EP0644869A4 - Ion pairs of hypericin compounds having antiviral activity. - Google Patents

Ion pairs of hypericin compounds having antiviral activity.

Info

Publication number
EP0644869A4
EP0644869A4 EP93906002A EP93906002A EP0644869A4 EP 0644869 A4 EP0644869 A4 EP 0644869A4 EP 93906002 A EP93906002 A EP 93906002A EP 93906002 A EP93906002 A EP 93906002A EP 0644869 A4 EP0644869 A4 EP 0644869A4
Authority
EP
European Patent Office
Prior art keywords
hypericin
compounds
antiviral activity
ion pairs
pairs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93906002A
Other versions
EP0644869A1 (en
Inventor
Yehuda Mazur
Daniel Meruelo
Gad Lavie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
New York University NYU
Original Assignee
Yeda Research and Development Co Ltd
New York University NYU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd, New York University NYU filed Critical Yeda Research and Development Co Ltd
Publication of EP0644869A1 publication Critical patent/EP0644869A1/en
Publication of EP0644869A4 publication Critical patent/EP0644869A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/36—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having four or more rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
    • A01N35/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B3/00—Dyes with an anthracene nucleus condensed with one or more carbocyclic rings
    • C09B3/78—Other dyes in which the anthracene nucleus is condensed with one or more carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/02—Dyestuff salts, e.g. salts of acid dyes with basic dyes
    • C09B69/04—Dyestuff salts, e.g. salts of acid dyes with basic dyes of anionic dyes with nitrogen containing compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP93906002A 1992-02-14 1993-02-16 Ion pairs of hypericin compounds having antiviral activity. Withdrawn EP0644869A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83589692A 1992-02-14 1992-02-14
US835896 1992-02-14
PCT/US1993/001393 WO1993015607A1 (en) 1992-02-14 1993-02-16 Ion pairs of hypericin compounds having antiviral activity

Publications (2)

Publication Number Publication Date
EP0644869A1 EP0644869A1 (en) 1995-03-29
EP0644869A4 true EP0644869A4 (en) 1995-04-12

Family

ID=25270742

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93906002A Withdrawn EP0644869A4 (en) 1992-02-14 1993-02-16 Ion pairs of hypericin compounds having antiviral activity.

Country Status (6)

Country Link
EP (1) EP0644869A4 (en)
JP (1) JPH07504170A (en)
AU (1) AU679676B2 (en)
CA (1) CA2130090A1 (en)
IL (1) IL104693A0 (en)
WO (1) WO1993015607A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL121440A0 (en) 1997-07-31 1998-01-04 Yeda Res & Dev The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
US20080199458A1 (en) * 2007-01-19 2008-08-21 Jian-Er Lin Influenza prevention and treatment composition
WO2011104667A1 (en) * 2010-02-25 2011-09-01 Anthem Biosciences Private Limited Basic aminoacid salts of polyphenols
WO2017151111A1 (en) * 2016-03-01 2017-09-08 Soligenix, Inc. Systems and methods for producing synthetic hypericin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4898891A (en) * 1987-08-07 1990-02-06 Yeda Research And Development Company Ltd. Antiviral compositions
WO1993008797A1 (en) * 1991-11-01 1993-05-13 New York University Hypericin compositions for treating t-cell mediated diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4898891A (en) * 1987-08-07 1990-02-06 Yeda Research And Development Company Ltd. Antiviral compositions
WO1993008797A1 (en) * 1991-11-01 1993-05-13 New York University Hypericin compositions for treating t-cell mediated diseases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 118, no. 1, 4 January 1993, Columbus, Ohio, US; abstract no. 006783, WEINER L ET AL: "EPR studies of hypericin. Photogeneration of free radicals and superoxide" *
CHEMICAL ABSTRACTS, vol. 118, no. 15, 12 April 1993, Columbus, Ohio, US; abstract no. 143391, FALK H ET AL: "The Nature of "Soluble" Hypericin in Hypericum species" *
J. CHEM. SOC., PERKIN TRANS. 2 (JCPKBH,03009580);92; (9); PP.1439-42, WEIZMANN INST. SCI.;DEP. CHEM. PHYS.; REHOVOT; 76 100; ISRAEL (IL) *
MONATSH. CHEM. (MOCMB7,00269247);92; VOL.123 (8-9); PP.731-9, JOHANNES-KEPLER-UNIV.;INST. CHEM.; LINZ; A-4040; AUSTRIA (AT) *
See also references of WO9315607A1 *

Also Published As

Publication number Publication date
AU679676B2 (en) 1997-07-10
EP0644869A1 (en) 1995-03-29
CA2130090A1 (en) 1993-08-19
JPH07504170A (en) 1995-05-11
AU3720593A (en) 1993-09-03
IL104693A0 (en) 1993-06-10
WO1993015607A1 (en) 1993-08-19

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Legal Events

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Effective date: 19971111