EP0584208A4 - - Google Patents

Info

Publication number
EP0584208A4
EP0584208A4 EP19920911583 EP92911583A EP0584208A4 EP 0584208 A4 EP0584208 A4 EP 0584208A4 EP 19920911583 EP19920911583 EP 19920911583 EP 92911583 A EP92911583 A EP 92911583A EP 0584208 A4 EP0584208 A4 EP 0584208A4
Authority
EP
Grant status
Application
Patent type
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19920911583
Other versions
EP0584208A1 (en )
Inventor
Paul Elliot Bender
Siegfried Benjamin Christensen, Iv
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
EP19920911583 1991-05-02 1992-05-01 Withdrawn EP0584208A4 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US69462491 true 1991-05-02 1991-05-02
US694624 1991-05-02

Publications (2)

Publication Number Publication Date
EP0584208A1 true EP0584208A1 (en) 1994-03-02
EP0584208A4 true true EP0584208A4 (en) 1994-03-23

Family

ID=24789624

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19920911583 Withdrawn EP0584208A4 (en) 1991-05-02 1992-05-01

Country Status (5)

Country Link
EP (1) EP0584208A4 (en)
JP (1) JPH06507405A (en)
CN (1) CN1067244A (en)
CA (1) CA2102106A1 (en)
WO (1) WO1992019594A1 (en)

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US5665737B1 (en) * 1994-10-12 1999-02-16 Euro Celtique Sa Substituted benzoxazoles
DE69531506D1 (en) * 1994-12-13 2003-09-18 Euro Celtique Sa Arylthioxanthine
CN1173818A (en) * 1995-02-10 1998-02-18 舍林股份公司 Pharmaceutical preparations for tumour necrosis factor (TNF) inhibition
US6268373B1 (en) 1995-06-07 2001-07-31 Euro-Celtique S.A. Trisubstituted thioxanthines
US5658940A (en) * 1995-10-06 1997-08-19 Celgene Corporation Succinimide and maleimide cytokine inhibitors
DE19540475A1 (en) * 1995-10-20 1997-04-24 Schering Ag chiral methylphenyloxazolidinones
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GB9526245D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
GB9526246D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
GB9608435D0 (en) * 1996-04-24 1996-06-26 Celltech Therapeutics Ltd Chemical compounds
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US5744473A (en) * 1996-09-16 1998-04-28 Euro-Celtique, S.A. PDE IV inhibitors: "bis-compounds"
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
GB9622363D0 (en) 1996-10-28 1997-01-08 Celltech Therapeutics Ltd Chemical compounds
GB9625184D0 (en) * 1996-12-04 1997-01-22 Celltech Therapeutics Ltd Chemical compounds
US6057329A (en) * 1996-12-23 2000-05-02 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives
GB9705361D0 (en) 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
WO1998042666A1 (en) * 1997-03-21 1998-10-01 Daewoong Pharmaceutical Co., Ltd. Novel 3,4-dialkoxyphenyl derivatives and the use thereof
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
GB9914258D0 (en) 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
GB9924862D0 (en) 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
US6680336B2 (en) 1999-12-15 2004-01-20 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
US6372777B1 (en) 1999-12-23 2002-04-16 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
US6348602B1 (en) 1999-12-23 2002-02-19 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
US6376489B1 (en) 1999-12-23 2002-04-23 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
KR100755103B1 (en) * 2000-01-06 2007-09-04 사노피-아벤티스 Novel Tetrahydropyridines, Preparation Method and Pharmaceutical Compositions Containing Same
FR2803593B1 (en) 2000-01-06 2002-02-15 Sanofi Synthelabo News tetrahydropyridine, process for their preparation and pharmaceutical compositions containing them
EP2258689A1 (en) 2000-03-16 2010-12-08 Biolipox AB Benzylated PDE4 inhibitors
US7169808B2 (en) 2000-06-23 2007-01-30 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity
WO2002081446A1 (en) * 2001-04-06 2002-10-17 Daewoong Co., Ltd. 3-cyclopentyloxy-4-methoxyphenyl-isoindolinone derivatives and the use thereof
WO2002081447A1 (en) * 2001-04-06 2002-10-17 Daewoong Pharmaceutical Co., Ltd. 3-cyclopentyloxy-4-methoxyphenyl-isothiazolinone derivatives and the use thereof
FR2823748B1 (en) * 2001-04-20 2004-02-20 Sanofi Synthelabo Tetrahydropyridyl-alkyl benzodiazines, process for their preparation and pharmaceutical compositions containing them
CN100480242C (en) 2001-05-29 2009-04-22 舍林股份公司 CDK-inhibitory pyrimidines, and production and use thereof as pharmaceutical agents
CA2463469A1 (en) 2001-10-16 2003-04-24 Memory Pharmaceuticals Corporation 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes
WO2004011429A1 (en) * 2002-07-26 2004-02-05 Nihon Nohyaku Co., Ltd. Novel haloalkylsulfonanilide derivatives, herbicides and usage thereof
JP2004107323A (en) * 2002-07-26 2004-04-08 Nippon Nohyaku Co Ltd New haloalkylsulfone anilide derivative, herbicide and use thereof
CN100439337C (en) 2002-11-26 2008-12-03 辉瑞产品公司 Phenyl substituted piperidine compounds for use as PPAR activators
JP2006523710A (en) 2003-04-16 2006-10-19 エフ.ホフマン ラ−ロシュ インコーポレイティド Phosphodiesterase 4 inhibitor
EP1631568A1 (en) 2003-04-18 2006-03-08 Memory Pharmaceuticals Corporation Pyrazole derivatives as phosphodiesterase 4 inhibitors
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JPWO2006041121A1 (en) * 2004-10-13 2008-05-15 協和醗酵工業株式会社 Of chronic skin diseases and / or prophylactic agent
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CN101166733A (en) 2004-10-15 2008-04-23 记忆药物公司 Pyrazole derivatives as phosphodiesterase 4 inhibitors
CN101166737A (en) 2004-10-20 2008-04-23 记忆药物公司 Phosphodiesterase 4 inhibitors
ES2394453T3 (en) 2004-10-22 2013-01-31 Novartis Ag Purine derivatives for use as adenosine receptor agonists A-2A
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
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US7517870B2 (en) 2004-12-03 2009-04-14 Fondazione Telethon Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
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KR20080049113A (en) 2005-10-21 2008-06-03 노파르티스 아게 Human antibodies against il-13 and therapeutic uses
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GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
ES2440317T3 (en) 2006-04-21 2014-01-28 Novartis Ag Purine derivatives for use as agonists of A2A adenosine receptor
CN101516885A (en) 2006-09-29 2009-08-26 诺瓦提斯公司 Pyrazolopyrimidines as PI3K lipid kinase inhibitors
RU2009120389A (en) 2006-10-30 2010-12-10 Новартис АГ (CH) Heterocyclic compounds as antiinflammatory agents
DK2104535T3 (en) 2007-01-10 2011-04-04 Irm Llc Compounds and compositions as channel activating protease inhibitors
ES2361595T3 (en) 2007-05-07 2011-06-20 Novartis Ag organic compounds.
ES2654395T3 (en) 2007-12-10 2018-02-13 Novartis Ag Spirocyclic analogs amiloride as blocking ENaC
WO2009087224A1 (en) 2008-01-11 2009-07-16 Novartis Ag Pyrimidines as kinase inhibitors
ES2535736T3 (en) 2008-06-10 2015-05-14 Novartis Ag Pyrazine derivatives as blockers of epithelial sodium channels
JP2012516345A (en) 2009-01-29 2012-07-19 ノバルティス アーゲー Astrocytoma Therapeutic substituted benzimidazole
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
KR20120089643A (en) 2009-08-12 2012-08-13 노파르티스 아게 Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
JP5819831B2 (en) 2009-08-17 2015-11-24 インテリカイン, エルエルシー Heterocyclic compounds and their uses
KR20120089463A (en) 2009-08-20 2012-08-10 노파르티스 아게 Heterocyclic oxime compounds
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US9127000B2 (en) 2011-02-23 2015-09-08 Intellikine, LLC. Heterocyclic compounds and uses thereof
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Citations (6)

