EG19944A - Process for preparing of quinuclidine derivatives - Google Patents

Process for preparing of quinuclidine derivatives

Info

Publication number
EG19944A
EG19944A EG28492A EG28492A EG19944A EG 19944 A EG19944 A EG 19944A EG 28492 A EG28492 A EG 28492A EG 28492 A EG28492 A EG 28492A EG 19944 A EG19944 A EG 19944A
Authority
EG
Egypt
Prior art keywords
preparing
quinuclidine derivatives
quinuclidine
derivatives
Prior art date
Application number
EG28492A
Other languages
English (en)
Inventor
Hiroshi Kondo
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24845673&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EG19944(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of EG19944A publication Critical patent/EG19944A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EG28492A 1991-05-31 1992-05-30 Process for preparing of quinuclidine derivatives EG19944A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70840491A 1991-05-31 1991-05-31

Publications (1)

Publication Number Publication Date
EG19944A true EG19944A (en) 1997-02-27

Family

ID=24845673

Family Applications (1)

Application Number Title Priority Date Filing Date
EG28492A EG19944A (en) 1991-05-31 1992-05-30 Process for preparing of quinuclidine derivatives

Country Status (41)

Country Link
US (3) US5807867A (pt)
EP (1) EP0587723B1 (pt)
JP (2) JPH0733386B2 (pt)
KR (1) KR100214905B1 (pt)
CN (1) CN1048492C (pt)
AP (1) AP299A (pt)
AT (1) ATE135006T1 (pt)
AU (1) AU657552B2 (pt)
BG (1) BG61694B1 (pt)
BR (1) BR9206073A (pt)
CA (1) CA2102179C (pt)
CZ (1) CZ281403B6 (pt)
DE (4) DE122006000066I1 (pt)
DK (1) DK0587723T3 (pt)
EG (1) EG19944A (pt)
ES (1) ES2084361T3 (pt)
FI (1) FI114475B (pt)
GR (1) GR3019687T3 (pt)
GT (1) GT199200028A (pt)
HU (1) HU217548B (pt)
IE (1) IE72473B1 (pt)
IL (1) IL102008A (pt)
IS (1) IS1611B (pt)
LU (1) LU91293I2 (pt)
MA (1) MA22539A1 (pt)
MX (1) MX9202554A (pt)
NL (1) NL300250I2 (pt)
NO (2) NO302701B1 (pt)
NZ (2) NZ242956A (pt)
OA (1) OA09867A (pt)
PL (1) PL171379B1 (pt)
PT (1) PT100546B (pt)
RO (1) RO110499B1 (pt)
RU (1) RU2103269C1 (pt)
SK (1) SK278788B6 (pt)
TW (1) TW204349B (pt)
UA (1) UA27776C2 (pt)
UY (1) UY23422A1 (pt)
WO (1) WO1992021677A1 (pt)
YU (1) YU48995B (pt)
ZA (1) ZA923942B (pt)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100214905B1 (ko) * 1991-05-31 1999-08-02 디. 제이. 우드, 스피겔 알렌 제이 퀴누클리딘 유도체
EP0589924B1 (en) * 1991-06-20 1996-09-04 Pfizer Inc. Fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles
ES2164072T3 (es) * 1992-08-19 2002-02-16 Pfizer Heterociclos no aromaticos que contienen nitrogeno sustituidos con bencilamino.
DE69307340T2 (de) * 1992-11-12 1997-04-24 Pfizer Chinuclidin derivat als substanz p antagonist
US5344830A (en) * 1992-12-10 1994-09-06 Merck & Co., Inc. N,N-diacylpiperazine tachykinin antagonists
IL109646A0 (en) * 1993-05-19 1994-08-26 Pfizer Heteroatom substituted alkyl benzylamino-quinuclidines
JP2822274B2 (ja) * 1993-05-19 1998-11-11 ファイザー製薬株式会社 P物質拮抗剤としてのヘテロ原子置換アルキルベンジルアミノキヌクリジン類
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
