EP0853867B1 - Method for sweeping charged particles out of an isochronous cyclotron, and device therefor - Google Patents
Method for sweeping charged particles out of an isochronous cyclotron, and device therefor Download PDFInfo
- Publication number
- EP0853867B1 EP0853867B1 EP96931694A EP96931694A EP0853867B1 EP 0853867 B1 EP0853867 B1 EP 0853867B1 EP 96931694 A EP96931694 A EP 96931694A EP 96931694 A EP96931694 A EP 96931694A EP 0853867 B1 EP0853867 B1 EP 0853867B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- cyclotron
- hills
- air gap
- radius
- sectors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H13/00—Magnetic resonance accelerators; Cyclotrons
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H7/00—Details of devices of the types covered by groups H05H9/00, H05H11/00, H05H13/00
- H05H7/10—Arrangements for ejecting particles from orbits
Definitions
- the present invention relates to a method for extracting charged particles from a cyclotron isochronous in which the particle beam is focused by sectors.
- the present invention also relates to said isochronous cyclotron applying this method of extraction of charged particles.
- the present invention also relates to compact isochronous cyclotrons than focused cyclotrons by sectors. Likewise, the present invention relates to isochronous cyclotrons known as superconductive or not superconductors.
- Cyclotrons are particle accelerators used in particular for the production of isotopes radioactive. These cyclotrons usually consist of two separate main sets, consisting on the one hand by the electromagnet and on the other hand by the high resonator frequency.
- the electromagnet guides the particles loaded on a trajectory presenting approximately a spiral of increasing radius around the acceleration.
- the poles of electromagnets are divided into sectors alternately presenting a reduced air gap and a larger air gap.
- Variation azimuth of the resulting magnetic field has the effect ensure the vertical and horizontal focus of the beam during acceleration.
- isochronous cyclotrons it is advisable to distinguish the compact type cyclotrons, which are energized by at least one main circular coil, and the so-called separate sector cyclotrons, where the structure magnetic is divided into completely separate units autonomous.
- the second set consists of the electrodes accelerators, frequently called “gods" for reasons historical.
- a voltage is thus applied to the electrodes alternative of several tens of kilovolts at the frequency of rotation of the particles in the magnet, or alternatively at a frequency which is an exact multiple of the frequency of rotation of the particles in the magnet. This has the effect to accelerate the particles of the rotating beam in the cyclotron.
- This operation is considered by those skilled in the art as the most difficult step in producing a particle beam accelerated by a cyclotron.
- This operation consists in bringing the beam from the part from the magnetic field where it is accelerated to where the magnetic field can no longer hold the beam. In this case, the beam is free to escape the action of the field and is extracted from the cyclotron.
- cyclotrons accelerating positive particles produce higher beam current intensities, and increase the reliability of the system, and while allowing strong reduction in size and weight of the machine.
- Document US-A-0324379 relates to a cyclotron type device intended to accelerate particles which has magnetic means being essentially independent of the azimuth angle. This means that it is a non-isochronous cyclotron.
- the cyclotron described has beam extraction means which consist of “regenerators” and “compressors”, which allow, in disturbing the magnetic field, to obtain an extraction of the beam of particles.
- the present invention aims to propose a method for extracting charged particles from a cyclotron isochronous avoiding the use of devices extraction as described above.
- An additional aim of the present invention is to therefore to propose an isochronous cyclotron which is of simpler and more economical design than those usually used.
- the present invention also aims to increase the extraction efficiency of the particle beam, and particularly in the case of extraction of positive particles.
- the present invention relates to a method for extracting charged particles from a cyclotron isochronous comprising an electromagnet constituting the circuit magnetic which includes a number of pairs of sectors called “hills” where the air gap is reduced, separated by spaces in the form of sectors called “valleys” where the air gap is larger; this method being characterized by the fact that a cyclotron is produced isochronous with a magnet gap between the hills including the dimensions are chosen so that the minimum value of this air gap in the vicinity of the maximum radius between the hills be less than twenty times the gain in radius by round of particles accelerated by the cyclotron at this radius.
- the air gap that the magnet is in generally between 5 and 20 cm, while the gain in radius per revolution is approximately 1 mm. In this case, the report of the air gap in radius gain per turn is greater than 50.
- the magnetic field decreases very abruptly near the limit of the magnet pole, so that the point of self-extraction is reached before the phase shift of the particles relative to the accelerating voltage does not reach 90 degrees. In this way, the particles automatically exit the magnetic field without intervention of any device extraction.
- the extraction of particles is concentrated on a sector thanks to a dissymmetry deliberately brought to the shape or magnetic field of said sector.
- the angle of one of the sectors is reduced at the polar radius to allow movement of the orbits and thus get the extraction of the whole beam on this side, so, for example, to be able to irradiate a large volume target.
- a particular distribution is carried out of the particle beam so as to simultaneously irradiate several targets mounted side by side on the trajectory of the beam.
- the present invention advantageously makes it possible to be used for proton therapy or the production of radioisotopes, and more particularly of radioisotopes intended to positron emission tomography (PET).
- PET positron emission tomography
- the profile of the magnetic field in an isochronous cyclotron is such that the frequency of rotation of the particles must be constant and independent of their energy. To compensate for the relativistic increase in mass of the particles, the magnetic field must therefore increase with the radius to ensure this condition of isochronism.
- Figure 1 illustrates the variation of the field in function of the radius in a classical isochronous cyclotron.
- Figure 2 illustrates the variation of the field in function of the radius in an isochronous cyclotron using the extraction method according to the present invention.
- An isochronous cyclotron as used in the method of extracting charged particles according to the present invention is shown schematically in the figures 3 and 4.
- This cyclotron is a compact isochronous cyclotron intended for the acceleration of positive particles, and more especially protons.
- the coils 6 are essentially shaped circular, and are located in the annular space left between sectors 3 or 3 'and flow returns 5.
- the central duct is intended to receive at least part of the source of particles 7 to be accelerated. These particles are injected into the center of the device by means known per se.
- the magnet For an isochronous cyclotron accelerating a beam of protons up to an energy of 11 MeV, the magnet is drawn, according to the present invention, with an air gap of 10 mm for a magnetic field of 2 teslas on the sectors magnetic 3 and 3 '.
- the accelerating voltage is 80 kilovolts so as to obtain a radius gain of 1.5 mm at maximum radius.
- one reduces the angle of one of the sectors at the polar radius so as to allow us to move the orbits and obtain the extraction of the whole beam on this side (see figure 4).
- the extracted particle beam is then axially focused and radially defocused.
- this beam profile for simultaneous irradiation of four targets located between the two coils 6 mounted side by side on the beam path.
Abstract
Description
La présente invention se rapporte à une méthode d'extraction de particules chargées hors d'un cyclotron isochrone dans lequel le faisceau de particules est focalisé par secteurs.The present invention relates to a method for extracting charged particles from a cyclotron isochronous in which the particle beam is focused by sectors.
La présente invention se rapporte également audit cyclotron isochrone appliquant cette méthode d'extraction de particules chargées.The present invention also relates to said isochronous cyclotron applying this method of extraction of charged particles.
La présente invention se rapporte aussi bien aux cyclotrons isochrones compacts qu'aux cyclotrons focalisés par secteurs. De même, la présente invention se rapporte aux cyclotrons isochrones dits supraconducteurs ou non supraconducteurs.The present invention also relates to compact isochronous cyclotrons than focused cyclotrons by sectors. Likewise, the present invention relates to isochronous cyclotrons known as superconductive or not superconductors.
Les cyclotrons sont des accélérateurs de particules utilisés en particulier pour la production d'isotopes radioactifs. Ces cyclotrons se composent habituellement de deux ensembles principaux distincts, constitués d'une part par l'électro-aimant et d'autre part par le résonateur haute fréquence.Cyclotrons are particle accelerators used in particular for the production of isotopes radioactive. These cyclotrons usually consist of two separate main sets, consisting on the one hand by the electromagnet and on the other hand by the high resonator frequency.
