EP1126833A4 - Oxadiazole, thiadiazole and triazole derivatives and combinatorial libraries thereof - Google Patents

Oxadiazole, thiadiazole and triazole derivatives and combinatorial libraries thereof

Info

Publication number
EP1126833A4
EP1126833A4 EP99971314A EP99971314A EP1126833A4 EP 1126833 A4 EP1126833 A4 EP 1126833A4 EP 99971314 A EP99971314 A EP 99971314A EP 99971314 A EP99971314 A EP 99971314A EP 1126833 A4 EP1126833 A4 EP 1126833A4
Authority
EP
European Patent Office
Prior art keywords
thiadiazole
oxadiazole
combinatorial libraries
triazole derivatives
triazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99971314A
Other languages
German (de)
French (fr)
Other versions
EP1126833A2 (en
Inventor
R Normand Hebert
Amy L Hannah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trega Biosciences Inc
Original Assignee
Trega Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trega Biosciences Inc filed Critical Trega Biosciences Inc
Publication of EP1126833A2 publication Critical patent/EP1126833A2/en
Publication of EP1126833A4 publication Critical patent/EP1126833A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11Compounds covalently bound to a solid support

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Structural Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP99971314A 1998-10-29 1999-10-28 Oxadiazole, thiadiazole and triazole derivatives and combinatorial libraries thereof Withdrawn EP1126833A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US183222 1994-01-14
US18322298A 1998-10-29 1998-10-29
PCT/US1999/025331 WO2000025768A1 (en) 1998-10-29 1999-10-28 Oxadiazole, thiadiazole and triazole derivatives and combinatorial libraries thereof

Publications (2)

Publication Number Publication Date
EP1126833A2 EP1126833A2 (en) 2001-08-29
EP1126833A4 true EP1126833A4 (en) 2004-09-08

Family

ID=22671958

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99971314A Withdrawn EP1126833A4 (en) 1998-10-29 1999-10-28 Oxadiazole, thiadiazole and triazole derivatives and combinatorial libraries thereof

Country Status (3)

Country Link
EP (1) EP1126833A4 (en)
AU (1) AU1455500A (en)
WO (1) WO2000025768A1 (en)

Families Citing this family (33)