EP0653208A3 (en) * 1993-11-17 1995-10-11 Pfizer Substance P antagonists for the treatment or prevention of sunburn.
EP0659409A3 (en) * 1993-11-23 1995-08-09 Pfizer Substance P antagonists for the inhibition of angiogenesis.
EP0655246A1 (en) * 1993-11-30 1995-05-31 Pfizer Inc. Substance P antagonists for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria
IL116249A (en) * 1994-12-12 2003-07-06 Pfizer Nk-1 receptor antagonists for the treatment of neuronal damage and stroke
PE8798A1 (es) * 1995-07-17 1998-03-02 Pfizer Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil]
TW458774B (en) 1995-10-20 2001-10-11 Pfizer Antiemetic pharmaceutical compositions
IL123740A0 (en) * 1997-03-28 1998-10-30 Pfizer NK-1 receptor antagonists for the treatment of delayed emesis
NZ329807A (en) * 1997-04-23 2000-07-28 Pfizer NK-1 receptor antagonists and P receptor antagonists 2-Diarylmethyl-3-amino-1-azabicyclo[2.2.2]octane derivatives and amino substituted N-containing rings as agents for treating irritable bowel syndrome
CA2321155A1 (en) * 1998-03-19 1999-09-23 Takayuki Doi Heterocyclic compounds, their production and use as tachykinin receptor antagonists
US6387925B1 (en) * 1999-06-01 2002-05-14 Pfizer Inc. Polymorphs of a crystalline azo-bicyclo (2.2.2) oct-3-yl amine citrate and their pharmaceutical compositions
US6255320B1 (en) * 1999-06-01 2001-07-03 Pfizer Inc. Polymorphs of a crystalline azo-bicyclo (2,2,2) octan-3-amine citrate and their pharmaceutical compositions
US6262067B1 (en) * 1999-06-22 2001-07-17 Pfizer Inc. Polymorphs of a crystalline azo-bicyclo 2,2,2 OCT-3-yl amine dihydrochloride and their pharmaceutical compositions
CA2324116A1 (en) * 1999-10-25 2001-04-25 Susan Beth Sobolov-Jaynes Nk-1 receptor antagonists and eletriptan for the treatment of migraine
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
CA2389306C (en) 1999-11-03 2010-03-30 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
IL142810A0 (en) * 2000-05-03 2002-03-10 Pfizer Prod Inc Pharmaceutical uses for fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles
EP1299393A2 (en) 2000-07-11 2003-04-09 Bristol-Myers Squibb Pharma Company 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
US20020049211A1 (en) * 2000-09-06 2002-04-25 Sobolov-Jaynes Susan Beth Combination treatment for depression and anxiety
EP1192952A3 (en) * 2000-09-28 2003-03-26 Pfizer Products Inc. Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist
HUP0401154A2 (hu) * 2001-07-20 2004-10-28 Pfizer Products Inc. NK-1 receptor antagonisták használata kutyák, macskák és lovak nemkívánatos viselkedésének módosítására
US6686507B2 (en) 2002-03-06 2004-02-03 Pfizer Inc Purification of 2-methoxy-5-trifluoromethoxybenzaldehyde
US6861526B2 (en) * 2002-10-16 2005-03-01 Pfizer Inc. Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine
WO2005045395A2 (en) * 2003-10-27 2005-05-19 Meyer Donald W Method of detecting bovine spongiform encephalopathy
JP4864719B2 (ja) * 2003-11-26 2012-02-01 ファイザー・プロダクツ・インク Gsk−3インヒビターとしてのアミノピラゾール誘導体
