EP0770094A4 - Modified g-protein coupled receptors - Google Patents

Modified g-protein coupled receptors

Info

Publication number
EP0770094A4
EP0770094A4 EP95922156A EP95922156A EP0770094A4 EP 0770094 A4 EP0770094 A4 EP 0770094A4 EP 95922156 A EP95922156 A EP 95922156A EP 95922156 A EP95922156 A EP 95922156A EP 0770094 A4 EP0770094 A4 EP 0770094A4
Authority
EP
European Patent Office
Prior art keywords
modified
protein coupled
coupled receptors
receptors
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95922156A
Other languages
German (de)
French (fr)
Other versions
EP0770094A1 (en
Inventor
Catherine D Strader
Candelore Maria-Luisa Rios
Xiaoming Guan
Richard Dixon
George Mcallister
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0770094A1 publication Critical patent/EP0770094A1/en
Publication of EP0770094A4 publication Critical patent/EP0770094A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP95922156A 1994-06-29 1995-06-02 Modified g-protein coupled receptors Withdrawn EP0770094A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26798794A 1994-06-29 1994-06-29
US26814794A 1994-06-29 1994-06-29
US267987 1994-06-29
PCT/US1995/006900 WO1996000739A1 (en) 1994-06-29 1995-06-02 Modified g-protein coupled receptors
US268147 1999-03-15

Publications (2)

Publication Number Publication Date
EP0770094A1 EP0770094A1 (en) 1997-05-02
EP0770094A4 true EP0770094A4 (en) 1999-05-19

Family

ID=26952801

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95922156A Withdrawn EP0770094A4 (en) 1994-06-29 1995-06-02 Modified g-protein coupled receptors

Country Status (4)

Country Link
EP (1) EP0770094A4 (en)
JP (1) JPH10502245A (en)
CA (1) CA2193809A1 (en)
WO (1) WO1996000739A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9606126D0 (en) * 1996-03-22 1996-05-22 British Biotech Pharm Biosensors
JP2002523090A (en) * 1998-09-01 2002-07-30 ビーエーエスエフ アクチェンゲゼルシャフト Enhanced functional expression of heterologous G protein-coupled receptors
US7094593B1 (en) 1998-09-01 2006-08-22 Basf Aktiengesellschaft Method for improving the function of heterologous G protein-coupled receptors
AU2001259743A1 (en) * 2000-05-12 2001-11-26 3-Dimensional Pharmaceuticals, Inc. Gpcr 4-helix and 5-helix bundles
BRPI0410491A8 (en) 2003-04-24 2017-10-24 Univ Vanderbilt COMPOSITIONS AND METHODS FOR INSECT CONTROL

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001810A1 (en) * 1990-07-19 1992-02-06 Lerner Michael R Methods of identifying compounds that act as agonists or antagonists for proteins involved in signal transduction

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001810A1 (en) * 1990-07-19 1992-02-06 Lerner Michael R Methods of identifying compounds that act as agonists or antagonists for proteins involved in signal transduction

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JIN H. ET AL.: "Characterization of the human 5-hydroxytryptamine 1B receptor", J. BIOL. CHEM., vol. 267, no. 9, 25 March 1992 (1992-03-25), pages 5735 - 5738, XP002096624 *
See also references of WO9600739A1 *
STRADER C.D. ET AL.: "Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity.", J. BIOL. CHEM., vol. 262, no. 34, 5 December 1987 (1987-12-05), pages 16439 - 16443, XP002096623 *

Also Published As

Publication number Publication date
JPH10502245A (en) 1998-03-03
WO1996000739A1 (en) 1996-01-11
CA2193809A1 (en) 1996-01-11
EP0770094A1 (en) 1997-05-02

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19970129

AK Designated contracting states

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Ipc: C12N 15/63

A4 Supplementary search report drawn up and despatched

Effective date: 19990401

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18D Application deemed to be withdrawn

Effective date: 20020503