EP0803449A1 - Improvements in or relating to valve for dispensers - Google Patents
Improvements in or relating to valve for dispensers Download PDFInfo
- Publication number
- EP0803449A1 EP0803449A1 EP97302729A EP97302729A EP0803449A1 EP 0803449 A1 EP0803449 A1 EP 0803449A1 EP 97302729 A EP97302729 A EP 97302729A EP 97302729 A EP97302729 A EP 97302729A EP 0803449 A1 EP0803449 A1 EP 0803449A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- chamber
- valve stem
- valve
- fluid inlet
- dispensing apparatus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/44—Valves specially adapted therefor; Regulating devices
- B65D83/52—Valves specially adapted therefor; Regulating devices for metering
- B65D83/54—Metering valves ; Metering valve assemblies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/42—Filling or charging means
- B65D83/425—Delivery valves permitting filling or charging
Definitions
- the invention relates to improvements in valves for dispensers for dispensing an accurately metered dose of a product.
- the accuracy of the metered dose of an active drug is very important for dispensing drugs and medicaments and more attention is being paid nowadays to the consistent accuracy of every dose supplied by pharmaceutical dispensing means.
- One problem in particular which has been noted is the loss of prime. This is usually characterised by the measure of the product (i.e. the complete formulation) which is dispensed from the valve following storage in adverse conditions and/or for an extended duration. This can equate to storage of the dispenser with the valve pointing upwards for up to 24 hours as this replicates the more severe aspects of patient usage. If the total amount of formulation dispensed is reduced, then it also follows that the amount of active substance dispensed is also below specification.
- drain back the liquid drains out of the metered volume of the valve (this is often referred to as "drain back") back into the storage container.
- the principal factors controlling such drain back would be the flow path geometry and fluid properties such as surface tension and viscosity.
- a common approach adopted to improve drain back is to either restrict this flow path, or make the route more tortuous.
- a second explanation is more complex and results from the thermodynamic properties of the liquified propellants normally employed in such dispensers and in particularly in metered dose inhalers.
- the propellants give off a vapour, consisting of molecules of substance. If the substance is in an enclosed space, as it is in a dispensing container, the pressure of the vapour will reach a maximum that depends on the nature of the substance and the temperature. Within the closed container, at room temperatures, such propellants are in an equilibrium state, in as much as molecules of the liquid are transforming into vapour at the same time as the reverse is occurring.
- the metered volume of product is connected to the bulk of the product and this vapourisation also occurs in the metering chamber.
- dispensing apparatus for dispensing a product from a pressurised container comprising a metering valve, said valve comprising a valve body defining a metering chamber, an outer annular seal closing an outer end of said chamber, an inner annular seal at an inner end of said chamber, a valve stem extending in sliding sealed relation through the chamber and engaging at its inner end a valve stem member spring means urging the valve stem member into sealing engagement with the inner seal such that the chamber is sealed, the valve stem being manually movable against the action of the spring means to unseat the valve stem member into a first position in which a product inlet path is opened into the chamber to enable filling of the chamber, the valve stem being movable further to a second position in which the product inlet path is closed and a product outlet path from the chamber is opened to enable the product to be dispensed from the chamber.
- the metering chamber is thus filled dynamically following deliveries of a dose by the user. Provided that the flow path into the chamber is significant, refilling is almost instantaneous, so the chamber only needs to be open for a short period of time. Once filled the chamber is fully closed and sealed as the valve comes to rest, preventing either drain back or equilibrium displacement as the creation of a vapour bubble in a closed chamber would necessitate an increase in pressure.
- the fluid inlet path is provided by longitudinal slots in the inner end of said valve stem.
- the fluid inlet path is alternatively provided by transverse apertures in the inner end of said valve stem.
- the fluid inlet path may as a further alternative be provided by the external shaping of the inner end of the valve stem relative to the inner seal.
- valve stem is movable to an intermediate position between the first and second positions in which the fluid inlet and outlet paths close and the chamber is sealed.
- the fluid outlet path may be provided by an orifice communicating with a hollow portion of the valve stem, defining an exit channel.
- the dispensing apparatus 10 comprises a dispensing container 11 in which a product 12 is stored to be dispensed in metered doses.
