EP1107747A4 - Therapies for treating pulmonary diseases - Google Patents

Therapies for treating pulmonary diseases

Info

Publication number
EP1107747A4
EP1107747A4 EP99941248A EP99941248A EP1107747A4 EP 1107747 A4 EP1107747 A4 EP 1107747A4 EP 99941248 A EP99941248 A EP 99941248A EP 99941248 A EP99941248 A EP 99941248A EP 1107747 A4 EP1107747 A4 EP 1107747A4
Authority
EP
European Patent Office
Prior art keywords
therapies
pulmonary diseases
treating pulmonary
treating
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99941248A
Other languages
German (de)
French (fr)
Other versions
EP1107747A1 (en
Inventor
Richard Nieman
Anthony S Rebuck
Theodore J Torphy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP1107747A1 publication Critical patent/EP1107747A1/en
Publication of EP1107747A4 publication Critical patent/EP1107747A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP99941248A 1998-08-26 1999-08-24 Therapies for treating pulmonary diseases Withdrawn EP1107747A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9797398P 1998-08-26 1998-08-26
US97973P 1998-08-26
PCT/US1999/019332 WO2000012078A1 (en) 1998-08-26 1999-08-24 Therapies for treating pulmonary diseases

Publications (2)

Publication Number Publication Date
EP1107747A1 EP1107747A1 (en) 2001-06-20
EP1107747A4 true EP1107747A4 (en) 2003-04-23

Family

ID=22266001

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99941248A Withdrawn EP1107747A4 (en) 1998-08-26 1999-08-24 Therapies for treating pulmonary diseases

Country Status (21)