L'électro-aimant assure le guidage des particules chargées sur une trajectoire présentant approximativement une spirale de rayon croissant autour de l'accélération. Dans les cyclotrons modernes de type isochrone, les pôles d'électroaimants sont divisés en secteurs présentant alternativement un entrefer réduit et un entrefer plus grand. La variation azimutale du champ magnétique qui en résulte a pour effet d'assurer la focalisation verticale et horizontale du faisceau au cours de l'accélération.The electromagnet guides the particles loaded on a trajectory presenting approximately a spiral of increasing radius around the acceleration. In the modern isochronous cyclotrons, the poles of electromagnets are divided into sectors alternately presenting a reduced air gap and a larger air gap. Variation azimuth of the resulting magnetic field has the effect ensure the vertical and horizontal focus of the beam during acceleration.
Parmi les cyclotrons isochrones, il convient de distinguer les cyclotrons de type compact, qui sont énergétisés par au moins une bobine circulaire principale, et les cyclotrons dits à secteurs séparés, où la structure magnétique est divisée en unités séparées entièrement autonomes.Among the isochronous cyclotrons, it is advisable to distinguish the compact type cyclotrons, which are energized by at least one main circular coil, and the so-called separate sector cyclotrons, where the structure magnetic is divided into completely separate units autonomous.
Le second ensemble est constitué par les électrodes accélératrices, appelées fréquemment "dées" pour des raisons historiques. On applique ainsi aux électrodes une tension alternative de plusieurs dizaines de kilovolts à la fréquence de rotation des particules dans l'aimant, ou alternativement à une fréquence qui est un multiple exacte de la fréquence de rotation des particules dans l'aimant. Ceci a pour effet d'accélérer les particules du faisceau tournant dans le cyclotron.The second set consists of the electrodes accelerators, frequently called "gods" for reasons historical. A voltage is thus applied to the electrodes alternative of several tens of kilovolts at the frequency of rotation of the particles in the magnet, or alternatively at a frequency which is an exact multiple of the frequency of rotation of the particles in the magnet. This has the effect to accelerate the particles of the rotating beam in the cyclotron.
Pour de nombreuses applications utilisant un cyclotron, il est nécessaire d'extraire le faisceau de particules accélérées hors du cyclotron, et de le guider jusqu'à une cible où on souhaite l'utiliser. Cette opération d'extraction du faisceau est considérée par l'homme de l'art comme l'étape la plus difficile dans la production d'un faisceau de particules accélérées au moyen d'un cyclotron. Cette opération consiste à amener le faisceau de la partie du champ magnétique où il est accéléré jusqu'à l'endroit où le champ magnétique ne parvient plus à retenir le faisceau. Dans ce cas, le faisceau est libre d'échapper à l'action du champ et est extrait hors du cyclotron.For many applications using a cyclotron, it is necessary to extract the beam from particles accelerated out of the cyclotron, and to guide it to a target where you want to use it. This operation beam extraction is considered by those skilled in the art as the most difficult step in producing a particle beam accelerated by a cyclotron. This operation consists in bringing the beam from the part from the magnetic field where it is accelerated to where the magnetic field can no longer hold the beam. In this case, the beam is free to escape the action of the field and is extracted from the cyclotron.
Dans le cas de cyclotrons accélérant des particules chargées positivement, on connaít l'utilisation d'un déflecteur électrostatique dont le rôle est de tirer les particules hors du champ magnétique comme dispositif d'extraction. Pour obtenir un tel effet, il est nécessaire d'interposer sur le chemin des particules une électrode appelée le septum, qui interceptera une partie de ces particules. De ce fait, le rendement d'extraction est relativement limité, et la perte en particules dans le septum contribuera notamment à rendre le cyclotron fortement radioactif.In the case of cyclotrons accelerating particles positively charged, we know the use of a electrostatic deflector whose role is to draw the particles outside the magnetic field as a device extraction. To achieve such an effect, it is necessary to interpose on the particle path an electrode called the septum, which will intercept some of these particles. Therefore, the extraction yield is relatively limited, and particle loss in the septum will notably contribute to making the cyclotron strongly radioactive.
Il est également connu d'extraire des particules chargées négativement en effectuant une conversion des ions négatifs en ions positifs en faisant passer ceux-ci à travers une feuille qui a pour fonction de dépouiller les ions négatifs de leurs électrons. Cette technique permet des rendements d'extraction proches de 100% et permet également l'utilisation d'un dispositif nettement moins complexe que celui décrit précédemment. Néanmoins, l'accélération des particules négatives présente quant à elle des difficultés importantes. Le principal inconvénient réside dans le fait que les ions négatifs sont fragiles, et sont de ce fait facilement dissociés par des molécules de gaz résiduelles ou par des champs magnétiques excessifs traversés à haute énergie et présents dans le cyclotron. La transmission du faisceau dans l'accélérateur est donc limitée, ce qui contribue aussi à l'activation de ce dernier.It is also known to extract particles negatively charged by converting ions negatives into positive ions by passing them through a sheet which has the function to strip the ions negatives of their electrons. This technique allows extraction yields close to 100% and also allows using a device that is significantly less complex than the one described above. However, the acceleration of negative particles presents difficulties important. The main drawback is that that the negative ions are fragile, and are therefore easily dissociated by residual gas molecules or by excessive magnetic fields crossed at high energy and present in the cyclotron. The transmission of beam in the accelerator is therefore limited, which also contributes to the activation of the latter.
A l'opposé, les cyclotrons accélérant des particules positives permettent de produire de plus hautes intensités de courant de faisceaux, et augmentent la fiabilité du système, et tout en permettant une forte réduction de la taille et du poids de la machine.In contrast, cyclotrons accelerating positive particles produce higher beam current intensities, and increase the reliability of the system, and while allowing strong reduction in size and weight of the machine.
Il est également connu par le document "The review of Scientist Instruments, 27 (1956), n° 7" et par le document "Nuclear Instruments and Methods 18, 19 (1962), pp. 41-45" de J. Reginald Richardson, une technique selon laquelle le faisceau de particules aurait pu être extrait du cyclotron sans l'utilisation d'un dispositif d'extraction. Les conditions requises pour obtenir cette auto-extraction sont des conditions particulières de résonnance du mouvement des particules dans le champ magnétique.It is also known by the document "The review of Scientist Instruments, 27 (1956), n ° 7 "and by the document "Nuclear Instruments and Methods 18, 19 (1962), pp. 41-45" by J. Reginald Richardson, a technique whereby the particle beam could have been extracted from the cyclotron without the use of an extraction device. The requirements for this self-extraction are special conditions for resonating the movement of particles in the magnetic field.
Néanmoins, cette méthode décrite est particulièrement difficile à réaliser, et aurait donné un faisceau dont les qualités optiques étaient tellement mauvaises qu'en pratique, elle n'a jamais été appliquée.However, this described method is particularly difficult to achieve, and would have given a beam whose optical qualities were so bad that in practice it has never been applied.
Le document US-A-0324379 se rapporte à un dispositif du type cyclotron destiné à accélérer des particules qui possède des moyens magnétiques étant essentiellement indépendants de l'angle azimutal. Ceci signifie qu'il s'agit d'un cyclotron non isochrone. En outre, il convient de noter que le cyclotron décrit possède des moyens d'extraction du faisceau qui sont constitués par des "regénérateurs" et des "compresseurs", qui permettent, en perturbant le champ magnétique, d'obtenir une extraction du faisceau de particules.Document US-A-0324379 relates to a cyclotron type device intended to accelerate particles which has magnetic means being essentially independent of the azimuth angle. This means that it is a non-isochronous cyclotron. In addition, it should be noted that the cyclotron described has beam extraction means which consist of "regenerators" and "compressors", which allow, in disturbing the magnetic field, to obtain an extraction of the beam of particles.
