EP1023271A4 - Process for the synthesis of carbapenem intermediates, and compounds produced - Google Patents

Process for the synthesis of carbapenem intermediates, and compounds produced

Info

Publication number
EP1023271A4
EP1023271A4 EP98950888A EP98950888A EP1023271A4 EP 1023271 A4 EP1023271 A4 EP 1023271A4 EP 98950888 A EP98950888 A EP 98950888A EP 98950888 A EP98950888 A EP 98950888A EP 1023271 A4 EP1023271 A4 EP 1023271A4
Authority
EP
European Patent Office
Prior art keywords
synthesis
compounds produced
carbapenem intermediates
carbapenem
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98950888A
Other languages
German (de)
French (fr)
Other versions
EP1023271A1 (en
Inventor
Mark S Jensen
Chunhua Yang
Nobuyoshi Yasuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806031.2A external-priority patent/GB9806031D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1023271A1 publication Critical patent/EP1023271A1/en
Publication of EP1023271A4 publication Critical patent/EP1023271A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP98950888A 1997-10-07 1998-10-02 Process for the synthesis of carbapenem intermediates, and compounds produced Withdrawn EP1023271A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6123397P 1997-10-07 1997-10-07
US61233P 1997-10-07
GBGB9806031.2A GB9806031D0 (en) 1998-03-20 1998-03-20 Process for the synthesis of carbapenem intermediates, and compounds produced
GB9806031 1998-03-20
PCT/US1998/020830 WO1999018078A1 (en) 1997-10-07 1998-10-02 Process for the synthesis of carbapenem intermediates, and compounds produced

Publications (2)

Publication Number Publication Date
EP1023271A1 EP1023271A1 (en) 2000-08-02
EP1023271A4 true EP1023271A4 (en) 2001-09-12

Family

ID=26313326

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98950888A Withdrawn EP1023271A4 (en) 1997-10-07 1998-10-02 Process for the synthesis of carbapenem intermediates, and compounds produced

Country Status (5)

Country Link
EP (1) EP1023271A4 (en)
JP (1) JP2001519332A (en)
AU (1) AU737447B2 (en)
CA (1) CA2305404A1 (en)
WO (1) WO1999018078A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6069265A (en) * 1998-09-15 2000-05-30 Merck & Co., Inc. Process for the synthesis of 1-aza-5-halo-5-stannabicyclo[3.3.3]undecane carbapenem intermediates

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7602501L (en) * 1975-06-14 1976-12-15 Schering Ag AGENTS WITH BACTERICIDE AND FUNGICIDE EFFECTS

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO9918078A1 *
STILLE J K: "THE PALLADIUM-CATALYZED CROSS-COUPLING REACTIONS OF ORGANOTIN REAGENTS WITH ORGANIC ELECTROPHILES", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION,DE,VERLAG CHEMIE. WEINHEIM, vol. 25, 1986, pages 508 - 524, XP000872970, ISSN: 0570-0833 *

Also Published As

Publication number Publication date
AU9681398A (en) 1999-04-27
CA2305404A1 (en) 1999-04-15
WO1999018078A1 (en) 1999-04-15
AU737447B2 (en) 2001-08-23
JP2001519332A (en) 2001-10-23
EP1023271A1 (en) 2000-08-02

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