Country Link
US (2) US6288118B1 (en)
EP (1) EP1107747A4 (en)
JP (1) JP2002523452A (en)
KR (1) KR20010072931A (en)
CN (1) CN1314811A (en)
AR (1) AR022072A1 (en)
AU (1) AU754379B2 (en)
BR (1) BR9913152A (en)
CA (1) CA2341488A1 (en)
CZ (1) CZ293735B6 (en)
DZ (1) DZ2876A1 (en)
HU (1) HUP0103160A3 (en)
IL (1) IL141335A0 (en)
MA (1) MA26302A1 (en)
MY (1) MY126544A (en)
NO (1) NO20010882D0 (en)
NZ (1) NZ527232A (en)
PE (1) PE20001032A1 (en)
PL (1) PL346271A1 (en)
TR (1) TR200100500T2 (en)
WO (1) WO2000012078A1 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6525018B1 (en) 1999-05-17 2003-02-25 The General Hospital Corp. Treating eye disorders using intestinal trefoil proteins
US6624181B1 (en) 1997-02-28 2003-09-23 Altana Pharma Ag Synergistic combination
US20030114384A1 (en) * 2001-11-28 2003-06-19 Podolsky Daniel K. Methods and compositions for treating lesions of the respiratory epithelium
US20030185838A1 (en) * 2001-11-28 2003-10-02 Podolsky Daniel K. Methods and compositions for treating lesions of the respiratory epithelium
US20030186882A1 (en) * 2001-07-31 2003-10-02 Podolsky Daniel K. Methods and compositions for treating and preventing distal bowel lesions
BR9913152A (en) * 1998-08-26 2001-05-15 Smithkline Beecham Corp Therapies for the treatment of lung diseases
US8933032B2 (en) 1998-10-20 2015-01-13 Children's Hospital Medical Center Surfactant protein D for the treatment of disorders associated with lung injury
CA2715683A1 (en) * 1999-08-21 2001-03-01 Nycomed Gmbh Synergistic combination
NZ522882A (en) 2000-06-05 2004-07-30 Altana Pharma Bv Pyridazinone compounds effective as beta-2-adrenoreceptor agonists as well as PDE4-inhibitors
US7538082B2 (en) 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
US20030105016A1 (en) * 2001-09-06 2003-06-05 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US20060189526A1 (en) * 2002-04-24 2006-08-24 Podolsky Daniel K Compositions containing an intestinal trefoil peptide and a mucoadhesive
US20040171544A1 (en) * 2001-04-24 2004-09-02 Barker Nicholas P. Trefoil domain-containing polypeptides and uses thereof
US20030181384A1 (en) * 2001-09-06 2003-09-25 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US20030185839A1 (en) * 2001-10-05 2003-10-02 Podolsky Daniel K. Methods and compositions for treating dermal lesions
WO2003030824A2 (en) * 2001-10-05 2003-04-17 The General Hospital Corporation Methods and compositions for treating dermal lesions
US7931022B2 (en) * 2001-10-19 2011-04-26 Respirks, Inc. Method and apparatus for dispensing inhalator medicament
GB0129395D0 (en) * 2001-12-07 2002-01-30 Pfizer Ltd Pharmaceutical combination
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
AU2003224773B2 (en) * 2002-03-26 2010-08-26 The General Hospital Corporation Combination therapy using trefoil peptides
RS95304A (en) * 2002-05-07 2006-12-15 Altana Pharma Ag. New combination fortreating airway disorders
DE10220458A1 (en) * 2002-05-07 2003-11-27 Altana Pharma Ag Treating respiratory diseases, e.g. bronchitis or asthma, using combination of proton pump inhibitor, e.g. omeprazole, and conventional respiratory therapeutic agent, e.g. cilomilast
DE10220459A1 (en) * 2002-05-07 2003-11-27 Byk Gulden Lomberg Chem Fab Treating respiratory diseases, e.g. bronchitis or asthma, using combination of reversible proton pump inhibitor, e.g. AU-461, and conventional respiratory therapeutic agent, e.g. cilomilast
US20050165041A1 (en) * 2002-05-07 2005-07-28 Altana Pharma Ag Combination for the treatment of airway disorders
US20060188471A1 (en) * 2002-10-31 2006-08-24 Podolsky Daniel K Methods of treating epithelial lesions
DK1567139T3 (en) * 2002-11-27 2008-11-03 Nycomed Gmbh Hitherto unknown synergistic combination including roflumilast and formoterol
NZ540658A (en) * 2002-11-27 2007-03-30 Altana Pharma Ag Synergistic combination comprising roflumilas and (R,R)-formoterol
ES2335498T3 (en) 2003-03-10 2010-03-29 Nycomed Gmbh NEW PROCESS FOR THE PREPARATION OF REFLUMILAST.
JPWO2004087151A1 (en) * 2003-03-31 2006-06-29 協和醗酵工業株式会社 Pharmaceutical composition
SE527200C2 (en) * 2003-06-19 2006-01-17 Microdrug Ag Administration of metered dry powder combined doses of finely divided dry medication powders involves selecting first and second medicaments for forming of pharmaceutical, combined doses
WO2005123072A1 (en) * 2004-06-14 2005-12-29 Sepracor Inc. Methods and compositions for the treatment of pulmonary diseases
CA2570386A1 (en) * 2004-06-14 2005-12-29 Sepracor Inc. Methods of using albuterol and calcium activated potassium channel openers
US8663694B2 (en) 2005-03-16 2014-03-04 Takeda Gmbh Taste masked dosage form containing roflumilast
DE102005030733A1 (en) * 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg New drug combinations for the treatment of respiratory diseases containing long-acting beta-2 agonists and at least one other active ingredient
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
KR20100014565A (en) * 2007-04-11 2010-02-10 알콘 리서치, 리미티드 Use of an inhibitor of tnfa plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis
ES2618881T3 (en) * 2009-04-22 2017-06-22 Indiana University Research And Technology Corporation Collagen V for use in the treatment of asthma
CN102548536A (en) * 2009-10-01 2012-07-04 爱尔康研究有限公司 Olopatadine compositions and uses thereof
KR101035488B1 (en) * 2009-10-05 2011-05-20 숭실대학교산학협력단 How to collect car black box video
WO2011056561A1 (en) 2009-10-27 2011-05-12 Beth Israel Deaconess Medical Center Methods and compositions for the generation and use of conformation-specific antibodies
CA2796826A1 (en) 2010-05-10 2011-11-17 Gilead Sciences, Inc. Bifunctional quinoline derivatives
UY33373A (en) 2010-05-10 2011-12-30 Gilead Sciences Inc ? Bifunctional pyrazolopyridine compounds, their use in therapy and compositions that comprise them ?.
US10487114B2 (en) 2011-04-27 2019-11-26 Beth Israel Deaconess Medical Center, Inc. Methods for administering peptides for the generation of effective c/s conformation-specific antibodies to a human subject in need thereof
WO2015063669A1 (en) 2013-10-30 2015-05-07 Wockhardt Limited Pharmaceutical compositions comprising combination of roflumilast and acebrophylline or pharmaceutically acceptable salts thereof
US10433624B2 (en) * 2015-03-26 2019-10-08 Nike, Inc. Duffel bag
US11866482B2 (en) 2018-02-07 2024-01-09 Duke University System and method for homogenous GPCR phosphorylation and identification of beta-2 adrenergic receptor positive allosteric modulators