Le document WO-93/10651 au nom de la Demanderesse décrit un cyclotron isochrone compact présentant un entrefer localisé entre deux collines de forme essentiellement elliptique et tendant à se refermer complètement à l'extrémité radiale des collines sur le plan médian. Le dispositif décrit dans ce document comprend également des moyens classiques d'extraction du faisceau qui sont un déflecteur électrostatique dans le présent cas.Document WO-93/10651 in the name of the Applicant describes a compact isochronous cyclotron with an air gap located between two basically shaped hills elliptical and tending to close completely at the radial end of the hills on the median plane. The device described in this document also includes conventional means of beam extraction which are a electrostatic deflector in this case.
La présente invention vise à proposer une méthode d'extraction de particules chargées hors d'un cyclotron isochrone en évitant l'utilisation de dispositifs d'extraction tels que décrits précédemment.The present invention aims to propose a method for extracting charged particles from a cyclotron isochronous avoiding the use of devices extraction as described above.
Un but complémentaire de la présente invention vise de ce fait à proposer un cyclotron isochrone qui soit de conception plus simple et plus économique que ceux habituellement utilisés.An additional aim of the present invention is to therefore to propose an isochronous cyclotron which is of simpler and more economical design than those usually used.
La présente invention vise également à augmenter le rendement d'extraction du faisceau de particules, et en particulier dans le cas d'extraction de particules positives.The present invention also aims to increase the extraction efficiency of the particle beam, and particularly in the case of extraction of positive particles.
La présente invention se rapporte à une méthode d'extraction de particules chargées hors d'un cyclotron isochrone comportant un électro-aimant constituant le circuit magnétique qui inclut un certain nombre de paires de secteurs appelées "collines" où l'entrefer est réduit, séparées par des espaces en forme de secteurs appelés "vallées" où l'entrefer est de dimension plus grande; cette méthode étant caractérisée par le fait que l'on réalise un cyclotron isochrone avec un entrefer d'aimant entre les collines dont les dimensions sont choisies de sorte que la valeur minimale de cet entrefer au voisinage du rayon maximal entre les collines soit inférieure à vingt fois le gain en rayon par tour des particules accélérées par le cyclotron à ce rayon.The present invention relates to a method for extracting charged particles from a cyclotron isochronous comprising an electromagnet constituting the circuit magnetic which includes a number of pairs of sectors called "hills" where the air gap is reduced, separated by spaces in the form of sectors called "valleys" where the air gap is larger; this method being characterized by the fact that a cyclotron is produced isochronous with a magnet gap between the hills including the dimensions are chosen so that the minimum value of this air gap in the vicinity of the maximum radius between the hills be less than twenty times the gain in radius by round of particles accelerated by the cyclotron at this radius.
Selon cette configuration particulière, on observera que les ions peuvent être extraits de l'influence du champ magnétique sans l'aide d'aucun dispositif d'extraction.According to this particular configuration, we will observe that the ions can be extracted from the influence of the magnetic field without the help of any device extraction.
Il convient de noter que pour des cyclotrons isochrones de l'état de l'art, l'entrefer ce l'aimant est en général compris entre 5 et 20 cm, alors que le gain en rayon par tour est d'environ 1 mm. Dans ce cas, le rapport de l'entrefer au gain en rayon par tour est supérieur à 50.It should be noted that for cyclotrons isochronous of the state of the art, the air gap that the magnet is in generally between 5 and 20 cm, while the gain in radius per revolution is approximately 1 mm. In this case, the report of the air gap in radius gain per turn is greater than 50.
On observe qu'en appliquant la caractéristique principale de la présente invention, le champ magnétique diminue de façon très brutale au voisinage de la limite du pôle de l'aimant, de telle sorte que le point d'auto-extraction est atteint avant que le déphasage des particules par rapport à la tension accélératrice n'atteigne 90 degrés. De cette manière, les particules sortent automatiquement du champ magnétique sans intervention d'aucun dispositif d'extraction.We observe that by applying the characteristic principal of the present invention, the magnetic field decreases very abruptly near the limit of the magnet pole, so that the point of self-extraction is reached before the phase shift of the particles relative to the accelerating voltage does not reach 90 degrees. In this way, the particles automatically exit the magnetic field without intervention of any device extraction.
Selon une forme d'exécution particulièrement préférée de la présente invention, on peut envisager de dessiner un entrefer présentant un profil elliptique qui a tendance à se refermer à l'extrémité radiale des collines, tel que décrit dans le brevet W093/10651.According to a particular embodiment preferred of the present invention, one can consider draw an air gap with an elliptical profile which has tendency to close at the radial end of the hills, as described in patent W093 / 10651.
Selon une forme d'exécution préférée de la présente invention, l'extraction des particules est concentrée sur un secteur grâce à une dissymétrie apportée délibérément à la forme ou au champ magnétique dudit secteur.According to a preferred embodiment of this invention, the extraction of particles is concentrated on a sector thanks to a dissymmetry deliberately brought to the shape or magnetic field of said sector.
Selon une autre forme d'exécution préférée de la présente invention, on réduit l'angle de l'un des secteurs au niveau du rayon polaire pour permettre de déplacer les orbites et d'obtenir ainsi l'extraction de tout le faisceau de ce côté, de manière, par exemple, à pouvoir irradier une cible de large volume.According to another preferred embodiment of the present invention, the angle of one of the sectors is reduced at the polar radius to allow movement of the orbits and thus get the extraction of the whole beam on this side, so, for example, to be able to irradiate a large volume target.
Selon une autre forme d'exécution préférée de la présente invention, on réalise une distribution particulière du faisceau de particules de manière à irradier simultanément plusieurs cibles montées côte à côte sur la trajectoire du faisceau.According to another preferred embodiment of the present invention, a particular distribution is carried out of the particle beam so as to simultaneously irradiate several targets mounted side by side on the trajectory of the beam.
La présente invention permet avantageusement d'être utilisée pour la protonthérapie ou la production de radio-isotopes, et plus particulièrement de radio-isotopes destinés à la tomographie par émission de positrons (TEP).The present invention advantageously makes it possible to be used for proton therapy or the production of radioisotopes, and more particularly of radioisotopes intended to positron emission tomography (PET).
- Les figures 1 et 2Figures 1 and 2
- représentent les profils magnétiques d'un cyclotron isochrone selon l'état de la technique et d'un cyclotron isochrone utilisant la méthode d'extraction selon la présente invention.represent the magnetic profiles of a isochronous cyclotron according to the state of the technique and an isochronous cyclotron using the extraction method according to the present invention.
- La figure 3Figure 3
- représente de manière schématique une vue éclatée des principaux éléments constituant un cyclotron isochrone.schematically represents a view burst of the main elements constituting a isochronous cyclotron.
- La figure 4Figure 4
- représente une vue en coupe d'un cyclotron isochrone.represents a section view of a cyclotron isochronous.
Le profil du champ magnétique dans un cyclotron
isochrone est tel que la fréquence de rotation des particules
doit être constante et indépendante de leur énergie. Pour
compenser l'augmentation de masse relativiste des particules,
le champ magnétique doit donc augmenter avec le rayon pour
assurer cette condition d'isochronisme. Pour décrire cette
relation, on définit l'indice de champ par la relation
suivante :
Il convient de noter qu'il est impossible de maintenir la condition d'isochronisme au voisinage du rayon maximal du pôle. En effet, à ce moment, le champ cesse d'augmenter avec le rayon. Il a atteint un maximum et commence ensuite à décroítre de plus en plus rapidement.It should be noted that it is impossible to maintain the isochronism condition near the radius maximum of the pole. Indeed, at this moment, the field stops increase with the radius. It has reached a maximum and then begins to decrease more and more quickly.
La figure 1 illustre la variation du champ en fonction du rayon dans un cyclotron isochrone classique. Un déphasage croissant s'installe entre la fréquence de rotation des particules et la fréquence de résonnance des électrodes accélératrices. Lorsque ce déphasage atteint 90 degrés, les particules cessent d'être accélérées et elles ne peuvent dépasser ce rayon.Figure 1 illustrates the variation of the field in function of the radius in a classical isochronous cyclotron. A increasing phase shift between the frequency of rotation of particles and the resonant frequency of the electrodes accelerators. When this phase shift reaches 90 degrees, the particles stop being accelerated and they cannot exceed this radius.
