EP0675723A4 - Bisphosphonate/estrogen therapy for treating and preventing bone loss. - Google Patents
Bisphosphonate/estrogen therapy for treating and preventing bone loss.Info
- Publication number
- EP0675723A4 EP0675723A4 EP94905419A EP94905419A EP0675723A4 EP 0675723 A4 EP0675723 A4 EP 0675723A4 EP 94905419 A EP94905419 A EP 94905419A EP 94905419 A EP94905419 A EP 94905419A EP 0675723 A4 EP0675723 A4 EP 0675723A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- bisphosphonate
- treating
- bone loss
- preventing bone
- estrogen therapy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99641892A | 1992-12-23 | 1992-12-23 | |
PCT/US1993/012302 WO1994014455A1 (en) | 1992-12-23 | 1993-12-17 | Bisphosphonate/estrogen therapy for treating and preventing bone loss |
US996418 | 1997-12-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0675723A1 EP0675723A1 (en) | 1995-10-11 |
EP0675723A4 true EP0675723A4 (en) | 1998-08-05 |
Family
ID=25542895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94905419A Ceased EP0675723A4 (en) | 1992-12-23 | 1993-12-17 | Bisphosphonate/estrogen therapy for treating and preventing bone loss. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0675723A4 (en) |
JP (1) | JPH08505142A (en) |
AU (1) | AU5953894A (en) |
CA (1) | CA2151240A1 (en) |
WO (1) | WO1994014455A1 (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5650168A (en) * | 1993-05-15 | 1997-07-22 | Boehringer Mannheim Gmbh | Tablet with improved bioavailability containing dichloromethylenediphosphonic acid as the active substance |
US5646134A (en) * | 1994-04-21 | 1997-07-08 | Merck & Co., Inc. | Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices |
NZ272608A (en) * | 1994-07-22 | 2000-05-26 | Lilly Co Eli | Inhibiting bone loss by administering a bisphosphonate and a second compound selected from various compounds, including 2-phenyl-3-aroylbenzothienes; bisphosphonate combination salts |
US5780455A (en) * | 1994-08-24 | 1998-07-14 | Merck & Co., Inc. | Intravenous alendronate formulations |
JPH10506638A (en) * | 1995-05-12 | 1998-06-30 | メルク エンド カンパニー インコーポレーテッド | Prevention of tooth loss by administration of alendronate or its salt |
US5545635A (en) * | 1995-05-23 | 1996-08-13 | Eli Lilly And Company | Inhibiting bone loss with equilenin |
US5616571A (en) * | 1995-06-06 | 1997-04-01 | Merck & Co., Inc. | Bisphosphonates prevent bone loss associated with immunosuppressive therapy |
IL120265A0 (en) * | 1996-02-28 | 1997-06-10 | Pfizer | Combination therapy to treat osteoporosis - polyphosphonates or progestins and estrogen agonists |
IL120270A0 (en) * | 1996-02-28 | 1997-06-10 | Pfizer | Combination therapy to treat osteoporosis |
DE69726879T2 (en) * | 1996-05-17 | 2004-10-14 | Merck & Co., Inc. | BIPHOSPHONATE FORMULATION WITH EFFECT |
EP1378234A1 (en) * | 1996-05-17 | 2004-01-07 | MERCK & CO. INC. | Effervescent bisphosphonate formulation |
US5853759A (en) * | 1996-05-17 | 1998-12-29 | Merck & Co.. Inc. | Effervescent alendronate formulation |
US6376477B2 (en) | 1996-11-25 | 2002-04-23 | Merck & Co., Inc. | Combination of an agent that binds to the androgen receptor and a bisphosphonic acid in the prevention and/or treatment of diseases involving calcium or phosphate metabolism |
EP0949928A4 (en) * | 1996-11-25 | 2000-09-13 | Merck & Co Inc | Androgenic and bisphosphonic agents coadministered to treat diseases |
DE19719680A1 (en) | 1997-05-09 | 1998-11-19 | Boehringer Mannheim Gmbh | Use of diphosphonic acids for the preventive treatment of long-term consequences of bladder enlargement or replacement |
US6555529B1 (en) * | 1997-12-25 | 2003-04-29 | Toray Industries, Inc. | Remedies for intramedullary diseases |
DK1135140T3 (en) * | 1998-12-04 | 2005-12-19 | Roche Diagnostics Gmbh | Ibandronic acid to promote osseointegration of endoprostheses |
EP1210138A4 (en) * | 1999-04-22 | 2003-05-07 | Hydro Med Sciences Inc | Controlled delivery of bisphosphonates |