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037894A1 (en) * 1997-02-28 1998-09-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Synergistic combination of pde inhibitors and adenylate cyclase agonists or guanyl cyclyse agonists

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE791025A (en) 1971-11-19 1973-05-07 Allen & Hanburys Ltd HETEROCYCLIC COMPOUNDS
GB1457873A (en) 1973-01-04 1976-12-08 Allen & Hanburys Ltd Imidazotriazines
FR2390164A1 (en) 1977-05-13 1978-12-08 Blanie Paul Anti:asthmatic methyl-xanthine compsns. - synergised with beta-sympathomimetic agents
US5602110A (en) 1994-08-31 1997-02-11 Case Western Reserve University Method and composition for treating cystic fibrosis
FR2753706B1 (en) 1996-09-20 1998-10-30 NOVEL N-SUBSTITUTED CYCLIC AMINES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2753969B1 (en) * 1996-09-27 1998-10-30 Adir NOVEL FLAVON DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
US5858694A (en) * 1997-05-30 1999-01-12 Cell Pathways, Inc. Method for identifying compounds for inhibition of cancerous lesions
BR9913152A (en) * 1998-08-26 2001-05-15 Smithkline Beecham Corp Therapies for the treatment of lung diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037894A1 (en) * 1997-02-28 1998-09-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Synergistic combination of pde inhibitors and adenylate cyclase agonists or guanyl cyclyse agonists

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BLEASE K ET AL: "MODULATION OF CELL ADHESION MOLECULE EXPRESSION AND FUNCTION ON HUMAN LUNG MICROVASCULAR ENDOTHELIAL CELLS BY INHIBITION OF PHOSPHODIESTERASES 3 AND 4", BRITISH JOURNAL OF PHARMACOLOGY, BASINGSTOKE, HANTS, GB, vol. 124, no. 1, May 1998 (1998-05-01), pages 229 - 237, XP000890110, ISSN: 0007-1188 *
KRASNOWSKA M ET AL: "[Treatment of bronchial asthma with small doses of papaverine combined with beta stimulators]", PNEUMONOLOGIA POLSKA. POLAND 1982 JAN-FEB, vol. 50, no. 1-2, January 1982 (1982-01-01), pages 21 - 24, XP008011100, ISSN: 0376-4761 *
MARMO E ET AL: "[Bronchial asthma and experimental evaluation of the antibronchospastic action of adrenaline, atropine and papaverine alone and in combinations]", ARCHIVIO MONALDI PER LA TISIOLOGIA E LE MALATTIE DELL'APPARATO RESPIRATORIO. ITALY 1976 MAY-JUN, vol. 31, no. 3, May 1976 (1976-05-01), pages 211 - 232, XP008011099, ISSN: 0004-0185 *
PLANQUOIS J M ET AL: "SALBUTAMOL POTENTIATES THE RELAXANT EFFECTS OF SELECTIVE PHOSPHODIESTERASE INHIBITORS ON GUINEA PIG ISOLATED TRACHEA", FUNDAMENTAL & CLINICAL PHARMACOLOGY, ELSEVIER, PARIS, FR, vol. 10, no. 4, 1996, pages 356 - 357, XP000889917, ISSN: 0767-3981 *
See also references of WO0012078A1 *
TANIZAWA MAKOTO ET AL: "Phosphodiesterase IV inhibitors synergistically potentiate relaxation induced by forskolin in guinea-pig trachea.", CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol. 25, no. 2, February 1998 (1998-02-01), pages 114 - 119, XP001064284, ISSN: 0305-1870 *
TURNER NICHOLAS C ET AL: "Relaxation of guinea-pig trachea by cyclic AMP phosphodiesterase inhibitors and their enhancement by sodium nitroprusside.", BRITISH JOURNAL OF PHARMACOLOGY, vol. 111, no. 4, 1994, pages 1047 - 1052, XP008011098, ISSN: 0007-1188 *

