EP1086083A4 - Protease inhibitors - Google Patents
Protease inhibitorsInfo
- Publication number
- EP1086083A4 EP1086083A4 EP99928614A EP99928614A EP1086083A4 EP 1086083 A4 EP1086083 A4 EP 1086083A4 EP 99928614 A EP99928614 A EP 99928614A EP 99928614 A EP99928614 A EP 99928614A EP 1086083 A4 EP1086083 A4 EP 1086083A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- protease inhibitors
- protease
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8905698P | 1998-06-12 | 1998-06-12 | |
US89056P | 1998-06-12 | ||
PCT/US1999/013334 WO1999064399A1 (en) | 1998-06-12 | 1999-06-11 | Protease inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1086083A1 EP1086083A1 (en) | 2001-03-28 |
EP1086083A4 true EP1086083A4 (en) | 2001-09-26 |
Family
ID=22215426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99928614A Withdrawn EP1086083A4 (en) | 1998-06-12 | 1999-06-11 | Protease inhibitors |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1086083A4 (en) |
JP (1) | JP2002517485A (en) |
AR (1) | AR018652A1 (en) |
AU (1) | AU4564499A (en) |
CA (1) | CA2334652A1 (en) |
CO (1) | CO5040090A1 (en) |
DZ (1) | DZ2815A1 (en) |
MA (1) | MA24877A1 (en) |
PE (1) | PE20000725A1 (en) |
WO (1) | WO1999064399A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
WO2001034599A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
WO2001034156A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
US6583137B1 (en) | 1999-11-10 | 2003-06-24 | Smithkline Beecham Corporation | Protease inhibitors |
JP2003527429A (en) | 2000-03-21 | 2003-09-16 | スミスクライン・ビーチャム・コーポレイション | Protease inhibitor |
WO2002080920A1 (en) * | 2001-04-06 | 2002-10-17 | Axys Pharmaceuticals, Inc. | Arylacetamido-ketobenzoxazole as cysteine protease inhibitors |
WO2003062192A1 (en) | 2002-01-17 | 2003-07-31 | Smithkline Beecham Corporation | Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors |
EP2240491B1 (en) | 2008-01-09 | 2015-07-15 | Amura Therapeutics Limited | TETRAHYDROFURO(2,3-b)PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES |
WO2023041432A1 (en) | 2021-09-14 | 2023-03-23 | Boehringer Ingelheim International Gmbh | 3-phenoxyazetidin-1-yl-heteroaryl pyrrolidine derivatives and the use thereof as medicament |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995013069A1 (en) * | 1993-11-09 | 1995-05-18 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone |
WO1996016080A1 (en) * | 1994-11-21 | 1996-05-30 | Cortech, Inc. | Human neutrophil elastase inhibitors |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5770573A (en) * | 1993-12-06 | 1998-06-23 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
-
1999
- 1999-06-09 DZ DZ990115A patent/DZ2815A1/en active
- 1999-06-10 MA MA25619A patent/MA24877A1/en unknown
- 1999-06-10 AR ARP990102767A patent/AR018652A1/en unknown
- 1999-06-10 CO CO99036559A patent/CO5040090A1/en unknown
- 1999-06-11 WO PCT/US1999/013334 patent/WO1999064399A1/en not_active Application Discontinuation
- 1999-06-11 JP JP2000553408A patent/JP2002517485A/en not_active Withdrawn
- 1999-06-11 EP EP99928614A patent/EP1086083A4/en not_active Withdrawn
- 1999-06-11 AU AU45644/99A patent/AU4564499A/en not_active Abandoned
- 1999-06-11 CA CA002334652A patent/CA2334652A1/en not_active Abandoned
- 1999-06-11 PE PE1999000518A patent/PE20000725A1/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995013069A1 (en) * | 1993-11-09 | 1995-05-18 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone |
WO1996016080A1 (en) * | 1994-11-21 | 1996-05-30 | Cortech, Inc. | Human neutrophil elastase inhibitors |
Non-Patent Citations (3)
Title |
---|
See also references of WO9964399A1 * |
T.HOEG-JENSEN ET AL.: "Peptide Thioacylation with High Stereochemical Preservation", SYNTHESIS, vol. 3, 1996, pages 383 - 387, XP002173434 * |
THOMPSON S K ET AL: "DESIGN OF POTENT AND SELECTIVE HUMAN CATHEPSIN K INHIBITORS THAT SPAN THE ACTIVE SITE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 94, no. 26, 23 December 1997 (1997-12-23), pages 14249 - 14254, XP002913847, ISSN: 0027-8424 * |
Also Published As
Publication number | Publication date |
---|---|
AU4564499A (en) | 1999-12-30 |
MA24877A1 (en) | 1999-12-31 |
CA2334652A1 (en) | 1999-12-16 |
WO1999064399A1 (en) | 1999-12-16 |
JP2002517485A (en) | 2002-06-18 |
CO5040090A1 (en) | 2001-05-29 |
EP1086083A1 (en) | 2001-03-28 |
DZ2815A1 (en) | 2003-12-01 |
AR018652A1 (en) | 2001-11-28 |
PE20000725A1 (en) | 2000-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20001108 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): BE CH DE ES FR GB IT LI NL |
|
RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7C 07D 215/14 A, 7C 07D 261/08 B, 7C 07D 207/12 B, 7C 07D 207/24 B, 7C 07D 401/12 B, 7C 07D 413/14 B, 7A 61K 31/40 B |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20010810 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): BE CH DE ES FR GB IT LI NL |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: SMITHKLINE BEECHAM PLC Owner name: SMITHKLINE BEECHAM CORPORATION |
|
17Q | First examination report despatched |
Effective date: 20040312 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20040723 |