EP1119375A4 - Methods and adjuvants for stimulating mucosal immunity - Google Patents

Methods and adjuvants for stimulating mucosal immunity

Info

Publication number
EP1119375A4
EP1119375A4 EP99949664A EP99949664A EP1119375A4 EP 1119375 A4 EP1119375 A4 EP 1119375A4 EP 99949664 A EP99949664 A EP 99949664A EP 99949664 A EP99949664 A EP 99949664A EP 1119375 A4 EP1119375 A4 EP 1119375A4
Authority
EP
European Patent Office
Prior art keywords
adjuvants
methods
mucosal immunity
stimulating mucosal
stimulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99949664A
Other languages
German (de)
French (fr)
Other versions
EP1119375A1 (en
Inventor
Eyal Raz
Anthony A Horner
Dennis A Carson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
REGETNS OF UNIVERSITY OF C
University of California
Original Assignee
REGETNS OF THE UNIVERSITY OF C
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US167039 priority Critical
Priority to US16703998A priority
Application filed by REGETNS OF THE UNIVERSITY OF C, University of California filed Critical REGETNS OF THE UNIVERSITY OF C
Priority to PCT/US1999/021203 priority patent/WO2000020039A1/en
Publication of EP1119375A1 publication Critical patent/EP1119375A1/en
Publication of EP1119375A4 publication Critical patent/EP1119375A4/en
Application status is Withdrawn legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/544Mucosal route to the airways
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
EP99949664A 1998-10-05 1999-09-15 Methods and adjuvants for stimulating mucosal immunity Withdrawn EP1119375A4 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US167039 1988-03-11
US16703998A true 1998-10-05 1998-10-05
PCT/US1999/021203 WO2000020039A1 (en) 1998-10-05 1999-09-15 Methods and adjuvants for stimulating mucosal immunity

Publications (2)

Publication Number Publication Date
EP1119375A1 EP1119375A1 (en) 2001-08-01
EP1119375A4 true EP1119375A4 (en) 2005-02-02

Family

ID=22605695

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99949664A Withdrawn EP1119375A4 (en) 1998-10-05 1999-09-15 Methods and adjuvants for stimulating mucosal immunity

Country Status (5)

Country Link
EP (1) EP1119375A4 (en)
JP (1) JP2002526425A (en)
AU (1) AU776288B2 (en)
CA (1) CA2346452A1 (en)
WO (1) WO2000020039A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US20030026782A1 (en) 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
EP1176966B1 (en) 1999-04-12 2013-04-03 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Oligodeoxynucleotide and its use to induce an immune response
EP1322655B1 (en) 2000-01-14 2007-11-14 The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services Oligodeoxynucleotide and its use to induce an immune response
CA2398756A1 (en) 2000-01-31 2001-08-02 Eyal Raz Immunomodulatory polynucleotides in treatment of an infection by an intracellular pathogen
EP1267618A1 (en) 2000-03-28 2003-01-02 Department of Veterans Affairs Methods for increasing a cytotoxic t lymphocyte response in vivo
US7682607B2 (en) 2001-05-01 2010-03-23 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
AT544466T (en) 2002-10-29 2012-02-15 Coley Pharm Group Inc Use of CpG oligonucleotides for treatment of hepatitis C virus infection
EP1572122A4 (en) 2002-11-01 2008-04-09 Us Gov Health & Human Serv Method of preventing infections from bioterrorism agents with immunostimulatory cpg oligonucleotides
CA2502015A1 (en) 2002-12-11 2004-06-24 Coley Pharmaceutical Group, Inc. 5' cpg nucleic acids and methods of use
EP1625850B1 (en) 2003-05-15 2012-02-29 Japan Science and Technology Agency Immunostimulating agents
JP4817625B2 (en) * 2003-08-11 2011-11-16 一般財団法人阪大微生物病研究会 A new vaccine, including mucosal immunity-inducing adjuvant
WO2006060710A2 (en) * 2004-12-02 2006-06-08 Becton, Dickinson And Company Vaccine formulations for intradermal delivery comprising adjuvants and antigenic agents
WO2007018152A1 (en) 2005-08-05 2007-02-15 The University Of Tokushima ANTIGEN-AND-DRUG VEHICLE WHICH ENABLES THE CHANGEOVER FROM THE SELECTIVE PRODUCTION OF IgA ANTIBODY TO THE PRODUCTION OF BOTH OF IgA AND IgG ANTIBODIES, AND TRANSNASAL/TRANSMUCOSAL VACCINE USING THE VEHICLE
IL208820D0 (en) * 2010-10-19 2011-01-31 Rachel Teitelbaum Biologic female contraceptives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002555A1 (en) * 1994-07-15 1996-02-01 The University Of Iowa Research Foundation Immunomodulatory oligonucleotides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2241042T3 (en) * 1996-10-11 2005-10-16 The Regents Of The University Of California Conjugates immunostimulatory polynucleotide / immunomodulatory molecule.
CA2301575C (en) * 1997-05-20 2003-12-23 Heather L. Davis Vectors and methods for immunization or therapeutic protocols
EP1009413B1 (en) * 1997-09-05 2007-02-14 The Regents Of The University Of California Use of immunostimulatory oligonucleotides for preventing or treating asthma

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002555A1 (en) * 1994-07-15 1996-02-01 The University Of Iowa Research Foundation Immunomodulatory oligonucleotides

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DAVIS H L ET AL: "CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 JAN 1998, vol. 160, no. 2, 15 January 1998 (1998-01-15), pages 870 - 876, XP002109526, ISSN: 0022-1767 *
KRIEG ARTHUR M ET AL: "The role of CpG dinucleotides in DNA vaccines", TRENDS IN MICROBIOLOGY, vol. 6, no. 1, January 1998 (1998-01-01), pages 23 - 27, XP000857633, ISSN: 0966-842X *
See also references of WO0020039A1 *
WEINER GEORGE J ET AL: "Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 94, no. 20, 1997, pages 10833 - 10837, XP002120387, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2000020039A9 (en) 2000-09-21
EP1119375A1 (en) 2001-08-01
AU776288B2 (en) 2004-09-02
JP2002526425A (en) 2002-08-20
AU6249399A (en) 2000-04-26
CA2346452A1 (en) 2000-04-13
WO2000020039A1 (en) 2000-04-13

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RIC1 Classification (correction)

Ipc: 7A 61K 48/00 A

Ipc: 7A 61K 39/39 B

Ipc: 7C 12N 15/00 B

18D Deemed to be withdrawn

Effective date: 20050331