AUPQ232599A0 (en) * | 1999-08-19 | 1999-09-09 | Royal Alexandra Hospital For Children, The | Drug for treating fractures |
FR2803521B1 (en) | 2000-01-12 | 2002-10-25 | Ceva Sante Animale | USE OF TILUDRONIC ACID AND ITS DERIVATIVES IN POULTRY FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR PREVENTING AND TREATING OSTEOPOROSIS |
CA2435552C (en) | 2001-02-06 | 2010-04-27 | The Royal Alexandra Hospital For Children | A drug for the treatment of osteonecrosis and for the management of patients at risk of developing osteonecrosis |
WO2002080933A1 (en) * | 2001-04-03 | 2002-10-17 | The Royal Alexandra Hospital For Children | A drug for use in bone grafting |
AUPR553701A0 (en) * | 2001-06-07 | 2001-07-12 | Royal Alexandra Hospital For Children, The | A device for the delivery of a drug to a fractured bone |
TWI315982B (en) | 2001-07-19 | 2009-10-21 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
NZ534104A (en) | 2001-12-24 | 2007-03-30 | Teva Pharma | Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material |
US7488496B2 (en) | 2002-03-06 | 2009-02-10 | Christer Rosen | Effervescent compositions comprising bisphosphonates and methods related thereto |
ES2561463T3 (en) * | 2003-08-21 | 2016-02-26 | Addbio Ab | Implant device coated with bisphosphonate and method for it |
WO2007048264A1 (en) * | 2005-10-27 | 2007-05-03 | Thommen Medical Ag | Dental implant and production method for said implant |
US8882740B2 (en) | 2009-12-23 | 2014-11-11 | Stryker Trauma Gmbh | Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992005187A1 (en) * | 1990-09-18 | 1992-04-02 | Boehringer Mannheim Gmbh | NEW 17-β-OESTRADIOL DERIVATIVES, A METHOD OF PREPARING THEM, AND DRUGS CONTAINING THEM |
EP0496520A1 (en) * | 1991-01-22 | 1992-07-29 | Merck & Co. Inc. | Novel bone acting agents |
WO1992014474A1 (en) * | 1991-02-26 | 1992-09-03 | Norwich Eaton Pharmaceuticals, Inc. | Methods for the treatment of osteoporosis |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3623397A1 (en) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | NEW DIPHOSPHONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
-
1993
- 1993-12-17 WO PCT/US1993/012302 patent/WO1994014455A1/en not_active Application Discontinuation
- 1993-12-17 JP JP6515312A patent/JPH08505142A/en active Pending
- 1993-12-17 EP EP94905419A patent/EP0675723A4/en not_active Ceased
- 1993-12-17 AU AU59538/94A patent/AU5953894A/en not_active Abandoned
- 1993-12-17 CA CA002151240A patent/CA2151240A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992005187A1 (en) * | 1990-09-18 | 1992-04-02 | Boehringer Mannheim Gmbh | NEW 17-β-OESTRADIOL DERIVATIVES, A METHOD OF PREPARING THEM, AND DRUGS CONTAINING THEM |
EP0496520A1 (en) * | 1991-01-22 | 1992-07-29 | Merck & Co. Inc. | Novel bone acting agents |
WO1992014474A1 (en) * | 1991-02-26 | 1992-09-03 | Norwich Eaton Pharmaceuticals, Inc. | Methods for the treatment of osteoporosis |
Non-Patent Citations (2)
Title |
---|
CIMINERA N. ET AL: "Studio Comparativo degli effeti di estrogeni e difosfonati sulla perdita ossea postmenopausale", ANN. OSTET. GINECOL. MED. PERINAT., vol. 113, no. 5, 1992, pages 232 - 237, XP002064831 * |
See also references of WO9414455A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP0675723A1 (en) | 1995-10-11 |
CA2151240A1 (en) | 1994-07-07 |
AU5953894A (en) | 1994-07-19 |
WO1994014455A1 (en) | 1994-07-07 |
JPH08505142A (en) | 1996-06-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19950724 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19980619 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE |
|
17Q | First examination report despatched |
Effective date: 19981008 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
|
18R | Application refused |
Effective date: 20031106 |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1009249 Country of ref document: HK |