EP1069901A4 - Calcilytic compounds and method of use - Google Patents
Calcilytic compounds and method of useInfo
- Publication number
- EP1069901A4 EP1069901A4 EP99917374A EP99917374A EP1069901A4 EP 1069901 A4 EP1069901 A4 EP 1069901A4 EP 99917374 A EP99917374 A EP 99917374A EP 99917374 A EP99917374 A EP 99917374A EP 1069901 A4 EP1069901 A4 EP 1069901A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- calcilytic compounds
- calcilytic
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8108798P | 1998-04-08 | 1998-04-08 | |
| US81087P | 1998-04-08 | ||
| PCT/US1999/007760 WO1999051241A1 (en) | 1998-04-08 | 1999-04-08 | Calcilytic compounds and method of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1069901A1 EP1069901A1 (en) | 2001-01-24 |
| EP1069901A4 true EP1069901A4 (en) | 2001-06-13 |
Family
ID=22162024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP99917374A Withdrawn EP1069901A4 (en) | 1998-04-08 | 1999-04-08 | Calcilytic compounds and method of use |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1069901A4 (en) |
| JP (1) | JP2002510636A (en) |
| AR (1) | AR014975A1 (en) |
| AU (1) | AU3551399A (en) |
| CA (1) | CA2327188A1 (en) |
| CO (1) | CO5021223A1 (en) |
| WO (1) | WO1999051241A1 (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO5180628A1 (en) * | 1999-07-31 | 2002-07-30 | Smithkline Beecham Corp | CALCIOLITIC COMPOUNDS |
| MY159417A (en) * | 2000-01-24 | 2017-01-13 | Smithkline Beecham Corp | Calcilytic compounds |
| US20030018203A1 (en) | 2002-07-17 | 2003-01-23 | Largo Maria Amparo | Calcilytic compounds |
| PL365703A1 (en) * | 2000-07-21 | 2005-01-10 | Smithkline Beecham Corporation | Calcilytic compounds |
| FR2812875B1 (en) | 2000-08-08 | 2003-12-12 | Centre Nat Rech Scient | NOVEL DIAMINES HAVING CASR MODULATING ACTIVITY AND THEIR METHOD OF PREPARATION |
| CA2418794C (en) | 2000-08-11 | 2009-11-24 | Japan Tobacco, Inc. | Calcium receptor antagonists |
| US20040014723A1 (en) * | 2000-10-25 | 2004-01-22 | Pradip Bhatnagar | Calcilytic compounds |
| US6476046B1 (en) | 2000-12-04 | 2002-11-05 | Sepracor, Inc. | Diazabicyclo[4.3.0]nonanes, and methods of use thereof |
| ATE493987T1 (en) | 2002-05-22 | 2011-01-15 | Amgen Inc | AMINOPYRIMIDINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN |
| AR041191A1 (en) | 2002-08-08 | 2005-05-04 | Amgen Inc | VANILLOID RECEIVER LINKS AND THEIR USE IN TREATMENTS |
| TWI316511B (en) | 2002-11-26 | 2009-11-01 | Smithkline Beecham Corp | Calcilytic compounds |
| WO2004069793A2 (en) | 2003-01-28 | 2004-08-19 | Bristol-Myers Squibb Company | Novel 2-substituted cyclic amines as calcium sensing receptor modulators |
| US7205322B2 (en) | 2003-02-12 | 2007-04-17 | Bristol-Myers Squibb Company | Thiazolidine compounds as calcium sensing receptor modulators |
| TWI329628B (en) | 2003-04-23 | 2010-09-01 | Japan Tobacco Inc | Casr antagonist |
| EP1630157A4 (en) | 2003-05-28 | 2007-05-23 | Japan Tobacco Inc | CaSR ANTAGONIST |
| US7265145B2 (en) | 2003-05-28 | 2007-09-04 | Bristol-Myers Squibb Company | Substituted piperidines and pyrrolidines as calcium sensing receptor modulators and method |
| WO2005077938A1 (en) | 2004-02-11 | 2005-08-25 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| MY139645A (en) | 2004-02-11 | 2009-10-30 | Amgen Inc | Vanilloid receptor ligands and their use in treatments |
| WO2006089311A1 (en) | 2005-02-15 | 2006-08-24 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| WO2010103429A1 (en) | 2009-03-10 | 2010-09-16 | Pfizer Inc. | 1,1-(Dimethyl-Ethylamino)-2-Hydroxy-Propoxy]-Ethyl}-3-Methyl-Biphenyl-4- Carboxylic Acid Derivatives As Calcium Receptor Antagonists |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL83966A (en) * | 1986-09-26 | 1992-03-29 | Schering Ag | Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them |
| UY24949A1 (en) * | 1997-04-08 | 2001-04-30 | Smithkline Beecham Corp | CALCILITE COMPOUNDS |
-
1999
- 1999-04-06 AR ARP990101555A patent/AR014975A1/en not_active Application Discontinuation
- 1999-04-08 JP JP2000542012A patent/JP2002510636A/en not_active Withdrawn
- 1999-04-08 WO PCT/US1999/007760 patent/WO1999051241A1/en not_active Application Discontinuation
- 1999-04-08 CO CO99020600A patent/CO5021223A1/en unknown
- 1999-04-08 CA CA002327188A patent/CA2327188A1/en not_active Abandoned
- 1999-04-08 AU AU35513/99A patent/AU3551399A/en not_active Abandoned
- 1999-04-08 EP EP99917374A patent/EP1069901A4/en not_active Withdrawn
Non-Patent Citations (2)
| Title |
|---|
| No further relevant documents disclosed * |
| See also references of WO9951241A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2327188A1 (en) | 1999-10-14 |
| AR014975A1 (en) | 2001-04-11 |
| JP2002510636A (en) | 2002-04-09 |
| AU3551399A (en) | 1999-10-25 |
| EP1069901A1 (en) | 2001-01-24 |
| CO5021223A1 (en) | 2001-03-27 |
| WO1999051241A1 (en) | 1999-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20001030 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): BE CH DE ES FR GB IT LI NL |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20010426 |
|
| AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): BE CH DE ES FR GB IT LI NL |
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| RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7A 61K 31/535 A, 7A 01N 43/02 B, 7A 01N 43/40 B, 7A 01N 43/42 B, 7C 07D 211/70 B, 7C 07D 211/72 B, 7C 07D 217/12 B, 7C 07D 217/16 B, 7C 07D 217/18 B, 7C 07D 307/02 B, 7C 07C 255/54 B, 7C 07D 307/79 B, 7C 07D 213/38 B, 7C 07D 215/12 B, 7C 07D 217/14 B |
|
| 17Q | First examination report despatched |
Effective date: 20020305 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20020916 |