EP1007051A4 - Integrin receptor antagonists - Google Patents

Integrin receptor antagonists

Info

Publication number
EP1007051A4
EP1007051A4 EP98938357A EP98938357A EP1007051A4 EP 1007051 A4 EP1007051 A4 EP 1007051A4 EP 98938357 A EP98938357 A EP 98938357A EP 98938357 A EP98938357 A EP 98938357A EP 1007051 A4 EP1007051 A4 EP 1007051A4
Authority
EP
European Patent Office
Prior art keywords
receptor antagonists
integrin receptor
integrin
antagonists
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98938357A
Other languages
German (de)
French (fr)
Other versions
EP1007051A1 (en
Inventor
Dirk Heerding
James Martin Samanen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP1007051A1 publication Critical patent/EP1007051A1/en
Publication of EP1007051A4 publication Critical patent/EP1007051A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
EP98938357A 1997-08-04 1998-08-04 Integrin receptor antagonists Withdrawn EP1007051A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5470397P 1997-08-04 1997-08-04
US54703P 1997-08-04
US6352697P 1997-10-29 1997-10-29
US63526P 1997-10-29
PCT/US1998/016246 WO1999006049A1 (en) 1997-08-04 1998-08-04 Integrin receptor antagonists

Publications (2)

Publication Number Publication Date
EP1007051A1 EP1007051A1 (en) 2000-06-14
EP1007051A4 true EP1007051A4 (en) 2001-08-29

Family

ID=26733371

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98938357A Withdrawn EP1007051A4 (en) 1997-08-04 1998-08-04 Integrin receptor antagonists

Country Status (5)

