EP1005624B1 - Procede et dispositif pour refrigerer, en particulier congeler, un materiau - Google Patents

Procede et dispositif pour refrigerer, en particulier congeler, un materiau Download PDF

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Publication number
EP1005624B1
EP1005624B1 EP98949922A EP98949922A EP1005624B1 EP 1005624 B1 EP1005624 B1 EP 1005624B1 EP 98949922 A EP98949922 A EP 98949922A EP 98949922 A EP98949922 A EP 98949922A EP 1005624 B1 EP1005624 B1 EP 1005624B1
Authority
EP
European Patent Office
Prior art keywords
goods
carrier
cooling
cooling fluid
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP98949922A
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German (de)
English (en)
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EP1005624A2 (fr
Inventor
Ingo Heschel
Günter Prof. Dr. Rau
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Individual
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Individual
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Publication of EP1005624A2 publication Critical patent/EP1005624A2/fr
Application granted granted Critical
Publication of EP1005624B1 publication Critical patent/EP1005624B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D31/00—Other cooling or freezing apparatus
    • F25D31/001—Plate freezers
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/10—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air

Definitions

  • the invention relates to a device for cooling, in particular Freezing of refrigerated goods, especially biological material.
  • Devices for freezing biological materials are from the Known cryobiology.
  • HES Hydroxyethyl starch
  • glycerin glycerin
  • the known holders have the disadvantage that the heat transfer from the cooling fluid to the biological material through the holder is hindered.
  • the invention is therefore based on the object of a device Specify generic type with which the cooling of a chilled good can be accelerated.
  • the object of the invention is based on a generic Device solved, which has a holder that the refrigerated goods during the cooling process keeps essentially non-deformable and at least forms a space that is in direct contact between the cooling fluid and the refrigerated goods allows, between the Hait réelle and the Chilled goods guide channels are provided for guiding the cooling fluid.
  • the space preferably runs at least a certain distance of the refrigerated goods.
  • the guide channels for guiding the cooling fluid allow at boiling Cooling media a free convection or a pumping of the cooling medium through the channels.
  • the holder according to the invention is designed so that it in particular bagged liquid blood components in one for cooling favorable shape and still maintain a direct contact between the Cooling fluid and the goods to be refrigerated. On the one hand, this makes the refrigerated goods optimally kept and on the other hand are from the prior art known problems of heat transfer from the refrigerated goods through the bracket avoided on the cooling fluid.
  • the contact surface between the bracket and Chilled goods is smaller than the contact area between the cooling fluid and the chilled goods.
  • This chimney effect is so strong that it is suggested at the inlet and / or to arrange outlet flow-limiting, adjustable devices. This makes it easy to control or To achieve control of the cooling fluid flow.
  • the flow restricting adjustable devices should also be advantageous during the cooling process be adjustable, which means the differences in cooling rates from Edge to the center of the sample can be fixed, otherwise too locally different survival rates.
  • a simple structure of the device is achieved in that the holder keeps the refrigerated goods in the form of a plate. In particular through a cooling the plate-shaped frozen goods on both sides are good cooling rates to achieve.
  • the refrigerated goods can also be kept in the form of a cylinder be and is particularly advantageous is a holder that the refrigerated goods in The shape of a hollow cylinder holds, because this creates a cavity in the refrigerated goods encloses, which can serve as a guide channel for the cooling fluid.
  • a chamber in which the holder can be used and which is preferably heatable.
  • the heatability of the chamber allows the evaporation rate to be set precisely the cooling fluid and thus the convection.
  • the holder itself can also be configured to be heatable.
  • the chamber has an inlet with a cooling fluid pump. This causes a forced flow of the cooling fluid through the chamber and between the refrigerated goods and the holder to achieve the heat transfer improved from refrigerated goods to the cooling fluid.
