EP0682109A4 - Zyklische nukleotidase und verfahren zur herstellung derselben. - Google Patents
Zyklische nukleotidase und verfahren zur herstellung derselben.Info
- Publication number
- EP0682109A4 EP0682109A4 EP94905225A EP94905225A EP0682109A4 EP 0682109 A4 EP0682109 A4 EP 0682109A4 EP 94905225 A EP94905225 A EP 94905225A EP 94905225 A EP94905225 A EP 94905225A EP 0682109 A4 EP0682109 A4 EP 0682109A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- nucleotidase
- cyclic
- producing
- same
- cgmp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 125000004122 cyclic group Chemical group 0.000 title abstract 2
- 108010028584 nucleotidase Proteins 0.000 title abstract 2
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 2
- RQFCJASXJCIDSX-UHFFFAOYSA-N 14C-Guanosin-5'-monophosphat Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(COP(O)(O)=O)C(O)C1O RQFCJASXJCIDSX-UHFFFAOYSA-N 0.000 abstract 1
- AEOBEOJCBAYXBA-UHFFFAOYSA-N A2P5P Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1OP(O)(O)=O AEOBEOJCBAYXBA-UHFFFAOYSA-N 0.000 abstract 1
- 108010044467 Isoenzymes Proteins 0.000 abstract 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- RQFCJASXJCIDSX-UUOKFMHZSA-N guanosine 5'-monophosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O RQFCJASXJCIDSX-UUOKFMHZSA-N 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1315093 | 1993-01-29 | ||
JP13150/93 | 1993-01-29 | ||
PCT/JP1994/000121 WO1994017181A1 (en) | 1993-01-29 | 1994-01-28 | Cyclic nucleotidase and process for producing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0682109A1 EP0682109A1 (de) | 1995-11-15 |
EP0682109A4 true EP0682109A4 (de) | 1997-06-04 |
Family
ID=11825144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94905225A Ceased EP0682109A4 (de) | 1993-01-29 | 1994-01-28 | Zyklische nukleotidase und verfahren zur herstellung derselben. |
Country Status (6)
Country | Link |
---|---|
US (1) | US5728563A (de) |
EP (1) | EP0682109A4 (de) |
KR (1) | KR960700338A (de) |
AU (1) | AU669969B2 (de) |
CA (1) | CA2153265A1 (de) |
WO (1) | WO1994017181A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5858694A (en) * | 1997-05-30 | 1999-01-12 | Cell Pathways, Inc. | Method for identifying compounds for inhibition of cancerous lesions |
CA2238283C (en) | 1997-05-30 | 2002-08-20 | Cell Pathways, Inc. | Method for identifying compounds for inhibition of neoplastic lesions, pharmaceutical compositions from such compounds and uses of such compounds and compositions for treating neoplastic lesions |
US6410584B1 (en) * | 1998-01-14 | 2002-06-25 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells with indole derivatives |
EP0980911A3 (de) * | 1998-06-04 | 2000-04-05 | Bayer Ag | Phosphodiesterase |
US6130053A (en) * | 1999-08-03 | 2000-10-10 | Cell Pathways, Inc. | Method for selecting compounds for inhibition of neoplastic lesions |
US6200771B1 (en) | 1998-10-15 | 2001-03-13 | Cell Pathways, Inc. | Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia |
US6133271A (en) * | 1998-11-19 | 2000-10-17 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives |
US6187779B1 (en) | 1998-11-20 | 2001-02-13 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives |
US6369092B1 (en) | 1998-11-23 | 2002-04-09 | Cell Pathways, Inc. | Method for treating neoplasia by exposure to substituted benzimidazole derivatives |
US6077842A (en) * | 1998-11-24 | 2000-06-20 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives |
US6034099A (en) * | 1998-11-24 | 2000-03-07 | Cell Pathways, Inc. | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones |
US6486155B1 (en) | 1998-11-24 | 2002-11-26 | Cell Pathways Inc | Method of inhibiting neoplastic cells with isoquinoline derivatives |
US6025394A (en) | 1999-01-29 | 2000-02-15 | Cell Pathways, Inc. | Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols |
US6020379A (en) * | 1999-02-19 | 2000-02-01 | Cell Pathways, Inc. | Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia |
US6555547B1 (en) | 2000-02-28 | 2003-04-29 | Cell Pathways, Inc. | Method for treating a patient with neoplasia by treatment with a vinca alkaloid derivative |
US6569638B1 (en) | 2000-03-03 | 2003-05-27 | Cell Pathways, Inc | Method for screening compounds for the treatment of neoplasia |
US20080075785A1 (en) * | 2006-09-22 | 2008-03-27 | San-Laung Chow | Controlled release hydrogel formulation |
US20110165236A1 (en) * | 2006-09-22 | 2011-07-07 | Biokey, Inc. | Controlled release hydrogel formulation |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992018541A1 (en) * | 1991-04-19 | 1992-10-29 | The Board Of Regents Of The University Of Washington | Dna encoding mammalian phosphodiesterases |
-
1994
- 1994-01-28 WO PCT/JP1994/000121 patent/WO1994017181A1/ja not_active Application Discontinuation
- 1994-01-28 EP EP94905225A patent/EP0682109A4/de not_active Ceased
- 1994-01-28 AU AU58916/94A patent/AU669969B2/en not_active Ceased
- 1994-01-28 CA CA002153265A patent/CA2153265A1/en not_active Abandoned
- 1994-01-28 KR KR1019950702740A patent/KR960700338A/ko not_active Application Discontinuation
- 1994-01-28 US US08/481,442 patent/US5728563A/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992018541A1 (en) * | 1991-04-19 | 1992-10-29 | The Board Of Regents Of The University Of Washington | Dna encoding mammalian phosphodiesterases |
Non-Patent Citations (3)
Title |
---|
MUKAI J ET AL: "ISOLATION AND DRUG SENSITIVITY OF NOVEL CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ISOZYME IN RAT CEREBRUM.", 66TH ANNUAL MEETING OF THE JAPANESE PHARMACOLOGICAL SOCIETY, YOKOHAMA, JAPAN, MARCH 24-27, 1993. JPN J PHARMACOL 61 (SUPPL. 1). 1993. 329P. CODEN: JJPAAZ ISSN: 0021-5198, XP000670722 * |
MUKAI, JUN ET AL: "Separation and characterization of a novel isoenzyme of cyclic nucleotide phosphodiesterase from rat cerebrum", BR. J. PHARMACOL. (1994), 111(2), 389-90 CODEN: BJPCBM;ISSN: 0007-1188, 1994, XP000670714 * |
See also references of WO9417181A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU669969B2 (en) | 1996-06-27 |
CA2153265A1 (en) | 1994-08-04 |
US5728563A (en) | 1998-03-17 |
EP0682109A1 (de) | 1995-11-15 |
WO1994017181A1 (en) | 1994-08-04 |
AU5891694A (en) | 1994-08-15 |
KR960700338A (ko) | 1996-01-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19950710 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19970423 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
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GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
17Q | First examination report despatched |
Effective date: 20000907 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
|
18R | Application refused |
Effective date: 20010416 |