La figure 2 illustre la variation du champ en fonction du rayon dans un cyclotron isochrone utilisant la méthode d'extraction selon la présente invention. En choisissant de manière précise les dimensions de l'entrefer de l'aimant entre les collines, de telle sorte qu'il soit réduit à une valeur de moins de vingt fois le gain en rayon par tour, on observe un profil du champ magnétique tel que représenté à la figure 2.Figure 2 illustrates the variation of the field in function of the radius in an isochronous cyclotron using the extraction method according to the present invention. In choosing precisely the dimensions of the air gap of the magnet between the hills, so that it is reduces the shelf gain to less than twenty times per turn, we observe a profile of the magnetic field such that shown in figure 2.
Dans ce cas, le champ magnétique diminue de façon très brutale au voisinage de la limite du pôle de l'aimant, de telle manière que le point d'auto-extraction défini par l'indice de champ n = -1 est atteint avant que le déphasage des particules par rapport à la tension accélératrice n'atteigne 90 degrés.In this case, the magnetic field decreases so very brutal near the limit of the magnet pole, in such a way that the self-extraction point defined by the field index n = -1 is reached before the phase shift particles with respect to the accelerating voltage does not reach 90 degrees.
A partir de ce moment, les particules sortent automatiquement du champ magnétique sans intervention d'aucun dispositif extracteur.From this moment, the particles come out automatically from the magnetic field without any intervention extractor device.
Un cyclotron isochrone tel qu'il est utilisé dans la méthode d'extraction de particules chargées selon la présente invention est représenté schématiquement aux figures 3 et 4. Ce cyclotron est un cyclotron isochrone compact destiné à l'accélération de particules positives, et plus particulièrement des protons.An isochronous cyclotron as used in the method of extracting charged particles according to the present invention is shown schematically in the figures 3 and 4. This cyclotron is a compact isochronous cyclotron intended for the acceleration of positive particles, and more especially protons.
La structure magnétique 1 du cyclotron se compose d'un certain nombre d'éléments 2, 3, 4 et 5 réalisés en un matériau ferro-magnétique et de bobines 6 réalisées de préférence en un matériau conducteur ou supra-conducteur. La structure ferro-magnétique comporte de manière classique :
- deux plaques de base appelées culasses 2 et 2',
- au moins trois secteurs 3 supérieurs appelés collines et
un même nombre de secteurs inférieurs 3' situés
symétriquement par rapport à un plan de symétrie 10 dit
plan médian aux secteurs supérieurs 3, et qui sont
séparés par
un faible entrefer 8, - entre deux collines consécutives, il existe un espace où l'entrefer est de dimension plus élevée et est qui appelé vallée 4,
- au moins un retour de
flux 5 réunissant de façon rigide la culasse inférieure 2 à la culasse supérieure 2',
- two base plates called
cylinder heads 2 and 2 ', - at least three
upper sectors 3 called hills and the same number of lower sectors 3 'situated symmetrically with respect to a plane ofsymmetry 10 said median plane to theupper sectors 3, and which are separated by asmall air gap 8, - between two consecutive hills, there is a space where the air gap is of higher dimension and which is called valley 4,
- at least one
flow return 5 rigidly joining thelower cylinder head 2 to the upper cylinder head 2 ',
Les bobines 6 sont de forme essentiellement
circulaire, et sont localisées dans l'espace annulaire laissé
entre les secteurs 3 ou 3'et les retours de flux 5.The
Le conduit central est destiné à recevoir au moins
une partie de la source de particules 7 à accélérer. Ces
particules sont injectées au centre de l'appareil par des
moyens connus en soi. The central duct is intended to receive at least
part of the source of
Pour un cyclotron isochrone accélérant un faisceau de protons jusqu'à une énergie de 11 MeV, l'aimant est dessiné, selon la présente invention, avec un entrefer de 10 mm pour un champ magnétique de 2 teslas sur les secteurs magnétiques 3 et 3'. La tension accélératrice est de 80 kilovolts de manière à obtenir un gain en rayon de 1,5 mm au rayon maximal.For an isochronous cyclotron accelerating a beam of protons up to an energy of 11 MeV, the magnet is drawn, according to the present invention, with an air gap of 10 mm for a magnetic field of 2 teslas on the sectors magnetic 3 and 3 '. The accelerating voltage is 80 kilovolts so as to obtain a radius gain of 1.5 mm at maximum radius.
Ce choix inusuel des paramètres permet qu'à l'extrémité radiale des collines, on observe une décroissante extrêmement rapide de l'induction extérieure qui permet d'auto-extraire le faisceau de particules avant la limite d'accélération, ce qui est plus particulièrement représenté à la figure 2.This unusual choice of parameters allows that the radial end of the hills, we observe a decreasing extremely fast external induction which allows to self-extract the particle beam before the limit of acceleration, which is more particularly represented in Figure 2.
Selon une première forme d'exécution préférée, on réduit l'angle d'un des secteurs au niveau du rayon polaire de manière à permettre de déplacer les orbites et d'obtenir l'extraction de tout le faisceau de ce côté (voir figure 4).According to a first preferred embodiment, one reduces the angle of one of the sectors at the polar radius so as to allow us to move the orbits and obtain the extraction of the whole beam on this side (see figure 4).
Le faisceau de particules extrait est alors axialement focalisé et radialement défocalisé.The extracted particle beam is then axially focused and radially defocused.
Selon une autre forme d'exécution préférée, on
utilise ce profil de faisceau pour l'irradiation simultanée
de quatre cibles localisées entre les deux bobines 6 montées
côte à côte sur la trajectoire du faisceau.According to another preferred embodiment,
use this beam profile for simultaneous irradiation
of four targets located between the two
Claims (7)
- Method of extracting a beam of charged particles from an isochronous cyclotron (1) having an electromagnet constituting the magnetic circuit which includes at least a certain number of sectors (3, 3'), referred to as "hills", where the air gap is reduced, these being separated by spaces in the form of sectors (4), referred to as "valleys", where the air gap is of larger size, the extraction method being characterized in that the particle beam is extracted by a particular arrangement of the magnetic field, without resorting to an extraction device, this arrangement being obtained by designing the air gap of the magnet at the hills (3, 3') of the isochronous cyclotron in such a way that the ratio of the dimension of the air gap of the magnet at the hills in the vicinity of the maximum radius to the gain in radius per circuit of the particles accelerated by the cyclotron at this radius is less than 20.
- Isochronous cyclotron in which a particle beam is focused by sectors and which has an electromagnet constituting a magnetic circuit which includes at least a certain number of sectors (3, 3'), referred to as "hills", where an air gap is reduced, these being separated by spaces in the form of sectors (4), referred to as "valleys", where an air gap is of larger size, characterized in that the air gap of the magnet at the hills (3, 3') is designed in such a way that the ratio of the dimension of the air gap of the magnet at the hills in the vicinity of the maximum radius to the gain in radius per circuit of the particles accelerated by the cyclotron at this radius is less than 20.
- Isochronous cyclotron according to Claim 2, characterized in that the profile of the air gap of the magnet at the hills is an elliptical profile tending to close on itself at the radial end of the hills.
- Cyclotron according to Claim 2 or 3, characterized in that at least one sector has a shape or a magnetic field that is asymmetric with respect to the other sectors.
- Cyclotron according to any one of Claims 2 to 4, characterized in that the angle of one of the sectors is reduced at the pole radius.
- Cyclotron according to any one of Claims 2 to 4, characterized in that a particular distribution of the particle beam is produced so as simultaneously to irradiate a plurality of targets mounted side by side on the path of the beam.
