EP0086775A4 - Heterocyclic amidino substituted ureas and their pharmaceutical uses. - Google Patents

Heterocyclic amidino substituted ureas and their pharmaceutical uses.

Info

Publication number
EP0086775A4
EP0086775A4 EP19810902423 EP81902423A EP0086775A4 EP 0086775 A4 EP0086775 A4 EP 0086775A4 EP 19810902423 EP19810902423 EP 19810902423 EP 81902423 A EP81902423 A EP 81902423A EP 0086775 A4 EP0086775 A4 EP 0086775A4
Authority
EP
European Patent Office
Prior art keywords
pharmaceutical uses
substituted ureas
amidino substituted
heterocyclic
heterocyclic amidino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19810902423
Other languages
German (de)
French (fr)
Other versions
EP0086775A1 (en
Inventor
William Lyon Studt
Harry Karl Zimmerman
Stuart Alan Dodson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rorer International Overseas Inc
Original Assignee
Rorer International Overseas Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rorer International Overseas Inc filed Critical Rorer International Overseas Inc
Publication of EP0086775A1 publication Critical patent/EP0086775A1/en
Publication of EP0086775A4 publication Critical patent/EP0086775A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
EP19810902423 1981-08-24 1981-08-24 Heterocyclic amidino substituted ureas and their pharmaceutical uses. Withdrawn EP0086775A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1981/001146 WO1983000627A1 (en) 1981-08-24 1981-08-24 Heterocyclic amidino substituted ureas and their pharmaceutical uses

Publications (2)

Publication Number Publication Date
EP0086775A1 EP0086775A1 (en) 1983-08-31
EP0086775A4 true EP0086775A4 (en) 1984-09-05

Family

ID=22161395

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19810902423 Withdrawn EP0086775A4 (en) 1981-08-24 1981-08-24 Heterocyclic amidino substituted ureas and their pharmaceutical uses.

Country Status (12)

Country Link
US (1) US4707478A (en)
EP (1) EP0086775A4 (en)
JP (1) JPS58501468A (en)
AU (1) AU543834B2 (en)
CA (1) CA1210394A (en)
CH (1) CH656125A5 (en)
DE (1) DE3152942T1 (en)
DK (1) DK181583D0 (en)
GB (1) GB2115419B (en)
NL (1) NL8120313A (en)
SE (1) SE452007B (en)
WO (1) WO1983000627A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3887800D1 (en) * 1987-08-04 1994-03-24 Ciba Geigy Substituted guanidines.
CA2116621C (en) * 1993-03-03 2001-07-24 Rene C. Gaudreault Novel anticancer agents
US5750547A (en) * 1995-01-06 1998-05-12 Universite Laval Certain carbanate anti-cancer agents
AUPN193095A0 (en) * 1995-03-24 1995-04-27 Polychip Pharmaceuticals Pty Ltd Potassium ion channel blockers
JP4206382B2 (en) * 2002-11-19 2009-01-07 アキリオン ファーマシューティカルズ，インコーポレーテッド Substituted arylthioureas and related compounds; inhibitors of viral replication
TW200600492A (en) * 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
CN114292225B (en) * 2022-01-10 2023-07-11 万华化学集团股份有限公司 Quaternary ammonium type strong-alkalinity anion exchange resin and method for preparing glycidyl methacrylate by catalysis thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE894172A (en) * 1981-08-24 1983-02-23 Rorer Internat Overseas Inc COMPOSITIONS FOR THE TREATMENT OF AMIDINO-UREA COCCIDIOSIS

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1194835A (en) * 1966-07-07 1970-06-10 Wellcome Found Novel 1-Amidino-3-Phenyl-Urea Derivatives, the preparation thereof and Compositions containing the same
US3798269A (en) * 1968-08-05 1974-03-19 R Cutler Amidinoureas and amidinothioureas
US3984467A (en) * 1969-03-03 1976-10-05 Sterling Drug Inc. Anthelmintic 1-(substituted phenyl)-3-alkanimidoyl ureas
US3933794A (en) * 1971-08-04 1976-01-20 The Upjohn Company 2-(2-Alkynylamino)-3H-1,4-benzodiazepines
US4220658A (en) * 1972-09-22 1980-09-02 William H. Rorer, Inc. Treatment of hypertension with amidinoureas
US4025652A (en) * 1975-03-31 1977-05-24 William H. Rorer, Inc. Amidinoureas
US4060635A (en) * 1975-03-31 1977-11-29 William H. Rorer, Inc. Amidinoureas for treating diarrhea
US4009163A (en) * 1973-08-24 1977-02-22 Sterling Drug Inc. Amidinoureas and amidinothioureas
US4163022A (en) * 1975-02-03 1979-07-31 Cooper Laboratories, Inc. Carbamylguanidine antimicrobial compounds
US4088785A (en) * 1976-03-25 1978-05-09 William H. Rorer, Inc. Amidinoureas for the treatment of cardinascular disorders
US4058557A (en) * 1976-03-30 1977-11-15 William H. Rorer, Inc. Amidinoureas
US4169155A (en) * 1976-03-30 1979-09-25 William H. Rorer, Inc. Method for treatment of gastrointestinal secretory and ulcerogenic disease conditions or symptoms in mammals
US4178387A (en) * 1976-03-30 1979-12-11 William H. Rorer, Inc. Method for the treatment of arrhythmia
JPS53108970A (en) * 1977-03-07 1978-09-22 Yamanouchi Pharmaceut Co Ltd Novel guanidine derivative and its preparation
US4166860A (en) * 1977-10-11 1979-09-04 William H. Rorer, Inc. Imidazole amidinoureas for stimulating H2 -receptors
US4304786A (en) * 1978-09-14 1981-12-08 William H. Rorer, Inc. Amidinoureas
US4225315A (en) * 1978-11-13 1980-09-30 William H. Rorer, Inc. Triazinones from amidinoureas
DE2853220A1 (en) * 1978-12-09 1980-07-03 Hoechst Ag NEW AMINO-PYRIMIDINE CARBANILIDES, METHOD FOR THE PRODUCTION THEREOF, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS, AND THEIR USE
US4241087A (en) * 1979-04-02 1980-12-23 William H. Rorer, Inc. Dysmenorrhea treatment
US4340609A (en) * 1980-01-02 1982-07-20 William H. Rorer, Inc. Amidinourea derivative veterinary compositions for suppression of parasitemia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE894172A (en) * 1981-08-24 1983-02-23 Rorer Internat Overseas Inc COMPOSITIONS FOR THE TREATMENT OF AMIDINO-UREA COCCIDIOSIS

