EP0828823A4 - Herpes simplex type 1 protease mutants and vectors - Google Patents

Herpes simplex type 1 protease mutants and vectors

Info

Publication number
EP0828823A4
EP0828823A4 EP96916676A EP96916676A EP0828823A4 EP 0828823 A4 EP0828823 A4 EP 0828823A4 EP 96916676 A EP96916676 A EP 96916676A EP 96916676 A EP96916676 A EP 96916676A EP 0828823 A4 EP0828823 A4 EP 0828823A4
Authority
EP
European Patent Office
Prior art keywords
vectors
herpes simplex
simplex type
protease mutants
mutants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96916676A
Other languages
German (de)
French (fr)
Other versions
EP0828823A1 (en
Inventor
R Bruce Register
Jules A Shafer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0828823A1 publication Critical patent/EP0828823A1/en
Publication of EP0828823A4 publication Critical patent/EP0828823A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP96916676A 1995-06-01 1996-05-28 Herpes simplex type 1 protease mutants and vectors Withdrawn EP0828823A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45755895A 1995-06-01 1995-06-01
US457558 1995-06-01
PCT/US1996/007795 WO1996038546A1 (en) 1995-06-01 1996-05-28 Herpes simplex type 1 protease mutants and vectors

Publications (2)

Publication Number Publication Date
EP0828823A1 EP0828823A1 (en) 1998-03-18
EP0828823A4 true EP0828823A4 (en) 1999-02-10

Family

ID=23817195

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96916676A Withdrawn EP0828823A4 (en) 1995-06-01 1996-05-28 Herpes simplex type 1 protease mutants and vectors

Country Status (3)

Country Link
EP (1) EP0828823A4 (en)
CA (1) CA2222877A1 (en)
WO (1) WO1996038546A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0176170A1 (en) * 1984-06-04 1986-04-02 Pasteur Merieux Serums Et Vaccins Herpes simplex virus as a vector
EP0514830A2 (en) * 1991-05-24 1992-11-25 Arch Development Corporation Methods and compositions of a preparation and use of a herpes protease

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0953648A3 (en) * 1990-09-25 2007-09-12 Cantab Pharmaceuticals Research Limited Viral defective vaccine produced by transcomplementing cell line

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0176170A1 (en) * 1984-06-04 1986-04-02 Pasteur Merieux Serums Et Vaccins Herpes simplex virus as a vector
EP0514830A2 (en) * 1991-05-24 1992-11-25 Arch Development Corporation Methods and compositions of a preparation and use of a herpes protease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
REGISTER R.B. & SHAFER J.A.: "A facile system for construction of HSV-1 variants: site directed mutation of the UL26 protease gene in HSV-1", J. VIROL. METHODS, vol. 57, no. 2, 5 April 1996 (1996-04-05), pages 181 - 193, XP002086857 *
See also references of WO9638546A1 *

Also Published As

Publication number Publication date
CA2222877A1 (en) 1996-12-05
EP0828823A1 (en) 1998-03-18
WO1996038546A1 (en) 1996-12-05

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Legal Events

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