- the product may be medicament or pharmaceutical in the form of a liquid or a drug substance normally in suspension or other excipients, or a product which is expelled using a liquified propellant such as a CFC or HFA or blends thereof.
- a valve assembly is held in position to seal the dispensing container 11 by a closure or ferrule 13 which is crimped to the open neck of the container 11.
- the ferrule 13 is preferably of aluminium and an elastomeric sealing gasket 14 prevents leakage of the product 12 between the ferrule 13 and the container 11.
- the valve assembly comprises a valve stem 15, preferably of a polymeric or metallic material, which extends co-axially within a valve body 16, 18 and extends from the body to be externally accessible and provides an outlet for the product 12.
- the valve body comprises a valve member 16, preferably also of a polymeric or metallic material, which defines a cylindrical metering chamber 17, and an housing 18.
- the valve member 16 has an aperture 22 in one end and is located in a shallow annular recess 19 in the housing 18 and an elastomeric sliding seal 20 (the inner seal 20) provides a liquid-tight seal therebetween.
- a further elastomeric sliding seal 21 (the outer seal 21) is located between the opposite end of the valve member 16 and the ferrule 13 to prevent leakage of the product 12 between the ferrule 13 and the valve stem 15 from the chamber 17.
- the valve stem 15 has a first section comprising a generally hollow section defining a dispensing channel 25.
- the hollow first section of the valve stem 15 has a port 26 communicating with the dispensing channel 25.
- the valve stem 15 also has a second section, one end of which is formed with longitudinal grooves 27 and a spigot 28. Positioned over this spigot 28 is a cap 29.
- the cap 29 has a flanged section 30 which provides an abutment for a return spring 31 which is located between the cap 29 and the base of the housing 18.
- the valve stem 15 also has a radially extending annular flange 24 located between the port 26 and the grooves 27.
- the spring 31 is preferably of stainless steel and is biased to urge the flange 24 on the valve stem 15 into sealing contact with the outer seal 21.
- valve stem 15 In use, the valve stem 15 is displaced axially relative to the valve assembly against the bias of the spring 31, as shown in Fig. 2. As this occurs the stem 15 slides through the outer seal 21 and the inner seal 20 and the top of the stem grooves 27 pass through the aperture 22 in the valve member 16.
- valve stem 15 Further depression of the valve stem 15, as shown in Fig. 4, causes the port 26 to pass through the outer seal 21 completely, into a position where it is in contact with the contents of the metering chamber 17.
- the preferred propellant systems used with the dispensing apparatus of the present invention are liquified gases or combinations thereof with boiling temperatures significantly below room temperature. As a result the product 12 boils evacuating the contents of the chamber 17 through the port 26 into the dispensing channel 25 as shown by the arrows in Fig. 4.
- the return spring 31 causes the stem 15 to return towards its rest position sliding through the inner and outer seals 20 and 21.
- the stem grooves 27 pass through the inner seal 20 and contact the metering chamber 17, as shown in Fig. 5, the liquid product 12 is transferred into the metering chamber 17, as shown by the arrows, at a high rate due to the pressure differential.
- the potential for filling the metering chamber 17 exists for the duration that the grooves 27 bridge the inner seal 20 and prior to creation of the seal between the cap 29 and the inner seal 20.
- the seal created at the interface of the stem cap 29 and the inner seal 20 isolates the volume of product 12 in the metering chamber 17 from the rest of the product 12 in the container 11. This liquid-tight seal prevents the loss of product 12 from the metered volume in the metering chamber 17 and thus prevents loss of prime regardless of the orientation of the dispensing apparatus.
- Fig. 6 illustrates a preferred pressure filling route for the valve assembly at the maximum point of displacement of the valve stem 15.
- the product 12 passes through the dispensing channel 25 of the valve stem 15, through the port 26 and into the metering chamber 17.
- the product 12 then passes through the aperture 22 in the end of the valve member 16 and forces the inner sliding seal 20 to deflect allowing the product 12 to escape into the housing 18, through the channel 23 and into the container 11, as shown by the arrows.
- FIG. 7 An alternative embodiment of the invention is shown in Fig. 7 which incorporates the more traditional flatter ferrule 13 and operates essentially the same as Fig. 1.