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARZNEIMITTEL FORSCHUNG/DRUG RESEARCH, vol. 28, no. 8a, August 1978, Verlag Publisher *
CHEMICAL ABSTRACTS, vol. 90, no. 11, March 12, 1979, page 608, abstract no. 87289f COLUMBUS OHIO (US) & JP - A - 78 108 970 (YAMANOUCHI PHARMACEUTICAL CO., LTD.) (22-09-1978) *

Also Published As

Publication number Publication date
GB2115419A (en) 1983-09-07
SE8302283D0 (en) 1983-04-22
DK181583A (en) 1983-04-25
JPS58501468A (en) 1983-09-01
WO1983000627A1 (en) 1983-03-03
GB8310965D0 (en) 1983-05-25
SE452007B (en) 1987-11-09
DK181583D0 (en) 1983-04-25
AU543834B2 (en) 1985-05-02
GB2115419B (en) 1985-10-02
NL8120313A (en) 1983-07-01
EP0086775A1 (en) 1983-08-31
AU7539481A (en) 1983-03-08
US4707478A (en) 1987-11-17
CH656125A5 (en) 1986-06-13
DE3152942T1 (en) 1983-12-15
SE8302283L (en) 1983-04-22
CA1210394A (en) 1986-08-26

Similar Documents

Publication Publication Date Title
DE3166093D1 (en) N-substituted pseudo-aminosugars, their production and use
PH25637A (en) Dipyridamole-containing pharmaceutical form
MY8700843A (en) N-phenylsulfonyl-n-primidinyl and-triazinyl ureas
PH22014A (en) Heterocyclic derivatives and pharmaceutical compositions containing the same
DE3580304D1 (en) DRUG.
DE3262455D1 (en) Diphenoxypropane derivatives, their production and use
PH22022A (en) Pyrimidine derivatives, pharmaceutical composition containing same and use thereof
GB2101590B (en) Carboximide derivatives and pharmaceuticals thereof.
AU555880B2 (en) N-substituted 1,2,4 triosoles and imidazoles
GB2125401B (en) Desoxyuridine derivatives and their use as pharmaceuticals
IL65285A (en) 2-substituted-4,5-diarylthiazoles,their manufacture and pharmaceutical compositions containing them
PH16982A (en) Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide and its pharmaceutical composition
ZA855072B (en) Heterocyclic pharmaceutical compounds,preparation and use
DE3268615D1 (en) Guanidine derivatives
EP0086775A4 (en) Heterocyclic amidino substituted ureas and their pharmaceutical uses.
GB2098983B (en) Amidine derivatives
OA08136A (en) Heterocyclic herbicides.
DE3260505D1 (en) Alicyclic compounds, their production and use
PH21920A (en) Hydantoin derivatives and medicine containing the same
EP0084053A4 (en) Pharmaceutical composition and the use of Sn- or Cr-protoporphyrin for the manufacture thereof.
GB8525673D0 (en) Pharmaceutical agent
EP0079392A4 (en) Composite oxyalkoxides and derivatives thereof.
EP0078839A4 (en) Heterocyclic amidinoureas.
DE3266355D1 (en) Octahydrotetracyanoquinodimethane and derivatives thereof
EP0172233A4 (en) Punaglandins and pharmaceutical use thereof.

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): FR

17P Request for examination filed

Effective date: 19830816

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19880104

RIN1 Information on inventor provided before grant (corrected)

Inventor name: STUDT, WILLIAM LYON

Inventor name: ZIMMERMAN, HARRY KARL

Inventor name: DODSON, STUART, ALAN