EP1060266A4 - Method for identifying mismatch repair glycosylase reactive sites, compound and uses thereof - Google Patents

Method for identifying mismatch repair glycosylase reactive sites, compound and uses thereof

Info

Publication number
EP1060266A4
EP1060266A4 EP99908354A EP99908354A EP1060266A4 EP 1060266 A4 EP1060266 A4 EP 1060266A4 EP 99908354 A EP99908354 A EP 99908354A EP 99908354 A EP99908354 A EP 99908354A EP 1060266 A4 EP1060266 A4 EP 1060266A4
Authority
EP
European Patent Office
Prior art keywords
compound
reactive sites
mismatch repair
identifying
glycosylase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99908354A
Other languages
German (de)
French (fr)
Other versions
EP1060266A1 (en
Inventor
G Mike Makrigiorgos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/224,227 external-priority patent/US6174680B1/en
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Publication of EP1060266A1 publication Critical patent/EP1060266A1/en
Publication of EP1060266A4 publication Critical patent/EP1060266A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
EP99908354A 1998-02-23 1999-02-23 Method for identifying mismatch repair glycosylase reactive sites, compound and uses thereof Withdrawn EP1060266A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7554298P 1998-02-23 1998-02-23
US75542P 1998-02-23
US09/224,227 US6174680B1 (en) 1998-12-30 1998-12-30 Method for identifying mismatch repair glycosylase reactive sites, compounds and uses thereof
US224227 1998-12-30
PCT/US1999/003821 WO1999042622A1 (en) 1998-02-23 1999-02-23 Method for identifying mismatch repair glycosylase reactive sites, compound and uses thereof_____________________________________

Publications (2)

Publication Number Publication Date
EP1060266A1 EP1060266A1 (en) 2000-12-20
EP1060266A4 true EP1060266A4 (en) 2004-09-22

Family

ID=26756994

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99908354A Withdrawn EP1060266A4 (en) 1998-02-23 1999-02-23 Method for identifying mismatch repair glycosylase reactive sites, compound and uses thereof

Country Status (5)

Country Link
EP (1) EP1060266A4 (en)
JP (1) JP2002504352A (en)
AU (1) AU756384B2 (en)
CA (1) CA2321119A1 (en)
WO (1) WO1999042622A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2357601A1 (en) * 1998-12-30 2000-07-06 Dana-Farber Cancer Institute, Inc. Mutation scanning array, and methods of use thereof
FR2798138B1 (en) * 1999-09-03 2004-05-21 Centre Nat Rech Scient CLONING, EXPRESSION AND CHARACTERIZATION OF THE SPG4 GENE RESPONSIBLE FOR THE MOST FREQUENT FORM OF AUTOSOME DOMINANT SPASTIC PARAPLEGIA
US6365355B1 (en) * 2000-03-28 2002-04-02 The Regents Of The University Of California Chimeric proteins for detection and quantitation of DNA mutations, DNA sequence variations, DNA damage and DNA mismatches
AU2001291057A1 (en) * 2000-09-18 2002-04-02 Pioneer Hi-Bred International, Inc. Rice MLH1 ortholog and uses thereof
WO2002030268A2 (en) * 2000-10-13 2002-04-18 Eos Biotechnology, Inc. Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer
US20050089852A1 (en) * 2001-03-14 2005-04-28 Lee Shao C. Method and compositions for evaluating risk of developing type 2 diabetes in people of chinese descent
DE10159904A1 (en) * 2001-12-06 2003-07-03 Adnagen Ag Oligonucleotide arrangement, method for nucleotide detection and device therefor

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122507A2 (en) * 1983-03-23 1984-10-24 Europäische Atomgemeinschaft (Euratom) A process for directly determining apurinic and apyrimidinic sites in DNA
WO1992007951A1 (en) * 1990-10-19 1992-05-14 Yoke Wah Kow Quantitation of aldehyde-containing lesions in nucleic acids
WO1997003210A1 (en) * 1995-07-11 1997-01-30 FORFÁS (trading as BIORESEARCH IRELAND) Glycosylase mediated detection of nucleotide sequences at candidate loci
US5719031A (en) * 1996-08-14 1998-02-17 Molecular Probes, Inc. Dye labeled polymers as reagents for measuring polymer degradation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516663A (en) * 1990-01-26 1996-05-14 Abbott Laboratories Ligase chain reaction with endonuclease IV correction and contamination control
ATE176002T1 (en) * 1990-07-24 1999-02-15 Hoffmann La Roche REDUCING NON-SPECIFIC AMPLIFICATION DURING (IN VITRO) NUCLEIC ACID AMPLIFICATION USING MODIFIED NUCLEIC ACID BASES

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122507A2 (en) * 1983-03-23 1984-10-24 Europäische Atomgemeinschaft (Euratom) A process for directly determining apurinic and apyrimidinic sites in DNA
WO1992007951A1 (en) * 1990-10-19 1992-05-14 Yoke Wah Kow Quantitation of aldehyde-containing lesions in nucleic acids
WO1997003210A1 (en) * 1995-07-11 1997-01-30 FORFÁS (trading as BIORESEARCH IRELAND) Glycosylase mediated detection of nucleotide sequences at candidate loci
US5719031A (en) * 1996-08-14 1998-02-17 Molecular Probes, Inc. Dye labeled polymers as reagents for measuring polymer degradation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BOTURYN D ET AL: "Synthesis of Fluorescent Probes for the Detection of Abasic Sites in DNA", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 53, no. 15, 14 April 1997 (1997-04-14), pages 5485 - 5492, XP004105590, ISSN: 0040-4020 *
See also references of WO9942622A1 *

Also Published As

Publication number Publication date
JP2002504352A (en) 2002-02-12
AU756384B2 (en) 2003-01-09
WO1999042622A1 (en) 1999-08-26
AU2780799A (en) 1999-09-06
CA2321119A1 (en) 1999-08-26
EP1060266A1 (en) 2000-12-20

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Legal Events

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