- FIG. 8 shows a similar arrangement to that of Fig. 7, but where the stem grooves 27 have been replaced with an annular clearance 37 which performs the same function.
- a similar arrangement is shown, but where the clearance 37 has been replaced with two radial ports 38, 39 of large cross sectional area in an extension 40 of the cap 29.
- the ports 38, 39 are connected via an axial transfer duct 41 and perform the re-filling operation of the same manner as the stem grooves 27.
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Nozzles (AREA)
Abstract
A dispensing apparatus (10) is provided for dispensing a product (12) from a pressurised container comprising a metering valve. The valve comprises a valve body (16,18) defining a metering chamber (17), an outer annular seal (21) closing an outer end of the chamber (17), an inner annular seal (20) at an inner end of the chamber (17) and a valve stem (15) extending in sliding sealed relation through the chamber (17) and engaging at its inner end a valve stem member. Spring means (31) are provided urging the valve stem member (29) into sealing engagement with the inner seal (20) such that the chamber (17) is sealed, the valve stem (15) being manually movable against the action of the spring means (31) to unseat the valve stem member (29) into a first position in which a fluid inlet path is opened into the chamber (17) to enable filling of the chamber (17). The valve stem (15) being movable further to a second position in which the fluid inlet path is closed and a fluid outlet path from the chamber (17) is opened to enable the product to be dispensed from the chamber (17).
Description
- The invention relates to improvements in valves for dispensers for dispensing an accurately metered dose of a product.
- The accuracy of the metered dose of an active drug is very important for dispensing drugs and medicaments and more attention is being paid nowadays to the consistent accuracy of every dose supplied by pharmaceutical dispensing means. One problem in particular which has been noted is the loss of prime. This is usually characterised by the measure of the product (i.e. the complete formulation) which is dispensed from the valve following storage in adverse conditions and/or for an extended duration. This can equate to storage of the dispenser with the valve pointing upwards for up to 24 hours as this replicates the more severe aspects of patient usage. If the total amount of formulation dispensed is reduced, then it also follows that the amount of active substance dispensed is also below specification.
- There are a number of explanations for loss of prime. The first is simply that the liquid drains out of the metered volume of the valve (this is often referred to as "drain back") back into the storage container. The principal factors controlling such drain back would be the flow path geometry and fluid properties such as surface tension and viscosity. A common approach adopted to improve drain back is to either restrict this flow path, or make the route more tortuous.
- A second explanation is more complex and results from the thermodynamic properties of the liquified propellants normally employed in such dispensers and in particularly in metered dose inhalers. The propellants give off a vapour, consisting of molecules of substance. If the substance is in an enclosed space, as it is in a dispensing container, the pressure of the vapour will reach a maximum that depends on the nature of the substance and the temperature. Within the closed container, at room temperatures, such propellants are in an equilibrium state, in as much as molecules of the liquid are transforming into vapour at the same time as the reverse is occurring. The metered volume of product is connected to the bulk of the product and this vapourisation also occurs in the metering chamber. A significant expansion to the vapour state displaces liquid from the chamber, causing a loss of prime and this can occur if the dispenser is stored with the valve pointing either upwards or downwards. It is thought likely that the actual loss of prime occurs as a combination or interaction of these two phenomena.
- It is therefore an object of the present invention to provide improved dispensing apparatus which eliminates or reduces these problems wherein the metered valve is sealed in the rest state of the valve.
- According to the invention there is provided dispensing apparatus for dispensing a product from a pressurised container comprising a metering valve, said valve comprising a valve body defining a metering chamber, an outer annular seal closing an outer end of said chamber, an inner annular seal at an inner end of said chamber, a valve stem extending in sliding sealed relation through the chamber and engaging at its inner end a valve stem member spring means urging the valve stem member into sealing engagement with the inner seal such that the chamber is sealed, the valve stem being manually movable against the action of the spring means to unseat the valve stem member into a first position in which a product inlet path is opened into the chamber to enable filling of the chamber, the valve stem being movable further to a second position in which the product inlet path is closed and a product outlet path from the chamber is opened to enable the product to be dispensed from the chamber.