- Use of the particle extraction method according to Claim 1 or of the device according to any one of Claims 2 to 6 for proton therapy or for the production of radioisotopes, and in particular for the production of radioisotopes which are intended for positron emission tomography.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE9500832A BE1009669A3 (en) | 1995-10-06 | 1995-10-06 | Method of extraction out of a charged particle isochronous cyclotron and device applying this method. |
BE9500832 | 1995-10-06 | ||
PCT/BE1996/000101 WO1997014279A1 (en) | 1995-10-06 | 1996-09-25 | Method for sweeping charged particles out of an isochronous cyclotron, and device therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0853867A1 EP0853867A1 (en) | 1998-07-22 |
EP0853867B1 true EP0853867B1 (en) | 1999-07-28 |
Family
ID=3889224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96931694A Expired - Lifetime EP0853867B1 (en) | 1995-10-06 | 1996-09-25 | Method for sweeping charged particles out of an isochronous cyclotron, and device therefor |
Country Status (9)
Country | Link |
---|---|
US (1) | US6057655A (en) |
EP (1) | EP0853867B1 (en) |
JP (1) | JP4008030B2 (en) |
AT (1) | ATE182739T1 (en) |
BE (1) | BE1009669A3 (en) |
DE (1) | DE69603497T2 (en) |
ES (1) | ES2135918T3 (en) |
GR (1) | GR3031392T3 (en) |
WO (1) | WO1997014279A1 (en) |
Families Citing this family (138)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE513190C2 (en) * | 1998-09-29 | 2000-07-24 | Gems Pet Systems Ab | Method and system for minimizing magnetic size in a cyclotron |
EP1069809A1 (en) * | 1999-07-13 | 2001-01-17 | Ion Beam Applications S.A. | Isochronous cyclotron and method of extraction of charged particles from such cyclotron |
EP1385362A1 (en) * | 2002-07-22 | 2004-01-28 | Ion Beam Applications S.A. | Cyclotron provided with new particle beam sweeping means |
CN101006541B (en) * | 2003-06-02 | 2010-07-07 | 福克斯·彻斯癌症中心 | High energy polyenergetic ion selection systems, ion beam therapy systems, and ion beam treatment centers |
JP5046928B2 (en) * | 2004-07-21 | 2012-10-10 | メヴィオン・メディカル・システムズ・インコーポレーテッド | Synchrocyclotron and method for generating particle beams |
US9077022B2 (en) * | 2004-10-29 | 2015-07-07 | Medtronic, Inc. | Lithium-ion battery |
WO2007061937A2 (en) | 2005-11-18 | 2007-05-31 | Still River Systems Inc. | Charged particle radiation therapy |
JP2009524201A (en) * | 2006-01-19 | 2009-06-25 | マサチューセッツ・インスティテュート・オブ・テクノロジー | High-field superconducting synchrocyclotron |
US7656258B1 (en) | 2006-01-19 | 2010-02-02 | Massachusetts Institute Of Technology | Magnet structure for particle acceleration |
FR2897398A1 (en) * | 2006-02-14 | 2007-08-17 | Claude Poher | DEVICE THROUGH ACCELERATION OF PARTICLES AND APPLICATIONS OF SAID DEVICE |
US8003964B2 (en) | 2007-10-11 | 2011-08-23 | Still River Systems Incorporated | Applying a particle beam to a patient |
US8581523B2 (en) | 2007-11-30 | 2013-11-12 | Mevion Medical Systems, Inc. | Interrupted particle source |
US8933650B2 (en) | 2007-11-30 | 2015-01-13 | Mevion Medical Systems, Inc. | Matching a resonant frequency of a resonant cavity to a frequency of an input voltage |
US9498649B2 (en) | 2008-05-22 | 2016-11-22 | Vladimir Balakin | Charged particle cancer therapy patient constraint apparatus and method of use thereof |
US9910166B2 (en) | 2008-05-22 | 2018-03-06 | Stephen L. Spotts | Redundant charged particle state determination apparatus and method of use thereof |
US9155911B1 (en) | 2008-05-22 | 2015-10-13 | Vladimir Balakin | Ion source method and apparatus used in conjunction with a charged particle cancer therapy system |
US9737733B2 (en) | 2008-05-22 | 2017-08-22 | W. Davis Lee | Charged particle state determination apparatus and method of use thereof |
CN102119585B (en) | 2008-05-22 | 2016-02-03 | 弗拉迪米尔·叶戈罗维奇·巴拉金 | The method and apparatus of charged particle cancer therapy patient location |
US8378321B2 (en) * | 2008-05-22 | 2013-02-19 | Vladimir Balakin | Charged particle cancer therapy and patient positioning method and apparatus |
US9937362B2 (en) | 2008-05-22 | 2018-04-10 | W. Davis Lee | Dynamic energy control of a charged particle imaging/treatment apparatus and method of use thereof |
US8975600B2 (en) | 2008-05-22 | 2015-03-10 | Vladimir Balakin | Treatment delivery control system and method of operation thereof |
US8896239B2 (en) | 2008-05-22 | 2014-11-25 | Vladimir Yegorovich Balakin | Charged particle beam injection method and apparatus used in conjunction with a charged particle cancer therapy system |
US8378311B2 (en) | 2008-05-22 | 2013-02-19 | Vladimir Balakin | Synchrotron power cycling apparatus and method of use thereof |
US10548551B2 (en) | 2008-05-22 | 2020-02-04 | W. Davis Lee | Depth resolved scintillation detector array imaging apparatus and method of use thereof |
US8519365B2 (en) | 2008-05-22 | 2013-08-27 | Vladimir Balakin | Charged particle cancer therapy imaging method and apparatus |
US8373143B2 (en) * | 2008-05-22 | 2013-02-12 | Vladimir Balakin | Patient immobilization and repositioning method and apparatus used in conjunction with charged particle cancer therapy |
US8624528B2 (en) | 2008-05-22 | 2014-01-07 | Vladimir Balakin | Method and apparatus coordinating synchrotron acceleration periods with patient respiration periods |
US10070831B2 (en) | 2008-05-22 | 2018-09-11 | James P. Bennett | Integrated cancer therapy—imaging apparatus and method of use thereof |
US8089054B2 (en) | 2008-05-22 | 2012-01-03 | Vladimir Balakin | Charged particle beam acceleration and extraction method and apparatus used in conjunction with a charged particle cancer therapy system |
EP2283711B1 (en) * | 2008-05-22 | 2018-07-11 | Vladimir Yegorovich Balakin | Charged particle beam acceleration apparatus as part of a charged particle cancer therapy system |
US8288742B2 (en) * | 2008-05-22 | 2012-10-16 | Vladimir Balakin | Charged particle cancer therapy patient positioning method and apparatus |
US8907309B2 (en) | 2009-04-17 | 2014-12-09 | Stephen L. Spotts | Treatment delivery control system and method of operation thereof |
US8710462B2 (en) | 2008-05-22 | 2014-04-29 | Vladimir Balakin | Charged particle cancer therapy beam path control method and apparatus |
US8368038B2 (en) | 2008-05-22 | 2013-02-05 | Vladimir Balakin | Method and apparatus for intensity control of a charged particle beam extracted from a synchrotron |
US9974978B2 (en) | 2008-05-22 | 2018-05-22 | W. Davis Lee | Scintillation array apparatus and method of use thereof |
US10092776B2 (en) | 2008-05-22 | 2018-10-09 | Susan L. Michaud | Integrated translation/rotation charged particle imaging/treatment apparatus and method of use thereof |
US9095040B2 (en) | 2008-05-22 | 2015-07-28 | Vladimir Balakin | Charged particle beam acceleration and extraction method and apparatus used in conjunction with a charged particle cancer therapy system |
WO2009142550A2 (en) | 2008-05-22 | 2009-11-26 | Vladimir Yegorovich Balakin | Charged particle beam extraction method and apparatus used in conjunction with a charged particle cancer therapy system |
US8969834B2 (en) | 2008-05-22 | 2015-03-03 | Vladimir Balakin | Charged particle therapy patient constraint apparatus and method of use thereof |
US9855444B2 (en) | 2008-05-22 | 2018-01-02 | Scott Penfold | X-ray detector for proton transit detection apparatus and method of use thereof |
US8373146B2 (en) * | 2008-05-22 | 2013-02-12 | Vladimir Balakin | RF accelerator method and apparatus used in conjunction with a charged particle cancer therapy system |
US8487278B2 (en) * | 2008-05-22 | 2013-07-16 | Vladimir Yegorovich Balakin | X-ray method and apparatus used in conjunction with a charged particle cancer therapy system |
