EP0483152A4 - A method of reducing body weight and food intake using a dopamine d2 receptor agonist - Google Patents

A method of reducing body weight and food intake using a dopamine d2 receptor agonist

Info

Publication number
EP0483152A4
EP0483152A4 EP19900906612 EP90906612A EP0483152A4 EP 0483152 A4 EP0483152 A4 EP 0483152A4 EP 19900906612 EP19900906612 EP 19900906612 EP 90906612 A EP90906612 A EP 90906612A EP 0483152 A4 EP0483152 A4 EP 0483152A4
Authority
EP
European Patent Office
Prior art keywords
dopamine
body weight
receptor agonist
food intake
reducing body
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900906612
Other versions
EP0483152A1 (en
Inventor
James D. Belluzzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Whitby Research Inc
Original Assignee
Whitby Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitby Research Inc filed Critical Whitby Research Inc
Publication of EP0483152A1 publication Critical patent/EP0483152A1/en
Publication of EP0483152A4 publication Critical patent/EP0483152A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP19900906612 1989-05-09 1990-04-19 A method of reducing body weight and food intake using a dopamine d2 receptor agonist Withdrawn EP0483152A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34909189A 1989-05-09 1989-05-09
US349091 1989-05-09

Publications (2)

Publication Number Publication Date
EP0483152A1 EP0483152A1 (en) 1992-05-06
EP0483152A4 true EP0483152A4 (en) 1992-12-02

Family

ID=23370872

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900906612 Withdrawn EP0483152A4 (en) 1989-05-09 1990-04-19 A method of reducing body weight and food intake using a dopamine d2 receptor agonist

Country Status (3)

Country Link
EP (1) EP0483152A4 (en)
AU (1) AU5439890A (en)
WO (1) WO1990013294A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10041479A1 (en) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh New pharmaceutical composition for the administration of N-0923
DE10148233A1 (en) * 2001-09-28 2003-04-10 Boehringer Ingelheim Pharma Compounds to reduce excessive food intake
CA2483464C (en) 2002-05-17 2011-12-20 Duke University Method for treating obesity
MXPA05011557A (en) 2003-04-29 2006-03-09 Orexigen Therapeutics Inc Compositions for affecting weight loss.
BRPI0506829A (en) 2004-01-13 2007-05-29 Univ Duke Anticonvulsant and antipsychotic drug compositions and methods for their use to affect weight loss
CA2630624C (en) 2005-11-22 2013-08-06 Orexigen Therapeutics, Inc. Compositions and methods for increasing insulin sensitivity
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
KR20180066272A (en) 2006-11-09 2018-06-18 오렉시젠 세러퓨틱스 인크. Unit dosage packages
CA2725930A1 (en) 2008-05-30 2009-12-30 Orexigen Therapeutics, Inc. Methods for treating visceral fat conditions
BRPI0920645A2 (en) * 2008-10-13 2016-01-12 Interquim Sa process for the preparation of optically active (-) - 2- (n-propylamino_-5-methoxytetralma and - (-) - 2- (n-propylamino) -5-hydroxytetraline compounds
MX344303B (en) 2010-01-11 2016-12-13 Orexigen Therapeutics Inc Methods of providing weight loss therapy in patients with major depression.
IL300868A (en) 2012-06-06 2023-04-01 Orexigen Therapeutics Inc Methods of treating overweight and obesity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4189494A (en) * 1975-11-06 1980-02-19 Sandoz Ltd. Reducing free fatty acid of the blood and suppressing appetite
US4564628A (en) * 1983-01-03 1986-01-14 Nelson Research & Development Co. Substituted 2-aminotetralins

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 162, no. 1, 14th March 1989, pages 143-150, Elsevier Science Publishers B.V. (Biomedical Division); W. TIMMERMAN et al.: "Microdialysis and striatal dopamine release: stereoselective actions of the enantiomers of N-0437" *
PHYSIOLOGY & BEHAVIOR, vol. 44, nos. 4-5, 1988, pages 545-553, Pergamon Press plc, US; I.N. RUSK et al.: "Profile of the selective dopamine D-2 receptor agonist N-0437: its effects on palatability- and deprivation-induced feeding, and operant responding for food" *
See also references of WO9013294A1 *
SOC. NEUROSCI. ABSTR., vol. 12, 1986, page 1557, abstract no. 420.18; I. RUSK et al.: "Dopamine D1 and D2 receptors in relation to palatable food consumption in the rat" *
SOC. NEUROSCI. ABSTR., vol. 14, no. 1, 1988, page 614, abstract no. 249.6; I.N. RUSK et al.: "Microstructural analysis of feeding suppression and other behavioral changes induced by N-0437, a selective dopamine D2 agonist" *

Also Published As

Publication number Publication date
EP0483152A1 (en) 1992-05-06
AU5439890A (en) 1990-11-29
WO1990013294A1 (en) 1990-11-15

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Legal Events

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