- The metering chamber is thus filled dynamically following deliveries of a dose by the user. Provided that the flow path into the chamber is significant, refilling is almost instantaneous, so the chamber only needs to be open for a short period of time. Once filled the chamber is fully closed and sealed as the valve comes to rest, preventing either drain back or equilibrium displacement as the creation of a vapour bubble in a closed chamber would necessitate an increase in pressure.
- Preferably the fluid inlet path is provided by longitudinal slots in the inner end of said valve stem.
- The fluid inlet path is alternatively provided by transverse apertures in the inner end of said valve stem.
- The fluid inlet path may as a further alternative be provided by the external shaping of the inner end of the valve stem relative to the inner seal.
- Preferably the valve stem is movable to an intermediate position between the first and second positions in which the fluid inlet and outlet paths close and the chamber is sealed.
- The fluid outlet path may be provided by an orifice communicating with a hollow portion of the valve stem, defining an exit channel.
- Preferred embodiments of the present invention are described, by way of example only, with reference to the accompanying drawings in which:-
- Fig. 1 shows a cross sectional side elevation of dispensing apparatus according to the present invention;
- Figs. 2 to 5 are cross sectional side elevations of the valve of the dispensing apparatus of Fig. 1 showing the valve stem in different states of depression;
- Fig. 6 is a cross sectional side elevation of the valve of Fig. 1 undergoing filling; and
- Figs. 7 to 9 are cross sectional side elevations of alternative valve configurations for the dispensing apparatus of Fig. 1.
- Referring to Fig. 1, the dispensing
apparatus 10 comprises a dispensingcontainer 11 in which a product 12 is stored to be dispensed in metered doses. The product may be medicament or pharmaceutical in the form of a liquid or a drug substance normally in suspension or other excipients, or a product which is expelled using a liquified propellant such as a CFC or HFA or blends thereof. - A valve assembly is held in position to seal the dispensing
container 11 by a closure orferrule 13 which is crimped to the open neck of thecontainer 11. Theferrule 13 is preferably of aluminium and anelastomeric sealing gasket 14 prevents leakage of the product 12 between theferrule 13 and thecontainer 11. - The valve assembly comprises a
valve stem 15, preferably of a polymeric or metallic material, which extends co-axially within avalve body valve member 16, preferably also of a polymeric or metallic material, which defines acylindrical metering chamber 17, and anhousing 18. Thevalve member 16 has anaperture 22 in one end and is located in a shallowannular recess 19 in thehousing 18 and an elastomeric sliding seal 20 (the inner seal 20) provides a liquid-tight seal therebetween. - A further elastomeric sliding seal 21 (the outer seal 21) is located between the opposite end of the
valve member 16 and theferrule 13 to prevent leakage of the product 12 between theferrule 13 and thevalve stem 15 from thechamber 17. - The
valve stem 15 has a first section comprising a generally hollow section defining a dispensingchannel 25. The hollow first section of thevalve stem 15 has aport 26 communicating with the dispensingchannel 25. - The
valve stem 15 also has a second section, one end of which is formed withlongitudinal grooves 27 and aspigot 28. Positioned over thisspigot 28 is acap 29. Thecap 29 has a flanged section 30 which provides an abutment for areturn spring 31 which is located between thecap 29 and the base of thehousing 18. Thevalve stem 15 also has a radially extendingannular flange 24 located between theport 26 and thegrooves 27. - The
spring 31 is preferably of stainless steel and is biased to urge theflange 24 on thevalve stem 15 into sealing contact with theouter seal 21. - In use, the
valve stem 15 is displaced axially relative to the valve assembly against the bias of thespring 31, as shown in Fig. 2. As this occurs thestem 15 slides through theouter seal 21 and theinner seal 20 and the top of thestem grooves 27 pass through theaperture 22 in thevalve member 16. - Further travel of the
stem 15, as shown in Fig. 3, causes thestem grooves 27 to be fully located and sealed within theinner seal 20, thus isolating themetering chamber 17 from the product 12 within thecontainer 11. - Further depression of the