Also Published As

Publication number Publication date
CZ2001692A3 (en) 2002-02-13
NZ527232A (en) 2005-03-24
AR022072A1 (en) 2002-09-04
KR20010072931A (en) 2001-07-31
WO2000012078A1 (en) 2000-03-09
DZ2876A1 (en) 2003-12-15
AU5493999A (en) 2000-03-21
MY126544A (en) 2006-10-31
US20010056122A1 (en) 2001-12-27
JP2002523452A (en) 2002-07-30
US6555583B2 (en) 2003-04-29
EP1107747A1 (en) 2001-06-20
IL141335A0 (en) 2002-03-10
MA26302A1 (en) 2004-10-01
NO20010882L (en) 2001-02-21
HUP0103160A3 (en) 2002-11-28
HUP0103160A2 (en) 2002-01-28
US6288118B1 (en) 2001-09-11
BR9913152A (en) 2001-05-15
NO20010882D0 (en) 2001-02-21
CN1314811A (en) 2001-09-26
CA2341488A1 (en) 2000-03-09
PL346271A1 (en) 2002-01-28
TR200100500T2 (en) 2001-06-21
PE20001032A1 (en) 2000-11-10
CZ293735B6 (en) 2004-07-14
AU754379B2 (en) 2002-11-14

Similar Documents

Publication Publication Date Title
PL346271A1 (en) Therapies for treating pulmonary diseases
NO20004688D0 (en) Therapy for estrogen-associated disorders
GB9816263D0 (en) Therapeutic agents
GB9806102D0 (en) Therapeutic agents
GB9808663D0 (en) Therapeutic agents
GB9813576D0 (en) Therapeutic agents
GB9801234D0 (en) Therapeutic agents
GB9813006D0 (en) Therapeutic agents
GB9801210D0 (en) Therapeutic agents
AP9901436A0 (en) Therapeutic agents
GB9816556D0 (en) Therapy
GB9801397D0 (en) Therapeutic agents
GB9801202D0 (en) Therapeutic agents
GB9808665D0 (en) Therapeutic compounds
GB9810092D0 (en) Therapeutic agents
GB9824897D0 (en) Therapeutic compounds
GB9819484D0 (en) Therapeutic agents
GB9811879D0 (en) Therapeutic agents
GB9805716D0 (en) Therapeutic agents
ZA991786B (en) Therapeutic treatment for asthma.
HK1037539A (en) Therapies for treating pulmonary diseases
GB9815317D0 (en) Therapeutic agents
GB9816723D0 (en) Therapeutic agents
GB9817838D0 (en) Therapeutic agents
GB9808667D0 (en) Therapeutic compounds

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010213

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI PAYMENT 20010213

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 45/06 B

Ipc: 7A 61K 31/135 B

Ipc: 7A 61K 31/19 A

A4 Supplementary search report drawn up and despatched

Effective date: 20030306

17Q First examination report despatched

Effective date: 20031024

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20050627

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1037539

Country of ref document: HK