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Publication number Priority date Publication date Assignee Title
JPS4916872A (en) * 1972-04-21 1974-02-14
JPS4916870A (en) * 1972-06-14 1974-02-14
JPS4916871A (en) * 1972-06-14 1974-02-14
JPS5182258A (en) * 1974-04-25 1976-07-19 Yoshitomi Pharmaceutical Pirorijinonjudotaino seizoho
US4476311A (en) * 1980-03-12 1984-10-09 The Purdue Frederick Company Analgesic 4-carboxy-pyrrolidin-2-one compound
EP0350437A1 (en) * 1988-07-07 1990-01-10 Schering Aktiengesellschaft 3,4-Disubstituted phenyl-heterocycles and their use

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GB1350582A (en) * 1970-07-24 1974-04-18 Ucb Sa Cerivatives of 2-pyrrolidinone

Patent Citations (6)

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JPS4916872A (en) * 1972-04-21 1974-02-14
JPS4916870A (en) * 1972-06-14 1974-02-14
JPS4916871A (en) * 1972-06-14 1974-02-14
JPS5182258A (en) * 1974-04-25 1976-07-19 Yoshitomi Pharmaceutical Pirorijinonjudotaino seizoho
US4476311A (en) * 1980-03-12 1984-10-09 The Purdue Frederick Company Analgesic 4-carboxy-pyrrolidin-2-one compound
EP0350437A1 (en) * 1988-07-07 1990-01-10 Schering Aktiengesellschaft 3,4-Disubstituted phenyl-heterocycles and their use

Non-Patent Citations (6)

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Title
CHEMICAL ABSTRACTS, vol. 82, no. 19, 1974, Columbus, Ohio, US; abstract no. 125269 *
CHEMICAL ABSTRACTS, vol. 82, no. 21, 1974, Columbus, Ohio, US; abstract no. 139948 *
CHEMICAL ABSTRACTS, vol. 82, no. 21, 1974, Columbus, Ohio, US; abstract no. 139964 *
CHEMICAL ABSTRACTS, vol. 86, no. 11, 1977, Columbus, Ohio, US; abstract no. 72427 *
M. C. MARIVET ET. AL.: "Inhibition of Cyclic Adenosine-3',5'-monophosphate Phosphodiesterase from Vascular Smooth Muscle by Rolipram Analogues.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 32, 1989, WASHINGTON US, pages 1450 - 1457 *
See also references of WO9219594A1 *

Also Published As

Publication number Publication date Type
EP0584208A1 (en) 1994-03-02 application
CN1067244A (en) 1992-12-23 application
WO1992019594A1 (en) 1992-11-12 application
JPH06507405A (en) 1994-08-25 application
CA2102106A1 (en) 1992-11-03 application

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