AU2005216709B2 (en) * 2004-01-30 2008-02-07 Zoetis Services Llc Antimicrobial preservatives to achieve multi-dose formulation using beta-cyclodextrins for liquid dosage forms
RU2337685C2 (ru) * 2004-01-30 2008-11-10 Пфайзер Продактс Инк. Антагонисты нейрокининового рецептора nk-1 для выхода из наркоза
KR100812046B1 (ko) * 2004-02-02 2008-03-10 화이자 프로덕츠 인크. 1-(2s,3s)-2-벤즈히드릴-n-(5-삼급-부틸-2-메톡시벤질)퀴누클리딘-3-아민의 제조 방법
US7541357B2 (en) 2004-07-15 2009-06-02 Amr Technology, Inc. Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US8362075B2 (en) 2005-05-17 2013-01-29 Merck Sharp & Dohme Corp. Cyclohexyl sulphones for treatment of cancer
WO2007011820A2 (en) 2005-07-15 2007-01-25 Amr Technology, Inc. Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
KR20080048502A (ko) 2005-09-29 2008-06-02 머크 앤드 캄파니 인코포레이티드 멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
EP2083831B1 (en) 2006-09-22 2013-12-25 Merck Sharp & Dohme Corp. Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
CN101190330A (zh) 2006-11-30 2008-06-04 深圳市鼎兴生物医药技术开发有限公司 胆碱酯酶在拮抗速激肽药物中的应用
JP4611444B2 (ja) 2007-01-10 2011-01-12 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー ポリ(adp−リボース)ポリメラーゼ(parp)阻害剤としてのアミド置換インダゾール
EP2117538A1 (en) 2007-01-24 2009-11-18 Glaxo Group Limited Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
EP2145884B1 (en) 2007-04-02 2014-08-06 Msd K.K. Indoledione derivative
JP5501227B2 (ja) 2007-06-27 2014-05-21 メルク・シャープ・アンド・ドーム・コーポレーション ヒストンデアセチラーゼ阻害剤としての4−カルボキシベンジルアミノ誘導体
JP2011515343A (ja) 2008-03-03 2011-05-19 タイガー ファーマテック チロシンキナーゼ阻害薬
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
EP2413932A4 (en) 2009-04-01 2012-09-19 Merck Sharp & Dohme INHIBITORS OF AKT ACTIVITY
KR20120034644A (ko) 2009-05-12 2012-04-12 알바니 몰레큘라 리써치, 인크. 아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도
MX2011011907A (es) 2009-05-12 2012-01-20 Albany Molecular Res Inc 7-([1,2,4,]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2, 3,4-tetrahidroisoquinolina y uso de la misma.
CN102638982B (zh) 2009-05-12 2015-07-08 百时美施贵宝公司 (S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途
EP2488028B1 (en) 2009-10-14 2020-08-19 Merck Sharp & Dohme Corp. Substituted piperidines that increase p53 activity and the uses thereof
WO2011163330A1 (en) 2010-06-24 2011-12-29 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
AU2011285909B2 (en) 2010-08-02 2016-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
EP2606134B1 (en) 2010-08-17 2019-04-10 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
WO2012027236A1 (en) 2010-08-23 2012-03-01 Schering Corporation NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
US8946216B2 (en) 2010-09-01 2015-02-03 Merck Sharp & Dohme Corp. Indazole derivatives useful as ERK inhibitors
EP2615916B1 (en) 2010-09-16 2017-01-04 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel erk inhibitors
EP3766975A1 (en) 2010-10-29 2021-01-20 Sirna Therapeutics, Inc. Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
EP2654748B1 (en) 2010-12-21 2016-07-27 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
CN103732592A (zh) 2011-04-21 2014-04-16 默沙东公司 胰岛素样生长因子-1受体抑制剂
