EP0839544B1 - Inhalateurs - Google Patents

Inhalateurs Download PDF

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Publication number
EP0839544B1
EP0839544B1 EP97308548A EP97308548A EP0839544B1 EP 0839544 B1 EP0839544 B1 EP 0839544B1 EP 97308548 A EP97308548 A EP 97308548A EP 97308548 A EP97308548 A EP 97308548A EP 0839544 B1 EP0839544 B1 EP 0839544B1
Authority
EP
European Patent Office
Prior art keywords
inhaler
mouthpiece
outlet
duct
housing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP97308548A
Other languages
German (de)
English (en)
Other versions
EP0839544A3 (fr
EP0839544A2 (fr
Inventor
David Howlett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consort Medical PLC
Original Assignee
Bespak PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bespak PLC filed Critical Bespak PLC
Publication of EP0839544A2 publication Critical patent/EP0839544A2/fr
Publication of EP0839544A3 publication Critical patent/EP0839544A3/fr
Application granted granted Critical
Publication of EP0839544B1 publication Critical patent/EP0839544B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
    • A61M16/122—Preparation of respiratory gases or vapours by mixing different gases with dilution
    • A61M16/125—Diluting primary gas with ambient air
    • A61M16/127—Diluting primary gas with ambient air by Venturi effect, i.e. entrainment mixers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0096—Hindering inhalation before activation of the dispenser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Definitions

  • the invention relates to an inhaler for products such as medicaments and particularly to an inhaler for transferring to a patient a metered dose of medicament contained in a pressurised dispensing container.
  • the aerosol stream from a pressurised dispensing container is fired towards a patient or user of the inhaler into an air flow travelling in the same direction.
  • a user inhales through a mouth piece of the inhaler and creates an air flow through the container from air inlet holes which are generally at a part of the inhaler well spaced from the mouth piece.
  • the medicament is then released into this air flow at a point between the air inlet holes and the mouth piece so that it is travelling in the same direction as the air flow.
  • U.S. 5,435,297 discloses a medical device for inhaling a metered aerosol comprising a cylindrical housing with a receiving chamber and first main air channels extending axially within the housing.
  • a mouthpiece is co-axially connected to the housing.
  • An atomising and vortexing chamber is delimited by the housing and the mouthpiece.
  • Second main air channels extend within the mouthpiece and communicate with the first main air channels.
  • Branch air channels extend at a slant to an axial direction within a partition positioned between the receiving chamber and the atomising and vortexing chamber.
  • the branch air channels are connected to the first main air channels and open into the atomising and vortexing chamber. Inhaled airflow through the branch channels aids the atomisation of the aerosol. However, the branch channels do not slow the velocity of the dispensed medicament. Rather, they tend to increase the velocity of the medicament particles.
  • GB 1 118 341 discloses an inhalation device incorporating air barriers to impart a swirling motion to air entering the device.
  • the present invention seeks to provide an inhaler which allows delivery of medicament to a user at reduced velocity without significantly increasing the size of the inhaler.
  • the invention therefore provides an inhaler for medicament comprising a housing for receiving a pressurised dispensing container of medicament, a mouthpiece for insertion into the mouth of a user of the inhaler, a duct suitable to connect an outlet of container with the mouthpiece said duct ending in an outlet, at least one air inlet for allowing air into the inhaler, the air inlet(s) being positioned downstream relative to the duct outlet, and a restricted airflow passage being provided between the air inlet(s) and a location adjacent to the outlet of the duct, wherein vortex generating means are provided in the restricted airflow passage, such that, in use, when a user inhales through the mouthpiece, a swirling airflow is created from the inlet(s) to the mouthpiece along the passage towards the duct outlet, the airflow having a component directed in reverse to the airflow from the duct outlet of the mouthpiece, characterised in that the vortex generating means comprise a plurality of raised vanes in the restricted airflow passage at an angle of incidence to the
  • an actuator or inhaler 10 for a product such as a medicament comprises a housing 11 for receiving a pressurised dispensing container 12 of medicament, a mouth piece 14 for insertion into the mouth of a user of the inhaler 10 and a cover 15 for the mouth piece 14.
  • the container housing 11 is generally cylindrical and open at its upper end.
  • a lower wall 17 of the housing 11 includes a socket 18 defining a seat for receiving the tubular valve stem 13 of the container 12.
  • the socket 18 communicates, via a duct 16 ending in an orifice 19, with the mouth piece 14.
  • the mouth piece 14 which may be generally circular or shaped to fit the mouth, is connected to the housing 11 through a generally frusto-conical wall portion 20.
  • the wall portion 20 includes inner and outer walls 21, 22, the inner wall 21 being an extension of the mouth piece 14.
  • the outer wall 22 forms, with the inner wall 21, a restricted air flow passage from inlet air holes 23 provided in the outer wall 22 around the periphery of the mouth piece 14 to a restricted air inlet 25 adjacent a neck portion 24 of the device 10.
  • On the inner surface of outer wall 22 are formed means 30 for generating a vortex.
  • the vortex generator 30 as shown in Figs.
  • 4 and 5 comprises four raised vanes 30 located around the inner surface of the outer wall 22 at an angle of incidence to the air flow, and oriented so as to converge in a direction from the air inlets 23 to the duct outlet 19.
  • the inner wall 21 seals against the top surfaces of the vanes 30.
  • the cover 15 of the device 10 which fits over the open mouth piece 14 is connected by a flexible hinge portion 27 to a cover attachment 28 which fits in the lower part of the housing 11 to attach the cover 15 to the housing 11.
  • All of the components of the inhaler 10 may be plastics mouldings.
  • housing 11 forms a barrier between the open end of the housing 11 and the mouth piece 14 so that there is no air flow passage from around the container 12, or the left side of the housing 11 (as viewed in the drawing), to the mouth piece 14.
  • the inhaler 10 In use of the inhaler 10, a patient or user holds the inhaler 10, usually in one hand, and applies his mouth to the mouth piece 14. The user then inhales through the mouth piece 14 and this creates an air flow from inlet air holes 23 along the channels created between the vanes 30, and the inner and outer walls 21, 22, via the restricted air inlet 25 to the mouth piece 14. It will be appreciated that the inlet air holes 23 are arranged downstream of the orifices 19 relative to the mouth piece 14, that is to say the inlet air holes 23 are axially closer to the mouth piece 14 than the neck portion 24 and orifice 19.
  • the reverse flow component of air flow and the vortex created by the vortex generator ensure that the velocity of medicament particles is relatively low when they enter the oro-pharynx region of the patient.
  • the spray pattern formed during use of a prior art inhaler is shown in Fig. 2. This spray is a high velocity, narrow cone, downwardly angled spray shown by the shaded envelope.
  • the spray pattern formed during use of the inhaler of the present invention is illustrated in Fig. 3.
  • the spray pattern is much wider and more upwardly angled as the product is dispersed with a greater volume of air.
  • the inhaler 10 is more effective and more comfortable to use.
  • the cover 15 When not in use, the cover 15 is placed over the mouth piece 14 in the and when the inhaler is to be used, the cover is removed by hinging it away from the mouth piece 14.
  • FIG. 8 An alternative construction of vortex generator for use in the present invention is illustrated in Figs. 8 and 9. In this arrangement the vanes 31 are curved.
  • vanes Although only four vanes are shown in the foregoing embodiments, other numbers of vanes can be used which provide sufficient swirl to the air flow.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medicinal Preparation (AREA)