  • a preferred embodiment provides that the chamber has an overflow and has a separator for liquid cooling fluid. While the liquid Cooling fluid is used for further cooling, the gaseous Share of the cooling fluid either discarded or in a connected one Device liquefied again.
  • a preferred use of the device described is freezing of filled with a liquid, especially blood components Bags. These bags are flexible in shape and need to be as possible be cooled down quickly. Although anti-freeze additives damage of the blood components should be particularly high cooling rates be achieved. This is simple with the device described Way to achieve.
  • a microporous surface is provided on the holder on the side of the cooling fluid.
  • the surface itself can be roughened or an adhesive layer with a microporous surface, such as Leukosilk R , can be applied to the surface. It is particularly advantageous if this microporous layer is attached directly to the bag.
  • the holder can cool down to a temperature below the solidification temperature of the refrigerated goods. But it is the same also possible that the holder a temperature before cooling the goods to be cooled has above the solidification temperature of the refrigerated goods.
  • a device 11 for freezing or cooling a cooling bag 12 shows Figure 1.
  • the bag between two L-shaped plates 13 and 14 clamped, which completely enclose the bag 12.
  • the Plates 13 and 14 are so one above the other by pneumatic cylinders 15, 16 pressed that the cooling bag 12 is held between the plates.
  • the plates 13 and 14 have one on the side facing the bag 12 comb-like structure, which can be seen in Figure 2. This will form at Apply the plates 13, 14 to the cooling bag 12 channels 17 in which Cooling fluid along arrows 18 between the plates and the cooling bag 12 can rise.
  • the plates 13, 14 and the cooling bag 12 are arranged in a chamber 19, which is closed with a lid 20.
  • the plates are from Chamber bottom arranged spaced to underflow of the plate enable.
  • this chamber is via line 21 and the pump 22 liquid nitrogen passed.
  • This liquid nitrogen collects first at the bottom of chamber 19 and then rises in channels 17, whereby it heats up and changes into the vapor phase.
  • the Channels 17 cause a chimney effect that leads to a special one strong flow within the channels.
  • 17 flaps 23, 24 are provided at the entrance of the channels.
  • the nitrogen exiting at the upper end of the channels 17 flows to one Separator 25, which separates liquid from gaseous nitrogen. in this connection the separator 25 comprises a steam outlet opening through which the gaseous nitrogen is discharged.
  • a microporous layer 26, 27 provided the heat transfer from the cooling fluid to the plate and thus improves the heat transfer to the cooler bag.
  • FIG. 3 shows a schematic arrangement of a device according to FIG 1 with heating elements 28 and 29, which are opposite to the cooling bag 30 Sides of the plates 31 and 32 are arranged. This allows the Flow rate in the channels 34, 35 increased and regulated become.
  • Another heating device 36 is in the bottom area of the device provided to also increase the flow of the cooling fluid and regulate. The liquid part of the escaping Cooling fluid is in this variant in a device, not shown collected.
  • FIG 4 shows a further alternative embodiment of the device according to Figure 1 with two heaters 37, 38 for the brackets 43, 44.
  • the refrigerant migrates in the outer area of a container 39 downwards and becomes channels 41 and 42 via a funnel 40 steered in the plates 43 and 44.
  • baffles 45, 46 provided by which liquid refrigerant, which the channels 41, 42 emerges, is returned.
  • a cover 47 with a gas outlet 48 is provided above the diverting plates 45, 46.
  • the Liquid level 49 of the refrigerant is just above the cooling bag and held below the diverter plates 45, 46. This allows the Reduce consumption of liquid nitrogen.
  • the lower one can also be used in the exemplary embodiments according to FIGS Entrance of the channels can be regulated by flaps.
  • the exemplary embodiments according to FIGS. 1, 2, 3 and 4 can on the one hand are operated so that the refrigerated goods and the container or the plates initially kept above the solidification temperature of the refrigerated goods become.
  • the container or the plates can already be pre-cooled be and only the refrigerated goods are kept above the solidification temperature before it is given to the device.

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (16)