US9782397B2 (en) 2011-07-04 2017-10-10 Irbm Science Park S.P.A. Treatment of corneal neovascularization
US9023865B2 (en) 2011-10-27 2015-05-05 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
EP3919620A1 (en) 2012-05-02 2021-12-08 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
MX2015004041A (es) 2012-09-28 2015-07-06 Merck Sharp & Dohme Compuestos novedosos que son inhibidores de erk.
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
SI2925888T1 (en) 2012-11-28 2018-02-28 Merck Sharp & Dohme Corp. Compounds and methods for the treatment of cancer
CA2895504A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
EP3041938A1 (en) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Circular polynucleotides
EP3525785A4 (en) 2016-10-12 2020-03-25 Merck Sharp & Dohme Corp. KDM5 INHIBITORS
US11160809B2 (en) 2017-04-10 2021-11-02 Chase Therapeutics Corporation NK1-antagonist combination and method for treating synucleinopathies
CN106977512B (zh) * 2017-05-04 2019-01-01 海门慧聚药业有限公司 制备马罗匹坦游离碱的方法
BR112019028034A2 (pt) 2017-06-30 2020-07-07 Chase Therapeutics Corporation composições de antagonista de nk-1 e métodos para uso no tratamento da depressão
US10947234B2 (en) 2017-11-08 2021-03-16 Merck Sharp & Dohme Corp. PRMT5 inhibitors
EP3758688B1 (en) 2018-02-26 2024-03-27 Ospedale San Raffaele S.r.l. Nk-1 antagonists for use in the treatment of ocular pain
KR102102109B1 (ko) * 2018-07-10 2020-04-20 성균관대학교산학협력단 N-벤즈히드릴 퀴뉴클리딘 유도체를 포함하는 나트륨 누출 채널 억제용 조성물
EP3833668A4 (en) 2018-08-07 2022-05-11 Merck Sharp & Dohme Corp. PRMT5 INHIBITORS
US11981701B2 (en) 2018-08-07 2024-05-14 Merck Sharp & Dohme Llc PRMT5 inhibitors
US20230134843A1 (en) 2020-03-11 2023-05-04 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005525A1 (en) * 1988-11-23 1990-05-31 Pfizer Inc. Quinuclidine derivatives as substance p antagonists
DE69105131T2 (de) * 1990-06-01 1995-03-23 Pfizer 3-amino-2-arylchinuclidine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
DE4026743A1 (de) * 1990-08-24 1992-02-27 Teves Gmbh Alfred Blockiergeschuetzte bremsanlage fuer kraftfahrzeuge
US5716965A (en) * 1991-05-22 1998-02-10 Pfizer Inc. Substituted 3-aminoquinuclidines
KR100214905B1 (ko) * 1991-05-31 1999-08-02 디. 제이. 우드, 스피겔 알렌 제이 퀴누클리딘 유도체
ES2149767T5 (es) * 1991-09-20 2005-06-16 Glaxo Group Limited Nuevo uso medico para antagonistas de taquiquininas.
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
US5340826A (en) * 1993-02-04 1994-08-23 Pfizer Inc. Pharmaceutical agents for treatment of urinary incontinence
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
EP0655246A1 (en) * 1993-11-30 1995-05-31 Pfizer Inc. Substance P antagonists for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria
US5576317A (en) * 1994-12-09 1996-11-19 Pfizer Inc. NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis
US5990125A (en) * 1996-01-19 1999-11-23 Pfizer Inc. NK-1 receptor antagonists for the treatment of cancer
EP0785198B1 (de) * 1996-01-19 2000-07-05 Lonza Ag Verfahren zur Herstellung von optisch aktivem 3-Chinuclidinol