Claims (4)

  1. Inhalateur (10) pour un médicament comportant un corps (11) destiné à recevoir un récipient (12) de distribution d'un médicament sous pression, un embout (14) destiné à être introduit dans la bouche d'un utilisateur de l'inhalateur, un conduit (16) apte à raccorder une sortie du récipient à l'embout (14), ledit conduit (16) se terminant dans une sortie (19), au moins une entrée d'air (23) pour permettre l'admission d'air dans l'inhalateur, l'entrée ou les entrées d'air (23) étant positionnées en aval par rapport à la sortie (19) du conduit, et un passage étranglé d'écoulement d'air étant prévu entre l'entrée et les entrées d'air (23) et un emplacement adjacent à la sortie (19) du conduit (16), dans lequel des moyens (30) de génération de tourbillons sont prévus dans le passage étranglé d'écoulement d'air afin que, lors de l'utilisation, lorsqu'un utilisateur inhale à travers l'embout (14), un écoulement d'air tourbillonnaire soit engendré dans l'entrée ou les entrées (23) vers l'embout (14) le long du passage vers la sortie (19) du conduit, l'écoulement d'air ayant une composante dirigée en sens inverse de l'écoulement d'air provenant de la sortie (19) de conduit de l'embout (14), caractérisé en ce que les moyens de génération de tourbillon comprennent plusieurs ailettes (30) en saillie dans le passage étranglé d'écoulement d'air sous un angle d'incidence avec l'écoulement d'air, et orientées de façon à converger dans une direction allant de ladite, au moins une, entrée d'air (23) vers ladite sortie (19).
  2. Inhalateur (10) selon la revendication 1, dans lequel le passage étranglé d'écoulement d'air est formé entre une paroi (20) du corps (11) destinée à recevoir l'embout (14) et les moyens (30) de génération de tourbillon sont situés sur la paroi (20) dudit corps.
  3. Inhalateur (10) selon l'une quelconque des revendications précédentes, dans lequel les ailettes (30) sont à côtés droits.
  4. Inhalateur (10) selon la revendication 1 ou la revendication 2, dans lequel les ailettes (30) sont incurvées.
EP97308548A 1996-10-30 1997-10-27 Inhalateurs Expired - Lifetime EP0839544B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9622546 1996-10-30
GB9622546A GB2318737B (en) 1996-10-30 1996-10-30 Improved inhalers

