EP0753006A4 - Vpr AND Vpx PROTEINS OF HIV - Google Patents

Vpr AND Vpx PROTEINS OF HIV

Info

Publication number
EP0753006A4
EP0753006A4 EP95912976A EP95912976A EP0753006A4 EP 0753006 A4 EP0753006 A4 EP 0753006A4 EP 95912976 A EP95912976 A EP 95912976A EP 95912976 A EP95912976 A EP 95912976A EP 0753006 A4 EP0753006 A4 EP 0753006A4
Authority
EP
European Patent Office
Prior art keywords
vpr
hiv
vpx proteins
vpx
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95912976A
Other languages
German (de)
French (fr)
Other versions
EP0753006A1 (en
Inventor
Ahmed A Azad
Ian G Macreadie
Chinniah Arunagiri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomolecular Research Institute Ltd
Original Assignee
Biomolecular Research Institute Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPM4697A external-priority patent/AUPM469794A0/en
Priority claimed from AUPN0902A external-priority patent/AUPN090295A0/en
Application filed by Biomolecular Research Institute Ltd filed Critical Biomolecular Research Institute Ltd
Publication of EP0753006A1 publication Critical patent/EP0753006A1/en
Publication of EP0753006A4 publication Critical patent/EP0753006A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP95912976A 1994-03-25 1995-03-24 Vpr AND Vpx PROTEINS OF HIV Withdrawn EP0753006A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPM4697A AUPM469794A0 (en) 1994-03-25 1994-03-25 Therapeutic compounds
AUPM4697/94 1994-03-25
AUPN0902/95 1995-02-03
AUPN0902A AUPN090295A0 (en) 1995-02-03 1995-02-03 Therapeutic compounds
PCT/AU1995/000169 WO1995026361A1 (en) 1994-03-25 1995-03-24 Vpr AND Vpx PROTEINS OF HIV

Publications (2)

Publication Number Publication Date
EP0753006A1 EP0753006A1 (en) 1997-01-15
EP0753006A4 true EP0753006A4 (en) 1999-04-14

Family

ID=25644649

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95912976A Withdrawn EP0753006A4 (en) 1994-03-25 1995-03-24 Vpr AND Vpx PROTEINS OF HIV

Country Status (4)

Country Link
EP (1) EP0753006A4 (en)
JP (1) JPH09511395A (en)
CA (1) CA2186398A1 (en)
WO (1) WO1995026361A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780220A (en) * 1994-05-19 1998-07-14 Trustees Of The University Of Pennsylvania Methods and compositions for inhibiting HIV replication
WO1996032494A1 (en) * 1995-04-14 1996-10-17 University Of Alabama Research Foundation Fusion protein delivery system and uses thereof
US6087486A (en) * 1996-01-29 2000-07-11 The Trustees Of The University Of Pennsylvania Nucleotide sequences encoding vpr receptor protein
AUPO258196A0 (en) * 1996-09-27 1996-10-17 Australian National University, The Method for determining ion channel activity of a substance
WO1998035234A1 (en) * 1997-02-11 1998-08-13 The Regents Of The University Of California Identifying agents for treating lentiviral infection
US7622300B2 (en) 1998-06-03 2009-11-24 Kappes John C Trans-lentiviral vector particles and transduction of eukaryotic cells therewith
US6555342B1 (en) 1998-06-03 2003-04-29 Uab Research Foundation Fusion protein delivery system and uses thereof
US6984486B1 (en) 1999-02-19 2006-01-10 J. David Gladstone Institutes Synthetic peptide of regulatory virus protein R (VPR) of human immunodeficiency virus type 1 (HIV-1) and the utilization thereof
DE19908752A1 (en) * 1999-02-19 2000-08-31 Ulrich Schubert New synthetic peptides from the Vpr protein of human immune deficiency virus, useful e.g. for therapy and diagnosis, have good solubility in water
WO2000049038A2 (en) 1999-02-19 2000-08-24 Ulrich Schubert Synthetic peptide of regulatory virus protein r (vpr) of human immunodeficiency virus type 1 (hiv-1) and the utilization thereof
DE19908766C2 (en) * 1999-02-19 2001-02-15 Ulrich Schubert Use of synthetic Vpr peptides of the human immunodeficiency virus type 1 (HIV-1) for the development of therapeutic and diagnostic reagents
US6664040B2 (en) * 2000-05-23 2003-12-16 The Regents Of The University Of California Compositions and methods for delivery of a molecule into a cell
AU2002350047A1 (en) * 2001-10-29 2003-05-12 Genzyme Corporation Therapeutic anti-hiv (vpr) compounds
WO2005032561A1 (en) * 2003-10-03 2005-04-14 Riken INVENTION RELATING TO FUNCTION OF HIV-Vpr
FR2868841B1 (en) * 2004-04-09 2006-07-14 Bioalliance Pharma Sa METHOD OF IDENTIFYING ACTIVE COMPOUNDS ON THE REPLICATION OF THE HIV VIRUS
WO2005103654A2 (en) * 2004-04-09 2005-11-03 Bioalliance Pharma Method for identification of compounds active in hiv virus replication

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990015875A1 (en) * 1989-06-02 1990-12-27 Dana Farber Cancer Institute Protein having a transactivating property, vectors expressing this protein, cell lines, and uses thereof
WO1994019456A1 (en) * 1993-02-19 1994-09-01 Weiner David B Vpr function and activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE147782T1 (en) * 1990-07-12 1997-02-15 Harvard College PRIMATE LENTIVIRUS VACCINES
US6107062A (en) * 1992-07-30 2000-08-22 Inpax, Inc. Antisense viruses and antisense-ribozyme viruses
AU5848794A (en) * 1993-02-05 1994-08-29 Regents Of The University Of California, The Multiple-gene mutants of human immunodeficiency virus (hiv) for vaccine use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990015875A1 (en) * 1989-06-02 1990-12-27 Dana Farber Cancer Institute Protein having a transactivating property, vectors expressing this protein, cell lines, and uses thereof
WO1994019456A1 (en) * 1993-02-19 1994-09-01 Weiner David B Vpr function and activity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COHEN E A ET AL.: "Identification of HIV-1 vpr product and function", JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, vol. 3, no. 1, 1990, new york, pages 11 - 18, XP002085625 *
See also references of WO9526361A1 *
ZHANG S ET AL: "Direct binding to nucleic acids by Vpr of human immunodeficiency virus type 1", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, vol. 212, no. 2, 8 June 1998 (1998-06-08), pages 157-166, XP004122917 *

Also Published As

Publication number Publication date
WO1995026361A1 (en) 1995-10-05
JPH09511395A (en) 1997-11-18
CA2186398A1 (en) 1995-10-05
EP0753006A1 (en) 1997-01-15

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19960916

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Effective date: 20021031