US8637833B2 (en) | 2008-05-22 | 2014-01-28 | Vladimir Balakin | Synchrotron power supply apparatus and method of use thereof |
US9744380B2 (en) | 2008-05-22 | 2017-08-29 | Susan L. Michaud | Patient specific beam control assembly of a cancer therapy apparatus and method of use thereof |
US8178859B2 (en) * | 2008-05-22 | 2012-05-15 | Vladimir Balakin | Proton beam positioning verification method and apparatus used in conjunction with a charged particle cancer therapy system |
US10143854B2 (en) | 2008-05-22 | 2018-12-04 | Susan L. Michaud | Dual rotation charged particle imaging / treatment apparatus and method of use thereof |
US9168392B1 (en) | 2008-05-22 | 2015-10-27 | Vladimir Balakin | Charged particle cancer therapy system X-ray apparatus and method of use thereof |
AU2009249863B2 (en) | 2008-05-22 | 2013-12-12 | Vladimir Yegorovich Balakin | Multi-field charged particle cancer therapy method and apparatus |
US9737734B2 (en) | 2008-05-22 | 2017-08-22 | Susan L. Michaud | Charged particle translation slide control apparatus and method of use thereof |
US8598543B2 (en) * | 2008-05-22 | 2013-12-03 | Vladimir Balakin | Multi-axis/multi-field charged particle cancer therapy method and apparatus |
US9177751B2 (en) | 2008-05-22 | 2015-11-03 | Vladimir Balakin | Carbon ion beam injector apparatus and method of use thereof |
US8129694B2 (en) * | 2008-05-22 | 2012-03-06 | Vladimir Balakin | Negative ion beam source vacuum method and apparatus used in conjunction with a charged particle cancer therapy system |
US9782140B2 (en) | 2008-05-22 | 2017-10-10 | Susan L. Michaud | Hybrid charged particle / X-ray-imaging / treatment apparatus and method of use thereof |
US8718231B2 (en) | 2008-05-22 | 2014-05-06 | Vladimir Balakin | X-ray tomography method and apparatus used in conjunction with a charged particle cancer therapy system |
US9044600B2 (en) | 2008-05-22 | 2015-06-02 | Vladimir Balakin | Proton tomography apparatus and method of operation therefor |
US10684380B2 (en) | 2008-05-22 | 2020-06-16 | W. Davis Lee | Multiple scintillation detector array imaging apparatus and method of use thereof |
US9737272B2 (en) | 2008-05-22 | 2017-08-22 | W. Davis Lee | Charged particle cancer therapy beam state determination apparatus and method of use thereof |
US8642978B2 (en) | 2008-05-22 | 2014-02-04 | Vladimir Balakin | Charged particle cancer therapy dose distribution method and apparatus |
US8144832B2 (en) * | 2008-05-22 | 2012-03-27 | Vladimir Balakin | X-ray tomography method and apparatus used in conjunction with a charged particle cancer therapy system |
US7939809B2 (en) | 2008-05-22 | 2011-05-10 | Vladimir Balakin | Charged particle beam extraction method and apparatus used in conjunction with a charged particle cancer therapy system |
US9579525B2 (en) | 2008-05-22 | 2017-02-28 | Vladimir Balakin | Multi-axis charged particle cancer therapy method and apparatus |
US10029122B2 (en) | 2008-05-22 | 2018-07-24 | Susan L. Michaud | Charged particle—patient motion control system apparatus and method of use thereof |
EP2283713B1 (en) * | 2008-05-22 | 2018-03-28 | Vladimir Yegorovich Balakin | Multi-axis charged particle cancer therapy apparatus |
US9981147B2 (en) | 2008-05-22 | 2018-05-29 | W. Davis Lee | Ion beam extraction apparatus and method of use thereof |
WO2009142544A2 (en) * | 2008-05-22 | 2009-11-26 | Vladimir Yegorovich Balakin | Charged particle cancer therapy beam path control method and apparatus |
US8309941B2 (en) | 2008-05-22 | 2012-11-13 | Vladimir Balakin | Charged particle cancer therapy and patient breath monitoring method and apparatus |
US8129699B2 (en) | 2008-05-22 | 2012-03-06 | Vladimir Balakin | Multi-field charged particle cancer therapy method and apparatus coordinated with patient respiration |
US9682254B2 (en) | 2008-05-22 | 2017-06-20 | Vladimir Balakin | Cancer surface searing apparatus and method of use thereof |
US8374314B2 (en) | 2008-05-22 | 2013-02-12 | Vladimir Balakin | Synchronized X-ray / breathing method and apparatus used in conjunction with a charged particle cancer therapy system |
US8569717B2 (en) | 2008-05-22 | 2013-10-29 | Vladimir Balakin | Intensity modulated three-dimensional radiation scanning method and apparatus |
US8093564B2 (en) | 2008-05-22 | 2012-01-10 | Vladimir Balakin | Ion beam focusing lens method and apparatus used in conjunction with a charged particle cancer therapy system |
US9056199B2 (en) | 2008-05-22 | 2015-06-16 | Vladimir Balakin | Charged particle treatment, rapid patient positioning apparatus and method of use thereof |
US8399866B2 (en) | 2008-05-22 | 2013-03-19 | Vladimir Balakin | Charged particle extraction apparatus and method of use thereof |
US8373145B2 (en) * | 2008-05-22 | 2013-02-12 | Vladimir Balakin | Charged particle cancer therapy system magnet control method and apparatus |
US8188688B2 (en) | 2008-05-22 | 2012-05-29 | Vladimir Balakin | Magnetic field control method and apparatus used in conjunction with a charged particle cancer therapy system |
US9616252B2 (en) | 2008-05-22 | 2017-04-11 | Vladimir Balakin | Multi-field cancer therapy apparatus and method of use thereof |
US8198607B2 (en) * | 2008-05-22 | 2012-06-12 | Vladimir Balakin | Tandem accelerator method and apparatus used in conjunction with a charged particle cancer therapy system |
US8436327B2 (en) * | 2008-05-22 | 2013-05-07 | Vladimir Balakin | Multi-field charged particle cancer therapy method and apparatus |
EP2129193A1 (en) | 2008-05-30 | 2009-12-02 | Ion Beam Applications S.A. | A stripping member, a stripping assembly and a method for extracting a particle beam from a cyclotron |
EP2134145A1 (en) * | 2008-06-09 | 2009-12-16 | Ion Beam Applications S.A. | A twin internal ion source for particle beam production with a cyclotron |
US8625739B2 (en) | 2008-07-14 | 2014-01-07 | Vladimir Balakin | Charged particle cancer therapy x-ray method and apparatus |
US8627822B2 (en) * | 2008-07-14 | 2014-01-14 | Vladimir Balakin | Semi-vertical positioning method and apparatus used in conjunction with a charged particle cancer therapy system |
US8229072B2 (en) * | 2008-07-14 | 2012-07-24 | Vladimir Balakin | Elongated lifetime X-ray method and apparatus used in conjunction with a charged particle cancer therapy system |
AU2009341615B2 (en) | 2009-03-04 | 2013-03-28 | Zakrytoe Aktsionernoe Obshchestvo Protom | Multi-field charged particle cancer therapy method and apparatus |
US8153997B2 (en) | 2009-05-05 | 2012-04-10 | General Electric Company | Isotope production system and cyclotron |
US8106570B2 (en) | 2009-05-05 | 2012-01-31 | General Electric Company | Isotope production system and cyclotron having reduced magnetic stray fields |
US8106370B2 (en) * | 2009-05-05 | 2012-01-31 | General Electric Company | Isotope production system and cyclotron having a magnet yoke with a pump acceptance cavity |
US8374306B2 (en) | 2009-06-26 | 2013-02-12 | General Electric Company | Isotope production system with separated shielding |
US10556126B2 (en) | 2010-04-16 | 2020-02-11 | Mark R. Amato | Automated radiation treatment plan development apparatus and method of use thereof |
US10086214B2 (en) | 2010-04-16 | 2018-10-02 | Vladimir Balakin | Integrated tomography—cancer treatment apparatus and method of use thereof |
US10638988B2 (en) | 2010-04-16 | 2020-05-05 | Scott Penfold | Simultaneous/single patient position X-ray and proton imaging apparatus and method of use thereof |
US11648420B2 (en) | 2010-04-16 | 2023-05-16 | Vladimir Balakin | Imaging assisted integrated tomography—cancer treatment apparatus and method of use thereof |
US10751551B2 (en) | 2010-04-16 | 2020-08-25 | James P. Bennett | Integrated imaging-cancer treatment apparatus and method of use thereof |