  1. Dispositif (11) pour réfrigérer, en particulier congeler, un matériau (12), en particulier un matériau biologique, avec un support (13, 14), le support (13, 14) maintenant le matériau (12) globalement indéformable pendant le processus de réfrigération et formant au moins un espace qui permet un contact direct entre un fluide de réfrigération et le matériau (12), caractérisé en ce qu'entre le support (13, 14) et le matériau (12), des canaux de guidage (17) sont prévus pour canaliser le fluide de réfrigération.
  2. Dispositif (11) selon la revendication 1, caractérisé en ce que la surface de contact entre le support (13, 14) et le matériau (12) est inférieure à la surface de contact entre le fluide de réfrigération et le matériau (12).
  3. Dispositif (11) selon la revendication 1 ou 2, caractérisé en ce que l'entrée des canaux de guidage (17) est disposée plus bas que leur sortie.
  4. Dispositif (11) selon une des revendications précédentes, caractérisé en ce qu'à l'entrée et/ou à la sortie, des systèmes réglables de limitation de débit (23, 24) sont disposés.
  5. Dispositif (11) selon une des revendications précédentes, caractérisé en ce que le support (13, 14) maintient le matériau (12) sous la forme d'une plaque.
  6. Dispositif (11) selon une des revendications précédentes, caractérisé en ce que le support (13, 14) maintient le matériau (12) sous la forme d'un cylindre ou d'un cylindre creux.
  7. Dispositif (11) selon une des revendications précédentes, caractérisé en ce qu'un compartiment (19), dans lequel le support (13, 14) peut être inséré et qui peut de préférence être chauffé, est prévu.
  8. Dispositif (11) selon la revendication 7, caractérisé en ce que le compartiment (19) présente un accès (21) avec une pompe à fluide réfrigérant (22).
  9. Dispositif (11) selon une des revendications 7 ou 8, caractérisé en ce que le compartiment (19) présente un passage et un séparateur (25) pour du fluide réfrigérant liquide.
  10. Utilisation du dispositif (11) selon une des revendications 1 à 9 pour la congélation de poches (12) remplies d'un liquide, en particulier des composés sanguins.
  11. Utilisation du dispositif (11) selon la revendication 10, caractérisé en ce que les poches (12) présentent une surface micro-poreuse.
  12. Utilisation du dispositif (11) selon une des revendications 10 ou 11, dans laquelle le support (13, 14) est pressé globalement avec une pression constante sur le matériau (12).
  13. Dispositif (11) selon une des revendications 1 à 9, dans lequel le support (13, 14) présente, du côté du fluide réfrigérant, une surface micro-poreuse (26, 27).
  14. Dispositif (11) selon une des revendications 1 à 9, dans lequel des systèmes pneumatiques ou hydrauliques pour presser le support (13, 14) sur le matériau (12) sont prévus.
  15. Utilisation du dispositif (11) selon une des revendications 10 à 12, dans laquelle le support (13, 14) présente, avant la réfrigération du matériau (12), une température inférieure à la température de solidification du matériau (12).
  16. Utilisation du dispositif (11) selon une des revendications 10 à 12, dans laquelle le support (13, 14) présente, avant la réfrigération du matériau (12), une température supérieure à la température de solidification du matériau (12).
EP98949922A 1997-08-21 1998-08-20 Procede et dispositif pour refrigerer, en particulier congeler, un materiau Expired - Lifetime EP1005624B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19736372 1997-08-21
DE19736372A DE19736372A1 (de) 1997-08-21 1997-08-21 Verfahren und Vorrichtung zum Kühlen, insbesondere Gefrieren eines Kühlgutes
PCT/DE1998/002427 WO1999010693A2 (fr) 1997-08-21 1998-08-20 Procede et dispositif pour refrigerer, en particulier congeler, un materiau

Publications (2)

Publication Number Publication Date
EP1005624A2 EP1005624A2 (fr) 2000-06-07
EP1005624B1 true EP1005624B1 (fr) 2002-05-08

Family

ID=7839714

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98949922A Expired - Lifetime EP1005624B1 (fr) 1997-08-21 1998-08-20 Procede et dispositif pour refrigerer, en particulier congeler, un materiau

Country Status (5)

