EP0807165A4 - RECOMBINANT -g(a)-GALACTOSIDASE ENZYME - Google Patents

RECOMBINANT -g(a)-GALACTOSIDASE ENZYME

Info

Publication number
EP0807165A4
EP0807165A4 EP96903741A EP96903741A EP0807165A4 EP 0807165 A4 EP0807165 A4 EP 0807165A4 EP 96903741 A EP96903741 A EP 96903741A EP 96903741 A EP96903741 A EP 96903741A EP 0807165 A4 EP0807165 A4 EP 0807165A4
Authority
EP
European Patent Office
Prior art keywords
recombinant
galactosidase enzyme
galactosidase
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96903741A
Other languages
German (de)
French (fr)
Other versions
EP0807165A1 (en
Inventor
Alex Zhu
Jack Goldstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York Blood Center Inc
Original Assignee
New York Blood Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Blood Center Inc filed Critical New York Blood Center Inc
Publication of EP0807165A1 publication Critical patent/EP0807165A1/en
Publication of EP0807165A4 publication Critical patent/EP0807165A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
EP96903741A 1995-01-30 1996-01-30 RECOMBINANT -g(a)-GALACTOSIDASE ENZYME Withdrawn EP0807165A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US380194 1982-05-20
US38019495A 1995-01-30 1995-01-30
PCT/US1996/001212 WO1996023869A1 (en) 1995-01-30 1996-01-30 RECOMBINANT α-GALACTOSIDASE ENZYME

Publications (2)

Publication Number Publication Date
EP0807165A1 EP0807165A1 (en) 1997-11-19
EP0807165A4 true EP0807165A4 (en) 1998-07-15

Family

ID=23500271

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96903741A Withdrawn EP0807165A4 (en) 1995-01-30 1996-01-30 RECOMBINANT -g(a)-GALACTOSIDASE ENZYME

Country Status (5)

Country Link
EP (1) EP0807165A4 (en)
JP (1) JPH10513057A (en)
AU (1) AU4772596A (en)
CA (1) CA2211417A1 (en)
WO (1) WO1996023869A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458574B1 (en) * 1996-09-12 2002-10-01 Transkaryotic Therapies, Inc. Treatment of a α-galactosidase a deficiency
US7767415B2 (en) 2001-09-25 2010-08-03 Velico Medical, Inc. Compositions and methods for modifying blood cell carbohydrates
CA2696699A1 (en) 2007-08-20 2009-02-26 Protalix Ltd. Saccharide-containing protein conjugates and uses thereof
US20120230974A1 (en) * 2009-11-17 2012-09-13 Protalix Ltd Alkaline alpha galactosidase for the treatment of fabry disease
US9194011B2 (en) 2009-11-17 2015-11-24 Protalix Ltd. Stabilized alpha-galactosidase and uses thereof
CN103443270B (en) 2011-01-20 2017-06-06 普罗塔里克斯有限公司 For the nucleic acid construct of the express alpha galactosidase in plant and plant cell
CN114752581B (en) * 2022-04-20 2023-05-26 南京工业大学 Alpha-galactosidase mutant and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987007641A1 (en) * 1986-06-03 1987-12-17 Unilever Nv Production of guar alpha-galactosidase by hosts transformed with recombinant dna methods
WO1994009123A1 (en) * 1992-10-22 1994-04-28 The New York Blood Center, Inc. Recycling of enzymes used to convert sub-type a, b and ab erythrocytes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69133066T2 (en) * 1990-01-16 2003-03-06 Ct Ingenieria Genetica Biotech Process for the expression of heterological genes in the yeast Pichia Pastoris, expression process and transformed microorganisms
US5330901A (en) * 1991-04-26 1994-07-19 Research Corporation Technologies, Inc. Expression of human serum albumin in Pichia pastoris

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987007641A1 (en) * 1986-06-03 1987-12-17 Unilever Nv Production of guar alpha-galactosidase by hosts transformed with recombinant dna methods
WO1994009123A1 (en) * 1992-10-22 1994-04-28 The New York Blood Center, Inc. Recycling of enzymes used to convert sub-type a, b and ab erythrocytes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
See also references of WO9623869A1 *
ZHU A ET AL: "Cloning and functional expression of a cDNA encoding coffee bean alpha-galactosidase.", GENE, MAR 25 1994, 140 (2) P227-31, NETHERLANDS, XP002062116 *
ZHU, ALEX GOLDSTEIN, JACK: "High-level expression and purification of coffee bean alpha-galactosidase produced in the yeast Pichia pastoris.", ARCH BIOCHEM BIOPHYS, DEC 1 1995, 324 (1) P65-70, UNITED STATES, XP002062117 *

Also Published As

Publication number Publication date
AU4772596A (en) 1996-08-21
WO1996023869A1 (en) 1996-08-08
CA2211417A1 (en) 1996-08-08
EP0807165A1 (en) 1997-11-19
JPH10513057A (en) 1998-12-15

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19970827

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Ipc: C12N 15/56

A4 Supplementary search report drawn up and despatched

Effective date: 19980529

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Effective date: 20010709

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20030812