US10179250B2 (en) | 2010-04-16 | 2019-01-15 | Nick Ruebel | Auto-updated and implemented radiation treatment plan apparatus and method of use thereof |
US9737731B2 (en) | 2010-04-16 | 2017-08-22 | Vladimir Balakin | Synchrotron energy control apparatus and method of use thereof |
US10625097B2 (en) | 2010-04-16 | 2020-04-21 | Jillian Reno | Semi-automated cancer therapy treatment apparatus and method of use thereof |
US10589128B2 (en) | 2010-04-16 | 2020-03-17 | Susan L. Michaud | Treatment beam path verification in a cancer therapy apparatus and method of use thereof |
US10376717B2 (en) | 2010-04-16 | 2019-08-13 | James P. Bennett | Intervening object compensating automated radiation treatment plan development apparatus and method of use thereof |
US10518109B2 (en) | 2010-04-16 | 2019-12-31 | Jillian Reno | Transformable charged particle beam path cancer therapy apparatus and method of use thereof |
US10188877B2 (en) | 2010-04-16 | 2019-01-29 | W. Davis Lee | Fiducial marker/cancer imaging and treatment apparatus and method of use thereof |
US10555710B2 (en) | 2010-04-16 | 2020-02-11 | James P. Bennett | Simultaneous multi-axes imaging apparatus and method of use thereof |
US10349906B2 (en) | 2010-04-16 | 2019-07-16 | James P. Bennett | Multiplexed proton tomography imaging apparatus and method of use thereof |
US9693443B2 (en) | 2010-04-19 | 2017-06-27 | General Electric Company | Self-shielding target for isotope production systems |
BE1019411A4 (en) | 2010-07-09 | 2012-07-03 | Ion Beam Applic Sa | MEANS FOR MODIFYING THE MAGNETIC FIELD PROFILE IN A CYCLOTRON. |
US8653762B2 (en) | 2010-12-23 | 2014-02-18 | General Electric Company | Particle accelerators having electromechanical motors and methods of operating and manufacturing the same |
JP5665721B2 (en) * | 2011-02-28 | 2015-02-04 | 三菱電機株式会社 | Circular accelerator and operation method of circular accelerator |
US8963112B1 (en) | 2011-05-25 | 2015-02-24 | Vladimir Balakin | Charged particle cancer therapy patient positioning method and apparatus |
US9336915B2 (en) | 2011-06-17 | 2016-05-10 | General Electric Company | Target apparatus and isotope production systems and methods using the same |
US8558485B2 (en) | 2011-07-07 | 2013-10-15 | Ionetix Corporation | Compact, cold, superconducting isochronous cyclotron |
CN102624286A (en) * | 2012-03-27 | 2012-08-01 | 上海耀江幕墙工程有限公司 | Solar generating system used for building and adopting micro inverters |
US9894746B2 (en) | 2012-03-30 | 2018-02-13 | General Electric Company | Target windows for isotope systems |
CN105103662B (en) | 2012-09-28 | 2018-04-13 | 梅维昂医疗系统股份有限公司 | magnetic field regenerator |
US10254739B2 (en) | 2012-09-28 | 2019-04-09 | Mevion Medical Systems, Inc. | Coil positioning system |
WO2014052719A2 (en) | 2012-09-28 | 2014-04-03 | Mevion Medical Systems, Inc. | Adjusting energy of a particle beam |
US9545528B2 (en) | 2012-09-28 | 2017-01-17 | Mevion Medical Systems, Inc. | Controlling particle therapy |
JP6121546B2 (en) | 2012-09-28 | 2017-04-26 | メビオン・メディカル・システムズ・インコーポレーテッド | Control system for particle accelerator |
WO2014052718A2 (en) | 2012-09-28 | 2014-04-03 | Mevion Medical Systems, Inc. | Focusing a particle beam |
WO2014052708A2 (en) | 2012-09-28 | 2014-04-03 | Mevion Medical Systems, Inc. | Magnetic shims to alter magnetic fields |
JP6367201B2 (en) | 2012-09-28 | 2018-08-01 | メビオン・メディカル・システムズ・インコーポレーテッド | Control of particle beam intensity |
TWI604868B (en) | 2012-09-28 | 2017-11-11 | 美威高能離子醫療系統公司 | Particle accelerator and proton therapy system |
US8933651B2 (en) | 2012-11-16 | 2015-01-13 | Vladimir Balakin | Charged particle accelerator magnet apparatus and method of use thereof |
US8791656B1 (en) | 2013-05-31 | 2014-07-29 | Mevion Medical Systems, Inc. | Active return system |
US9730308B2 (en) | 2013-06-12 | 2017-08-08 | Mevion Medical Systems, Inc. | Particle accelerator that produces charged particles having variable energies |
WO2015048468A1 (en) | 2013-09-27 | 2015-04-02 | Mevion Medical Systems, Inc. | Particle beam scanning |
US9962560B2 (en) | 2013-12-20 | 2018-05-08 | Mevion Medical Systems, Inc. | Collimator and energy degrader |
US10675487B2 (en) | 2013-12-20 | 2020-06-09 | Mevion Medical Systems, Inc. | Energy degrader enabling high-speed energy switching |
US9661736B2 (en) | 2014-02-20 | 2017-05-23 | Mevion Medical Systems, Inc. | Scanning system for a particle therapy system |
DE102014003536A1 (en) * | 2014-03-13 | 2015-09-17 | Forschungszentrum Jülich GmbH Fachbereich Patente | Superconducting magnetic field stabilizer |
US9950194B2 (en) | 2014-09-09 | 2018-04-24 | Mevion Medical Systems, Inc. | Patient positioning system |
US9961756B2 (en) | 2014-10-07 | 2018-05-01 | General Electric Company | Isotope production target chamber including a cavity formed from a single sheet of metal foil |
US10786689B2 (en) | 2015-11-10 | 2020-09-29 | Mevion Medical Systems, Inc. | Adaptive aperture |
US9907981B2 (en) | 2016-03-07 | 2018-03-06 | Susan L. Michaud | Charged particle translation slide control apparatus and method of use thereof |
US10037863B2 (en) | 2016-05-27 | 2018-07-31 | Mark R. Amato | Continuous ion beam kinetic energy dissipater apparatus and method of use thereof |
JP7059245B2 (en) | 2016-07-08 | 2022-04-25 | メビオン・メディカル・システムズ・インコーポレーテッド | Decide on a treatment plan |
CN106163073B (en) * | 2016-07-29 | 2018-11-30 | 中国原子能科学研究院 | A kind of line outbound course of middle energy superconduction bevatron |
US11103730B2 (en) | 2017-02-23 | 2021-08-31 | Mevion Medical Systems, Inc. | Automated treatment in particle therapy |
US10653892B2 (en) | 2017-06-30 | 2020-05-19 | Mevion Medical Systems, Inc. | Configurable collimator controlled using linear motors |
JP7311620B2 (en) | 2019-03-08 | 2023-07-19 | メビオン・メディカル・システムズ・インコーポレーテッド | Collimators and energy degraders for particle therapy systems |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL112025C (en) * | 1959-01-23 | |||
US3175131A (en) * | 1961-02-08 | 1965-03-23 | Richard J Burleigh | Magnet construction for a variable energy cyclotron |
FR2139671B1 (en) * | 1971-05-28 | 1974-03-22 | Thomson Csf | |
LU85895A1 (en) * | 1985-05-10 | 1986-12-05 | Univ Louvain | CYCLOTRON |
BE1005530A4 (en) * | 1991-11-22 | 1993-09-28 | Ion Beam Applic Sa | Cyclotron isochronous |
US5463291A (en) * | 1993-12-23 | 1995-10-31 | Carroll; Lewis | Cyclotron and associated magnet coil and coil fabricating process |
-
1995
- 1995-10-06 BE BE9500832A patent/BE1009669A3/en not_active IP Right Cessation
-
1996
- 1996-09-25 US US09/051,306 patent/US6057655A/en not_active Expired - Lifetime
- 1996-09-25 WO PCT/BE1996/000101 patent/WO1997014279A1/en active IP Right Grant
- 1996-09-25 DE DE69603497T patent/DE69603497T2/en not_active Expired - Lifetime
- 1996-09-25 AT AT96931694T patent/ATE182739T1/en active
- 1996-09-25 JP JP51457797A patent/JP4008030B2/en not_active Expired - Fee Related
- 1996-09-25 ES ES96931694T patent/ES2135918T3/en not_active Expired - Lifetime
- 1996-09-25 EP EP96931694A patent/EP0853867B1/en not_active Expired - Lifetime
-
1999
- 1999-09-30 GR GR990402483T patent/GR3031392T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE69603497T2 (en) | 2000-02-03 |
GR3031392T3 (en) | 2000-01-31 |
ATE182739T1 (en) | 1999-08-15 |
JP4008030B2 (en) | 2007-11-14 |
EP0853867A1 (en) | 1998-07-22 |
BE1009669A3 (en) | 1997-06-03 |
DE69603497D1 (en) | 1999-09-02 |
WO1997014279A1 (en) | 1997-04-17 |
ES2135918T3 (en) | 1999-11-01 |
US6057655A (en) | 2000-05-02 |
JPH11513528A (en) | 1999-11-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0853867B1 (en) | Method for sweeping charged particles out of an isochronous cyclotron, and device therefor | |