Country Link
US (1) US6393860B1 (fr)
EP (1) EP1005624B1 (fr)
AU (1) AU9620298A (fr)
DE (3) DE19736372A1 (fr)
WO (1) WO1999010693A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6698213B2 (en) 2001-05-22 2004-03-02 Integrated Biosystems, Inc. Systems and methods for freezing and storing biopharmaceutical material
US6945056B2 (en) * 2001-11-01 2005-09-20 Integrated Biosystems, Inc. Systems and methods for freezing, mixing and thawing biopharmaceutical material
US7104074B2 (en) * 2001-11-01 2006-09-12 Integrated Biosystems, Inc. Systems and methods for freezing, storing, transporting and thawing biopharmaceutical material
DE60325110D1 (de) * 2002-09-23 2009-01-15 Sartorius Stedim Systems Inc Verfahren und Vorrichtung zum Einfrieren, Lagern, Befördern und Auftauen von biopharmazeutischem Material
CA2509037A1 (fr) * 2002-12-13 2004-07-01 Integrated Biosystems, Inc. Systeme de congelation/decongelation miniature pour produits biopharmaceutiques et biologiques
EP2012585B1 (fr) * 2006-03-06 2016-11-02 Sartorius Stedim North America Inc. Systèmes et procédés utilisés pour congeler, stocker et décongeler des matières biopharmaceutiques
US20090094995A1 (en) * 2006-06-15 2009-04-16 Air Liquide Industrial U.S. Lp System and method for processing food products with fluid recirculation and chilling
US8894894B2 (en) * 2006-06-15 2014-11-25 Air Liquide Industrial U.S. Lp Fluid recirculation system for localized temperature control and chilling of compressed articles
EP3761001A1 (fr) * 2011-05-18 2021-01-06 Biocision, LLC Dispositif de congélation de cellule passive assisté par ventilation
CA3011150A1 (fr) * 2017-08-09 2019-02-09 Carsoe A/S Installation de congelation
US11116206B2 (en) 2018-10-01 2021-09-14 Cook Medical Technologies Llc Cryocontainer

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US3074247A (en) * 1960-04-25 1963-01-22 Texstar Corp Methods and apparatus for use in freezing packaged products
US4018911A (en) 1975-11-10 1977-04-19 The United States Of America As Represented By The Secretary Of The Navy Method for large volume freezing and thawing of packed erythrocytes
US4251995A (en) * 1979-04-25 1981-02-24 Hedbergska Stiftelsen Method of freezing human blood platelets in glycerol-glucose using a statically controlled cooling rate device
DE3142521A1 (de) * 1981-10-27 1983-07-21 Forschungsgesellschaft für Biomedizinische Technik, 5100 Aachen "verfahren und vorrichtung zum definierten abkuehlen plattenfoermiger koerper durch waermeabgabe an siedende kaeltemittel"
JPS6056B2 (ja) * 1983-01-14 1985-01-05 株式会社 ほくさん 受精卵、精子等の凍結装置
CH672834A5 (fr) * 1987-01-19 1989-12-29 Agrogen Stiftung
FR2632391A1 (fr) * 1988-06-07 1989-12-08 Trapani Sauveur Dispositif de congelation rapide de poches de plasma et produits sanguins analogues
US4817397A (en) * 1988-06-21 1989-04-04 Grischenko Valentin I Device for refrigeration and freezing of biological objects
GB8902791D0 (en) 1989-02-08 1989-03-30 Secr Defence A method of freezing blood
US5168712A (en) * 1990-03-19 1992-12-08 Instacool Inc. Of North America Rapid cooling through a thin flexible membrane
US5103651A (en) * 1990-08-31 1992-04-14 Instacool Inc Of North America Plasma storage freezer and thermal transport device
JPH04211351A (ja) * 1991-01-23 1992-08-03 Mitsubishi Kasei Eng Co 回転円筒型処理装置
DE4206705A1 (de) * 1992-03-04 1993-09-09 Blutspendedienst Dt Rote Kreuz Vorrichtung zum eingefrieren von blutplasma in plastikbeuteln
DE4437091C2 (de) 1994-10-17 2003-07-03 Andreas Sputtek Friercontainer
CA2146098A1 (fr) * 1995-01-12 1996-07-13 Ray V. Rajotte Preservation cryogenique en vrac de substances biologiques et applications pour la cryopreservation et l'encapsulage de ces substances
DE19619152A1 (de) * 1996-05-11 1997-11-27 Bernd Dipl Ing Mingers Gefriereinrichtung

Also Published As

Publication number Publication date
EP1005624A2 (fr) 2000-06-07
US6393860B1 (en) 2002-05-28
DE59804073D1 (de) 2002-06-13
AU9620298A (en) 1999-03-16
WO1999010693A2 (fr) 1999-03-04
DE19736372A1 (de) 1999-02-25
DE19881222D2 (de) 2000-10-26
WO1999010693A3 (fr) 1999-05-27

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