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AU5891600A (en) * 1999-07-01 2001-01-22 Chemrx Advanced Technologies, Inc. Process for synthesizing oxadiazoles
WO2001054503A1 (en) * 2000-01-28 2001-08-02 Akkadix Corporation Methods for killing nematodes and nematode eggs using 4-phenoxy-6-aminopyrimidine derivatives
US6683191B2 (en) 2000-06-05 2004-01-27 Ortho-Mcneil Pharmaceuticals, Inc. Method for synthesis of substituted azole libraries
US6951948B2 (en) 2000-06-05 2005-10-04 Ortho-Mcneil Pharmaceutical, Inc. Method for synthesis of substituted azole libraries
US6482829B2 (en) * 2000-06-08 2002-11-19 Hoffmann-La Roche Inc. Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
HUE031794T2 (en) 2003-04-11 2017-08-28 Ptc Therapeutics Inc 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
US7335658B2 (en) 2003-07-30 2008-02-26 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
GB0325956D0 (en) * 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
WO2005058848A1 (en) 2003-12-17 2005-06-30 Merck & Co., Inc. (3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists
US7453002B2 (en) 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
MX2007003327A (en) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase.
EP2269610A3 (en) 2004-09-20 2011-03-09 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AU2005286648A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
AR051092A1 (en) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc HETEROCICLIC DERIVATIVES AND THEIR USE AS INHIBITORS OF ESTEAROIL-COA
TW200626138A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
CN101083992A (en) 2004-09-20 2007-12-05 泽农医药公司 Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
GB0508319D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
CA2618646A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
EP2007365A2 (en) 2006-03-30 2008-12-31 PTC Therapeutics, Inc. Methods for the production of functional protein from dna having a nonsense mutation and the treatment of disorders associated therewith
WO2008013622A2 (en) 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
US9090604B2 (en) 2006-07-27 2015-07-28 E I Du Pont De Nemours And Company Fungicidal azocyclic amides
MX2009002019A (en) 2006-08-24 2009-03-09 Novartis Ag 2- (pyrazin-2-yl) -thiazole and 2- (1h-pyraz0l-3-yl) -thiazole derivatives as well as related compounds as stearoyl-coa desaturase (scd) inhibitors for the treatment of metabolic, cardiovascular and other disorders.
AU2007334436A1 (en) 2006-12-15 2008-06-26 Abbott Laboratories Novel oxadiazole compounds
WO2010108187A2 (en) * 2009-03-20 2010-09-23 Brandeis University Compounds and methods for treating mammalian gastrointestinal microbial infections
AR081626A1 (en) 2010-04-23 2012-10-10 Cytokinetics Inc AMINO-PYRIDAZINIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME TO TREAT CARDIAC AND SKELETIC MUSCULAR DISORDERS
AR081331A1 (en) 2010-04-23 2012-08-08 Cytokinetics Inc AMINO- PYRIMIDINES COMPOSITIONS OF THE SAME AND METHODS FOR THE USE OF THE SAME
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
US9447134B2 (en) 2012-08-17 2016-09-20 Brandeis University Compounds and methods for treating mammalian gastrointestinal microbial infections
KR102497273B1 (en) 2014-03-06 2023-02-07 피티씨 테라퓨틱스, 인크. Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid
MX2018005361A (en) 2015-10-30 2018-06-07 Ptc Therapeutics Inc Methods for treating epilepsy.
CN112010828B (en) * 2020-09-27 2023-01-31 中国医科大学 CDK7 small-molecule inhibitor compound and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019330A1 (en) * 1993-02-18 1994-09-01 Warner-Lambert Company Heterocyclic-substituted alkyl amide acat inhibitors
WO1996022997A1 (en) * 1995-01-27 1996-08-01 Novo Nordisk A/S Compounds with growth hormone releasing properties
WO1997014671A1 (en) * 1995-10-18 1997-04-24 Merck & Co., Inc. Cyclopentyl tachykinin receptor antagonists
WO1997016433A1 (en) * 1995-10-30 1997-05-09 Smithkline Beecham Corporation Protease inhibitors
WO1998037068A1 (en) * 1997-02-21 1998-08-27 Bristol-Myers Squibb Company Benzoic acid derivatives and related compounds as antiarrhythmic agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8801289D0 (en) * 1988-01-21 1988-02-17 Shell Int Research Oxadiazole compounds their preparation & their use as pesticides
US5242890A (en) * 1988-07-07 1993-09-07 Korea Research Institute Of Chemical Technology 1,2,4-oxadiazole derivative, useful as selective herbicide

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019330A1 (en) * 1993-02-18 1994-09-01 Warner-Lambert Company Heterocyclic-substituted alkyl amide acat inhibitors
WO1996022997A1 (en) * 1995-01-27 1996-08-01 Novo Nordisk A/S Compounds with growth hormone releasing properties
WO1997014671A1 (en) * 1995-10-18 1997-04-24 Merck & Co., Inc. Cyclopentyl tachykinin receptor antagonists
WO1997016433A1 (en) * 1995-10-30 1997-05-09 Smithkline Beecham Corporation Protease inhibitors
WO1998037068A1 (en) * 1997-02-21 1998-08-27 Bristol-Myers Squibb Company Benzoic acid derivatives and related compounds as antiarrhythmic agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO0025768A1 *
SUSANNA BORG: "synthesis of 1,2,4-oxadiazole-", JOURNAL OF ORGANIC CHEMISTRY., vol. 60, no. 10, 1995, USAMERICAN CHEMICAL SOCIETY. EASTON., pages 3112 - 20, XP002288337 *

Also Published As

Publication number Publication date
EP1126833A2 (en) 2001-08-29
WO2000025768A8 (en) 2000-08-24
WO2000025768A1 (en) 2000-05-11
AU1455500A (en) 2000-05-22

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Legal Events

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: HANNAH, AMY, L.

Inventor name: HEBERT, R., NORMAND

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61P 43/00 B

Ipc: 7C 07D 271/10 B

Ipc: 7C 07D 271/06 B

Ipc: 7A 61K 31/10 B

Ipc: 7A 61K 31/075 A

A4 Supplementary search report drawn up and despatched

Effective date: 20040723

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: HANNAH, AMY, L.

Inventor name: HEBERT, R., NORMAND