valve stem 15, as shown in Fig. 4, causes theport 26 to pass through theouter seal 21 completely, into a position where it is in contact with the contents of themetering chamber 17. The preferred propellant systems used with the dispensing apparatus of the present invention are liquified gases or combinations thereof with boiling temperatures significantly below room temperature. As a result the product 12 boils evacuating the contents of thechamber 17 through theport 26 into the dispensingchannel 25 as shown by the arrows in Fig. 4. - When the force on the
valve stem 15 is released, thereturn spring 31 causes thestem 15 to return towards its rest position sliding through the inner andouter seals inner seal 20 and contact themetering chamber 17, as shown in Fig. 5, the liquid product 12 is transferred into themetering chamber 17, as shown by the arrows, at a high rate due to the pressure differential. The potential for filling themetering chamber 17 exists for the duration that thegrooves 27 bridge theinner seal 20 and prior to creation of the seal between thecap 29 and theinner seal 20. - Once the
valve stem 15 is back in its rest position, as shown in Fig. 1, the seal created at the interface of thestem cap 29 and theinner seal 20 isolates the volume of product 12 in themetering chamber 17 from the rest of the product 12 in thecontainer 11. This liquid-tight seal prevents the loss of product 12 from the metered volume in themetering chamber 17 and thus prevents loss of prime regardless of the orientation of the dispensing apparatus. - Fig. 6 illustrates a preferred pressure filling route for the valve assembly at the maximum point of displacement of the
valve stem 15. The product 12 passes through the dispensingchannel 25 of thevalve stem 15, through theport 26 and into themetering chamber 17. The product 12 then passes through theaperture 22 in the end of thevalve member 16 and forces the innersliding seal 20 to deflect allowing the product 12 to escape into thehousing 18, through thechannel 23 and into thecontainer 11, as shown by the arrows. - An alternative embodiment of the invention is shown in Fig. 7 which incorporates the more traditional
flatter ferrule 13 and operates essentially the same as Fig. 1. - An alternative embodiment shown in Fig. 8 shows a similar arrangement to that of Fig. 7, but where the
stem grooves 27 have been replaced with anannular clearance 37 which performs the same function. - In the embodiment shown in Fig. 9, a similar arrangement is shown, but where the
clearance 37 has been replaced with tworadial ports extension 40 of thecap 29. Theports axial transfer duct 41 and perform the re-filling operation of the same manner as the stem grooves 27.
Claims (6)
- Dispensing apparatus (10) for dispensing a product (12) from a pressurised container (11) comprising a metering valve, said valve comprising a valve body (16, 18) defining a metering chamber (17), an outer annular seal (21) closing an outer end of said chamber (17), an inner annular seal (20) at an inner end of said chamber (17), a valve stem (15) extending in a sliding sealed relation through the chamber (17) and engaging at its inner end a valve stem member (29), spring means (31) urging the valve stem member (29) into sealing engagement with the inner seal (20) such that the chamber (17) is sealed, characterised in that the valve stem (15) being manually movable against the action of the spring means (31) to unseat the valve stem member (29) into a first position in which a fluid inlet path is opened into the chamber (17) to enable filling of the chamber (17), the valve stem (15) being movable further to a second position in which the fluid inlet path is closed and a fluid outlet path from the chamber is opened to enable the product (12) to be dispensed from the chamber (17).
- Dispensing apparatus as claimed in claim 1 in which the fluid inlet path is provided by longitudinal slots (27) in the inner end of said valve stem (15).
- Dispensing apparatus as claimed in claim 1 in which the fluid inlet path is provided by transverse apertures (38, 39) in the inner end of said valve stem (15).
- Dispensing apparatus as claimed in claim 1 in which the fluid inlet path is provided by the external shaping of the inner end of the valve stem (15) relative to the inner seal (20).
- Dispensing apparatus as claimed in claim 1 in which the valve stem (15) is movable to an intermediate position between the first and second positions in which the fluid inlet and outlet paths are closed and the chamber (17) is sealed.
