EP0000506A3 - Substituted phenyl o- or s- etherified cycloalkanols, a process for their preparation and their application as hypolipidemia, their esters with cyclopropanecarboxylic acids and the application of these esters as insecticides - Google Patents

Substituted phenyl o- or s- etherified cycloalkanols, a process for their preparation and their application as hypolipidemia, their esters with cyclopropanecarboxylic acids and the application of these esters as insecticides Download PDF

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Publication number
EP0000506A3
EP0000506A3 EP78100374A EP78100374A EP0000506A3 EP 0000506 A3 EP0000506 A3 EP 0000506A3 EP 78100374 A EP78100374 A EP 78100374A EP 78100374 A EP78100374 A EP 78100374A EP 0000506 A3 EP0000506 A3 EP 0000506A3
Authority
EP
European Patent Office
Prior art keywords
esters
application
preparation
cycloalkanols
etherified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP78100374A
Other languages
German (de)
French (fr)
Other versions
EP0000506A2 (en
Inventor
Saleem Dr. Farooq
Friedrich Dr. Karrer
Georges Dr. Haas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of EP0000506A2 publication Critical patent/EP0000506A2/en
Publication of EP0000506A3 publication Critical patent/EP0000506A3/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups

Abstract

Verätherte Cycloalkanole der Formel worin X₁ Sauerstoff, Schwefel oder Methylen, X₂ Sauerstoff oder Schwefel, A einen gegebenenfalls substituierten Phenylrest und n eine ganze Zahl von 1 bis und mit 10 darstellen sowie Verfahren zu deren Herstellung. Etherified cycloalkanols of the formula wherein X₁ is oxygen, sulfur or methylene, X₂ is oxygen or sulfur, A is an optionally substituted phenyl radical and n is an integer from 1 to 10 and methods for their preparation.

Diese Verbindungen, insbesondere das 2-(4-Phenoxy-phenoxy)-cyclopentan-1-ol, besitzen eine Lipidsenkende Wirksamkeit. These compounds, especially 2- (4-phenoxy-phenoxy) -cyclopentan-1-ol, have a lipid-lowering end Effectiveness.

Ferner sind sie Zwischenprodukte zur Herstellung der insektiziden Cyclopropansäureester der Formel worin A, X₁, X₂, und n die oben gegebene Bedeutung besitzen und R¹, R², R³ und R⁴ je Wasserstoff, Methyl oder Chlor bedeuten. They are also intermediates for the preparation of the insecticidal cyclopropanoic acid esters of the formula wherein A, X₁, X₂, and n have the meaning given above and R¹, R², R³ and R⁴ each represent hydrogen, methyl or chlorine.

EP78100374A 1977-07-20 1978-07-12 Substituted phenyl o- or s- etherified cycloalkanols, a process for their preparation and their application as hypolipidemia, their esters with cyclopropanecarboxylic acids and the application of these esters as insecticides Withdrawn EP0000506A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH9002/77 1977-07-20
CH900277 1977-07-20

Publications (2)

Publication Number Publication Date
EP0000506A2 EP0000506A2 (en) 1979-02-07
EP0000506A3 true EP0000506A3 (en) 1979-06-27

Family

ID=4347259

Family Applications (1)

Application Number Title Priority Date Filing Date
EP78100374A Withdrawn EP0000506A3 (en) 1977-07-20 1978-07-12 Substituted phenyl o- or s- etherified cycloalkanols, a process for their preparation and their application as hypolipidemia, their esters with cyclopropanecarboxylic acids and the application of these esters as insecticides

Country Status (11)