Country Link
EP (1) EP1007051A4 (en)
JP (1) JP2001511452A (en)
AU (1) AU8689798A (en)
CA (1) CA2298544A1 (en)
WO (1) WO1999006049A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US6524553B2 (en) 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
US6794518B1 (en) 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
BR9917079A (en) 1998-12-18 2001-10-30 Du Pont Pharm Co Devitronectin receptor antagonist compounds, kit, diagnostic or therapeutic metallopharmaceutical composition, ultrasound contrast agent composition, therapeutic radiopharmaceutical composition, diagnostic pharmaceutical composition, treatment method for rheumatoid arthritis, cancer and darthenosis in a patient, angiogenesis formation method therapy, cancer, new blood vessels, arteriosclerosis, darthenosis, ischemia and myocardial reperfusion injury in a patient
US6511649B1 (en) 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
AU2371400A (en) 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company Vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
PT1140203E (en) * 1998-12-18 2007-08-30 Bristol Myers Squibb Pharma Co Vitronectin receptor antagonist pharmaceuticals
JP2002536370A (en) 1999-02-03 2002-10-29 メルク エンド カムパニー インコーポレーテッド Benzoazepine derivatives as α-V integrin receptor antagonists
CO5180550A1 (en) * 1999-04-19 2002-07-30 Smithkline Beecham Corp FAB I INHIBITORS
JP2003506452A (en) * 1999-08-06 2003-02-18 スミスクライン・ビーチャム・コーポレイション Vitronectin receptor antagonists useful for the treatment of stroke
US6514964B1 (en) 1999-09-27 2003-02-04 Amgen Inc. Fused cycloheptane and fused azacycloheptane compounds and their methods of use
DE10039998A1 (en) * 2000-08-11 2002-02-21 Basf Ag New substituted diareno-azepine derivatives as integrin ligands
DE10027514A1 (en) * 2000-06-06 2002-01-03 Basf Ag Ligands of integrin receptors
DE10028575A1 (en) * 2000-06-14 2002-03-14 Basf Ag integrin
AU2001229580A1 (en) 2000-01-18 2001-08-14 Nuerogen Corporation Substituted imidazoles as selective modulators of bradykinin b2 receptors
JP2004512345A (en) * 2000-11-02 2004-04-22 スミスクライン・ビーチャム・コーポレイション Receptor antagonist-lipid conjugates and delivery vehicles containing the same
CA2444821C (en) 2001-04-24 2012-07-10 Merck Patent Gesellschaft Mit Beschraenkter Haftung Combination therapy using anti-angiogenic agents and tnfa
JP4750360B2 (en) 2001-10-22 2011-08-17 ザ スクリプス リサーチ インスティチュート Antibody targeting compounds
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
WO2007084670A2 (en) 2006-01-18 2007-07-26 Merck Patent Gmbh Specific therapy using integrin ligands for treating cancer
AU2008207095B2 (en) 2007-01-18 2013-08-29 Merck Patent Gmbh Specific therapy and medicament using integrin ligands for treating cancer
US9345739B2 (en) 2007-11-08 2016-05-24 The General Hospital Corporation Methods and compositions for the treatment of proteinuric diseases
ES2428896T3 (en) 2007-11-16 2013-11-12 Ube Industries, Ltd. Benzacepinone compound
JP2012517447A (en) 2009-02-10 2012-08-02 ザ スクリプス リサーチ インスティチュート Chemically programmed vaccination methods
US20120130146A1 (en) 2009-05-25 2012-05-24 Merck Patent Gmbh Continuous administration of cilengitide in cancer treatments
KR20160147007A (en) 2014-05-30 2016-12-21 화이자 인코포레이티드 Carbonitrile derivatives as selective androgen receptor modulators
KR20220115062A (en) 2021-02-09 2022-08-17 (주)오스티오뉴로젠 Pharmaceutical Composition For Treating and Preventing Osteoporosis Comprising Compounds of Chromone Scaffold
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014776A2 (en) * 1992-12-21 1994-07-07 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
WO1996000574A1 (en) * 1994-06-29 1996-01-11 Smithkline Beecham Corporation Vitronectin receptor antagonists
WO1996026190A1 (en) * 1995-02-22 1996-08-29 Smithkline Beecham Corporation Integrin receptor antagonists
WO1997001540A1 (en) * 1995-06-29 1997-01-16 Smithkline Beecham Corporation Integrin receptor antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL318199A1 (en) * 1994-06-29 1997-05-26 Smithkline Beecham Corp Antagonists of vitronectin receptors
EP0869787A4 (en) * 1995-12-29 1999-03-24 Smithkline Beecham Corp Vitronectin receptor antagonists

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014776A2 (en) * 1992-12-21 1994-07-07 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
WO1996000574A1 (en) * 1994-06-29 1996-01-11 Smithkline Beecham Corporation Vitronectin receptor antagonists
WO1996026190A1 (en) * 1995-02-22 1996-08-29 Smithkline Beecham Corporation Integrin receptor antagonists
WO1997001540A1 (en) * 1995-06-29 1997-01-16 Smithkline Beecham Corporation Integrin receptor antagonists

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
RICHARD M. KEENAN ET AL.: "Discovery of potent nonpeptide Vitronectin Receptor (avb3) Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 15, 18 July 1997 (1997-07-18), pages 2289 - 2292, XP002933333 *
See also references of WO9906049A1 *
WILLIAM E. BONDINELLI ET AL.: "Design of a potent and Orally active Nonpeptide platelet Fibrinogen Receptor (GPIIb/IIIa) Antagonist", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 2, no. 9, 1994, pages 897 - 908, XP000196285 *
WILLIAM H. MILLER ET AL.: "Structure-Activity Relationships in 3-oxo-1,4-benzodiazepine-2-acetic Acid GPIIb/IIIA antagonists. The 2-benzazepine series", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 21, 1996, pages 2481 - 2486, XP004135899 *

Also Published As

Publication number Publication date
JP2001511452A (en) 2001-08-14
WO1999006049A1 (en) 1999-02-11
CA2298544A1 (en) 1999-02-11
AU8689798A (en) 1999-02-22
EP1007051A1 (en) 2000-06-14

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Legal Events

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