-01), pages 96, XP000918907 * |
See also references of WO0044777A1 * |
WITTE L ET AL: "MONOCLONAL ANTIBODIES TARGETING THE VEGF RECEPTOR-2 (FLK1/KDR) AS AN ANTI-ANGIOGENIC THERAPEUTIC STRATEGY", CANCER AND METASTASIS REVIEWS, KLUWER ACADEMIC PUBLISHERS, DORDRECHT, NL, vol. 17, no. 2, 1998, pages 155 - 161, XP000940443, ISSN: 0167-7659 * |
ZHU Z ET AL: "Inhibition of vascular endothelial growth factor-induced receptor activation with anti-kinase insert domain-containing receptor single-chain antibodies from a phage display library", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 58, no. 15, 1 August 1998 (1998-08-01), pages 3209 - 3214, XP002141908, ISSN: 0008-5472 * |
Also Published As
Publication number | Publication date |
---|---|
CA2361553A1 (en) | 2000-08-03 |
IL144578A0 (en) | 2002-05-23 |
JP2002536968A (en) | 2002-11-05 |
CN1345334A (en) | 2002-04-17 |
AU3475100A (en) | 2000-08-18 |
EP1151002A1 (en) | 2001-11-07 |
WO2000044777A1 (en) | 2000-08-03 |
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