EP0613607B1 (en) | Compact isochronic cyclotron | |
EP1566082B1 (en) | Cyclotron | |
FR2472292A1 (en) | FREE ELECTRON LASER USING A CATALYTIC LINEAR ACCELERATOR | |
EP0013242B1 (en) | Generator for very high frequency electromagnetic waves | |
EP1385362A1 (en) | Cyclotron provided with new particle beam sweeping means | |
FR2531570A1 (en) | NEGATIVE ION SOURCE AND METHOD USING THE SOURCE TO REDUCE ELECTRONS NOT DESIRED OF AN OUTPUT FLOW | |
EP0248689A1 (en) | Multiple-beam klystron | |
WO2012055958A1 (en) | Synchrocyclotron | |
EP0410880A1 (en) | Free electron laser with improved electron accelerator | |
FR2899426A1 (en) | Low power x-ray generator for realizing non-invasive examination of object, has voltage multipliers arranged in shadow zones created by anode and cathode of bipolar x-ray tube and located behind respective inputs of cathode and anode | |
EP0499514B1 (en) | Mode converter and power-dividing device for a microwave tube, and microwave tube with such a device | |
EP2633741B1 (en) | Synchrocyclotron | |
EP0336850B1 (en) | Linear accelerator with self-focalising cavities, with high electron capture rate at low injection voltages | |
BE1003551A3 (en) | CYCLOTRONS FOCUSED BY SECTORS. | |
EP2311061B1 (en) | Electron cyclotron resonance ion generator | |
FR2651406A1 (en) | FREE ELECTRON LASER. | |
EP0238375A1 (en) | Apparatus and method for the production of a braking radiation from accelerated electrons | |
WO2023170116A1 (en) | Cyclotron having separate bi-sectors | |
FR2680940A1 (en) | ELECTROSTATIC ACCELERATOR AND FREE ELECTRON LASER USING THE ACCELERATOR. | |
FR2699325A1 (en) | Elimination of instability in a cross-field amplifier using a field emitter. | |
FR2598850A1 (en) | AXIAL FLOW PLASMA SHUTTER | |
FR2526582A1 (en) | METHOD AND APPARATUS FOR PRODUCING MICROWAVE | |
Ramos et al. | The trapped-particle instability in the Boeing 1kW FEL oscillator | |
Dubrovin et al. | Lasertron performance simulation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19971229 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
17Q | First examination report despatched |
Effective date: 19981103 |
|
GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
GRAH | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOS IGRA |
|
GRAH | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOS IGRA |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
REF | Corresponds to: |
Ref document number: 182739 Country of ref document: AT Date of ref document: 19990815 Kind code of ref document: T |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: NV Representative=s name: ABREMA AGENCE BREVETS ET MARQUES GANGUILLET & HUMP |
|
REF | Corresponds to: |
Ref document number: 69603497 Country of ref document: DE Date of ref document: 19990902 |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D Free format text: FRENCH |
|
ITF | It: translation for a ep patent filed |
Owner name: MODIANO & ASSOCIATI S.R.L. |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FG2A Ref document number: 2135918 Country of ref document: ES Kind code of ref document: T3 |
|
GBT | Gb: translation of ep patent filed (gb section 77(6)(a)/1977) |
Effective date: 19991028 |
|
REG | Reference to a national code |
Ref country code: PT Ref legal event code: SC4A Free format text: AVAILABILITY OF NATIONAL TRANSLATION Effective date: 19991028 |
|
REG | Reference to a national code |
Ref country code: DK Ref legal event code: T3 |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
26N | No opposition filed | ||
REG | Reference to a national code |
Ref country code: GB Ref legal event code: IF02 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: MC Payment date: 20100823 Year of fee payment: 15 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: LU Payment date: 20100826 Year of fee payment: 15 Ref country code: FI Payment date: 20100823 Year of fee payment: 15 Ref country code: AT Payment date: 20100823 Year of fee payment: 15 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GR Payment date: 20100823 Year of fee payment: 15 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: PT Payment date: 20100906 Year of fee payment: 15 Ref country code: DK Payment date: 20100824 Year of fee payment: 15 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: IE Payment date: 20110826 Year of fee payment: 16 Ref country code: CH Payment date: 20110829 Year of fee payment: 16 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GB Payment date: 20110830 Year of fee payment: 16 Ref country code: SE Payment date: 20110824 Year of fee payment: 16 Ref country code: DE Payment date: 20110902 Year of fee payment: 16 Ref country code: ES Payment date: 20110913 Year of fee payment: 16 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: BE Payment date: 20110824 Year of fee payment: 16 Ref country code: IT Payment date: 20110826 Year of fee payment: 16 Ref country code: NL Payment date: 20110826 Year of fee payment: 16 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 20111007 Year of fee payment: 16 |
|
REG | Reference to a national code |
Ref country code: PT Ref legal event code: MM4A Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20120326 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MC Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110930 |
|
REG | Reference to a national code |
Ref country code: DK Ref legal event code: EBP |
|
REG | Reference to a national code |
Ref country code: GR Ref legal event code: ML Ref document number: 990402483 Country of ref document: GR Effective date: 20120403 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110925 Ref country code: PT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20120326 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20120403 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: DK Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110930 |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: MM01 Ref document number: 182739 Country of ref document: AT Kind code of ref document: T Effective date: 20110925 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: AT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110925 |
|
BERE | Be: lapsed |
Owner name: S.A. *ION BEAM APPLICATIONS Effective date: 20120930 |
|
REG | Reference to a national code |
Ref country code: NL Ref legal event code: V1 Effective date: 20130401 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20120926 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL Ref country code: SE Ref legal event code: EUG |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20120925 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110925 |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: MM4A |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: ST Effective date: 20130531 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130403 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20120930 Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20120925 Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20120925 Ref country code: BE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20120930 Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20120930 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20120925 Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20121001 Ref country code: NL Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130401 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 69603497 Country of ref document: DE Effective date: 20130403 |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FD2A Effective date: 20131021 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: ES Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20120926 |