EP0726311A4 - Preparation de proteine c humaine activee et son procede de production - Google Patents

Preparation de proteine c humaine activee et son procede de production

Info

Publication number
EP0726311A4
EP0726311A4 EP94931171A EP94931171A EP0726311A4 EP 0726311 A4 EP0726311 A4 EP 0726311A4 EP 94931171 A EP94931171 A EP 94931171A EP 94931171 A EP94931171 A EP 94931171A EP 0726311 A4 EP0726311 A4 EP 0726311A4
Authority
EP
European Patent Office
Prior art keywords
activated protein
protein
preparation
human activated
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP94931171A
Other languages
German (de)
English (en)
Other versions
EP0726311A1 (fr
EP0726311B1 (fr
Inventor
Yoichi Ogata
Toshinobu Nouchi
Shinji Nakahira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemo Sero Therapeutic Research Institute Kaketsuken
Teijin Ltd
Original Assignee
Chemo Sero Therapeutic Research Institute Kaketsuken
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeutic Research Institute Kaketsuken, Teijin Ltd filed Critical Chemo Sero Therapeutic Research Institute Kaketsuken
Publication of EP0726311A1 publication Critical patent/EP0726311A1/fr
Publication of EP0726311A4 publication Critical patent/EP0726311A4/fr
Application granted granted Critical
Publication of EP0726311B1 publication Critical patent/EP0726311B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/856—Snakes; venom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
EP94931171A 1993-10-29 1994-10-27 Procede de preparation de proteine c humaine activee Expired - Lifetime EP0726311B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP5292499A JP3043558B2 (ja) 1993-10-29 1993-10-29 ヒト活性化プロテインｃ調製物及びその製法
JP29249993 1993-10-29
JP292499/93 1993-10-29
PCT/JP1994/001807 WO1995011966A1 (fr) 1993-10-29 1994-10-27 Preparation de proteine c humaine activee et son procede de production

Publications (3)

Publication Number Publication Date
EP0726311A1 EP0726311A1 (fr) 1996-08-14
EP0726311A4 true EP0726311A4 (fr) 1997-06-11
EP0726311B1 EP0726311B1 (fr) 2004-06-30

Family

ID=17782617

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94931171A Expired - Lifetime EP0726311B1 (fr) 1993-10-29 1994-10-27 Procede de preparation de proteine c humaine activee

Country Status (11)

Country Link
US (1) US5831025A (fr)
EP (1) EP0726311B1 (fr)
JP (1) JP3043558B2 (fr)
KR (1) KR100383063B1 (fr)
CN (1) CN1123639C (fr)
AT (1) ATE270327T1 (fr)
AU (1) AU680563B2 (fr)
CA (1) CA2175201C (fr)
DE (1) DE69433875T2 (fr)
ES (1) ES2224109T3 (fr)
WO (1) WO1995011966A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2886061B2 (ja) * 1993-10-29 1999-04-26 財団法人化学及血清療法研究所 プロテインｃもしくは活性化プロテインｃの安定化方法及び安定化組成物
CA2288143C (fr) * 1997-04-28 2012-08-21 Eli Lilly And Company Formulations de proteine activee
US6630137B1 (en) 1997-04-28 2003-10-07 Eli Lilly And Company Activated protein C formulations
US7204981B2 (en) * 2000-03-28 2007-04-17 Eli Lilly And Company Methods of treating diseases with activated protein C
EP1289543A2 (fr) 2000-05-24 2003-03-12 Eli Lilly And Company Preparations et techniques permettant de traiter des hypercoagulations
WO2003007686A2 (fr) * 2001-07-19 2003-01-30 Dmi Biosciences, Inc. Utilisation de chelateurs de cuivre pour inhiber l'inactivation de la proteine c
WO2003075834A2 (fr) * 2002-03-08 2003-09-18 Eli Lilly And Company Formulations de proteines c activees
ES2400853T3 (es) * 2002-12-27 2013-04-12 The Chemo-Sero-Therapeutic Research Institute Agente para mejorar la esperanza de vida en el tratamiento de una neoplasia
WO2014005183A1 (fr) 2012-07-04 2014-01-09 The University Of Sydney Traitement de troubles cutanés inflammatoires
ES2890675T3 (es) 2014-04-16 2022-01-21 Zz Biotech Llc APC para uso en el tratamiento de cicatrices cutáneas anormales

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989012685A1 (fr) * 1987-05-18 1989-12-28 Integrated Genetics, Inc. Molecules de proteine c ameliorees et procede de production et d'activation de telles molecules
WO1991012320A1 (fr) * 1990-02-09 1991-08-22 Zymogenetics, Inc. Proteine c activee a chaine legere tronquee
EP0519903A1 (fr) * 1991-06-20 1992-12-23 IMMUNO Aktiengesellschaft Médicament contenant de la protéine C activée

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968626A (en) * 1985-08-15 1990-11-06 Board Of Reagents Of The University Of Washington DNA sequence coding for protein C
US5084274A (en) * 1987-11-17 1992-01-28 Scripps Clinic And Research Foundation Inhibition of arterial thrombotic occlusion or thromboembolism
WO1991000912A1 (fr) * 1989-07-07 1991-01-24 Massachusetts Institute Of Technology Production et utilisation d'inhibiteurs de protease hybrides
JPH0564588A (ja) * 1991-08-14 1993-03-19 Teijin Ltd 短い重鎖を有するヒトプロテインｃおよび活性化ヒトプロテインｃ

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989012685A1 (fr) * 1987-05-18 1989-12-28 Integrated Genetics, Inc. Molecules de proteine c ameliorees et procede de production et d'activation de telles molecules
WO1991012320A1 (fr) * 1990-02-09 1991-08-22 Zymogenetics, Inc. Proteine c activee a chaine legere tronquee
EP0519903A1 (fr) * 1991-06-20 1992-12-23 IMMUNO Aktiengesellschaft Médicament contenant de la protéine C activée

Also Published As

Publication number Publication date
CA2175201A1 (fr) 1995-05-04
DE69433875T2 (de) 2005-07-14
ES2224109T3 (es) 2005-03-01
KR960705921A (ko) 1996-11-08
JP3043558B2 (ja) 2000-05-22
DE69433875D1 (de) 2004-08-05
CA2175201C (fr) 2007-06-12
AU8003294A (en) 1995-05-22
EP0726311A1 (fr) 1996-08-14
JPH07115972A (ja) 1995-05-09
CN1123639C (zh) 2003-10-08
CN1138349A (zh) 1996-12-18
WO1995011966A1 (fr) 1995-05-04
AU680563B2 (en) 1997-07-31
US5831025A (en) 1998-11-03
ATE270327T1 (de) 2004-07-15
KR100383063B1 (ko) 2003-07-07
EP0726311B1 (fr) 2004-06-30

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Free format text: TEIJIN LIMITED#6-7, MINAMIHONMACHI 1-CHOME CHUO-KU#OSAKA-SHI OSAKA 541-0054 (JP) $ JURIDICAL FOUNDATION, THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE#6-1, OKUBO 1-CHOME#KUMAMOTO-SHI, KUMAMOTO 860-8568 (JP) -TRANSFER TO- TEIJIN LIMITED#6-7, MINAMIHONMACHI 1-CHOME CHUO-KU#OSAKA-SHI OSAKA 541-0054 (JP) $ JURIDICAL FOUNDATION, THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE#6-1, OKUBO 1-CHOME#KUMAMOTO-SHI, KUMAMOTO 860-8568 (JP)

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