- Dispensing apparatus as claimed in claim 1 in which the fluid outlet path is provided by an orifice (26) communicating with a hollow portion (25) of the valve stem (15), defining an exit channel.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9608707 | 1996-04-26 | ||
GB9608707A GB2312418A (en) | 1996-04-26 | 1996-04-26 | Valves for dispensers |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0803449A1 true EP0803449A1 (en) | 1997-10-29 |
Family
ID=10792726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97302729A Withdrawn EP0803449A1 (en) | 1996-04-26 | 1997-04-22 | Improvements in or relating to valve for dispensers |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP0803449A1 (en) |
GB (1) | GB2312418A (en) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999055600A1 (en) * | 1998-04-30 | 1999-11-04 | 3M Innovative Properties Company | Metered-dose valve for pharmaceutical aerosol |
GB2344621A (en) * | 1998-12-11 | 2000-06-14 | Bespak Plc | Seal arrangement for a pressurised dispensing container |
EP1415934A1 (en) * | 1996-12-27 | 2004-05-06 | Glaxo Group Limited | Ring for an aerosol valve |
GB2400839A (en) * | 2003-04-22 | 2004-10-27 | Bespak Plc | Apparatus and method for dispensing accurately metered doses of medicament |
US6882655B1 (en) | 1999-05-13 | 2005-04-19 | Nec Corporation | Switch and input port thereof |
CN101031484B (en) * | 2004-08-26 | 2010-12-01 | 贝斯帕克有限公司 | Metering valves used with pressurised dispensing containers |
WO2012171810A1 (en) * | 2011-06-15 | 2012-12-20 | British American Tobacco (Investments) Limited | Canister |
FR2993250A1 (en) * | 2012-10-12 | 2014-01-17 | Rexam Healthcare La Verpillier | DOSING VALVE FOR DISTRIBUTING AN AEROSOL |
WO2014057448A1 (en) | 2012-10-12 | 2014-04-17 | Rexam Healthcare La Verpilliere | Metering valve for dispensing an aerosol |
WO2014096657A1 (en) | 2012-12-17 | 2014-06-26 | Rexam Healthcare La Verpilliere | Metering valve for dispensing an aerosol |
GB202001537D0 (en) | 2020-02-05 | 2020-03-18 | Consort Medical Plc | Pressurised dispensing container |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2322847A (en) * | 1997-11-05 | 1998-09-09 | Bespak Plc | Metering valve |
GB9817685D0 (en) * | 1998-08-13 | 1998-10-07 | Bespak Plc | Metering valve |
ATE273206T1 (en) | 2001-03-26 | 2004-08-15 | 3M Innovative Properties Co | DOSSIER VALVE FOR AN IMPROVED FLOW DOSAGE INHALER |
JP2005515132A (en) | 2001-12-31 | 2005-05-26 | スリーエム イノベイティブ プロパティズ カンパニー | Valve stem used for metering valve |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1400855A (en) * | 1964-07-09 | 1965-05-28 | Aerosol metering valve | |
DE1934397A1 (en) * | 1968-07-15 | 1970-02-05 | Green Edward Howard | Valve arrangement for aerosol spray container |
US3499584A (en) * | 1966-12-21 | 1970-03-10 | Bespak Industries Ltd | Valves for pressurized dispensers |
GB1201919A (en) * | 1966-12-21 | 1970-08-12 | Bespak Industries Ltd | Improvements in or relating to valves for pressurised dispensers |
EP0101036A2 (en) * | 1982-08-09 | 1984-02-22 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Aerosol-dispenser |
EP0350376A1 (en) * | 1988-07-04 | 1990-01-10 | Valois S.A. | Metering valve for aerosols |
EP0692434A2 (en) * | 1994-07-14 | 1996-01-17 | V.A.R.I. S.p.A. | Aerosol metering valves |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2300950A1 (en) * | 1975-02-12 | 1976-09-10 | Valois Sa | AEROSOL TYPE DOSING VALVE |
FR2670139B1 (en) * | 1992-01-15 | 1993-12-24 | Valois | DOSING VALVE FOR USE IN THE REVERSE POSITION. |
-
1996
- 1996-04-26 GB GB9608707A patent/GB2312418A/en not_active Withdrawn
-
1997
- 1997-04-22 EP EP97302729A patent/EP0803449A1/en not_active Withdrawn