Country Link
US (1) US4175137A (en)
EP (1) EP0000506A3 (en)
JP (1) JPS5422343A (en)
DD (1) DD138202A5 (en)
DK (1) DK322678A (en)
ES (2) ES471829A1 (en)
FI (1) FI782253A (en)
IL (1) IL55163A0 (en)
IT (1) IT7850347A0 (en)
NO (1) NO782492L (en)
ZA (1) ZA784104B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002214B1 (en) * 1977-12-01 1981-05-13 Bayer Ag Benzyl ethers of cyclic 1,2-diols, methods for their preparation and their use as herbicides
DE2951939A1 (en) * 1979-12-22 1981-07-16 Degussa Ag, 6000 Frankfurt CYCLOPROPANCARBONIC ACID ESTER, METHOD FOR THE PRODUCTION AND USE THEREOF
US4459305A (en) * 1980-04-10 1984-07-10 Dainippon Sochugiku Kabushiki Kaisha Cyclopropanecarboxylic acid ester derivatives, a method of manufacturing them, and their uses
JPS5958067A (en) * 1982-09-28 1984-04-03 Nippon Steel Corp Writing material
DE3812967A1 (en) * 1987-06-24 1989-01-05 Bayer Ag AZOLYL METHYL CYCLOPROPYL DERIVATIVES

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH372293A (en) * 1957-03-01 1963-10-15 Bayer Ag Process for the production of thiomethylalen
NL7504534A (en) * 1974-04-18 1975-10-21 Ciba Geigy PROCEDURE FOR PREPARING PHENOXY-PHENYL ETHERS AND PROCEDURE FOR APPLYING THEM IN CONTROL OF HARMFUL ORGANISMS.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3098105A (en) * 1962-06-27 1963-07-16 Dow Chemical Co Alkanol phenoxy thioethers
US3272854A (en) * 1963-07-18 1966-09-13 Us Rubber Co Cycloaliphatic sulfite esters
US3379752A (en) * 1964-05-20 1968-04-23 Merck & Co Inc Phenoxy substituted 3-hydroxyalkanoic acids and a method for their preparation
US3506682A (en) * 1966-08-25 1970-04-14 Syntex Corp Phenylcyclopropyl carbinols and process for their preparation
US3715401A (en) * 1970-05-01 1973-02-06 Gen Electric Process for producing 3-hydroxyalkyl ethers
US3962459A (en) * 1973-09-04 1976-06-08 Sandoz, Inc. Lipidemia treatment with p-phenoxy-alkylphenone compositions
US4051173A (en) * 1974-04-02 1977-09-27 Merck Patent Gesellschaft Mit Beschrankter Haftung Phenoxyalkanol derivatives
NL7504667A (en) * 1974-04-26 1975-10-28 Ciba Geigy PROCEDURE FOR PREPARING NEW ETHERS.
US4065503A (en) * 1974-09-30 1977-12-27 Sandoz, Inc. P-Phenoxy-alkylphenones and corresponding alcohols
US4017549A (en) * 1974-10-24 1977-04-12 Ciba-Geigy Corporation Diphenylmethane ether derivatives
DK451175A (en) * 1974-10-24 1976-04-25 Ciba Geigy Ag PEST CONTROL
US4080474A (en) * 1975-02-19 1978-03-21 Beecham Group Limited Hypolipidaemic compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH372293A (en) * 1957-03-01 1963-10-15 Bayer Ag Process for the production of thiomethylalen
NL7504534A (en) * 1974-04-18 1975-10-21 Ciba Geigy PROCEDURE FOR PREPARING PHENOXY-PHENYL ETHERS AND PROCEDURE FOR APPLYING THEM IN CONTROL OF HARMFUL ORGANISMS.

Also Published As

Publication number Publication date
JPS5422343A (en) 1979-02-20
DK322678A (en) 1979-01-21
US4175137A (en) 1979-11-20
ES478880A1 (en) 1979-07-01
DD138202A5 (en) 1979-10-17
FI782253A (en) 1979-01-21
IT7850347A0 (en) 1978-07-18
ZA784104B (en) 1979-07-25
NO782492L (en) 1979-01-23
IL55163A0 (en) 1978-09-29
ES471829A1 (en) 1979-10-01
EP0000506A2 (en) 1979-02-07

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: HAAS, GEORGES, DR.

Inventor name: KARRER, FRIEDRICH, DR.

Inventor name: FAROOQ, SALEEM, DR.