Publications (3)

Publication Number Publication Date
EP0839544A2 EP0839544A2 (fr) 1998-05-06
EP0839544A3 EP0839544A3 (fr) 1998-11-25
EP0839544B1 true EP0839544B1 (fr) 2003-07-02

Family

ID=10802139

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97308548A Expired - Lifetime EP0839544B1 (fr) 1996-10-30 1997-10-27 Inhalateurs

Country Status (4)

Country Link
US (1) US6062214A (fr)
EP (1) EP0839544B1 (fr)
DE (1) DE69723202T2 (fr)
GB (1) GB2318737B (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008502544A (ja) * 2004-06-14 2008-01-31 バルワー エス．アー．エス． 流体ディスペンサ装置
US7865232B1 (en) 2007-08-07 2011-01-04 Pacesetter, Inc. Method and system for automatically calibrating ischemia detection parameters
US7900637B2 (en) 2001-06-25 2011-03-08 Niconovum Ab Device and method for the administration of a substance
US7949388B1 (en) 2007-03-16 2011-05-24 Pacesetter, Inc. Methods and systems to characterize ST segment variation over time
US8517009B2 (en) 2008-07-13 2013-08-27 Map Pharmaceuticals, Inc. Methods and apparatus for delivering aerosolized medication
US8741348B2 (en) 2002-12-20 2014-06-03 Niconovum Ab Physically and chemically stable nicotine-containing particulate material

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JP4423457B2 (ja) 1998-01-16 2010-03-03 トルーデル メディカル インターナショナル ディスペンサおよび投与装置用表示装置
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UA73924C2 (en) * 1998-10-09 2005-10-17 Nektar Therapeutics Device for delivering active agent formulation to lungs of human patient
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CN100591378C (zh) * 2002-06-27 2010-02-24 奥里尔治疗公司 干粉剂量装填系统和相关方法
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CN101810901B (zh) 2005-01-20 2013-07-24 特鲁德尔医学国际公司 分配装置
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CA2646942C (fr) 2006-03-16 2014-07-29 Niconovum Ab Composition amelioree de tabac a priser
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ES2507504T3 (es) * 2006-08-22 2014-10-15 Glaxo Group Limited Accionador para un inhalador
US20110259323A1 (en) * 2006-08-22 2011-10-27 Gary Thomas Crosby Actuator for an inhaler
CN101528292A (zh) * 2006-08-22 2009-09-09 葛兰素集团有限公司 用于吸入器的致动器
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US8181591B1 (en) 2008-05-23 2012-05-22 Trudell Medical International Domed actuator for indicating device
US8596265B2 (en) 2008-10-22 2013-12-03 Trudell Medical International Modular aerosol delivery system
RU2561570C2 (ru) * 2010-09-06 2015-08-27 Кьези Фармасьютичи С.П.А. Исполнительный механизм дозирующего ингалятора и дозирующий ингалятор
US9004063B1 (en) * 2011-08-17 2015-04-14 Shane M. Guldbransen Portable oxygen inhaler device
US9713687B2 (en) * 2012-08-21 2017-07-25 Philip Morris Usa Inc. Ventilator aerosol delivery system with transition adapter for introducing carrier gas
MA43782A (fr) 2016-03-31 2021-04-28 Chiesi Farm Spa Dispositif d'inhalation d'aérosol
EP3743140B1 (fr) 2018-01-23 2024-08-28 SHL Medical AG Générateur d'aérosol
CN110201278B (zh) * 2018-02-28 2021-07-30 张江 用于吸入给药的药盒和吸入给药组合结构

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7900637B2 (en) 2001-06-25 2011-03-08 Niconovum Ab Device and method for the administration of a substance
US8741348B2 (en) 2002-12-20 2014-06-03 Niconovum Ab Physically and chemically stable nicotine-containing particulate material
JP2008502544A (ja) * 2004-06-14 2008-01-31 バルワー エス．アー．エス． 流体ディスペンサ装置
US7949388B1 (en) 2007-03-16 2011-05-24 Pacesetter, Inc. Methods and systems to characterize ST segment variation over time
US7865232B1 (en) 2007-08-07 2011-01-04 Pacesetter, Inc. Method and system for automatically calibrating ischemia detection parameters
US8517009B2 (en) 2008-07-13 2013-08-27 Map Pharmaceuticals, Inc. Methods and apparatus for delivering aerosolized medication
US9216259B2 (en) 2008-07-13 2015-12-22 Map Pharmaceuticals, Inc. Methods and apparatus for delivering aerosolized medication

Also Published As

Publication number Publication date
DE69723202D1 (de) 2003-08-07
DE69723202T2 (de) 2004-06-03
GB2318737A (en) 1998-05-06
GB2318737B (en) 2000-06-14
EP0839544A3 (fr) 1998-11-25
US6062214A (en) 2000-05-16
EP0839544A2 (fr) 1998-05-06
GB9622546D0 (en) 1997-01-08

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