Also Published As

Publication number Publication date
SK390692A3 (en) 1998-02-04
DE69208877D1 (de) 1996-04-11
NO934312D0 (no) 1993-11-29
WO1992021677A1 (en) 1992-12-10
DE122006000066I1 (de) 2007-03-22
IL102008A (en) 1995-12-08
IS3871A (is) 1992-12-02
DE9290063U1 (de) 1994-02-24
RO110499B1 (ro) 1996-01-30
CA2102179A1 (en) 1992-12-01
NO302701B1 (no) 1998-04-14
UA27776C2 (uk) 2000-10-16
EP0587723B1 (en) 1996-03-06
BR9206073A (pt) 1994-12-06
FI935297A (fi) 1993-11-29
HUT70151A (en) 1995-09-28
MA22539A1 (fr) 1992-12-31
UY23422A1 (es) 1992-11-12
MX9202554A (es) 1992-11-01
NZ242956A (en) 1995-06-27
CZ390692A3 (en) 1994-02-16
ES2084361T3 (es) 1996-05-01
IS1611B (is) 1996-10-18
CZ281403B6 (cs) 1996-09-11
TW204349B (pt) 1993-04-21
CN1048492C (zh) 2000-01-19
DE122006000066I2 (de) 2007-12-06
AP299A (en) 1994-01-14
CN1067428A (zh) 1992-12-30
NL300250I2 (nl) 2007-03-01
IL102008A0 (en) 1992-12-30
PT100546B (pt) 1999-12-31
US5807867A (en) 1998-09-15
US5939433A (en) 1999-08-17
BG98248A (bg) 1994-07-29
ZA923942B (en) 1993-11-29
CA2102179C (en) 1998-10-27
RU2103269C1 (ru) 1998-01-27
YU48995B (sh) 2003-04-30
ATE135006T1 (de) 1996-03-15
NZ270673A (en) 1997-07-27
US6222038B1 (en) 2001-04-24
IE72473B1 (en) 1997-04-23
GT199200028A (es) 1993-11-20
FI114475B (fi) 2004-10-29
NO2007003I2 (no) 2011-04-18
NL300250I1 (nl) 2007-02-01
DE69208877T2 (de) 1996-07-25
HU9303393D0 (en) 1994-03-28
BG61694B1 (bg) 1998-03-31
JPH07285965A (ja) 1995-10-31
DK0587723T3 (da) 1996-04-01
JPH0733386B2 (ja) 1995-04-12
NO2007003I1 (no) 2007-03-26
KR100214905B1 (ko) 1999-08-02
AU657552B2 (en) 1995-03-16
JPH06504292A (ja) 1994-05-19
LU91293I2 (fr) 2007-02-06
OA09867A (en) 1994-08-15
IE921729A1 (en) 1992-12-02
AP9200384A0 (en) 1992-07-31
PL171379B1 (en) 1997-04-30
JP2645225B2 (ja) 1997-08-25
AU1990192A (en) 1993-01-08
YU56492A (sh) 1995-03-27
EP0587723A1 (en) 1994-03-23
GR3019687T3 (en) 1996-07-31
NO934312L (no) 1993-11-29
FI935297A0 (fi) 1993-11-29
SK278788B6 (sk) 1998-02-04
HU217548B (hu) 2000-02-28
PT100546A (pt) 1993-08-31

Similar Documents

Publication Publication Date Title
EG19944A (en) Process for preparing of quinuclidine derivatives
EG19976A (en) Process for preparing of stereoselective preparation of substituted piperidines
YU20288A (en) Process for preparing derivatives of adenosyn 5-carboxamides
HUT62903A (en) Process for producing cefalosporin derivatives
YU125389A (en) Process for preparing derivatives of tricyclical 3-oxo-propan-nitryl
EP0507124A3 (en) Process for preparing cephem derivatives
GR910100427A (en) Process for preparing 8-chloroquinolone derivatives
EP0457730A3 (en) Process for preparation of thioderivatives of alkylhydroxyanilinotriazine
EP0444708A3 (en) Process for preparation of beta-lactam derivatives
YU200888A (en) Process for preparing substituted azacyclohexylic derivatives
HUT62860A (en) Process for producing 5-substituted-2-chloropyridine derivatives
EP0503603A3 (en) Process for preparing 2-exo-methylene-penam derivatives
GB2275927B (en) Process for the preparation of cephem derivatives
GB8817052D0 (en) Process for preparing n15-alkyl derivatives of teicoplanin compounds
HUT67269A (en) Process for preparing benzofuranyl-imidazole derivatives
HUT57218A (en) Process for producing cephalosporin derivatives
CS35592A3 (en) Process for preparing ergoline derivatives
GB9205920D0 (en) Process for the preparation of pyrethroide derivatives
CS164791A3 (en) Process for preparing ergoline derivatives
HUT65659A (en) Process for preparing 9-nitro-7-(substituted)-6-demethyl-6-desoxytetracyclin derivatives
GB9111260D0 (en) Process for the preparation of 4-amino-unsaturated androstanedione derivatives
HU901388D0 (en) Process for preparation of new cephalosporin derivatives
IL84950A0 (en) Process for preparing alkoxyalkyli-denehydrazinopyridazine derivatives
YU39688A (en) Process for preparing derivatives of indolopyrazine
YU8588A (en) Process for preparing derivative of 10-dihydro-10-deoxo-11-azaerithronolide