EP0757697A4 - Use of agents which block intercellular adhesion molecule/receptor interaction in the treatment of respiratory viral infection - Google Patents

Use of agents which block intercellular adhesion molecule/receptor interaction in the treatment of respiratory viral infection

Info

Publication number
EP0757697A4
EP0757697A4 EP95916347A EP95916347A EP0757697A4 EP 0757697 A4 EP0757697 A4 EP 0757697A4 EP 95916347 A EP95916347 A EP 95916347A EP 95916347 A EP95916347 A EP 95916347A EP 0757697 A4 EP0757697 A4 EP 0757697A4
Authority
EP
European Patent Office
Prior art keywords
agents
treatment
viral infection
adhesion molecule
intercellular adhesion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95916347A
Other languages
German (de)
French (fr)
Other versions
EP0757697A1 (en
Inventor
Craig D Wegner
Ernest L Raymond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharmaceuticals Inc
Publication of EP0757697A1 publication Critical patent/EP0757697A1/en
Publication of EP0757697A4 publication Critical patent/EP0757697A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP95916347A 1994-04-12 1995-04-12 Use of agents which block intercellular adhesion molecule/receptor interaction in the treatment of respiratory viral infection Withdrawn EP0757697A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22599794A 1994-04-12 1994-04-12
PCT/US1995/004519 WO1995027736A1 (en) 1994-04-12 1995-04-12 Use of agents which block intercellular adhesion molecule/receptor interaction in the treatment of respiratory viral infection
US225997 2005-09-14

Publications (2)

Publication Number Publication Date
EP0757697A1 EP0757697A1 (en) 1997-02-12
EP0757697A4 true EP0757697A4 (en) 2000-05-17

Family

ID=22847133

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95916347A Withdrawn EP0757697A4 (en) 1994-04-12 1995-04-12 Use of agents which block intercellular adhesion molecule/receptor interaction in the treatment of respiratory viral infection

Country Status (4)

Country Link
EP (1) EP0757697A4 (en)
JP (1) JPH09512252A (en)
CA (1) CA2187360A1 (en)
WO (1) WO1995027736A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6130202A (en) * 1990-07-20 2000-10-10 Bayer Corporation Antiviral methods
US5817515A (en) * 1993-12-23 1998-10-06 Icos Corporation Human B2 integrin alpha subunit antibodies
US6391452B1 (en) 1997-07-18 2002-05-21 Bayer Corporation Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
JP2007535654A (en) * 2003-04-23 2007-12-06 ハンサ メディカル アクチボラゲット Method for identifying anti-streptococcal substances and use thereof for the treatment of streptococcal infections
US20170360815A1 (en) 2016-02-25 2017-12-21 Applied Biological Laboratories, Inc. Compositions and methods for protecting against airborne pathogens and irritants

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0289949A2 (en) * 1987-05-04 1988-11-09 Dana Farber Cancer Institute Intercellular adhesion molecules, and their binding ligands
EP0314863A2 (en) * 1987-11-02 1989-05-10 Baylor College Of Medicine Use of ICAM-1 or its functional derivatives for the treatment of non-specific inflammation
EP0391088A2 (en) * 1989-03-16 1990-10-10 Center For Blood Research Laboratories, Inc. Use of functional derivatives of the intercellular adhesion molecule ICAM-1 in anti-viral therapy
WO1993006842A1 (en) * 1991-10-02 1993-04-15 Boehringer Ingelheim Pharmaceuticals, Inc. Use of intercellular adhesion molecules, and their binding ligands in the treatment of asthma
US5235049A (en) * 1989-01-24 1993-08-10 Molecular Therapeutics, Inc. Nucleic acid sequences encoding a soluble molecule (SICAM-1) related to but distinct from ICAM-1

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0289949A2 (en) * 1987-05-04 1988-11-09 Dana Farber Cancer Institute Intercellular adhesion molecules, and their binding ligands
EP0314863A2 (en) * 1987-11-02 1989-05-10 Baylor College Of Medicine Use of ICAM-1 or its functional derivatives for the treatment of non-specific inflammation
US5235049A (en) * 1989-01-24 1993-08-10 Molecular Therapeutics, Inc. Nucleic acid sequences encoding a soluble molecule (SICAM-1) related to but distinct from ICAM-1
EP0391088A2 (en) * 1989-03-16 1990-10-10 Center For Blood Research Laboratories, Inc. Use of functional derivatives of the intercellular adhesion molecule ICAM-1 in anti-viral therapy
WO1993006842A1 (en) * 1991-10-02 1993-04-15 Boehringer Ingelheim Pharmaceuticals, Inc. Use of intercellular adhesion molecules, and their binding ligands in the treatment of asthma

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
KAPELANSKI D P ET AL: "Lung reperfusion injury is reduced by inhibiting a CD18-dependent mechanism.", JOURNAL OF HEART AND LUNG TRANSPLANTATION, (1993 MAR-APR) 12 (2) 294-306;DISCUSSION 306-7., XP000881402 *
ROTHLEIN R ET AL: "TREATMENT OF INFLAMMATION WITH ANTI-ICAM-1", RESEARCH IN IMMUNOLOGY,FR,PARIS, vol. 144, no. 9, 1 January 1993 (1993-01-01), pages 735 - 739,754-76, XP000575989 *
See also references of WO9527736A1 *
WEGNER C D ET AL: "Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma.", SCIENCE, (1990 JAN 26) 247 (4941) 456-9., XP000872999 *
WEGNER, CRAIG D: "Adhesion molecules in allergy", PROG. ALLERGY CLIN. IMMUNOL., PROC. INT. CONGR. ALLERGOL. CLIN. IMMUNOL., 15TH (1995), MEETING DATE 1994, 13-18. EDITOR(S): JOHANSSON, STIG G. O. PUBLISHER: HOGREFE & HUBER, SEATTLE, WASH., XP000881448 *

Also Published As

Publication number Publication date
CA2187360A1 (en) 1995-10-19
EP0757697A1 (en) 1997-02-12
JPH09512252A (en) 1997-12-09
WO1995027736A1 (en) 1995-10-19

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