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1400855A (en) * | 1964-07-09 | 1965-05-28 | Aerosol metering valve | |
US3499584A (en) * | 1966-12-21 | 1970-03-10 | Bespak Industries Ltd | Valves for pressurized dispensers |
GB1201919A (en) * | 1966-12-21 | 1970-08-12 | Bespak Industries Ltd | Improvements in or relating to valves for pressurised dispensers |
DE1934397A1 (en) * | 1968-07-15 | 1970-02-05 | Green Edward Howard | Valve arrangement for aerosol spray container |
EP0101036A2 (en) * | 1982-08-09 | 1984-02-22 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Aerosol-dispenser |
EP0350376A1 (en) * | 1988-07-04 | 1990-01-10 | Valois S.A. | Metering valve for aerosols |
EP0692434A2 (en) * | 1994-07-14 | 1996-01-17 | V.A.R.I. S.p.A. | Aerosol metering valves |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1415934A1 (en) * | 1996-12-27 | 2004-05-06 | Glaxo Group Limited | Ring for an aerosol valve |
US7350676B2 (en) | 1996-12-27 | 2008-04-01 | Smithkline Beecham Corporation | Valve for aerosol container |
WO1999055600A1 (en) * | 1998-04-30 | 1999-11-04 | 3M Innovative Properties Company | Metered-dose valve for pharmaceutical aerosol |
AU738828B2 (en) * | 1998-04-30 | 2001-09-27 | 3M Innovative Properties Company | Metered-dose valve for pharmaceutical aerosol |
GB2344621A (en) * | 1998-12-11 | 2000-06-14 | Bespak Plc | Seal arrangement for a pressurised dispensing container |
GB2344621B (en) * | 1998-12-11 | 2001-03-14 | Bespak Plc | Improved seal arrangements for pressurised dispensing containers |
US6882655B1 (en) | 1999-05-13 | 2005-04-19 | Nec Corporation | Switch and input port thereof |
GB2400839A (en) * | 2003-04-22 | 2004-10-27 | Bespak Plc | Apparatus and method for dispensing accurately metered doses of medicament |
GB2400839B (en) * | 2003-04-22 | 2005-10-19 | Bespak Plc | Dispensing apparatus |
CN101031484B (en) * | 2004-08-26 | 2010-12-01 | 贝斯帕克有限公司 | Metering valves used with pressurised dispensing containers |
WO2012171810A1 (en) * | 2011-06-15 | 2012-12-20 | British American Tobacco (Investments) Limited | Canister |
FR2993250A1 (en) * | 2012-10-12 | 2014-01-17 | Rexam Healthcare La Verpillier | DOSING VALVE FOR DISTRIBUTING AN AEROSOL |
WO2014057446A1 (en) | 2012-10-12 | 2014-04-17 | Rexam Healthcare La Verpilliere | Metering valve for dispensing an aerosol |
WO2014057448A1 (en) | 2012-10-12 | 2014-04-17 | Rexam Healthcare La Verpilliere | Metering valve for dispensing an aerosol |
FR2996827A1 (en) * | 2012-10-12 | 2014-04-18 | Rexam Healthcare La Verpillier | DOSING VALVE FOR DISTRIBUTING AN AEROSOL |
CN104718140A (en) * | 2012-10-12 | 2015-06-17 | 娜敏芮维皮利业有限责任公司 | Metering valve for dispensing an aerosol |
CN104736455A (en) * | 2012-10-12 | 2015-06-24 | 娜敏芮维皮利业有限责任公司 | Metering valve for dispensing an aerosol |
US9469467B2 (en) | 2012-10-12 | 2016-10-18 | Nemera La Verpillière S.A.S. | Metering valve for dispensing an aerosol |
US9469466B2 (en) | 2012-10-12 | 2016-10-18 | Nemera La Verpillière S.A.S | Metering valve for dispensing an aerosol |
CN104718140B (en) * | 2012-10-12 | 2018-07-24 | 娜敏芮维皮利业有限责任公司 | Aerosol distributes proportional valve |
WO2014096657A1 (en) | 2012-12-17 | 2014-06-26 | Rexam Healthcare La Verpilliere | Metering valve for dispensing an aerosol |
GB202001537D0 (en) | 2020-02-05 | 2020-03-18 | Consort Medical Plc | Pressurised dispensing container |
WO2021156602A1 (en) | 2020-02-05 | 2021-08-12 | Bespak Europe Limited | Pressurised dispensing container |
Also Published As
Publication number | Publication date |
---|---|
GB9608707D0 (en) | 1996-07-03 |
GB2312418A (en) | 1997-10-29 |
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