EP0695138A4 - Stabilization of voltage sensitive dyes - Google Patents

Stabilization of voltage sensitive dyes

Info

Publication number
EP0695138A4
EP0695138A4 EP94914830A EP94914830A EP0695138A4 EP 0695138 A4 EP0695138 A4 EP 0695138A4 EP 94914830 A EP94914830 A EP 94914830A EP 94914830 A EP94914830 A EP 94914830A EP 0695138 A4 EP0695138 A4 EP 0695138A4
Authority
EP
European Patent Office
Prior art keywords
stabilization
voltage sensitive
sensitive dyes
dyes
voltage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94914830A
Other languages
German (de)
French (fr)
Other versions
EP0695138A1 (en
Inventor
Julie Beaty Nosco
Steven R Cooper
Margaret A Mcloughlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Medical Inc filed Critical Mallinckrodt Medical Inc
Publication of EP0695138A1 publication Critical patent/EP0695138A1/en
Publication of EP0695138A4 publication Critical patent/EP0695138A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0023—Di-or triarylmethane dye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0071—Process features in the making of dyestuff preparations; Dehydrating agents; Dispersing agents; Dustfree compositions
EP94914830A 1993-04-20 1994-04-19 Stabilization of voltage sensitive dyes Withdrawn EP0695138A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4993693A 1993-04-20 1993-04-20
US49936 1993-04-20
PCT/US1994/004267 WO1994023646A1 (en) 1993-04-20 1994-04-19 Stabilization of voltage sensitive dyes

Publications (2)

Publication Number Publication Date
EP0695138A1 EP0695138A1 (en) 1996-02-07
EP0695138A4 true EP0695138A4 (en) 1998-09-02

Family

ID=21962548

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94914830A Withdrawn EP0695138A4 (en) 1993-04-20 1994-04-19 Stabilization of voltage sensitive dyes

Country Status (5)

Country Link
EP (1) EP0695138A4 (en)
JP (1) JPH08509260A (en)
AU (1) AU6707694A (en)
MX (1) MXPA94002884A (en)
WO (1) WO1994023646A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5709845A (en) * 1996-05-13 1998-01-20 Rajagopalan; Raghavan Tricyclic functional dyes for contrast enhancement in optical imaging
WO1999013916A2 (en) * 1997-09-18 1999-03-25 Nycomed Imaging As Methods and compositions for medical imaging
US6944493B2 (en) * 1999-09-10 2005-09-13 Akora, Inc. Indocyanine green (ICG) compositions and related methods of use
WO2015095344A1 (en) * 2013-12-17 2015-06-25 University Of Chicago Voltage sensitive composition and method of use thereof
EP4188452A1 (en) * 2020-07-31 2023-06-07 CAO Group, Inc. Shelf-stable indocyanine green solutions and methods of making the same
EP4308082A1 (en) 2021-03-17 2024-01-24 Provepharm Life Solutions Stable formulations of indocyanine green
JP2024510501A (en) * 2021-03-17 2024-03-07 プルーヴファーム・ライフ・ソリューションズ Stable formulation of indocyanine green
WO2022194733A2 (en) 2021-03-17 2022-09-22 Provepharm Life Solutions Stable formulations of indocyanine green

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4369250A (en) * 1981-07-31 1983-01-18 Sherwood Medical Industries Inc. Fatty acid determination
US4526701A (en) * 1981-08-31 1985-07-02 Lever Brothers Company Dye stabilized detergent compositions
US4478818A (en) * 1982-12-27 1984-10-23 Alza Corporation Ocular preparation housing steroid in two different therapeutic forms
US5266302A (en) * 1990-10-03 1993-11-30 Peyman Gholam A Method of performing angiography

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9423646A1 *

Also Published As

Publication number Publication date
JPH08509260A (en) 1996-10-01
WO1994023646A1 (en) 1994-10-27
MXPA94002884A (en) 2002-06-18
EP0695138A1 (en) 1996-02-07
AU6707694A (en) 1994-11-08

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19951025

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: MCLOUGHLIN, MARGARET, A.

Inventor name: COOPER, STEVEN, R.

Inventor name: NOSCO, JULIE BEATY

A4 Supplementary search report drawn up and despatched

Effective date: 19980722

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18D Application deemed to be withdrawn

Effective date: 20000704