EP0660925A4 - Alkoxyamide derivatized chelates for mri. - Google Patents

Alkoxyamide derivatized chelates for mri.

Info

Publication number
EP0660925A4
EP0660925A4 EP19920902010 EP92902010A EP0660925A4 EP 0660925 A4 EP0660925 A4 EP 0660925A4 EP 19920902010 EP19920902010 EP 19920902010 EP 92902010 A EP92902010 A EP 92902010A EP 0660925 A4 EP0660925 A4 EP 0660925A4
Authority
EP
European Patent Office
Prior art keywords
alkoxyamide
chelates
derivatized
mri
derivatized chelates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19920902010
Other languages
German (de)
French (fr)
Other versions
EP0660925A1 (en
Inventor
Raghavan Rajagopalan
Rebecca A Wallace
Muthanadar P Periasamy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Medical Inc filed Critical Mallinckrodt Medical Inc
Publication of EP0660925A4 publication Critical patent/EP0660925A4/en
Publication of EP0660925A1 publication Critical patent/EP0660925A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Epidemiology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP92902010A 1990-11-21 1991-11-12 Alkoxyamide derivatized chelates for mri Withdrawn EP0660925A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61645990A 1990-11-21 1990-11-21
US616459 1990-11-21
PCT/US1991/008431 WO1992009884A1 (en) 1990-11-21 1991-11-12 Alkoxyamide derivatized chelates for mri

Publications (2)

Publication Number Publication Date
EP0660925A4 true EP0660925A4 (en) 1994-02-02
EP0660925A1 EP0660925A1 (en) 1995-07-05

Family

ID=24469557

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92902010A Withdrawn EP0660925A1 (en) 1990-11-21 1991-11-12 Alkoxyamide derivatized chelates for mri

Country Status (5)

Country Link
EP (1) EP0660925A1 (en)
JP (1) JPH06502858A (en)
AU (1) AU656355B2 (en)
CA (1) CA2096543A1 (en)
WO (1) WO1992009884A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007653A1 (en) * 1993-09-14 1995-03-23 The University Of Toledo Second sphere complexes as relaxation agents for image enhancement in magnetic resonance imaging
US6693190B1 (en) 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
US6294152B1 (en) 1999-01-11 2001-09-25 The University Of Toledo Iron(III) complexes as contrast agents for image enhancement in magnetic resonance imaging
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
JP7034160B2 (en) 2016-11-28 2022-03-11 バイエル・ファルマ・アクティエンゲゼルシャフト High relaxation gadolinium chelate compound for use in magnetic resonance imaging
PE20211471A1 (en) 2018-11-23 2021-08-05 Bayer Ag FORMULATION OF CONTRAST MEANS AND PROCESS TO PREPARE THEM

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0255471A1 (en) * 1986-07-28 1988-02-03 Schering Aktiengesellschaft 1,4,7,10-Tetraazacyclododecane-derivatives
WO1990001024A1 (en) * 1988-07-19 1990-02-08 Mallinckrodt, Inc. Novel magnetic resonance imaging agents
WO1990003804A1 (en) * 1988-09-27 1990-04-19 Salutar, Inc. Chelate compositions
WO1991003261A1 (en) * 1989-09-05 1991-03-21 Mallinckrodt, Inc. Novel magnetic resonance imaging agents
WO1992002259A1 (en) * 1990-08-03 1992-02-20 Mallinckrodt Medical, Inc. Novel compositions for magnetic resonance imaging
WO1993002045A1 (en) * 1991-07-17 1993-02-04 Nycomed Salutar, Inc. Hydroxamate and hydrazide derivatives of polyamines and their medical use as chelating agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4826673A (en) * 1985-01-09 1989-05-02 Mallinckrodt, Inc. Methods and compositions for enhancing magnetic resonance imaging
JPS61196319A (en) * 1985-02-27 1986-08-30 Hitachi Ltd Menu selection system of display device
JPS62293339A (en) * 1986-06-12 1987-12-19 Mitsubishi Electric Corp Method for transforming menu into hierarchy in computer system
JPH01144760A (en) * 1987-11-30 1989-06-07 Ricoh Co Ltd Composite system
JPH01191559A (en) * 1988-01-27 1989-08-01 Nec Corp Complex terminal system

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0255471A1 (en) * 1986-07-28 1988-02-03 Schering Aktiengesellschaft 1,4,7,10-Tetraazacyclododecane-derivatives
WO1990001024A1 (en) * 1988-07-19 1990-02-08 Mallinckrodt, Inc. Novel magnetic resonance imaging agents
WO1990003804A1 (en) * 1988-09-27 1990-04-19 Salutar, Inc. Chelate compositions
WO1991003261A1 (en) * 1989-09-05 1991-03-21 Mallinckrodt, Inc. Novel magnetic resonance imaging agents
WO1992002259A1 (en) * 1990-08-03 1992-02-20 Mallinckrodt Medical, Inc. Novel compositions for magnetic resonance imaging
WO1993002045A1 (en) * 1991-07-17 1993-02-04 Nycomed Salutar, Inc. Hydroxamate and hydrazide derivatives of polyamines and their medical use as chelating agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. CHEM. SOC. PERKIN TRANS. 2 August 1990, pages 1425 - 1432 R. KATAKY ET AL. 'SYNTHESIS AND BINDING PROPERTIES OF AMIDE-FUNCTIONALISED POLYAZA MACROCYCLES' * *
See also references of WO9209884A1 *

Also Published As

Publication number Publication date
JPH06502858A (en) 1994-03-31
WO1992009884A1 (en) 1992-06-11
AU656355B2 (en) 1995-02-02
AU9081091A (en) 1992-06-25
CA2096543A1 (en) 1992-05-22
EP0660925A1 (en) 1995-07-05

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19930525

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

17Q First examination report despatched

Effective date: 19991228

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20000509