EP1017795A4 - Detecting cow, sheep and pig prions in a sample and transgenic animal used for same - Google Patents

Detecting cow, sheep and pig prions in a sample and transgenic animal used for same

Info

Publication number
EP1017795A4
EP1017795A4 EP98945791A EP98945791A EP1017795A4 EP 1017795 A4 EP1017795 A4 EP 1017795A4 EP 98945791 A EP98945791 A EP 98945791A EP 98945791 A EP98945791 A EP 98945791A EP 1017795 A4 EP1017795 A4 EP 1017795A4
Authority
EP
European Patent Office
Prior art keywords
prions
sheep
pig
sample
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98945791A
Other languages
German (de)
French (fr)
Other versions
EP1017795A1 (en
Inventor
Stanley B Prusiner
Michael R Scott
Glenn C Telling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/935,363 external-priority patent/US6008435A/en
Application filed by University of California filed Critical University of California
Publication of EP1017795A1 publication Critical patent/EP1017795A1/en
Publication of EP1017795A4 publication Critical patent/EP1017795A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • A01K2267/0343—Animal model for prion disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP98945791A 1997-09-22 1998-08-28 Detecting cow, sheep and pig prions in a sample and transgenic animal used for same Withdrawn EP1017795A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US935363 1997-09-22
US08/935,363 US6008435A (en) 1994-05-13 1997-09-22 Detecting cow, sheep and human prions in a sample and transgenic mice used for same
PCT/US1998/017879 WO1999015640A1 (en) 1997-09-22 1998-08-28 Detecting cow, sheep and pig prions in a sample and transgenic animal used for same

Publications (2)

Publication Number Publication Date
EP1017795A1 EP1017795A1 (en) 2000-07-12
EP1017795A4 true EP1017795A4 (en) 2002-05-08

Family

ID=25466991

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98945791A Withdrawn EP1017795A4 (en) 1997-09-22 1998-08-28 Detecting cow, sheep and pig prions in a sample and transgenic animal used for same

Country Status (5)

Country Link
EP (1) EP1017795A4 (en)
JP (1) JP2001517775A (en)
AU (1) AU752933B2 (en)
CA (1) CA2302836A1 (en)
WO (1) WO1999015640A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6291899A (en) * 1998-10-09 2000-05-01 Regents Of The University Of California, The Viable prp (prion protein) transgenic animals and methods of use
US20060057636A1 (en) * 2002-08-21 2006-03-16 Peter Heegaard Composite peptide compounds for diagnosis and treatment of diseases caused by prion proteins

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565186A (en) * 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
WO1997004814A1 (en) * 1995-07-31 1997-02-13 The Regents Of The University Of California Detecting prions in a sample and prion preparation and transgenic animal used for same
US5792901A (en) * 1994-05-13 1998-08-11 The Regents Of The University Of California Detecting prions in a sample and prion preparation and transgenic animal used for same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565186A (en) * 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US5763740A (en) * 1994-05-13 1998-06-09 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US5792901A (en) * 1994-05-13 1998-08-11 The Regents Of The University Of California Detecting prions in a sample and prion preparation and transgenic animal used for same
WO1997004814A1 (en) * 1995-07-31 1997-02-13 The Regents Of The University Of California Detecting prions in a sample and prion preparation and transgenic animal used for same

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BUSCHMANN A ET AL: "Generation of transgenic mice expressing the bovine prion protein (PrP).", JOURNAL OF MOLECULAR MEDICINE (BERLIN), vol. 75, no. 7, 1997, XIX Symposium of the International Association for Comparative Research on Leukemia and Related Diseases;Heidelberg, Germany; July 13-18, 1997, pages B176 - B177, XP001061857, ISSN: 0946-2716 *
GABIZON R ET AL: "Of mice and (mad) cows - transgenic mice help to understand prions", TRENDS IN GENETICS, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 13, no. 7, 1 July 1997 (1997-07-01), pages 264 - 269, XP004081447, ISSN: 0168-9525 *
PRUSINER S B: "Molecular biology and pathogenesis of prion diseases", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 21, no. 12, 1 December 1996 (1996-12-01), pages 482 - 487, XP004063036, ISSN: 0968-0004 *
PRUSINER STANLEY B: "Prions", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, no. 23, 10 November 1998 (1998-11-10), pages 13363 - 13383, XP002177728, ISSN: 0027-8424 *
SCOTT MICHAEL R ET AL: "Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 94, no. 26, 23 December 1997 (1997-12-23), pages 14279 - 14284, XP002158407, ISSN: 0027-8424 *
See also references of WO9915640A1 *
TELLING G C ET AL: "INTERACTIONS BETWEEN WILD-TYPE AND MUTANT PRION PROTEINS MODULATE NEURODEGENERATION IN TRANSGENIC MICE", GENES AND DEVELOPMENT, COLD SPRING HARBOR, NY, US, vol. 10, no. 14, 15 July 1996 (1996-07-15), pages 1736 - 1750, XP000675264, ISSN: 0890-9369 *

Also Published As

Publication number Publication date
JP2001517775A (en) 2001-10-09
AU9295398A (en) 1999-04-12
CA2302836A1 (en) 1999-04-01
WO1999015640A1 (en) 1999-04-01
EP1017795A1 (en) 2000-07-12
AU752933B2 (en) 2002-10-03

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