EP0721351A4 - Haplotype-matched cytokine-secreting cells and methods of using to stimulate an immune response - Google Patents

Haplotype-matched cytokine-secreting cells and methods of using to stimulate an immune response

Info

Publication number
EP0721351A4
EP0721351A4 EP94927393A EP94927393A EP0721351A4 EP 0721351 A4 EP0721351 A4 EP 0721351A4 EP 94927393 A EP94927393 A EP 94927393A EP 94927393 A EP94927393 A EP 94927393A EP 0721351 A4 EP0721351 A4 EP 0721351A4
Authority
EP
European Patent Office
Prior art keywords
haplotype
stimulate
methods
immune response
secreting cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94927393A
Other languages
German (de)
French (fr)
Other versions
EP0721351A1 (en
Inventor
Robert E Sobol
Ivor Royston
Habib Fakhrai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sidney Kimmel Cancer Center
Original Assignee
Sidney Kimmel Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sidney Kimmel Cancer Center filed Critical Sidney Kimmel Cancer Center
Publication of EP0721351A1 publication Critical patent/EP0721351A1/en
Publication of EP0721351A4 publication Critical patent/EP0721351A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP94927393A 1993-09-07 1994-09-06 Haplotype-matched cytokine-secreting cells and methods of using to stimulate an immune response Withdrawn EP0721351A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11838393A 1993-09-07 1993-09-07
PCT/US1994/010217 WO1995007105A1 (en) 1993-09-07 1994-09-06 Haplotype-matched cytokine-secreting cells and methods of using to stimulate an immune response
US118383 2002-04-05

Publications (2)

Publication Number Publication Date
EP0721351A1 EP0721351A1 (en) 1996-07-17
EP0721351A4 true EP0721351A4 (en) 1998-08-19

Family

ID=22378237

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94927393A Withdrawn EP0721351A4 (en) 1993-09-07 1994-09-06 Haplotype-matched cytokine-secreting cells and methods of using to stimulate an immune response

Country Status (4)

Country Link
EP (1) EP0721351A4 (en)
JP (1) JPH09504786A (en)
CA (1) CA2171211A1 (en)
WO (1) WO1995007105A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU693435B2 (en) * 1993-02-17 1998-07-02 Sloan-Kettering Institute For Cancer Research Allogeneic vaccine and method to synthesize same
US5772995A (en) 1994-07-18 1998-06-30 Sidney Kimmel Cancer Center Compositions and methods for enhanced tumor cell immunity in vivo
US5952221A (en) 1996-03-06 1999-09-14 Avigen, Inc. Adeno-associated virus vectors comprising a first and second nucleic acid sequence
DE19716098A1 (en) * 1997-04-17 1998-10-22 Univ Ludwigs Albert Fibroblasts containing a foreign gene composition for treating wounds
EP1025123B1 (en) * 1997-10-23 2009-12-16 Nikolaus W. Klehr Method for the production of human blood cytokines
EP3843758A4 (en) * 2018-08-27 2022-06-08 Figene, LLC Chimeric antigen receptor fibroblast cells for treatment of cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018995A1 (en) * 1993-02-17 1994-09-01 Sloan-Kettering Institute For Cancer Research Allogeneic vaccine and method to synthesize same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018995A1 (en) * 1993-02-17 1994-09-01 Sloan-Kettering Institute For Cancer Research Allogeneic vaccine and method to synthesize same

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
E. H. OLDFIELD ET AL: "gene therapy for the treatment of brain tumors using intra-tumoral transduction with the Thymidine kinase gene and intravenous ganciclovir", HUMAN GENE THERAPY, vol. 4, February 1993 (1993-02-01), pages 39 - 69, XP002066684 *
GANSBACHER B. E AL: "RETROVIRAL GENE TRANSFER INDUCED CONSTITUTIVE EXPRESSION OF INTERLEUKIN-2 OR INTERFERON-GAMMA IN IRRADIATED HUMAN MELANOMA CELLS", BLOOD, vol. 80, no. 11, December 1992 (1992-12-01), pages 2817 - 2825, XP002066683 *
M.D. KAWAJA ET AL: "Employment of fibroblasts for gene transfer: Application for grafting into the central nervous system", GENETIC ENGINEERING, vol. 13, 1991, EDITED BY J.K. SETLOW, PLENUM PRESS, NEW YORK, pages 205 - 220, XP002066685 *
N.J. CROWLEY ET AL: "Generation of human autologous melanoma specific cytotoxic T-cells using HLA-A2-matched allogeneic melanomas", CANCER RESEARCH, vol. 50, no. 1, 1 January 1990 (1990-01-01), pages 492 - 498, XP002066686 *
S. OSANTO ET AL: "Immunization with interleukin-2 transfected melanoma cells. A phase I-II study in patients with metastatic melanoma", HUMAN GENE THERAPY, vol. 4, June 1993 (1993-06-01), pages 323 - 330, XP002065933 *
See also references of WO9507105A1 *

Also Published As

Publication number Publication date
WO1995007105A1 (en) 1995-03-16
CA2171211A1 (en) 1995-03-16
JPH09504786A (en) 1997-05-13
EP0721351A1 (en) 1996-07-17

Similar Documents

Publication Publication Date Title
HU9302049D0 (en) Trans-splitting ribosimes and elimination of cells using them
EP0263645A3 (en) Catheters and methods of using such catheters
GB2192248A (en) Fire-stop stack fitting and method of using same
GB8701900D0 (en) Expression of genes in plants
EP0921816A4 (en) Opsonin-enhanced cells, and methods of modulating an immune response to an antigen
IL108079A0 (en) Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
EP0335630A3 (en) Switching device and method of preparing it
IL111122A0 (en) Methods of stimulating phagocytosis
IL80026A0 (en) Combination of portable seat and carrying case
EP0445227A4 (en) Position-specific insertion vectors and method of using same
IL93195A0 (en) Cyclopentenyl pyrimidines and method of using same
EP0721351A4 (en) Haplotype-matched cytokine-secreting cells and methods of using to stimulate an immune response
GB2214618B (en) Explosive devices and methods of use thereof
NZ227594A (en) Human interleukin-1alpha and preparations thereof
GB2190746B (en) Improvements in or relating to methods of collecting data and seismic vibrators
GB8923571D0 (en) Connecting means and method of use thereof
GB2248299B (en) Improvements in and relating to seismic devices
EP0686039A4 (en) Method of enhancing immune response to oral vaccines
IL106242A0 (en) Method of producing genetically modified astrocytes and uses thereof
GB8911899D0 (en) Improvements in and relating to the fitting of aerials
EP0270470A3 (en) Massage method and implement
EP0459788A3 (en) Modified proteins and methods of producing same
GB2216139B (en) Treatment of alcohol and alcoholic compositions
GB9206719D0 (en) Improvements in and relating to simulating electrical characteristics of components
CS3490A2 (en) Elastic amortisseurs and method of their production

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19960307

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 19980701

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI NL PT SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Withdrawal date: 19981001