EP0493526A4 - Stable therapeutic radionuclide compositions and methods for preparation thereof - Google Patents

Stable therapeutic radionuclide compositions and methods for preparation thereof

Info

Publication number
EP0493526A4
EP0493526A4 EP19900915689 EP90915689A EP0493526A4 EP 0493526 A4 EP0493526 A4 EP 0493526A4 EP 19900915689 EP19900915689 EP 19900915689 EP 90915689 A EP90915689 A EP 90915689A EP 0493526 A4 EP0493526 A4 EP 0493526A4
Authority
EP
European Patent Office
Prior art keywords
preparation
methods
therapeutic radionuclide
stable therapeutic
radionuclide compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900915689
Other versions
EP0493526A1 (en
Inventor
Jean-Luc Vanderheyden
Alan R. Fritzberg
Joseph E. Bugaj
Fu-Min Su
Prasanna Venkatesan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Poniard Pharmaceuticals Inc
Original Assignee
Poniard Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poniard Pharmaceuticals Inc filed Critical Poniard Pharmaceuticals Inc
Publication of EP0493526A1 publication Critical patent/EP0493526A1/en
Publication of EP0493526A4 publication Critical patent/EP0493526A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP19900915689 1989-09-22 1990-09-18 Stable therapeutic radionuclide compositions and methods for preparation thereof Withdrawn EP0493526A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41137289A 1989-09-22 1989-09-22
US411372 1989-09-22

Publications (2)

Publication Number Publication Date
EP0493526A1 EP0493526A1 (en) 1992-07-08
EP0493526A4 true EP0493526A4 (en) 1992-08-26

Family

ID=23628672

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900915689 Withdrawn EP0493526A4 (en) 1989-09-22 1990-09-18 Stable therapeutic radionuclide compositions and methods for preparation thereof

Country Status (4)

Country Link
EP (1) EP0493526A4 (en)
JP (1) JPH05502219A (en)
CA (1) CA2066779A1 (en)
WO (1) WO1991004057A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2541592A (en) * 1991-08-01 1993-03-02 Hybritech Incorporated Improvements in or relating to modified haptens useful as imaging and therapeutic agents
DE69518319T2 (en) * 1994-03-16 2000-12-14 Mallinckrodt Inc USE OF SURFACE-ACTIVE SUBSTANCES FOR THE STABILIZATION OF PEPTIDES AND PROTEINS FOR RADIOPHARMACEUTICAL USE
US5961955A (en) * 1997-06-03 1999-10-05 Coulter Pharmaceutical, Inc. Radioprotectant for peptides labeled with radioisotope
US20100056826A1 (en) * 2006-11-09 2010-03-04 Nihon Medi-Physicis Co., Ltd. Radioactive diagnostic imaging agent
EP3027228A4 (en) * 2013-08-01 2017-06-07 Rochester Institute of Technology Modular imaging agents containing amino acids and peptides

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2331550A1 (en) * 1972-06-22 1974-01-17 Radiochemical Centre Ltd SOLID PROTEIN PRODUCT CONTAINING FIBRINOGEN
FR2309215A1 (en) * 1975-04-30 1976-11-26 Hoffmann La Roche STABLE DIAGNOSTIC REAGENTS SUITABLE TO BE TRANSFORMED INTO RADIOMEDICINES
FR2527928A1 (en) * 1982-06-07 1983-12-09 Gansow Otto PROCESS FOR THE PREPARATION OF MONOCLONAL ANTIBODIES CONJUGATED WITH A METAL CHELATE AND SOLUTION CONTAINING THEM
EP0280209A2 (en) * 1987-02-20 1988-08-31 The Wistar Institute Monoclonal antibodies against melanoma-associated antigens, hybrid cell lines producing these antibodies, and use therefor
EP0284071A2 (en) * 1987-03-26 1988-09-28 Neorx Corporation Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy
EP0306168A1 (en) * 1987-08-12 1989-03-08 Immunomedics, Inc. Preparation of radiolabeled conjugates
EP0315188A2 (en) * 1987-11-06 1989-05-10 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions
US4880615A (en) * 1988-11-25 1989-11-14 Merck & Co., Inc. Stabilized radiopharmaceutical compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232000A (en) * 1978-06-28 1980-11-04 The Procter & Gamble Company Radioactive scanning agents with stabilizer
US4837003A (en) * 1984-09-13 1989-06-06 Mallinckrodt, Inc. Radiolabeled antibody fragments
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
GB8510726D0 (en) * 1985-04-26 1985-06-26 Amersham Int Plc Stabilised radio-labelled compounds
US4935222A (en) * 1986-06-13 1990-06-19 University Of Cincinnati Procedure for isolating and purifying radioactive ligated rhenium pharmaceuticals and use thereof and kit

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2331550A1 (en) * 1972-06-22 1974-01-17 Radiochemical Centre Ltd SOLID PROTEIN PRODUCT CONTAINING FIBRINOGEN
FR2309215A1 (en) * 1975-04-30 1976-11-26 Hoffmann La Roche STABLE DIAGNOSTIC REAGENTS SUITABLE TO BE TRANSFORMED INTO RADIOMEDICINES
FR2527928A1 (en) * 1982-06-07 1983-12-09 Gansow Otto PROCESS FOR THE PREPARATION OF MONOCLONAL ANTIBODIES CONJUGATED WITH A METAL CHELATE AND SOLUTION CONTAINING THEM
EP0280209A2 (en) * 1987-02-20 1988-08-31 The Wistar Institute Monoclonal antibodies against melanoma-associated antigens, hybrid cell lines producing these antibodies, and use therefor
EP0284071A2 (en) * 1987-03-26 1988-09-28 Neorx Corporation Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy
EP0306168A1 (en) * 1987-08-12 1989-03-08 Immunomedics, Inc. Preparation of radiolabeled conjugates
EP0315188A2 (en) * 1987-11-06 1989-05-10 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions
US4880615A (en) * 1988-11-25 1989-11-14 Merck & Co., Inc. Stabilized radiopharmaceutical compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9104057A1 *

Also Published As

Publication number Publication date
CA2066779A1 (en) 1991-03-23
EP0493526A1 (en) 1992-07-08
WO1991004057A1 (en) 1991-04-04
JPH05502219A (en) 1993-04-22

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19920320

AK Designated contracting states

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A4 Supplementary search report drawn up and despatched

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18D Application deemed to be withdrawn

Effective date: 19950831