EP0659085A4 - Method of inhibiting cell proliferation using apolipoprotein e. - Google Patents

Method of inhibiting cell proliferation using apolipoprotein e.

Info

Publication number
EP0659085A4
EP0659085A4 EP93919995A EP93919995A EP0659085A4 EP 0659085 A4 EP0659085 A4 EP 0659085A4 EP 93919995 A EP93919995 A EP 93919995A EP 93919995 A EP93919995 A EP 93919995A EP 0659085 A4 EP0659085 A4 EP 0659085A4
Authority
EP
European Patent Office
Prior art keywords
apolipoprotein
cell proliferation
inhibiting cell
inhibiting
proliferation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93919995A
Other languages
German (de)
French (fr)
Other versions
EP0659085A1 (en
Inventor
Tikva Vogel
Amos Panet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Savient Pharmaceuticals Inc
Original Assignee
Savient Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Savient Pharmaceuticals Inc filed Critical Savient Pharmaceuticals Inc
Publication of EP0659085A1 publication Critical patent/EP0659085A1/en
Publication of EP0659085A4 publication Critical patent/EP0659085A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP93919995A 1992-08-12 1993-08-12 Method of inhibiting cell proliferation using apolipoprotein e. Withdrawn EP0659085A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92897992A 1992-08-12 1992-08-12
US928979 1992-08-12
PCT/US1993/007582 WO1994004178A1 (en) 1992-08-12 1993-08-12 Method of inhibiting cell proliferation using apolipoprotein e

Publications (2)

Publication Number Publication Date
EP0659085A1 EP0659085A1 (en) 1995-06-28
EP0659085A4 true EP0659085A4 (en) 1996-06-12

Family

ID=25457115

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93919995A Withdrawn EP0659085A4 (en) 1992-08-12 1993-08-12 Method of inhibiting cell proliferation using apolipoprotein e.

Country Status (9)

Country Link
EP (1) EP0659085A4 (en)
JP (1) JPH08502730A (en)
KR (1) KR950702430A (en)
AU (1) AU673543B2 (en)
CA (1) CA2141598A1 (en)
IL (1) IL106664A0 (en)
NZ (1) NZ255732A (en)
WO (1) WO1994004178A1 (en)
ZA (1) ZA935879B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
CA2167942A1 (en) * 1993-08-12 1995-02-23 Tikva Vogel Method of inhibiting kaposi's sarcoma
IL120005A (en) * 1997-01-14 2000-08-31 Ramot University Authority Of Pharmaceutical compositions for the treatment of the eye
US6593291B1 (en) * 1997-02-06 2003-07-15 Entremed, Inc. Compositions and methods of use of ligands that bind components of the blood coagulation/clotting pathway for the treatment of cancer and angiogenic-based disease
WO2000054801A1 (en) * 1999-03-17 2000-09-21 Entremed, Inc. Compositions and methods of use of ldl-like receptor ligands for the treatment of cancer and angiogenic-based disease
WO2001037853A2 (en) * 1999-11-23 2001-05-31 North Shore - Long Island Jewish Health System Methods and agents for the inhibition of smooth muscle cell proliferation
US20020182587A1 (en) * 2001-03-02 2002-12-05 Sivaram Pillarisetti Methods and compositions for the treatment and prevention of smooth muscle cell proliferation
EP2303304A4 (en) * 2008-07-01 2011-09-21 Cognosci Inc Methods of treating cancer with apoe peptides
CN102917727B (en) 2010-01-06 2017-10-17 康石医药科技（上海）有限公司 APOE peptides and application thereof
WO2013042684A1 (en) * 2011-09-20 2013-03-28 国立大学法人熊本大学 Prophylactic and therapeutic agent for neurological diseases using lipoproteins and prophylactic and therapeutic method for neurological diseases
EP4215214A4 (en) * 2020-09-16 2024-07-03 Univ Osaka Cancer therapeutic agent, immunostimulant and screening method for anticancer substance

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002751A1 (en) * 1989-08-18 1991-03-07 Scripps Clinic And Research Foundation Polypeptide analogs of apolipoprotein e, diagnostic systems and methods using the analogs
WO1992010512A1 (en) * 1990-12-10 1992-06-25 The Scripps Research Institute Polypeptide analogs of apolipoprotein e, diagnostic systems and methods using the analogs
WO1995005190A1 (en) * 1993-08-12 1995-02-23 Bio-Technology General Corp. Method of inhibiting kaposi's sarcoma

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0600875A4 (en) * 1991-06-26 1995-01-25 Bio Technology General Corp Purification of recombinant apolipoprotein e from bacteria.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002751A1 (en) * 1989-08-18 1991-03-07 Scripps Clinic And Research Foundation Polypeptide analogs of apolipoprotein e, diagnostic systems and methods using the analogs
WO1992010512A1 (en) * 1990-12-10 1992-06-25 The Scripps Research Institute Polypeptide analogs of apolipoprotein e, diagnostic systems and methods using the analogs
WO1995005190A1 (en) * 1993-08-12 1995-02-23 Bio-Technology General Corp. Method of inhibiting kaposi's sarcoma

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DYER ET AL: "ONLY MULTIMERS OF A SYNTHETIC PEPTIDE OF HUMAN APOLIPOPROTEIN E ARE BIOLOGICALLY ACTIVE", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 23, 15 August 1991 (1991-08-15), pages 15009 - 15015 *
See also references of WO9404178A1 *

Also Published As

Publication number Publication date
JPH08502730A (en) 1996-03-26
CA2141598A1 (en) 1994-03-03
EP0659085A1 (en) 1995-06-28
IL106664A0 (en) 1993-12-08
NZ255732A (en) 1997-05-26
KR950702430A (en) 1995-07-29
AU673543B2 (en) 1996-11-14
ZA935879B (en) 1994-03-11
WO1994004178A1 (en) 1994-03-03
AU5007293A (en) 1994-03-15

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19950310

AK Designated contracting states

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RHK1 Main classification (correction)

Ipc: A61K 38/00

RHK1 Main classification (correction)

Ipc: A61K 37/02

A4 Supplementary search report drawn up and despatched

Effective date: 19960419

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18W Application withdrawn

Withdrawal date: 19970610